1. Sodium‐glucose co‐transporter 2 inhibitors in acute heart failure: real‐world prescription trends and outcomes analysis
- Author
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Saki Mizobuchi, Yuki Saito, Daisuke Kitano, Kazuto Toyama, Masatsugu Miyagawa, Yutaka Koyama, Hidesato Fujito, Keisuke Kojima, Nobuhiro Murata, Daisuke Fukamachi, and Yasuo Okumura
- Subjects
Acute heart failure ,Prognosis ,Prescription trends ,Sodium‐glucose co‐transporter 2 inhibitors ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims Sodium‐glucose co‐transporter 2 (SGLT2) inhibitors have shown potential therapeutic benefits in heart failure (HF). However, data on their real‐world usage and benefits in acute decompensated heart failure (ADHF) are limited. Methods and results We conducted a post hoc analysis of real‐world data from 1108 patients with ADHF admitted to Nihon University Itabashi Hospital (Tokyo, Japan) between 2018 and 2022. Patients were divided into two groups based on the prescription of SGLT2 inhibitors during hospitalization: an SGLT2 inhibitor group (SGLT2i group) (n = 289) and a non‐SGLT2i group (n = 819). The primary endpoints were death and rehospitalization for HF after discharge. The median age was 76 [interquartile range (IQR): 66, 83] years, and 732 patients (66%) were male. Data showed an increasing trend in the prescription of SGLT2 inhibitors since 2021. During a median follow‐up period of 366 days (IQR: 116, 614), 458 (41.3%) patients reached the primary endpoint. The Kaplan–Meier analysis showed that the SGLT2i group had a significantly lower rate of composite events than the non‐SGLT2i group, both overall (log‐rank test, P
- Published
- 2024
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