Search

Background Transnasal endoscopy presents a technical difficulty when inserting the flexible endoscope. It is unclear whether a particular breathing method is useful for transnasal endoscopy. Therefore, we conducted a prospective randomized controlled trial to compare endoscopic operability and patient tolerance between patients assigned to nasal breathing or oral breathing groups. Methods 198 eligible patients were randomly assigned to undergo transnasal endoscopy with nasal breathing or with oral breathing. Endoscopists and patients answered questionnaires on the endoscopic operability and patient tolerance using a 100-mm visual analog scale ranging from 0 (non-existent) to 100 (most difficult/unbearable). The visibility of the upper-middle pharynx was recorded. Results Patient characteristics did not differ significantly between the groups. Nasal breathing showed a higher rate of good visibility of the upper-middle pharynx than oral breathing (91.9 % vs. 27.6 %; P Conclusions Nasal breathing is superior to oral breathing for those performing and undergoing transnasal endoscopy. Nasal breathing led to good visibility of the upper-middle pharynx, improved endoscopic operability, and better patient tolerance, and was safer owing to decreased pharyngeal bleeding.

New-type sulfolane gel electrolytes exhibited high battery performance owing to chemical and physical control of Li2Sn dissolution and diffusion properties.

Background: Granulocyte and monocyte adsorptive apheresis (GMA) with Adacolumn has been widely used as a remission induction therapy for patients with active ulcerative colitis (UC). However, an appropriate GMA treatment strategy related to concomitant medication in patients with active UC has not been established. Herein, we investigated the influence of concomitant medications in the remission induction of GMA in patients with active UC.Methods: This multicenter retrospective cohort study included patients with UC who underwent GMA in five independent institutions in Japan from January 2011 to July 2021. Clinical factors associated with clinical remission (CR) were analyzed statistically.Result: A total of 133 patients with active UC who underwent GMA were included. Seventy-four patients achieved a CR after GMA. The overall CR rate was 55.6%. The multivariable analysis revealed that concomitant medication with 5-aminosalicylic acid, Mayo endoscopic subscore (MES), and concomitant medication with immunosuppressors (IMs) remained as predictors of CR after GMA (p = 0.027, odds ratio [OR] 0.157; p = 0.017, OR 2.983; and p = 0.008, OR 3.361, respectively). In the subgroup analysis in patients with MES 2, concomitant medication with IMs was demonstrated as a significant negative factor of CR after GMA (p = 0.042, OR 2.823). Seventy-four patients who achieved CR after GMA were followed up for 52 weeks. CR was sustained in 24 of 74 patients (32%), and the median remission time was 30 weeks. In the multivariable analysis, the maintenance therapy with IMs was demonstrated as a significant positive factor of sustained CR up to 52 weeks (p = 0.038, OR 2.214). The rate of sustained CR in patients with 5-ASA and IMs was not different when compared with that in patients with 5-ASA only (p = 0.248). On the other hands, the rate of sustained CR in patients with biologics and IMs was significantly higher than that in patients with biologics only (p = 0.002).Conclusion: GMA was more effective for patients with active UC that relapsed under treatment without IM. Furthermore, the addition of IMs should be considered in patients on maintenance therapy with biologics after GMA.

The locations of Ly-$\alpha$ emitting galaxies (LAEs) at the end of the Epoch of Reionisation (EoR) are expected to correlate with regions of ionised hydrogen, traced by the redshifted 21~cm hyperfine line. Mapping the neutral hydrogen around regions with detected and localised LAEs offers an avenue to constrain the brightness temperature of the Universe within the EoR by providing an expectation for the spatial distribution of the gas, thereby providing prior information unavailable to power spectrum measurements. We use a test set of 12 hours of observations from the Murchison Widefield Array (MWA) in extended array configuration, to constrain the neutral hydrogen signature of 58 LAEs, detected with the Subaru Hypersuprime Cam in the \textit{Silverrush} survey, centred on $z$=6.58. We assume that detectable emitters reside in the centre of ionised HII bubbles during the end of reionization, and predict the redshifted neutral hydrogen signal corresponding to the remaining neutral regions using a set of different ionised bubble radii. A prewhitening matched filter detector is introduced to assess detectability. We demonstrate the ability to detect, or place limits upon, the amplitude of brightness temperature fluctuations, and the characteristic HII bubble size. With our limited data, we constrain the brightness temperature of neutral hydrogen to $\Delta{\rm T}_B, Comment: 9 pages, 6 figures, accepted for publication in MNRAS

