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1. Seroprevalence trends of anti-SARS-CoV-2 antibodies and associated risk factors: a population-based study

Author

Tancredi, Stefano, Chiolero, Arnaud, Wagner, Cornelia, Haller, Moa Lina, Chocano-Bedoya, Patricia, Ortega, Natalia, Rodondi, Nicolas, Kaufmann, Laurent, Lorthe, Elsa, Baysson, Hélène, Stringhini, Silvia, Michel, Gisela, Lüdi, Chantal, Harju, Erika, Frank, Irene, Imboden, Medea, Witzig, Melissa, Keidel, Dirk, Probst-Hensch, Nicole, Amati, Rebecca, Albanese, Emiliano, Corna, Laurie, Crivelli, Luca, Vincentini, Julia, Gonseth Nusslé, Semira, Bochud, Murielle, D’Acremont, Valérie, Kohler, Philipp, Kahlert, Christian R., Cusini, Alexia, Frei, Anja, Puhan, Milo A., Geigges, Marco, Kaufmann, Marco, Fehr, Jan, and Cullati, Stéphane

Published
2023
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3. Changes in socioeconomic resources and mental health after the second COVID-19 wave (2020–2021): a longitudinal study in Switzerland

Author

Tancredi, Stefano, Ulytė, Agnė, Wagner, Cornelia, Keidel, Dirk, Witzig, Melissa, Imboden, Medea, Probst-Hensch, Nicole, Amati, Rebecca, Albanese, Emiliano, Levati, Sara, Crivelli, Luca, Kohler, Philipp, Cusini, Alexia, Kahlert, Christian, Harju, Erika, Michel, Gisela, Lüdi, Chantal, Ortega, Natalia, Baggio, Stéphanie, Chocano-Bedoya, Patricia, Rodondi, Nicolas, Ballouz, Tala, Frei, Anja, Kaufmann, Marco, Von Wyl, Viktor, Lorthe, Elsa, Baysson, Hélène, Stringhini, Silvia, Schneider, Valentine, Kaufmann, Laurent, Wieber, Frank, Volken, Thomas, Zysset, Annina, Dratva, Julia, and Cullati, Stéphane

Published
2023
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4. Residential greenspace and lung function decline over 20 years in a prospective cohort: The ECRHS study

Author

Markevych, Iana, Zhao, Tianyu, Fuertes, Elaine, Marcon, Alessandro, Dadvand, Payam, Vienneau, Danielle, Garcia Aymerich, Judith, Nowak, Dennis, de Hoogh, Kees, Jarvis, Deborah, Abramson, Michael J., Accordini, Simone, Amaral, Andre FS, Bentouhami, Hayat, Jacobsen Bertelsen, Randi, Boudier, Anne, Bono, Roberto, Bowatte, Gayan, Casas, Lidia, Dharmage, Shyamali C, Forsberg, Bertil, Gislason, Thorarinn, Gnesi, Marco, Holm, Mathias, Jacquemin, Benedicte, Janson, Christer, Jogi, Rain, Johannessen, Ane, Keidel, Dirk, Leynaert, Benedicte, Maldonado Perez, José Antonio, Marchetti, Pierpaolo, Migliore, Enrica, Martínez-Moratalla, Jesús, Orru, Hans, Pin, Isabelle, Potts, James, Probst-Hensch, Nicole, Ranzi, Andrea, Sánchez-Ramos, José Luis, Siroux, Valerie, Soussan, David, Sunyer, Jordi, Urrutia Landa, Isabel, Villani, Simona, and Heinrich, Joachim

Published
2023
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6. Socioeconomic Status and Adherence to Preventive Measures During the COVID-19 Pandemic in Switzerland: A Population Based Digital Cohort Analysis

Author

Michel, Gisela, Harju, Erika, Frank, Irène, Tancredi, Stefano, van der Linden, Bernadette W. A., Chiolero, Arnaud, Cullati, Stéphane, Imboden, Medea, Probst-Hensch, Nicole, Keidel, Dirk, Witzig, Melissa, Dratva, Julia, Frank, Irene, Lorthe, Elsa, Baysson, Hélène, Stringhini, Silvia, Kahlert, Christian R., Bardoczi, Julia B., Haller, Moa Lina, Chocano-Bedoya, Patricia O., Rodondi, Nicolas, Amati, Rebecca, Albanese, Emiliano, Corna, Laurie, Crivelli, Luca, Kaufmann, Marco, Frei, Anja, von Wyl, Viktor, Michel, Gisela, Harju, Erika, Frank, Irène, Tancredi, Stefano, van der Linden, Bernadette W. A., Chiolero, Arnaud, Cullati, Stéphane, Imboden, Medea, Probst-Hensch, Nicole, Keidel, Dirk, Witzig, Melissa, Dratva, Julia, Frank, Irene, Lorthe, Elsa, Baysson, Hélène, Stringhini, Silvia, Kahlert, Christian R., Bardoczi, Julia B., Haller, Moa Lina, Chocano-Bedoya, Patricia O., Rodondi, Nicolas, Amati, Rebecca, Albanese, Emiliano, Corna, Laurie, Crivelli, Luca, Kaufmann, Marco, Frei, Anja, and von Wyl, Viktor

Abstract

Objectives: To assess the association between socioeconomic status (SES) and self-reported adherence to preventive measures in Switzerland during the COVID-19 pandemic. Methods: 4,299 participants from a digital cohort were followed between September 2020 and November 2021. Baseline equivalised disposable income and education were used as SES proxies. Adherence was assessed over time. We investigated the association between SES and adherence using multivariable mixed logistic regression, stratifying by age (below/above 65 years) and two periods (before/after June 2021, to account for changes in vaccine coverage and epidemiological situation). Results: Adherence was high across all SES strata before June 2021. After, participants with higher equivalised disposable income were less likely to adhere to preventive measures compared to participants in the first (low) quartile [second (Adj.OR, 95% CI) (0.56, 0.37–0.85), third (0.38, 0.23–0.64), fourth (0.60, 0.36–0.98)]. We observed similar results for education. Conclusion: No differences by SES were found during the period with high SARS-CoV-2 incidence rates and stringent measures. Following the broad availability of vaccines, lower incidence, and eased measures, differences by SES started to emerge. Our study highlights the need for contextual interpretation when assessing SES impact on adherence to preventive measures., + ID der Publikation: unilu_75292 + Sprache: Englisch + Bemerkungen: Article 1606861 + Letzte Aktualisierung: 2024-07-16 13:58:51

Published
2024

7. Socioeconomic Status and Adherence to Preventive Measures During the COVID-19 Pandemic in Switzerland: A Population Based Digital Cohort Analysis.

Author

Tancredi, Stefano, van der Linden, Bernadette W. A., Chiolero, Arnaud, Cullati, Stéphane, Imboden, Medea, Probst-Hensch, Nicole, Keidel, Dirk, Witzig, Melissa, Dratva, Julia, Michel, Gisela, Harju, Erika, Frank, Irene, Lorthe, Elsa, Baysson, Hélène, Stringhini, Silvia, Kahlert, Christian R., Bardoczi, Julia B., Haller, Moa Lina, Chocano-Bedoya, Patricia O., and Rodondi, Nicolas

Subjects
COVID-19 pandemic, SOCIOECONOMIC status, VACCINATION coverage, DISPOSABLE income, LOGISTIC regression analysis, SUICIDE statistics
Abstract

Objectives: To assess the association between socioeconomic status (SES) and selfreported adherence to preventive measures in Switzerland during the COVID-19 pandemic. Methods: 4,299 participants from a digital cohort were followed between September 2020 and November 2021. Baseline equivalised disposable income and education were used as SES proxies. Adherence was assessed over time. We investigated the association between SES and adherence using multivariable mixed logistic regression, stratifying by age (below/above 65 years) and two periods (before/after June 2021, to account for changes in vaccine coverage and epidemiological situation). Results: Adherence was high across all SES strata before June 2021. After, participants with higher equivalised disposable income were less likely to adhere to preventive measures compared to participants in the first (low) quartile [second (Adj.OR, 95% CI) (0.56, 0.37-0.85), third (0.38, 0.23-0.64), fourth (0.60, 0.36-0.98)]. We observed similar results for education. Conclusion: No differences by SES were found during the period with high SARS-CoV-2 incidence rates and stringent measures. Following the broad availability of vaccines, lower incidence, and eased measures, differences by SES started to emerge. Our study highlights the need for contextual interpretation when assessing SES impact on adherence to preventive measures. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Restrictive spirometry pattern is associated with low physical activity levels. A population based international study

