3,137 results on '"Keller, K"'
Search Results
2. A field test of compact active transponders for InSAR geodesy
- Author
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Meister A., Balasis-Levinsen J., Keller K., Pedersen M. R. V., Merryman Boncori J. P., and Jensen M.
- Subjects
artificial radar reflector ,cat ,compact active transponder ,ecr ,electronic corner reflector ,field test ,insar ,insar geodesy ,interferometric synthetic aperture radar ,sentinel-1 ,Geodesy ,QB275-343 - Abstract
Compact active transponders (CATs) – also termed electronic corner reflectors – are compact electronic devices designed to receive, actively amplify and re-transmit a radar signal, e.g. a C-band radar signal received from a Sentinel-1 satellite. CATs can potentially be useful for a number of purposes, e.g. if co-located with geodetic infrastructure. However, CATs have only recently become commercially available, and therefore, the usability and long-term performance of CATs are not well known. In this study, two CATs are tested under realistic operating conditions for a period of 14 months, from July 2020 to September 2021. The displacement time series of the CATs are determined from a persistent scatterers interferometric synthetic aperture radar processing of four tracks of Sentinel-1A/-1B data with a passive corner reflector (CR) as the spatial reference. The displacement time series of the CATs are evaluated against a ground truth established from repeated levellings between the CR and the CATs. Based on the results of this study, it is found that a sudden vertical displacement of a CAT can be determined with an accuracy better than 1 cm, possibly a few millimetres. Furthermore, it is found that the mean vertical velocity of a CAT, calculated from 14 months of interferometric synthetic aperture radar displacement time series, can be determined with an accuracy of a few mm/year. Finally, the line of sight (LoS) phase error is generally found to be moderately correlated with temperature, with an instrument-specific linear relationship between LoS error and temperature ranging between approx. 0.1 and 0.2 mm/°C. This correlation between LoS phase error and temperature can in principle be used for instrument-specific calibrations, which is a topic that should be addressed in future studies.
- Published
- 2024
- Full Text
- View/download PDF
3. POS0628 EROSIVE PROGRESSION ASSESSED BY HIGH-RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY COMPARED TO CONVENTIONAL RADIOGRAPHY: A ONE-YEAR COHORT STUDY IN 310 PATIENTS WITH ESTABLISHED RHEUMATOID ARTHRITIS
- Author
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Therkildsen, J., primary, Klose-Jensen, R., additional, Hänel, M., additional, Langdahl, B., additional, Thygesen, J., additional, Thomsen, J. S., additional, Manske, S. L., additional, Keller, K., additional, and Hauge, E. M., additional
- Published
- 2024
- Full Text
- View/download PDF
4. POS0389 LOW INCIDENCE OF LATE-ONSET GCA DURING THE FIRST YEAR IN PATIENTS WITH POLYMYALGIA RHEUMATICA — AN IMAGING-BASED STUDY
- Author
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Nielsen, A. W., primary, Hauge, E. M., additional, Hansen, I., additional, Dalsgaard Nielsen, B., additional, Kjær, G. G., additional, Blegvad-Nissen, J., additional, Rewers, K., additional, Sørensen, C. M., additional, Gormsen, L. C., additional, and Keller, K., additional
- Published
- 2024
- Full Text
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5. POS0399 DIAGNOSTIC PERFORMANCE OF HEAD AND NECK FDG-PET/MR IN NEW-ONSET GCA
- Author
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Nienhuis, P. H., primary, Dias, A. H., additional, Sørensen, C. M., additional, Keller, K., additional, Hansen, I., additional, Naeser, E., additional, Nyhuus Bendix Rasch, M., additional, Appelman, A. P. A., additional, Brouwer, E., additional, Slart, R. H. J. A., additional, Hauge, E. M., additional, Gormsen, L. C., additional, and Dalsgaard Nielsen, B., additional
- Published
- 2024
- Full Text
- View/download PDF
6. Empagliflozin inhibits increased Na influx in atrial cardiomyocytes of patients with HFpEF
- Author
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Trum, M, primary, Riechel, J, additional, Schollmeier, E, additional, Lebek, S, additional, Hegner, P, additional, Reuthner, K, additional, Heers, S, additional, Keller, K, additional, Wester, M, additional, Klatt, S, additional, Hamdani, N, additional, Provaznik, Z, additional, Schmid, C, additional, Maier, L S, additional, Arzt, M, additional, and Wagner, S, additional
- Published
- 2024
- Full Text
- View/download PDF
7. Temporal and regional trends of case-fatality in patients hospitalized with acute respiratory distress syndrome in Germany
- Author
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Sagoschen, I, primary, Keller, K, additional, Farmakis, I, additional, Lurz, P, additional, and Hobohm, L, additional
- Published
- 2024
- Full Text
- View/download PDF
8. Assessing PERT integration: a European survey on pulmonary embolism response teams
- Author
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Hobohm, L, primary, Keller, K, additional, Farmakis, I T, additional, Tichelbaecker, T, additional, Sagoschen, I, additional, Gori, T, additional, Lurz, P, additional, Konstantinides, S, additional, and Ahrens, I, additional
- Published
- 2024
- Full Text
- View/download PDF
9. Risk factors for intensive care admission in pediatric patients with COVID-19 - results of the German na-tionwide inpatient sample
- Author
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Keller, K, primary, Sagoschen, I, additional, Schmitt, V H, additional, Sivanathan, V, additional, Farmakis, I T, additional, Hahad, O, additional, Koelmel, S, additional, Schmidt, F P, additional, Espinola-Klein, C, additional, Konstantinides, S, additional, Munzel, T, additional, Lurz, P, additional, and Hobohm, L, additional
- Published
- 2024
- Full Text
- View/download PDF
10. Impacts of Hurricane Irma on Florida Bay Islands, Everglades National Park, USA
- Author
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Wingard, G. Lynn, Bergstresser, S. E., Stackhouse, B. L., Jones, M. C., Marot, M. E., Hoefke, K., Daniels, A., and Keller, K.
- Published
- 2020
11. Tranexamsäure reduziert perioperative Bluttransfusionen nach offener radikaler Zystektomie - eine Propensity-Score-Matched-Analyse
- Author
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Egen, L, Keller, K, Menold, H, Quan, A, Dempfle, C, Schöttler, J, Wessels, F, Meister, B, Worst, T, Westhoff, N, Kriegmair, M, Honeck, P, Michel, M, Kowalewski, K, Egen, L, Keller, K, Menold, H, Quan, A, Dempfle, C, Schöttler, J, Wessels, F, Meister, B, Worst, T, Westhoff, N, Kriegmair, M, Honeck, P, Michel, M, and Kowalewski, K
- Published
- 2024
12. Rücklaufquoten verschiedener Rekrutierungsstrategien bei einer Befragung von Hausärzt:innen zum Thema Entlassmanagement: Eine randomisierte Studie
- Author
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Keller, K, Peter, S, Piotrowski, A, Seliger, F, Mortsiefer, A, Linemann, CH, Scholten, N, Keller, K, Peter, S, Piotrowski, A, Seliger, F, Mortsiefer, A, Linemann, CH, and Scholten, N
- Published
- 2024
13. Clinical findings in adults with post-acute sequelae of COVID-19 in the second year after acute infection: population-based, nested case-control study
- Author
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Peter, RS, Nieters, A, Göpel, S, Merle, U, Steinacker, J, Deibert, P, Friedmann-Bette, B, Nieß, A, Müller, B, Schilling, C, Erz, G, Giesen, R, Götz, V, Keller, K, Maier, P, Matits, L, Parthé, S, Rehm, M, Schellenberg, J, Kräusslich, HG, Rothenbacher, D, Kern, WV, Peter, RS, Nieters, A, Göpel, S, Merle, U, Steinacker, J, Deibert, P, Friedmann-Bette, B, Nieß, A, Müller, B, Schilling, C, Erz, G, Giesen, R, Götz, V, Keller, K, Maier, P, Matits, L, Parthé, S, Rehm, M, Schellenberg, J, Kräusslich, HG, Rothenbacher, D, and Kern, WV
- Published
- 2024
14. A field test of compact active transponders for InSAR geodesy
- Author
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Meister, A., Balasis-Levinsen, J., Keller, K., Pedersen, M. R.V., Merryman Boncori, J. P., Jensen, M., Meister, A., Balasis-Levinsen, J., Keller, K., Pedersen, M. R.V., Merryman Boncori, J. P., and Jensen, M.
