1. Serum YKL-40 Levels and White Matter Hyperintensities in Patients with Acute Ischemic Stroke
- Author
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Shi,Guomei, Ke,Dongdong, Gong,Pengyu, Yu,Peng, Zhou,Junshan, Wang,Meng, Zhang,Xiaohao, Wang,Xiaorong, Guo,Minwang, Xu,Mingyang, Zhou,Rujuan, Shi,Guomei, Ke,Dongdong, Gong,Pengyu, Yu,Peng, Zhou,Junshan, Wang,Meng, Zhang,Xiaohao, Wang,Xiaorong, Guo,Minwang, Xu,Mingyang, and Zhou,Rujuan
- Abstract
Guomei Shi,1,2,* Dongdong Ke,2,3,* Pengyu Gong,4,5 Peng Yu,2,6 Junshan Zhou,5 Meng Wang,5 Xiaohao Zhang,5 Xiaorong Wang,1,2 Minwang Guo,1,2 Mingyang Xu,1,2 Rujuan Zhou1,2 1Department of Neurology, the Taixing Peopleâs Hospital, Taixing, Jiangsu, Peopleâs Republic of China; 2Stroke Center, the Taixing Peopleâs Hospital, Taixing, Jiangsu, Peopleâs Republic of China; 3Department of Rehabilitation, the Taixing Peopleâs Hospital, Taixing, Jiangsu, Peopleâs Republic of China; 4Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, Peopleâs Republic of China; 5Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, Peopleâs Republic of China; 6Department of Radiology, the Taixing Peopleâs Hospital, Taixing, Jiangsu, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Rujuan Zhou, Tel +86-13951158499, Email zhourujuan123@163.comBackground: White matter hyperintensity (WMH) is associated with risk of acute ischemic stroke (AIS) and poor outcomes after AIS. The purpose of this prospective study was to evaluate the association between serum YKL-40 levels and WMH burden in patients with AIS.Methods: From February 2020 to March 2021, a total of 672 consecutive AIS patients with magnetic resonance imaging data were prospectively recruited form two centers. Serum YKL-40 levels were quantified using enzyme-linked immunosorbent assay. The burden of WMH was semiquantitatively measured by the Fazekas visual grading scale. According to severity of overall WMH, patients were dichotomized into noneâmild WMH group (Fazekas score 0â 2) or moderateâsevere WMH group (Fazekas score 3â 6). Besides, based on severity of periventricular WMH (PV-WMH) and deep WMH (D-WMH), patients were categorized as noneâmild (Fazekas score 0â 1) or moderateâsevere (Fazekas score 2â 3).Results: Among the 672 patients, 335 (49.9%) participants were
- Published
- 2023