Knowledge about the magnetic fields in supernova remnants (SNRs) is of paramount importance for constraining Galactic cosmic ray acceleration models. It could also indirectly provide information on the interstellar magnetic fields. In this paper, we predict the Faraday dispersion functions (FDFs) of SNRs for the first time. For this study, we use the results of three dimensional (3D) ideal magnetohydrodynamic (MHD) simulations of SNRs expanding into a weak, regular magnetic field. We present the intrinsic FDFs of the shocked region of SNRs for different viewing angles. We find that the FDFs are generally Faraday complex, which implies that conventional rotation measure study is not sufficient to obtain the information on the magnetic fields in the shocked region and Faraday tomography is necessary. We also show that the FDF allows to derive the physical-depth distribution of polarization intensity when the line of sight is parallel to the initial magnetic field orientation. Furthermore, we demonstrate that the location of contact discontinuity can be identified from the radial profile of the width of the FDF with the accuracy of 0.1–0.2 pc.

We present the pulse arrival times and high-precision dispersion measure estimates for 14 millisecond pulsars observed simultaneously in the 300-500 MHz and 1260-1460 MHz frequency bands using the upgraded Giant Metrewave Radio Telescope (uGMRT). The data spans over a baseline of 3.5 years (2018-2021), and is the first official data release made available by the Indian Pulsar Timing Array collaboration. This data release presents a unique opportunity for investigating the interstellar medium effects at low radio frequencies and their impact on the timing precision of pulsar timing array experiments. In addition to the dispersion measure time series and pulse arrival times obtained using both narrowband and wideband timing techniques, we also present the dispersion measure structure function analysis for selected pulsars. Our ongoing investigations regarding the frequency dependence of dispersion measures have been discussed. Based on the preliminary analysis for five millisecond pulsars, we do not find any conclusive evidence of chromaticity in dispersion measures. Data from regular simultaneous two-frequency observations are presented for the first time in this work. This distinctive feature leads us to the highest precision dispersion measure estimates obtained so far for a subset of our sample. Simultaneous multi-band uGMRT observations in Band 3 and Band 5 are crucial for high-precision dispersion measure estimation and for the prospect of expanding the overall frequency coverage upon the combination of data from the various Pulsar Timing Array consortia in the near future. Parts of the data presented in this work are expected to be incorporated into the upcoming third data release of the International Pulsar Timing Array., 23 pages, 21 figures, 3 tables. Published in PASA

An attempt to use combination therapy with anti-tumor necrosis factor α (TNFα) antibodies and tacrolimus (TAC) has been tried to induce remission in ulcerative colitis (UC). However, the optimal dose of TAC in combination therapy with anti-TNFα antibodies (TAC + anti-TNFα therapy) remains unclear. We examined the efficacy of various doses of TAC + anti-TNFα therapy in a mouse colitis model. Dextran sulfate sodium induced colitis model mice were divided into an anti-TNFα antibody monotherapy group and the groups that received various doses of TAC + anti-TNFα therapy. The nuclear factor expression of activated T-cells, cytoplasmic 1 (NFATc1) in the nuclei and the mRNA expression of inflammatory cytokines were assessed by immunohistochemistry and RT-PCR, respectively. The serum anti-TNFα antibody concentration was measured with an enzyme-linked immunosorbent assay. The colon length and histological severity were significantly improved in the groups that received any dose of TAC + anti-TNFα therapy. The nuclear expression of NFATc1 was inversely proportional to the administered doses of TAC. The expression levels of inflammatory cytokines tended to decrease in proportion to the dose of TAC. The serum concentration of anti-TNFα antibodies in the high-dose TAC + anti-TNFα therapy was significantly higher than those in the other groups. Low-dose TAC exerted its immunosuppressive effect on T-cells, and additionally, high-dose TAC maintained the serum anti-TNFα antibody concentration. When administered in combination with anti-TNFα antibodies, the dose of TAC should be adjusted according to the disease severity.

Gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM) was proposed as a new variant of gastric adenocarcinoma of the fundic gland type (GA-FG). However, at present, the influence of Helicobacter pylori and the speed of progression and degree of malignancy in GA-FGM remain unclear. Herein, we report the first case of intramucosal GA-FGM that was endoscopically observed before and after H. pylori eradication over 15 years. The lesion showed the same tumor size with no submucosal invasion and a low MIB-1 labeling index 15 years after its detection using endoscopy. The endoscopic morphology changed from 0-IIa before H. pylori eradication to 0-IIa+IIc and then 0-I after H. pylori eradication. These findings suggest that the unaltered tumor size reflects low-grade malignancy and slow growth, and that the endoscopic morphology is influenced by H. pylori eradication.

To improve the safety and energy density of Li batteries, all-solid-state batteries (ASSBs) are desired. Solid polymer electrolytes (SPEs) are expected to be promising candidates, owing to features such as their high flexibility and formability. To achieve high-performance ASSBs, we investigated molecular structure design by fabricating two types of SPEs. First, chemically cross-linked polyethylene oxide/polypropylene oxide (P(EO/PO))-based SPEs were formed with low-molecular-weight PEO as side chains. Second, physically cross-linked SPEs were fabricated with short PEO chains (G2) as soft-units and norbornene (NB) as hard-units with intramolecular phase separation. Evaluation of the physicochemical and electrochemical properties of these SPEs was carried out, and the degree of dissociation of the Li salt was investigated by Raman spectroscopy. The phenomenon of decoupling between the segmental motion of the SPEs and ionic conduction was confirmed by Vogel-Fulcher-Tamman equation analysis. P(NB/G2)-based SPEs also exhibited high thermal stability, which originated from the NB unit, according to TG-DTA and DSC measurements. Furthermore, ionic conductivity increased monotonically with the Li salt concentration, in contrast to conventional PEO-based SPEs. Physically cross-linked SPEs achieved the decoupling of ionic conduction from their segmental motion owing to their differences between the ionic and structural components of the SPEs.

A 60-year-old man had received octreotide for a metastatic neuroendocrine tumor (NET) in the rectum. Computed tomography and ultrasonography revealed a cardiac tumor, diffuse thickness of the ventricular wall and pericardial effusion, which was diagnosed as cardiac metastasis. The metastatic lesions continued to grow despite the alteration of chemotherapy, and the patient complained of repeated syncope and was admitted to our hospital at 11 months after the diagnosis of cardiac metastasis. An electrocardiogram during syncope showed sustained ventricular tachycardia, which was considered to be caused by the cardiac metastasis. We herein report a case of NET with cardiac metastasis which caused lethal arrhythmia along with a review of the pertinent literature.

A 24-year-old woman was admitted to our hospital due to abdominal pain and a high fever. She was diagnosed with ileocolonic Crohn's disease (CD), complicated with a gastro-colic fistula and splenomegaly. After initial treatment with an infliximab-biosimilar, all blood cell line counts markedly decreased. Three-dimensional reconstructed computed tomography revealed splenic vein narrowing. Thus, her pancytopenia was deemed to have likely been caused by hypersplenism. Surgery was performed, and clinical remission was maintained without pancytopenia. This is the first report of a CD patient with pancytopenia caused by hypersplenism that was triggered by gastro-colic fistula-associated splenic vein obstruction.

