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2. Reevaluation of the Premier Clostridium difficile toxin A and B immunoassay with comparison to glutamate dehydrogenase common antigen testing evaluating Bartels cytotoxin and Prodesse ProGastro™ Cd polymerase chain reaction as confirmatory procedures

Author

Doing, Kirk M., Hintz, Marilyn S., Keefe, Calvin, Horne, Sarah, LeVasseur, Shelby, and Kulikowski, Martha L.

Subjects
*ENZYME-linked immunosorbent assay, *MICROBIAL sensitivity tests, *CLOSTRIDIOIDES difficile, *OXIDOREDUCTASES, *BACTERIAL toxins, *MEDICAL technologists, *DIAGNOSTIC use of polymerase chain reaction
Abstract

Abstract: Enzyme immunoassays are currently the most common tests used in the clinical laboratory for the detection of Clostridium difficile toxins; however, significant problems with their performance have recently been described. We prospectively reevaluated the Meridian Premier C. difficile toxin A/B assay with direct comparison to a 2-step algorithm that screened for C. difficile common antigen and compared cytotoxin and real-time polymerase chain reaction (PCR) as confirmatory procedures. The Premier assay lacked sufficient sensitivity, missing 25% of true-positive samples. PCR was the most sensitive method and the only procedure that allowed same day testing and reporting. [Copyright &y& Elsevier]

Published
2010
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