36 results on '"Keeble, E."'
Search Results
2. Husbandry risk factors associated with hock pododermatitis in UK pet rabbits (Oryctolagus cuniculus)
- Author
-
Mancinelli, E., Keeble, E., Richardson, J., and Hedley, J.
- Published
- 2014
- Full Text
- View/download PDF
3. Femoral condylar fractures in four continental giant breed rabbits.
- Author
-
Dorlis, C., Garcia‐Pertierra, S., Richardson, J., Koterwas, B., Keeble, E., Eatwell, K., Ryan, J., and Clements, D. N.
- Subjects
FEMORAL fractures ,RABBIT breeding ,FRACTURE fixation ,SURGICAL complications ,RABBITS - Abstract
Four male neutered continental giant rabbits aged between 10 and 30 months were presented with femoral condylar fractures, which developed without an observed traumatic injury. Stabilisation of the condylar fracture was achieved with screw fixation in all cases, which was supplemented with additional fixation in three cases. Complications consequent to the surgical intervention occurred in two cases: a femoral fracture and loss of fixation. Three rabbits were reported to have recovered normal limb function, and the rabbit that developed a femoral fracture as a consequence of its surgical intervention was treated with amputation. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
4. Medical management of Trichophyton dermatophytosis using a novel treatment regimen in LʼHoestʼs monkeys (Cercopithecus lhoesti)
- Author
-
Keeble, E. J., Neuber, A., Hume, L., and Goodman, G.
- Published
- 2010
- Full Text
- View/download PDF
5. Presentation, treatment and outcome of long‐bone fractures in pet rabbits (Oryctolagus cuniculus)
- Author
-
Garcia‐Pertierra, S., primary, Ryan, J., additional, Richardson, J., additional, Koterwas, B., additional, Keeble, E., additional, Eatwell, K., additional, and Clements, D. N., additional
- Published
- 2019
- Full Text
- View/download PDF
6. Re-admission patterns in England and the Netherlands: a comparison based on administrative data of all hospitals
- Author
-
Hekkert, K.D., Brug, F. van der, Keeble, E., Borghans, I., Cihangir, S., Bardsley, M., Clarke, A., Westert, G.P., Kool, R.B., Hekkert, K.D., Brug, F. van der, Keeble, E., Borghans, I., Cihangir, S., Bardsley, M., Clarke, A., Westert, G.P., and Kool, R.B.
- Abstract
Contains fulltext : 202264.pdf (publisher's version ) (Closed access), BACKGROUND: Examining variation in patterns of re-admissions between countries can be valuable for mutual learning in order to reduce unnecessary re-admissions. The aim of this study was to compare re-admission rates and reasons for re-admissions between England and the Netherlands. METHODS: We used data from 85 Dutch hospitals (1 355 947 admissions) and 451 English hospitals (5 260 227 admissions) in 2014 (96% of all Dutch hospitals and 100% of all English NHS hospitals). Re-admission data from England and the Netherlands were compared for all hospital patients and for specific diagnosis groups: pneumonia, urinary tract infection, chronic obstructive pulmonary disease, coronary atherosclerosis, biliary tract disease, hip fracture and acute myocardial infarction. Re-admissions were categorized using a classification system developed on administrative data. The classification distinguishes between potentially preventable re-admissions and other reasons for re-admission. RESULTS: England had a higher 30-day re-admission rate (adjusted for age and gender) compared to the Netherlands: 11.17% (95% CI 11.14-11.20%) vs. 9.83% (95% CI 9.77-9.88%). The main differences appeared to be in re-admissions for the elderly (England 17.2% vs. the Netherlands 10.0%) and in emergency re-admissions (England 85.3% of all 30-day re-admissions vs. the Netherlands 66.8%). In the Netherlands, however, more emergency re-admissions were classified as potentially preventable compared to England (33.8% vs. 28.8%). CONCLUSIONS: The differences found between England and the Netherlands indicate opportunities to reduce unnecessary re-admissions. For England this concerns more expanded palliative care, integrated social care and reduction of waiting times. In the Netherlands, the use of treatment plans for daily life could be increased.