- Abstract
Compact active transponders (CATs) - also termed electronic corner reflectors - are compact electronic devices designed to receive, actively amplify and re-transmit a radar signal, e.g. a C-band radar signal received from a Sentinel-1 satellite. CATs can potentially be useful for a number of purposes, e.g. if co-located with geodetic infrastructure. However, CATs have only recently become commercially available, and therefore, the usability and long-term performance of CATs are not well known. In this study, two CATs are tested under realistic operating conditions for a period of 14 months, from July 2020 to September 2021. The displacement time series of the CATs are determined from a persistent scatterers interferometric synthetic aperture radar processing of four tracks of Sentinel-1A/-1B data with a passive corner reflector (CR) as the spatial reference. The displacement time series of the CATs are evaluated against a ground truth established from repeated levellings between the CR and the CATs. Based on the results of this study, it is found that a sudden vertical displacement of a CAT can be determined with an accuracy better than 1 cm, possibly a few millimetres. Furthermore, it is found that the mean vertical velocity of a CAT, calculated from 14 months of interferometric synthetic aperture radar displacement time series, can be determined with an accuracy of a few mm/year. Finally, the line of sight (LoS) phase error is generally found to be moderately correlated with temperature, with an instrument-specific linear relationship between LoS error and temperature ranging between approx. 0.1 and 0.2 mm/°C. This correlation between LoS phase error and temperature can in principle be used for instrument-specific calibrations, which is a topic that should be addressed in future studies.
- Published
- 2024
15. Fecal calprotectin and platelet count predict histologic disease activity in pediatric ulcerative colitis: results from a projection-predictive feature selection.
- Author
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Schiller, B., Wirthgen, E., Weber, F., Schiller, S., Radke, M., Claßen, M., Däbritz, J., Buderus, S., Bufler, P., Däbritz, J., Dammann, S., de Laffolie, J., Friedt, M., Hauer, A., Keller, K. M., Krahl, A., Laaß, M., Lang, T., Posovszky, C., and Rodeck, B.
- Subjects
ULCERATIVE colitis ,PLATELET count ,FEATURE selection ,CALPROTECTIN ,INFLAMMATORY bowel diseases - Abstract
Especially for pediatric patients, proxies of mucosal inflammation are needed. The Pediatric Ulcerative Colitis Activity Index (PUCAI) has been established to predict clinical and endoscopic disease activity. However, histologic inflammation might persist. We applied a special variable selection technique to predict histologic healing in pediatric ulcerative colitis (UC) as parsimoniously (but still as precisely) as possible. The retrospective analysis included data from two study cohorts, comprising 91 visits from 59 pediatric patients with UC. A Bayesian ordinal regression model was used in combination with a projection-predictive feature selection (PPFS) to identify a minimal subset of clinical and laboratory parameters sufficient for the prediction of histologic disease activity. Following the PPFS, CEDATA-GPGE patient registry data were analyzed to investigate the relevance of the selected predictors in relation to PUCAI and Physician Global Assessment (PGA) in up to 6697 patient visits. Fecal calprotectin (FC) and platelet count were identified as the minimal subset of predictors sufficient for prediction of histologic disease activity in pediatric UC. FC and platelet count also appeared to be associated with increasing disease activity as measured by PUCAI and PGA in the CEDATA-GPGE registry. Based on the selected model, predictions can be performed with a Shiny web app. Conclusion: Our statistical approach constitutes a reproducible and objective tool to select a minimal subset of the most informative parameters to predict histologic inflammation in pediatric UC. A Shiny app shows how physicians may predict the histologic activity in a user-friendly way using FC and platelet count. To generalize the findings, further prospective studies will be needed. What is Known: • Histologic healing is a major endpoint in the therapy of ulcerative colitis (UC). • The PUCAI score has been established to predict disease activity in pediatric UC but is not suitable for the prediction of histologic healing. What is New: • Our Bayesian ordinal regression model in combination with a projection-predictive feature selection is a reproducible and objective tool to select the minimal subset of clinical and laboratory parameters to predict histologic inflammation in pediatric UC. • Histologic inflammation in pediatric UC can be non-invasively predicted based on the combination of fecal calprotectin levels and platelet count. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
16. Increased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure
- Author
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Schwuchow-Thonke, S., Göbel, S., Emrich, T., Schmitt, V. H., Fueting, F., Klank, C., Escher, F., Schultheiss, H. P., Münzel, T., Keller, K., and Wenzel, P.
- Published
- 2021
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17. Buckle up!: Fahrsimulation als Zukunftstool der verkehrsmedizinischen Forschung
- Author
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Lange, A., Keller, K., and Lakämper, S.
