Author: "Kazuya Murata" - Searchworks@Jio Institute Digital Library Search Results

377 results on '"Kazuya Murata"'

1. The 'vegetables first' dietary habit correlates with higher-level functional capacity in older adults with diabetes

Author: Satoshi Ida, Kanako Imataka, Shoki Morii, and Kazuya Murata
Subjects: Older adults with diabetes, Nutrition, Activities of daily living, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456, Medicine (General), R5-920
Abstract: Abstract Background Some studies suggest that the habit of eating vegetables may initially be correlated with maintenance of a higher-level functional capacity; however, such a correlation has not been demonstrated. This study aimed to correlate the habit of eating vegetables first and higher-level functional capacity in older adults with diabetes. Methods Patients aged ≥ 60 years who were treated at Japanese Red Cross Ise Hospital on an ambulatory basis were included in this study. A self-administered questionnaire using the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC) was used to evaluate higher-level functional capacity. Participants were instructed to answer the questionnaire regarding the order in which they consumed the mentioned food types, and based on their answers, they were classified into “no order of eating,” “carbohydrates first,” “protein first,” and “vegetables first” groups. Multiple regression analyses with the TMIG-IC score as a dependent variable and the order of eating as explanatory variables were used to determine the partial regression coefficients of the “vegetables first” dietary habit with higher-level functional capacity. Results This study included 346 patients. The adjusted partial regression coefficients of the “carbohydrates first,” “protein first,” and “vegetables first” dietary habits with the TMIG-IC score were 0.27 (95% confidence interval [CI], − 0.29 to 0.84), 0.17 (95% CI, − 0.54 to 0.90), and 0.77 (95% CI, 0.23 to 1.31), respectively. Conclusions The habit of eating vegetables first was correlated with higher-level functional capacity in older adults with diabetes.
Published: 2024
Full Text: View/download PDF

2. Regional random mutagenesis driven by multiple sgRNAs and diverse on-target genome editing events to identify functionally important elements in non-coding regions

Author: Kento Morimoto, Hayate Suzuki, Akihiro Kuno, Yoko Daitoku, Yoko Tanimoto, Kanako Kato, Kazuya Murata, Fumihiro Sugiyama, and Seiya Mizuno
Subjects: region-specific random mutagenesis, CRISPR-Cas9, PiggyBac, non-coding region, microRNA cluster, Biology (General), QH301-705.5
Abstract: Functional regions that regulate biological phenomena are interspersed throughout eukaryotic genomes. The most definitive approach for identifying such regions is to confirm the phenotype of cells or organisms in which specific regions have been mutated or removed from the genome. This approach is invaluable for the functional analysis of genes with a defined functional element, the protein-coding sequence. By contrast, no functional analysis platforms have been established for the study of cis-elements or microRNA cluster regions consisting of multiple microRNAs with functional overlap. Whole-genome mutagenesis approaches, such as via N-ethyl-N-nitrosourea and gene trapping, have greatly contributed to elucidating the function of coding genes. These methods almost never induce deletions of genomic regions or multiple mutations within a narrow region. In other words, cis-elements and microRNA clusters cannot be effectively targeted in such a manner. Herein, we established a novel region-specific random mutagenesis method named CRISPR- and transposase-based regional mutagenesis (CTRL-mutagenesis). We demonstrate that CTRL-mutagenesis randomly induces diverse mutations within target regions in murine embryonic stem cells. Comparative analysis of mutants harbouring subtly different mutations within the same region would facilitate the further study of cis-element and microRNA clusters.
Published: 2024
Full Text: View/download PDF

3. Development of the 'Social Participation Barriers in Patients With Diabetes' Questionnaire for Older Patients With Diabetes and Evaluation of its Reliability and Validity

Author: Satoshi Ida MD, Kanako Imataka MD, Shoki Morii MD, and Kazuya Murata MD
Subjects: Geriatrics, RC952-954.6
Abstract: Objectives: To develop a questionnaire for evaluating the factors hindering social participation in older patients with diabetes (the Social Participation Barriers in Patients with Diabetes [SPBD] questionnaire) and assess its reliability and validity. Materials and Methods: This is a cross-sectional study. This study included outpatients aged ≥60 years having diabetes and undergoing treatment at the Ise Redcross Hospital. A draft questionnaire consisting of 20 questions was developed with reference to previous studies. Logistic regression analysis was conducted, and Cronbach’s alpha coefficient was calculated. Exploratory factor analysis was conducted to test construct validity. Pearson’s correlation coefficients between SPBD scores and frailty scores, social frailty scores and frequency of outings were calculated. Results: Overall, 353 patients were included in the analysis. After questions without an association in the logistic regression analysis were excluded and results of the exploratory factor analyses were obtained, 10 questions were excluded. As a result, we created a 10-item SPBD questionnaire. Cronbach’s alpha coefficient was .87. The SPBD score was significantly associated with frequency of going out, and frailty. Conclusions: We created an SPBD questionnaire to assess barriers to social participation in older adult patients with diabetes. This study indicated the validity and reliability of the questionnaire.