Author

Carsin, Anne-Elie, Fuertes, Elaine, Schaffner, Emmanuel, Jarvis, Debbie, Antó, Josep M., Heinrich, Joachim, Bellisario, Valeria, Svanes, Cecilie, Keidel, Dirk, Imboden, Medea, Weyler, Joost, Nowak, Dennis, Martinez-Moratalla, Jesus, Gullón, José-Antonio, Sanchez Ramos, José Luis, Caviezel, Seraina, Beckmeyer-Borowko, Anna, Raherison, Chantal, Pin, Isabelle, Demoly, Pascal, Cerveri, Isa, Accordini, Simone, Gislason, Thorarinn, Toren, Kjell, Forsberg, Bertil, Janson, Christer, Jogi, Rain, Emtner, Margareta, Gómez Real, Francisco, Raza, Wasif, Leynaert, Bénédicte, Pascual, Silvia, Guerra, Stefano, Dharmage, Shyamali C., Probst-Hensch, Nicole, and Garcia-Aymerich, Judith

Published
2019
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10. Interplay of Digital Proximity App Use and SARS-CoV-2 Vaccine Uptake in Switzerland: Analysis of Two Population-Based Cohort Studies

Author

Daniore, Paola, primary, Moser, André, additional, Höglinger, Marc, additional, Probst Hensch, Nicole, additional, Imboden, Medea, additional, Vermes, Thomas, additional, Keidel, Dirk, additional, Bochud, Murielle, additional, Ortega Herrero, Natalia, additional, Baggio, Stéphanie, additional, Chocano-Bedoya, Patricia, additional, Rodondi, Nicolas, additional, Tancredi, Stefano, additional, Wagner, Cornelia, additional, Cullati, Stéphane, additional, Stringhini, Silvia, additional, Gonseth Nusslé, Semira, additional, Veys-Takeuchi, Caroline, additional, Zuppinger, Claire, additional, Harju, Erika, additional, Michel, Gisela, additional, Frank, Irène, additional, Kahlert, Christian R., additional, Albanese, Emiliano, additional, Crivelli, Luca, additional, Levati, Sara, additional, Amati, Rebecca, additional, Kaufmann, Marco, additional, Geigges, Marco, additional, Ballouz, Tala, additional, Frei, Anja, additional, Fehr, Jan, additional, and von Wyl, Viktor, additional

Published
2023
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11. Changes in Healthcare Utilization During the COVID-19 Pandemic and Potential Causes—A Cohort Study From Switzerland

Author

Harju, Erika, primary, Speierer, Alexandre, additional, Jungo, Katharina Tabea, additional, Levati, Sara, additional, Baggio, Stéphanie, additional, Tancredi, Stefano, additional, Noor, Nazihah, additional, Rodondi, Pierre-Yves, additional, Cullati, Stéphane, additional, Imboden, Medea, additional, Keidel, Dirk, additional, Witzig, Melissa, additional, Frank, Irène, additional, Kohler, Philipp, additional, Kahlert, Christian, additional, Crivelli, Luca, additional, Amati, Rebecca, additional, Albanese, Emiliano, additional, Kaufmann, Marco, additional, Frei, Anja, additional, von Wyl, Viktor, additional, Puhan, Milo A., additional, Probst-Hensch, Nicole, additional, Michel, Gisela, additional, Rodondi, Nicolas, additional, and Chocano-Bedoya, Patricia, additional

Published
2023
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14. Factors Associated With COVID-19 Non-Vaccination in Switzerland: A Nationwide Study

Author

Sabatini, Serena, primary, Kaufmann, Marco, additional, Fadda, Marta, additional, Tancredi, Stefano, additional, Noor, Nazihah, additional, Van Der Linden, Bernadette W. A., additional, Cullati, Stéphane, additional, Frank, Irene, additional, Michel, Gisela, additional, Harju, Erika, additional, Luedi, Chantal, additional, Frei, Anja, additional, Ballouz, Tala, additional, Menges, Dominik, additional, Fehr, Jan, additional, Kohler, Philipp, additional, Kahlert, Christian R., additional, Scheu, Victor, additional, Ortega, Natalia, additional, Chocano-Bedoya, Patricia, additional, Rodondi, Nicolas, additional, Stringhini, Silvia, additional, Baysson, Hélène, additional, Lorthe, Elsa, additional, Zufferey, Maria Caiata, additional, Suggs, L. Suzanne, additional, Albanese, Emiliano, additional, Vincentini, Julia, additional, Bochud, Murielle, additional, D’Acremont, Valérie, additional, Nusslé, Samira Gonseth, additional, Imboden, Medea, additional, Keidel, Dirk, additional, Witzig, Melissa, additional, Probst-Hensch, Nicole, additional, and von Wyl, Viktor, additional

Published
2023
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15. An assessment on the interplay of digital proximity app use and vaccine uptake for SARS-CoV-2 transmission mitigation in Switzerland

Author

Daniore, Paola, primary, Moser, André, additional, Höglinger, Marc, additional, Probst Hensch, Nicole, additional, Imboden, Medea, additional, Vermes, Thomas, additional, Keidel, Dirk, additional, Bochud, Murielle, additional, Ortega Herrero, Natalia, additional, Baggio, Stéphanie, additional, Chocano-Bedoya, Patricia, additional, Rodondi, Nicolas, additional, Tancredi, Stefano, additional, Wagner, Cornelia, additional, Cullati, Stéphane, additional, Stringhini, Silvia, additional, Gonseth Nusslé, Semira, additional, Veys-Takeuchi, Caroline, additional, Zuppinger, Claire, additional, Harju, Erika, additional, Michel, Gisela, additional, Frank, Irène, additional, Kahlert, Christian, additional, Albanese, Emiliano, additional, Crivelli, Luca, additional, Levati, Sara, additional, Amati, Rebecca, additional, Kaufmann, Marco, additional, Geigges, Marco, additional, Ballouz, Tala, additional, Frei, Anja, additional, Fehr, Jan, additional, and von Wyl, Viktor, additional

Published
2023
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16. Factors Associated With COVID-19 Non-Vaccination in Switzerland: A Nationwide Study

Author

Sabatini, Serena, Kaufmann, Marco, Fadda, Marta, Tancredi, Stefano, Noor, Nazihah, Van der Linden, Bernadette W. A., Cullati, Stéphanie, Frank, Irène, Michel, Gisela, Harju, Erika, Lüdi, Chantal, Frei, Anja, Ballouz, Tala, Menges, Dominik, Fehr, Jan, Kohler, Philipp, Kahlert, Christian R., Scheu, Victor, Ortega, Natalia, Chocano-Bedoya, Patricia, Rodondi, Nicolas, Stringhini, Silvia, Baysson, Hélène, Lorthe, Elsa, Zufferey, Maria Caiata, Suggs, L. Suzanne, Albanese, Emiliano, Vincentini, Julia, Bochud, Murielle, D'Acremont, Valérie, Nusslé, Samira Gonseth, Imboden, Medea, Keidel, Dirk, Witzig, Melissa, Probst-Hensch, Nicole, Von Wyl, Viktor, Sabatini, Serena, Kaufmann, Marco, Fadda, Marta, Tancredi, Stefano, Noor, Nazihah, Van der Linden, Bernadette W. A., Cullati, Stéphanie, Frank, Irène, Michel, Gisela, Harju, Erika, Lüdi, Chantal, Frei, Anja, Ballouz, Tala, Menges, Dominik, Fehr, Jan, Kohler, Philipp, Kahlert, Christian R., Scheu, Victor, Ortega, Natalia, Chocano-Bedoya, Patricia, Rodondi, Nicolas, Stringhini, Silvia, Baysson, Hélène, Lorthe, Elsa, Zufferey, Maria Caiata, Suggs, L. Suzanne, Albanese, Emiliano, Vincentini, Julia, Bochud, Murielle, D'Acremont, Valérie, Nusslé, Samira Gonseth, Imboden, Medea, Keidel, Dirk, Witzig, Melissa, Probst-Hensch, Nicole, and Von Wyl, Viktor

Abstract

Objectives: We compared socio-demographic characteristics, health-related variables, vaccination-related beliefs and attitudes, vaccination acceptance, and personality traits of individuals who vaccinated against COVID-19 and who did not vaccinate by December 2021.Methods: This cross-sectional study used data of 10,642 adult participants from the Corona Immunitas eCohort, an age-stratified random sample of the population of several cantons in Switzerland. We used multivariable logistic regression models to explore associations of vaccination status with socio-demographic, health, and behavioral factors.Results: Non-vaccinated individuals represented 12.4% of the sample. Compared to vaccinated individuals, non-vaccinated individuals were more likely to be younger, healthier, employed, have lower income, not worried about their health, have previously tested positive for SARS-CoV-2 infection, express lower vaccination acceptance, and/or report higher conscientiousness. Among non-vaccinated individuals, 19.9% and 21.3% had low confidence in the safety and effectiveness of SARS-CoV-2 vaccine, respectively. However, 29.1% and 26.7% of individuals with concerns about vaccine effectiveness and side effects at baseline, respectively vaccinated during the study period.Conclusion: In addition to known socio-demographic and health-related factors, non-vaccination was associated with concerns regarding vaccine safety and effectiveness., + ID der Publikation: unilu_68453 + Sprache: Englisch + Letzte Aktualisierung: 2023-06-30 12:14:10