Background Endoscopic submucosal dissection (ESD) is currently a common procedure although it requires a long procedural time. We conducted a prospective study to determine the efficacy and safety of lidocaine injection for shortening the procedural time and relieving bowel peristalsis during ESD. Methods A multicenter randomized controlled study was conducted in three hospitals. Ninety-one patients who underwent colorectal ESD were enrolled. Patients were randomly divided into two groups using the envelope method: the lidocaine group and saline group. The primary endpoint was the procedural time, and the secondary endpoints were the procedural time in each part of the colon and the grade of bowel peristalsis and the incidence and amounts of antispasmodic drugs use and adverse events. Results The patients’ demographics were not markedly different between the two groups. The mean procedural time in the lidocaine group was not markedly different from that in the saline group. In contrast, at the proximal site, the procedural time in the lidocaine group (57 min) was significantly shorter in the saline group (80 min). The grade of bowel peristalsis in the lidocaine group (0.67) was significantly lower than in the saline group (1.17). Antispasmodic drug use was significantly rarer in the lidocaine group than in the saline group. The incidence of adverse events was not markedly different between the two groups. Conclusions Local lidocaine injection is a feasible option for preventing bowel peristalsis, particularly in the proximal colon, leading to a reduced procedural time for ESD and decreased antispasmodic drug use. University Hospital Medical Information Network Center (UMIN number: 000022843).

To control the fluoride dissociation and conduction of polyether-based solid polymer electrolytes, an electrolyte system composed of a host polymer, metal salt, and anion acceptor was proposed. Appropriate choices of metal salt with low lattice enthalpy and anion acceptor concentration were important to obtain polymer electrolytes with high fluoride conductivity. The results of thermal and electrochemical measurements revealed that the optimal electrolyte system displayed a relatively high fluoride conductivity of ca. 1 × 10−6 S cm−1 at 303 K and fluoride transference number of over 0.8 (80%).

Detecting $\rm H_I$ 21cm line in the intergalactic medium (IGM) during the Epoch of Reionization (EoR) suffers from foreground contamination such as Galactic synchrotron and extragalactic radio sources. Cross-correlation between the 21cm line and Lyman-$\alpha$ emitter (LAE) galaxies is a powerful tool to identify the 21cm signal since the 21cm line emission has correlation with LAEs while the LAEs are statistically independent of the foregrounds. So far, the detectability of 21cm-LAE cross-power spectrum has been investigated with simple LAE models where the observed Ly$\alpha$ luminosity is proportional to the dark matter halo mass. However, the previous models were inconsistent with the latest observational data of LAEs obtained with Subaru/Hyper Suprime-Cam (HSC). Here, we revisit the detectability of 21cm-LAE cross-power spectrum adopting a state-of-the-art LAE model consistent with all Subaru/HSC observations such as the Ly$\alpha$ luminosity function, LAE angular auto-correlation, and the LAE fractions in the continuum selected galaxies. We find that resultant cross-power spectrum with the updated LAE model is reduced at small scales ($k\sim 1\ \rm Mpc^{-1}$) compared to the simple models, while the amplitudes at large scales ($k \lesssim 0.2 \ \rm Mpc^{-1}$) are not affected so much. We conclude that the large-scale signal would be detectable with Square Kilometre Array (SKA) and HSC LAE cross-correlation but detecting the small scale signal would require an extended HSC LAE survey with an area of $\sim 75\ \rm deg^2$ or 3000 hrs observation time of 21cm line with SKA., Comment: 11 pages, 10 figures, accepted to Monthly Notices of the Royal Astronomical Society

