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1. Poster display IV experimental and instrumentation

Author

Masoli, O. Osvaldo, Redruello, M., Ogresta, F., Collaud, C., Koslowski, P., Baliño, N. Perez, Eleta, M., Arce, P., Vidal, L., Kardash, O., Maroz-Vadalajskaya, N. Natalia, Vanhove, C. Christian, Lahoutte, T., Defrise, M., Andreyev, A., Bossuyt, A., Franken, P. R., Franken, P. R. Philippe, Lahoutte, T., Maskali, F., Vanhove, C., Nloga, J., Tran, N., Marie, P. Y., Peix, A. Amalia, Garcia-Barreto, D., Ponce, F., Cabrera, L. O., Valiente, J., Tornes, F., Guerrero, I., Heres, F., Garcia, E. J., Cabale, B., Bindslev, L. Lene, Bisgaard, K. B. Kirsten, Haack-Soerensen, M. H. S. Mandana, Mortensen, S. M. Steen, Kragh, L. K. Linda, Kjaer, A. K. Andreas, Kastrup, J. K. Jens, Hesse, B. H. Birger, Aboul-Enein, F. Fatma, Battah, A., Fattah, A. Abdel, Atty, A. Abdel, Allam, A., Riou, L. Laurent, Broisat, A., Ghezzi, C., Lartizien, C., Berthonneche, C., Toufektsian, M. C., Maitrejean, S., Janier, M., Vanzetto, G., Fagret, D., Rouzet, F. Francois, Daou, D., Lebtahi, R., Frank, R., Leenhardt, A., Slama, M., Guludec, D. Le, Sarda-Mantel, L. Laure, Michel, J. B., Rouzet, F., Martet, G., Meulemans, A., Vrigneaud, J. M., Guludec, D. Le, Daou, D. Doumit, Coaguila, C., Benada, A., Razzouk, M., Idy-Peretti, I., Guludec, D. Le, Vilain, D., Lebtahi, R., Guludec, D. Le, Stegger, L. Lars, Schäfers, K., Flögel, U., Schrader, J., Schober, O., Levkau, B., Schäfers, M., Kies, P. Peter, Wichter, T., Schäfers, K. P., Schäfers, M., Wielepp, J. P. Peter, Baller, D., Pulawski, E., Weise, R., Fricke, E., Horstkotte, D., Burchert, W., Eckert, S., Dongas, A., Horstkotte, D., Burchert, W., Nekolla, S. G. Stephan, Martinez, M. J., Howe, W., Kehren, F., Ziegler, S. I., Vassiliadis, I. Ioannis, Souretis, G., Komporozos, C., Fountos, A., Papademetriou, A., Spanos, A., Antoniou, A., Strembelas, P., Moralidis, E. Efstratios, Arsos, G., Boundas, D., Georga, S., Karatzas, N., Karakatsanis, K., Prassopoulos, V. Vassilios, Parthenakis, F., Patrianakos, A., Koukouraki, S., Velidaki, A., Karkavitsas, N., Vardas, P., Velidaki, A. Antigone, Perisinakis, K., Koukouraki, S., Koutsikos, J., Prassopoulos, V., Vardas, P., Karkavitsas, N., Sundaraiya, S. Sumati, Sumati, S., Sambhasivam, KA., David, S., Zakavi, S. R. Seyed Rasoul, Kakhki, V. R. Dabagh, Jabari, H., Zingerman, B., Bendayan, D., Sagie, A., Solodky, A., Mats, I., Shapira, Y., Kremer, M. R., Zafrir, N. Nili, Rimini, M. L. Maria Luisa De, Catalano, M., Bonzani, G., Scalzone, A., Merenda, R., Monteforte, I., Monda, V., Muto, P., Carboni, G. P. Gian Piero, Miglionico, M., Tavolozza, M., Marcassa, C. Claudio, Campini, R., Calza, P., Giannuzzi, P., Eleuteri, E., Marcassa, C. Claudio, Campini, R., Scapellato, F., Temporelli, P. L., Giannuzzi, P., Pellegrino, T., Storto, G., Sorrentino, A. R., Silvestri, A., Filardi, P. Perrone, Brevetti, G., Cuocolo, A. Alberto, Cho, K. Keiichi, Kumita, S., Seino, K., Nakajo, H., Toba, M., Kumazaki, T., Muramatsu, T. Toshihiro, Yamazaki, T., Seki, K., Kawanami, J., Nakajima, T., Yamada, Y., Suga, T., Matsumoto, K., Nishimura, S., Taki, J. Junichi, Higuchi, T., Kawashima, A., Nakajima, K., Muramori, A., Matsunari, I., Tait, J. F., Vanderheyden, J. L., Strauss, H. W., Tonami, N., Adachi, I. Itaru, Shimomura, H., Kintaka, T., Komori, T., Ogura, Y., Kitaura, Y., Narabayashi, I., Iida, H. Hidehiro, Zeniya, T., Kim, K. M., Watabe, H., Teramoto, N., Yamamichi, Y., Alexanderson, E. Erick, Ricalde, A., Vargas, A., Meave, A., Amigo, M. C., Misko, J., Dziuk, M. Miroslaw, Warczynska, A., Skrobowska, E., Vasconcelos, M. Mariana, Martins, E., Faria, T., Oliveira, A., Pardal, N., Macedo, F., Pereira, J., Rocha-Gonçalves, F., Cantinho, G. Guilhermina, Pena, H., Freire, L., Veiga, A., Gonçalves, P., Godinho, F., Chua, T. Terrance, Lee, C. Y., Keng, F., Ding, Z. P., Koh, T. H., Awamleh, P. Paula, Talavera, P., Torres, V., Balsa, M. A., González, O., Alberca, M. T., Miguel, R., Cosío, F. G., Lomsky, M. Milan, Richter, J., Johansson, L., El-Ali, H., Åström, K., Ljungberg, M., Edenbrandt, L., Hung, G. U. Guang-Uei, Lee, K. W., Chen, C. P., Yang, K. T., Pekindil, G., Sarikaya, A. Ali, Ege, T., Salihoglu, S., Entok, E. Emre, Cavusoglu, Y., Ak, I., Vardareli, E., Timuralp, B., Tout, D. Deborah, Loong, C. Y., Naidoo, V. V., Aswegen, A. Van, Underwood, S. R., Thorley, P. J. Penelope, Goris, M. Michael, ZHU, H. J., Clements, I. P. Ian, Mullan, B. P., O’Connor, M. K., Breen, J. F., McGregor, C. G. A., Liu, Y. H. Yi-Hwa, Li, S., Bourke, B., Weyman, C., Sinusas, A. J., Ramakrishna, G. Gautam, Miller, T. D., O’Connor, M. K., Gibbons, R. J., Tsatkin, V., Wackers, F. J. T. H., Liu, Y. H. Yi-Hwa, Tsatkin, V., Prior, J. O. John, Facta, A. D., Schindler, T. H., Oxilia-Estigarribia, M. A., Hernandez-Pampaloni, M., Campisi, R., Zhang, X., Bischof-Delaloye, A., Nathan, L., Schelbert, H. R., Gullberg, G. T. Grant, Huesman, R. H., Reutter, B. W., Sitek, A., Veress, A. I., Weiss, J. A., Qi, J., Yang, Y., Gordi, T. Toufigh, Olmsted, A., Lieu, H., and Belardinelli, L.