Published: 2024
Full Text: View/download PDF

4. Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function

Author: Motohiro Sekiya, Yang Ma, Kenta Kainoh, Kenji Saito, Daichi Yamazaki, Tomomi Tsuyuzaki, Wanpei Chen, Putu Indah Paramita Adi Putri, Hiroshi Ohno, Takafumi Miyamoto, Yoshinori Takeuchi, Yuki Murayama, Yoko Sugano, Yoshinori Osaki, Hitoshi Iwasaki, Naoya Yahagi, Hiroaki Suzuki, Kaori Motomura, Takashi Matsuzaka, Kazuya Murata, Seiya Mizuno, Satoru Takahashi, and Hitoshi Shimano
Subjects: CP: Metabolism, CP: Molecular biology, Biology (General), QH301-705.5
Abstract: Summary: The adaptive increase in insulin secretion in early stages of obesity serves as a safeguard mechanism to maintain glucose homeostasis that cannot be sustained, and the eventual decompensation of β cells is a key event in the pathogenesis of diabetes. Here we describe a crucial system orchestrated by a transcriptional cofactor CtBP2. In cultured β cells, insulin gene expression is coactivated by CtBP2. Global genomic mapping of CtBP2 binding sites identifies a key interaction between CtBP2 and NEUROD1 through which CtBP2 decompacts chromatin in the insulin gene promoter. CtBP2 expression is diminished in pancreatic islets in multiple mouse models of obesity, as well as human obesity. Pancreatic β cell-specific CtBP2-deficient mice manifest glucose intolerance with impaired insulin secretion. Our transcriptome analysis highlights an essential role of CtBP2 in the maintenance of β cell integrity. This system provides clues to the molecular basis in obesity and may be targetable to develop therapeutic approaches.
Published: 2023
Full Text: View/download PDF

5. Regulation of neural stem cell proliferation and survival by protein arginine methyltransferase 1

Author: Misuzu Hashimoto, Kaho Takeichi, Kazuya Murata, Aoi Kozakai, Atsushi Yagi, Kohei Ishikawa, Chiharu Suzuki-Nakagawa, Yoshitoshi Kasuya, Akiyoshi Fukamizu, and Tsutomu Nakagawa
Subjects: PRMT1, neural stem cell, apoptosis, development, p53, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Protein arginine methyltransferase 1 (PRMT1), a major type I arginine methyltransferase in mammals, methylates histone and non-histone proteins to regulate various cellular functions, such as transcription, DNA damage response, and signal transduction. PRMT1 is highly expressed in neural stem cells (NSCs) and embryonic brains, suggesting that PRMT1 is essential for early brain development. Although our previous reports have shown that PRMT1 positively regulates oligodendrocyte development, it has not been studied whether PRMT1 regulates NSC proliferation and its survival during development. To examine the role of PRMT1 in NSC activity, we cultured NSCs prepared from embryonic mouse forebrains deficient in PRMT1 specific for NSCs and performed neurosphere assays. We found that the primary neurospheres of PRMT1-deficient NSCs were small and the number of spheres was decreased, compared to those of control NSCs. Primary neurospheres deficient in PRMT1 expressed an increased level of cleaved caspase-3, suggesting that PRMT1 deficiency-induced apoptosis. Furthermore, p53 protein was significantly accumulated in PRMT1-deficient NSCs. In parallel, p53-responsive pro-apoptotic genes including Pmaip1 and Perp were upregulated in PRMT1-deficient NSCs. p53-target p21 mRNA and its protein levels were shown to be upregulated in PRMT1-deficient NSCs. Moreover, the 5-bromo-2′-deoxyuridine (BrdU) incorporation assay showed that the loss of PRMT1 led to cell cycle defects in the embryonic NSCs. In contrast to the above in vitro observations, NSCs normally proliferated and survived in the fetal brains of NSC-specific PRMT1-deficient mice. We also found that Lama1, which encodes the laminin subunit α1, was significantly upregulated in the embryonic brains of PRMT1-deficient mice. These data implicate that extracellular factors provided by neighboring cells in the microenvironment gave a trophic support to NSCs in the PRMT1-deficient brain and recovered NSC activity to maintain brain homeostasis. Our study implies that PRMT1 plays a cell-autonomous role in the survival and proliferation of embryonic NSCs.