- Published
- 2019
7. Optimisation of Urban Layout with Respect to Solar Irradiation
- Author
-
Peckham, R. J., primary and Keeble, E. J., additional
- Published
- 1990
- Full Text
- View/download PDF
8. Presentation, treatment and outcome of long‐bone fractures in pet rabbits (Oryctolagus cuniculus).
- Author
-
Garcia‐Pertierra, S., Ryan, J., Richardson, J., Koterwas, B., Keeble, E., Eatwell, K., and Clements, D. N.
- Subjects
BONE fractures in animals ,EUROPEAN rabbit ,HEALTH of pets ,DIAGNOSIS of bone fractures ,BONE fractures -- Prognosis - Abstract
The article focuses on long-bone fractures in pet rabbits (Oryctolagus cuniculus). According to the article, 2,457 rabbits were examined over a period of 12 years at one institution in Great Britain. Records of diagnosis, treatment, complications, and prognosis of fractured bones including femoral, fibula, and ulna are analyzed.
- Published
- 2020
- Full Text
- View/download PDF
9. Family Record of Henry St. John Clark, 1690
- Author
-
Keeble, E. F.
- Published
- 1914
- Full Text
- View/download PDF
10. Partial ear canal ablation and lateral bulla osteotomy in rabbits
- Author
-
Eatwell, K., primary, Mancinelli, E., additional, Hedley, J., additional, Keeble, E., additional, Kovalik, M., additional, and Yool, D. A., additional
- Published
- 2013
- Full Text
- View/download PDF
11. Seroprevalence of antibodies to Encephalitozoon cuniculi in domestic rabbits in the United Kingdom
- Author
-
Keeble, E. J., primary and Shaw, D. J., additional
- Published
- 2006
- Full Text
- View/download PDF
12. Pieris japonica intoxication in an African spurred tortoise (Geochelone sulcata)
- Author
-
Pizzi, R., primary, Goodman, G., additional, Gunn‐Moore, D., additional, Meredith, A., additional, and Keeble, E., additional
- Published
- 2005
- Full Text
- View/download PDF
13. Dry-bulb temperature analyses for climate change at three UK sites in relation to the forthcoming CIBSE Guide to weather and solar data
- Author
-
Levermore, G.J., primary and Keeble, E., additional
- Published
- 1998
- Full Text
- View/download PDF
14. South American camelids in the United Kingdom: population statistics, mortality rates and causes of death
- Author
-
Davis, R., primary, Keeble, E., additional, Wright, A., additional, and Morgan, K. L., additional
- Published
- 1998
- Full Text
- View/download PDF
15. Family Record of Henry St. John Clark, 1690
- Author
-
Keeble, E. F., primary
- Published
- 1914
- Full Text
- View/download PDF
16. III. Observations on the Loranthaceae of Ceylon.
- Author
-
Keeble, E. W., primary
- Published
- 1896
- Full Text
- View/download PDF
17. Computed tomographic features of the normal spleen in rabbits (Oryctolagus cuniculus domesticus).
- Author
-
Chernev C, Procter T, Isaac I, Koterwas B, Eatwell K, Keeble E, Richardson J, and Schwarz T
- Subjects
- Rabbits, Animals, Retrospective Studies, Abdomen, Body Weight, Spleen diagnostic imaging, Tomography, X-Ray Computed veterinary, Tomography, X-Ray Computed methods
- Abstract
Computed tomography is commonly utilized for investigation of rabbits, and more recently, for evaluating abdominal pathology. The spleen, however, is an often-overlooked organ, with limited information published. The aims of this retrospective, observational, study were to document the visibility, size, and shape of the normal rabbit spleen and potential correlations with signalment. Institutional imaging archives were reviewed for diagnostic-image-quality abdominal CT studies of rabbits. In 115 cases, the inclusion criteria were met. Pre- and postcontrast CT studies were evaluated by two reviewers for visibility of the spleen. For precontrast CT images, the interrater agreement for identification of the spleen was fair. For postcontrast CT images, interrater agreement was moderate. There were significantly more spleens clearly identified on postcontrast studies compared with precontrast CT. Splenic location, volume, shape, X-ray attenuation, and length were measured, and the splenic-volume-to-body-weight ratio was calculated. The mean splenic volume was 1 mL (range 0.2-3.9 mL), mean length 40 mm (range 20-61 mm), mean attenuation (precontrast CT 80 HU and postcontrast CT 320 HU), and mean splenic volume/body weight ratio was 0.5 mL/kg (range 0.17-1.2 mL/kg). There was a significant relationship between splenic volume and body weight, which was weakly positively correlated. There was no correlation between splenic volume, age, and sex. The most commonly identified splenic shapes were "banana", "tongue", and "elephant trunk". The rabbit spleen can be identified on CT images, but more reliably on postcontrast CT images, which underlines the usefulness of contrast-enhanced CT in this species., (© 2023 The Authors. Veterinary Radiology & Ultrasound published by Wiley Periodicals LLC on behalf of American College of Veterinary Radiology.)
