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17 results on '"Ke, Hua Z."'

2. Sex Steroids and Prostaglandins in Bone Metabolism

Author

Jee, Webster S. S., Ma, Yanfei F., Li, Mei, Liang, Xiaoquang G., Lin, Baiyun Y., Li, Xiaojian J., Ke, Hua Z., Mori, Satoshi, Setterberg, Rebecca B., Kimmel, Donald B., Stock, Günter, editor, Habenicht, Ursula-F., editor, Ziegler, Reinhard, editor, Pfeilschifter, Johannes, editor, and Bräutigam, Matthias, editor

Published
1994
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10. Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

Author

Ominsky, Michael S, primary, Li, Chaoyang, additional, Li, Xiaodong, additional, Tan, Hong L, additional, Lee, Edward, additional, Barrero, Mauricio, additional, Asuncion, Franklin J, additional, Dwyer, Denise, additional, Han, Chun-Ya, additional, Vlasseros, Fay, additional, Samadfam, Rana, additional, Jolette, Jacquelin, additional, Smith, Susan Y, additional, Stolina, Marina, additional, Lacey, David L, additional, Simonet, William S, additional, Paszty, Chris, additional, Li, Gang, additional, and Ke, Hua Z, additional

Published
2011
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11. One Year of Transgenic Overexpression of Osteoprotegerin in Rats Suppressed Bone Resorption and Increased Vertebral Bone Volume, Density, and Strength

Author

Ominsky, Michael S, primary, Stolina, Marina, additional, Li, Xiaodong, additional, Corbin, Timothy J, additional, Asuncion, Franklin J, additional, Barrero, Mauricio, additional, Niu, Qing‐Tian, additional, Dwyer, Denise, additional, Adamu, Steven, additional, Warmington, Kelly S, additional, Grisanti, Mario, additional, Tan, Hong L, additional, Ke, Hua Z, additional, Simonet, William S, additional, and Kostenuik, Paul J, additional

Published
2009
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12. Discovery of CP-533536: An EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation

Author

Cameron, Kimberly O., primary, Lefker, Bruce A., additional, Ke, Hua Z., additional, Li, Mei, additional, Zawistoski, Michael P., additional, Tjoa, Christina M., additional, Wright, Ann S., additional, DeNinno, Shari L., additional, Paralkar, Vishwas M., additional, Owen, Thomas A., additional, Yu, Li, additional, and Thompson, David D., additional

Published
2009
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13. RANKL Inhibition with Osteoprotegerin Increases Bone Strength by Improving Cortical and Trabecular bone Architecture in Ovariectomized Rats

Author

Ominsky, Michael S, primary, Li, Xiaodong, additional, Asuncion, Frank J, additional, Barrero, Mauricio, additional, Warmington, Kelly S, additional, Dwyer, Denise, additional, Stolina, Marina, additional, Geng, Zhaopo, additional, Grisanti, Mario, additional, Tan, Hong‐Lin, additional, Corbin, Timothy, additional, McCabe, James, additional, Simonet, William S, additional, Ke, Hua Z, additional, and Kostenuik, Paul J, additional

Published
2008
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16. Discovery of CP-533536: An EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation

Author

Cameron, Kimberly O., Lefker, Bruce A., Ke, Hua Z., Li, Mei, Zawistoski, Michael P., Tjoa, Christina M., Wright, Ann S., DeNinno, Shari L., Paralkar, Vishwas M., Owen, Thomas A., Yu, Li, and Thompson, David D.

Subjects
*SYNTHETIC prostaglandins E, *DRUG development, *BONE growth, *CELL receptors, *TREATMENT of fractures, *LABORATORY rats, *WOUND healing, SULFONAMIDE drugs
Abstract

Abstract: Sulfonamides, exemplified by 3a, were identified as highly selective EP2 agonists. Lead optimization led to the identification of CP-533536, 7f, a potent and selective EP2 agonist. CP-533536 demonstrated the ability to heal fractures when administered locally as a single dose in rat models of fracture healing. [Copyright &y& Elsevier]

Published
2009
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17. Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts.

Author

Korcok J, Raimundo LN, Ke HZ, Sims SM, and Dixon SJ

Subjects
Adenosine Triphosphate pharmacology, Animals, Calcium metabolism, Carrier Proteins pharmacology, Cell Differentiation drug effects, Cell Nucleus metabolism, Cells, Cultured, Cytoplasm metabolism, Membrane Glycoproteins pharmacology, Mice, Mice, Knockout, Platelet Aggregation Inhibitors pharmacology, Purinergic P2 Receptor Agonists, RANK Ligand, Rabbits, Receptor Activator of Nuclear Factor-kappa B, Receptors, Purinergic P2X4, Receptors, Purinergic P2X7, Adenosine Triphosphate analogs & derivatives, NF-kappa B metabolism, Osteoclasts metabolism, Receptors, Purinergic P2 metabolism, Signal Transduction drug effects
Abstract

Unlabelled: Nucleotides, released in response to mechanical and other stimuli, act on P2 receptors in osteoclasts and other cell types. In vitro studies of osteoclasts from rabbits and P2X7 receptor-deficient mice revealed that P2X7 receptors couple to activation of the key transcription factor NF-kappaB., Introduction: Osteoclasts express functional P2X4 and P2X7 receptors, which are ATP-gated cation channels. Knockout (KO) of the P2X7 receptor has revealed its role in regulating bone formation and resorption, but the underlying signals are not known. The transcription factor NF-kappaB plays a key role in the response of osteoclasts to RANKL and other cytokines. The aim of this study was to examine whether P2X receptors on osteoclasts signal through NF-kappaB., Materials and Methods: Osteoclasts were isolated from neonatal rabbits or wildtype (WT) and P2X7 receptor KO mice. Immunofluorescence was used to detect the p65 subunit of NF-kappaB, which, on activation, translocates from the cytosol to the nuclei. The concentration of cytosolic free Ca2+ ([Ca2+]i) was monitored in single osteoclasts loaded with fura-2., Results: In control samples, few rabbit osteoclasts demonstrated nuclear localization of NF-kappaB. Benzoyl-benzoyl-ATP (BzATP, a P2X7 agonist, 300 microM) induced nuclear translocation of NF-kappaB after 3 h in approximately 45% of rabbit osteoclasts. In contrast, a low concentration of ATP (10 microM, sufficient to activate P2X4 and P2Y2, but not P2X7 receptors) did not induce nuclear translocation of NF-kappaB. Because BzATP activates multiple P2 receptors, we examined responses of osteoclasts derived from WT and P2X7 receptor KO mice. Treatment with BzATP for 30 minutes increased nuclear localization of NF-kappaB in osteoclasts from WT but not KO mice, showing involvement of P2X7 receptors. Both ATP (10 microM) and BzATP (300 microM) caused transient elevation of [Ca2+]i, indicating that rise of calcium alone is not sufficient to activate NF-kappaB. Pretreatment of rabbit osteoclasts with osteoprotegerin inhibited translocation of NF-kappaB induced by RANKL but not by BzATP, establishing that the effects of BzATP are independent of RANKL signaling., Conclusion: These findings show that P2X7 nucleotide receptors couple to activation of NF-kappaB in osteoclasts. Thus, nucleotides, released at sites of inflammation or in response to mechanical stimuli, may act through NF-kappaB to regulate osteoclast formation and activity.

Published
2004
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