Published
2023

17. Changes in healthcare utilization during the COVID-19 pandemic and potential causes : a cohort study from Switzerland

Author

Harju, Erika, Speierer, Alexandre, Jungo, Katharina Tabea, Levati, Sara, Baggio, Stéphanie, Tancredi, Stefano, Noor, Nazihah, Rodondi, Pierre-Yves, Cullati, Stéphane, Imboden, Medea, Keidel, Dirk, Witzig, Melissa, Frank, Irène, Kohler, Philipp, Kahlert, Christian, Crivelli, Luca, Amati, Rebecca, Albanese, Emiliano, Kaufmann, Marco, Frei, Anja, von Wyl, Viktor, Puhan, Milo A., Probst-Hensch, Nicole, Michel, Gisela, Rodondi, Nicolas, Chocano-Bedoya, Patricia, Harju, Erika, Speierer, Alexandre, Jungo, Katharina Tabea, Levati, Sara, Baggio, Stéphanie, Tancredi, Stefano, Noor, Nazihah, Rodondi, Pierre-Yves, Cullati, Stéphane, Imboden, Medea, Keidel, Dirk, Witzig, Melissa, Frank, Irène, Kohler, Philipp, Kahlert, Christian, Crivelli, Luca, Amati, Rebecca, Albanese, Emiliano, Kaufmann, Marco, Frei, Anja, von Wyl, Viktor, Puhan, Milo A., Probst-Hensch, Nicole, Michel, Gisela, Rodondi, Nicolas, and Chocano-Bedoya, Patricia

Abstract

Objectives: To describe the frequency of and reasons for changes in healthcare utilization in those requiring ongoing treatment, and to assess characteristics associated with change, during the second wave of the pandemic. Methods: Corona Immunitas e-cohort study (age ≥20 years) participants completed monthly questionnaires. We compared participants reporting a change in healthcare utilization with those who did not using descriptive and bivariate statistics. We explored characteristics associated with the number of changes using negative binomial regression. Results: The study included 3,190 participants from nine research sites. One-fifth reported requiring regular treatment. Among these, 14% reported a change in healthcare utilization, defined as events in which participants reported that they changed their ongoing treatment, irrespective of the reason. Reasons for change were medication changes and side-effects, specifically for hypertension, or pulmonary embolism treatment. Females were more likely to report changes [Incidence Rate Ratio (IRR) = 2.15, p = 0.002]. Those with hypertension were least likely to report changes [IRR = 0.35, p = 0.019]. Conclusion: Few of those requiring regular treatment reported changes in healthcare utilization. Continuity of care for females and chronic diseases besides hypertension must be emphasized.

Published
2023

18. Interplay of digital proximity app use and SARS-CoV-2 vaccine uptake in Switzerland : analysis of two population-based cohort studies

Author

Daniore, Paola, Moser, André, Höglinger, Marc, Probst Hensch, Nicole, Imboden, Medea, Vermes, Thomas, Keidel, Dirk, Bochud, Murielle, Ortega Herrero, Natalia, Baggio, Stéphanie, Chocano-Bedoya, Patricia, Rodondi, Nicolas, Tancredi, Stefano, Wagner, Cornelia, Cullati, Stéphane, Stringhini, Silvia, Gonseth Nusslé, Semira, Veys-Takeuchi, Caroline, Zuppinger, Claire, Harju, Erika, Michel, Gisela, Frank, Irène, Kahlert, Christian R., Albanese, Emiliano, Crivelli, Luca, Levati, Sara, Amati, Rebecca, Kaufmann, Marco, Geigges, Marco, Ballouz, Tala, Frei, Anja, Fehr, Jan, von Wyl, Viktor, Daniore, Paola, Moser, André, Höglinger, Marc, Probst Hensch, Nicole, Imboden, Medea, Vermes, Thomas, Keidel, Dirk, Bochud, Murielle, Ortega Herrero, Natalia, Baggio, Stéphanie, Chocano-Bedoya, Patricia, Rodondi, Nicolas, Tancredi, Stefano, Wagner, Cornelia, Cullati, Stéphane, Stringhini, Silvia, Gonseth Nusslé, Semira, Veys-Takeuchi, Caroline, Zuppinger, Claire, Harju, Erika, Michel, Gisela, Frank, Irène, Kahlert, Christian R., Albanese, Emiliano, Crivelli, Luca, Levati, Sara, Amati, Rebecca, Kaufmann, Marco, Geigges, Marco, Ballouz, Tala, Frei, Anja, Fehr, Jan, and von Wyl, Viktor

Abstract

Objectives: Our study aims to evaluate developments in vaccine uptake and digital proximity tracing app use in a localized context of the SARS-CoV-2 pandemic. Methods: We report findings from two population-based longitudinal cohorts in Switzerland from January to December 2021. Failure time analyses and Cox proportional hazards regression models were conducted to assess vaccine uptake and digital proximity tracing app (SwissCovid) uninstalling outcomes. Results: We observed a dichotomy of individuals who did not use the SwissCovid app and did not get vaccinated, and who used the SwissCovid app and got vaccinated during the study period. Increased vaccine uptake was observed with SwissCovid app use (aHR, 1.51; 95% CI: 1.40–1.62 [CI-DFU]; aHR, 1.79; 95% CI: 1.62–1.99 [CSM]) compared to SwissCovid app non-use. Decreased SwissCovid uninstallation risk was observed for participants who got vaccinated (aHR, 0.55; 95% CI: 0.38–0.81 [CI-DFU]; aHR, 0.45; 95% CI: 0.27–0.78 [CSM]) compared to participants who did not get vaccinated. Conclusion: In evolving epidemic contexts, these findings underscore the need for communication strategies as well as flexible digital proximity tracing app adjustments that accommodate different preventive measures and their anticipated interactions.

Published
2023

21. Additional file 1 of Changes in socioeconomic resources and mental health after the second COVID-19 wave (2020–2021): a longitudinal study in Switzerland

Author

Tancredi, Stefano, Ulytė, Agnė, Wagner, Cornelia, Keidel, Dirk, Witzig, Melissa, Imboden, Medea, Probst-Hensch, Nicole, Amati, Rebecca, Albanese, Emiliano, Levati, Sara, Crivelli, Luca, Kohler, Philipp, Cusini, Alexia, Kahlert, Christian, Harju, Erika, Michel, Gisela, Lüdi, Chantal, Ortega, Natalia, Baggio, Stéphanie, Chocano-Bedoya, Patricia, Rodondi, Nicolas, Ballouz, Tala, Frei, Anja, Kaufmann, Marco, Von Wyl, Viktor, Lorthe, Elsa, Baysson, Hélène, Stringhini, Silvia, Schneider, Valentine, Kaufmann, Laurent, Wieber, Frank, Volken, Thomas, Zysset, Annina, Dratva, Julia, and Cullati, Stéphane

Abstract

Additional file 1. Supplementary figures and tables

Published
2023
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22. D15.6 - Results of the joint survey on HBM mixtures

Author

Ottenbros, Ilse, Lebret, Erik, Huber, Carolin, Lommen, Arjen, Antignac, Jean-Philippe, Čupr, Pavel, Šulc, Libor, Szigeti, Tamás, Középesy, Szilvia, Martinsone, Inese, Martinsone, Zanna, Pardo, Olga, Fernández, Sandra, Coscollá, Clara, Pedraza Diaz, Susana, Ammann, Priska, Jacobs, Anne, Probst-Hensch, Nicole, Imboden, Medea, Keidel, Dirk, Krauss, Martin, Debrauwer, Laurent, Wagner, Kevin, Nijssen, Rosalie, Mol, Hans, Vitale, Chiara Maria, Klanova, Jana, Garlito, Borja, León, Nuria, Luijten, Mirjam, and Vlaanderen, Jelle

Abstract

This deliverable describes the results of the joint pesticide survey ’SPECIMEn’ in five partner countries: Czech Republic, Hungary, Latvia, Spain and the Netherlands. It also contains a report on the implementation of a study conducted in Switzerland, which has a different design, but data was harmonised as much as possible. In all participating partner countries, urine samples have been collected in two seasons, i.e., winter 2019/2020 and summer 2020. Per country at least 100 locations have been included, of which about half are located in so-called hotspot areas. On the collected urine samples, a harmonised suspect screening method was applied to detect multiple pesticide-related markers. The deliverable describes the results obtained with this analysis.