Published
2005
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2. PET reconstruction with system matrix derived from point source measurements

Author

Panin, V.Y., Kehren, F., Rothfuss, H., Hu, D., Michel, C., and Casey, M.E.

Subjects
Iterative methods (Mathematics) -- Usage, PET imaging -- Usage, PET imaging -- Research, Business, Electronics, Electronics and electrical industries
Abstract

The quality of images reconstructed by statistical iterative methods depends on an accurate model of the relationship between image space and projection space through the system matrix. The elements of a system matrix on the HiRez scanner from CPS Innovations were acquired by positioning a point source at different positions in the scanner field of view. Then, a whole system matrix was derived by processing the responses in projection space. Such responses included both geometrical and detection physics components of the system matrix. The response was parameterized to correct for point source location, smooth projection noise and the whole system matrix was derived. The model accounts for axial compression (span) used on the scanner. The projection operator for iterative reconstruction was constructed using the estimated response parameters. Computer-generated and acquired data were used to compare reconstruction obtained by the HiRez standard software and that produced by better modeling. Results showed that better resolution and noise property can be achieved with the modeled system matrix. Index Terms--Iterative reconstruction, PET, PSF modeling.

Published
2006

3. Evaluation of the TierPET system

Author

Weber, S., Herzog, H., Cremer, M., Engels, R., Hamacher, K., Kehren, F., Muehlensiepen, H., Ploux, L., Reinartz, R., Reinhart, P., Rongen, F., Sonnenberg, F., Coenen, H.H., and Halling, H.

Subjects
Medical imaging equipment -- Design and construction, PET imaging -- Equipment and supplies, Business, Electronics, Electronics and electrical industries
Abstract

The TierPET system, a high resolution 3D positron emission tomograph, has been developed to perform small animal positron emission tomography (PET) studies. High resolution PET opens the possibility to perform animal trials without the need for vivisection. This reduces the number of animals and the costs for such experiments, for example concerning the development of new radiopharmaceuticals. The scanner uses two orthogonal pairs of detectors consisting of arrays of small individual YAP crystals coupled to position sensitive photomultipliers. The center-detector distance may be varied to improve either sensitivity or spatial resolution. The spatial resolution of the scanner is 2.1 mm.

