1. [Clinical condition and therapy of bone diseases]
- Author
-
Kohji, Miura and Keiichi, Oznono
- Subjects
Bone Density Conservation Agents ,Diphosphonates ,Limb Deformities, Congenital ,Hypophosphatasia ,Pamidronate ,Dwarfism ,Natriuretic Peptide, C-Type ,Osteogenesis Imperfecta ,Alkaline Phosphatase ,Bone and Bones ,Collagen Type I ,Recombinant Proteins ,Achondroplasia ,Collagen Type I, alpha 1 Chain ,Mice ,Mutation ,Lordosis ,Animals ,Humans ,Receptor, Fibroblast Growth Factor, Type 3 ,Molecular Targeted Therapy - Abstract
Skeletal dysplasia is the term which represents disorders including growth and differentiation of bone, cartilage and ligament. A lot of diseases are included, and new disorders have been added. However, the therapy of most bone diseases is less well-established. Achondroplasia, hypochondroplasia, and osteogenesis imperfecta are most frequent bone diseases. There is no curative treatment for these diseases, however, supportive therapies are available ; for example, growth-hormone therapy for achondroplasia and hypochondroplasia, and bisphosphonate therapy for osteogenesis imperfecta. In addition, enzyme replacement therapy for hypophosphatasia is now on clinical trial.
- Published
- 2013