Published
2022
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23. Residential exposure to greenspace and life satisfaction in times of COVID-19: a cross-sectional analysis of 9444 participants from a population-based study in Basel-Stadt and Basel-Landschaft

Author

Jeong, Ayoung, primary, Galliker, Fiona, additional, Imboden, Medea, additional, Keidel, Dirk, additional, De Hoogh, Kees, additional, Vienneau, Danielle, additional, Siegrist, Michael, additional, Crivelli, Luca, additional, Lovison, Gianfranco, additional, and Probst-Hensch, Nicole, additional

Published
2022
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24. The Corona Immunitas Digital Follow-Up eCohort to Monitor Impacts of the SARS-CoV-2 Pandemic in Switzerland: Study Protocol and First Results

Author

Speierer, Alexandre, Chocano-Bedoya, Patricia O., Anker, Daniela, Schmid, Alexia, Keidel, Dirk, Vermes, Thomas, Imboden, Medea, Levati, Sara, Franscella, Giovanni, Corna, Laurie, Amati, Rebecca, Harju, Erika, Lüdi, Chantal, Michel, Gisela, Veys-Takeuchi, Caroline, Zuppinger, Claire, Nusslé, Semira Gonseth, D'Acremont, Valérie, Tall, Ismaël, Salberg, Éric, Baysson, Hélène, Lorthe, Elsa, Pernacchio, Francesco, Frei, Anja, Kaufmann, Marco, Geigges, Marco, West, Erin Ashley, Schwab, Nathalie, Cullati, Stéphanie, Chiolero, Arnaud, Kahlert, Christian, Stringhini, Silvia, Vollrath, Fabian, Probst-Hensch, Nicole, Rodondi, Nicolas, Puhan, Milo A., von Wyl, Viktor, Speierer, Alexandre, Chocano-Bedoya, Patricia O., Anker, Daniela, Schmid, Alexia, Keidel, Dirk, Vermes, Thomas, Imboden, Medea, Levati, Sara, Franscella, Giovanni, Corna, Laurie, Amati, Rebecca, Harju, Erika, Lüdi, Chantal, Michel, Gisela, Veys-Takeuchi, Caroline, Zuppinger, Claire, Nusslé, Semira Gonseth, D'Acremont, Valérie, Tall, Ismaël, Salberg, Éric, Baysson, Hélène, Lorthe, Elsa, Pernacchio, Francesco, Frei, Anja, Kaufmann, Marco, Geigges, Marco, West, Erin Ashley, Schwab, Nathalie, Cullati, Stéphanie, Chiolero, Arnaud, Kahlert, Christian, Stringhini, Silvia, Vollrath, Fabian, Probst-Hensch, Nicole, Rodondi, Nicolas, Puhan, Milo A., and von Wyl, Viktor

Abstract

Objectives: To describe the rationale, organization, and procedures of the Corona Immunitas Digital Follow-Up (CI-DFU) eCohort and to characterize participants at baseline.Methods: Participants of Corona Immunitas, a population-based nationwide SARS-CoV-2 seroprevalence study in Switzerland, were invited to join the CI-DFU eCohort in 11 study centres. Weekly online questonnaires cover health status changes, prevention measures adherence, and social impacts. Monthly questionnaires cover additional prevention adherence, contact tracing apps use, vaccination and vaccine hesitancy, and socio-economic changes.Results: We report data from the 5 centres that enrolled in the CI-DFU between June and October 2020 (covering Basel City/Land, Fribourg, Neuchâtel, Ticino, Zurich). As of February 2021, 4636 participants were enrolled and 85,693 weekly and 27,817 monthly questionnaires were collected. Design-based oversampling led to overrepresentation of individuals aged 65+ years. People with higher education and income were more likely to enroll and be retained.Conclusion: Broad enrolment and robust retention of participants enables scientifically sound monitoring of pandemic impacts, prevention, and vaccination progress. The CI-DFU eCohort demonstrates proof-of-principle for large-scale, federated eCohort study designs based on jointly agreed principles and transparent governance., + ID der Publikation: unilu_58669 + Sprache: Englisch + Letzte Aktualisierung: 2022-03-02 15:24:20

Published
2022

26. Results of the joint survey on HBM mixtures Deliverable Report D15.6 WP15 Mixtures, HBM and human health risks

Author

Mirjiam Luijten, Lebret, Erik, Huber, Carolin, Jean-Philippe Antignac, Cupr, Pavel, Sulc, Libor, Szigeti, Tamas, Kozepesy, Szilvia, Martinsone, Inese, Martinsone, Zanna, Pardo, Olga, Fernández, Sandra F., Coscollà, Clara, Pedraza, Susana, Ammann, Priska, Jacobs, Anne, Probst-Hensch, Nicole, Imboden, Medea, Keidel, Dirk, Krauss, Martin, Debrauwer, Laurent, Wagner, Kevin, Nijssen, Rosalie, H. G.J. Mol, Vitale, Chiara Maria, Klanova, Jana, Molina, Borja Garlito, and León, Nuria

Published
2022
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27. The Corona Immunitas Digital Follow-Up eCohort to Monitor Impacts of the SARS-CoV-2 Pandemic in Switzerland: Study Protocol and First Results

Author

Speierer, Alexandre, primary, Chocano-Bedoya, Patricia O., additional, Anker, Daniela, additional, Schmid, Alexia, additional, Keidel, Dirk, additional, Vermes, Thomas, additional, Imboden, Medea, additional, Levati, Sara, additional, Franscella, Giovanni, additional, Corna, Laurie, additional, Amati, Rebecca, additional, Harju, Erika, additional, Luedi, Chantal, additional, Michel, Gisela, additional, Veys-Takeuchi, Caroline, additional, Zuppinger, Claire, additional, Nusslé, Semira Gonseth, additional, D’Acremont, Valérie, additional, Tall, Ismaël, additional, Salberg, Éric, additional, Baysson, Hélène, additional, Lorthe, Elsa, additional, Pennacchio, Francesco, additional, Frei, Anja, additional, Kaufmann, Marco, additional, Geigges, Marco, additional, West, Erin Ashley, additional, Schwab, Nathalie, additional, Cullati, Stéphane, additional, Chiolero, Arnaud, additional, Kahlert, Christian, additional, Stringhini, Silvia, additional, Vollrath, Fabian, additional, Probst-Hensch, Nicole, additional, Rodondi, Nicolas, additional, Puhan, Milo A., additional, and von Wyl, Viktor, additional

Published
2022
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30. Cumulative Occupational Exposures and Lung Function Decline in Two Large General Population Cohorts

Author

Lytras, Theodore, Beckmeyer-Borowko, Anna, Kogevinas, Manolis, Kromhout, Hans, Carsin, Anne-Elie, Antó, Josep Maria, Bentouhami, Hayat, Weyler, Joost, Heinrich, Joachim, Nowak, Dennis, Urrutia, Isabel, Martínez-Moratalla, Jesús, Gullón, José Antonio, Pereira Vega, Antonio, Raherison Semjen, Chantal, Pin, Isabelle, Demoly, Pascal, Leynaert, Bénédicte, Villani, Simona, Gislason, Thorarinn, Svanes, Øistein, Holm, Mathias, Forsberg, Bertil, Norbäck, Dan, Mehta, Amar J, Keidel, Dirk, Vernez, David, Benke, Geza, Jõgi, Rain, Torén, Kjell, Sigsgaard, Torben, Schlünssen, Vivi, Olivieri, Mario, Blanc, Paul D, Watkins, John, Bono, Roberto, Squillacioti, Giulia, Buist, A Sonia, Vermeulen, Roel, Jarvis, Deborah, Probst-Hensch, Nicole, Zock, Jan-Paul, Lytras, Theodore, Beckmeyer-Borowko, Anna, Kogevinas, Manolis, Kromhout, Hans, Carsin, Anne-Elie, Antó, Josep Maria, Bentouhami, Hayat, Weyler, Joost, Heinrich, Joachim, Nowak, Dennis, Urrutia, Isabel, Martínez-Moratalla, Jesús, Gullón, José Antonio, Pereira Vega, Antonio, Raherison Semjen, Chantal, Pin, Isabelle, Demoly, Pascal, Leynaert, Bénédicte, Villani, Simona, Gislason, Thorarinn, Svanes, Øistein, Holm, Mathias, Forsberg, Bertil, Norbäck, Dan, Mehta, Amar J, Keidel, Dirk, Vernez, David, Benke, Geza, Jõgi, Rain, Torén, Kjell, Sigsgaard, Torben, Schlünssen, Vivi, Olivieri, Mario, Blanc, Paul D, Watkins, John, Bono, Roberto, Squillacioti, Giulia, Buist, A Sonia, Vermeulen, Roel, Jarvis, Deborah, Probst-Hensch, Nicole, and Zock, Jan-Paul

Abstract

RATIONALE: Few longitudinal studies have assessed the relationship between occupational exposures and lung function decline in the general population, with sufficiently long follow-up.OBJECTIVES: Our objective was to examine this potential association in two large cohorts (ECRHS and SAPALDIA).METHODS: General population samples aged 18 to 62 were randomly selected in 1991-1993, and followed up approximately 10 and 20 years later. Spirometry (without bronchodilation) was performed at each visit. Coded complete job histories during follow-up visits were linked to a Job-Exposure Matrix, generating cumulative exposure estimates for 12 occupational exposures. FEV1 and FVC were jointly modelled in linear mixed-effects models, fitted in a Bayesian framework, taking into account age and smoking.RESULTS: A total of 40,024 lung function measurements from 17,833 study participants were analyzed. We found accelerated declines in FEV1 and the FEV1/FVC ratio for exposure to biological dust, mineral dust and metals (FEV1 -15.1ml, -14.4ml and -18.7ml respectively, and FEV1/FVC -0.52%, -0.43% and -0.36% respectively, per 25 intensity-years of exposure). These declines were comparable in magnitude to those associated with long-term smoking. No effect modification by sex or smoking status was identified. Findings were similar between the ECRHS and SAPALDIA cohorts.CONCLUSIONS: Our results greatly strengthen the evidence base implicating occupation, independent of smoking, as a risk factor for lung function decline. This highlights the need to prevent or control these exposures in the workplace.