Published
1999

5. Poster display IV experimental and instrumentation

Author

Masoli, O., Redruello, M., Ogresta, F., Collaud, C., Koslowski, P., Baliño, N., Eleta, M., Arce, P., Vidal, L., Kardash, O., Maroz-Vadalajskaya, N., Vanhove, C., Lahoutte, T., Defrise, M., Andreyev, A., Bossuyt, A., Franken, P., Maskali, F., Nloga, J., Tran, N., Marie, P., Peix, A., Garcia-Barreto, D., Ponce, F., Cabrera, L., Valiente, J., Tornes, F., Guerrero, I., Heres, F., Garcia, E., Cabale, B., Bindslev, L., Bisgaard, K., Haack-Soerensen, M., Mortensen, S., Kragh, L., Kjaer, A., Kastrup, J., Hesse, B., Aboul-Enein, F., Battah, A., Fattah, A., Atty, A., Allam, A., Riou, L., Broisat, A., Ghezzi, C., Lartizien, C., Berthonneche, C., Toufektsian, M., Maitrejean, S., Janier, M., Vanzetto, G., Fagret, D., Rouzet, F., Daou, D., Lebtahi, R., Frank, R., Leenhardt, A., Slama, M., Guludec, D., Sarda-Mantel, L., Michel, J., Martet, G., Meulemans, A., Vrigneaud, J., Coaguila, C., Benada, A., Razzouk, M., Idy-Peretti, I., Vilain, D., Stegger, L., Schäfers, K., Flögel, U., Schrader, J., Schober, O., Levkau, B., Schäfers, M., Kies, P., Wichter, T., Wielepp, J., Baller, D., Pulawski, E., Weise, R., Fricke, E., Horstkotte, D., Burchert, W., Eckert, S., Dongas, A., Nekolla, S., Martinez, M., Howe, W., Kehren, F., Ziegler, S., Vassiliadis, I., Souretis, G., Komporozos, C., Fountos, A., Papademetriou, A., Spanos, A., Antoniou, A., Strembelas, P., Moralidis, E., Arsos, G., Boundas, D., Georga, S., Karatzas, N., Karakatsanis, K., Prassopoulos, V., Parthenakis, F., Patrianakos, A., Koukouraki, S., Velidaki, A., Karkavitsas, N., Vardas, P., Perisinakis, K., Koutsikos, J., Sundaraiya, S., Sumati, S., Sambhasivam, KA, David, S., Zakavi, S., Kakhki, V., Jabari, H., Zingerman, B., Bendayan, D., Sagie, A., Solodky, A., Mats, I., Shapira, Y., Kremer, M., Zafrir, N., Rimini, M., Catalano, M., Bonzani, G., Scalzone, A., Merenda, R., Monteforte, I., Monda, V., Muto, P., Carboni, G., Miglionico, M., Tavolozza, M., Marcassa, C., Campini, R., Calza, P., Giannuzzi, P., Eleuteri, E., Scapellato, F., Temporelli, P., Pellegrino, T., Storto, G., Sorrentino, A., Silvestri, A., Filardi, P., Brevetti, G., Cuocolo, A., Cho, K., Kumita, S., Seino, K., Nakajo, H., Toba, M., Kumazaki, T., Muramatsu, T., Yamazaki, T., Seki, K., Kawanami, J., Nakajima, T., Yamada, Y., Suga, T., Matsumoto, K., Nishimura, S., Taki, J., Higuchi, T., Kawashima, A., Nakajima, K., Muramori, A., Matsunari, I., Tait, J., Vanderheyden, J., Strauss, H., Tonami, N., Adachi, I., Shimomura, H., Kintaka, T., Komori, T., Ogura, Y., Kitaura, Y., Narabayashi, I., Iida, H., Zeniya, T., Kim, K., Watabe, H., Teramoto, N., Yamamichi, Y., Alexanderson, E., Ricalde, A., Vargas, A., Meave, A., Amigo, M., Misko, J., Dziuk, M., Warczynska, A., Skrobowska, E., Vasconcelos, M., Martins, E., Faria, T., Oliveira, A., Pardal, N., Macedo, F., Pereira, J., Rocha-Gonçalves, F., Cantinho, G., Pena, H., Freire, L., Veiga, A., Gonçalves, P., Godinho, F., Chua, T., Lee, C., Keng, F., Ding, Z., Koh, T., Awamleh, P., Talavera, P., Torres, V., Balsa, M., González, O., Alberca, M., Miguel, R., Cosío, F., Lomsky, M., Richter, J., Johansson, L., El-Ali, H., Åström, K., Ljungberg, M., Edenbrandt, L., Hung, G., Lee, K., Chen, C., Yang, K., Pekindil, G., Sarikaya, A., Ege, T., Salihoglu, S., Entok, E., Cavusoglu, Y., Ak, I., Vardareli, E., Timuralp, B., Tout, D., Loong, C., Naidoo, V., Aswegen, A., Underwood, S., Thorley, P., Goris, M., ZHU, H., Clements, I., Mullan, B., O'Connor, M., Breen, J., McGregor, C., Liu, Y., Li, S., Bourke, B., Weyman, C., Sinusas, A., Ramakrishna, G., Miller, T., Gibbons, R., Tsatkin, V., Wackers, F., Prior, J., Facta, A., Schindler, T., Oxilia-Estigarribia, M., Hernandez-Pampaloni, M., Campisi, R., Zhang, X., Bischof-Delaloye, A., Nathan, L., Schelbert, H., Gullberg, G., Huesman, R., Reutter, B., Sitek, A., Veress, A., Weiss, J., Qi, J., Yang, Y., Gordi, T., Olmsted, A., Lieu, H., Belardinelli, L., Masoli, O., Redruello, M., Ogresta, F., Collaud, C., Koslowski, P., Baliño, N., Eleta, M., Arce, P., Vidal, L., Kardash, O., Maroz-Vadalajskaya, N., Vanhove, C., Lahoutte, T., Defrise, M., Andreyev, A., Bossuyt, A., Franken, P., Maskali, F., Nloga, J., Tran, N., Marie, P., Peix, A., Garcia-Barreto, D., Ponce, F., Cabrera, L., Valiente, J., Tornes, F., Guerrero, I., Heres, F., Garcia, E., Cabale, B., Bindslev, L., Bisgaard, K., Haack-Soerensen, M., Mortensen, S., Kragh, L., Kjaer, A., Kastrup, J., Hesse, B., Aboul-Enein, F., Battah, A., Fattah, A., Atty, A., Allam, A., Riou, L., Broisat, A., Ghezzi, C., Lartizien, C., Berthonneche, C., Toufektsian, M., Maitrejean, S., Janier, M., Vanzetto, G., Fagret, D., Rouzet, F., Daou, D., Lebtahi, R., Frank, R., Leenhardt, A., Slama, M., Guludec, D., Sarda-Mantel, L., Michel, J., Martet, G., Meulemans, A., Vrigneaud, J., Coaguila, C., Benada, A., Razzouk, M., Idy-Peretti, I., Vilain, D., Stegger, L., Schäfers, K., Flögel, U., Schrader, J., Schober, O., Levkau, B., Schäfers, M., Kies, P., Wichter, T., Wielepp, J., Baller, D., Pulawski, E., Weise, R., Fricke, E., Horstkotte, D., Burchert, W., Eckert, S., Dongas, A., Nekolla, S., Martinez, M., Howe, W., Kehren, F., Ziegler, S., Vassiliadis, I., Souretis, G., Komporozos, C., Fountos, A., Papademetriou, A., Spanos, A., Antoniou, A., Strembelas, P., Moralidis, E., Arsos, G., Boundas, D., Georga, S., Karatzas, N., Karakatsanis, K., Prassopoulos, V., Parthenakis, F., Patrianakos, A., Koukouraki, S., Velidaki, A., Karkavitsas, N., Vardas, P., Perisinakis, K., Koutsikos, J., Sundaraiya, S., Sumati, S., Sambhasivam, KA, David, S., Zakavi, S., Kakhki, V., Jabari, H., Zingerman, B., Bendayan, D., Sagie, A., Solodky, A., Mats, I., Shapira, Y., Kremer, M., Zafrir, N., Rimini, M., Catalano, M., Bonzani, G., Scalzone, A., Merenda, R., Monteforte, I., Monda, V., Muto, P., Carboni, G., Miglionico, M., Tavolozza, M., Marcassa, C., Campini, R., Calza, P., Giannuzzi, P., Eleuteri, E., Scapellato, F., Temporelli, P., Pellegrino, T., Storto, G., Sorrentino, A., Silvestri, A., Filardi, P., Brevetti, G., Cuocolo, A., Cho, K., Kumita, S., Seino, K., Nakajo, H., Toba, M., Kumazaki, T., Muramatsu, T., Yamazaki, T., Seki, K., Kawanami, J., Nakajima, T., Yamada, Y., Suga, T., Matsumoto, K., Nishimura, S., Taki, J., Higuchi, T., Kawashima, A., Nakajima, K., Muramori, A., Matsunari, I., Tait, J., Vanderheyden, J., Strauss, H., Tonami, N., Adachi, I., Shimomura, H., Kintaka, T., Komori, T., Ogura, Y., Kitaura, Y., Narabayashi, I., Iida, H., Zeniya, T., Kim, K., Watabe, H., Teramoto, N., Yamamichi, Y., Alexanderson, E., Ricalde, A., Vargas, A., Meave, A., Amigo, M., Misko, J., Dziuk, M., Warczynska, A., Skrobowska, E., Vasconcelos, M., Martins, E., Faria, T., Oliveira, A., Pardal, N., Macedo, F., Pereira, J., Rocha-Gonçalves, F., Cantinho, G., Pena, H., Freire, L., Veiga, A., Gonçalves, P., Godinho, F., Chua, T., Lee, C., Keng, F., Ding, Z., Koh, T., Awamleh, P., Talavera, P., Torres, V., Balsa, M., González, O., Alberca, M., Miguel, R., Cosío, F., Lomsky, M., Richter, J., Johansson, L., El-Ali, H., Åström, K., Ljungberg, M., Edenbrandt, L., Hung, G., Lee, K., Chen, C., Yang, K., Pekindil, G., Sarikaya, A., Ege, T., Salihoglu, S., Entok, E., Cavusoglu, Y., Ak, I., Vardareli, E., Timuralp, B., Tout, D., Loong, C., Naidoo, V., Aswegen, A., Underwood, S., Thorley, P., Goris, M., ZHU, H., Clements, I., Mullan, B., O'Connor, M., Breen, J., McGregor, C., Liu, Y., Li, S., Bourke, B., Weyman, C., Sinusas, A., Ramakrishna, G., Miller, T., Gibbons, R., Tsatkin, V., Wackers, F., Prior, J., Facta, A., Schindler, T., Oxilia-Estigarribia, M., Hernandez-Pampaloni, M., Campisi, R., Zhang, X., Bischof-Delaloye, A., Nathan, L., Schelbert, H., Gullberg, G., Huesman, R., Reutter, B., Sitek, A., Veress, A., Weiss, J., Qi, J., Yang, Y., Gordi, T., Olmsted, A., Lieu, H., and Belardinelli, L.