- Published
- 2023
- Full Text
- View/download PDF
18. External validation of the Hospital Frailty Risk Score in France.
- Author
-
Gilbert T, Cordier Q, Polazzi S, Bonnefoy M, Keeble E, Street A, Conroy S, and Duclos A
- Subjects
- Aged, Hospitals, Humans, Length of Stay, Retrospective Studies, Risk Factors, Frailty diagnosis, Frailty epidemiology
- Abstract
Background: The Hospital Frailty Risk Score (HFRS) has made it possible internationally to identify subgroups of patients with characteristics of frailty from routinely collected hospital data., Objective: To externally validate the HFRS in France., Design: A retrospective analysis of the French medical information database., Setting: 743 hospitals in Metropolitan France., Subjects: All patients aged 75 years or older hospitalised as an emergency in 2017 (n = 1,042,234)., Methods: The HFRS was calculated for each patient based on the index stay and hospitalisations over the preceding 2 years. Main outcome measures were 30-day in-patient mortality, length of stay (LOS) >10 days and 30-day readmissions. Mixed logistic regression models were used to investigate the association between outcomes and HFRS score., Results: Patients with high HFRS risk were associated with increased risk of mortality and prolonged LOS (adjusted odds ratio [aOR] = 1.38 [1.35-1.42] and 3.27 [3.22-3.32], c-statistics = 0.676 and 0.684, respectively), while it appeared less predictive of readmissions (aOR = 1.00 [0.98-1.02], c-statistic = 0.600). Model calibration was excellent. Restricting the score to data prior to index admission reduced discrimination of HFRS substantially., Conclusions: HFRS can be used in France to determine risks of 30-day in-patient mortality and prolonged LOS, but not 30-day readmissions. Trial registration: Reference ID on clinicaltrials.gov: ID: NCT03905629., (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2022
- Full Text
- View/download PDF
19. Are the needs of people with multiple long-term conditions being met? Evidence from the 2018 General Practice Patient Survey.
- Author
-
Rolewicz L, Keeble E, Paddison C, and Scobie S
- Subjects
- Activities of Daily Living, Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, England, Female, Health Services Needs and Demand, Humans, Male, Middle Aged, Surveys and Questionnaires, Young Adult, General Practice
- Abstract
Objectives: To investigate individual, practice and area level variation in patient-reported unmet need among those with long-term conditions, in the context of general practice (GP) appointments and support from community-based services in England., Design: Cross-sectional study using data from 199 150 survey responses., Setting: Primary care and community-based services., Participants: Respondents to the 2018 English General Practice Patient Survey with at least one long-term condition., Primary and Secondary Outcome Measures: The primary outcomes were the levels of unmet need in GP and local services among patients with multiple long-term conditions. Secondary outcomes were the proportion of variation explained by practice and area-level factors., Results: There was no relationship between needs being fully met in patients' last practice appointment and number of long-term conditions once sociodemographic characteristics and health status were taken into account (5+conditions-OR=1.04, 95% CI 0.99 to 1.09), but there was a relationship for having enough support from local services to manage conditions (5+conditions-OR=0.84, 95% CI 0.80 to 0.88). Patients with multimorbidity that were younger, non-white or frail were less likely to have their needs fully met, both in GP and from local services. Differences between practices and local authorities explained minimal variation in unmet need., Conclusions: Levels of unmet need are high, particularly for support from community services to manage multiple conditions. Patients who could be targeted for support include people who feel socially isolated, and those who have difficulties with their day-to-day living. Younger patients and certain ethnic groups with multimorbidity are also more likely to have unmet needs. Increased personalisation and coordination of care among these groups may help in addressing their needs., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2020