Published
2021

31. Cumulative Occupational Exposures and Lung Function Decline in Two Large General Population Cohorts

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Dep IRAS, Lytras, Theodore, Beckmeyer-Borowko, Anna, Kogevinas, Manolis, Kromhout, Hans, Carsin, Anne-Elie, Antó, Josep Maria, Bentouhami, Hayat, Weyler, Joost, Heinrich, Joachim, Nowak, Dennis, Urrutia, Isabel, Martínez-Moratalla, Jesús, Gullón, José Antonio, Pereira Vega, Antonio, Raherison Semjen, Chantal, Pin, Isabelle, Demoly, Pascal, Leynaert, Bénédicte, Villani, Simona, Gislason, Thorarinn, Svanes, Øistein, Holm, Mathias, Forsberg, Bertil, Norbäck, Dan, Mehta, Amar J, Keidel, Dirk, Vernez, David, Benke, Geza, Jõgi, Rain, Torén, Kjell, Sigsgaard, Torben, Schlünssen, Vivi, Olivieri, Mario, Blanc, Paul D, Watkins, John, Bono, Roberto, Squillacioti, Giulia, Buist, A Sonia, Vermeulen, Roel, Jarvis, Deborah, Probst-Hensch, Nicole, Zock, Jan-Paul, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Dep IRAS, Lytras, Theodore, Beckmeyer-Borowko, Anna, Kogevinas, Manolis, Kromhout, Hans, Carsin, Anne-Elie, Antó, Josep Maria, Bentouhami, Hayat, Weyler, Joost, Heinrich, Joachim, Nowak, Dennis, Urrutia, Isabel, Martínez-Moratalla, Jesús, Gullón, José Antonio, Pereira Vega, Antonio, Raherison Semjen, Chantal, Pin, Isabelle, Demoly, Pascal, Leynaert, Bénédicte, Villani, Simona, Gislason, Thorarinn, Svanes, Øistein, Holm, Mathias, Forsberg, Bertil, Norbäck, Dan, Mehta, Amar J, Keidel, Dirk, Vernez, David, Benke, Geza, Jõgi, Rain, Torén, Kjell, Sigsgaard, Torben, Schlünssen, Vivi, Olivieri, Mario, Blanc, Paul D, Watkins, John, Bono, Roberto, Squillacioti, Giulia, Buist, A Sonia, Vermeulen, Roel, Jarvis, Deborah, Probst-Hensch, Nicole, and Zock, Jan-Paul

Published
2021

32. Transportation noise and blood pressure in a population - based sample of adults

Author

Drata, Julia, Phuleria, Harish C., Foraster, Maria, Gaspoz, Jean-Michel, Keidel, Dirk, Kunzli, Nino, Liu, L.J. Sally, Pons, Marco, Zemp, Elisabeth, Gerbase, Margaret W., and Schindle, Christian

Subjects
Heart diseases -- Risk factors -- Research, Blood pressure -- Physiological aspects -- Research, Transportation noise -- Health aspects -- Research, Adults -- Health aspects, Environmental issues, Health
Abstract

BACKGROUND: There is some evidence for an association between traffic noise and ischemic heart disease; however, associations with blood pressure have been inconsistent, and little is known about health effects [...]

Published
2012

33. Cross-sectional associations between air pollution and chronic bronchitis: an ESCAPE meta-analysis across five cohorts

Author

Cai, Yutong, Schikowski, Tamara, Adam, Martin, Buschka, Anna, Carsin, Anne-Elie, Jacquemin, Benedicte, Marcon, Alessandro, Sanchez, Margaux, Vierkötter, Andrea, Al-Kanaani, Zaina, Beelen, Rob, Birk, Matthias, Brunekreef, Bert, Cirach, Marta, Clavel-Chapelon, Françoise, Declercq, Christophe, de Hoogh, Kees, de Nazelle, Audrey, Ducret-Stich, Regina E, Ferretti, Virginia Valeria, Forsberg, Bertil, Gerbase, Margaret W, Hardy, Rebecca, Heinrich, Joachim, Hoek, Gerard, Jarvis, Debbie, Keidel, Dirk, Kuh, Diana, Nieuwenhuijsen, Mark J, Ragettli, Martina S, Ranzi, Andrea, Rochat, Thierry, Schindler, Christian, Sugiri, Dorothea, Temam, Sofia, Tsai, Ming-Yi, Varraso, Raphaëlle, Kauffmann, Francine, Krämer, Ursula, Sunyer, Jordi, Künzli, Nino, Probst-Hensch, Nicole, and Hansell, Anna L

Published
2014
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34. Variants associated with HHIP expression have sex-differential effects on lung function

Author

Fawcett, Katherine A., primary, Obeidat, Ma'en, additional, Melbourne, Carl A., additional, Shrine, Nick, additional, Guyatt, Anna L., additional, John, Catherine, additional, Luan, Jian'an, additional, Richmond, Anne, additional, Moksnes, Marta R., additional, Granell, Raquel, additional, Weiss, Stefan, additional, Imboden, Medea, additional, May-Wilson, Sebastian, additional, Hysi, Pirro, additional, Boutin, Thibaud S., additional, Portas, Laura, additional, Flexeder, Claudia, additional, Harris, Sarah E., additional, Wang, Carol A., additional, Lyytikäinen, Leo-Pekka, additional, Palviainen, Teemu, additional, Foong, Rachel E., additional, Keidel, Dirk, additional, Minelli, Cosetta, additional, Langenberg, Claudia, additional, Bossé, Yohan, additional, Van den Berge, Maarten, additional, Sin, Don D., additional, Hao, Ke, additional, Campbell, Archie, additional, Porteous, David, additional, Padmanabhan, Sandosh, additional, Smith, Blair H., additional, Evans, David M., additional, Ring, Sue, additional, Langhammer, Arnulf, additional, Hveem, Kristian, additional, Willer, Cristen, additional, Ewert, Ralf, additional, Stubbe, Beate, additional, Pirastu, Nicola, additional, Klaric, Lucija, additional, Joshi, Peter K., additional, Patasova, Karina, additional, Massimo, Mangino, additional, Polasek, Ozren, additional, Starr, John M., additional, Karrasch, Stefan, additional, Strauch, Konstantin, additional, Meitinger, Thomas, additional, Rudan, Igor, additional, Rantanen, Taina, additional, Pietiläinen, Kirsi, additional, Kähönen, Mika, additional, Raitakari, Olli T., additional, Hall, Graham L., additional, Sly, Peter D., additional, Pennell, Craig E., additional, Kaprio, Jaakko, additional, Lehtimäki, Terho, additional, Vitart, Veronique, additional, Deary, Ian J., additional, Jarvis, Debbie, additional, Wilson, James F., additional, Spector, Tim, additional, Probst-Hensch, Nicole, additional, Wareham, Nicholas J., additional, Völzke, Henry, additional, Henderson, John, additional, Strachan, David P., additional, Brumpton, Ben M., additional, Hayward, Caroline, additional, Hall, Ian P., additional, Tobin, Martin D., additional, and Wain, Louise V., additional

Published
2021
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36. Regular physical activity levels and incidence of restrictive spirometry pattern: a longitudinal analysis of two population-based cohorts

Author

Carsin, Anne-Elie, Keidel, Dirk, Fuertes, Elaine, Imboden, Medea, Weyler, Joost, Nowak, Dennis, Heinrich, Joachim, Pascual Erquicia Silvia, Martinez-Moratalla, Jesus, Huerta, Ismael, Sanchez, Jose-Luis, Schaffner, Emmanuel, Caviezel, Serena, Beckmeyer-Borowko, Anna, Raherison, Chantal, Pin, Isabelle, Demoly, Pascal, Leynaert, Bénédicte, Cerveri, Isa, Squillacioti, Giulia, Accordini, Simone, Gislason, Thorarinn, Svanes, Cecilie, Toren, Kjell, Forsberg, Bertil, Janson, Christer, Jogi, Rain, Emtner, Margareta, Gómez Real Francisco, Jarvis, Debbie, Guerra, Stefano, Dharmage Shyamali, C, Probst-Hensch, Nicole, Garcia-Aymerich, Judith, and European Union's Horizon 2020 research and innovation programme

