Search

Your search keyword '"Keegan, Sarah"' showing total 188 results
Start Over Author "Keegan, Sarah"
188 results on '"Keegan, Sarah"'

4. CDK-independent role of D-type cyclins in regulating DNA mismatch repair

Author

Rona, Gergely, Miwatani-Minter, Bearach, Zhang, Qingyue, Goldberg, Hailey V., Kerzhnerman, Marc A., Howard, Jesse B., Simoneschi, Daniele, Lane, Ethan, Hobbs, John W., Sassani, Elizabeth, Wang, Andrew A., Keegan, Sarah, Laverty, Daniel J., Piett, Cortt G., Pongor, Lorinc S., Xu, Miranda Li, Andrade, Joshua, Thomas, Anish, Sicinski, Piotr, Askenazi, Manor, Ueberheide, Beatrix, Fenyö, David, Nagel, Zachary D., and Pagano, Michele

Published
2024
Full Text
View/download PDF

5. Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study

Author

Dunning, Jake, Fink, Douglas L, Milligan, Iain D, Luintel, Akish, Rodger, Alison J, Bhagani, Sanjay R, Lamb, Lucy E, Moores, Rachel C, Lee, Simon F K, Brown, Colin S, Hopkins, Susan, Mepham, Stephen, Warren, Simon, Molloy, Aoife, Cropley, Ian, Kew, Alex, Karunaharan, Natasha, Scobie, Antonia, Hart, Jennifer, Irish, Dianne, Haque, Tanzina, Jalal, Hamid, Smith, Robin, Mack, Damien, Barber, Tristan, Burns, Fiona, Miller, Robert, Hamlyn, Eleanor, Simoes, Pedro, Athan, Breda, Abrahamsen, Jennifer, Joyce, Jessica, Taylor, Caroline, Reddecliffe, Sally, Miller, Chloe, Reeve, Brooke, Kingston, Hugh, Crocker-Buque, Tim, Massie, Nicolas, Dhariwal, Ankush, Jayakumar, Angelina, Hammond, Robert, Bramley, Alexandra, Kanitkar, Tanmay, Maynard-Smith, Laura, Gil, Eliza, O'Connor, Cavan, Cocker, Derek, Spicer, Wendy, Lanzman, Marisa, Thacker, Meera, Anorson, Zoe O, Patel, Dharmesh, Williams, Alan, Houlihan, Catherine F, Wakerley, Dominic, Gordon, Claire N, Callaby, Helen, Bailey, Daniel J, Furneaux, Jenna, Bown, Abbie M, Truelove, Elizabeth J, Killip, Marian J, Jackson, David, Beetar-King, Tracy L B, Arnold, Ulrike M V, Strachan, Rhea M, Matthew, Jones, Matthew, Hannah J, Osborne, Jane C, Rampling, Tommy, Vipond, Richard, Gibney, Barry, Owen, Jodie, Bond, Helena, Beynon, Will, Hunter, Michael, McCorry, Louise, Emerson, Carol, Quah, Say, Todd, Suzanne, McCarty, Emma, Walker, Eoin, Feeney, Susan, Curran, Tanya, Li, Kathy, Mullan, JD, Jackson, Kate, Nelson, Peter, Lewis, Kevin, McNicol, Mark, Pratt, Marcus, Smith, Anna, Vos, Erin, Alsalemee, Fahad, O Leary, Daniel, Canny, John, McGinnity, Katherine, Culbert, Carly, McDowell, Conor, McQuillan, Cathy, Jeong, Eunjin, Glass, Lynsey, Dyche, Jessica, McClean, Paula, Stewart, Rebecca, Ursolino, Harold, Perry, Melissa, McCormick, Hannah, Lim, Eleanor Y, Gkrania-Klotsas, Effrossyni, Bracchi, Margherita, Heskin, Joseph, Brown, Nicklas, Juniper, Thomas, Mora-Peris, Borja, Dalla-Pria, Alessia, Mackie, Nicola, Garvey, Lucy, Winston, Alan, Cooke, Graham, Nelson, Mark, Kilbride, Emer, Elbishi, Ala, Kerrigan, William, Silva, Joshua, Gohil, Jesal, Payagala, Sasha, Walters, Yasmin, Smith, Joanna, Goodfellow, Jonathan, Lyons, Kitty, Tung, Hsiu, Patel, Kinjal, Henderson, Merle, Butler, Michael, Peres, Edu, Silva Carvalho, Taiana, Joly, Antoine, Dickinson, Molly, Moore, Luke S P, Mughal, Nabeela, Hughes, Stephen, Chitlangia, Shrada, Viramgana, Priyanka, Byrne, Ruth, Randell, Paul, Strangis, Luigi, Poveda, Nicola, Bovey, Deborah, Richardson, Poppy, Heaslip, Vivian, Higgs, Christopher, Boffito, Marta, Girometti, Nicolo, Whitlock, Gary, Tittle, Victoria, Jones, Rachel, Rayment, Michael, Scott, Christopher, Asboe, David, Pond, Marcus, Muir, David, Rathish, Balram, O'Hara, Geraldine, Abeywickrema, Movin, Bailey, Sarah-Lou, Boyd, Sara E, Da Silva Fontoura, Dayana, Daunt, Anna, Mason, Claire Y, Murphy, Jamie, Naidu, Vasanth V, Patel, Aatish, Pley, Caitlin, Redmore, Ethan, Sharrocks, Katherine, Snell, Luke B, Sundramoorthi, Rohan, Tam, Jerry C H, Brown, Aisling, Douthwaite, Sam, Goodman, Anna, Nebbia, Gaia, Newsholme, William, Price, Nicholas, Shaw, Emily, Salam, Alex, van Nispen tot Pannerden, Claire, Winslow, Helen, Bilinska, Julia, Keegan, Sarah, Coleman, Harry, Doctor, Jessica, Moini, Nasreen, Chilton, Daniella, Haidari, Golaleh, Simons, Rebecca, Kulasegaram, Rajababu, Larbalestier, Nick, Nori, Achyuta, Potter, Jack R, Tuudah, Cecilia, Wade, Paul, Travers, Alexandra, Dunford, Sarah, Greenwood, Joshua, Oledimmah, Georgina, Gyampo, Lesley, SA Pinto, Pedro, Muse, AbdulKadir, Parker, Zoe, Alexander, Charlotte, Khan, Alexander, Ajayi, Medinat, Baltazar, Abigail, Sharella, Davis, Hersi, Nasra, Nguyen, Thuy, Timbo, Rugiatu, Jalloh, Ismail, Bryan, Susan, Clarke, Patricia, Kerr, Marcia, Amedu, Fidelis, BohoBonaba, Maria, Haque, Sarah, Howson, Michelle, Tambilawan, Norbai, Yupanqui Estay, Soledad, Bangura, Hawanatu, Gideon, Tseday, Jerome-oboh, Damilola, Tetteh, Linda, Nwagu, Chioma, Agbaglah, Viwoalo, Narag, Nona, Zaveri, Mahima, Ni Luanaigh, Maedhbh, Keane, Peggy, Peters, Joanna R, Rimmer, Stephanie, Abbara, Aula, Dosekun, Olamide, Bolland, Mhairi, Stafford, Adam, Saleh, Dina, Sheridan, Rhianna, Davies, Ella, Sun, Kristi, Gilchrist, Mark, Kukadia, Priti, Embrahimsa, Muhammed, Chiu, Christopher, Taylor, Lauren, Short, Charlotte, Alagratnam, Jasmini, Jayaweera, Iresh, Gundugola, Kavitha, Payne, Lara V S, Mody, Nisha, Quinn, Killian, Nic Fhogartaigh, Caoimhe, Kaur, Nivenjit, Bholah, Salmaan, Kantha, Kajann, Youngs, Jonathan, Lampejo, Temi, Pitto, Nicholas, Lawrence, David S, Middleditch, Holly, Dominguez-Dominguez, Lourdes, Ratnappuli, Ayoma, Al-Hashimi, Sara, Oliveira, Amelia, Ottaway, Zoe, Mulka, Larissa, Hodgson, Bethany, Lewthwaite, Penny, Neary, Anne M, Downey, Michael R, Lucy, Danielle C, McCallum, Craig I, Beadsworth, Michael, Ratcliffe, Libuse, Fletcher, Tom E, Davies, Gerry, Wong, Nicholas, Aston, Stephen, Wingfield, Thomas E, Blanchard, Thomas, Hine, Paul, Lester, Rebecca, Woolley, Stephen D, Gould, Susie, Smith, Christopher, Abouyannis, Michael, Atomode, Abolaji, Cruise, James, Samual, Merna, Scott, Nicola, Srirathan, Vino, Lewis, Joseph, Richards, Lauren, Cummings, Mary-Ann, Gillan, Emily, Peers, Rebecca, Tickle, Amy, Keating, Grace, Chinyanda, Tendi, Sanchez, Mav, Harrison, Daniel, Hoyle, Metcalfe, Ben, Taylor, Jennifer, Johnson, Nicky, Kelle, Neil, McDowell, Kirsty, Richardson, Ian, Saguidan, Monette, Farmer, Nicky, Gillespie, Angella, Willoughby, Shay, Parker, Samantha, Avulan, Shamseena, Arif, Shazia, Marshall, Suzanne, Carlisle, David, Rezaei, Mohsen, Booth, Angela, Watts, Joanne, Tremarco, Lauren, Jeyanayagam, Priyanga, Ubochi, Odinaka, Vagianos, Daniel, Richardson, Mark, Jarvis, Anthony, Gow, Kyra, Walmsley, Jade, O'keefe, Adam, Smielewska, Anna, Hopkins, Mark, Balane, Fatima, Bradley, Sarah, Corrah, Tumena, Daquiz, Venus, Dugan, Christopher, Elliot, Joshua, Foley, Fiona, Friday, Dawn, Gamit, May, Garner, David, Gokani, Karishma, John, Laurence, Joseph, Deepa, Khan, Nuzhath, Mamuyac, Cherifer, McGregor, Alastair, McSorley, John, Parris, Victoria, Rubinstein, Luciana, Rycroft, Julian, Salinas, Kelcy, Salinas, Jason, Sebatian, Jency, Smith, Melanie, Tejero Garcia, Marina, Ume, Uchenna, Vicentine, Margarete, Wallis, Gabriel, Sturdy, Ann, Whittington, Ashley, Jacobs, Nathan, Johnson, Leann, Bonington, Alec, Uriel, Alison, Ustianowski, Andrew, Dancso, Balazs, Hogan, Celia, van Halsema, Clare, Vilar, F Javier, Devine, Karen, Ajdukiewicz, Katherine, Rajendran, Rajesh, Ghosh, Samit, Riste, Michael, Machin, Nicholas, Babu, Chitra, Ahmad, Shazaad, Obeng, Dorcas, Dave, Farnaz, Conolley, Gavin, Thompson, Joseph, Tickell-Painter, Maya, Chakravorty, Prasun, Pringle, Rachel, Zafar, Mohammad R, Lawrence, Sarah, Sanchez-Gonzalez, Amada, Fernandez, Cristina, Goodwin, Lynsey, Carey, David, Howarth-Maddison, Molly, Moody, Samuel, Upton, Rebecca, Apthorp, Christina, Murray, Charlotte, Salthouse, Kirstie, Nadeem, Sabah, Ridley, Grant, White, Francesca, Brown, Andrew, Lawless, Michael, Mohamed, Mohamed, Mulligan, Robert, Belfield, Amy, Brolly, Jacob, Calderon, Maria, Cheveau, James, Cullinan, Milo, Garrad, Sophie, Griffiths, Will, Ireland, Aidan, Ireland, Peter, Milne, Charlotte, Nwajiugo, Paul, Quartey, John, Ghavami-Kia, Bijan, Duncan, Chris, Evans, Adam, Hunter, Ewan, Price, Ashley, Schmid, Matthias, Schwab, Uli, Taha, Yusri, Payne, Brendan, Elliott, Ivo A M, Crowe, Stewart, Woodrow, Charles J, Karageorgopoulos, Drosos E, Davis, Peter J, Lord, Emily, Bannister, Oliver J, Dagens, Andrew B, Harrison, Thomas, Cole, Joby, Tunbridge, Anne, Choudry, Saher, Telfer, Adam, Jhibril, Ihsan, Atta, Syed N, Stone, Ben, Evans, Cariad, Ankcorn, Mike, Akili, Suha, Yavuz, Mehmet, Goodall, Vicky, Farrow, Sam, Mountford, Georgina, Cusack, Tomas-Paul, Beard, Kate, Sutton, Julian, Clark, Tristan, Mason, Annette, Vickers, Mike, Macallan, Derek, Bicanic, Tihana, Houston, Angela, Pope, Cassie, Tan, NgeeKeong, Ward, Christopher, Jones, Imogen, Banerjee, Rishi, Cohen, Jonathan, Emonts-le Clercq, Marieke, Porter, David, Riordan, Andrew, Sinha, Ruchi, Whittaker, Elizabeth, Beynon, William, Heskin, Jospeh, Milligan, Iain, Payne, Lara, AI Payne, Brendan, Elliott, Ivo AM, and Beard, Katie