- Full Text
- View/download PDF
20. Selected Emerging Diseases of Pet Hedgehogs.
- Author
-
Keeble E and Koterwas B
- Subjects
- Animals, Brain Neoplasms epidemiology, Communicable Diseases, Emerging epidemiology, Female, Mite Infestations epidemiology, Brain Neoplasms veterinary, Communicable Diseases, Emerging veterinary, Hedgehogs, Mite Infestations veterinary, Psoroptidae physiology
- Abstract
Pet hedgehog medicine and surgery is a rapidly evolving field, with some novel conditions and re-emerging diseases being reported in the literature in recent years. Skin disease and neoplasia are commonly found in African pygmy hedgehogs worldwide. Selected new and emerging diseases occurring in these commonly reported groups are discussed in greater detail, focusing on Caparinia tripilis infestation and brain tumors. This article primarily discusses African pygmy hedgehogs, with some reference to European free-living hedgehogs., Competing Interests: Disclosure The authors have nothing to disclose., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
21. Salmonellosis in Hedgehogs.
- Author
-
Keeble E and Koterwas B
- Subjects
- Animals, Humans, Salmonella Infections, Animal drug therapy, Salmonella Infections, Animal pathology, Salmonella Infections, Animal prevention & control, Zoonoses, Hedgehogs microbiology, Salmonella Infections, Animal diagnosis
- Abstract
African pygmy hedgehogs are popular pets worldwide. The knowledge and understanding of pet hedgehog common veterinary conditions are increasing as new information and research are published; however, there is still much to learn about this fascinating animal. Salmonella is one of the most common zoonoses worldwide and is naturally isolated from the intestinal tract of many animal species, including hedgehogs. This article discusses the cause, clinical signs, diagnosis, treatment, and prevention of salmonella infection in hedgehogs, primarily focusing on African pygmy hedgehogs, with some reference to European hedgehogs., Competing Interests: Disclosure The authors have nothing to disclose., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
22. Frailty, hospital use and mortality in the older population: findings from the Newcastle 85+ study.
- Author
-
Keeble E, Parker SG, Arora S, Neuburger J, Duncan R, Kingston A, Hanratty B, Jagger C, Robinson L, and Kirkwood T
- Subjects
- Aged, 80 and over, England epidemiology, Female, Frail Elderly statistics & numerical data, Frailty epidemiology, Hospital Costs statistics & numerical data, Humans, Kaplan-Meier Estimate, Male, Patient Acceptance of Health Care statistics & numerical data, Proportional Hazards Models, Prospective Studies, Frailty mortality, Hospitalization statistics & numerical data
- Abstract
Background: Frailty is a significant determinant of health care utilisation and associated costs, both of which also increase with proximity to death. What is not known is how the relationships between frailty, proximity to death, hospital use and costs develop in a population aged 85 years and over., Methods: This study used data from a prospective observational cohort, the Newcastle 85+ Study, linked with hospital episode statistics and death registrations. Using the Rockwood frailty index (cut off <0.25), we analysed the relationship between frailty and mortality, proximity to death, hospital use and hospital costs over 2, 5 and 7 years using descriptive statistics, Kaplan-Meier survival curves, Cox's proportional hazards and negative binomial regression models., Results: Baseline frailty was associated with a more than two-fold increased risk of mortality after 7 years, compared to people who were non-frail. Participants classified as frail spent more time in hospital over 7 years than the non-frail, but this difference declined over time. Baseline frailty was not associated with increased time spent in hospital during the last 90 days of life., Conclusion: Evidence continues to accrue on the impact of frailty on emergency health care use. Hospital and community services need to adapt to meet the challenge of introducing new proactive and preventative approaches, designed to achieve benefits in clinical and/or cost effectiveness of frailty management., (© The Author(s) 2019. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2019
- Full Text
- View/download PDF
23. Area level impacts on emergency hospital admissions of the integrated care and support pioneer programme in England: difference-in-differences analysis.