- Published
- 2020
- Full Text
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18. The provisional OMERACT ultrasonography score for giant cell arteritis
- Author
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Dejaco, C, Ponte, C, Monti, S, Rozza, D, Scire, C, Terslev, L, Bruyn, G, Boumans, D, Hartung, W, Hocevar, A, Milchert, M, Dohn, U, Mukhtyar, C, Aschwanden, M, Bosch, P, Camellino, D, Chrysidis, S, Ciancio, G, D'Agostino, M, Daikeler, T, Dasgupta, B, De Miguel, E, Diamantopoulos, A, Duftner, C, Agueda, A, Fredberg, U, Hanova, P, Hansen, I, Hauge, E, Iagnocco, A, Inanc, N, Juche, A, Karalilova, R, Kawamoto, T, Keller, K, Keen, H, Kermani, T, Kohler, M, Koster, M, Luqmani, R, Macchioni, P, Mackie, S, Naredo, E, Nielsen, B, Ogasawara, M, Pineda, C, Schafer, V, Seitz, L, Tomelleri, A, Torralba, K, Van Der Geest, K, Warrington, K, Schmidt, W, Dejaco C., Ponte C., Monti S., Rozza D., Scire C. A., Terslev L., Bruyn G. A. W., Boumans D., Hartung W., Hocevar A., Milchert M., Dohn U. Mo., Mukhtyar C. B., Aschwanden M., Bosch P., Camellino D., Chrysidis S., Ciancio G., D'Agostino M. A., Daikeler T., Dasgupta B., De Miguel E., Diamantopoulos A. P., Duftner C., Agueda A., Fredberg U., Hanova P., Hansen I. To., Hauge E. -M., Iagnocco A., Inanc N., Juche A., Karalilova R., Kawamoto T., Keller K. K., Keen H. I., Kermani T. A., Kohler M. J., Koster M., Luqmani R. A., Macchioni P., Mackie S. L., Naredo E., Nielsen B. D., Ogasawara M., Pineda C., Schafer V. S., Seitz L., Tomelleri A., Torralba K. D., Van Der Geest K. S. M., Warrington K. J., Schmidt W. A., Dejaco, C, Ponte, C, Monti, S, Rozza, D, Scire, C, Terslev, L, Bruyn, G, Boumans, D, Hartung, W, Hocevar, A, Milchert, M, Dohn, U, Mukhtyar, C, Aschwanden, M, Bosch, P, Camellino, D, Chrysidis, S, Ciancio, G, D'Agostino, M, Daikeler, T, Dasgupta, B, De Miguel, E, Diamantopoulos, A, Duftner, C, Agueda, A, Fredberg, U, Hanova, P, Hansen, I, Hauge, E, Iagnocco, A, Inanc, N, Juche, A, Karalilova, R, Kawamoto, T, Keller, K, Keen, H, Kermani, T, Kohler, M, Koster, M, Luqmani, R, Macchioni, P, Mackie, S, Naredo, E, Nielsen, B, Ogasawara, M, Pineda, C, Schafer, V, Seitz, L, Tomelleri, A, Torralba, K, Van Der Geest, K, Warrington, K, Schmidt, W, Dejaco C., Ponte C., Monti S., Rozza D., Scire C. A., Terslev L., Bruyn G. A. W., Boumans D., Hartung W., Hocevar A., Milchert M., Dohn U. Mo., Mukhtyar C. B., Aschwanden M., Bosch P., Camellino D., Chrysidis S., Ciancio G., D'Agostino M. A., Daikeler T., Dasgupta B., De Miguel E., Diamantopoulos A. P., Duftner C., Agueda A., Fredberg U., Hanova P., Hansen I. To., Hauge E. -M., Iagnocco A., Inanc N., Juche A., Karalilova R., Kawamoto T., Keller K. K., Keen H. I., Kermani T. A., Kohler M. J., Koster M., Luqmani R. A., Macchioni P., Mackie S. L., Naredo E., Nielsen B. D., Ogasawara M., Pineda C., Schafer V. S., Seitz L., Tomelleri A., Torralba K. D., Van Der Geest K. S. M., Warrington K. J., and Schmidt W. A.
- Abstract
Objectives To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from -1.19 to -2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corr coeff 0.37-0.48). Conclusion We developed a provisional OGUS for potential use in clinical trials.
- Published
- 2023
19. Ordinal spaces
- Author
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Keller, K. and Petrov, E.
- Published
- 2020
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20. Non-specific rheumatic manifestations in patients with Hashimoto’s thyroiditis: a pilot cross-sectional study
- Author
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Giuffrida, G., Bagnato, G., Campennì, A., Giovinazzo, S., Keller, K. P., Alibrandi, A., Roberts, W. N., Trimarchi, F., and Ruggeri, R. M.
- Published
- 2020
- Full Text
- View/download PDF
21. Prevention of Late Adolescent Obesity in the College Environment: An Optimal Default Paradigm
- Author
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Loeb, Katherine L, Radnitz, C, Keller, K, Schwartz, M, Boutelle, K, and Marcus, S
- Subjects
Medical and Health Sciences ,Education ,Psychology and Cognitive Sciences ,Nutrition & Dietetics - Published
- 2014
22. Comorbidity burden assessed by the charlson comorbidity index and its influence on prognosis of patients with pulmonary embolism
- Author
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Keller, K, primary, Schmitt, V, additional, Espinola-Klein, C, additional, Munzel, T, additional, Konstantinides, S, additional, and Hobohm, L, additional
- Published
- 2023
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23. Cardiopulmonary exercise testing and echocardiography in the follow-up after acute pulmonary embolism
- Author
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Farmakis, I, primary, Valerio, L, additional, Barco, S, additional, Alsheimer, E, additional, Ewert, R, additional, Giannakoulas, G, additional, Hobohm, L, additional, Keller, K, additional, Mavromanoli, A C, additional, Rosenkranz, S, additional, Morris, T A, additional, Held, M, additional, Dumitrescu, D, additional, and Konstantinides, S, additional
- Published
- 2023
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24. Incidence of chronic thromboembolic pulmonary Hypertension after acute pulmonary embolism in real-world practice
- Author
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Hobohm, L, primary, Below, M, additional, Farmakis, I T, additional, Barco, S, additional, Munzel, T, additional, Konstantinides, S, additional, Keller, K, additional, and Paschke, L M, additional
- Published
- 2023
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25. Former SARS-CoV-2-Infection is related to decreased peak VO2 and exercise hyperten-sion in athletes
- Author
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Keller, K, primary, Friedrich, O, additional, Treiber, J, additional, Quermann, A, additional, and Friedmann-Bette, B, additional
- Published
- 2023
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26. Pulmonary hypertension associated with left heart disease among hospitalized patients: analysis of the Nationwide Inpatient Sample
- Author
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Farmakis, I, primary, Hobohm, L, additional, Christodoulou, K C, additional, Keller, K, additional, Schmidt, K H, additional, Valerio, L, additional, Konstantinides, S, additional, and Giannakoulas, G, additional
- Published
- 2023
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27. Incidence and risk factors of myocarditis in hospitalized patients with COVID-19 in Germany
- Author
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Keller, K, primary, Sagoschen, I, additional, Konstantinides, S, additional, Gori, T, additional, Munzel, T, additional, and Hobohm, L, additional
- Published
- 2023
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28. Sex differences in the clinical profile of individuals with prediabetes and type 2 diabetes mellitus in the general population - results from the Gutenberg Health Study
- Author
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Schmitt, V, primary, Prochaska, J, additional, Schulz, A, additional, Hahad, O, additional, Keller, K, additional, Hobohm, L, additional, Troebs, S O, additional, Koeck, T, additional, Michal, M, additional, Schuster, A, additional, Mueller-Nurasyid, M, additional, Lackner, K, additional, Munzel, T, additional, and Wild, P, additional
- Published
- 2023
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29. Effectiveness and safety of catheter-directed thrombolysis for acute pulmonary embolism: a systematic review and meta-analysis
- Author
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Catalani, F, primary, Furbringer-Schwarz, A, additional, Farmakis, I T, additional, Avgerinos, E D, additional, Bikdeli, B, additional, Fumagalli, R M, additional, Hobohm, L, additional, Keller, K, additional, Klok, F A, additional, Lang, I, additional, Piazza, G, additional, Valerio, L, additional, Kucher, N, additional, Konstantinides, S V, additional, and Barco, S, additional
- Published
- 2023
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30. Socioeconomic, health-care access and clinical determinants of disease severity in Multiple Sclerosis in Chile
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Ciampi, E, primary, Soler, B, additional, Uribe-San-Martin, R, additional, Jürgensen, L, additional, Guzman, I, additional, Keller, K, additional, Reyes, A, additional, Bravo-Grau, S, additional, Cruz, JP, additional, and Cárcamo, C, additional
- Published
- 2023
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31. Towards an effective and economic carrot fly trap: Progress report 1981–1985
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Städler, E., primary, Gfeller, F., additional, Keller, K., additional, and Philipsen, H., additional
- Published
- 2020
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32. Aktuelle Therapie der akuten Lungenembolie
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Keller, K. and Lankeit, M.
