7 results on '"Keling Xiao"'
Search Results
2. Cerebral hypometabolism mediates the effect of stroke volume on cognitive impairment in heart failure patients
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Chong Zheng, Yadong Cui, Shanshan Gu, Shaozhen Yan, Bixiao Cui, Tianbin Song, Jing Li, Jin Si, Keling Xiao, Qi Ge, Yang Yang, Yun Zhou, Xiang Li, and Jie Lu
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Heart failure ,Stroke volume ,Cerebral glucose metabolism ,18F‐FDG PET/MR ,Cognitive impairment ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims The present study aimed to phenotype the cerebral structural and glucose metabolic alterations in patients with heart failure (HF) using simultaneous positron emission tomography (PET)/magnetic resonance (MR) and to investigate their relationship to cardiac biomarkers and cognitive performance. Methods and results Forty‐two HF patients caused by ischaemic heart disease (mean age 67.2 ± 10.4, 32 males) and 32 age‐ and sex‐matched healthy volunteers (mean age 61.3 ± 4.8, 18 males) were included in this study. Participants underwent simultaneous cerebral fluorine‐18 (18F) fluorodeoxyglucose PET/MR followed by cardiac MR scan, and neuropsychological scores were obtained to assess cognitive performance. The grey matter volume (GMV) and standardized uptake value ratio (SUVR) were calculated to examine cerebral structural and metabolic alterations. Cardiac biomarkers included cardiac MR parameters and cardiac serum laboratory tests. Mediation analysis was performed to explore the associations among cerebral alterations, cardiac biomarkers, and cognitive performance. HF patients demonstrated notable cognitive impairment compared with normal controls (P
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- 2024
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3. Prognostic Value of Normal Thyroid Stimulating Hormone in Long-Term Mortality in Patients With STEMI
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Lijie Sun, Keling Xiao, Zupei Miao, Yinghua Zhang, Jin Si, Ning Shi, Haoyu Zhang, Ting Zhao, and Jing Li
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thyroid stimulating hormone ,ST-segment elevation myocardial infarction ,mortality ,prognosis ,coronary artery disease ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
BackgroundAlthough within the normal range, thyroid stimulating hormone (TSH) levels are associated with cardio-metabolic disorders and have an effect on the cardiovascular system. The aim of our study was to assess the prognostic value of normal TSH on long-term mortality in patients with ST-segment elevation myocardial infarction (STEMI).MethodsConsecutive STEMI patients who had a TSH level within the normal range (0.55–4.78 μIU/ml) were enrolled from November 2013 to December 2018. Patients were stratified into three groups depending on the tertile of TSH level, and all-cause mortality and cardiac death were compared. TSH concentrations associated with risk of all-cause mortality were evaluated in a continuous scale (restricted cubic splines) and the Cox proportional hazards regression model.ResultsA total of 1,203 patients with STEMI were eligible for analysis. During a median follow-up of 39 months, patients in the 3rd tertile group had higher all-cause mortality (20.1% vs. 12.2% and 14.3%, p = 0.006) and cardiac death (15.4% vs. 7.7% and 12.3%, p = 0.001) as compared to the 1st and 2nd tertile groups. The Cox proportional hazards model showed that TSH was an independent predictor on long-term all-cause mortality (HR: 1.248, 95% CI: 1.046–1.490, p = 0.014). However, subgroup analysis indicated that TSH (HR: 1.313, 95% CI: 1.063–1.623, p = 0.012) was only significantly associated with long-term all-cause mortality in the patients without emergency reperfusion therapy. Restricted cubic spline analyses showed a linear relationship between TSH concentrations and all-cause mortality (P for non-linearity = 0.659).ConclusionsA Higher TSH level - even in a normal range is associated with long-term mortality in patients with STEMI, proposing an additional indication to identify STEMI patients with poor prognosis.
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- 2022
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4. Air pollution and recurrence of cardiovascular events after ST-segment elevation myocardial infarction
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Haoyu Zhang, Ming Yi, Yang Wang, Yinghua Zhang, Keling Xiao, Jin Si, Ning Shi, Lijie Sun, Zupei Miao, Ting Zhao, Xipeng Sun, Zhi Liu, Jing Gao, and Jing Li
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Air Pollutants ,Air Pollution ,Nitrogen Dioxide ,Humans ,ST Elevation Myocardial Infarction ,Environmental Exposure ,Cardiology and Cardiovascular Medicine ,Retrospective Studies - Abstract
The effects of air pollution on discharged patients after ST-segment elevation myocardial infarction (STEMI) still remain uncertain. We examined the association between air pollutants and recurrent cardiovascular events in STEMI survivors.A retrospective cohort of 1641 discharged patients after STEMI was established in 2013 and followed until the end of 2019. Concentrations of air pollutants including fine particles2.5 μm aerodynamic diameter (PMCompared with the first exposure quartile, for short-term exposure, hazard ratios (HRs) of recurrent cardiovascular events associated with the fourth exposure quartiles of PMShort- and long-term exposure to air pollutants except ozone increases the risks of recurrent cardiovascular events in STEMI survivors. Better environmental policies and secondary prevention strategies should be developed to protect STEMI survivors as a susceptible population.