Published
2023
Full Text
View/download PDF

6. KaryoCreate: A CRISPR-based technology to study chromosome-specific aneuploidy by targeting human centromeres

Author

Bosco, Nazario, Goldberg, Aleah, Zhao, Xin, Mays, Joseph C., Cheng, Pan, Johnson, Adam F., Bianchi, Joy J., Toscani, Cecilia, Di Tommaso, Elena, Katsnelson, Lizabeth, Annuar, Dania, Mei, Sally, Faitelson, Roni E., Pesselev, Ilan Y., Mohamed, Kareem S., Mermerian, Angela, Camacho-Hernandez, Elaine M., Gionco, Courtney A., Manikas, Julie, Tseng, Yi-Shuan, Sun, Zhengxi, Fani, Somayeh, Keegan, Sarah, Lippman, Scott M., Fenyö, David, Giunta, Simona, Santaguida, Stefano, and Davoli, Teresa

Published
2023
Full Text
View/download PDF

7. Mpox in people with advanced HIV infection: a global case series

Author

Leiro, Viviana, Marchetta, Lucila, Fernandez Pardal, Patricia, Figueroa, María Inés, Cahn, Pedro, Grabmeier-Pfistershammer, Katharina, Libois, Agnes, Liesenborghs, Laurens, Grinsztejn, Beatriz, Schechter, Mauro, dos Santos de Lemos, Alberto, Furtado Costa, Alvaro, Queiroz Rocha, Simone, Valdez Madruga, José, S. Tan, Darrell H., Mishra, Sharmistha, Shah, Shreya, Jorquera, Camila, Castillo, Alberto, Carrión, Mauricio, Cevallos, Nelson, Palich, Romain, Pourcher, Valerie, Rubenstein, Emma, Migaud, Pascal, Boesecke, Christoph, Hoffmann, Christian, Protopapas, Konstantinos, Nozza, Silvia, Cattelan, Anna Maria, Mussini, Cristina, d'Arminio Monforte, Antonella, Cruz Flores, Raúl Adrian, Pérez Barragán, Edgar, Rodríguez Guzmán, Alma Leticia, Ogoina, Dimie, Chika-Igwenyi, Nneka Marian, Chizaram, Onyeaghala, Valverde López, Jenny, García Tello, Angelica, Ubals, Maria, Vall, Martí, Mendoza, Adrià, Suñer, Clara, Clotet, Bonaventura, Bechini, Jordi, Lepe, Jose A, Navarro-Amuedo, M. Dolores, Bernadino, Jose Ignacio, Català, Alba, Tarín Vicente, Eloy José, González Rodríguez, Borja, Rodriguez-Mercader, Sergi, Sánchez-Martinez, Francisca, Cañas-Ruano, Esperanza, Parra-Navarro, Laura, Filén, Finn, Tallón de Lara, Carmen, Braun, Dominique, Piezzi, Vanja, Burkhard, Michael, Kovari, Helen, Mönch, Anja, Dunning, Jake, Simoes, Pedro, Nori, Achyuta, Keegan, Sarah, Thornhill, John P, Apea, Vanessa, Noori, Teymur, Jones, Joyce L., Judson, Seth, Gilliams, Elizabeth A., Hamill, Matthew M., Keruly, Jeanne, Henao Martínez, Andrés F., Lin, Aung, So, Jessica, Davar, Kusha, Villareal, Diana, Tapia Paredes, Miguel, Mitjà, Oriol, Alemany, Andrea, Marks, Michael, Lezama Mora, Jezer I, Rodríguez-Aldama, Juan Carlos, Torres Silva, Mayara Secco, Corral Herrera, Ever Arturo, Crabtree-Ramirez, Brenda, Blanco, José Luis, Girometti, Nicolo, Mazzotta, Valentina, Hazra, Aniruddha, Silva, Macarena, Montenegro-Idrogo, Juan José, Gebo, Kelly, Ghosn, Jade, Peña Vázquez, María Fernanda, Matos Prado, Eduardo, Unigwe, Uche, Villar-García, Judit, Wald-Dickler, Noah, Zucker, Jason, Paredes, Roger, Calmy, Alexandra, Waters, Laura, Galvan-Casas, Cristina, Walmsley, Sharon, and Orkin, Chloe M

Published
2023
Full Text
View/download PDF

8. Teacher and School Outcomes of the Physical Education and Physical Literacy (PEPL) Approach: A Pragmatic Cluster Randomised Controlled Trial of a Multicomponent Intervention to Improve Physical Literacy in Primary Schools

Author

Telford, Rohan M., Olive, Lisa S., Keegan, Richard J., Keegan, Sarah, and Telford, Richard D.

Abstract

Background: Physical education (PE) can be considered the centrepiece of school physical literacy (PL) programs, but ineffective lessons or an absence of PE across the public primary school system has raised concern. This study aimed to evaluate the implementation, acceptability and impact of teacher delivery of PE as part of a multicomponent Physical Education Physical Literacy (PEPL) approach, designed to improve classroom teachers' provision of PE and PL opportunities within a cluster of suburban primary schools. Method: Within a pragmatic randomised cluster-based trial with mixed methods, a PEPL coach was appointed to seven schools for one school year, with another seven schools continuing their usual practice as the control group. The coach's role was to support and professionally develop classroom teachers to teach PE and to create opportunities that develop PL inside and outside the school environment. Focusing on Grade 5 teachers, the implementation, acceptability and teacher impact were assessed using direct observations of PE teaching style, a daily log kept by the coach and interviews with principals and teachers. Results: The PEPL coach visited each school on average once a week for the 33 available weeks of the school year. There were several positive effects for teachers and schools. With no classroom teacher initially taking PE or classroom physical activity breaks, all seven teachers regularly introduced a PE lesson and activity breaks into their weekly schedule. PE class instructional time increased (intervention; +4.8 vs. control; -3.5 min/lesson; [beta] = 1.69; SE = 0.76; p = 0.05), with lessons of greater duration (intervention; +8.6 vs. control +1.9 min/lesson; [beta] = 1.14, SE = 0.58, p = 0.05) and moderate and vigorous physical activity increased 5.7 min in intervention classes (p < 0.05). The PEPL coach introduced regular physical activities before and after school and linked the schools with a national sports coaching scheme. Interviews indicated that the PEPL approach was both valued and well-accepted by staff, that classroom teacher confidence to teach PE increased and that principals perceived a shift toward a school 'culture' of physical activity. Conclusions: Well-received by classroom teachers and principals, the PEPL approach resulted in classroom teachers introducing both PE and activity breaks into their weekly teaching program and schools were linked to external sport coaching programs. These effects suggest that the PEPL approach enhanced opportunities for the development of physical literacy in this suburban primary school setting.

