32 results on '"Keith JF"'
Search Results
2. Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birth weight preterm infants.
- Author
-
Shannon KM, Keith JF 3rd, Mentzer WC, Ehrenkranz RA, Brown MS, Widness JA, Gleason CA, Bifano EM, Millard DD, and Davis CB
- Abstract
DESIGN AND METHODS. We hypothesized that treatment with recombinant human erythropoietin (r-HuEPO) would stimulate erythropoiesis and would thereby reduce the need for erythrocyte transfusions in preterm infants. We treated 157 preterm infants born at 26.9 +/- 1.6 weeks of gestation who weighed 924 +/- 183 g at birth with either subcutaneous r-HuEPO (100 U/kg/d, 5 days per week) or placebo for 6 weeks in a randomized, double-blind, controlled clinical trial. All patients received oral iron and were managed according to uniform conservative transfusion guidelines. RESULTS. Treatment with r-HuEPO was associated with fewer erythrocyte transfusions (1.1 +/- 1.5 per infant in the r-HuEPO group versus 1.6 +/- 1.7 per infant in the placebo group; P = .046) and with a reduction in the volume of packed erythrocytes transfused (16.5 +/- 23.0 mL versus 23.9 +/- 25.7 mL per infant; P = .023). Overall, 43% of the infants in the r-HuEPO group and 31% of placebo-treated infants were transfusion-free during the study (P = .18). The volume of blood removed for laboratory tests and the need for respiratory support at the start of treatment had major effects on transfusion requirements independent of r-HuEPO. Reticulocyte counts were higher during treatment in the r-HuEPO group (P = .0001), and r-HuEPO-treated infants had higher hematocrit values at the end of the study (32% versus 27.3% in the placebo group; P = .0001). We found no differences in the incidence of major complications of prematurity between the treatment groups. CONCLUSION. We conclude that treatment with r-HuEPO at a weekly dose of 500 U/kg stimulates erythropoiesis, moderates the course of anemia, is associated with a reduction in erythrocyte transfusions, and appears safe in very low birth weight preterm infants who are receiving iron supplements. Conservative transfusion criteria, minimization of phlebotomy losses, and treatment with r-HuEPO are complementary strategies to reduce erythrocyte transfusions in these infants. [ABSTRACT FROM AUTHOR]
- Published
- 1995
- Full Text
- View/download PDF
3. A Report on the Complete Abandonment of the Operation for Removing Entire Calculi from the Bladder; and the Methods Employed Instead at the Civil Hospital, Hyderabad, Sindh
- Author
-
Keith Jf
- Subjects
Computer science ,Abandonment (legal) ,General Engineering ,General Earth and Planetary Sciences ,Operations management ,Articles ,General Medicine ,Data science ,General Environmental Science - Published
- 1892
4. Cardiomyopathy Associated With Tricyclic Antidepressants
- Author
-
Poe Te, Keith Jf, and Howland Js
- Subjects
Cardiomyopathy, Dilated ,Heart Failure ,Male ,chemistry.chemical_classification ,Cardiac Catheterization ,medicine.medical_specialty ,business.industry ,Cardiomyopathy ,Pulmonary Edema ,General Medicine ,Antidepressive Agents, Tricyclic ,Middle Aged ,medicine.disease ,chemistry ,Internal medicine ,Ventricular fibrillation ,Cardiology ,medicine ,Animals ,Humans ,Female ,In patient ,business ,Tricyclic - Abstract
Nine other cases of cardiomyopathy in patients taking tricyclic antidepressants have been reported. The patient we have described had been taking tricyclic antidepressants for years before cardiomyopathy developed. While a cause-and-effect relationship between tricyclic antidepressants and cardiomyopathy cannot be proven, physicians should keep in mind the association and discontinue the medication if cardiomyopathy develops. Further, tricyclic antidepressants should be used with great caution in patients with cardiomyopathy because of possible risk of ventricular fibrillation.
