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3. The Bax inhibitor GmBI-1α interacts with a Nod factor receptor and plays a dual role in the legume-rhizobia symbiosis

Author

Yuan, Songli, primary, Ke, Danxia, additional, Liu, Bo, additional, Zhang, Mengke, additional, Li, Xiangyong, additional, Chen, Haifeng, additional, Zhang, Chanjuan, additional, Huang, Yi, additional, Sun, Shuai, additional, Shen, Jiafang, additional, Yang, Shuqi, additional, Zhou, Shunxin, additional, Leng, Piao, additional, Guan, Yuefeng, additional, and Zhou, Xinan, additional

Published
2023
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4. Durable control of metastases in an HLA-A2+ patient with refractory melanoma after low-dose radiotherapy in combination with MAGE-A4 T cell therapy: a case report

Author

He, Kewen, primary, Hong, David S., additional, Ke, Danxia, additional, Kebriaei, Partow, additional, Wang, Tianjiao, additional, Danesi, Hassan, additional, Bertolet, Genevieve, additional, Leuschner, Carola, additional, Puebla-Osorio, Nahum, additional, Voss, Tiffany A., additional, Lin, Quan, additional, Norry, Elliot, additional, Fracasso, Paula M., additional, and Welsh, James W., additional

Published
2023
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6. Supplementary Table S1 from TP53 Alterations Correlate with Response to VEGF/VEGFR Inhibitors: Implications for Targeted Therapeutics

Author

Wheler, Jennifer J., primary, Janku, Filip, primary, Naing, Aung, primary, Li, Yali, primary, Stephen, Bettzy, primary, Zinner, Ralph, primary, Subbiah, Vivek, primary, Fu, Siqing, primary, Karp, Daniel, primary, Falchook, Gerald S., primary, Tsimberidou, Apostolia M., primary, Piha-Paul, Sarina, primary, Anderson, Roosevelt, primary, Ke, Danxia, primary, Miller, Vincent, primary, Yelensky, Roman, primary, Lee, J. Jack, primary, Hong, David, primary, and Kurzrock, Razelle, primary

Published
2023
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7. Data from TP53 Alterations Correlate with Response to VEGF/VEGFR Inhibitors: Implications for Targeted Therapeutics

Author

Wheler, Jennifer J., primary, Janku, Filip, primary, Naing, Aung, primary, Li, Yali, primary, Stephen, Bettzy, primary, Zinner, Ralph, primary, Subbiah, Vivek, primary, Fu, Siqing, primary, Karp, Daniel, primary, Falchook, Gerald S., primary, Tsimberidou, Apostolia M., primary, Piha-Paul, Sarina, primary, Anderson, Roosevelt, primary, Ke, Danxia, primary, Miller, Vincent, primary, Yelensky, Roman, primary, Lee, J. Jack, primary, Hong, David, primary, and Kurzrock, Razelle, primary

Published
2023
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8. Data from Cancer Therapy Directed by Comprehensive Genomic Profiling: A Single Center Study

Author

Wheler, Jennifer J., primary, Janku, Filip, primary, Naing, Aung, primary, Li, Yali, primary, Stephen, Bettzy, primary, Zinner, Ralph, primary, Subbiah, Vivek, primary, Fu, Siqing, primary, Karp, Daniel, primary, Falchook, Gerald S., primary, Tsimberidou, Apostolia M., primary, Piha-Paul, Sarina, primary, Anderson, Roosevelt, primary, Ke, Danxia, primary, Miller, Vincent, primary, Yelensky, Roman, primary, Lee, J. Jack, primary, Hong, David S., primary, and Kurzrock, Razelle, primary

Published
2023
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9. Supplementary Table S1: from Cancer Therapy Directed by Comprehensive Genomic Profiling: A Single Center Study

Author

Wheler, Jennifer J., primary, Janku, Filip, primary, Naing, Aung, primary, Li, Yali, primary, Stephen, Bettzy, primary, Zinner, Ralph, primary, Subbiah, Vivek, primary, Fu, Siqing, primary, Karp, Daniel, primary, Falchook, Gerald S., primary, Tsimberidou, Apostolia M., primary, Piha-Paul, Sarina, primary, Anderson, Roosevelt, primary, Ke, Danxia, primary, Miller, Vincent, primary, Yelensky, Roman, primary, Lee, J. Jack, primary, Hong, David S., primary, and Kurzrock, Razelle, primary

Published
2023
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14. 376 Radiation sub-study to characterize safety and tolerability of low-dose radiation in combination with afami-cel in patients with advanced cancers (NCT03132922)