Published: 2022
Full Text: View/download PDF

6. Association of body mass index with outcomes in patients with newly diagnosed atrial fibrillation: GARFIELD-AF

Author: Daniela Poli, Sophie Testa, Corrado Lodigiani, Toon Wei Lim, Kevin Jones, Kangning Chen, Hui Li, Hilary Pinnock, Grzegorz Bilo, Hack-Lyoung Kim, Andrew Murray, Bernard J Gersh, Kurt Huber, Robin Fox, Sarah Davies, James Rogers, Morten Schou, Xin Li, Vira Tseluyko, Sergey Popov, Rajeev Gupta, Grzegorz Opolski, Preeti Pandya, Bronte Ayres, Milan Gupta, Peter Hutchinson, Phil Simmons, Andrew Gallagher, Michel Galinier, Franck Paganelli, Jens Kilian, Adam Blenkhorn, Mohamed Ibrahim, Fernando Lanas, Karen Pieper, Eivind Berge, M Clark, Agneta Andersson, Karim Ladha, Bijoy Sinha, Torstein Hole, Dan Atar, Hywel Jones, R Smith, Andrew Ross, Emmanuel Ellie, Paul Evans, Yong Wang, Hiroshi Ono, Tadashi Nakamura, Paul MacDonald, Stephen Rogers, Igor Sibon, Simon Dobson, David Fitzmaurice, Jiyan Chen, Neil Roberts, Pierre Amarenco, Nigel Hart, Giancarlo Agnelli, Georges Mairesse, Pekka Raatikainen, Oleg Sychov, Yasuyuki Suzuki, Bo Liu, Mathieu Zuber, John French, Yuejin Yang, Myeong-Chan Cho, Julian Thompson, Michael Stokes, John W Eikelboom, Mark Richardson, John Matthews, Will Murdoch, Jean-Philippe Neau, Freek Verheugt, Ajay K Kakkar, Giuseppe Ambrosio, Marcin Gruchała, Keith A A Fox, Sunil Kumar, Ruiping Zhao, Patrick Carroll, Masanori Kaneko, Thanh Phan, Ping Yang, Sung-Won Jang, Claire Jones, Mårten Rosenqvist, Johan Engdahl, Debabrata Roy, John Cairns, Ping Chen, Michael Olsen, Paul Angaran, David Russell, Helena Dominguez, Béla Merkely, Joseph Berlingieri, James Bennett, Hugo ten Cate, Hiroshi Yamaguchi, Masahiro Minamoto, Hiroyuki Oda, Toshihiko Shiraiwa, Jonathan Webster, Yukihiro Koretsune, Kotaro Obunai, R Thompson, Yong Seog Oh, Giuliana Guazzaloca, Giuliana Martini, Marc Bonnefoy, Michael Cox, András Nagy, Kazuki Sato, Richard Davies, Daisuke Ikeda, Susumu Suzuki, Hiroki Teragawa, Koji Matsushita, Ying Guo, Catherine Neden, Mark Pugsley, Simon Cartwright, Polly Jacobs, Xiaoshu Cheng, Daniel Nishijima, Sylvia Haas, Vinay Kumar, Saverio Virdone, Jean-Pierre Bassand, Samuel Z Goldhaber, Shinya Goto, Frank Misselwitz, Alexander G G Turpie, Alison Macleod, Karen Forshaw, Mark Boon, Stephen Miller, Simon Wetherell, Moustafa Moustafa, Gaetano Serviddio, Renato Lopes, Kazuo Takei, Hiroaki Nishioka, Mykola Stanislavchuk, C Ramesh, R Kamath, Stuart J Connolly, Nooshin Bazargani, Kevin Douglas, Werner Hacke, Gloria Kayani, Ali Oto, Hiroshi Watanabe, Walter Hermans, Kazuya Murata, Christian Fielder Camm, Marco Moia, Niraj Sharma, Jaeyoung Kim, Walter Abhayaratna, Andriy Yagensky, Hosen Kiat, Wilhelm Haverkamp, Yang Jiao, Hitoshi Kato, Jindrich Spinar, Daniel Theodoro, Philip Cooke, Paolo Golino, Tetsuro Yoshida, Prakash Chandwani, Christine A'Court, Brian Ramjattan, Torbjørn Øien, Toshiyuki Kobayashi, Richard West, Petr Jansky, Seil Oh, Jan Steffel, Martin van Eickels, Hyung-Wook Park, Nam-Ho Kim, Søren Rasmussen, Kazuo Suzuki, David Colquhoun, Hiroshi Ando, Simon Franklin, Tae-Joon Cha, Sang