- Published
- 1983
5. Nitric oxide and bleeding time.
- Author
-
Gaston B and Keith JF 3rd
- Published
- 1994
- Full Text
- View/download PDF
6. The Effects of a Western Diet vs. a High-Fiber Unprocessed Diet on Health Outcomes in Mice Offspring.
- Author
-
Herzl E, Schmitt EE, Shearrer G, and Keith JF
- Subjects
- Pregnancy, Female, Mice, Animals, Humans, Blood Glucose metabolism, Glycated Hemoglobin, Mice, Inbred C57BL, Body Weight, Diet, Outcome Assessment, Health Care, Diet, High-Fat, Maternal Nutritional Physiological Phenomena, Diet, Western adverse effects, Prenatal Exposure Delayed Effects metabolism
- Abstract
Diet influences critical periods of growth, including gestation and early development. We hypothesized that a maternal/early life diet reflecting unprocessed dietary components would positively affect offspring metabolic and anthropometric parameters. Using 9 C57BL-6 dams, we simulated exposure to a Western diet, a high-fiber unprocessed diet (HFUD), or a control diet. The dams consumed their respective diets (Western [ n = 3], HFUD [ n = 3], and control [ n = 3]) through 3 weeks of pregnancy and 3 weeks of weaning; their offspring consumed the diet of their mother for 4.5 weeks post weaning. Measurements included dual X-ray absorptiometry (DEXA) scans, feed consumption, body weight, blood glucose, and insulin and glycated hemoglobin (HbA1c) in the offspring. Statistical analyses included one-way ANOVA with Tukey's post hoc analysis. The offspring DEXA measures at 5 and 7.5 weeks post parturition revealed higher lean body mass development in the HFUD and control diet offspring compared to the Western diet offspring. An analysis indicated that blood glucose ( p = 0.001) and HbA1c concentrations ( p = 0.002) were lower among the HFUD offspring compared to the Western and control offspring. The results demonstrate that diet during gestation and early life consistent with traditional diet patterns may influence hyperglycemia and adiposity in offspring.
- Published
- 2023
- Full Text
- View/download PDF
7. Service, Scholarship, and Sacrifice: A Qualitative Analysis of Food Security Barriers and Strategies among Military-Connected Students.
- Author
-
Schinkel KR, Budowle R, Porter CM, Dai B, Gifford C, and Keith JF
- Subjects
- Humans, United States, Cross-Sectional Studies, Socioeconomic Factors, Students, Universities, Food Security, Fellowships and Scholarships, Food Supply
- Abstract
Background: In the United States, 41% of 4-year university student veterans have reported food insecurity, but literature on food insecurity among military-connected students is limited., Objective: The objective of the study was to increase knowledge of military-connected student food insecurity experiences and potential strategies to address food access., Design: The study is a cross-sectional survey and nonexperimental qualitative cohort analysis., Participants and Setting: Military-connected students (n = 127) responded to a survey sampling all enrolled students at a Mountain West land grant university during spring 2020. Military-connected student focus group participants (n = 8) were purposively sampled from the same university during fall 2020., Main Outcome Measures: Main outcome measures were demographic data and food insecurity rates. Qualitative measures included responses to questions about food insecurity among military-connected students, actions for improving food insecurity, and insight into food access resources on campus., Statistical Analysis: Descriptive statistics were used to determine food insecurity rates. Qualitative analysis included audio recording and transcription, then a step-by-step process for coding and theme development., Results: Food insecurity was reported by 42.5% of military-connected student survey respondents. Qualitative analysis revealed themes about current and planned food access resources, barriers to food security, and strategies to promote military-connected student food security. Main themes related to resources were access to resources and food offerings. Main barrier themes were pride and shame. Main strategy themes included military pride and military connections and culture., Conclusions: Military-connected students are at least as vulnerable to food insecurity as the student body at large. Qualitative analysis identified barriers and strategies for food security among military-connected students. Feelings of pride in identifying with the military seemed to amplify feelings of shame about food insecurity; however, this pride and sense of military community also suggest that food security efforts specifically tailored to military-connected students could be successful., (Copyright © 2023 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
8. Eating Disorder Examination-Questionnaire and Clinical Impairment Assessment norms for intersectional identities using an MTurk sample.