It is very computationally expensive to search for pulsars using time-domain observations, and the volume of data will be enormous with next-generation telescopes such as the Square Kilometre Array. We use artificial neural networks (ANNs), a machine learning method, for the efficient selection of pulsar candidates from radio continuum surveys; this is much cheaper than using time-domain observations. With observed quantities such as radio fluxes, sky position and compactness as inputs, our ANNs output the ‘score’ that indicates the degree of likeliness that an object is a pulsar. We demonstrate ANNs based on existing survey data by the Tata Institute for Fundamental Research (TIFR) Giant Metrewave Radio Telescope (GMRT) Sky Survey (TGSS) and the National Radio Astronomy Observatory (NRAO) Very Large Array (VLA) Sky Survey (NVSS) and we test their performance. The precision, which is the ratio of the number of pulsars classified correctly as pulsars to the number of any objects classified as pulsars, is about $96 {{\ \rm per\ cent}}$. Finally, we apply the trained ANNs to unidentified radio sources and our fiducial ANN with five inputs (the galactic longitude and latitude, the TGSS and NVSS fluxes and compactness) generates 2436 pulsar candidates from 456 866 unidentified radio sources. We need to confirm whether these candidates are truly pulsars by using time-domain observations. More information, such as polarization, will narrow the number of candidates down further.

Faraday tomography is a novel method to probe 3-dimensional structure of magnetic fields of polarized radio sources. In this paper, we investigate Faraday dispersion function (FDF) of disk galaxies extending a simple analytic model of galactic magnetic fields developed in Ideguchi et al. (2017). The model consists of axisymmetric coherent fields and turbulent fields and we consider the effects of inclination, relative amplitude of coherent and turbulent magnetic fields and pitch angle of coherent fields. Our simple model makes it easy to obtain physical interpretation of FDFs and helps understanding observational results. We find FDFs have two peaks when galaxies are observed with non zero inclination. The gap and relative height of two peaks are dependent on the inclination angle and pitch angle but are not affected by relative amplitude of coherent and turbulent magnetic fields so much. These findings give us an important caution that two peaks in observed FDFs do not necessarily imply the presence of two separate radio sources within a beam.

Decades long monitoring of millisecond pulsars, which exhibit highly stable rotational periods, in pulsar timing array experiments is on the threshold of discovering nanohertz stochastic gravitational wave background. This paper describes the Indian Pulsar timing array (InPTA) experiment, which employs the upgraded Giant Metrewave Radio Telescope (uGMRT) for timing an ensemble of millisecond pulsars for this purpose. We highlight InPTA's observation strategies and analysis methods, which are relevant for a future PTA experiment with the more sensitive Square Kilometer Array (SKA) telescope. We show that the unique multi-sub-array multi-band wide-bandwidth frequency coverage of the InPTA provides Dispersion Measure estimates with unprecedented precision for PTA pulsars, e.g., ~ 2 x 10{-5} pc-cm{-3} for PSR J1909-3744. Configuring the SKA-low and SKA-mid as two and four sub-arrays respectively, it is shown that comparable precision is achievable, using observation strategies similar to those pursued by the InPTA, for a larger sample of 62 pulsars requiring about 26 and 7 hours per epoch for the SKA-mid and the SKA-low telescopes respectively. We also review the ongoing efforts to develop PTA-relevant general relativistic constructs that will be required to search for nanohertz gravitational waves from isolated super-massive black hole binary systems like blazar OJ 287. These efforts should be relevant to pursue persistent multi-messenger gravitational wave astronomy during the forthcoming era of the SKA telescope, the Thirty Meter Telescope, and the next-generation Event Horizon Telescope., Comment: Accepted for publication in Journal of Astronomy and Astrophysics for Special Issue on Indian Participation in the SKA (Editors : Abhirup Datta, Nirupam Roy, Preeti Kharb and Tirthankar Roy Choudhury)