- Author
-
Keeble E, Bardsley M, Durand MA, Hoomans T, and Mays N
- Subjects
- Emergencies epidemiology, England epidemiology, Female, Health Policy, Hospitalization statistics & numerical data, Humans, Male, Middle Aged, Organizational Innovation, Patient Admission statistics & numerical data, Regional Medical Programs organization & administration, Delivery of Health Care, Integrated organization & administration, Delivery of Health Care, Integrated standards, Demography, Emergency Service, Hospital statistics & numerical data, Social Work methods, Social Work standards
- Abstract
Objective: To examine whether any differential change in emergency admissions could be attributed to integrated care by comparing pioneer and non-pioneer populations from a pre-pioneer baseline period (April 2010 to March 2013) over two follow-up periods: to 2014/2015 and to 2015/2016., Design: Difference-in-differences analysis of emergency hospital admissions from English Hospital Episode Statistics., Setting: Local authorities in England classified as either pioneer or non-pioneer., Participants: Emergency admissions to all NHS hospitals in England with local authority determined by area of residence of the patient., Intervention: Wave 1 of the integrated care and support pioneer programme announced in November 2013., Primary Outcome Measure: Change in hospital emergency admissions., Results: The increase in the pioneer emergency admission rate from baseline to 2014/2015 was smaller at 1.93% and significantly different from that of the non-pioneers at 4.84% (p=0.0379). The increase in the pioneer emergency admission rate from baseline to 2015/2016 was again smaller than for the non-pioneers but the difference was not statistically significant (p=0.1879)., Conclusions: It is ambitious to expect unequivocal changes in a high level and indirect indicator of health and social care integration such as emergency hospital admissions to arise as a result of the changes in local health and social care provision across organisations brought about by the pioneers in their early years. We should treat any sign that the pioneers have had such an impact with caution. Nevertheless, there does seem to be an indication from the current analysis that there were some changes in hospital use associated with the first year of pioneer status that are worthy of further exploration., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.)
- Published
- 2019
- Full Text
- View/download PDF
24. Outcomes of hospital admissions among frail older people: a 2-year cohort study.
- Author
-
Keeble E, Roberts HC, Williams CD, Van Oppen J, and Conroy SP
- Subjects
- Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Male, Outcome Assessment, Health Care, Frail Elderly, Geriatric Assessment statistics & numerical data, Hospitalization statistics & numerical data, Length of Stay statistics & numerical data
- Abstract
Background: 'Frailty crises' are a common cause of hospital admission among older people and there is significant focus on admission avoidance. However, identifying frailty before a crisis occurs is challenging, making it difficult to effectively target community services. Better longer-term outcome data are needed if services are to reflect the needs of the growing population of older people with frailty., Aim: To determine long-term outcomes of older people discharged from hospital following short (<72 hours) and longer hospital admissions compared by frailty status., Design and Setting: Two populations aged ≥70 years discharged from hospital units: those following short 'ambulatory' admissions (<72 hours) and those following longer inpatient stays., Method: Data for 2-year mortality and hospital use were compared using frailty measures derived from clinical and hospital data., Results: Mortality after 2 years was increased for frail compared with non-frail individuals in both cohorts. Patients in the ambulatory cohort classified as frail had increased mortality (Rockwood hazard ratio 2.3 [95% confidence interval {CI} = 1.5 to 3.4]) and hospital use (Rockwood rate ratio 2.1 [95% CI = 1.7 to 2.6]) compared with those patients classified as non-frail., Conclusion: Individuals with frailty who are discharged from hospital experience increased mortality and resource use, even after short 'ambulatory' admissions. This is an easily identifiable group that is at increased risk of poor outcomes. Health and social care systems might wish to examine their current care response for frail older people discharged from hospital. There may be value in a 'secondary prevention' approach to frailty crises targeting individuals who are discharged from hospital., (© British Journal of General Practice 2019.)