- Author
-
Kambanis PE, Bottera AR, Mancuso CJ, Spoor SP, Anderson LM, Burke NL, Eddy KT, Forbush KT, Keith JF, Lavender JM, Mensinger JL, Mujica C, Nagata JM, Perez M, and De Young KP
- Subjects
- Infant, Newborn, Humans, Female, Male, Feeding and Eating Disorders diagnosis
- Abstract
Objective: There are limited data to guide the interpretation of scores on measures of eating-disorder psychopathology among underrepresented individuals. We aimed to provide norms for the Eating Disorder Examination-Questionnaire (EDE-Q) and Clinical Impairment Assessment (CIA) across racial/ethnic, gender, and sexual identities, and sexual orientations and their intersections by recruiting a diverse sample of Amazon MTurk workers (MTurkers; N = 1782)., Method: We created a comprehensive, quantitative assessment of racial/ethnic identification, gender identification, sex assigned at birth, current sexual identification, and sexual orientation called the Demographic Assessment of Racial, Sexual, and Gender Identities (DARSGI). We calculated normative data for each demographic category response option., Results: Our sample was comprised of 68% underrepresented racial/ethnic identities, 42% underrepresented gender identities, 13% underrepresented sexes, and 49% underrepresented sexual orientations. We reported means and standard deviations for each demographic category response option and, where possible, mean estimates by percentile across intersectional groups. EDE-Q Global Score for a subset of identities and intersections in the current study were higher than previously reported norms for those identities/intersections., Discussion: This is the most thorough reporting of norms for the EDE-Q and CIA among racial/ethnic, sexual, and gender identities, and sexual orientations and the first reporting on multiple intersections, filling some of the gaps for commonly used measures of eating-disorder psychopathology. These norms may be used to contextualize eating-disorder psychopathology reported by underrepresented individuals. The data from the current study may help inform research on the prevention and treatment of eating-disorder psychopathology in underrepresented groups., Public Significance: We provide the most thorough reporting on racial/ethnic, sexual, and gender identities, and sexual orientations for the Eating Disorder Examination - Questionnaire and Clinical Impairment Assessment, and the first reporting on intersections, which fills some of the gaps for commonly used measures of eating-disorder psychopathology. These norms help inform research on the prevention and treatment of eating-disorder psychopathology in underrepresented groups., (© 2022 Wiley Periodicals LLC.)
- Published
- 2022
- Full Text
- View/download PDF
9. Nutrient and popping characteristics of Wyoming-grown Peruvian popping beans.
- Author
-
Bolak J, Gifford C, Rule D, Heitholt J, and Keith JF
- Abstract
American consumers fall short of dietary fiber intake recommended by dietary guidelines. Beans provide protein and fiber, however, less than 14% of adults include them in their daily diets. Nuña beans ( Phaseolus vulgaris L.), a class of common beans originated in South America and cultivated for growth in North America, possess a unique set of characteristics including flavor profile, popping ability, and nutrient content that may appeal to consumers. The purpose of this study was to evaluate a unique line of Wyoming-grown popping beans to (1) determine nutrient characteristics and (2) assess popping percentage and shelf stability. Crude protein content was determined for five lines grown in Wyoming utilizing the Dumas method for nitrogen quantification. Total fatty acid content and a fatty acid profile for one line (CO49957) was determined by gas-liquid chromatography. Popping percentage was assessed by heating beans in canola oil in a cast iron pan to induce popping. Storage duration impact on popping was evaluated on CO49957 at 6, 12, and 15 months after harvest. Crude protein content was significantly different between all five lines. Total fatty acid content of CO49957 averaged 2.90 g/100 g wet weight. Average fatty acid profile of CO49957 popped in canola oil comprised oleic acid (41.4%), linoleic acid (20.4%), α-linolenic acid (18.6%), palmitic acid (10.4%), and stearic acid (2.23%). Popping percentage was 90% (baseline), 100% (6 months), 87% (12 months), and 80% (15 months). Popping beans provide plant-based protein and fiber while maintaining adequate levels of popping percentage with prolonged storage., Competing Interests: The authors declare that they do not have any conflict of interest., (© 2022 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.)