Cheol Bae, Guosheng Fu, Yoshihiro Saito, Heinz Drexel, Michel Martelet, Joseph Mouallem, Nicolas Delarche, Sylvain Destrac, Neil Macey, Andreas Kopf, Masayuki Nakano, Olga Barbarash, Takeshi Inoue, Taro Minagawa, Weihua Li, John Eikelboom, Hiroshi Kubo, Lars Andersson, D Burns, Andrea Podczeck-Schweighofer, Megumi Okada, Massimo Volpe, Takuma Aoyama, Karsten Mueller, Carlos Astudillo, Hiroshi Takeda, Peter Mayer, Jung Hoon Sung, Dinesh Jain, Jung Han Yoon, Alessandro Capucci, Dongryeol Ryu, Kelvin Wong, Hong Euy Lim, Xiaowei Yan, Yusheng Zhao, Yuehui Yin, YUKIHIRO SETA, Taek Jong Hong, MASAKI SHIMOYAMA, Dayi Hu, Junichi Minami, Yuriy Mostovoy, David Foo, Ramazan Topsakal, Zhi-Cheng Jing, Dipen Shah, Kenichi Yamamoto, David Coulshed, Olivier Piot, Ramón Corbalán, Silva Severi, Waldemar Myszka, Mehmet Birhan Yilmaz, Gi-Byoung Nam, Jun Kim, Harald Darius, Jan-Erik Karlsson, PETER VANDERGOTEN, Nasser Taha, Shuta Toru, Jörn Nielsen, Tsutomu Takagi, Koji Higuchi, Steen Husted, Tomohiro Katsuya, Frank Cools, Iveta Petrova, Songkwan Silaruks, GÜNTER LEHMANN, Frederic Casassus, Bernard Crousillat, Bernard Doucet, Jean-Joseph Muller, Grzegorz Raczak, Kazuyuki Saito, Anders Ostrem, Chi Keong Ching, KUNIHIKO YAMAMOTO, John Camm, Carmine Mazzone, Jaemin Shim, Jadwiga Nessler, Jan Vercammen, Marc Delforge, Chong-Jin Kim, Pierre Nazeyrollas, Louise Lumley, Paul Roome, Helen Stoddart, Mark Rickenbach, Paul Mullen, Noriyuki Nakanishi, Gordon Irvine, Paul Conn, Kurt Lenz, Richard Coates, E Fisher, Warwick Coulson, Jiri Lastuvka, Pablo García Pavía, P Jhittay, Philip Saunders, Peter Bernhardt, Wanwarang Wongcharoen, Kentaro Yamamoto, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Jørn Dalsgaard Nielsen, Hany Ragy, Matyas Keltai, Jitendra Pal Singh Sawhney, Janina Stepinska, Elizaveta Panchenko, Barry Jacobson, Xavier Viñolas, Pantep Angchaisuksiri, Alex Parkhomenko, Huaiqin Zhang, Shiping Cao, Daowen Wang, Guizhou Tao, Yingmin Chen, Shenghu He, Tongguo Wu, Moshui Chen, Longgen Xiong, Praveen Jadhavm, Raghava Sarma, Govind Kulkarni, Rasesh Atulbhai Pothiwala, Mohanan Padinhare Purayil, Kamaldeep Chawla, Veerappa Annasaheb Kothiwale, Bagirath Raghuraman, Vinod Madan Vijan, Jitendra Sawhney, Ganapathi Bantwal, Aziz Khan, Ramdhan Meena, Manojkumar Chopada, Sunitha Abraham, Vikas Bisne, Govindan Vijayaraghavan, Rajashekhar Durgaprasad, Kartikeya Bhargava, Udigala Madappa Nagamalesh, Rajeeve Kumar Rajput, Seishu Kanamori, Koichiro Kumagai, Yosuke Katsuda, Keiki Yoshida, Fumitoshi Toyota, Yuji Mizuno, Ikuo Misumi, Hiroo Noguchi, Shinichi Ando, Tetsuro Suetsugu, Susumu Adachi, Kei Chiba, Hiroaki Norita, Makoto Tsuruta, Takeshi Koyanagi, Takayuki Higashi, Shiro Azakami, Shinichiro Komaki, Kenshi Kumeda, Takashi Murayama, Jun Matsumura, Yurika Oba, Ryuji Sonoda, Kazuo Goto, Kotaro Minoda, Yoshikuni Haraguchi, Hisakazu Suefuji, Hiroo Miyagi, Tsugihiro Nakamura, Hidekazu Nandate, Ryuji Zaitsu, Yoshihisa Fujiura, Akira Yoshimura, Hiroyuki Numata, Jun Ogawa, Yasuyuki Kamogawa, Kinshiro Murakami, Yutaka Wakasa, Masanori Yamasawa, Hiromitsu Maekawa, Sumihisa Abe, Hajime Kihara, Satoru