Published
2018

6. Recent Results of the TierPET Scanner

Author

Weber, S., Bauer, A., Herzog, H., Kehren, F., Muhlensiepen, H., Vogelbruch, J., Coenen, H. H., Zilles, K., and Halling, H.

Subjects
PET imaging -- Research, Imaging systems -- Research, Crystals -- Usage, Detectors -- Research, Business, Electronics, Electronics and electrical industries
Abstract

At the Forschungszentrum Julich a high resolution positron emission tomograph (TierPET) for imaging small laboratory animals, especially rats, has been constructed. The scanner is based on arrays of YAP crystals. As a special feature the detector distances can be varied continuously from 16 to 58 cm. Due to the variable detector distances the performance of the scanner has to be evaluated in various configurations. Special attention was paid to dedicated data acquisition protocols and adequate applications with regard to the system sensitivity.

Published
2000

7. Left-right asymmetry of striatal dopamine D2 receptors

Author

Meyer W, Rolf Larisch, Hans-Wilhelm Müller-Gärtner, Kehren F, Henning Vosberg, and Ansgar Klimke

Subjects
Adult, Male, Striatal dopamine, Aging, medicine.medical_specialty, Pyrrolidines, media_common.quotation_subject, Binding ratio, Asymmetry, Lateralization of brain function, Iodine Radioisotopes, Cerebellum, Internal medicine, Dopamine receptor D2, medicine, Single Photon Emission Tomography, Humans, Radiology, Nuclear Medicine and imaging, Receptor, Aged, media_common, Aged, 80 and over, Tomography, Emission-Computed, Single-Photon, Receptors, Dopamine D2, Chemistry, business.industry, General Medicine, Middle Aged, Corpus Striatum, Endocrinology, Benzamides, Laterality, Female, Nuclear medicine, business
Abstract

Brain functions may be lateralized to the right or the left hemisphere. However, the biochemical characteristics accompanying these functions are largely unknown. To test possible lateralization of striatal dopamine D 2 receptors, we examined 18 volunteers using 123 I-iodobenzamide and single photon emission tomography. The striatum-to-cerebellum D 2 binding ratio was 1.93 ± 0.22 (mean ± s.D.) on the right side and 1.85 ± 0.19 on the left side. In 14 subjects, D 2 binding was higher in the right compared to the left striatum (P < 0.05). These results are supported by a meta-analysis performed on 15 studies reported in the literature. We conclude that side differences of striatal dopamine D 2 receptors exist. We propose that motor activity could be responsible for our findings.

Published
1998

13. SPMD cluster-based parallel 3D OSEM

Author

Jones, J.P., primary, Jones, W.F., additional, Kehren, F., additional, Newport, D.F., additional, Reed, J.H., additional, Lenox, M.W., additional, Baker, K., additional, Byars, L.G., additional, Michel, C., additional, and Casey, M.E., additional

Published
2003
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21. Leftright asymmetry of striatal dopamine D2receptors

Author

LARISCH, R., MEYER, W., KLIMKE, A., KEHREN, F., VOSBERG, H., and MULLER-GARTNER, H. -W.

Abstract

Brain functions may be lateralized to the right or the left hemisphere. However, the biochemical characteristics accompanying these functions are largely unknown. To test possible lateralization of striatal dopamine D2receptors, we examined 18 volunteers using 123I-ioc1obenzamide and single photon emission tomography. The striatum-to-cerebellum D2binding ratio was 1.93 ± 0.22 (mean ±S.D.) on the right side and 1.85 ± 0.19 on the left side. In 14 subjects, D, binding was higher in the right compared to the left striatum (P < 0.05). These results are supported by a meta-analysis performed on 15 studies reported in the literature. We conclude that side differences of striatal dopamine D2receptors exist. We propose that motor activity could be responsible for our findings. (© 1998 Lippincott Williams & Wilkins)