- Published
- 2022
- Full Text
- View/download PDF
10. Enacting Treaty Rights through Restoring Shoshone Ancestral Foods on the Wind River Indian Reservation.
- Author
-
Shoshone AL, Keith JF, Olsen L, Barney N, Clark C, LeBeau JL, Meyers D, Mills C, Mionczynski J, Panzetanga V, and Wechsler A
- Abstract
Despite great loss in gathering and consumption of traditional foods among Indigenous communities, there is great hope for reclaiming and preserving knowledge. The Restoring Shoshone Ancestral Food Gathering (RSAFG) is a community group leading grassroots efforts on the Wind River reservation to reclaim Shoshone ancestral foods and promote food sovereignty. The story of the RSAFG promotes equitable, decolonized, and community empowered methods of reclaiming Indigenous foods by sharing three of RSAFG's acts of decolonization: 1) enacting treaty rights through gathering traditional plants, 2) demanding equitable partnerships in community-based research, and 3) sharing the story through radical authorship via layered narratives. A pesar de la gran pérdida en la recolección y el consumo de alimentos tradicionales entre las comunidades indígenas, existe una gran esperanza para recuperar y preservar el conocimiento. El Restoring Shoshone Ancestral Food Gathering (RSAFG) es un grupo comunitario que lidera los esfuerzos de base en la reserva wind river para recuperar los alimentos ancestrales shoshone y promover la soberanía alimentaria. La historia de la RSAFG promueve métodos equitativos, descolonizados y empoderados por la comunidad para recuperar los alimentos indígenas al compartir tres de los actos de descolonización de RSAFG: 1) promulgar los derechos de los tratados mediante la recolección de plantas tradicionales, 2) exigir asociaciones equitativas en la investigación basada en la comunidad, y 3) compartir la historia a través de la autoría radical a través de narrativas en capas.
- Published
- 2022
- Full Text
- View/download PDF
11. Measures Derived from Panoramic Ultrasonography and Animal-Based Protein Intake Are Related to Muscular Performance in Middle-Aged Adults.
- Author
-
Johnson NR, Kotarsky CJ, Hackney KJ, Trautman KA, Dicks ND, Byun W, Keith JF, David SL, and Stastny SN
- Abstract
Ultrasonography advantageously measures skeletal muscle size and quality, but some muscles may be too large to capture with standardized brightness mode (B-mode) imaging. Panoramic ultrasonography can capture more complete images and may more accurately measure muscle size. We investigated measurements made using panoramic compared to B-mode ultrasonography images of the rectus femoris with muscular performance. Concurrently, protein intake plays an important role in preventing sarcopenia; therefore, we also sought to investigate the association between animal-based protein intake (ABPI) and muscular performance. Ninety-one middle-aged adults were recruited. Muscle cross-sectional area (CSA) and thickness were obtained using B-mode and panoramic ultrasound and analyzed with Image J software. Muscular performance was assessed using isokinetic dynamometry, a 30-s chair test, and handgrip strength. Three-day food diaries estimated dietary intakes. Linear regression models determined relationships between measures from ultrasonography and muscular performance. Mixed linear models were used to evaluate the association between ABPI and muscular performance. Muscle CSA from panoramic ultrasonography and ABPI were positively associated with lower-body strength (β ± S.E.; CSA, 42.622 ± 20.024, p = 0.005; ABPI, 65.874 ± 19.855, p = 0.001), lower-body endurance (β ± S.E.; CSA, 595 ± 200.221, p = 0.001; ABPI, 549.944 ± 232.478, p = 0.020), and handgrip strength (β ± S.E.; CSA, 6.966 ± 3.328, p = 0.004; ABPI, 0.349 ± 0.171, p = 0.045). Panoramic ultrasound shows promise as a method for assessing sarcopenia. ABPI is related to better muscular performance.
- Published
- 2021
- Full Text
- View/download PDF
12. Vitamin D Synthesis Following a Single Bout of Sun Exposure in Older and Younger Men and Women.
- Author
-
Chalcraft JR, Cardinal LM, Wechsler PJ, Hollis BW, Gerow KG, Alexander BM, Keith JF, and Larson-Meyer DE
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Regression Analysis, Skin metabolism, Time Factors, Vitamin D blood, Vitamin D Deficiency etiology, Young Adult, Age Factors, Cholecalciferol blood, Sunlight, Vitamin D analogs & derivatives, Vitamin D biosynthesis
- Abstract
Older adults are frequently cited as an at-risk population for vitamin D deficiency that may in part be due to decreased cutaneous synthesis, a potentially important source of cholecalciferol (vitamin D
3 ). Previous studies found that cutaneous D3 production declines with age; however, most studies have been conducted ex vivo or in the photobiology lab. The purpose of this study was to characterize the response of vitamin D metabolites following a 30-min bout of sun exposure (15-min each to the dorsal and ventral sides) at close to solar noon in younger and older adults., Methods: 30 healthy individuals with skin type II/III were recruited; a younger cohort, aged 20-37 ( n = 18) and an older cohort ( n = 12), age 51-69 years. Exposure was at outer limits of sensible sun exposure designed to enhance vitamin D synthesis without increasing risk of photo ageing and non-melanoma skin cancer. Serum D3 concentration was measured at baseline, 24, 48 and 72 h post-exposure. Serum 25(OH)D was measured at baseline and 72 h post-exposure plus 168 h post-exposure in the older cohort., Results: D3 increased in response to sun exposure (time effect; p = 0.002) with a trend for a difference in D3 between cohorts (time*group; p = 0.09). By regression modeling of continuous data, age accounted for 20% of the variation in D3 production. D3 production decreased by 13% per decade. Despite changes in D3 , however, serum 25(OH)D did not change from baseline to 72 or 168 h post exposure ( p > 0.10)., Conclusions: Serum D3 concentration increased significantly in response to outdoor sun exposure in younger and older adults. While ageing may dampen cutaneous synthesis, sunlight exposure is still a significant source of vitamin D3 .- Published