Subjects
BMI, FVC, Physical activity, restrictive spirometry, spirometry, Adult, Aged, 80 and over, Male, Epidemiology, Incidence, Vital Capacity, physical activity, Middle Aged, Respiration Disorders, Europe, Forced Expiratory Volume, Humans, Female, Longitudinal Studies, Exercise, 01 Mathematical Sciences, 11 Medical and Health Sciences, Aged
Abstract

A restrictive spirometry pattern is associated with high morbidity and mortality. Whether practicing regular physical activity protects against this pattern has never been studied. We estimated the association between regular physical activity and the incidence of restrictive spirometry pattern. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and physical activity were assessed between 2000–2002 in the ECRHS (n=2,757, 39-67 years) and SAPALDIA (n=2,610, 36–82 years) population-based European cohorts, and again approximately 10-years later (2010–2013). Subjects with restrictive or obstructive spirometry pattern at baseline were excluded. We assessed the association of being active at baseline (defined as being physically active ≥2-3 times/wk for ≥1 h) with restrictive spirometry pattern at follow-up (defined as a post-bronchodilator FEV1/FVC ≥Lower Limit of Normal and FVC

Published
2020

37. Additional file 1 of The modifying role of physical activity in the cross-sectional and longitudinal association of health-related quality of life with physiological functioning-based latent classes and metabolic syndrome

Author

Cerletti, Paco, Keidel, Dirk, Imboden, Medea, Schindler, Christian, and Probst-Hensch, Nicole

Abstract

Additional file 1: Additional Table 1. Baseline characteristics at SAPALDIA 1 of participants who reached the age of 55+ at the time of the SAPALDIA4 55+ health assessments, stratified by participation status in the current study. Additional Table 2. Summary of model fit indices for 1 to 6 latent classes at SAPALDIA4. Additional Table 3. Summary of model fit indices for 1 to 6 latent classes at SAPALDIA3. Additional Table 4. Proportions and class-specific probabilities for the 3 latent classes at SAPALDIA4. Additional Table 5. Proportions and class-specific probabilities for the 3 latent classes at SAPALDIA3. Additional Table 6. Descriptive differences in sex, age and education between the three latent classes, SAPALDIA4. Additional Table 6. Descriptive differences in sex, age and education between the three latent classes, SAPALDIA4. Additional Fig. 1. Descriptive differences of median HRQoL scores of the three latent classes (without adjustment for physical activity) at SAPALDIA4. Additional Table 7. Cross-sectional adjusted HQRoL associations of categories combining physical activity with latent classes (A7A) as well as metabolic syndrome (A7B) (SAPALDIA4). Additional Table 8. Cross-sectional associations of composite variable categories defined by latent classes (A8A) and metabolic syndrome (A8B), respectively, and physical activity status, with median levels of HRQoL, subjects not reporting any cardiovascular disease (SAPALDIA4). Additional Table 9. Prospective associations of composite variable categories defined by latent classes (A9A) and metabolic syndrome (A9B), respectively, and physical activity status at SAPALDIA3, with median levels of HRQoL at SAPALDIA4, adjusted for respective HRQoL domain at SAPALDIA3, subjects not reporting any cardiovascular at SAPALDIA4. Additional Table 10. Cross-sectional associations of composite variable categories defined by latent classes (A10A) and metabolic syndrome (A10B), respectively, and physical activity status with health service utilization in the last 12 months, subjects not reporting any cardiovascular (SAPALDIA4).

Published
2020
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38. Fawcett_et_al_Extended_data_supplement.docx

Author

Fawcett, Katherine, Ma'en Obeidat, Melbourne, Carl, Shrine, Nick, Guyatt, Anna, John, Catherine, Jian'an Luan, Richmond, Anne, Moksnes, Marta, Granell, Raquel, Weiss, Stefan, Imboden, Medea, May-Wilson, Sebastian, Hysi, Pirro, Boutin, Thibaud, Portas, Laura, Flexeder, Claudia, Harris, Sarah, Wang, Carol, Leo-Pekka Lyytikäinen, Palviainen, Teemu, Foong, Rachel, Keidel, Dirk, Minelli, Cosetta, Langenberg, Claudia, Yohan Bosse, Berge, Maarten Van Den, Sin, Don, Hao, Ke, Campbell, Archie, Porteous, David, Sandosh Padmanabhan, Smith, Blair, Evans, David, Ring, Sue, Langhammer, Arnulf, Hveem, Kristian, Cristen Willer, Ewert, Ralf, Stubbe, Beate, Pirastu, Nicola, Klaric, Lucija, Joshi, Peter, Patasova, Karina, Mangino, Massimo, Polasek, Ozren, Starr, John, Karrasch, Stefan, Strauch, Konstantin, Meitinger, Thomas, Rudan, Igor, Rantanen, Taina, Pietilainen, Kirsi, Kahonen, Mika, Raitakari, Olli, Hall, Graham, Sly, Peter, Pennell, Craig, Kaprio, Jaakko, Lehtimaki, Terho, Vitart, Veronique, Deary, Ian, Jarvis, Debbie, Wilson, James, Spector, Tim, Probst-Hensch, Nicole, Wareham, Nick, Völzke, Henry, Henderson, John, Strachan, David, Brumpton, Ben, Hayward, Caroline, Hall, Ian, Tobin, Martin, and Wain, Louise

Abstract

This document comprises supplementary materials and methods and extended data for the paper entitled: "Variants associated with HHIP expression have sex-differential effects on lung function", which has been submitted to Wellcome Open Research. Main materials and methods and funding can be found in the main manuscript document.

Published
2020
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39. Genome-wide sex interaction study summary statistics for lung function traits in UK Biobank

Author

Fawcett, Katherine, Ma'en Obeidat, Melbourne, Carl, Shrine, Nick, Guyatt, Anna, John, Catherine, Jian'an Luan, Richmond, Anne, Moksnes, Marta, Granell, Raquel, Weiss, Stefan, Imboden, Medea, May-Wilson, Sebastian, Hysi, Pirro, Boutin, Thibaud, Portas, Laura, Flexeder, Claudia, Harris, Sarah, Wang, Carol, Leo-Pekka Lyytikäinen, Palviainen, Teemu, Foong, Rachel, Keidel, Dirk, Minelli, Cosetta, Langenberg, Claudia, Yohan Bosse, Berge, Maarten Van Den, Sin, Don, Hao, Ke, Campbell, Archie, Porteous, David, Sandosh Padmanabhan, Smith, Blair, Evans, David, Ring, Sue, Langhammer, Arnulf, Hveem, Kristian, Cristen Willer, Ewert, Ralf, Stubbe, Beate, Pirastu, Nicola, Klaric, Lucija, Joshi, Peter, Patasova, Karina, Mangino, Massimo, Polasek, Ozren, Starr, John M, Karrasch, Stefan, Strauch, Konstantin, Meitinger, Thomas, Rudan, Igor, Rantanen, Taina, Pietilainen, Kirsi, Kahonen, Mika, Raitakari, Olli, Hall, Graham, Sly, Peter, Pennell, Craig, Kaprio, Jaakko, Lehtimaki, Terho, Vitart, Veronique, Deary, Ian, Jarvis, Debbie, Wilson, James, Spector, Tim, Probst-Hensch, Nicole, Wareham, Nick, Völzke, Henry, Henderson, John, Strachan, David, Brumpton, Ben, Hayward, Caroline, Hall, Ian, Tobin, Martin, and Wain, Louise

Abstract

These summary statistics are derived from a genome-wide sex interaction study on spirometry-based lung function traits (forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), the ratio of FEV1 and FVC (FEV1/FVC), and peak expiratory flow (PEF) in UK Biobank. Summary statistics are contained within the following files (one for each outcome). Coordinates are genome build hg19 (GRCh37).FawcettKA_prePMID_FEV1.tsv.gzFawcettKA_prePMID_FEV1_FVC_ratio.tsv.gzFawcettKA_prePMID_FVC.tsv.gzFawcettKA_prePMID_PEF.tsv.gzThe following columns are provided: variant_id, p_value, chromosome, base_pair_location, effect_allele, other_allele, effect_allele_frequency, beta, and standard_errorThis study used anonymised data from UK Biobank (RRID: SCR_012815), which comprises over 500,000 volunteer participants aged 40-69 years recruited across Great Britain between 2006 and 2010. The protocol and consent were approved by the UK Biobank’s Research Ethics Committee. Our analysis was conducted under approved UK Biobank data application number 648. Individuals were included in this study if (i) they had no missing data for sex, age, height, and smoking status, (ii) their spirometry data passed quality control, as described previously (Shrine et al. Nat Genet. 2019;51(3):481-93. Epub 2019/02/26. doi: 10.1038/s41588-018-0321-7. PubMed PMID: 30804560; PubMed Central PMCID: PMCPMC6397078), (iii) their genetically inferred sex matched their reported sex, (iv) they had genome-wide imputed genetic data, (v) they were of genetically determined European ancestry, and (vi) they were not first- or second-degree relatives of any other individual included in the study. In total, 303,612 individuals met these criteria.Participants' DNA was genotyped using either the Affymetrix Axiom(r) UK BiLEVE array or the Affymetrix Axiom(r) UK Biobank array (Bycroft et al., Nature. 2018 Oct;562(7726):203-209). Genotypes were imputed based on the Human Reference Consortium (HRC panel, as described elsewhere (Bycroft et al.). Variants with minor allele frequency (MAF)Spirometry-based lung function traits FEV1, FEV1/FVC, FVC, and PEF were pre-adjusted for age, age-squared, standing height and smoking status and the residuals rank-transformed to normality using the rntransform function of the GenABEL package (RRID: SCR_001842) in R (RRID: SCR_001905). To test each imputed autosomal variant for an interaction effect, a linear regression model with genotype (additive effect), sex, genotype-by-sex interaction, genotyping array and the first ten ancestry-based principal components included as covariates was implemented using Plink 2.0 software (RRID: SCR_001757) (https://www.cog-genomics.org/plink/2.0/).For further details see the manuscript: Variants associated with HHIP expression have sex-differential effects on lung function. Wellcome Open Research.

