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5 results on '"Kehe, Colin R."'

2. Kinetics of Absorption of a New Once-a-Day Formulation of Theophylline in the Presence and Absence of Food

Author

Harrison, Lester I., primary, Mitra, Amit K., additional, Kehe, Colin R., additional, Klinger, Nancy M., additional, Wick, Karen A., additional, Mccarville, Sally E., additional, Cooper, Kathy M., additional, Chang, Shaw F., additional, Roddy, Patrick J., additional, Berge, Steve M., additional, Kisicki, James C., additional, and Dockhorn, Robert, additional

Published
1993
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5. Comparative Absorption of Atropine from a MeteredDose Inhaler and an Intramuscular Injection

Author

Kehe, Colin R., Lasseter, Kenneth C., Miller, Nicholas C., Wick, Karen A., Shamblen, E. Cooper, Ekholm, Bruce P., Sandahl, Jane H., Chang, Shaw F., Goldlust, M. Barry, Kvam, Donald C., and Harrison, Lester I.

Abstract

The inhalation of atropine sulfate from a pressurized metered-dose inhaler was investigated in a nonrandomized four-period rising-dose study. Eight healthy, nonsmoking subjects received 1.7, 3.4, and 5.2 mg of atropine sulfate by inhalation and 1.67 mg of atropine free base (equivalent to 2 mg of atropine sulfate) by intramuscular (i.m.) injection. Serum atropine sulfate concentrations were measured over a 24-h period by gas chromatography/mass spectrometry. Mean serum concentrations increased nonproportionally as the inhaled dose increased. Mean peak concentrations were 4.9, 6.1, and 7.9 ng/ml for the inhaled doses and 8.4 ng/ml for the i.m. dose. Typical anticholinergic effects were seen after all doses.

Published
1992

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