High-precision measurements of the pulsar dispersion measure (DM) are possible using telescopes with low-frequency wideband receivers. We present an initial study of the application of the wideband timing technique, which can simultaneously measure the pulsar times of arrival (ToAs) and DMs, for a set of five pulsars observed with the upgraded Giant Metrewave Radio Telescope (uGMRT) as part of the Indian Pulsar Timing Array (InPTA) campaign. We have used the observations with the 300-500 MHz band of the uGMRT for this purpose. We obtain high precision in DM measurements with precisions of the order 10^{-6}cm^{-3}pc. The ToAs obtained have sub-{\mu}s precision and the root-mean-square of the post-fit ToA residuals are in the sub-{\mu}s range. We find that the uncertainties in the DMs and ToAs obtained with this wideband technique, applied to low-frequency data, are consistent with the results obtained with traditional pulsar timing techniques and comparable to high-frequency results from other PTAs. This work opens up an interesting possibility of using low-frequency wideband observations for precision pulsar timing and gravitational wave detection with similar precision as high-frequency observations used conventionally., Comment: Accepted for publication in MNRAS

Faraday tomography through broadband polarimetry can provide crucial information on magnetized astronomical objects, such as quasars, galaxies, or galaxy clusters. However, the limited wavelength coverage of the instruments requires that we solve an ill-posed inverse problem when we want to obtain the Faraday dispersion function (FDF), a tomographic distribution of the magnetoionic media along the line of sight. This paper explores the use of wavelet transforms and the sparsity of the transformed FDFs in the form of wavelet shrinkage (WS) for finding better solutions to the inverse problem. We recently proposed the Constraining and Restoring iterative Algorithm for Faraday Tomography (CRAFT; Cooray et al. 2021), a new flexible algorithm that showed significant improvements over the popular methods such as Rotation Measure Synthesis. In this work, we introduce CRAFT+WS, a new version of CRAFT incorporating the ideas of wavelets and sparsity. CRAFT+WS exhibit significant improvements over the original CRAFT when tested for a complex FDF of realistic Galactic model. Reconstructions of FDFs demonstrate super-resolution in Faraday depth, uncovering previously unseen Faraday complexities in observations. The proposed approach will be necessary for effective cosmic magnetism studies using the Square Kilometre Array and its precursors., 10 Pages, 3 Figures, Submitted to PASJ. Code will be made available upon publication

Background Chemotherapy for advanced gastric cancer is recommended in the guidelines; however, later‐line treatment remains controversial. Since immune checkpoint inhibitors have been used for the treatment of various malignancies, trials have been performed for gastric cancer. A phase 3 trial indicated the survival benefit of nivolumab monotherapy for gastric cancer patients treated with prior chemotherapy regimens. Patients and methods A regional cohort study was undertaken to determine the real‐world data of nivolumab treatment for patients with advanced or recurrent gastric cancer. The patients were enrolled for 2 years from October 2017 to October 2019 and were prospectively followed for 1 year to examine the overall survival (OS). The patient characteristics were analyzed in a multivariate analysis and a nomogram to predict the probability of survival was generated. Results In total, 70 patients who received nivolumab as ≥third‐line chemotherapy were included in the Asahikawa Gastric Cancer Cohort. The median OS was 7.5 (95% CI, 4.8–10.2) months and the response rate was 18.6%. Diffuse type classification, bone metastasis, high neutrophil/lymphocyte ratio, and high CRP were associated with poor OS/prognosis in the multivariate analysis. A nomogram was developed based on these clinical parameters and the concordance index was 0.80 (95% CI, 0.68–0.91). The responders were aged and were frequently diagnosed with intestinal type gastric cancer, including patients with a HER2‐positive status (27.3%) or microsatellite instability‐high (27.3%) status. Conclusions The regional cohort study of nivolumab monotherapy for gastric cancer patients revealed prognostic factors and a nomogram was developed that could predict the probability of survival., Development and validation of the nomogram. The nomogram of different risk factors for survival at 7.5 months in gastric cancer patients treated with nivolumab.