- Published
- 2019
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33. Robust abatement pathways to tolerable climate futures require immediate global action
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Lamontagne, J. R., Reed, P. M., Marangoni, G., Keller, K., and Garner, G. G.
- Published
- 2019
- Full Text
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34. Octave Spanning Supercontinuum Generation in Water at Multi-Kilohertz Repetition Rates
- Author
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Keller, K. R., primary, Rojas-Aedo, R., additional, Vanderhaegen, A., additional, Ludwig, M., additional, and Brida, D., additional
- Published
- 2023
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35. e‐Health‐based management of patients receiving oral anticoagulation therapy: results from the observational thrombEVAL study
- Author
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Prochaska, J.H., Göbel, S., Keller, K., Coldewey, M., Ullmann, A., Lamparter, H., Schulz, A., Schinzel, H., Bickel, C., Lauterbach, M., Michal, M., Hardt, R., Binder, H., Espinola‐Klein, C., Lackner, K.J., ten Cate, H., Münzel, T., and Wild, P.S.
- Published
- 2017
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36. Predicting root zone soil moisture with soil properties and satellite near-surface moisture data across the conterminous United States
- Author
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Baldwin, D., Manfreda, S., Keller, K., and Smithwick, E.A.H.
- Published
- 2017
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37. Hydrogels – a macroscopic approach based on microscopic physics
- Author
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Keller, K., primary, Ricken, T., additional, and Wallmersperger, T., additional
- Published
- 2019
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38. Greengenes: Chimera-checked 16S rRNA gene database and workbench compatible in ARB
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DeSantis, T.Z., Hugenholtz, P., Larsen, N., Rojas, M., Brodie, E.L, Keller, K., Huber, T., Dalevi, D., Hu, P., and Andersen, G.L.
- Subjects
Environmental sciences - Published
- 2006
39. Completed Genome Sequence of Dechloromonas aromatica: Analysis of a Microbe with Diverse Bioremediative Capability in Anaerobic Environments
- Author
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Coates, J.D., Kellaris, K.V., Feil, W.S., Feil, H., Achenbach, L.A., Chakraborty, R., Shang, C., Alm, E., Huang, K., Price, M., Keller, K., Trong, S., Bartolo, G. Di, Arkin, A., Lapidus, A., Richardson, P.M., Larimer, F.W., and O'Connor, S.M.
- Subjects
Complete genome Dechloromonas Aromatica - Published
- 2005
40. Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
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Kousathanas, A, Pairo-Castineira, E, Rawlik, K, Stuckey, A, Odhams, C, Walker, S, Russell, C, Malinauskas, T, Wu, Y, Millar, J, Shen, X, Elliott, K, Griffiths, F, Oosthuyzen, W, Morrice, K, Keating, S, Wang, B, Rhodes, D, Klaric, L, Zechner, M, Parkinson, N, Siddiq, A, Goddard, P, Donovan, S, Maslove, D, Nichol, A, Semple, M, Zainy, T, Maleady-Crowe, F, Todd, L, Salehi, S, Knight, J, Elgar, G, Chan, G, Arumugam, P, Patch, C, Rendon, A, Bentley, D, Kingsley, C, Kosmicki, J, Horowitz, J, Baras, A, Abecasis, G, Ferreira, M, Justice, A, Mirshahi, T, Oetjens, M, Rader, D, Ritchie, M, Verma, A, Fowler, T, Shankar-Hari, M, Summers, C, Hinds, C, Horby, P, Ling, L, Mcauley, D, Montgomery, H, Openshaw, P, Elliott, P, Walsh, T, Tenesa, A, Shelton, J, Shastri, A, Ye, C, Weldon, C, Filshtein-Sonmez, T, Coker, D, Symons, A, Esparza-Gordillo, J, Aslibekyan, S, Auton, A, Pathak, G, Karjalainen, J, Stevens, C, Andrews, S, Kanai, M, Cordioli, M, Polimanti, R, Pirinen, M, Harerimana, N, Veerapen, K, 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P., Vitart V., Yang J., Bretherick A. D., Hendry S. C., Law A., and Baillie J. K.
- Abstract
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease.
- Published
- 2022
41. A first update on mapping the human genetic architecture of COVID-19
- Author
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COVID-19 Host Genetics Initiative, Pathak, GA, Karjalainen, J, Stevens, C, Neale, BM, Daly, M, Ganna, A, Andrews, SJ, Kanai, M, Cordioli, M, Polimanti, R, Harerimana, N, Pirinen, M, Liao, RG, Chwialkowska, K, Trankiem, A, Balaconis, MK, Nguyen, H, Solomonson, M, Veerapen, K, Wolford, B, Roberts, G, Park, D, Ball, CA, Coignet, M, McCurdy, S, Knight, S, Partha, R, Rhead, B, Zhang, M, Berkowitz, N, Gaddis, M, Noto, K, Ruiz, L, Pavlovic, M, Hong, EL, Rand, K, Girshick, A, Guturu, H, Baltzell, AH, Niemi, MEK, Rahmouni, S, Guntz, J, Beguin, Y, Pigazzini, S, Nkambule, L, Georges, M, Moutschen, M, Misset, B, Darcis, G, Guiot, J, Azarzar, S, Gofflot, S, Claassen, S, Malaise, O, Huynen, P, Meuris, C, Thys, M, Jacques, J, Leonard, P, Frippiat, F, Giot, J-B, Sauvage, A-S, Frenckell, CV, Belhaj, Y, Lambermont, B, Nakanishi, T, Morrison, DR, Mooser, V, Richards, JB, Butler-Laporte, G, Forgetta, V, Li, R, Ghosh, B, Laurent, L, Belisle, A, Henry, D, Abdullah, T, Adeleye, O, Mamlouk, N, Kimchi, N, Afrasiabi, Z, Rezk, N, Vulesevic, B, Bouab, M, Guzman, C, Petitjean, L, Tselios, C, Xue, X, Afilalo, J, Afilalo, M, Oliveira, M, Brenner, B, Brassard, N, Durand, M, Schurr, E, Lepage, P, Ragoussis, J, Auld, D, Chassé, M, Kaufmann, DE, Lathrop, GM, Adra, D, Hayward, C, Glessner, JT, Shaw, DM, Campbell, A, Morris, M, Hakonarson, H, Porteous, DJ, Below, J, Richmond, A, Chang, X, Polikowski, H, Lauren, PE, Chen, H-H, Wanying, Z, Fawns-Ritchie, C, North, K, McCormick, JB, Glessner, JR, Gignoux, CR, Wicks, SJ, Crooks, K, Barnes, KC, Daya, M, Shortt, J, Rafaels, N, Chavan, S, Timmers, PRHJ, Wilson, JF, Tenesa, A, Kerr, SM, D’Mellow, K, Shahin, D, El-Sherbiny, YM, von