Tsunoda, Katsumi Saito, Hiroki Tachibana, Ichiro Oba, Takashi Kuwahata, Satoshi Higa, Masamichi Gushiken, Takuma Eto, Hidetoshi Chibana, Kazuaki Fujisawa, Yuhei Shiga, Hirokuni Sumi, Toshihisa Nagatomo, Yoshihiko Atsuchi, Toshiro Nagoshi, Kazuhisa Sanno, Fumihiro Hoshino, Naoto Yokota, Masahiro Kameko, Toshifumi Tabuchi, Munesumi Ishizawa, Yoshitake Fujiura, Taku Seto, Tetsu Iwao, Norio Ishioka, Koichi Oshiro, Keizo Tsuchida, Yutaka Hatori, Motoshi Takeuchi, Hiroto Takezawa, Shinjiro Nagano, Masaaki Iwaki, Yuichiro Nakamura, Naomasa Miyamoto, Toshifumi Taguchi, Ko Ashida, Naoto Yoshizawa, Jun Agata, Seishiro Matsukawa, Osamu Arasaki, Shuji Fukuoka, Hirofumi Murakami, Kazuya Mishima, Yoshiki Hata, Ichiro Sakuma, Ichiro Takamura, Mitsuyuki Akutsu, Toshihide Unoki, Yoshinori Go, Makoto Ikemura, Shoji Morii, Shigeru Marusaki, Hideo Doi, Mitsuru Tanaka, Takaaki Kusumoto, Shigeo Kakinoki, Chiga Ogurusu, Masami Nakatsuka, Yutaka Kitami, Yoichi Nakamura, Hiroshi Oda, Rikimaru Oyama, Masato Ageta, Teruaki Mita, Kazuhiko Nagao, Takafumi Mito, Mitsunori Abe, Masako Fujii, Makoto Okawa, Tsuneo Fujito, Toshiya Taniguchi, Tenei Ko, Mizuho Imamaki, Masahiro Akiyama, Takashi Ueda, Hironori Odakura, Masahiko Inagaki, Yoshiki Katsube, Atsuyuki Nakata, Shinobu Tomimoto, Mitsuhiro Shibuya, Kenichiro Ito, Masahiro Matsuta, Motoyuki Ishiguro, Masamichi Wada, Hiroaki Mukawa, Masato Mizuguchi, Fumio Okuda, Teruaki Kimura, Kuniaki Taga, Masaaki Techigawara, Morio Igarashi, Toshihiko Seo, Shinya Hiramitsu, Hiroaki Hosokawa, Mitsumoto Hoshiai, Michitaka Hibino, Koichi Miyagawa, Hideki Horie, Nobuyoshi Sugishita, Yukio Shiga, Akira Soma, Kazuo Neya, Kunio Akahane, Saori Matsui, Hirofumi Kanda, Shiro Nagasaka, Atsushi Taguchi, Akiko Miyashita, Hiroki Sasaguri, Jin Nariyama, Taketo Hatsuno, Takash Iwase, Kazuya Kawai, Tomobumi Kotani, Tsuyoshi Tsuji, Hirosumi Sakai, Kiyoshi Nishino, Kenichi Ikeda, Kazuo Maeda, Tomohiro Shinozuka, Koichi Kawakami, Hiromichi Kitazumi, Mamoru Hamaoka, Jisho Kojima, Akitoshi Sasaki, Yoshihiro Tsuchiya, Tetsuo Betsuyaku, Masaaki Honda, Koichi Hasegawa, Takao Baba, Kazuaki Mineoi, Toshihiko Koeda, Kunihiko Hirasawa, Toshihide Kumazaki, Akira Nakagomi, Eiji Otaki, Takashi Shindo, Hiroyoshi Hirayama, Chikako Sugimoto, Takashi Yamagishi, Ichiro Mizuguchi, Kazunori Sezaki, Isamu Niwa, Ken Takenaka, Osamu Iiji, Koichi Taya, Hitoshi Kitazawa, Samu Ueda, Hirokazu Kakuda, Takuya Ono, Seizo Oriso, Junya Kamata, Toshihiko Nanke, Itaru Maeda, Yoshifusa Matsuura, Yasuyuki Maruyama, Hajime Horie, Tetsutaro Kito, Hiroshi Asano, Masaichi Nakamura, Takashi Washizuka, Tomoki Yoshida, Masato Sawano, Shinichi Arima, Hidekazu Arai, Hisanori Shinohara, Hiroyuki Takai, Nobufusa Furukawa, Akira Ota, Kenji Aoki, Taku Yamamoto, Takeaki Kasai, Shunji Suzuki, Shu Suzuki, Nitaro Shibata, Masayuki Watanabe, Yosuke Nishihata, Toru Arino, Masaki Okuyama, Tetsushi Wakiyama, Tomoko Kato, Yasuo Sasagawa, Takeshi Tana, Yoshihito Hayashi, Shinichi Hirota, Yukihiko Abe, Hirohide Uchiyama, Shuichi Tohyo, Naoto Hanazono, Seiichi Miyajima, Hisashi Shimono, Yasunobu Shozawa, Yawara