Author

Welsh, James, primary, Ke, Danxia, additional, Osorio, Nahum Puebla, additional, Barsoumian, Hampartsoum, additional, Jackson, Bryan, additional, Bai, Jane, additional, Rosenberg, Marisa, additional, McAlpine, Cheryl, additional, Broad, Robyn, additional, Liddle, Ashley, additional, Navenot, Jean-Marc, additional, Rafail, Stavros, additional, Wang, Ruoxi, additional, Sauer, Amy, additional, Lin, Quan, additional, Danesi, Hassan, additional, and Hong, David, additional

Published
2021
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17. Genome-Wide Identification and Classification of Soybean C2H2 Zinc Finger Proteins and Their Expression Analysis in Legume-Rhizobium Symbiosis

Author

Yuan, Songli, primary, Li, Xiangyong, additional, Li, Rong, additional, Wang, Lei, additional, Zhang, Chanjuan, additional, Chen, Limiao, additional, Hao, Qingnan, additional, Zhang, Xiaojuan, additional, Chen, Haifeng, additional, Shan, Zhihui, additional, Yang, Zhonglu, additional, Chen, Shuilian, additional, Qiu, Dezhen, additional, Ke, Danxia, additional, and Zhou, Xinan, additional

Published
2018
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21. TP53 Alterations Correlate with Response to VEGF/VEGFR Inhibitors: Implications for Targeted Therapeutics

Author

Wheler, Jennifer J., primary, Janku, Filip, additional, Naing, Aung, additional, Li, Yali, additional, Stephen, Bettzy, additional, Zinner, Ralph, additional, Subbiah, Vivek, additional, Fu, Siqing, additional, Karp, Daniel, additional, Falchook, Gerald S., additional, Tsimberidou, Apostolia M., additional, Piha-Paul, Sarina, additional, Anderson, Roosevelt, additional, Ke, Danxia, additional, Miller, Vincent, additional, Yelensky, Roman, additional, Lee, J. Jack, additional, Hong, David, additional, and Kurzrock, Razelle, additional

Published
2016
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22. Cancer Therapy Directed by Comprehensive Genomic Profiling: A Single Center Study

Author

Wheler, Jennifer J., primary, Janku, Filip, additional, Naing, Aung, additional, Li, Yali, additional, Stephen, Bettzy, additional, Zinner, Ralph, additional, Subbiah, Vivek, additional, Fu, Siqing, additional, Karp, Daniel, additional, Falchook, Gerald S., additional, Tsimberidou, Apostolia M., additional, Piha-Paul, Sarina, additional, Anderson, Roosevelt, additional, Ke, Danxia, additional, Miller, Vincent, additional, Yelensky, Roman, additional, Lee, J. Jack, additional, Hong, David S., additional, and Kurzrock, Razelle, additional

Published
2016
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30. Heat Treatment of Small Heat Shock Proteins α-Crystallin and Hsp16.3: Structural Changes vs. Chaperone-like Activity

Author

MAO Qilong, KE Danxia, CHANG Zengyi and MAO Qilong, KE Danxia, CHANG Zengyi

Abstract

Both α-crystallin from bovine eye lens and Hsp16.3 from Mycobacterium tuberculosis are members of the small heat shock protein family. They were preincubated at 100°C for 15 min and then cooled on ice immediately. The chaperone-like activities of preheated proteins were measured at 37° using DTT-treated insulin B chains as substrates. Both preheated proteins exhibited greatly enhanced chaperone-like activities, accompanied with almost unchanged secondary structures and surface hydrophobicity but with a minor change in tertiary structures. The dramatically enhanced chaperone-like activities of preheated a-crystallin and Hsp16.3 may have resulted from the irreversible change in the tertiary structure as detected by near-UV CD spectra.

Published
2003

33. A MYB coiled-coil transcription factor interacts with NSP2 and is involved in nodulation in Lotus japonicus.

Author

Kang, Heng, Chu, Xiaojie, Wang, Chao, Xiao, Aifang, Zhu, Hui, Yuan, Songli, Yang, Zhenzhen, Ke, Danxia, Xiao, Shaobo, Hong, Zonglie, and Zhang, Zhongming

Subjects
MYB gene, GENETIC transcription in plants, LOTUS japonicus, TRANSCRIPTION factors, GENE expression in plants
Abstract