Published
2021
Full Text
View/download PDF

9. Student Outcomes of the Physical Education and Physical Literacy (PEPL) Approach: A Pragmatic Cluster Randomised Controlled Trial of a Multicomponent Intervention to Improve Physical Literacy in Primary Schools

Author

Telford, Rohan M., Olive, Lisa S., Keegan, Richard J., Keegan, Sarah, Barnett, Lisa M., and Telford, Richard D.

Abstract

Background: Health organisations such as the United Nations continue to place an expectation on school physical education (PE) programmes and wider school strategies to ensure students develop physical literacy and receive the well-established benefits of meeting physical activity guidelines. Barriers to meet this expectation such as lack of trained PE teachers, lack of time and greater emphasis on academic achievement are ongoing challenges to schools. The purpose of this study was to evaluate the impact of the multi-component Physical Education Physical Literacy (PEPL) intervention, designed to improve students' fundamental movement skill, perceived physical abilities and level of physical activity. Method: A qualified PE teacher implemented the PEPL intervention across seven schools, and another seven schools formed a control group as part of a randomised cluster-based trial. Grade 5 students (N = 318, age 10.4 years ± SD 0.4) completed assessments of physical activity, fundamental movement skill, attitudes towards PE, and self-perceptions of physical abilities before and after a 33-week intervention. Intervention effects were examined using general linear mixed models. Post-intervention focus groups with students were used to develop insights into experiences and outcomes. Results: With no significant gender interactions, the PEPL approach led to enhanced object control skills ([beta] = 1.62; SE = 0.61; p = 0.008), with little evidence of any other fundamental movement skill improvements in excess of those in the control group. There was also modest evidence for an effect on accelerometer measured moderate-to-vigorous physical activity (MVPA) during school time ([beta] = 4.50; SE = 2.39; p = 0.058), but this was not accompanied by any significant intervention effect over the entire week. Questionnaires indicated students in the PEPL programme became less satisfied with their own sporting ability ([beta] = -0.20; SE = 0.08; p = 0.013) but qualitative data analyses suggested that they enjoyed the PEPL approach experience, becoming more motivated and confident in their physical abilities. Conclusions: Evidence of enhanced object control skill, increased confidence and motivation to be physically active, and moderate evidence of more MVPA during school time, indicate that the introduction of the PEPL approach contributed to the development of student physical literacy. A decrease in perceived sporting competence warrants greater attention on student's self-perceptions in future iterations of the intervention.

Published
2021
Full Text
View/download PDF

12. CRL4.sup.AMBRA1 is a master regulator of D-type cyclins

Author

Simoneschi, Daniele, Rona, Gergely, Zhou, Nan, Jeong, Yeon-Tae, Jiang, Shaowen, Milletti, Giacomo, Arbini, Arnaldo A., O'Sullivan, Alfie, Wang, Andrew A., Nithikasem, Sorasicha, Keegan, Sarah, Siu, Yik, Cianfanelli, Valentina, Maiani, Emiliano, Nazio, Francesca, Cecconi, Francesco, and Boccalatte, Francesco

Subjects
Physiological aspects, Chemical properties, Genetic aspects, Research, Cytological research, Cell division -- Research, Ligases -- Genetic aspects -- Physiological aspects -- Chemical properties, Cyclins -- Physiological aspects -- Genetic aspects, Cell research
Abstract

Author(s): Daniele Simoneschi [sup.1] [sup.2] , Gergely Rona [sup.1] [sup.2] [sup.3] , Nan Zhou [sup.4] , Yeon-Tae Jeong [sup.1] [sup.2] , Shaowen Jiang [sup.1] [sup.2] , Giacomo Milletti [sup.5] [sup.6] [...], D-type cyclins are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer.sup.1, but the mechanisms that regulate their turnover are still being debated.sup.2,3. Here, by combining biochemical and genetics studies in somatic cells, we identify CRL4.sup.AMBRA1 (also known as CRL4.sup.DCAF3) as the ubiquitin ligase that targets all three D-type cyclins for degradation. During development, loss of Ambra1 induces the accumulation of D-type cyclins and retinoblastoma (RB) hyperphosphorylation and hyperproliferation, and results in defects of the nervous system that are reduced by treating pregnant mice with the FDA-approved CDK4 and CDK6 (CDK4/6) inhibitor abemaciclib. Moreover, AMBRA1 acts as a tumour suppressor in mouse models and low AMBRA1 mRNA levels are predictive of poor survival in cancer patients. Cancer hotspot mutations in D-type cyclins abrogate their binding to AMBRA1 and induce their stabilization. Finally, a whole-genome, CRISPR-Cas9 screen identified AMBRA1 as a regulator of the response to CDK4/6 inhibition. Loss of AMBRA1 reduces sensitivity to CDK4/6 inhibitors by promoting the formation of complexes of D-type cyclins with CDK2. Collectively, our results reveal the molecular mechanism that controls the stability of D-type cyclins during cell-cycle progression, in development and in human cancer, and implicate AMBRA1 as a critical regulator of the RB pathway. Biochemical and genetics studies identify CRL4.sup.AMBRA1 as the ubiquitin ligase that has a key role in regulating the stability of D-type cyclins during cell-cycle progression.

Published
2021
Full Text
View/download PDF

15. Physical Literacy and Teacher Professional Development

Author

Durden-Myers, Elizabeth J. and Keegan, Sarah

Abstract

Spanning different countries and research groups, physical literacy has been recognized as a valuable approach for aligning and optimizing physical education, physical activity and sports promotion. Physical literacy refers to an individual's capacity for sustaining a physically active lifestyle. Applying physical literacy as a concept to elementary physical education proposes a new, more inclusive, and potentially more effective approach to promoting lifelong engagement in physical activity. This article explores the role of professional development for generalist classroom teachers and specialist physical education teachers in nurturing physical literacy within physical education teaching practice, by identifying the desired characteristics of effective physical literacy professional development. The professionals at the forefront of delivering physical education, the teachers, need support in understanding the complexity of the concept of physical literacy and how it can be nurtured within their practice. Providing effective and responsive professional development for teachers is essential if children are to become more physically active over their lifetime.

Published
2019
Full Text
View/download PDF

16. Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

Author

Hashimi, Abdul Samad, Pico, Alexander R., Karpova, Alla, Charamut, Alyssa, Paulovich, Amanda G., Perou, Amy M., Malovannaya, Anna, Marrero-Oliveras, Annette, Agarwal, Anupriya, Hindenach, Barbara, Pruetz, Barbara, Kim, Beom-Jun, Druker, Brian J., Newton, Chelsea J., Birger, Chet, Jones, Corbin D., Tognon, Cristina, Mani, D.R., Valley, Dana R., Rohrer, Daniel C., Zhou, Daniel C., Tansil, Darlene, Chesla, David, Heiman, David, Wheeler, David, Tan, Donghui, Chan, Doug, Demir, Emek, Malc, Ewa, Modugno, Francesmary, Getz, Gaddy, Hostetter, Galen, Wilson, George D., Hart, Gerald W., Zhu, Heng, Liu, Hongwei, Culpepper, Houston, Sun, Hua, Zhou, Hua, Day, Jacob, Suh, James, Huang, Jasmine, McDermott, Jason, Whiteaker, Jeffrey R., Tyner, Jeffrey W., Eschbacher, Jennifer, Chen, Jin, McGee, John, Zhu, Jun, Ketchum, Karen A., Rodland, Karin D., Clauser, Karl, Robinson, Karna, Krug, Karsten, Hoadley, Katherine A., Um, Ki Sung, Elburn, Kim, Holloway, Kimberly, Wang, Liang-Bo, Blumenberg, Lili, Hannick, Linda, Qi, Liqun, Sokoll, Lori J., Cornwell, MacIntosh, Loriaux, Marc, Domagalski, Marcin J., Gritsenko, Marina A., Anderson, Matthew, Monroe, Matthew E., Ellis, Matthew J., Dyer, Maureen, Anurag, Meenakshi, Burke, Meghan C., Borucki, Melissa, Gillette, Michael A., Birrer, Michael J., Lewis, Michael, Ittmann, Michael M., Smith, Michael, Vernon, Michael, Chaikin, Michelle, Chheda, Milan G., Khan, Munziba, Roche, Nancy, Edwards, Nathan J., Vatanian, Negin, Tignor, Nicole, Beckmann, Noam, Grady, Pamela, Castro, Patricia, Piehowski, Paul, McGarvey, Peter B., Mieczkowski, Piotr, Hariharan, Pushpa, Gao, Qingsong, Dhir, Rajiv, Kothadia, Ramani Bhupendra, Thangudu, Ratna R., Montgomery, Rebecca, Jayasinghe, Reyka G., Smith, Richard D., Edwards, Robert, Zelt, Robert, Bremner, Ross, Liu, Ruiyang, Hong, Runyu, Mareedu, Sailaja, Payne, Samuel H., Cottingham, Sandra, Markey, Sanford P., Jewell, Scott D., Patel, Shalin, Satpathy, Shankha, Richey, Shannon, Davies, Sherri R., Cai, Shuang, Boca, Simina M., Patil, Snehal, Sengupta, Sohini, Carter, Sonya, Gabriel, Stacey, Thomas, Stefani N., De Young, Stephanie, Stein, Stephen E., Carr, Steven A., Foltz, Steven M., Hilsenbeck, Sue, Krubit, Tanya, Liu, Tao, Skelly, Tara, Westbrook, Thomas, Borate, Uma, Velvulou, Uma, Petyuk, Vladislav A., Bocik, William E., Chen, Xi, Shi, Yan, Geffen, Yifat, Lu, Yihao, Wang, Ying, Maruvka, Yosef, Li, Zhi, Shi, Zhiao, Tu, Zhidong, Clark, David J., Dhanasekaran, Saravana M., Petralia, Francesca, Pan, Jianbo, Song, Xiaoyu, Hu, Yingwei, da Veiga Leprevost, Felipe, Reva, Boris, Lih, Tung-Shing M., Chang, Hui-Yin, Ma, Weiping, Huang, Chen, Ricketts, Christopher J., Chen, Lijun, Krek, Azra, Li, Yize, Rykunov, Dmitry, Li, Qing Kay, Chen, Lin S., Ozbek, Umut, Vasaikar, Suhas, Wu, Yige, Yoo, Seungyeul, Chowdhury, Shrabanti, Wyczalkowski, Matthew A., Ji, Jiayi, Schnaubelt, Michael, Kong, Andy, Sethuraman, Sunantha, Avtonomov, Dmitry M., Ao, Minghui, Colaprico, Antonio, Cao, Song, Cho, Kyung-Cho, Kalayci, Selim, Ma, Shiyong, Liu, Wenke, Ruggles, Kelly, Calinawan, Anna, Gümüş, Zeynep H., Geiszler, Daniel, Kawaler, Emily, Teo, Guo Ci, Wen, Bo, Zhang, Yuping, Keegan, Sarah, Li, Kai, Chen, Feng, Edwards, Nathan, Pierorazio, Phillip M., Chen, Xi Steven, Pavlovich, Christian P., Hakimi, A. Ari, Brominski, Gabriel, Hsieh, James J., Antczak, Andrzej, Omelchenko, Tatiana, Lubinski, Jan, Wiznerowicz, Maciej, Linehan, W. Marston, Kinsinger, Christopher R., Thiagarajan, Mathangi, Boja, Emily S., Mesri, Mehdi, Hiltke, Tara, Robles, Ana I., Rodriguez, Henry, Qian, Jiang, Fenyö, David, Zhang, Bing, Ding, Li, Schadt, Eric, Chinnaiyan, Arul M., Zhang, Zhen, Omenn, Gilbert S., Cieslik, Marcin, Chan, Daniel W., Nesvizhskii, Alexey I., Wang, Pei, and Zhang, Hui