Niijima, Osamu Murai, Hideko Inaba, Katsumasa Nomura, Masatsugu Nozoe, Toshiyuki Furukawa, Nobuhisa Ito, Shunichi Nagai, Kiyoharu Sato, Shiro Nakahara, Yujin Shimoyama, Naoko Ohara, Teruhiko Kozuka, Hideaki Okita, Masato Endo, Tsutomu Goto, Makoto Hirose, Emiko Nagata, Toshizumi Mori, Shuichi Seki, Katsuhiro Okamoto, Osamu Moriai, Yoko Emura, Tsuyoshi Fukuda, Haruhiko Date, Shuichi Kawakami, Sho Nagai, Yuya Ueyama, Tetsuro Fudo, Mitsuru Imaizumi, Takuo Ogawa, Shunsuke Take, Hideo Ikeda, Norihiko Sakamoto, Kiyomitsu Ikeoka, Nobuo Wakaki, Masatake Abe, Junji Doiuchi, Tetsuya Kira, Masato Tada, Ken Tsuzaki, Naoya Miura, Yasuaki Fujisawa, Wataru Furumoto, Akinori Fujisawa, Ryosai Nakamura, Hiroyasu Komatsu, Rei Fujiki, Shuichi Kawano, Keijiro Nishizawa, Yoji Kato, Junya Azuma, Kiyoshi Yasui, Toshio Amano, Yasuhiro Sekine, Tatsuo Honzawa, Yuichiro Koshibu, Yasuhide Sakamoto, Shingo Miyaguchi, Kojuro Morishita, Yasuko Samejima, Toyoshi Sasaki, Fumiko Iseki, Hiroshi Kano, Yoichi Takagi, Yoko Onuki Pearce, Takayuki Fukui, Toru Nakayama, Hideaki Kanai, Yoshiyuki Kawano, Tetsuji Ino, Hironori Miyoshi, Yasufumi Miyamoto, Masahito Shigekiyo, Shimato Ono, Yutaka Okamoto, Satoshi Ubukata, Kojiro Kodera, Tatsuo Oriuchi, Naoki Matsumoto, Koichi Inagaki, Atsushi Iseki, Tomohiro Yoshida, Toshihiro Goda, Tsukasa Katsuki, Atsushi Sato, Etsuo Mori, Toshio Tsubokura, Hiroshi Shudo, Shunichi Fujimoto, Yoshiyuki Furukawa, Hiroshi Hosokawa, Jun Narumi, Kiichiro Yamamoto, Masaki Owari, Takuya Inakura, Takafumi Anno, Kazuyuki Shirakawa, Tan Yuyang, Hui Nam Park, Woo-Shik Kim, HyeYoung Lee, Dae Hyeok Kim, Dae-Kyeong Kim, Dong Ju Choi, Hui-Kyung Jeon, Dong-Gu Shin, Sang Weon Park, Hoon Ki Park, Sang-Jin Han, Young Keun On, JaeJin Kwak, Seong Hoon Park, Kee-Sik Kim, Byung Chun Jung, Gyo-Seung Hwang, Sakda Rungaramsin, Peerapat Katekangplu, Porames Khunrong, Thanita Bunyapipat, Pinij Kaewsuwanna, Khanchai Siriwattana, Waraporn Tiyanon, Supalerk Pattanaprichakul, Khanchit Likittanasombat, Doungrat Cholsaringkarl, Warangkana Boonyapisit, Sirichai Cheewatanakornkul, Pisit Hutayanon, Seksan Chawanadelert, Pairoj Chattranukulchai, Boonsert Chatlaong, Yingsak Santanakorn, Khompiya Kanokphatcharakun, Piya Mongkolwongroj, Sasivimon Jai-Aue, Ongkarn Komson, Armagan Altun, Ali Aydinlar, Zeki Ongen, Sadik Acikel, Durmus Yildiray Sahin, Ozcan Yilmaz, Hasan Pekdemir, Mesut Demir, Murat Sucu, Levent Sahiner, Murat Ersanli, Ertugrul Okuyan, Dursun Aras, Florencia Rolandi, Adrian Cesar Ingaramo, Gustavo Alberto Sambadaro, Vanina Fernandez Caputi, Hector Luciardi, Sofia Graciela Berman, Pablo Dragotto, Andres Javier Kleiban, Nestor Centurion, Ricardo Dario Dran, Javier Egido, Matias Jose Fosco, Victor Alfredo Sinisi, Luis Rodolfo Cartasegna, Oscar Gomez Vilamajo, Jose Luis Ramos, Sonia Sassone, Gerardo Zapata, Diego Conde, Guillermo Giacomi, Alberto Alfredo Fernandez, Mario Alberto Berli, Fabian Ferroni, Jefferson Jaber, Luciana Vidal Armaganijan, André Steffens, José Márcio Ribeiro, Marcelo Silveira Teixeira, Paulo Rossi, Leonardo Pires, Daniel Moreira, Luiz Bodanese, Marcelo Westerlund Montera, Jamil