Hohenstaufen, KA, Sobh, A, Eltoukhy, MM, Nkambul, L, Elhadidy, TA, Abd Elghafar, MS, El-Jawhari, JJ, Mohamed, AAS, Elnagdy, MH, Samir, A, Abdel-Aziz, M, Khafaga, WT, El-Lawaty, WM, Torky, MS, El-shanshory, MR, Yassen, AM, Hegazy, MAF, Okasha, K, Eid, MA, Moahmed, HS, Medina-Gomez, C, Ikram, MA, Uitterlinden, AG, Mägi, R, Milani, 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Colobrán, R, Martín-Nalda, A, Martínez, AP, Bernardo, D, Rojo, S, Fiz-López, A, Arribas, E, de la Cal-Sabater, P, Segura, T, González-Villa, E, Serrano-Heras, G, Martí-Fàbregas, J, Jiménez-Xarrié, E, de Felipe Mimbrera, A, Masjuan, J, García-Madrona, S, Domínguez-Mayoral, A, Villalonga, JM, Menéndez-Valladares, P, Chasman, DI, Sesso, HD, Manson, JE, Buring, JE, Ridker, PM, Franco, G, Davis, L, Lee, S, Priest, J, Sankaran, VG, van Heel, D, Biesecker, L, Kerchberger, VE, Baillie, JK, Pathak, Gita A., Karjalainen, Juha, Stevens, Christine, Neale, Benjamin M., Daly, Mark, Ganna, Andrea, Andrews, Shea J., Kanai, Masahiro, Cordioli, Mattia, Polimanti, Renato, Harerimana, Nadia, Pirinen, Matti, Liao, Rachel G., Chwialkowska, Karolina, Trankiem, Amy, Balaconis, Mary K., Nguyen, Huy, Solomonson, Matthew, Veerapen, Kumar, Wolford, Brooke, Roberts, Genevieve, Park, Danny, Ball, Catherine A., Coignet, Marie, McCurdy, Shannon, Knight, Spencer, Partha, Raghavendran, Rhead, Brooke, Zhang, Miao, Berkowitz, Nathan, Gaddis, Michael, Noto, Keith, Ruiz, Luong, Pavlovic, Milo, Hong, Eurie L., Rand, Kristin, Girshick, Ahna, Guturu, Harendra, Baltzell, Asher Haug, Niemi, Mari E. K., Rahmouni, Souad, Guntz, Julien, Beguin, Yve, Pigazzini, Sara, Nkambule, Lindokuhle, Georges, Michel, Moutschen, Michel, Misset, Benoit, Darcis, Gille, Guiot, Julien, Azarzar, Samira, Gofflot, Stéphanie, Claassen, Sabine, Malaise, Olivier, Huynen, Pascale, Meuris, Christelle, Thys, Marie, Jacques, Jessica, Léonard, Philippe, Frippiat, Frederic, Giot, Jean-Baptiste, Sauvage, Anne-Sophie, Frenckell, Christian Von, Belhaj, Yasmine, Lambermont, Bernard, Nakanishi, Tomoko, Morrison, David R., Mooser, Vincent, Richards, J. Brent, Butler-Laporte, Guillaume, Forgetta, Vincenzo, Li, Rui, Ghosh, Biswarup, Laurent, Laetitia, Belisle, Alexandre, Henry, Danielle, Abdullah, Tala, Adeleye, Olumide, Mamlouk, Noor, Kimchi, Nofar, Afrasiabi, Zaman, Rezk, Nardin, Vulesevic, Branka, Bouab, Meriem, Guzman, Charlotte, Petitjean, Loui, Tselios, Chri, Xue, Xiaoqing, Afilalo, Jonathan, Afilalo, Marc, Oliveira, Maureen, Brenner, Bluma, Brassard, Nathalie, Durand, Madeleine, Schurr, Erwin, Lepage, Pierre, Ragoussis, Jianni, Auld, Daniel, Chassé, Michaël, Kaufmann, Daniel E., Lathrop, G. Mark, Adra, Darin, Hayward, Caroline, Glessner, Joseph T., Shaw, Douglas M., Campbell, Archie, Morris, Marcela, Hakonarson, Hakon, Porteous, David J., Below, Jennifer, Richmond, Anne, Chang, Xiao, Polikowski, Hannah, Lauren, Petty E., Chen, Hung-Hsin, Wanying, Zhu, Fawns-Ritchie, Chloe, North, Kari, McCormick, Joseph B., Glessner, Joseph R., Gignoux, Christopher R., Wicks, Stephen J., Crooks, Kristy, Barnes, Kathleen C., Daya, Michelle, Shortt, Jonathan, Rafaels, Nichola, Chavan, Sameer, Timmers, Paul R. H. J., Wilson, James F., Tenesa, Albert, Kerr, Shona M., D’Mellow, Kenton, Shahin, Doaa, El-Sherbiny, Yasser M., von Hohenstaufen, Kathrin Aprile, Sobh, Ali, Eltoukhy, Madonna M., Nkambul, Lindokuhle, Elhadidy, Tamer A., Abd Elghafar, Mohamed S., El-Jawhari, Jehan J., Mohamed, Attia A. S., Elnagdy, Marwa H., Samir, Amr, Abdel-Aziz, Mahmoud, Khafaga, Walid T., El-Lawaty, Walaa M., Torky, Mohamed S., El-shanshory, Mohamed R., Yassen, Amr M., Hegazy, Mohamed A. F., Okasha, Kamal, Eid, Mohammed A., Moahmed, Hanteera S., Medina-Gomez, Carolina, Ikram, M. Arfan, Uitterlinden, Andre G., Mägi, Reedik, Milani, Lili, Metspalu, Andre, Laisk, Triin, Läll, Kristi, Lepamets, Maarja, Esko, Tõnu, Reimann, Ene, Naaber, Paul, Laane, Edward, Pesukova, Jaana, Peterson, Pärt, Kisand, Kai, Tabri, Jekaterina, Allos, Raili, Hensen, Kati, Starkopf, Joel, Ringmets, Inge, Tamm, Anu, Kallaste, Anne, Alavere, Helene, Metsalu, Kristjan, Puusepp, Mairo, Batini, Chiara, Tobin, Martin D., Venn, Laura D., Lee, Paul H., Shrine, Nick, Williams, Alexander T., Guyatt, Anna L., John, Catherine, Packer, Richard J., Ali, Altaf, Free, Robert C., Wang, Xueyang, Wain, Louise V., Hollox, Edward J., Bee, Catherine E., Adams, Emma L., Palotie, Aarno, Ripatti, Samuli, Ruotsalainen, Sanni, Kristiansson, Kati, Koskelainen, Sami, Perola, Marku, Donner, Kati, Kivinen, Katja, Kaunisto, Mari, Rivolta, Carlo, Bochud, Pierre-Yve, Bibert, Stéphanie, Boillat, Noémie, Nussle, Semira Gonseth, Albrich, Werner, Quinodoz, Mathieu, Kamdar, Dhryata, Suh, Noémie, Neofytos, Dionysio, Erard, Véronique, Voide, Cathy, Friolet, R., Vollenweider, P., Pagani, J. L., Oddo, M., zu Bentrup, F. Meyer, Conen, A., Clerc, O., Marchetti, O., Guillet, A., Guyat-Jacques, C., Foucras, S., Rime, M., Chassot, J., Jaquet, M., Viollet, R. Merlet, Lannepoudenx, Y., Portopena, L., Bochud, P. Y., Desgranges, F., Filippidis, P., Guéry, B., Haefliger, D., Kampouri, E. E., Manuel, O., Munting, A., Papadimitriou-Olivgeris, M., Regina, J., Rochat-Stettler, L., Suttels, V., Tadini, E., Tschopp, J., Van Singer, M., Viala, B., Boillat-Blanco, N., Brahier, T., Hügli, O., Meuwly, J. Y., Pantet, O., Gonseth Nussle, S., Bochud, M., D’Acremont, V., Estoppey Younes, S., Albrich, W. C., Suh, N., Cerny, A., O’Mahony, L., von