Published
2019
Full Text
View/download PDF

17. D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability

Author

Rona, Gergely, primary, Miwatani-Minter, Bearach, additional, Zhang, Qingyue, additional, Goldberg, Hailey V., additional, Kerzhnerman, Marc A., additional, Howard, Jesse B., additional, Simoneschi, Daniele, additional, Lane, Ethan, additional, Hobbs, John W., additional, Sassani, Elizabeth, additional, Wang, Andrew A., additional, Keegan, Sarah, additional, Laverty, Daniel J., additional, Piett, Cortt G., additional, Pongor, Lorinc S., additional, Xu, Miranda Li, additional, Andrade, Joshua, additional, Thomas, Anish, additional, Sicinski, Piotr, additional, Askenazi, Manor, additional, Ueberheide, Beatrix, additional, Fenyö, David, additional, Nagel, Zachary D., additional, and Pagano, Michele, additional

Published
2024
Full Text
View/download PDF

19. Engineered transcription-associated Cas9 targeting in eukaryotic cells

Author

Goldberg, Gregory W., primary, Kogenaru, Manjunatha, additional, Keegan, Sarah, additional, Haase, Max A. B., additional, Kagermazova, Larisa, additional, Arias, Mauricio A., additional, Onyebeke, Kenenna, additional, Adams, Samantha, additional, Fenyo, David, additional, Noyes, Marcus B., additional, and Boeke, Jef D, additional

Published
2023
Full Text
View/download PDF

23. Mpox in people with advanced HIV infection: a global case series

Author

Mitjà, Oriol, primary, Alemany, Andrea, additional, Marks, Michael, additional, Lezama Mora, Jezer I, additional, Rodríguez-Aldama, Juan Carlos, additional, Torres Silva, Mayara Secco, additional, Corral Herrera, Ever Arturo, additional, Crabtree-Ramirez, Brenda, additional, Blanco, José Luis, additional, Girometti, Nicolo, additional, Mazzotta, Valentina, additional, Hazra, Aniruddha, additional, Silva, Macarena, additional, Montenegro-Idrogo, Juan José, additional, Gebo, Kelly, additional, Ghosn, Jade, additional, Peña Vázquez, María Fernanda, additional, Matos Prado, Eduardo, additional, Unigwe, Uche, additional, Villar-García, Judit, additional, Wald-Dickler, Noah, additional, Zucker, Jason, additional, Paredes, Roger, additional, Calmy, Alexandra, additional, Waters, Laura, additional, Galvan-Casas, Cristina, additional, Walmsley, Sharon, additional, Orkin, Chloe M, additional, Leiro, Viviana, additional, Marchetta, Lucila, additional, Fernandez Pardal, Patricia, additional, Figueroa, María Inés, additional, Cahn, Pedro, additional, Grabmeier-Pfistershammer, Katharina, additional, Libois, Agnes, additional, Liesenborghs, Laurens, additional, Grinsztejn, Beatriz, additional, Schechter, Mauro, additional, dos Santos de Lemos, Alberto, additional, Furtado Costa, Alvaro, additional, Queiroz Rocha, Simone, additional, Valdez Madruga, José, additional, S. Tan, Darrell H., additional, Mishra, Sharmistha, additional, Shah, Shreya, additional, Jorquera, Camila, additional, Castillo, Alberto, additional, Carrión, Mauricio, additional, Cevallos, Nelson, additional, Palich, Romain, additional, Pourcher, Valerie, additional, Rubenstein, Emma, additional, Migaud, Pascal, additional, Boesecke, Christoph, additional, Hoffmann, Christian, additional, Protopapas, Konstantinos, additional, Nozza, Silvia, additional, Cattelan, Anna Maria, additional, Mussini, Cristina, additional, d'Arminio Monforte, Antonella, additional, Cruz Flores, Raúl Adrian, additional, Pérez Barragán, Edgar, additional, Rodríguez Guzmán, Alma Leticia, additional, Ogoina, Dimie, additional, Chika-Igwenyi, Nneka Marian, additional, Chizaram, Onyeaghala, additional, Valverde López, Jenny, additional, García Tello, Angelica, additional, Ubals, Maria, additional, Vall, Martí, additional, Mendoza, Adrià, additional, Suñer, Clara, additional, Clotet, Bonaventura, additional, Bechini, Jordi, additional, Lepe, Jose A, additional, Navarro-Amuedo, M. Dolores, additional, Bernadino, Jose Ignacio, additional, Català, Alba, additional, Tarín Vicente, Eloy José, additional, González Rodríguez, Borja, additional, Rodriguez-Mercader, Sergi, additional, Sánchez-Martinez, Francisca, additional, Cañas-Ruano, Esperanza, additional, Parra-Navarro, Laura, additional, Filén, Finn, additional, Tallón de Lara, Carmen, additional, Braun, Dominique, additional, Piezzi, Vanja, additional, Burkhard, Michael, additional, Kovari, Helen, additional, Mönch, Anja, additional, Dunning, Jake, additional, Simoes, Pedro, additional, Nori, Achyuta, additional, Keegan, Sarah, additional, Thornhill, John P, additional, Apea, Vanessa, additional, Noori, Teymur, additional, Jones, Joyce L., additional, Judson, Seth, additional, Gilliams, Elizabeth A., additional, Hammill, Matthew, additional, Keruly, Jeanne, additional, Henao Martínez, Andrés F., additional, Lin, Aung, additional, So, Jessica, additional, Davar, Kusha, additional, and Villareal, Diana, additional