Background Carbazochrome sodium sulfonate (CSS) is conventionally administered to prevent post-endoscopic submucosal dissection (ESD) bleeding in many institutions, but research on its preventive efficacy is lacking. Therefore, we investigated the risk of post-ESD bleeding and the preventive efficacy of CSS administration. Methods We retrospectively reviewed 304 lesions in 259 patients with gastric neoplasms who underwent ESD at Asahikawa Medical University Hospital from 2014 to 2021. In the CSS group, CSS 100 mg/day was intravenously infused with maintenance fluid replacement on postoperative days 0–2. The risk factors of post-ESD bleeding, including CSS administration, were investigated. Results The overall rate of post-ESD bleeding was 4.6% (14/304). The univariate analysis showed that atrial fibrillation (Af), warfarin intake, heparin replacement, and tumor location in the lower third were significant risk factors for increasing the likelihood of postoperative bleeding. In the multivariate analysis, Af (odds ratio [OR] 3.83, 95% CI 1.02–14.30; p p p p = 0.783). Additionally, CSS was not shown to have preventive effects in groups with higher-risk factors, such as Af diagnosis, warfarin use, heparin replacement, and tumor location in the lower third of the stomach. Conclusion CSS administration was not effective for the prevention of the post-ESD bleeding in the overall patient population as well as in higher-risk patients. This suggests that the administration of CSS for post-ESD bleeding prevention may need to be reconsidered.

Background Granulocyte and monocyte adsorptive apheresis (GMA) is widely used as a remission induction therapy for active ulcerative colitis (UC) patients. However, there are no available biomarkers for predicting the clinical outcome of GMA. We investigated the utility of Fecal calprotectin (FC) as a biomarker for predicting the clinical outcome during GMA therapy in active UC patients. Methods In this multicenter prospective observation study, all patients received 10 sessions of GMA, twice a week, for 5 consecutive weeks. FC was measured at entry, one week, two weeks, and at the end of GMA. Colonoscopy was performed at entry and after GMA. The clinical activity was assessed based on the partial Mayo score when FC was measured. Clinical remission (CR) was defined as a partial Mayo score of ≤ 2 and endoscopic remission (ER) was defined as Mayo endoscopic subscore of either 0 or 1. We analyzed the relationships between the clinical outcome (CR and ER) and the change in FC concentration. Result Twenty-six patients were included in this study. The overall CR and ER rates were 50.0% and 19.2%, respectively. After GMA, the median FC concentration in patients with ER was significantly lower than that in patients without ER (469 mg/kg vs. 3107 mg/kg, p = 0.03). When the cut-off value of FC concentration was set at 1150 mg/kg for assessing ER after GMA, the sensitivity and specificity were 0.8 and 0.81, respectively. The FC concentration had significantly decreased by one week. An ROC analysis demonstrated that the reduction rate of FC (ΔFC) at 1 week was the most accurate predictor of CR at the end of GMA (AUC = 0.852, P = 0.002). When the cut-off value of ΔFC was set at ≤ 40% at 1 week for predicting CR at the end of GMA, the sensitivity and specificity were 76.9% and 84.6%, respectively. Conclusion We evaluated the utility of FC as a biomarker for assessing ER after GMA and predicting CR in the early phase during GMA in patients with active UC. Our findings will benefit patients with active UC by allowing them to avoid unnecessary invasive procedures and will help establish new strategies for GMA.

The supply of oven-fresh bakery products to consumers has been improved by frozen dough technology; however, freeze-thaw stress decreases the activity of yeast cells. To breed better baker's yeasts for frozen dough, it is important to understand the factors affecting freeze-thaw stress tolerance in baker's yeast. We analyzed the stress response in IB1411, a spore clone from Saccharomyces cerevisiae Shirakami kodama yeast, with an exceptionally high tolerance to freeze-thaw stress. Genes encoding trehalose-6-phosphate synthase (TPS1), catalase (CTT1), and disaggregase (HSP104) were highly expressed in IB1411 cells even under conditions of non-stress. The expression of Hsp104 protein was also higher in IB1411 cells even under non-stress conditions. Deletion of HSP104 (hsp104Δ) in IB1411 cells reduced the activity of the ubiquitin-proteasome system (UPS). By monitoring the accumulation of aggregated proteins using the ΔssCPY*-GFP fusion protein under freeze-thaw stress or treatment with proteasomal inhibitor, we found that IB1411 cells resolved aggregated proteins faster than the hsp104Δ strain. Thus, Hsp104 seems to contribute to freeze-thaw tolerance by maintaining UPS activity via the disaggregation of aggregated proteins. Lastly, we found that the IB1411 cells maintained high leavening ability in frozen dough as compared with the parental strain, Shirakami kodama yeast, and thus will be useful for making bread.