- Published
- 2019
- Full Text
- View/download PDF
25. Re-admission patterns in England and the Netherlands: a comparison based on administrative data of all hospitals.
- Author
-
Hekkert K, van der Brug F, Keeble E, Borghans I, Cihangir S, Bardsley M, Clarke A, Westert GP, and Kool RB
- Subjects
- Adolescent, Adult, Age Factors, Aged, Child, Child, Preschool, Cross-Cultural Comparison, Diagnosis-Related Groups, Emergency Service, Hospital statistics & numerical data, England, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Netherlands, Sex Factors, Young Adult, Hospital Administration statistics & numerical data, Patient Readmission statistics & numerical data, State Medicine statistics & numerical data
- Abstract
Background: Examining variation in patterns of re-admissions between countries can be valuable for mutual learning in order to reduce unnecessary re-admissions. The aim of this study was to compare re-admission rates and reasons for re-admissions between England and the Netherlands., Methods: We used data from 85 Dutch hospitals (1 355 947 admissions) and 451 English hospitals (5 260 227 admissions) in 2014 (96% of all Dutch hospitals and 100% of all English NHS hospitals). Re-admission data from England and the Netherlands were compared for all hospital patients and for specific diagnosis groups: pneumonia, urinary tract infection, chronic obstructive pulmonary disease, coronary atherosclerosis, biliary tract disease, hip fracture and acute myocardial infarction. Re-admissions were categorized using a classification system developed on administrative data. The classification distinguishes between potentially preventable re-admissions and other reasons for re-admission., Results: England had a higher 30-day re-admission rate (adjusted for age and gender) compared to the Netherlands: 11.17% (95% CI 11.14-11.20%) vs. 9.83% (95% CI 9.77-9.88%). The main differences appeared to be in re-admissions for the elderly (England 17.2% vs. the Netherlands 10.0%) and in emergency re-admissions (England 85.3% of all 30-day re-admissions vs. the Netherlands 66.8%). In the Netherlands, however, more emergency re-admissions were classified as potentially preventable compared to England (33.8% vs. 28.8%)., Conclusions: The differences found between England and the Netherlands indicate opportunities to reduce unnecessary re-admissions. For England this concerns more expanded palliative care, integrated social care and reduction of waiting times. In the Netherlands, the use of treatment plans for daily life could be increased., (© The Author(s) 2018. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
26. Comprehensive geriatric assessment for frail older people in acute hospitals: the HoW-CGA mixed-methods study
- Author
-
Conroy SP, Bardsley M, Smith P, Neuburger J, Keeble E, Arora S, Kraindler J, Ariti C, Sherlaw-Johnson C, Street A, Roberts H, Kennedy S, Martin G, Phelps K, Regen E, Kocman D, McCue P, Fisher E, and Parker S
- Abstract
Background: The aim of this study was to provide high-quality evidence on delivering hospital-wide Comprehensive Geriatric Assessment (CGA)., Objective(s): (1) To define CGA, its processes, outcomes and costs in the published literature, (2) to identify the processes, outcomes and costs of CGA in existing hospital settings in the UK, (3) to identify the characteristics of the recipients and beneficiaries of CGA in existing hospital settings in the UK and (4) to develop tools that will assist in the implementation of hospital-wide CGA., Design: Mixed-methods study combining a mapping review, national survey, large data analysis and qualitative methods., Participants: People aged ≥ 65 years in acute hospital settings., Data Sources: Literature review – Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, MEDLINE and EMBASE. Survey – acute hospital trusts. Large data analyses – (1) people aged ≥ 75 years in 2008 living in Leicester, Nottingham or Southampton (development cohort, n = 22,139); (2) older people admitted for short stay (Nottingham/Leicester, n = 825) to a geriatric ward (Southampton, n = 246) or based in the community (Newcastle, n = 754); (3) people aged ≥ 75 years admitted to acute hospitals in England in 2014–15 (validation study, n = 1,013,590). Toolkit development – multidisciplinary national stakeholder group (co-production); field-testing with cancer/surgical teams in Newcastle/Leicester., Results: Literature search – common outcomes included clinical, operational and destinational, but not patient-reported, outcome measures. Survey – highly variable provision of multidisciplinary assessment and care across hospitals. Quantitative analyses – in the development cohort, older people with frailty