Published
2023
Full Text
View/download PDF

26. Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study

Author

Fink, Douglas L, primary, Callaby, Helen, additional, Luintel, Akish, additional, Beynon, William, additional, Bond, Helena, additional, Lim, Eleanor Y, additional, Gkrania-Klotsas, Effrossyni, additional, Heskin, Jospeh, additional, Bracchi, Margherita, additional, Rathish, Balram, additional, Milligan, Iain, additional, O'Hara, Geraldine, additional, Rimmer, Stephanie, additional, Peters, Joanna R, additional, Payne, Lara, additional, Mody, Nisha, additional, Hodgson, Bethany, additional, Lewthwaite, Penny, additional, Lester, Rebecca, additional, Woolley, Stephen D, additional, Sturdy, Ann, additional, Whittington, Ashley, additional, Johnson, Leann, additional, Jacobs, Nathan, additional, Quartey, John, additional, AI Payne, Brendan, additional, Crowe, Stewart, additional, Elliott, Ivo AM, additional, Harrison, Thomas, additional, Cole, Joby, additional, Beard, Katie, additional, Cusack, Tomas-Paul, additional, Jones, Imogen, additional, Banerjee, Rishi, additional, Rampling, Tommy, additional, Dunning, Jake, additional, Fink, Douglas, additional, Rodger, Alison, additional, Bhagani, Sanjay, additional, Lamb, Lucy, additional, Moores, Rachel, additional, Lee, Simon, additional, Brown, Colin, additional, Hopkins, Susan, additional, Mepham, Stephen, additional, Warren, Simon, additional, Molloy, Aoife, additional, Cropley, Ian, additional, Kew, Alex, additional, Karunaharan, Natasha, additional, Scobie, Antonia, additional, Hart, Jennifer, additional, Irish, Dianne, additional, Haque, Tanzina, additional, Jalal, Hamid, additional, Smith, Robin, additional, Mack, Damien, additional, Barber, Tristan, additional, Burns, Fiona, additional, Miller, Robert, additional, Hamlyn, Eleanor, additional, Simoes, Pedro, additional, Athan, Breda, additional, Abrahamsen, Jennifer, additional, Joyce, Jessica, additional, Taylor, Caroline, additional, Reddecliffe, Sally, additional, Miller, Chloe, additional, Reeve, Brooke, additional, Kingston, Hugh, additional, Crocker-Buque, Tim, additional, Massie, Nicolas, additional, Dhariwal, Ankush, additional, Jayakumar, Angelina, additional, Hammond, Robert, additional, Bramley, Alexandra, additional, Kanitkar, Tanmay, additional, Maynard-Smith, Laura, additional, Gil, Eliza, additional, O'Connor, Cavan, additional, Cocker, Derek, additional, Spicer, Wendy, additional, Lanzman, Marisa, additional, Thacker, Meera, additional, Anorson, Zoe, additional, Patel, Dharmesh, additional, Williams, Alan, additional, Houlihan, Catherine, additional, Wakerley, Dominic, additional, Gordon, Claire, additional, Bailey, Daniel, additional, Furneaux, Jenna, additional, Bown, Abbie, additional, Truelove, Elizabeth, additional, Killip, Marian, additional, Jackson, David, additional, Beetar-King, Tracy, additional, Arnold, Ulrike, additional, Strachan, Rhea, additional, Matthew, Jones, additional, Matthew, Hannah, additional, Osborne, Jane, additional, Vipond, Richard, additional, Gibney, Barry, additional, Owen, Jodie, additional, Beynon, Will, additional, Hunter, Michael, additional, McCorry, Louise, additional, Emerson, Carol, additional, Quah, Say, additional, Todd, Suzanne, additional, McCarty, Emma, additional, Walker, Eoin, additional, Feeney, Susan, additional, Curran, Tanya, additional, Li, Kathy, additional, Mullan, JD, additional, Jackson, Kate, additional, Nelson, Peter, additional, Lewis, Kevin, additional, McNicol, Mark, additional, Pratt, Marcus, additional, Smith, Anna, additional, Vos, Erin, additional, Alsalemee, Fahad, additional, O Leary, Daniel, additional, Canny, John, additional, McGinnity, Katherine, additional, Culbert, Carly, additional, McDowell, Conor, additional, McQuillan, Cathy, additional, Jeong, Eunjin, additional, Glass, Lynsey, additional, Dyche, Jessica, additional, McClean, Paula, additional, Stewart, Rebecca, additional, Ursolino, Harold, additional, Perry, Melissa, additional, McCormick, Hannah, additional, Lim, Eleanor, additional, Heskin, Joseph, additional, Brown, Nicklas, additional, Juniper, Thomas, additional, Mora-Peris, Borja, additional, Dalla-Pria, Alessia, additional, Mackie, Nicola, additional, Garvey, Lucy, additional, Winston, Alan, additional, Cooke, Graham, additional, Nelson, Mark, additional, Kilbride, Emer, additional, Elbishi, Ala, additional, Kerrigan, William, additional, Silva, Joshua, additional, Gohil, Jesal, additional, Payagala, Sasha, additional, Walters, Yasmin, additional, Smith, Joanna, additional, Goodfellow, Jonathan, additional, Lyons, Kitty, additional, Tung, Hsiu, additional, Patel, Kinjal, additional, Henderson, Merle, additional, Butler, Michael, additional, Peres, Edu, additional, Silva Carvalho, Taiana, additional, Joly, Antoine, additional, Dickinson, Molly, additional, Moore, Luke, additional, Mughal, Nabeela, additional, Hughes, Stephen, additional, Chitlangia, Shrada, additional, Viramgana, Priyanka, additional, Byrne, Ruth, additional, Randell, Paul, additional, Strangis, Luigi, additional, Poveda, Nicola, additional, Bovey, Deborah, additional, Richardson, Poppy, additional, Heaslip, Vivian, additional, Higgs, Christopher, additional, Boffito, Marta, additional, Girometti, Nicolo, additional, Whitlock, Gary, additional, Tittle, Victoria, additional, Jones, Rachel, additional, Rayment, Michael, additional, Scott, Christopher, additional, Asboe, David, additional, Pond, Marcus, additional, Muir, David, additional, Abeywickrema, Movin, additional, Bailey, Sarah-Lou, additional, Boyd, Sara, additional, Da Silva Fontoura, Dayana, additional, Daunt, Anna, additional, Mason, Claire, additional, Murphy, Jamie, additional, Naidu, Vasanth, additional, Patel, Aatish, additional, Pley, Caitlin, additional, Redmore, Ethan, additional, Sharrocks, Katherine, additional, Snell, Luke, additional, Sundramoorthi, Rohan, additional, Tam, Jerry, additional, Brown, Aisling, additional, Douthwaite, Sam, additional, Goodman, Anna, additional, Nebbia, Gaia, additional, Newsholme, William, additional, Price, Nicholas, additional, Shaw, Emily, additional, Salam, Alex, additional, van Nispen tot Pannerden, Claire, additional, Winslow, Helen, additional, Bilinska, Julia, additional, Keegan, Sarah, additional, Coleman, Harry, additional, Doctor, Jessica, additional, Moini, Nasreen, additional, Chilton, Daniella, additional, Haidari, Golaleh, additional, Simons, Rebecca, additional, Kulasegaram, Rajababu, additional, Larbalestier, Nick, additional, Nori, Achyuta, additional, Potter, Jack, additional, Tuudah, Cecilia, additional, Wade, Paul, additional, Travers, Alexandra, additional, Dunford, Sarah, additional, Greenwood, Joshua, additional, Oledimmah, Georgina, additional, Gyampo, Lesley, additional, SA Pinto, Pedro, additional, Muse, AbdulKadir, additional, Parker, Zoe, additional, Alexander, Charlotte, additional, Khan, Alexander, additional, Ajayi, Medinat, additional, Baltazar, Abigail, additional, Sharella, Davis, additional, Hersi, Nasra, additional, Nguyen, Thuy, additional, Timbo, Rugiatu, additional, Jalloh, Ismail, additional, Bryan, Susan, additional, Clarke, Patricia, additional, Kerr, Marcia, additional, Amedu, Fidelis, additional, BohoBonaba, Maria, additional, Haque, Sarah, additional, Howson, Michelle, additional, Tambilawan, Norbai, additional, Yupanqui Estay, Soledad, additional, Bangura, Hawanatu, additional, Gideon, Tseday, additional, Jerome-oboh, Damilola, additional, Tetteh, Linda, additional, Nwagu, Chioma, additional, Agbaglah, Viwoalo, additional, Narag, Nona, additional, Zaveri, Mahima, additional, Ni Luanaigh, Maedhbh, additional, Keane, Peggy, additional, Peters, Joanna, additional, Abbara, Aula, additional, Dosekun, Olamide, additional, Bolland, Mhairi, additional, Stafford, Adam, additional, Saleh, Dina, additional, Sheridan, Rhianna, additional, Davies, Ella, additional, Sun, Kristi, additional, Gilchrist, Mark, additional, Kukadia, Priti, additional, Embrahimsa, Muhammed, additional, Chiu, Christopher, additional, Taylor, Lauren, additional, Short, Charlotte, additional, Alagratnam, Jasmini, additional, Jayaweera, Iresh, additional, Gundugola, Kavitha, additional, Quinn, Killian, additional, Nic Fhogartaigh, Caoimhe, additional, Kaur, Nivenjit, additional, Bholah, Salmaan, additional, Kantha, Kajann, additional, Youngs, Jonathan, additional, Lampejo, Temi, additional, Pitto, Nicholas, additional, Lawrence, David, additional, Middleditch, Holly, additional, Dominguez-Dominguez, Lourdes, additional, Ratnappuli, Ayoma, additional, Al-Hashimi, Sara, additional, Oliveira, Amelia, additional, Ottaway, Zoe, additional, Mulka, Larissa, additional, Neary, Anne, additional, Downey, Michael, additional, Lucy, Danielle, additional, McCallum, Craig, additional, Beadsworth, Michael, additional, Ratcliffe, Libuse, additional, Fletcher, Tom, additional, Davies, Gerry, additional, Wong, Nicholas, additional, Aston, Stephen, additional, Wingfield, Thomas, additional, Blanchard, Thomas, additional, Hine, Paul, additional, Woolley, Stephen, additional, Gould, Susie, additional, Smith, Christopher, additional, Abouyannis, Michael, additional, Atomode, Abolaji, additional, Cruise, James, additional, Samual, Merna, additional, Scott, Nicola, additional, Srirathan, Vino, additional, Lewis, Joseph, additional, Richards, Lauren, additional, Cummings, Mary-Ann, additional, Gillan, Emily, additional, Peers, Rebecca, additional, Tickle, Amy, additional, Keating, Grace, additional, Chinyanda, Tendi, additional, Sanchez, Mav, additional, Harrison, Daniel, additional, Hoyle, Marie-Claire, additional, Metcalfe, Ben, additional, Taylor, Jennifer, additional, Johnson, Nicky, additional, Kelle, Neil, additional, McDowell, Kirsty, additional, Richardson, Ian, additional, Saguidan, Monette, additional, Farmer, Nicky, additional, Gillespie, Angella, additional, Willoughby, Shay, additional, Parker, Samantha, additional, Avulan, Shamseena, additional, Arif, Shazia, additional, Marshall, Suzanne, additional, Carlisle, David, additional, Rezaei, Mohsen, additional, Booth, Angela, additional, Watts, Joanne, additional, Tremarco, Lauren, additional, Jeyanayagam, Priyanga, additional, Ubochi, Odinaka, additional, Vagianos, Daniel, additional, Richardson, Mark, additional, Jarvis, Anthony, additional, Gow, Kyra, additional, Walmsley, Jade, additional, O'keefe, Adam, additional, Smielewska, Anna, additional, Hopkins, Mark, additional, Balane, Fatima, additional, Bradley, Sarah, additional, Corrah, Tumena, additional, Daquiz, Venus, additional, Dugan, Christopher, additional, Elliot, Joshua, additional, Foley, Fiona, additional, Friday, Dawn, additional, Gamit, May, additional, Garner, David, additional, Gokani, Karishma, additional, John, Laurence, additional, Joseph, Deepa, additional, Khan, Nuzhath, additional, Mamuyac, Cherifer, additional, McGregor, Alastair, additional, McSorley, John, additional, Papineni, Padmasayee, additional, Parris, Victoria, additional, Rubinstein, Luciana, additional, Rycroft, Julian, additional, Salinas, Kelcy, additional, Salinas, Jason, additional, Sebatian, Jency, additional, Smith, Melanie, additional, Tejero Garcia, Marina, additional, Ume, Uchenna, additional, Vicentine, Margarete, additional, Wallis, Gabriel, additional, Bonington, Alec, additional, Uriel, Alison, additional, Ustianowski, Andrew, additional, Dancso, Balazs, additional, Hogan, Celia, additional, van Halsema, Clare, additional, Vilar, F Javier, additional, Devine, Karen, additional, Ajdukiewicz, Katherine, additional, Rajendran, Rajesh, additional, Ghosh, Samit, additional, Riste, Michael, additional, Machin, Nicholas, additional, Babu, Chitra, additional, Ahmad, Shazaad, additional, Obeng, Dorcas, additional, Dave, Farnaz, additional, Conolley, Gavin, additional, Thompson, Joseph, additional, Tickell-Painter, Maya, additional, Chakravorty, Prasun, additional, Pringle, Rachel, additional, Zafar, Mohammad, additional, Lawrence, Sarah, additional, Sanchez-Gonzalez, Amada, additional, Fernandez, Cristina, additional, Dawson, Lynsey, additional, Carey, David, additional, Howarth-Maddison, Molly, additional, Moody, Samuel, additional, Upton, Rebecca, additional, Apthorp, Christina, additional, Murray, Charlotte, additional, Salthouse, Kirstie, additional, Nadeem, Sabah, additional, Ridley, Grant, additional, White, Francesca, additional, Brown, Andrew, additional, Lawless, Michael, additional, Mohamed, Mohamed, additional, Mulligan, Robert, additional, Belfield, Amy, additional, Brolly, Jacob, additional, Calderon, Maria, additional, Cheveau, James, additional, Cullinan, Milo, additional, Garrad, Sophie, additional, Griffiths, Will, additional, Ireland, Aidan, additional, Ireland, Peter, additional, Milne, Charlotte, additional, Nwajiugo, Paul, additional, Ghavami-Kia, Bijan, additional, Duncan, Chris, additional, Evans, Adam, additional, Hunter, Ewan, additional, Price, Ashley, additional, Schmid, Matthias, additional, Schwab, Uli, additional, Taha, Yusri, additional, Payne, Brendan, additional, Elliott, Ivo, additional, Woodrow, Charles, additional, Karageorgopoulos, Drosos, additional, Davis, Peter, additional, Lord, Emily, additional, Bannister, Oliver, additional, Dagens, Andrew, additional, Tunbridge, Anne, additional, Choudry, Saher, additional, Telfer, Adam, additional, Jhibril, Ihsan, additional, Atta, Syed, additional, Stone, Ben, additional, Evans, Cariad, additional, Ankcorn, Mike, additional, Akili, Suha, additional, Yavuz, Mehmet, additional, Goodall, Vicky, additional, Farrow, Sam, additional, Mountford, Georgina, additional, Beard, Kate, additional, Sutton, Julian, additional, Clark, Tristan, additional, Mason, Annette, additional, Vickers, Mike, additional, Macallan, Derek, additional, Bicanic, Tihana, additional, Houston, Angela, additional, Pope, Cassie, additional, Tan, NgeeKeong, additional, Ward, Christopher, additional, Cohen, Jonathan, additional, Emonts-le Clercq, Marieke, additional, Porter, David, additional, Riordan, Andrew, additional, Sinha, Ruchi, additional, and Whittaker, Elizabeth, additional