Abdalla Saad, Euler Roberto Manenti, Alexandre Negri, Carlos Moncada, Dalton Precoma, Fernando Roquette, Gilmar Reis, Estêvão Lanna Figueiredo, Roberto Vieira Botelho, Helius Carlos Finimundi, Adriano Kochi, Fábio Alban, Rogério Tadeu Tumelero, Lilia Maia, Humberto Montecinos, Martín Larico Gómez, Carlos Conejeros, Patricio Marin Cuevas, Alejandro Forero, Claudio Bugueño Gutiérrez, Juan Aguilar, Sergio Potthoff Cardenas, German Eggers, Cesar Houzvic, Carlos Rey, Germán Arriagada, Gustavo Charme Vilches, Raul Leal Cantu, Ricardo Cabrera Jardines, Nilda Espinola Zavaleta, Enrique Lopez Rosas, Gerardo Pozas, Ernesto Cardona Muñoz, Norberto Matadamas Hernandez, Adolfo Leyva Rendon, Norberto Garcia Hernandez, David Lopez Villezca, Carlos Hernandez Herrera, Rodolfo Gaona Rodriguez, Efrain Villeda Espinosa, David Flores Martinez, Jose Velasco Barcena, Omar Fierro Fierro, Ignacio Rodriguez Briones, Humberto Alvarez Lopez, Rafael Olvera Ruiz, Roxana Reyes Sanchez, Roberto Arriaga Nava, Pedro Fajardo Campos, Mario Benavides Gonzalez, Claus Hagn, Johannes Foechterle, Michael Winkler, Bruno Schneeweiss, Alfons Gegenhuber, Wilfried Lang, Sabine Eichinger-Hasenauer, Peter Kaserer, Josef Sykora, Heribert Rasch, Bernhard Strohmer, Luc Capiau, Geert Vervoort, Bart Wollaert, Geert Hollanders, Dirk Faes, Yohan Balthazar, Olivier Xhaet, Harry Striekwold, John Thoeng, Kurt Hermans, Wim Anné, Ivan Blankoff, Michel Beutels, Stefan Verstraete, Philippe Purnode, Pascal Godart, Tim Boussy, Philippe Desfontaines, Alex Heyse, Joeri Voet, Eva Zidkova, Rudolf Spacek, Vilma Machova, Ondrej Ludka, Josef Olsr, Lubos Kotik, Blazej Racz, Richard Ferkl, Jan Hubac, Ilja Kotik, Zdenek Monhart, Hana Burianova, Ondrej Jerabek, Jana Pisova, Vratislav Dedek, Michaela Honkova, Petr Podrazil, Petr Reichert, Miroslav Novak, Vaclav Durdil, Katarina Plocova, Ulrik Hintze, Næstved Sygehus, Arne Bremmelgaard, John Markenvard, Jan Børger, Jorgen Solgaard, Ebbe Eriksen, Thomas Løkkegaard, Michael Bruun, Jacob Mertz, Joël Ohayon, Yannick Gottwalles, Philippe Loiselet, Mohamed Bassel Koujan, André Marquand, Jean-Pierre Cebron, Maxime Guenoun, Dominique Guedj-Meynier, A G Lokesh, James Kadouch, Pierre-Yves Fournier, Jean-Pierre Huberman, Nestor Lemaire, Gilles Rodier, Xavier Vandamme, Marie Hélène Mahagne, Antoine Mielot, Jean-Baptiste Churet, Vincent Navarre, Frederic Sellem, Gilles Monniot, Jean-Paul Boyes, Désiré Obadia, Etienne Bearez, Jean Philippe Brugnaux, Alain Fedorowsky, Jean-Baptiste Berneau, Frédéric Chemin, Sebastien Schellong, Georg Koeniger, Uwe Gerbaulet, Bernd-Thomas Kellner, Thomas Schaefer, Jan Purr, Enno Eißfeller, Heinz-Dieter Zauzig, Peter Riegel, Christoph Axthelm, Gerd-Ulrich Heinz, Holger Menke, Andreas Pustelnik, Stefan Zutz, Wolfgang Eder, Guenter Rehling, Dirk Glatzel, Norbert Ludwig, Petra Sandow, Henning Wiswedel, Cosmas Wildenauer, Steffen Schoen, Toralf Schwarz, Adyeri Babyesiza, Maximilian Kropp, Hans-Hermann Zimny, Friedhelm Kahl, Andreas Caspar, Sabine Omankowsky, Torsten Laessig, Hermann-Josef Hartmann, Hans-Walter Bindig, Gunter Hergdt, Dietrich Reimer, Joachim Hauk, Holger