diagnoses formed a distinct group and had higher non-elective hospital use than older people without a frailty diagnosis. Patients with the highest 20% of hospital frailty risk scores had increased odds of 30-day mortality [odds ratio (OR) 1.7], long length of stay (OR 6.0) and 30-day re-admission (OR 1.5). The score had moderate agreement with the Fried and Rockwood scales. Pilot toolkit evaluation – participants across sites were still at the beginning of their work to identify patients and plan change. In particular, competing definitions of the role of geriatricians were evident., Limitations: The survey was limited by an incomplete response rate but it still provides the largest description of acute hospital care for older people to date. The risk stratification tool is not contemporaneous, although it remains a powerful predictor of patient harms. The toolkit evaluation is still rather nascent and could have meaningfully continued for another year or more., Conclusions: CGA remains the gold standard approach to improving a range of outcomes for older people in acute hospitals. Older people at risk can be identified using routine hospital data. Toolkits aimed at enhancing the delivery of CGA by non-specialists can be useful but require prolonged geriatrician support and implementation phases. Future work could involve comparing the hospital-based frailty index with the electronic Frailty Index and further testing of the clinical toolkits in specialist services., Funding: The National Institute for Health Research Health Services and Delivery Research programme., (Copyright © Queen’s Printer and Controller of HMSO 2019. This work was produced by Conroy et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.)
- Published
- 2019
- Full Text
- View/download PDF
27. Development and validation of a Hospital Frailty Risk Score focusing on older people in acute care settings using electronic hospital records: an observational study.
- Author
-
Gilbert T, Neuburger J, Kraindler J, Keeble E, Smith P, Ariti C, Arora S, Street A, Parker S, Roberts HC, Bardsley M, and Conroy S
- Subjects
- Aged, Aged, 80 and over, Databases, Factual, Female, Hospitalization statistics & numerical data, Humans, Male, Predictive Value of Tests, Retrospective Studies, Risk Factors, Electronic Health Records statistics & numerical data, Frail Elderly statistics & numerical data, Geriatric Assessment methods, Outcome Assessment, Health Care
- Abstract
Background: Older people are increasing users of health care globally. We aimed to establish whether older people with characteristics of frailty and who are at risk of adverse health-care outcomes could be identified using routinely collected data., Methods: A three-step approach was used to develop and validate a Hospital Frailty Risk Score from International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) diagnostic codes. First, we carried out a cluster analysis to identify a group of older people (≥75 years) admitted to hospital who had high resource use and diagnoses associated with frailty. Second, we created a Hospital Frailty Risk Score based on ICD-10 codes that characterised this group. Third, in separate cohorts, we tested how well the score predicted adverse outcomes and whether it identified similar groups as other frailty tools., Findings: In the development cohort (n=22 139), older people with frailty diagnoses formed a distinct group and had higher non-elective hospital use (33·6 bed-days over 2 years compared with 23·0 bed-days for the group with the next highest number of bed-days). In the national validation cohort (n=1 013 590), compared with the 429 762 (42·4%) patients with the lowest risk scores, the 202 718 (20·0%) patients with the highest Hospital Frailty Risk Scores had increased odds of 30-day mortality (odds ratio 1·71, 95% CI 1·68-1·75), long hospital stay (6·03, 5·92-6·10), and 30-day readmission (1·48, 1·46-1·50). The c statistics (ie, model discrimination) between individuals for these three outcomes were 0·60, 0·68, and 0·56, respectively. The Hospital Frailty Risk Score showed fair overlap with dichotomised Fried and Rockwood scales (kappa scores 0·22, 95% CI 0·15-0·30 and 0·30, 0·22-0·38, respectively) and moderate agreement with the Rockwood Frailty Index (Pearson's correlation coefficient 0·41, 95% CI 0·38-0·47)., Interpretation: The Hospital Frailty Risk Score provides hospitals and health systems with a low-cost, systematic way to screen for frailty and identify a group of patients who are at greater risk of adverse outcomes and for whom a frailty-attuned approach might be useful., Funding: National Institute for Health Research., (Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