Mering, C., Frischknecht, M., Kleger, G-R., Filipovic, M., Kahlert, C. R., Wozniak, H., Negro, T. Rochat, Pugin, J., Bouras, K., Knapp, C., Egger, T., Perret, A., Montillier, P., di Bartolomeo, C., Barda, B., de Cid, Rafael, Carreras, Anna, Moreno, Victor, Kogevinas, Manoli, Galván-Femenía, Iván, Blay, Natalia, Farré, Xavier, Sumoy, Lauro, Cortés, Beatriz, Mercader, Josep Maria, Guindo-Martinez, Marta, Torrents, David, Garcia-Aymerich, Judith, Castaño-Vinyals, Gemma, Dobaño, Carlota, Gori, Marco, Renieri, Alessandra, Mari, Francesca, Mondelli, Mario Umberto, Castelli, Francesco, Vaghi, Massimo, Rusconi, Stefano, Montagnani, Francesca, Bargagli, Elena, Franchi, Federico, Mazzei, Maria Antonietta, Cantarini, Luca, Tacconi, Danilo, Feri, Marco, Scala, Raffaele, Spargi, Genni, Nencioni, Cesira, Bandini, Maria, Caldarelli, Gian Piero, Canaccini, Anna, Ognibene, Agostino, D’Arminio Monforte, Antonella, Girardis, Massimo, Antinori, Andrea, Francisci, Daniela, Schiaroli, Elisabetta, Scotton, Pier Giorgio, Panese, Sandro, Scaggiante, Renzo, Monica, Matteo Della, Capasso, Mario, Fiorentino, Giuseppe, Castori, Marco, Aucella, Filippo, Biagio, Antonio Di, Masucci, Luca, Valente, Serafina, Mandalà, Marco, Zucchi, Patrizia, Giannattasio, Ferdinando, Coviello, Domenico A., Mussini, Cristina, Tavecchia, Luisa, Crotti, Lia, Rizzi, Marco, Rovere, Maria Teresa La, Sarzi-Braga, Simona, Bussotti, Maurizio, Ravaglia, Sabrina, Artuso, Rosangela, Perrella, Antonio, Romani, Davide, Bergomi, Paola, Catena, Emanuele, Vincenti, Antonella, Ferri, Claudio, Grassi, Davide, Pessina, Gloria, Tumbarello, Mario, Pietro, Massimo Di, Sabrina, Ravaglia, Luchi, Sauro, Furini, Simone, Dei, Simona, Benetti, Elisa, Picchiotti, Nicola, Sanarico, Maurizio, Ceri, Stefano, Pinoli, Pietro, Raimondi, Francesco, Biscarini, Filippo, Stella, Alessandra, Zguro, Kristina, Capitani, Katia, Tanfoni, Marco, Fallerini, Chiara, Daga, Sergio, Baldassarri, Margherita, Fava, Francesca, Frullanti, Elisa, Valentino, Floriana, Doddato, Gabriella, Giliberti, Annarita, Tita, Rossella, Amitrano, Sara, Bruttini, Mirella, Croci, Susanna, Meloni, Ilaria, Mencarelli, Maria Antonietta, Rizzo, Caterina Lo, Pinto, Anna Maria, Beligni, Giada, Tommasi, Andrea, Sarno, Laura Di, Palmieri, Maria, Carriero, Miriam Lucia, Alaverdian, Diana, Busani, Stefano, Bruno, Raffaele, Vecchia, Marco, Belli, Mary Ann, Mantovani, Stefania, Ludovisi, Serena, Quiros-Roldan, Eugenia, Antoni, Melania Degli, Zanella, Isabella, Siano, Matteo, Emiliozzi, Arianna, Fabbiani, Massimiliano, Rossetti, Barbara, Bergantini, Laura, D’Alessandro, Miriana, Cameli, Paolo, Bennett, David, Anedda, Federico, Marcantonio, Simona, Scolletta, Sabino, Guerrini, Susanna, Conticini, Edoardo, Frediani, Bruno, Spertilli, Chiara, Donati, Alice, Guidelli, Luca, Corridi, Marta, Croci, Leonardo, Piacentini, Paolo, Desanctis, Elena, Cappelli, Silvia, Verzuri, Agnese, Anemoli, Valentina, Pancrazzi, Alessandro, Lorubbio, Maria, Miraglia, Federica Gaia, Venturelli, Sophie, Cossarizza, Andrea, Vergori, Alessandra, Gabrieli, Arianna, Riva, Agostino, Paciosi, Francesco, Andretta, Francesca, Gatti, Francesca, Parisi, Saverio Giuseppe, Baratti, Stefano, Piscopo, Carmelo, Russo, Roberta, Andolfo, Immacolata, Iolascon, Achille, Carella, Massimo, Merla, Giuseppe, Squeo, Gabriella Maria, Raggi, Pamela, Marciano, Carmen, Perna, Rita, Bassetti, Matteo, Sanguinetti, Maurizio, Giorli, Alessia, Salerni, Lorenzo, Parravicini, Pierpaolo, Menatti, Elisabetta, Trotta, Tullio, Coiro, Gabriella, Lena, Fabio, Martinelli, Enrico, Mancarella, Sandro, Gabbi, Chiara, Maggiolo, Franco, Ripamonti, Diego, Bachetti, Tiziana, Suardi, Claudia, Parati, Gianfranco, Bottà, Giordano, Domenico, Paolo Di, Rancan, Ilaria, Bianchi, Francesco, Colombo, Riccardo, Barbieri, Chiara, Acquilini, Donatella, Andreucci, Elena, Segala, Francesco Vladimiro, Tiseo, Giusy, Falcone, Marco, Lista, Mirjam, Poscente, Monica, Vivo, Oreste De, Petrocelli, Paola, Guarnaccia, Alessandra, Baroni, Silvia, van Heel, David A., Hunt, Karen A., Trembath, Richard C., Huang, Qin Qin, Martin, Hilary C., Mason, Dan, Trivedi, Bhavi, Wright, John, Finer, Sarah, Akhtar, Shaheen, Anwar, Mohammad, Arciero, Elena, Ashraf, Samina, Breen, Gerome, Chung, Raymond, Curtis, Charles J., Chowdhury, Maharun, Colligan, Grainne, Deloukas, Pano, Durham, Ceri, Griffiths, Chri, Hurles, Matt, Hussain, Shapna, Islam, Kamrul, Khan, Ahsan, Khan, Amara, Lavery, Cath, Lee, Sang Hyuck, Lerner, Robin, MacArthur, Daniel, MacLaughlin, Bev, Martin, Hilary, Miah, Shefa, Newman, Bill, Safa, Nishat, Tahmasebi, Farah, Griffiths, Christopher J., Smith, Albert V., Boughton, Andrew P., Li, Kevin W., LeFaive, Jonathon, Annis, Aubrey, Niavarani, Ahmadreza, Aliannejad, Rasoul, Sharififard, Bahareh, Amirsavadkouhi, Ali, Naderpour, Zeinab, Tadi, Hengameh Ansari, Aleagha, Afshar Etemadi, Ahmadi, Saeideh, Moghaddam, Seyed Behrooz Mohseni, Adamsara, Alireza, Saeedi, Morteza, Abdollahi, Hamed, Hosseini, Abdolmajid, Chariyavilaskul, Pajaree, Jantarabenjakul, Watsamon, Hirankarn, Nattiya, Chamnanphon, Monpat, Suttichet, Thitima B., Shotelersuk, Vorasuk, Pongpanich, Monnat, Phokaew, Chureerat, Chetruengchai, Wanna, Putchareon, Opa, Torvorapanit, Pattama, Puthanakit, Thanyawee, Suchartlikitwong, Pintip, Nilaratanakul, Voraphoj, Sodsai, Pimpayao, Brumpton, Ben M., Hveem, Kristian, Willer, Cristen, Zhou, Wei, Rogne, Tormod, Solligard, Erik, Åsvold, Bjørn Olav, Franke, Lude, Boezen, Marike, Deelen, Patrick, Claringbould, Annique, Lopera, Esteban, Warmerdam, Robert, Vonk, Judith. M., van Blokland, Irene, Lanting, Pauline, Ori, Anil P. S., Feng, Yen-Chen Anne, Mercader, Josep, Weiss, Scott