- 2020
- Full Text
- View/download PDF
13. Contribution of Protein Intake and Concurrent Exercise to Skeletal Muscle Quality with Aging.
- Author
-
Dicks ND, Kotarsky CJ, Trautman KA, Barry AM, Keith JF, Mitchell S, Byun W, Stastny SN, and Hackney KJ
- Subjects
- Adult, Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Young Adult, Aging physiology, Dietary Proteins administration & dosage, Exercise physiology, Muscle, Skeletal physiology
- Abstract
Background: The use of magnetic resonance imaging (MRI) derived functional cross-sectional area (FCSA) and intramuscular adipose tissue (IMAT) to define skeletal muscle quality is of fundamental importance in order to understand aging and inactivity-related loss of muscle mass., Objectives: This study examined factors associated with lower-extremity skeletal muscle quality in healthy, younger, and middle-aged adults., Design: Cross-sectional study., Setting and Participants: Ninety-eight participants (53% female) were classified as younger (20-35 years, n=50) or middle-aged (50-65 years, n=48) as well as sedentary (≤1 day per week) or active (≥3 days per week) on self-reported concurrent exercise (aerobic and resistance)., Measurements: All participants wore an accelerometer for seven days, recorded a three-day food diary, and participated in magnetic resonance imaging (MRI) of the lower limbs. Muscle cross-sectional area (CSA) was determined by tracing the knee extensors (KE) and plantar flexors, while muscle quality was established through the determination of FCSA and IMAT via color thresholding., Results: One-way analysis of variance and stepwise regression models were performed to predict FCSA and IMAT. KE-IMAT (cm2) was significantly higher among sedentary (3.74 ± 1.93) vs. active (1.85 ± 0.56) and middle-aged (3.14 ± 2.05) vs. younger (2.74 ± 1.25) (p < 0.05). Protein intake (g•kg•day-1) was significantly higher in active (1.63 ± 0.55) vs. sedentary (1.19 ± 0.40) (p < 0.05). Sex, age, concurrent exercise training status, and protein intake were significant predictors of KE FCSA (R2 = 0.71, p < 0.01), while concurrent exercise training status and light physical activity predicted 33% of the variance in KE IMAT (p < 0.01)., Conclusion: Concurrent exercise training, dietary protein intake, and light physical activity are significant determinants of skeletal muscle health and require further investigation to mitigate aging and inactivity-related loss of muscle quality., Competing Interests: There are no conflicts of interest.
- Published
- 2020
- Full Text
- View/download PDF
14. Barriers and Strategies for Healthy Food Choices among American Indian Tribal College Students: A Qualitative Analysis.
- Author
-
Keith JF, Stastny S, Brunt A, and Agnew W
- Subjects
- Adult, Female, Food Preferences ethnology, Humans, Male, Qualitative Research, Self Efficacy, Universities, Young Adult, Alaska Natives psychology, Food Preferences psychology, Health Behavior ethnology, Indians, North American psychology, Students psychology
- Abstract
Background: American Indian and Alaskan Native individuals experience disproportionate levels of chronic health conditions such as type 2 diabetes and overweight and obesity that are influenced by dietary patterns and food choices. Understanding factors that influence healthy food choices among tribal college students can enrich education and programs that target dietary intake., Objective: To build an understanding of factors that influence healthy food choices among tribal college students at increased risk for college attrition., Design: A nonexperimental cohort design was used for qualitative descriptive analysis., Participants/setting: Participants (N=20) were purposively sampled, newly enrolled, academically underprepared tribal college students enrolled in a culturally relevant life skills course at an upper Midwest tribal college between September 2013 and May 2015. Participant demographic characteristics included various tribal affiliations, ages, and number of dependents., Main Outcome Measures: Participant responses to qualitative research questions about dietary intake, food choices, self-efficacy for healthy food choices, psychosocial determinants, and barriers to healthy food choices during telephone interviews were used as measures., Analysis: Qualitative analysis included prestudy identification of researcher bias/assumptions, audiorecording and transcription, initial analysis (coding), secondary analysis (sorting and identifying meaning), and verification (comparative pattern analysis)., Results: Qualitative analysis revealed a variety of themes and subthemes about healthy food choices. Main themes related to barriers included taste, food gathering and preparation, and difficulty clarifying healthy food choices. Main themes related to strategies included taste, cultural traditions and practices, and personal motivation factors., Conclusions: Qualitative analysis identified barrier and strategy themes that may assist nutrition and dietetics practitioners working with tribal/indigenous communities, tribal college educators and health specialists, and tribal community health workers who target health and dietary intake of American Indian and Alaskan Native students., (Copyright © 2018 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
15. Comparison between two and five doses a week of recombinant human erythropoietin for anemia of prematurity: a randomized trial.