28. Putting rising emergency hospital admissions for children into perspective: how do international comparisons help?
- Author
-
Kossarova L and Keeble E
- Subjects
- Canada, Child, Cohort Studies, England, Humans, Infant, Hospitalization, Information Storage and Retrieval
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2018
- Full Text
- View/download PDF
29. Addressing the welfare needs of exotic pets.
- Author
-
Keeble E
- Subjects
- Animal Nutritional Physiological Phenomena, Animals, Animals, Wild, Education, Veterinary standards, Veterinary Medicine standards, Animal Husbandry education, Animal Husbandry methods, Animal Husbandry standards, Animal Welfare, Animals, Domestic physiology, Veterinary Medicine methods
- Published
- 2003
30. Encephalitozoon cuniculi in rabbits.
- Author
-
Keeble E
- Subjects
- Animals, Encephalitozoonosis diagnosis, Encephalitozoonosis epidemiology, Incidence, Seroepidemiologic Studies, United Kingdom epidemiology, Antibodies, Protozoan blood, Encephalitozoon cuniculi immunology, Encephalitozoonosis veterinary, Rabbits parasitology
- Published
- 2002
31. Encephalitozoon cuniculi in rabbits.
- Author
-
Keeble E
- Subjects
- Animals, Encephalitozoonosis diagnosis, Encephalitozoonosis epidemiology, Incidence, Prevalence, United Kingdom epidemiology, Encephalitozoon cuniculi, Encephalitozoonosis veterinary, Rabbits parasitology
- Published
- 2001
32. Confidence boost.
- Author
-
Keeble E
- Subjects
- Clinical Competence standards, Education, Nursing, Continuing, Humans, Peripheral Vascular Diseases prevention & control, Nursing Staff, Hospital education, Peripheral Vascular Diseases nursing
- Published
- 2001
- Full Text
- View/download PDF
33. Microchipping tortoises.
- Author
-
Redrobe S, Littlewood A, Divers S, Jessop M, Keeble E, Malley D, Davis RR, and Scott P
- Subjects
- Animals, Conservation of Natural Resources, Animal Welfare, Computers, Prostheses and Implants veterinary, Turtles
- Published
- 1999
34. Neutering pet rabbits.
- Author
-
Meredith A, Redrobe S, and Keeble E
- Subjects
- Animals, Animals, Domestic, Endometritis diagnosis, Female, Endometritis veterinary, Hysterectomy veterinary, Ovariectomy veterinary, Rabbits
- Published
- 1999
35. South American camelids in the United Kingdom: reproductive failure, pregnancy diagnosis and neonatal care.
- Author
-
Wright A, Davis R, Keeble E, and Morgan KL
- Subjects
- Animals, Behavior, Animal, Data Collection, Female, Infant, Newborn, Pregnancy, Pregnancy Tests veterinary, United Kingdom, Animal Husbandry, Camelus, Pregnancy Outcome veterinary, Reproduction
- Abstract
The results of a postal questionnaire survey conducted between December 1992 and March 1993 indicated that a third of mated female South American camelids in the United Kingdom failed to produce offspring. This failure did not include abortions or stillbirths, which accounted for up to 4 per cent and up to 3 per cent of further reproductive losses respectively. The most common method of pregnancy diagnosis was observation (40 to 70 per cent). Plasma progesterone estimations and ultrasonography were used by a small proportion of respondents. A combination of methods was seldom used. Between 25 and 46 per cent of camelid owners housed their animals at parturition and 50 to 82 per cent routinely dipped the navel of the newborn calf. Neonatal mortality was an important cause of loss.
- Published
- 1998
36. Suspected allergic reaction to penicillamine in mute swans.
- Author
-
Keeble E
- Subjects
- Animals, Birds, Drug Hypersensitivity veterinary, Penicillamine adverse effects
- Published
- 1997
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.