Published
2022
Full Text
View/download PDF

28. KaryoCreate: a new CRISPR-based technology to generate chromosome-specific aneuploidy by targeting human centromeres

Author

Bosco, Nazario, primary, Goldberg, Aleah, additional, Johnson, Adam F, additional, Zhao, Xin, additional, Mays, Joseph C, additional, Cheng, Pan, additional, Bianchi, Joy J, additional, Toscani, Cecilia, additional, Katsnelson, Lizabeth, additional, Annuar, Dania, additional, Mei, Sally, additional, Faitelson, Roni E, additional, Pesselev, Ilan Y, additional, Mohamed, Kareem S, additional, Mermerian, Angela, additional, Camacho-Hernandez, Elaine M, additional, Gionco, Courtney A, additional, Manikas, Julie, additional, Tseng, Yi-Shuan, additional, Sun, Zhengxi, additional, Fani, Somayeh, additional, Keegan, Sarah, additional, Lippman, Scott M, additional, Fenyö, David, additional, Santaguida, Stefano, additional, and Davoli, Teresa, additional

Published
2022
Full Text
View/download PDF

29. VRTEACHER PROJECT: A REVOLUTIONARY APPROACH TO TEACHER EDUCATION USING VIRTUAL REALITY.

Author

Stavroulia, Kalliopi Evangelia, Pyrini, Anastasia, Álvarez Testillano, Isabel, Keegan, Sarah, Debattista, Martin, Ayo, Telmo Zarraonandia, Roussias, Christos, Sanz Prieto, Mariano, Díaz Pérez, Paloma, and Lanitis, Andreas

Subjects
TEACHER education, VIRTUAL reality, PROJECT management, EMPATHY, EDUCATIONAL planning
Abstract

This paper presents the rationale behind the VRTEACHER project and the integration of Virtual Reality (VR) technology in teacher education. The paper explores how VR and perspective-taking can promote the development of teacher's competences such as empathy. Furthermore, the paper provides an overview of the project's methodology, the VR application developed, and some preliminary results related to the impact of VR-based training, emphasizing the potential benefits in terms of enhancing teaching practices, promoting inclusivity, and fostering a deeper understanding of students' experiences. The paper aims to contribute to the existing body of knowledge on the integration of VR technology in teacher education. [ABSTRACT FROM AUTHOR]

Published
2023

31. Condensation of LINE-1 is critical for retrotransposition.

Author

Si, Srinjoy, Keegan, Sarah, Ettefa, Farida, Denes, Lance T., Boeke, Jef D., and Holt, Liam J.

Subjects
*CONDENSATION, *RNA-binding proteins, *REVERSE transcriptase, *ENDONUCLEASES, *HUMAN genome, *ELECTROSTATIC interaction, *NUCLEOPROTEINS
Abstract

LINE-1 (L1) is the only autonomously active retrotransposon in the human genome, and accounts for 17% of the human genome. The L1 mRNA encodes two proteins, ORF1p and ORF2p, both essential for retrotransposition. ORF2p has reverse transcriptase and endonuclease activities, while ORF1p is a homotrimeric RNA-binding protein with poorly understood function. Here, we show that condensation of ORF1p is critical for L1 retrotransposition. Using a combination of biochemical reconstitution and live-cell imaging, we demonstrate that electrostatic interactions and trimer conformational dynamics together tune the properties of ORF1p assemblies to allow for efficient L1 ribonucleoprotein (RNP) complex formation in cells. Furthermore, we relate the dynamics of ORF1p assembly and RNP condensate material properties to the ability to complete the entire retrotransposon life-cycle. Mutations that prevented ORF1p condensation led to loss of retrotransposition activity, while orthogonal restoration of coiled-coil conformational flexibility rescued both condensation and retrotransposition. Based on these observations, we propose that dynamic ORF1p oligomerization on L1 RNA drives the formation of an L1 RNP condensate that is essential for retrotransposition. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

32. Genetically encoded multimeric (GEM) nanoparticles probe the biophysical properties of the nucleus

Author

Szoradi, Tamas, primary, Shu, Tong, additional, Xie, Ying, additional, Kidiyoor, Gururaj R., additional, Herzog, Nora L., additional, Saxena, Shivanjali, additional, Bonucci, Martina, additional, Brittingham, Gregory, additional, Lemiere, Joel, additional, Keegan, Sarah, additional, Bazley, Andrew, additional, Fenyo, David, additional, Chang, Fred, additional, Delarue, Morgan, additional, and Holt, Liam J., additional

Published
2022
Full Text
View/download PDF

33. Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

Author

Mast, Fred D, primary, Fridy, Peter C, primary, Ketaren, Natalia E, primary, Wang, Junjie, primary, Jacobs, Erica Y, primary, Olivier, Jean Paul, primary, Sanyal, Tanmoy, additional, Molloy, Kelly R, additional, Schmidt, Fabian, additional, Rutkowska, Magdalena, additional, Weisblum, Yiska, additional, Rich, Lucille M, additional, Vanderwall, Elizabeth R, additional, Dambrauskas, Nicholas, additional, Vigdorovich, Vladimir, additional, Keegan, Sarah, additional, Jiler, Jacob B, additional, Stein, Milana E, additional, Olinares, Paul Dominic B, additional, Herlands, Louis, additional, Hatziioannou, Theodora, additional, Sather, D Noah, additional, Debley, Jason S, additional, Fenyö, David, additional, Sali, Andrej, additional, Bieniasz, Paul D, additional, Aitchison, John D, additional, Chait, Brian T, additional, and Rout, Michael P, additional

Published
2021
Full Text
View/download PDF

35. nucGEMs probe the biophysical properties of the nucleoplasm

Author

Shu, Tong, primary, Szórádi, Tamás, additional, Kidiyoor, Gururaj R., additional, Xie, Ying, additional, Herzog, Nora L., additional, Bazley, Andrew, additional, Bonucci, Martina, additional, Keegan, Sarah, additional, Saxena, Shivanjali, additional, Ettefa, Farida, additional, Brittingham, Gregory, additional, Lemiere, Joël, additional, Fenyö, David, additional, Chang, Fred, additional, Delarue, Morgan, additional, and Holt, Liam J., additional