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- 2022
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5. The Effects of Multiple Parameters on Initial Apparent Viscosity and Rheological Behavior in a Liquid-Phase Paddy Field
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Lunqing Sun, Yuxuan Pan, Yongwei Wang, Keling Xiao, Jun Wang, Yiyang Zhao, and Yangxuan Liao
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HighlightsSoil rheological properties in the liquid phase under various clay contents, moisture contents, and settling times were investigated.A numerical model of the initial apparent viscosity was established and verified.The change in soil rheological behavior at different rotating speeds was analyzed.Abstract. It is particularly important to study the rheological properties and rheological behavior of liquid-phase paddy soil to improve the working efficiency of power machinery in paddy fields. In this research, a rotational rheometer was used to record the shear stress, shear rate, and apparent viscosity of the soil during the test. Additionally, a numerical model was established to explore the effects of soil clay content, moisture content, and settling time on soil rheological properties. Through single factor analysis, the contribution rate of each factor to the change in the initial apparent soil viscosity was ranked as follows: moisture content (X2) > soil clay content (X1) > settling time (X3). Subsequently, the variations in shear stress and apparent viscosity at different shear rates were explored. The changing trend of soil rheological behavior was mainly related to soil texture, in which silty loam was thixotropic and clay loam was gelatinous. The prediction models for the initial apparent viscosity were validated, and the results showed great agreement. The research evaluated and predicted the rheological behavior of liquid-phase paddy field soil and provides a reference for the design, development, and use of paddy field power machinery. Keywords: Apparent viscosity, Clay content, Moisture content, Rheology, Settling time, Shear stress.
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- 2022
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6. THE EFFECTS OF MULTIPLE PARAMETERS ON INITIAL APPARENT VISCOSITY AND RHEOLOGICAL BEHAVIOR IN A LIQUID-PHASE PADDY FIELD.
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Lunqing Sun, Yuxuan Pan, Yongwei Wang, Keling Xiao, Yiyang Zhao, and Yangxuan Liao
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VISCOSITY ,RHEOLOGY ,CLAY soils ,SHEARING force ,SOIL texture ,PADDY fields - Abstract
It is particularly important to study the rheological properties and rheological behavior of liquid-phase paddy soil to improve the working efficiency of power machinery in paddy fields. In this research, a rotational rheometer was used to record the shear stress, shear rate, and apparent viscosity of the soil during the test. Additionally, a numerical model was established to explore the effects of soil clay content, moisture content, and settling time on soil rheological properties. Through single factor analysis, the contribution rate of each factor to the change in the initial apparent soil viscosity was ranked as follows: moisture content (X2) > soil clay content (X1) > settling time (X3). Subsequently, the variations in shear stress and apparent viscosity at different shear rates were explored. The changing trend of soil rheological behavior was mainly related to soil texture, in which silty loam was thixotropic and clay loam was gelatinous. The prediction models for the initial apparent viscosity were validated, and the results showed great agreement. The research evaluated and predicted the rheological behavior of liquid-phase paddy field soil and provides a reference for the design, development, and use of paddy field power machinery. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Association of vascular endothelial function and quality of life in patients with ischemia and non-obstructive coronary artery disease
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Keling Xiao, Machao Liu, Xipeng Sun, Yinghua Zhang, Jin Si, Ning Shi, Lijie Sun, Zupei Miao, Haoyu Zhang, Ting Zhao, Zhi Liu, Zhenxing Fan, Jing Gao, and Jing Li
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Cardiology and Cardiovascular Medicine - Abstract
Improvements are required in the quality of life (QoL) of patients with ischemia and non-obstructive coronary artery disease (INOCA). Several patients with INOCA experience vascular endothelial dysfunction. However, the relationship between endothelial function and QoL remains unelucidated. This study aimed to initially investigate the relationship between endothelial function and QoL in patients with INOCA. This prospective observational study included 121 patients with INOCA (aged 31-85 years). Vascular endothelial function was assessed by flow-mediated dilatation (FMD) of the peripheral brachial artery. QoL was evaluated using the 36-Item Short-Form Health Survey (SF-36). Patients with INOCA were divided into two groups according to the median FMD change during the 1-year follow-up (group A, ≥ median FMD change cut-off; group B, median FMD change cut-off). The median change in FMD was 0.92%. The mean baseline SF-36 scores were comparable between the two groups (53.95 ± 6.46 vs. 53.92 ± 4.29, p = 0.98). The QoL at follow-up was better in group A than in group B (56.61 ± 5.50 vs. 53.32 ± 5.58, p = 0.002). The change in FMD (r = 0.34, p 0.01), rather than FMD at baseline (r = - 0.01, p = 0.89) or follow-up (r = 0.13, p = 0.15), was related to the follow-up SF-36 scores. FMD improvement was an independent predictor of increased QoL (odds ratio, 3.90; 95% confidence interval: 1.59-9.53, p = 0.003). Endothelial function change is associated with QoL, and patients with improved endothelial function have a better QoL than those without.
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- 2022
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