Published
1998

22. Poster display IV experimental and instrumentation

Author

Masoli, O., Redruello, M., Ogresta, F., Collaud, C., Koslowski, P., Baliño, N., Eleta, M., Arce, P., Vidal, L., Kardash, O., Maroz-Vadalajskaya, N., Vanhove, C., Lahoutte, T., Defrise, M., Andreyev, A., Bossuyt, A., Franken, P., Maskali, F., Nloga, J., Tran, N., Marie, P., Peix, A., Garcia-Barreto, D., Ponce, F., Cabrera, L., Valiente, J., Tornes, F., Guerrero, I., Heres, F., Garcia, E., Cabale, B., Bindslev, L., Bisgaard, K., Haack-Soerensen, M., Mortensen, S., Kragh, L., Kjaer, A., Kastrup, J., Hesse, B., Aboul-Enein, F., Battah, A., Fattah, A., Atty, A., Allam, A., Riou, L., Broisat, A., Ghezzi, C., Lartizien, C., Berthonneche, C., Toufektsian, M., Maitrejean, S., Janier, M., Vanzetto, G., Fagret, D., Rouzet, F., Daou, D., Lebtahi, R., Frank, R., Leenhardt, A., Slama, M., Guludec, D., Sarda-Mantel, L., Michel, J., Martet, G., Meulemans, A., Vrigneaud, J., Coaguila, C., Benada, A., Razzouk, M., Idy-Peretti, I., Vilain, D., Stegger, L., Schäfers, K., Flögel, U., Schrader, J., Schober, O., Levkau, B., Schäfers, M., Kies, P., Wichter, T., Wielepp, J., Baller, D., Pulawski, E., Weise, R., Fricke, E., Horstkotte, D., Burchert, W., Eckert, S., Dongas, A., Nekolla, S., Martinez, M., Howe, W., Kehren, F., Ziegler, S., Vassiliadis, I., Souretis, G., Komporozos, C., Fountos, A., Papademetriou, A., Spanos, A., Antoniou, A., Strembelas, P., Moralidis, E., Arsos, G., Boundas, D., Georga, S., Karatzas, N., Karakatsanis, K., Prassopoulos, V., Parthenakis, F., Patrianakos, A., Koukouraki, S., Velidaki, A., Karkavitsas, N., Vardas, P., Perisinakis, K., Koutsikos, J., Sundaraiya, S., Sumati, S., Sambhasivam, KA, David, S., Zakavi, S., Kakhki, V., Jabari, H., Zingerman, B., Bendayan, D., Sagie, A., Solodky, A., Mats, I., Shapira, Y., Kremer, M., Zafrir, N., Rimini, M., Catalano, M., Bonzani, G., Scalzone, A., Merenda, R., Monteforte, I., Monda, V., Muto, P., Carboni, G., Miglionico, M., Tavolozza, M., Marcassa, C., Campini, R., Calza, P., Giannuzzi, P., Eleuteri, E., Scapellato, F., Temporelli, P., Pellegrino, T., Storto, G., Sorrentino, A., Silvestri, A., Filardi, P., Brevetti, G., Cuocolo, A., Cho, K., Kumita, S., Seino, K., Nakajo, H., Toba, M., Kumazaki, T., Muramatsu, T., Yamazaki, T., Seki, K., Kawanami, J., Nakajima, T., Yamada, Y., Suga, T., Matsumoto, K., Nishimura, S., Taki, J., Higuchi, T., Kawashima, A., Nakajima, K., Muramori, A., Matsunari, I., Tait, J., Vanderheyden, J., Strauss, H., Tonami, N., Adachi, I., Shimomura, H., Kintaka, T., Komori, T., Ogura, Y., Kitaura, Y., Narabayashi, I., Iida, H., Zeniya, T., Kim, K., Watabe, H., Teramoto, N., Yamamichi, Y., Alexanderson, E., Ricalde, A., Vargas, A., Meave, A., Amigo, M., Misko, J., Dziuk, M., Warczynska, A., Skrobowska, E., Vasconcelos, M., Martins, E., Faria, T., Oliveira, A., Pardal, N., Macedo, F., Pereira, J., Rocha-Gonçalves, F., Cantinho, G., Pena, H., Freire, L., Veiga, A., Gonçalves, P., Godinho, F., Chua, T., Lee, C., Keng, F., Ding, Z., Koh, T., Awamleh, P., Talavera, P., Torres, V., Balsa, M., González, O., Alberca, M., Miguel, R., Cosío, F., Lomsky, M., Richter, J., Johansson, L., El-Ali, H., Åström, K., Ljungberg, M., Edenbrandt, L., Hung, G., Lee, K., Chen, C., Yang, K., Pekindil, G., Sarikaya, A., Ege, T., Salihoglu, S., Entok, E., Cavusoglu, Y., Ak, I., Vardareli, E., Timuralp, B., Tout, D., Loong, C., Naidoo, V., Aswegen, A., Underwood, S., Thorley, P., Goris, M., ZHU, H., Clements, I., Mullan, B., O'Connor, M., Breen, J., McGregor, C., Liu, Y., Li, S., Bourke, B., Weyman, C., Sinusas, A., Ramakrishna, G., Miller, T., Gibbons, R., Tsatkin, V., Wackers, F., Prior, J., Facta, A., Schindler, T., Oxilia-Estigarribia, M., Hernandez-Pampaloni, M., Campisi, R., Zhang, X., Bischof-Delaloye, A., Nathan, L., Schelbert, H., Gullberg, G., Huesman, R., Reutter, B., Sitek, A., Veress, A., Weiss, J., Qi, J., Yang, Y., Gordi, T., Olmsted, A., Lieu, H., Belardinelli, L., Masoli, O., Redruello, M., Ogresta, F., Collaud, C., Koslowski, P., Baliño, N., Eleta, M., Arce, P., Vidal, L., Kardash, O., Maroz-Vadalajskaya, N., Vanhove, C., Lahoutte, T., Defrise, M., Andreyev, A., Bossuyt, A., Franken, P., Maskali, F., Nloga, J., Tran, N., Marie, P., Peix, A., Garcia-Barreto, D., Ponce, F., Cabrera, L., Valiente, J., Tornes, F., Guerrero, I., Heres, F., Garcia, E., Cabale, B., Bindslev, L., Bisgaard, K., Haack-Soerensen, M., Mortensen, S., Kragh, L., Kjaer, A., Kastrup, J., Hesse, B., Aboul-Enein, F., Battah, A., Fattah, A., Atty, A., Allam, A., Riou, L., Broisat, A., Ghezzi, C., Lartizien, C., Berthonneche, C., Toufektsian, M., Maitrejean, S., Janier, M., Vanzetto, G., Fagret, D., Rouzet, F., Daou, D., Lebtahi, R., Frank, R., Leenhardt, A., Slama, M., Guludec, D., Sarda-Mantel, L., Michel, J., Martet, G., Meulemans, A., Vrigneaud, J., Coaguila, C., Benada, A., Razzouk, M., Idy-Peretti, I., Vilain, D., Stegger, L., Schäfers, K., Flögel, U., Schrader, J., Schober, O., Levkau, B., Schäfers, M., Kies, P., Wichter, T., Wielepp, J., Baller, D., Pulawski, E., Weise, R., Fricke, E., Horstkotte, D., Burchert, W., Eckert, S., Dongas, A., Nekolla, S., Martinez, M., Howe, W., Kehren, F., Ziegler, S., Vassiliadis, I., Souretis, G., Komporozos, C., Fountos, A., Papademetriou, A., Spanos, A., Antoniou, A., Strembelas, P., Moralidis, E., Arsos, G., Boundas, D., Georga, S., Karatzas, N., Karakatsanis, K., Prassopoulos, V., Parthenakis, F., Patrianakos, A., Koukouraki, S., Velidaki, A., Karkavitsas, N., Vardas, P., Perisinakis, K., Koutsikos, J., Sundaraiya, S., Sumati, S., Sambhasivam, KA, David, S., Zakavi, S., Kakhki, V., Jabari, H., Zingerman, B., Bendayan, D., Sagie, A., Solodky, A., Mats, I., Shapira, Y., Kremer, M., Zafrir, N., Rimini, M., Catalano, M., Bonzani, G., Scalzone, A., Merenda, R., Monteforte, I., Monda, V., Muto, P., Carboni, G., Miglionico, M., Tavolozza, M., Marcassa, C., Campini, R., Calza, P., Giannuzzi, P., Eleuteri, E., Scapellato, F., Temporelli, P., Pellegrino, T., Storto, G., Sorrentino, A., Silvestri, A., Filardi, P., Brevetti, G., Cuocolo, A., Cho, K., Kumita, S., Seino, K., Nakajo, H., Toba, M., Kumazaki, T., Muramatsu, T., Yamazaki, T., Seki, K., Kawanami, J., Nakajima, T., Yamada, Y., Suga, T., Matsumoto, K., Nishimura, S., Taki, J., Higuchi, T., Kawashima, A., Nakajima, K., Muramori, A., Matsunari, I., Tait, J., Vanderheyden, J., Strauss, H., Tonami, N., Adachi, I., Shimomura, H., Kintaka, T., Komori, T., Ogura, Y., Kitaura, Y., Narabayashi, I., Iida, H., Zeniya, T., Kim, K., Watabe, H., Teramoto, N., Yamamichi, Y., Alexanderson, E., Ricalde, A., Vargas, A., Meave, A., Amigo, M., Misko, J., Dziuk, M., Warczynska, A., Skrobowska, E., Vasconcelos, M., Martins, E., Faria, T., Oliveira, A., Pardal, N., Macedo, F., Pereira, J., Rocha-Gonçalves, F., Cantinho, G., Pena, H., Freire, L., Veiga, A., Gonçalves, P., Godinho, F., Chua, T., Lee, C., Keng, F., Ding, Z., Koh, T., Awamleh, P., Talavera, P., Torres, V., Balsa, M., González, O., Alberca, M., Miguel, R., Cosío, F., Lomsky, M., Richter, J., Johansson, L., El-Ali, H., Åström, K., Ljungberg, M., Edenbrandt, L., Hung, G., Lee, K., Chen, C., Yang, K., Pekindil, G., Sarikaya, A., Ege, T., Salihoglu, S., Entok, E., Cavusoglu, Y., Ak, I., Vardareli, E., Timuralp, B., Tout, D., Loong, C., Naidoo, V., Aswegen, A., Underwood, S., Thorley, P., Goris, M., ZHU, H., Clements, I., Mullan, B., O'Connor, M., Breen, J., McGregor, C., Liu, Y., Li, S., Bourke, B., Weyman, C., Sinusas, A., Ramakrishna, G., Miller, T., Gibbons, R., Tsatkin, V., Wackers, F., Prior, J., Facta, A., Schindler, T., Oxilia-Estigarribia, M., Hernandez-Pampaloni, M., Campisi, R., Zhang, X., Bischof-Delaloye, A., Nathan, L., Schelbert, H., Gullberg, G., Huesman, R., Reutter, B., Sitek, A., Veress, A., Weiss, J., Qi, J., Yang, Y., Gordi, T., Olmsted, A., Lieu, H., and Belardinelli, L.