Transcription factor complex formation is a central step in regulating gene expression. In this report, a novel MYB coiled-coil transcription factor referred to as IPN2, for Interacting Protein of NSP2, is described., The interaction between IPN2 and NSP2 was examined by protein pull-down assays and bimolecular fluorescence complementation ( Bi FC). Subcellular localization of proteins, gene expression and gene function were assessed in transgenic hairy roots expressing tagged recombinant proteins, promoter-reporter and RNA interference ( RNAi) constructs, respectively., The GRAS domain of NSP2 and the coiled-coil domain of IPN2 were found to be responsible for the interaction between the two proteins. IPN2 had strong transcription activation activity, bound directly to the NIN gene promoter, and was localized to the nuclei of Lotus japonicus root cells. The expression of IPN2 was elevated during nodule development, coinciding with increased NSP2 gene expression during nodule organogenesis. RNAi-mediated knockdown expression of IPN2 did not affect arbuscular mycorrhizal development, but had deleterious effects on rhizobial infection and nodule formation in L. japonicus., These results demonstrate an important role of IPN2 in nodule organogenesis and place a new MYB transcription factor in the Nod signaling pathway. [ABSTRACT FROM AUTHOR]

Published
2014
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34. MAP Kinase Kinase Interacts with SymRK and Regulates Nodule Organogenesis in Lotus japonicus.

Author

Chen, Tao, Zhu, Hui, Ke, Danxia, Cai, Kai, Wang, Chao, Gou, Honglan, Hong, Zonglie, and Zhang, Zhongming

Subjects
LOTUS japonicus, RNA interference, GENE expression, RECOMBINANT proteins, MORPHOGENESIS
Abstract

The symbiosis receptor kinase, SymRK, is required for root nodule development. A SymRK-interacting protein (SIP2) was found to form protein complex with SymRK in vitro and in planta. The interaction between SymRK and SIP2 is conserved in legumes. The SIP2 gene was expressed in all Lotus japonicus tissues examined. SIP2 represents a typical plant mitogen-activated protein kinase kinase (MAPKK) and exhibited autophosphorylation and transphosphorylation activities. Recombinant SIP2 protein could phosphorylate casein and the Arabidopsis thaliana MAP kinase MPK6. SymRK and SIP2 could not use one another as a substrate for phosphorylation. Instead, SymRK acted as an inhibitor of SIP2 kinase when MPK6 was used as a substrate, suggesting that SymRK may serve as a negative regulator of the SIP2 signaling pathway. Knockdown expression of SIP2 via RNA interference (RNAi) resulted in drastic reduction of nodules formed in transgenic hairy roots. A significant portion of SIP2 RNAi hairy roots failed to form a nodule. In these roots, the expression levels of SIP2 and three marker genes for infection thread and nodule primordium formation were downregulated drastically, while the expression of two other MAPKK genes were not altered. These observations demonstrate an essential role of SIP2 in the early symbiosis signaling and nodule organogenesis. [ABSTRACT FROM AUTHOR]

Published
2012
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35. Rhesus TRIM5a Disrupts the HIV-1 Capsid at the Inter-Hexamer Interfaces.

Author

Gongpu Zhao, Ke, Danxia, Vu, Thomas, Jinwoo Ahn, Shah, Vaibhav B., Yang, Ruifeng, Aiken, Christopher, Charlton, Lisa M., Gronenborn, Angela M., and Peijun Zhang

Subjects
*PROTEINS, *NATURAL immunity, *RETROVIRUS diseases, *HIV infections, *RHESUS monkeys, *VIRION, *IMMUNE response, *PREVENTION
Published
2011

36. Exposure to a Cutinase-like Serine Esterase Triggers Rapid Lysis of Multiple Mycobacterial Species.

Author

Yong Yang, Bhatti, Alexandra, Ke, Danxia, Gonzalez-Juarrero, Mercedes, Lenaerts, Anne, Kremer, Laurent, Guerardel, Yann, Zhang, Peijun, and Ojha, Anil K.

Subjects
*ACTINOMYCETALES, *MYCOBACTERIAL diseases, *ARCHITECTURAL design, *ORGANIC compounds, *TUBERCULIN
Abstract

Mycobacteria are shaped by a thick envelope made of an array of uniquely structured lipids and polysaccharides. However, the spatial organization of these molecules remains unclear. Here, we show that exposure to an esterase from Mycobacterium smegmatis (Msmeg_1529), hydrolyzing the ester linkage of trehalose dimycolate in vitro, triggers rapid and efficient lysis of Mycobacterium tuberculosis, Mycobacterium bovis BCG, and Mycobacterium marinum. Exposure to the esterase immediately releases free mycolic acids, while concomitantly depleting trehalose mycolates. Moreover, lysis could be competitively inhibited by an excess of purified trehalose dimycolate and was abolished by a S124A mutation affecting the catalytic activity of the esterase. These findings are consistent with an indispensable structural role of trehalose mycolates in the architectural design of the exposed surface of the mycobacterial envelope. Importantly, we also demonstrate that the esterase-mediated rapid lysis of M. tuberculosis significantly improves its detection in paucibacillary samples. [ABSTRACT FROM AUTHOR]

Published
2013
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