Published
2020
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40. Reduced exposure to [PM.sub.10] and attenuated age-related decline in lung function

Author

Downs, Sara H., Schindler, Christian, Liu, L.-J. Sally, Keidel, Dirk, Bayer-Oglesby, Lucy, Brutsche, Martin H., Gerbase, Margarte W., Keller, Roland, Kunzli, Nino, Ackermann-Liebrich, Ursula, Leuenberger, Philippe, Probst-Hensch, Nicole M., Tschopp, Jean-Marie, Zellweger, Jean-Pierre, Rochat, Thierry, and Schwartz, Joel

Subjects
Air pollution -- Health aspects, Air pollution -- Research, Lung diseases -- Health aspects
Abstract

The impact of clean air and reduced exposure to [PM.sub.10] on the lung function in children, as well as adults is discussed. Findings shows that reduction in the exposure to polluted air affects only the lung function that is related to [PM.sub.10].

Published
2007

41. Characterization of source-specific air pollution exposure for a large population-based Swiss Cohort (SAPALDIA)

Author

Liu, L.-J. Sally, Curjuric, Ivan, Keidel, Dirk, Heldstab, Jurg, Kunzli, Nino, Bayer-Oglesby, Lucy, Ackermann-Liebrich, Ursula, and Schindler, Christian

Subjects
Government regulation, Lung diseases -- Risk factors, Air quality management -- Laws, regulations and rules, Air pollution -- Health aspects
Abstract

BACKGROUND: Although the dispersion model approach has been used in some epidemiologic studies to examine health effects of traffic-specific air pollution, no study has evaluated the model predictions vigorously. METHODS: We evaluated total and traffic-specific particulate matter < 10 and < 2.5 [micro]m in aerodynamic diameter ([PM.sub.10], [PM.sub.2.5]), nitrogren dioxide, and nitrogen oxide concentrations predicted by Gaussian dispersion models against fixed-site measurements at different locations, including traffic-impacted, urban-background, and alpine settings between and across cities. The model predictions were then used to estimate individual subjects&apos; historical and cumulative exposures with a temporal trend model. RESULTS: Modeled [PM.sub.10] and [NO.sub.2] predicted at least 55% and 72% of the variability of the measured [PM.sub.10] and [NO.sub.2], respectively. Traffic-specific pollution estimates correlated with the [NO.sub.x] measurements ([R.sup.2] [greater than or equal to] 0.77) for background sites but not for traffic sites. Regional background [PM.sub.10] accounted for most [PM.sub.10] mass in all cities. Whereas traffic [PM.sub.10] accounted for < 20% of the total [PM.sub.10], it varied significantly within cities. The modeling error for [PM.sub.10] was similar within and between cities. Traffic [NO.sub.x] accounted for the majority of [NO.sub.x] mass in urban areas, whereas background [NO.sub.x] accounted for the majority of [NO.sub.x] in rural areas. The within-city [NO.sub.2] modeling error was larger than that between cities. CONCLUSIONS: The dispersion model predicted well the total [PM.sub.10], [NO.sub.x], and [NO.sub.2] and trafficspecific pollution at background sites. However, the model underpredicted traffic [NO.sub.x] and [NO.sub.2] at traffic sites and needs refinement to reflect local conditions. The dispersion model predictions for [PM.sub.10] are suitable for examining individual exposures and health effects within and between cities. KEY WORDS: cohort study, cumulative exposure, dispersion model, exposure assessment, long-term exposure. Environ Health Perspect 115:1638-1645 (2007). doi:10.1289/ehp.10177 available via http://dx.doi.org/ [Online 14 August 2007], Long-term exposure to air pollution, especially particulate matter (PM), has been linked to reduced lung capacity (Ackermann-Liebrich et al. 1997; Gauderman et al. 2004), elevated mortality (Dockery et al. 1993; [...]

Published
2007

42. Regular Physical Activity Levels and Incidence of Restrictive Spirometry Pattern : A Longitudinal Analysis of 2 Population-Based Cohorts

Author

Carsin, Anne-Elie, Keidel, Dirk, Fuertes, Elaine, Imboden, Medea, Weyler, Joost, Nowak, Dennis, Heinrich, Joachim, Pascual Erquicia, Silvia, Martinez-Moratalla, Jesus, Huerta, Ismael, Sanchez, Jose-Luis, Schaffner, Emmanuel, Caviezel, Seraina, Beckmeyer-Borowko, Anna, Raherison, Chantal, Pin, Isabelle, Demoly, Pascal, Leynaert, Bénédicte, Cerveri, Isa, Squillacioti, Giulia, Accordini, Simone, Gislason, Thorarinn, Svanes, Cecilie, Toren, Kjell, Forsberg, Bertill, Janson, Christer, Jögi, Rain, Emtner, Margareta, Gómez Real, Francisco, Jarvis, Debbie, Guerra, Stefano, Dharmage, Shyamali C., Probst-Hensch, Nicole, Garcia-Aymerich, Judith, Carsin, Anne-Elie, Keidel, Dirk, Fuertes, Elaine, Imboden, Medea, Weyler, Joost, Nowak, Dennis, Heinrich, Joachim, Pascual Erquicia, Silvia, Martinez-Moratalla, Jesus, Huerta, Ismael, Sanchez, Jose-Luis, Schaffner, Emmanuel, Caviezel, Seraina, Beckmeyer-Borowko, Anna, Raherison, Chantal, Pin, Isabelle, Demoly, Pascal, Leynaert, Bénédicte, Cerveri, Isa, Squillacioti, Giulia, Accordini, Simone, Gislason, Thorarinn, Svanes, Cecilie, Toren, Kjell, Forsberg, Bertill, Janson, Christer, Jögi, Rain, Emtner, Margareta, Gómez Real, Francisco, Jarvis, Debbie, Guerra, Stefano, Dharmage, Shyamali C., Probst-Hensch, Nicole, and Garcia-Aymerich, Judith

Abstract

We estimated the association between regular physical activity and the incidence of restrictive spirometry pattern. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and physical activity were assessed in 2 population-based European cohorts (European Community Respiratory Health Survey: n = 2,757, aged 39-67 years; and Swiss Study on Air Pollution and Lung and Heart Diseases in Adults: n = 2,610, aged 36-82 years) first in 2000-2002 and again approximately 10 years later (2010-2013). Subjects with restrictive or obstructive spirometry pattern at baseline were excluded. We assessed the association of being active at baseline (defined as being physically active at least 2-3 times/week for ≥1 hour) with restrictive spirometry pattern at follow-up (defined as a postbronchodilation FEV1/FVC ratio of at least the lower limit of normal and FVC of <80% predicted) using modified Poisson regression, adjusting for relevant confounders. After 10 years of follow-up, 3.3% of participants had developed restrictive spirometry pattern. Being physically active was associated with a lower risk of developing this phenotype (relative risk = 0.76, 95% confidence interval: 0.59, 0.98). This association was stronger among those who were overweight and obese than among those of normal weight (P for interaction = 0.06). In 2 large European studies, adults practicing regular physical activity were at lower risk of developing restrictive spirometry pattern over 10 years.