- Author
-
Brown MS and Keith JF 3rd
- Subjects
- Dose-Response Relationship, Drug, Female, Ferritins blood, Hematocrit, Humans, Infant, Newborn, Infant, Premature, Male, Recombinant Proteins, Reticulocyte Count, Treatment Outcome, Anemia drug therapy, Erythropoietin administration & dosage, Infant, Premature, Diseases drug therapy, Infant, Very Low Birth Weight
- Abstract
Objective: To compare the erythropoietic response between two and five times a week dosages of recombinant human erythropoietin (r-EPO) using the same weekly dose, 500 U/kg, in very low birth weight (VLBW) infants., Study Design: Eighty VLBW infants were stratified into two gestational age groups and randomized to receive 500 U/kg of r-EPO either two or five times a week; 72 infants completed at least 4 weeks of study. The primary outcome variable was absolute reticulocyte counts at 4 weeks. Secondary outcome variables were hematocrits, transfusions, iatrogenic blood losses, infections, and serum ferritins. Multiple regression analysis was used to evaluate the secondary outcome variables., Results: By 4 weeks, absolute reticulocyte counts were higher in the infants given r-EPO five times a week [mean (SEM)]: 173 000/mm(3) (15 000) vs 220 000/mm(3) (18 000), two versus five doses per week, respectively. Hematocrits, 34.9% (0.9) vs 34.1% (0.8), and transfusions per infant, 2.06 (0.4) vs 2.11 (0.4), were not different between the groups. Additionally, 79% of the variance in the amount of blood transfused was accounted for by iatrogenic blood loss, the latter primarily associated with number of days ventilated. Episodes of sepsis and necrotizing enterocolitis were significantly associated with decreased absolute reticulocyte counts and increased transfusions., Conclusions: More frequent dosing of the same weekly amount of r-EPO produced a significant and sustained increase in stimulated erythropoiesis in VLBW infants. The importance of this finding on reducing transfusions was not able to be demonstrated because this study was not intended to differentiate transfusions. In this population of infants and at the dose level of r-EPO, iatrogenic blood loss contributed more to transfusions than a lower level of erythropoiesis, the former primarily associated with mechanical ventilation. Based on this and other studies, when VLBW infants are at risk for greater phlebotomy losses, it may be justifiable to use more vigorous r-EPO treatment, and when at lower risk to use less frequent dosing to enhance cost-effectiveness.
- Published
- 1999
- Full Text
- View/download PDF
16. Into the next century. A strategic plan for the North Carolina Physicians Health Program.
- Author
-
Keith JF Jr
- Subjects
- Humans, North Carolina, Rehabilitation, United States, Physician Impairment, Program Development
- Abstract
The staff and Board of Directors of NCPHP have developed a strategic plan to carry the Program into the next century. The goals of the plan are: 1) to reduce the risk of impairment among medical health care professionals through the application of primary prevention principles, 2) to provide improved outreach/intervention strategies for impaired professionals, and 3) to provide state-of-the-art treatment/rehabilitation services for impaired professionals and their families. Of course, appropriate staffing and fiscal resources will be a critical part of this process.
- Published
- 1996
17. Sensitivity and specificity of rapid diagnostic tests for detection of group B streptococcal antigen in bacteremic neonates.