BACKGROUND Epstein-Barr virus (EBV)-associated carcinoma is a gastric cancer subtype with a morphology characterized by gastric carcinoma with lymphoid stroma (GCLS). Clinicopathological studies have indicated a better prognosis for GCLS than for common gastric carcinomas. Some previous cases of early gastric cancer associated with EBV had been diagnosed by endoscopic resection. CASE SUMMARY We present two GCLS cases subjected to endoscopic submucosal dissection (ESD) for a definitive diagnosis. A protruded gastric lesion was identified by routine endoscopic examination, but forceps biopsy showed no atypical cells before ESD. The resected specimen showed a poorly differentiated adenocarcinoma with lymphoid cells involving the mucosa and submucosa. The final diagnosis was submucosa-invasive poorly differentiated gastric adenocarcinoma. Accordingly, additional gastrectomy was recommended to obtain a complete cure. One patient underwent additional distal gastrectomy with lymph node dissection, but the other was refused because of cardiovascular complications. Both patients remained in remission for more than half a year. EBV positivity was determined by EBV-encoded RNA in situ hybridization. We also conducted a literature review of cases of early gastric cancer associated with EBV that had been diagnosed by ESD. CONCLUSION Submucosa-invasive GCLS could be dissected using ESD, and EBV positivity should be subsequently assessed to determine whether or not any additional curative surgery is required. Further prospective investigations on the prevalence of lymph node metastasis in EBV-associated carcinoma should be performed to expand the indications for endoscopic resection.

A new detection method for gravitational waves (GWs) with ultra-low frequencies ($f_{\rm GW} \lesssim 10^{-10}~{\rm Hz}$), which is much lower than the range of pulsar timing arrays (PTAs), was proposed in Yonemaru et al. (2016). This method utilizes the statistical properties of spin-down rates of milli-second pulsars (MSPs) and the sensitivity was evaluated in Yonemaru et al. (2018). There, some simplifying assumptions, such as neglect of the "pulsar term" and spatially uniform distribution of MSPs, were adopted and the sensitivity on the time derivative of GW amplitude was estimated to be $10^{-19}~{\rm s}^{-1}$ independent of the direction, polarization and frequency of GWs. In this paper, extending the previous analysis, realistic simulations are performed to evaluate the sensitivity more reasonably. We adopt a model of 3-dimensional pulsar distribution in our Galaxy and take the pulsar term into account. As a result, we obtain expected sensitivity as a function of the direction, polarization and frequency of GWs. The dependence on GW frequency is particularly significant and the sensitivity becomes worse by a few orders for $< 10^{-12}~{\rm Hz}$ compared to the previous estimates., 7 pages, 9 figures, submit to MNRAS

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creat iveco mmons .org/licen ses/by/4.0/), BACKGROUND: Steroid therapy is primarily used to prevent esophageal stricture after endoscopic submucosal dissection (ESD). However, esophageal stricture can still occur after preventive therapy, and the effect of preventive steroid therapy cannot be predicted before stricture formation. This study aimed to clarify the risk factors for esophageal stricture after preventive steroid therapy. METHODS: This was a retrospective study conducted at three institutions. From January 2011 to February 2018, 28 large-sized SENs in 26 patients who had a mucosal defect that involved more than three-quarters of the esophageal circumference were enrolled. We classified white coats on artificial ulcers after esophageal ESD into three groups (thin, moderately thick, thick) based on endoscopic images obtained on postoperative day 7. RESULTS: The white coat status on the artificial ulcer after ESD was a significant risk factor for post-ESD stricture (p