Published
2020
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43. Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991–2003: methods and characterization of participants

Author

Ackermann-Liebrich, Ursula, Kuna-Dibbert, Birgit, Probst-Hensch, Nicole M., Schindler, Christian, Dietrich, Denise Felber, Stutz, Elisabeth Zemp, Bayer-Oglesby, Lucy, Baum, Felix, Brändli, Otto, Brutsche, Martin, Downs, Sara H., Keidel, Dirk, Gerbase, Margaret W., Imboden, Medea, Keller, Roland, Knöpfli, Bruno, Künzli, Nino, Nicod, Laurent, Pons, Marco, Staedele, Patricia, Tschopp, Jean-Marie, Zellweger, Jean-Pierre, Leuenberger, Philippe, and SAPALDIA team

Published
2005
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44. Cumulative Occupational Exposures and Lung-Function Decline in Two Large General-Population Cohorts

Author

Lytras, Theodore, primary, Beckmeyer-Borowko, Anna, additional, Kogevinas, Manolis, additional, Kromhout, Hans, additional, Carsin, Anne-Elie, additional, Antó, Josep Maria, additional, Bentouhami, Hayat, additional, Weyler, Joost, additional, Heinrich, Joachim, additional, Nowak, Dennis, additional, Urrutia, Isabel, additional, Martínez-Moratalla, Jesús, additional, Gullón, José Antonio, additional, Pereira Vega, Antonio, additional, Raherison Semjen, Chantal, additional, Pin, Isabelle, additional, Demoly, Pascal, additional, Leynaert, Bénédicte, additional, Villani, Simona, additional, Gislason, Thorarinn, additional, Svanes, Øistein, additional, Holm, Mathias, additional, Forsberg, Bertil, additional, Norbäck, Dan, additional, Mehta, Amar J., additional, Keidel, Dirk, additional, Vernez, David, additional, Benke, Geza, additional, Jõgi, Rain, additional, Torén, Kjell, additional, Sigsgaard, Torben, additional, Schlünssen, Vivi, additional, Olivieri, Mario, additional, Blanc, Paul D., additional, Watkins, John, additional, Bono, Roberto, additional, Squillacioti, Giulia, additional, Buist, A. Sonia, additional, Vermeulen, Roel, additional, Jarvis, Deborah, additional, Probst-Hensch, Nicole, additional, and Zock, Jan-Paul, additional

Published
2021
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45. Occupational Exposure to Dusts, Gases, and Fumes and Incidence of Chronic Obstructive Pulmonary Disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults

Author

Mehta, Amar J., Miedinger, David, Keidel, Dirk, Bettschart, Robert, Bircher, Andreas, Bridevaux, Pierre-Olivier, Curjuric, Ivan, Kromhout, Hans, Rochat, Thierry, Rothe, Thomas, Russi, Erich W., Schikowski, Tamara, Schindler, Christian, Schwartz, Joel, Turk, Alexander, Vermeulen, Roel, Probst-Hensch, Nicole, and Künzli, Nino

Published
2012
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46. Regular Physical Activity Levels and Incidence of Restrictive Spirometry Pattern: A Longitudinal Analysis of 2 Population-Based Cohorts

Author

Carsin, Anne-Elie, primary, Keidel, Dirk, additional, Fuertes, Elaine, additional, Imboden, Medea, additional, Weyler, Joost, additional, Nowak, Dennis, additional, Heinrich, Joachim, additional, Erquicia, Silvia Pascual, additional, Martinez-Moratalla, Jesus, additional, Huerta, Ismael, additional, Sanchez, Jose-Luis, additional, Schaffner, Emmanuel, additional, Caviezel, Seraina, additional, Beckmeyer-Borowko, Anna, additional, Raherison, Chantal, additional, Pin, Isabelle, additional, Demoly, Pascal, additional, Leynaert, Bénédicte, additional, Cerveri, Isa, additional, Squillacioti, Giulia, additional, Accordini, Simone, additional, Gislason, Thorarinn, additional, Svanes, Cecilie, additional, Toren, Kjell, additional, Forsberg, Bertill, additional, Janson, Christer, additional, Jogi, Rain, additional, Emtner, Margareta, additional, Real, Francisco Gómez, additional, Jarvis, Debbie, additional, Guerra, Stefano, additional, Dharmage, Shyamali C, additional, Probst-Hensch, Nicole, additional, and Garcia-Aymerich, Judith, additional

Published
2020
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47. Variants associated with HHIP expression have sex-differential effects on lung function

Author

Fawcett, Katherine A., primary, Obeidat, Ma'en, additional, Melbourne, Carl, additional, Shrine, Nick, additional, Guyatt, Anna L., additional, John, Catherine, additional, Luan, Jian'an, additional, Richmond, Anne, additional, Moksnes, Marta R., additional, Granell, Raquel, additional, Weiss, Stefan, additional, Imboden, Medea, additional, May-Wilson, Sebastian, additional, Hysi, Pirro, additional, Boutin, Thibaud S., additional, Portas, Laura, additional, Flexeder, Claudia, additional, Harris, Sarah E., additional, Wang, Carol A., additional, Lyytikäinen, Leo-Pekka, additional, Palviainen, Teemu, additional, Foong, Rachel E., additional, Keidel, Dirk, additional, Minelli, Cosetta, additional, Langenberg, Claudia, additional, Bossé, Yohan, additional, Van den Berge, Maarten, additional, Sin, Don D., additional, Hao, Ke, additional, Campbell, Archie, additional, Porteous, David, additional, Padmanabhan, Sandosh, additional, Smith, Blair H., additional, Evans, David M., additional, Ring, Sue, additional, Langhammer, Arnulf, additional, Hveem, Kristian, additional, Willer, Cristen, additional, Ewert, Ralf, additional, Stubbe, Beate, additional, Pirastu, Nicola, additional, Klaric, Lucija, additional, Joshi, Peter K., additional, Patasova, Karina, additional, Massimo, Mangino, additional, Polasek, Ozren, additional, Starr, John M., additional, Karrasch, Stefan, additional, Strauch, Konstantin, additional, Meitinger, Thomas, additional, Rudan, Igor, additional, Rantanen, Taina, additional, Pietiläinen, Kirsi, additional, Kähönen, Mika, additional, Raitakari, Olli T., additional, Hall, Graham L., additional, Sly, Peter D., additional, Pennell, Craig E., additional, Kaprio, Jaakko, additional, Lehtimäki, Terho, additional, Vitart, Veronique, additional, Deary, Ian J., additional, Jarvis, Debbie, additional, Wilson, James F., additional, Spector, Tim, additional, Probst-Hensch, Nicole, additional, Wareham, Nicholas J., additional, Völzke, Henry, additional, Henderson, John, additional, Strachan, David P., additional, Brumpton, Ben M., additional, Hayward, Caroline, additional, Hall, Ian P., additional, Tobin, Martin D., additional, and Wain, Louise V., additional

Published
2020
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50. Particulate matter and subclinical atherosclerosis: associations between different particle sizes and sources with carotid intima-media thickness in the SAPALDIA study

Author

Aguilera, Inmaculada, Dratva, Julia, Caviezel, Seraina, Burdet, Luc, de Groot, Eric, Ducret-Stich, Regina E., Eeftens, Marloes, Keidel, Dirk, Meier, Reto, Perez, Laura, Rothe, Thomas, Schaffner, Emmanuel, Schmit-Trucksass, Arno, Tsai, Ming-Yi, Schindler, Christian, Kunzli, Nino, and Probst-Hensch, Nicole

Subjects
Carotid artery -- Health aspects, Particles -- Research, Atherosclerosis -- Research, Environmental issues, Health
Abstract

BACKGROUND: Subclinical atherosclerosis has been associated with long-term exposure to particulate matter (PM), but the relevance of particle size and sources of exposure remains unclear. OBJECTIVES: We investigated the association of long-term exposure to [PM.sub.10] (≤ 10 µm), [PM.sub.2.5] ([less than or equal to] 2.5 µm: total mass, vehicular, and crustal sources), and ultrafine particles [UFP < 0.1 µm: particle number concentration (PNC) and lung-deposited surface area (LDSA)] with carotid intima-media thickness (CIMT). METHODS: We used data from 1,503 participants [greater than or equal to] 50 years old who participated in the third examination of the Swiss SAPALDIA cohort. Exposures were obtained from dispersion models and land-use regression models. Covariate information, including previous cardiovascular risk factors, was obtained from the second and third SAPALDIA examinations. RESULTS: The adjusted percent difference in CIMT associated with an exposure contrast between the 10th and 90th percentile was 1.58% (95% CI: -0.30, 3.47%) for [PM.sub.10], 2.10% (95% CI: 0.04, 4.16%) for [PM.sub.2.5], 1.67% (95% CI: -0.13, 3.48%) for the vehicular source of [PM.sub.2.5], -0.58% (95% CI: -3.95, 2.79%) for the crustal source of [PM.sub.2.5], 2.06% (95% CI: 0.03, 4.10%) for PNC, and 2.32% (95% CI: 0.23, 4.40%) for LDSA. Stronger associations were observed among diabetics, subjects with low-educational level, and those at higher cardiovascular risk. CONCLUSIONS: CIMT was associated with exposure to [PM.sub.10], [PM.sub.2.5], and UFP. The [PM.sub.2.5] sourcespecific analysis showed a positive association for the vehicular source but not for the crustal source. Although the effects of PNC and LDSA were similar in magnitude, two-pollutant and residual-based models suggested that LDSA may be a better marker for the health relevance of UFP. http://dx.doi.org/10.1289/EHP161, Introduction Epidemiological and experimental research has provided sufficient evidence for a causal effect of ambient air pollution [mainly particulate matter (PM)] on cardiovascular mortality and morbidity (Brook et al. 2010). [...]

Published
2016
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