T., Karlson, Elizabeth W., Smoller, Jordan W., Murphy, Shawn N., Meigs, James B., Woolley, Ann E., Green, Robert C., Perez, Emma F., Zöllner, Sebastian, Wang, Jiongming, Beck, Andrew, Sloofman, Laura G., Ascolillo, Steven, Sebra, Robert P., Collins, Brett L., Levy, Te, Buxbaum, Joseph D., Sealfon, Stuart C., Jordan, Daniel M., Thompson, Ryan C., Gettler, Kyle, Chaudhary, Kumardeep, Belbin, Gillian M., Preuss, Michael, Hoggart, Clive, Choi, Sam, Underwood, Slayton J., Salib, Irene, Britvan, Bari, Keller, Katherine, Tang, Lara, Peruggia, Michael, Hiester, Liam L., Niblo, Kristi, Aksentijevich, Alexandra, Labkowsky, Alexander, Karp, Avromie, Zlatopolsky, Menachem, Zyndorf, Marissa, Charney, Alexander W., Beckmann, Noam D., Schadt, Eric E., Abul-Husn, Noura S., Cho, Judy H., Itan, Yuval, Kenny, Eimear E., Loos, Ruth J. F., Nadkarni, Girish N., Do, Ron, O’Reilly, Paul, Huckins, Laura M., Ferreira, Manuel A. R., Abecasis, Goncalo R., Leader, Joseph B., Cantor, Michael N., Justice, Anne E., Carey, Dave J., Chittoor, Geetha, Josyula, Navya Shilpa, Kosmicki, Jack A., Horowitz, Julie E., Baras, Ari, Gass, Matthew C., Yadav, Ashish, Mirshahi, Tooraj, Hottenga, Jouke Jan, Bartels, Meike, de geus, Eco E. J. C., Nivard, Michel M. G., Verma, Anurag, Ritchie, Marylyn D., Rader, Daniel, Li, Binglan, Verma, Shefali S., Lucas, Anastasia, Bradford, Yuki, Abedalthagafi, Malak, Alaamery, Manal, Alshareef, Abdulraheem, Sawaji, Mona, Massadeh, Salam, AlMalik, Abdulaziz, Alqahtani, Saleh, Baraka, Dona, Harthi, Fawz Al, Alsolm, Ebtehal, Safieh, Leen Abu, Alowayn, Albandary M., Alqubaishi, Fatimah, Mutairi, Amal Al, Mangul, Serghei, Almutairi, Mansour, Aljawini, Nora, Albesher, Nour, Arabi, Yaseen M., Mahmoud, Ebrahim S., Khattab, Amin K., Halawani, Roaa T., Alahmadey, Ziab Z., Albakri, Jehad K., Felemban, Walaa A., Suliman, Bandar A., Hasanato, Rana, Al-Awdah, Laila, Alghamdi, Jahad, AlZahrani, Deema, AlJohani, Sameera, Al-Afghani, Hani, AlDhawi, Nouf, AlBardis, Hadeel, Alkwai, Sarah, Alswailm, Moneera, Almalki, Faisal, Albeladi, Maha, Almohammed, Iman, Barhoush, Eman, Albader, Anoud, Alotaibi, Sara, Alghamdi, Bader, Jung, Junghyun, fawzy, Mohammad S., Alrashed, May, Zeberg, Hugo, Nkambul, Lindo, Frithiof, Robert, Hultström, Michael, Lipcsey, Miklo, Tardif, Nicola, Rooyackers, Olav, Grip, Jonathan, Maricic, Tomislav, Helgeland, Øyvind, Magnus, Per, Trogstad, Lill-Iren S., Lee, Yunsung, Harris, Jennifer R., Mangino, Massimo, Spector, Tim D., Emma, Duncan, Moutsianas, Louka, Caulfield, Mark J., Scott, Richard H., Kousathanas, Athanasio, Pasko, Dorota, Walker, Susan, Stuckey, Alex, Odhams, Christopher A., Rhodes, Daniel, Fowler, Tom, Rendon, Augusto, Chan, Georgia, Arumugam, Prabhu, Karczewski, Konrad J., Martin, Alicia R., Wilson, Daniel J., Spencer, Chris C. A., Crook, Derrick W., Wyllie, David H., O’Connell, Anne Marie, Atkinson, Elizabeth G., Tsuo, Kristin, Baya, Nikola, Turley, Patrick, Gupta, Rahul, Walters, Raymond K., Palmer, Duncan S., Sarma, Gopal, Cheng, Nathan, Lu, Wenhan, Churchhouse, Claire, Goldstein, Jacqueline I., King, Daniel, Seed, Cotton, Daly, Mark J., Finucane, Hilary, Bryant, Sam, Satterstrom, F. Kyle, Band, Gavin, Earle, Sarah G., Lin, Shang-Kuan, Arning, Nicola, Koelling, Nil, Armstrong, Jacob, Rudkin, Justine K., Callier, Shawneequa, Cusick, Caroline, Soranzo, Nicole, Zhao, Jing Hua, Danesh, John, Angelantonio, Emanuele Di, Butterworth, Adam S., Sun, Yan V., Huffman, Jennifer E., Cho, Kelly, O’Donnell, Christopher J., Tsao, Phil, Gaziano, J. Michael, Peloso, Gina, Ho, Yuk-Lam, Smieszek, Sandra P., Polymeropoulos, Christo, Polymeropoulos, Vasilio, Polymeropoulos, Mihael H., Przychodzen, Bartlomiej P., Fernandez-Cadenas, Israel, Planas, Anna M., Perez-Tur, Jordi, Llucià-Carol, Laia, Cullell, Natalia, Muiño, Elena, Cárcel-Márquez, Jara, DeDiego, Marta L., Iglesias, Lara Lloret, Soriano, Alex, Rico, Veronica, Agüero, Daiana, Bedini, Josep L., Lozano, Francisco, Domingo, Carlo, Robles, Veronica, Ruiz-Jaén, Francisca, Márquez, Leonardo, Gomez, Juan, Coto, Eliecer, Albaiceta, Guillermo M., García-Clemente, Marta, Dalmau, David, Arranz, Maria J., Dietl, Beatriz, Serra-Llovich, Alex, Soler, Pere, Colobrán, Roger, Martín-Nalda, Andrea, Martínez, Alba Parra, Bernardo, David, Rojo, Silvia, Fiz-López, Aida, Arribas, Elisa, de la Cal-Sabater, Paloma, Segura, Tomá, González-Villa, Esther, Serrano-Heras, Gemma, Martí-Fàbregas, Joan, Jiménez-Xarrié, Elena, de Felipe Mimbrera, Alicia, Masjuan, Jaime, García-Madrona, Sebastian, Domínguez-Mayoral, Anna, Villalonga, Joan Montaner, Menéndez-Valladares, Paloma, Chasman, Daniel I., Sesso, Howard D., Manson, JoAnn E., Buring, Julie E., Ridker, Paul M., Franco, Giulianini, Davis, Lea, Lee, Sulggi, Priest, Jame, Sankaran, Vijay G., van Heel, David, Biesecker, Le, Kerchberger, V. Eric, Baillie, J. Kenneth, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Biological Psychology, APH - Mental Health, AMS - Sports, AMS - Ageing & Vitality, APH - Methodology, Mccurdy, Shannon, Mccormick, Joseph B., Macarthur, Daniel, Maclaughlin, Bev, Lefaive, Jonathon, Almalik, Abdulaziz, Alzahrani, Deema, Aljohani, Sameera, Aldhawi, Nouf, Albardis, Hadeel, Fawzy, Mohammad S., Dediego, Marta L., Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), University of Zurich, COVID-19 Host Genetics Initiative, Barcelona Supercomputing Center, COVID-19 Genetics Initiative, including authors, Institute for Molecular Medicine Finland, and Data Science Genetic Epidemiology Lab