23. SPMD cluster-based parallel 3D OSEM

Author

Jones, J.P., primary, Jones, W.F., additional, Kehren, F., additional, Newport, D.F., additional, Reed, J.H., additional, Lenox, M.W., additional, Byars, L.G., additional, Baker, K., additional, Michel, C., additional, and Casey, M.E., additional

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26. Evaluation of the TierPET system

Author

Weber, S., primary, Herzog, H., additional, Coenen, H.H., additional, Cremer, M., additional, Engels, R., additional, Hamacher, K., additional, Kehren, F., additional, Muehlensiepen, H., additional, Ploux, L., additional, Reinartz, R., additional, Reinhart, P., additional, Rongen, F., additional, Sonnenberg, F., additional, and Halling, H., additional

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33. Completion of a truncated attenuation image from the attenuated PET emission data.

Author

Nuyts J, Bal G, Kehren F, Fenchel M, Michel C, and Watson C

Subjects
Humans, Reproducibility of Results, Sensitivity and Specificity, Algorithms, Image Enhancement methods, Image Interpretation, Computer-Assisted methods, Positron-Emission Tomography methods
Abstract

Positron emission tomographs (PETs) are currently almost exclusively designed as hybrid systems. The current standard is the PET/CT combination, while prototype PET/MRI systems are being studied by several research groups. One problem in these systems is that the transaxial field-of-view of the second system is smaller than that of the PET camera and does not provide complete attenuation data. Because this second system provides the image for PET attenuation and scatter correction, the smaller FOV causes truncation of the attenuation map, producing bias in the attenuation corrected activity image. In this paper, we propose a maximum-a-posteriori algorithm for estimating the missing part of the attenuation map from the PET emission data. The method is evaluated on five artificially truncated 18F-FDGPET/CT studies, where it reduced the error on the reconstructed PET activities from 20% to less than 7%. The results on a PET/MRI patient study with 18F-FDG are presented as well.

Published
2013
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34. First experimental results of time-of-flight reconstruction on an LSO PET scanner.

Author

Conti M, Bendriem B, Casey M, Chen M, Kehren F, Michel C, and Panin V

Subjects
Humans, Image Interpretation, Computer-Assisted, Positron-Emission Tomography instrumentation, Radiography, Algorithms, Liver diagnostic imaging, Lung diagnostic imaging, Phantoms, Imaging, Positron-Emission Tomography methods
Abstract

Time-of-flight (TOF) positron emission tomography (PET) was studied and preliminarily developed in the 1980s, but the lack of a scintillator able to deliver at the same time proper time resolution and stopping power has prevented this technique from becoming widespread and commercially available. With the introduction of LSO in PET, TOF is now a feasible option. TOF reconstruction has been implemented in the CPS Hi-Rez PET scanner, both with 2D filtered-back-projection (FBP2D) and 3D ordered subset expectation maximization (OSEM3D). A new procedure has been introduced in the time alignment to compensate for the limited digital time resolution of the present electronics. A preliminary version of scatter correction for TOF has been devised and is presented. The measured time resolution of 1.2 ns (FWHM) allowed for a signal-to-noise ratio increase of about 50% in phantoms of about 40 cm transaxial size, or a gain larger than 2 in noise equivalent counts (NEC). TOF reconstruction has shown the expected improvement in SNR, both in simulation and experimental data. First experimental results show two improvements of TOF reconstruction over conventional (non-TOF) reconstruction: a lower noise level and a better capability to resolve structures deep inside large objects.

Published
2005
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35. Application of discrete data consistency conditions for selecting regularization parameters in PET attenuation map reconstruction.

Author

Panin VY, Kehren F, Hamill JJ, and Michel C

Subjects
Humans, Information Storage and Retrieval methods, Phantoms, Imaging, Positron-Emission Tomography instrumentation, Positron-Emission Tomography standards, Reproducibility of Results, Sample Size, Scattering, Radiation, Sensitivity and Specificity, Subtraction Technique, Whole-Body Counting methods, Algorithms, Image Interpretation, Computer-Assisted methods, Imaging, Three-Dimensional methods, Numerical Analysis, Computer-Assisted, Positron-Emission Tomography methods, Radiographic Image Enhancement methods, Signal Processing, Computer-Assisted
Abstract

Simultaneous emission and transmission measurement is appealing in PET due to the matching of geometrical conditions between emission and transmission and reduced acquisition time for the study. A potential problem remains: when transmission statistics are low, attenuation correction could be very noisy. Although noise in the attenuation map can be controlled through regularization during statistical reconstruction, the selection of regularization parameters is usually empirical. In this paper, we investigate the use of discrete data consistency conditions (DDCC) to optimally select one or two regularization parameters. The advantages of the method are that the reconstructed attenuation map is consistent with the emission data and that it accounts for particularity in the emission reconstruction algorithm and acquisition geometry. The methodology is validated using a computer-generated whole-body phantom for both emission and transmission, neglecting random events and scattered radiation. MAP-TR was used for attenuation map reconstruction, while 3D OS-EM is used for estimating the emission image. The estimation of regularization parameters depends on the resolution of the emission image controlled by the number of iterations in OS-EM. The computer simulation shows that, on one hand, DDCC regularized attenuation map reduces propagation of the transmission scan noise to the emission image, while on the other hand DDCC prevents excessive attenuation map smoothing that could result in resolution mismatch artefacts between emission and transmission.

Published
2004
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