- Author
-
Greenberg DN, Ascher DP, Yoder BA, Hensley DM, Heiman HS, and Keith JF 3rd
- Subjects
- Bacteremia microbiology, Female, Humans, Infant, Newborn, Male, Prospective Studies, Reagent Kits, Diagnostic, Sensitivity and Specificity, Time Factors, Antigens, Bacterial urine, Immunoassay, Latex Fixation Tests, Streptococcal Infections diagnosis, Streptococcus agalactiae immunology
- Abstract
Latex particle agglutination (LPA) testing for antigen to group B streptococcus (GBS) has been useful in the diagnosis of GBS sepsis in newborns. However, recent reports have demonstrated that the sensitivity of LPA assays may be as low as 27 to 54%. The purposes of the present study were to directly compare the abilities of four urine antigen assays to detect GBS antigen with clinical urine samples from neonates with GBS bacteremia and to evaluate the effect of the urine concentration on the sensitivities and specificities of these assays. Urine samples were collected serially from neonates with blood cultures positive for GBS or on admission from healthy full-term infants. One milliliter of urine was removed, and the remainder was concentrated to a volume of 1 ml. Unconcentrated samples were serially diluted with normal saline and were assayed to determine the highest dilution which would produce a positive test result. The Wellcogen, Bactigen, and Directigen LPA tests and ICON immunoassay were directly compared by using concentrated and unconcentrated urine specimens and urine specimens with known titers. A total of 94 urine specimens, including 61 concentrated and 75 unconcentrated specimens, from bacteremic infants were available for sensitivity testing, and 220 urine specimens from uninfected infants were available for specificity testing. There were significant differences in sensitivity among the four assays when they were performed on concentrated urine specimens, as follows: Directigen, 98%; Bactigen, 92%; ICON, 89%; Wellcogen, 68%. When the assays were performed on unconcentrated urine specimens, the Directigen (84%) and Bactigen (76%) assays were each significantly more sensitive than the ICON (59%) or Wellcogen (43%) assay. All four assays were significantly more sensitive in detecting GBS antigen in concentrated than in unconcentrated urine. The Directigen assay detected antigen in higher dilutions (geometric mean titer, 1:5) than the ICON (1:3), Bactigen (1.2), or Wellcogen (1:1) assay. The specificity was 99.5% for all four assays when concentrated urine was used and for the Bactigen, Directigen, and ICON assays when unconcentrated urine was used; the Wellcogen assay was 100% specific when unconcentrated urine was used. We conclude that there are significant differences in sensitivity but not specificity among the commercially available assays for the detection of GBS antigenuria when concentrated and unconcentrated urine specimens are tested. These differences in sensitivity may affect the abilities of clinicians to accurately diagnose GBS sepsis before culture results are available.
- Published
- 1995
- Full Text
- View/download PDF
18. Group B streptococcus serotype V.
- Author
-
Greenberg DN, Ascher DP, Yoder BA, Heiman HS, and Keith JF 3rd
- Subjects
- Humans, Infant, Newborn, Serotyping, Streptococcal Infections microbiology, Streptococcus agalactiae classification
- Published
- 1993
- Full Text
- View/download PDF
19. Drug interactions with furosemide.
- Author
-
Poe TE, Scott RB, and Keith JF Jr
- Subjects
- Drug Interactions, Humans, Diflunisal pharmacology, Furosemide antagonists & inhibitors, Indomethacin pharmacology, Salicylates pharmacology
- Published
- 1984
20. Principles and practices of screening for disease.
- Author
-
Dembert ML, Brownstein AH, and Keith JF 3rd
- Subjects
- Health Planning, Humans, Mass Screening standards, Military Medicine, Multiphasic Screening methods, Philosophy, Medical, United States, Mass Screening methods
- Published
- 1988
21. Interaction of indomethacin with furosemide.
- Author
-
Poe TE, Scott RB, and Keith JF Jr
- Subjects
- Aged, Arthritis drug therapy, Drug Interactions, Female, Gout drug therapy, Heart Failure complications, Humans, Furosemide adverse effects, Indomethacin adverse effects, Water-Electrolyte Imbalance chemically induced
- Published
- 1983
22. Extending the extenders. Compromise for the geriatric specialization-manpower debate.
- Author
-
Romeis JC, Schey HM, Marion GS, and Keith JF Jr
- Subjects
- Aged, Community Health Centers statistics & numerical data, Consumer Behavior, Curriculum, Education, Medical, Graduate, Family Practice, Female, Hospitalization, Humans, Male, United States, Workforce, Geriatrics education, Health Services for the Aged, Physician Assistants statistics & numerical data
- Abstract
This pilot study reports on issues germane to the geriatric specialization-manpower debate. The study found that a large amount of the functional responsibility required by older adults in an urban clinic setting could be delegated to physician extenders. Other findings included shorter hospitalizations, increased feelings of well-being, and high patient satisfaction with physician extended care. The implications are that rather than develop a new physician specialty, more geriatric manpower needs could be met by delegating responsibility to appropriately trained and supervised physician extenders.