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Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC] ,Quantitative Trait Loci ,MUC5B PROMOTER POLYMORPHISM ,Genome-wide association studies ,COVID-19 (Malaltia) ,UFSP13-7 Evolution in Action: From Genomes to Ecosystems ,COVID-19 (Disease) ,Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA ,SDG 3 - Good Health and Well-being ,Humans ,genetics ,Genetic variation ,Genomes ,Medicinsk genetik ,1000 Multidisciplinary ,Multidisciplinary ,Chromosome Mapping ,COVID-19 ,Human Genetics ,10124 Institute of Molecular Life Sciences ,covid-19 ,3121 General medicine, internal medicine and other clinical medicine ,570 Life sciences ,biology ,Medical Genetics - Abstract
Matters arising from: Mapping the human genetic architecture of COVID-19 Original Article published on 08 July 2021 https://www.nature.com/articles/s41586-021-03767-x The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity. Here we present meta-analyses bringing together 60 studies from 25 countries (Fig. 1 and Supplementary Table 1) for three COVID-19-related phenotypes: (1) individuals critically ill with COVID-19 on the basis of requiring respiratory support in hospital or who died as a consequence of the disease (9,376 cases, of which 3,197 are new in this data release, and 1,776,645 control individuals); (2) individuals with moderate or severe COVID-19 defined as those hospitalized due to symptoms associated with the infection (25,027 cases, 11,386 new and 2,836,272 control individuals); and (3) all cases with reported SARS-CoV-2 infection regardless of symptoms (125,584 cases, 76,022 new and 2,575,347 control individuals). Most studies have reported results before the roll out of the COVID-19 vaccination campaign. An overview of the study design is provided in Supplementary Fig. 1. We found a total of 23 genome-wide significant loci (P
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42. POS0700 METABOLIC AND MORPHOLOGIC PET/MR FEATURES IN CRANIAL GIANT CELL ARTERITIS
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Nienhuis, P., primary, Sørensen, C. M., additional, Keller, K., additional, Hansen, I., additional, Naeser, E., additional, Nyhuus Bendix Rasch, M., additional, Brouwer, E., additional, Slart, R., additional, Dias, A., additional, Appelman, A., additional, Hauge, E. M., additional, Gormsen, L. C., additional, and Dalsgaard Nielsen, B., additional
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43. Reperfusion therapies in elderly and frail patients with pulmonary embolism: a nationwide inpatient sample analysis
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Farmakis, I, primary, Barco, S, additional, Giannakoulas, G, additional, Keller, K, additional, Valerio, L, additional, Ahrens, I, additional, Konstantinides, S V, additional, and Hobohm, L, additional
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- 2023
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44. Use of advanced therapies for pulmonary embolism among pregnant or postpartum women
- Author
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Farmakis, I, primary, Barco, S, additional, Giannakoulas, G, additional, Keller, K, additional, Valerio, L, additional, Konstantinides, S V, additional, and Hobohm, L, additional
- Published
- 2023
- Full Text
- View/download PDF
45. Multidisciplinary Pulmonary Embolism Response Team (PERT) a propensity score matched single centre experience from Germany
- Author
-
Sagoschen, I, primary, Scibior, B, additional, Farmakis, I T, additional, Munzel, T, additional, Keller, K, additional, Konstantinides, S, additional, and Hobohm, L, additional
- Published
- 2023
- Full Text
- View/download PDF
46. Mixed-Methods-Evaluation eines neu entwickelten Question Prompt Sheets für Menschen mit Koronarer Herzkrankheit und psychischen und/oder kognitiven Komorbiditäten: Eine Anwendung des Technologieakzeptanzmodells
- Author
-
Keller, K, Leminski, C, Werner, B, Bach, L, Peter, S, Schulz-Nieswandt, F, Jessen, F, Albus, C, Pfaff, H, Keller, K, Leminski, C, Werner, B, Bach, L, Peter, S, Schulz-Nieswandt, F, Jessen, F, Albus, C, and Pfaff, H
- Published
- 2023
47. Barrieren und Förderfaktoren für ein sektorenübergreifendes, interprofessionelles Entlasskonzept - Ergebnisse aus Workshops mit niedergelassenen Ärzt*innen
- Author
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Peter, S, Piotrowski, A, Scholten, N, Hoffmann, J, Keller, K, Brinkkötter, PT, Burst, V, Mortsiefer, A, Peter, S, Piotrowski, A, Scholten, N, Hoffmann, J, Keller, K, Brinkkötter, PT, Burst, V, and Mortsiefer, A
- Published
- 2023
48. Wie können Re-Hospitalisierungen vermieden werden? Ergebnisse eines Workshops mit Hausärzt:innen zu einem geplanten, intersektoralen Krankenhausentlassungskonzept
- Author
-
Peter, S, Piotrowski, A, Hoffman, J, Keller, K, Scholten, N, Brinkkötter, P, Burst, V, Mortsiefer, A, Peter, S, Piotrowski, A, Hoffman, J, Keller, K, Scholten, N, Brinkkötter, P, Burst, V, and Mortsiefer, A
- Published
- 2023
49. Impulse für ein sektorenübergreifendes, interprofessionelles Entlassungskonzept - Ergebnisse aus Workshops mit niedergelassenen Ärzt*innen (eliPfad-Projekt)
- Author
-
Peter, S, Piotrowski, A, Scholten, N, Hoffmann, J, Keller, K, Mortsiefer, A, Peter, S, Piotrowski, A, Scholten, N, Hoffmann, J, Keller, K, and Mortsiefer, A
- Published
- 2023
50. A model structure for interfacial phase change memories: Epitaxial trigonal Ge1Sb2Te4
- Author
-
Hardtdegen, H., Rieß, S., Schuck, M., Keller, K., Jost, P., Du, H., Bornhöfft, M., Schwedt, A., Mussler, G., v.d. Ahe, M., Mayer, J., Roth, G., Grützmacher, D., and Mikulics, M.
- Published
- 2016
- Full Text
- View/download PDF
Catalog
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