Published
2021
Full Text
View/download PDF

36. Author response: Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

Author

Mast, Fred D, primary, Fridy, Peter C, primary, Ketaren, Natalia E, primary, Wang, Junjie, primary, Jacobs, Erica Y, primary, Olivier, Jean Paul, primary, Sanyal, Tanmoy, additional, Molloy, Kelly R, additional, Schmidt, Fabian, additional, Rutkowska, Magdalena, additional, Weisblum, Yiska, additional, Rich, Lucille M, additional, Vanderwall, Elizabeth R, additional, Dambrauskas, Nicholas, additional, Vigdorovich, Vladimir, additional, Keegan, Sarah, additional, Jiler, Jacob B, additional, Stein, Milana E, additional, Olinares, Paul Dominic B, additional, Herlands, Louis, additional, Hatziioannou, Theodora, additional, Sather, D Noah, additional, Debley, Jason S, additional, Fenyö, David, additional, Sali, Andrej, additional, Bieniasz, Paul D, additional, Aitchison, John D, additional, Chait, Brian T, additional, and Rout, Michael P, additional

Published
2021
Full Text
View/download PDF

39. Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2

Author

Mast, Fred D., primary, Fridy, Peter C., additional, Ketaren, Natalia E., additional, Wang, Junjie, additional, Jacobs, Erica Y., additional, Olivier, Jean Paul, additional, Sanyal, Tanmoy, additional, Molloy, Kelly R., additional, Schmidt, Fabian, additional, Rutkowska, Magda, additional, Weisblum, Yiska, additional, Rich, Lucille M., additional, Vanderwall, Elizabeth R., additional, Dambrauskas, Nicolas, additional, Vigdorovich, Vladimir, additional, Keegan, Sarah, additional, Jiler, Jacob B., additional, Stein, Milana E., additional, Olinares, Paul Dominic B., additional, Hatziioannou, Theodora, additional, Sather, D. Noah, additional, Debley, Jason S., additional, Fenyö, David, additional, Sali, Andrej, additional, Bieniasz, Paul D., additional, Aitchison, John D., additional, Chait, Brian T., additional, and Rout, Michael P., additional

Published
2021
Full Text
View/download PDF

41. Structural and Functional Characterization of a Na v 1.5-Mitochondrial Couplon

Author

Pérez-Hernández, Marta, primary, Leo-Macias, Alejandra, additional, Keegan, Sarah, additional, Jouni, Mariam, additional, Kim, Joon-Chul, additional, Agullo-Pascual, Esperanza, additional, Vermij, Sarah, additional, Zhang, Mingliang, additional, Liang, Feng-Xia, additional, Burridge, Paul, additional, Fenyo, David, additional, Rothenberg, Eli, additional, and Delmar, Mario, additional

Published
2021
Full Text
View/download PDF

46. Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

Author

Clark, David J., primary, Dhanasekaran, Saravana M., additional, Petralia, Francesca, additional, Pan, Jianbo, additional, Song, Xiaoyu, additional, Hu, Yingwei, additional, da Veiga Leprevost, Felipe, additional, Reva, Boris, additional, Lih, Tung-Shing M., additional, Chang, Hui-Yin, additional, Ma, Weiping, additional, Huang, Chen, additional, Ricketts, Christopher J., additional, Chen, Lijun, additional, Krek, Azra, additional, Li, Yize, additional, Rykunov, Dmitry, additional, Li, Qing Kay, additional, Chen, Lin S., additional, Ozbek, Umut, additional, Vasaikar, Suhas, additional, Wu, Yige, additional, Yoo, Seungyeul, additional, Chowdhury, Shrabanti, additional, Wyczalkowski, Matthew A., additional, Ji, Jiayi, additional, Schnaubelt, Michael, additional, Kong, Andy, additional, Sethuraman, Sunantha, additional, Avtonomov, Dmitry M., additional, Ao, Minghui, additional, Colaprico, Antonio, additional, Cao, Song, additional, Cho, Kyung-Cho, additional, Kalayci, Selim, additional, Ma, Shiyong, additional, Liu, Wenke, additional, Ruggles, Kelly, additional, Calinawan, Anna, additional, Gümüş, Zeynep H., additional, Geiszler, Daniel, additional, Kawaler, Emily, additional, Teo, Guo Ci, additional, Wen, Bo, additional, Zhang, Yuping, additional, Keegan, Sarah, additional, Li, Kai, additional, Chen, Feng, additional, Edwards, Nathan, additional, Pierorazio, Phillip M., additional, Chen, Xi Steven, additional, Pavlovich, Christian P., additional, Hakimi, A. Ari, additional, Brominski, Gabriel, additional, Hsieh, James J., additional, Antczak, Andrzej, additional, Omelchenko, Tatiana, additional, Lubinski, Jan, additional, Wiznerowicz, Maciej, additional, Linehan, W. Marston, additional, Kinsinger, Christopher R., additional, Thiagarajan, Mathangi, additional, Boja, Emily S., additional, Mesri, Mehdi, additional, Hiltke, Tara, additional, Robles, Ana I., additional, Rodriguez, Henry, additional, Qian, Jiang, additional, Fenyö, David, additional, Zhang, Bing, additional, Ding, Li, additional, Schadt, Eric, additional, Chinnaiyan, Arul M., additional, Zhang, Zhen, additional, Omenn, Gilbert S., additional, Cieslik, Marcin, additional, Chan, Daniel W., additional, Nesvizhskii, Alexey I., additional, Wang, Pei, additional, Zhang, Hui, additional, Hashimi, Abdul Samad, additional, Pico, Alexander R., additional, Karpova, Alla, additional, Charamut, Alyssa, additional, Paulovich, Amanda G., additional, Perou, Amy M., additional, Malovannaya, Anna, additional, Marrero-Oliveras, Annette, additional, Agarwal, Anupriya, additional, Hindenach, Barbara, additional, Pruetz, Barbara, additional, Kim, Beom-Jun, additional, Druker, Brian J., additional, Newton, Chelsea J., additional, Birger, Chet, additional, Jones, Corbin D., additional, Tognon, Cristina, additional, Mani, D.R., additional, Valley, Dana R., additional, Rohrer, Daniel C., additional, Zhou, Daniel C., additional, Tansil, Darlene, additional, Chesla, David, additional, Heiman, David, additional, Wheeler, David, additional, Tan, Donghui, additional, Chan, Doug, additional, Demir, Emek, additional, Malc, Ewa, additional, Modugno, Francesmary, additional, Getz, Gaddy, additional, Hostetter, Galen, additional, Wilson, George D., additional, Hart, Gerald W., additional, Zhu, Heng, additional, Liu, Hongwei, additional, Culpepper, Houston, additional, Sun, Hua, additional, Zhou, Hua, additional, Day, Jacob, additional, Suh, James, additional, Huang, Jasmine, additional, McDermott, Jason, additional, Whiteaker, Jeffrey R., additional, Tyner, Jeffrey W., additional, Eschbacher, Jennifer, additional, Chen, Jin, additional, McGee, John, additional, Zhu, Jun, additional, Ketchum, Karen A., additional, Rodland, Karin D., additional, Clauser, Karl, additional, Robinson, Karna, additional, Krug, Karsten, additional, Hoadley, Katherine A., additional, Um, Ki Sung, additional, Elburn, Kim, additional, Holloway, Kimberly, additional, Wang, Liang-Bo, additional, Blumenberg, Lili, additional, Hannick, Linda, additional, Qi, Liqun, additional, Sokoll, Lori J., additional, Cornwell, MacIntosh, additional, Loriaux, Marc, additional, Domagalski, Marcin J., additional, Gritsenko, Marina A., additional, Anderson, Matthew, additional, Monroe, Matthew E., additional, Ellis, Matthew J., additional, Dyer, Maureen, additional, Anurag, Meenakshi, additional, Burke, Meghan C., additional, Borucki, Melissa, additional, Gillette, Michael A., additional, Birrer, Michael J., additional, Lewis, Michael, additional, Ittmann, Michael M., additional, Smith, Michael, additional, Vernon, Michael, additional, Chaikin, Michelle, additional, Chheda, Milan G., additional, Khan, Munziba, additional, Roche, Nancy, additional, Edwards, Nathan J., additional, Vatanian, Negin, additional, Tignor, Nicole, additional, Beckmann, Noam, additional, Grady, Pamela, additional, Castro, Patricia, additional, Piehowski, Paul, additional, McGarvey, Peter B., additional, Mieczkowski, Piotr, additional, Hariharan, Pushpa, additional, Gao, Qingsong, additional, Dhir, Rajiv, additional, Kothadia, Ramani Bhupendra, additional, Thangudu, Ratna R., additional, Montgomery, Rebecca, additional, Jayasinghe, Reyka G., additional, Smith, Richard D., additional, Edwards, Robert, additional, Zelt, Robert, additional, Bremner, Ross, additional, Liu, Ruiyang, additional, Hong, Runyu, additional, Mareedu, Sailaja, additional, Payne, Samuel H., additional, Cottingham, Sandra, additional, Markey, Sanford P., additional, Jewell, Scott D., additional, Patel, Shalin, additional, Satpathy, Shankha, additional, Richey, Shannon, additional, Davies, Sherri R., additional, Cai, Shuang, additional, Boca, Simina M., additional, Patil, Snehal, additional, Sengupta, Sohini, additional, Carter, Sonya, additional, Gabriel, Stacey, additional, Thomas, Stefani N., additional, De Young, Stephanie, additional, Stein, Stephen E., additional, Carr, Steven A., additional, Foltz, Steven M., additional, Hilsenbeck, Sue, additional, Krubit, Tanya, additional, Liu, Tao, additional, Skelly, Tara, additional, Westbrook, Thomas, additional, Borate, Uma, additional, Velvulou, Uma, additional, Petyuk, Vladislav A., additional, Bocik, William E., additional, Chen, Xi, additional, Shi, Yan, additional, Geffen, Yifat, additional, Lu, Yihao, additional, Wang, Ying, additional, Maruvka, Yosef, additional, Li, Zhi, additional, Shi, Zhiao, additional, and Tu, Zhidong, additional

