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Evolution aids theodicy, seen not as a process of random errors, but of probabilistic emergence. The cosmos is emergent, creative, self-realizing, and productive of the intrinsic values of knowledge, beauty and love. God is the demand, power and promise of love in such an emergent universe disfigured by greed (the corruption of creative self-realization), yet destined for loving communion.

In this article, we contribute to current debates on the role of partisan cues and political sophistication in explaining vaccine hesitancy by drawing on surveys conducted in France. We test whether partisan differences in attitudes to vaccines are best explained by partisan cues or by parties’ differences in propensity to attract people who distrust the actors involved in vaccination policies. We find a small effect of partisan cues and a much stronger effect of trust. But more importantly, we show that the more politically sophisticated are less vaccine hesitant and that the non-partisan are the biggest and most vaccine-hesitant group. To expose the implications of these results, we draw on the sociology of symbolic boundaries and the sociology of disenchantment with politics. We argue that the more politically sophisticated are more likely to be made aware of when politicians cross the lines of acceptable political debate.

Supplementary Figure 2: In vivo imaging of RTA 408-treated xenografts of human prostate cancer cells constitutively expressing firefly luciferase. Representative images of mice bearing PC3, DU145, LNCaP/C4-2B and CWR22Rv1 xenografts treated with either vehicle or RTA 408 were acquired prior to treatment (day 0) and during treatment at the time points indicated.

Supplementary Figure 4: Effects of RTA 408 on radiation sensitivity of prostate cancer cell lines as determined by clonogenic survival assays. Cells were treated at 24 and 1 h with RTA 408 prior to IR exposure as indicated. Differences between curves were analyzed by two-way ANOVA, designating drug treatment and IR as variables. P value summaries of pair-wise comparisons between drug and vehicle treatment curves are shown.

Supplemental Figure 5: Effects of RTA 408 on morphological appearance of normal prostate epithelial cells (PrEC), normal human keratinocytes (NHEK-1) and PC3 cells (scale bars 100 μM). RTA 408 was added to cultures for 72 h at the concentrations indicated.

Supplementary Figure 1: Reduction in apoptosis incidence in the skin of irradiated mice. Topical radiation (30 Gy single dose) was applied to the hindlegs of mice with shielding protecting the rest of the body. RTA 408 (17.5 mg/kg) was administered 1 d prior, 1 h prior and 1 d post IR; skins were harvested 2 d post IR. Apoptotic cells were detected by TUNEL staining in tissue samples obtained 24 h after radiation exposure. The number of apoptotic cells in RTA 408-treated mice was statistically significantly reduced compared to IR + vehicle-treated mice (Student's t-test; p

Supplementary Figure 3: Effects of RTA 408 on prostate cancer cell survival in vitro. Cells were treated for 24 h with RTA 408 at different concentrations. Protein extracts were prepared from attached and/or detached cells to capture the full extent of apoptosis. Protein extracts from detached cells were prepared at RTA 408 concentrations {greater than or equal to}0.5 μM; solid lines above protein concentrations indicate detached cells as a source of proteins. Levels of cleaved caspase 3, cleaved PARP-1, cleaved cytokeratin-18 (M30) and cleaved caspase-8 were determined by immunoblot analyses.

List of Supplementary Figures

In the past ten years, increasing attention has been paid to the influence of political identities on attitudes towards vaccines. To explain partisan differences in attitudes to vaccines, researchers have tended to focus on a “top-down” approach combining partisan cues and motivated reasoning. In this paper, we study the evolution of intentions to vaccinate against COVID-19 over time by drawing on 34 cross-sectional surveys covering a period of approximately a year and a half (March 2020-June 2021, n=38 416). Across the whole period, people who felt closest to parties on the Far Right, the Far Left and those who felt closest to no party at all were more likely to not intend to vaccinate than people who felt closest to parties on the Left, the Right and at the Center. To explain partisan differences in attitudes to vaccines, researchers have focused on a “top-down” approach combining partisan cues and motivated reasoning. We show that this approach can explain only very partly these results and that it does not pay sufficient attention to disengagement with politics. We conclude by advocating for a better articulation between work on cognitive mechanisms and work on the strategies deployed by partisan organisations to gain followers.

Integrated care, an approach designed to improve health/ behavioral health outcomes and increase quality of life, has received international interest. Given the important roles social workers play ...

My argument is that naturalism is too restricted and dogmatic an account of the many different sorts of entities and explanations that we employ in trying to understand our world. It is a faith rather than a mode of inquiry.

Rowan Williams argues that the Incarnation sponsors a distinctive metaphysical view of God and the world. I agree, but query his basically Thomist account of the Incarnation. For Aquinas, essences are more real than particulars, causes must be like and greater than their effects, and the first cause must be a supreme essence without potentiality or change. But it may be that essences are merely possible states, and causes must have powers (potencies) to act. Therefore God, conceiving all possible states and having all possible powers, does contain potentials. One of these powers is the power to act as a particular causal agent in the world, which Dr Williams denies. I suggest that the Incarnation entails a particular causal divine act that adds something essential to the eternal Word, by changing the nature of the divine love, and realizing its potential as agape, love given to the truly other and imperfect.