- Published
- 1985
- Full Text
- View/download PDF
23. Family practice building, Bowman Gray School of Medicine.
- Author
-
Keith JF and Edsel WM
- Subjects
- North Carolina, Academic Medical Centers organization & administration, Facility Design and Construction, Family Practice education, Health Facilities, Medical Office Buildings
- Published
- 1979
24. Family practice: quality and credibility.
- Author
-
Keith JF
- Subjects
- Family Practice standards, Quality of Health Care, United States, Family Practice trends
- Published
- 1977
- Full Text
- View/download PDF
25. Medical advice for foreign travel.
- Author
-
Dembert ML, Weinberg WG, Fraser JR, Baemmert RJ, Ledbetter EK, Keith JF 3rd, and Taylor WH
- Subjects
- Female, Humans, Male, Pregnancy, Immunization, Military Personnel, Preventive Medicine, Travel
- Published
- 1986
26. Cardiomyopathy associated with tricyclic antidepressants.
- Author
-
Howland JS, Poe TE, and Keith JF Jr
- Subjects
- Animals, Cardiac Catheterization, Female, Humans, Male, Middle Aged, Pulmonary Edema chemically induced, Antidepressive Agents, Tricyclic adverse effects, Cardiomyopathy, Dilated chemically induced, Heart Failure chemically induced
- Abstract
Nine other cases of cardiomyopathy in patients taking tricyclic antidepressants have been reported. The patient we have described had been taking tricyclic antidepressants for years before cardiomyopathy developed. While a cause-and-effect relationship between tricyclic antidepressants and cardiomyopathy cannot be proven, physicians should keep in mind the association and discontinue the medication if cardiomyopathy develops. Further, tricyclic antidepressants should be used with great caution in patients with cardiomyopathy because of possible risk of ventricular fibrillation.
- Published
- 1983
- Full Text
- View/download PDF
27. A model program for training residents in medical practice management.
- Author
-
Edsel WM, Duckett CH, and Keith JF
- Subjects
- Curriculum, North Carolina, Internship and Residency, Practice Management, Medical
- Abstract
The Department of Family and Community Medicine of the Bowman Gray School of Medicine has developed a seminar series to train physicians to effectively and efficiently manage their practices.
- Published
- 1978
28. Evaluating the potential pediatric scuba diver.
- Author
-
Dembert ML and Keith JF 3rd
- Subjects
- Adolescent, Age Factors, Barotrauma etiology, Child, Child, Preschool, Decompression Sickness etiology, Humans, Physical Examination, Diving adverse effects
- Published
- 1986
29. A practitioner's thoughts on our medicine. A challenge for local medical society leadership.
- Author
-
Keith JF
- Subjects
- Community Health Services, North Carolina, Leadership, Societies, Medical
- Published
- 1972
30. A chronology of two weeks' fallout shelter confinement.
- Author
-
Hammes JA, Ahearn TR, and Keith JF Jr
- Subjects
- Adolescent, Adult, Aged, Child, Female, Humans, Male, Middle Aged, Social Isolation, Adaptation, Psychological, Civil Defense, Group Processes, Nuclear Warfare
- Published
- 1965
- Full Text
- View/download PDF
31. Studies on acute and chronic toxicity of tetraethyl ammonium ion (etamon); methods of reviving dogs after a lethal dose.
- Author
-
KEITH JF Jr, GREEN HD, WILLIAMS SC, and DAVIS CC
- Subjects
- Animals, Dogs, Ammonium Compounds, Biological Products, Soybean Proteins, Tetraethylammonium toxicity
- Published
- 1952
- Full Text
- View/download PDF
32. Therapeutic misuse of salicylate compounds with resulting intoxications; a report of two cases in infancy.
- Author
-
KEITH JF Jr
- Subjects
- Child, Humans, Infant, North Carolina, Poisoning, Salicylates poisoning
- Published
- 1955
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.