Published
2020
Full Text
View/download PDF

47. Dissecting the Structural Dynamics of the Nuclear Pore Complex

Author

Hakhverdyan, Zhanna, primary, Molloy, Kelly R., additional, Keegan, Sarah, additional, Lepore, Dante M., additional, Munson, Mary, additional, Subbotin, Roman I., additional, Fenyo, David, additional, Fernandez-Martinez, Javier, additional, Chait, Brian T., additional, and Rout, Michael P., additional

Published
2020
Full Text
View/download PDF

48. Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

Author

Clark, David J., primary, Dhanasekaran, Saravana M., additional, Petralia, Francesca, additional, Pan, Jianbo, additional, Song, Xiaoyu, additional, Hu, Yingwei, additional, da Veiga Leprevost, Felipe, additional, Reva, Boris, additional, Lih, Tung-Shing M., additional, Chang, Hui-Yin, additional, Ma, Weiping, additional, Huang, Chen, additional, Ricketts, Christopher J., additional, Chen, Lijun, additional, Krek, Azra, additional, Li, Yize, additional, Rykunov, Dmitry, additional, Li, Qing Kay, additional, Chen, Lin S., additional, Ozbek, Umut, additional, Vasaikar, Suhas, additional, Wu, Yige, additional, Yoo, Seungyeul, additional, Chowdhury, Shrabanti, additional, Wyczalkowski, Matthew A., additional, Ji, Jiayi, additional, Schnaubelt, Michael, additional, Kong, Andy, additional, Sethuraman, Sunantha, additional, Avtonomov, Dmitry M., additional, Ao, Minghui, additional, Colaprico, Antonio, additional, Cao, Song, additional, Cho, Kyung-Cho, additional, Kalayci, Selim, additional, Ma, Shiyong, additional, Liu, Wenke, additional, Ruggles, Kelly, additional, Calinawan, Anna, additional, Gümüş, Zeynep H., additional, Geiszler, Daniel, additional, Kawaler, Emily, additional, Teo, Guo Ci, additional, Wen, Bo, additional, Zhang, Yuping, additional, Keegan, Sarah, additional, Li, Kai, additional, Chen, Feng, additional, Edwards, Nathan, additional, Pierorazio, Phillip M., additional, Chen, Xi Steven, additional, Pavlovich, Christian P., additional, Hakimi, A. Ari, additional, Brominski, Gabriel, additional, Hsieh, James J., additional, Antczak, Andrzej, additional, Omelchenko, Tatiana, additional, Lubinski, Jan, additional, Wiznerowicz, Maciej, additional, Linehan, W. Marston, additional, Kinsinger, Christopher R., additional, Thiagarajan, Mathangi, additional, Boja, Emily S., additional, Mesri, Mehdi, additional, Hiltke, Tara, additional, Robles, Ana I., additional, Rodriguez, Henry, additional, Qian, Jiang, additional, Fenyö, David, additional, Zhang, Bing, additional, Ding, Li, additional, Schadt, Eric, additional, Chinnaiyan, Arul M., additional, Zhang, Zhen, additional, Omenn, Gilbert S., additional, Cieslik, Marcin, additional, Chan, Daniel W., additional, Nesvizhskii, Alexey I., additional, Wang, Pei, additional, Zhang, Hui, additional, Hashimi, Abdul Samad, additional, Pico, Alexander R., additional, Karpova, Alla, additional, Charamut, Alyssa, additional, Paulovich, Amanda G., additional, Perou, Amy M., additional, Malovannaya, Anna, additional, Marrero-Oliveras, Annette, additional, Agarwal, Anupriya, additional, Hindenach, Barbara, additional, Pruetz, Barbara, additional, Kim, Beom-Jun, additional, Druker, Brian J., additional, Newton, Chelsea J., additional, Birger, Chet, additional, Jones, Corbin D., additional, Tognon, Cristina, additional, Mani, D.R., additional, Valley, Dana R., additional, Rohrer, Daniel C., additional, Zhou, Daniel C., additional, Tansil, Darlene, additional, Chesla, David, additional, Heiman, David, additional, Wheeler, David, additional, Tan, Donghui, additional, Chan, Doug, additional, Demir, Emek, additional, Malc, Ewa, additional, Modugno, Francesmary, additional, Getz, Gaddy, additional, Hostetter, Galen, additional, Wilson, George D., additional, Hart, Gerald W., additional, Zhu, Heng, additional, Liu, Hongwei, additional, Culpepper, Houston, additional, Sun, Hua, additional, Zhou, Hua, additional, Day, Jacob, additional, Suh, James, additional, Huang, Jasmine, additional, McDermott, Jason, additional, Whiteaker, Jeffrey R., additional, Tyner, Jeffrey W., additional, Eschbacher, Jennifer, additional, Chen, Jin, additional, McGee, John, additional, Zhu, Jun, additional, Ketchum, Karen A., additional, Rodland, Karin D., additional, Clauser, Karl, additional, Robinson, Karna, additional, Krug, Karsten, additional, Hoadley, Katherine A., additional, Um, Ki Sung, additional, Elburn, Kim, additional, Holloway, Kimberly, additional, Wang, Liang-Bo, additional, Blumenberg, Lili, additional, Hannick, Linda, additional, Qi, Liqun, additional, Sokoll, Lori J., additional, Cornwell, MacIntosh, additional, Loriaux, Marc, additional, Domagalski, Marcin J., additional, Gritsenko, Marina A., additional, Anderson, Matthew, additional, Monroe, Matthew E., additional, Ellis, Matthew J., additional, Dyer, Maureen, additional, Anurag, Meenakshi, additional, Burke, Meghan C., additional, Borucki, Melissa, additional, Gillette, Michael A., additional, Birrer, Michael J., additional, Lewis, Michael, additional, Ittmann, Michael M., additional, Smith, Michael, additional, Vernon, Michael, additional, Chaikin, Michelle, additional, Chheda, Milan G., additional, Khan, Munziba, additional, Roche, Nancy, additional, Edwards, Nathan J., additional, Vatanian, Negin, additional, Tignor, Nicole, additional, Beckmann, Noam, additional, Grady, Pamela, additional, Castro, Patricia, additional, Piehowski, Paul, additional, McGarvey, Peter B., additional, Mieczkowski, Piotr, additional, Hariharan, Pushpa, additional, Gao, Qingsong, additional, Dhir, Rajiv, additional, Kothadia, Ramani Bhupendra, additional, Thangudu, Ratna R., additional, Montgomery, Rebecca, additional, Jayasinghe, Reyka G., additional, Smith, Richard D., additional, Edwards, Robert, additional, Zelt, Robert, additional, Bremner, Ross, additional, Liu, Ruiyang, additional, Hong, Runyu, additional, Mareedu, Sailaja, additional, Payne, Samuel H., additional, Cottingham, Sandra, additional, Markey, Sanford P., additional, Jewell, Scott D., additional, Patel, Shalin, additional, Satpathy, Shankha, additional, Richey, Shannon, additional, Davies, Sherri R., additional, Cai, Shuang, additional, Boca, Simina M., additional, Patil, Snehal, additional, Sengupta, Sohini, additional, Carter, Sonya, additional, Gabriel, Stacey, additional, Thomas, Stefani N., additional, De Young, Stephanie, additional, Stein, Stephen E., additional, Carr, Steven A., additional, Foltz, Steven M., additional, Hilsenbeck, Sue, additional, Krubit, Tanya, additional, Liu, Tao, additional, Skelly, Tara, additional, Westbrook, Thomas, additional, Borate, Uma, additional, Velvulou, Uma, additional, Petyuk, Vladislav A., additional, Bocik, William E., additional, Chen, Xi, additional, Shi, Yan, additional, Geffen, Yifat, additional, Lu, Yihao, additional, Wang, Ying, additional, Maruvka, Yosef, additional, Li, Zhi, additional, Shi, Zhiao, additional, and Tu, Zhidong, additional

Published
2019
Full Text
View/download PDF

49. CRL4AMBRA1 is a master regulator of D-type cyclins.

Author

Simoneschi, Daniele, Rona, Gergely, Zhou, Nan, Jeong, Yeon-Tae, Jiang, Shaowen, Milletti, Giacomo, Arbini, Arnaldo A., O’Sullivan, Alfie, Wang, Andrew A., Nithikasem, Sorasicha, Keegan, Sarah, Siu, Yik, Cianfanelli, Valentina, Maiani, Emiliano, Nazio, Francesca, Cecconi, Francesco, Boccalatte, Francesco, Fenyö, David, Jones, Drew R., and Busino, Luca

Abstract

D-type cyclins are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer1, but the mechanisms that regulate their turnover are still being debated2,3. Here, by combining biochemical and genetics studies in somatic cells, we identify CRL4AMBRA1 (also known as CRL4DCAF3) as the ubiquitin ligase that targets all three D-type cyclins for degradation. During development, loss of Ambra1 induces the accumulation of D-type cyclins and retinoblastoma (RB) hyperphosphorylation and hyperproliferation, and results in defects of the nervous system that are reduced by treating pregnant mice with the FDA-approved CDK4 and CDK6 (CDK4/6) inhibitor abemaciclib. Moreover, AMBRA1 acts as a tumour suppressor in mouse models and low AMBRA1 mRNA levels are predictive of poor survival in cancer patients. Cancer hotspot mutations in D-type cyclins abrogate their binding to AMBRA1 and induce their stabilization. Finally, a whole-genome, CRISPR–Cas9 screen identified AMBRA1 as a regulator of the response to CDK4/6 inhibition. Loss of AMBRA1 reduces sensitivity to CDK4/6 inhibitors by promoting the formation of complexes of D-type cyclins with CDK2. Collectively, our results reveal the molecular mechanism that controls the stability of D-type cyclins during cell-cycle progression, in development and in human cancer, and implicate AMBRA1 as a critical regulator of the RB pathway.Biochemical and genetics studies identify CRL4AMBRA1 as the ubiquitin ligase that has a key role in regulating the stability of D-type cyclins during cell-cycle progression. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results