Michel, Praxis Dres, Werner Erdle, Wilfried Dorsch, Janna Dshabrailov, Karl-Albrecht Rapp, Reinhold Vormann, Thomas Mueller, Uwe Horstmeier, Volker Eissing, Heinz Hey, Heinz Leuchtgens, Volker Lilienweiss, Heiner Mueller, Christian Schubert, Herrmann Lauer, Thomas Buchner, Gunter Brauer, Susanne Kamin, Sylvia Baumbach, Muwafeg Abdel-Qader, Hans-Holger Ebert, Carsten Schwencke, Laszlo Karolyi, Britta Sievers, Jens-Uwe Roehnisch, Andras Vertes, Gabor Szantai, Andras Matoltsy, Nikosz Kanakaridisz, Zoltan Boda, Erno Kis, Balazs Gaszner, Ferenc Juhasz, Gizella Juhasz, Sandor Kancz, Zoltan Laszlo, Zsolt May, Ebrahim Noori, Tamas Habon, Peter Polgar, Gabriella Szalai, Sandor Vangel, Gabriella Engelthaler, Judit Ferenczi, Mihaly Egyutt, Leone Maria Cristina, Eros Tiraferri, Rita Santoro, Teresa Maria Caimi, Maria Tessitori, Roberto Cappelli, Roberto Quintavalla, Franco Cosmi, Raffaele Fanelli, Vincenzo Oriana, Raffaele Reggio, Roberto Santi, Leonardo Pancaldi, Jorge Salerno Uriate, Flavia Lillo, Enrico Maria Pogliani, Michele Accogli, Antonio Mariani, Mauro Feola, Arturo Raisaro, Luciano Fattore, Andrea Mauric, Fabrizio Germini, Luca Tedeschi, Maria Settimi, Sergio Nicoli, Paolo Ricciarini, Antonio Argena, Paolo Ronchini, Claudio Bulla, Filippo Tradati, Maria Grazia Bongiorni, Enrico Salomone, Claudio Tondo, Saverio Iacopino, Andreas Lucassen, Henk Adriaansen, Maarten Bongaerts, Mathijs Pieterse, Johannes Herrman, Pieter Hoogslag, Cees Buiks, Per Anton Sirnes, Erik Gjertsen, Knut Erga, Arne Hallaråker, Gunnar Skjelvan, Beraki Ghezai, Arne Svilaas, Peter Christersson, Svein Høegh Henrichsen, Jan Erik Otterstad, Jan Berg-Johansen, Andrzej Gieroba, Malgorzata Biedrzycka, Michal Ogorek, Beata Wozakowska-Kaplon, Krystyna Loboz-Grudzien, Jerzy Kuzniar, Roman Zaluska, Jaroslaw Hiczkiewicz, Lucyna Swiatkowska-Byczynska, Lech Kucharski, Piotr Minc, Maciej Olszewski, Grzegorz Kania, Malgorzata Krzciuk, Zbigniew Lajkowski, Bozenna Ostrowska-Pomian, Jerzy Lewczuk, Elzbieta Zinka, Agnieszka Karczmarczyk, Malgorzata Chmielnicka-Pruszczynska, Iwona Wozniak-Skowerska, Marek Bronisz, Marcin Ogorek, Grazyna Glanowska, Piotr Ruszkowski, Grzegorz Skonieczny, Ryszard Sciborski, Boguslaw Okopien, Piotr Kukla, Krzysztof Galbas, Krzysztof Cymerman, Jaroslaw Jurowiecki, Pawel Miekus, Stanislaw Mazur, Roman Lysek, Jacek Baszak, Teresa Rusicka-Piekarz, Ewa Domanska, Jozef Lesnik, Gadel Kamalov, Dmitry Belenky, Liudmila Egorova, Alexander Khokhlov, Eduard Yakupov, Dmitry Zateyshchikov, Olga Miller, Evgeniy Mazur, Konstantin Zrazhevskiy, Tatyana Novikova, Yulia Moiseeva, Elena Polkanova, Konstantin Sobolev, Maria Rossovskaya, Yulia Shapovalova, Alla Kolesnikova, Konstantin Nikolaev, Oksana Zemlianskaia, Anna Zateyshchikova, Victor Kostenko, Maria Poltavskaya, Anton Edin, Elena Aleksandrova, Oksana Drapkina, Alexander Vishnevsky, Oleg Nagibovich, Petr Chizhov, Svetlana Rachkova, Mikhail Sergeev, Borys Kurylo, Alexey Ushakov, Pere Alvarez Garcia, Luis Tercedor Sanchez, Salvador Tranche Iparraguirre, Pere Toran Monserrat, Emilio Marquez Contreras, Jordi Isart Rafecas, Juan Motero Carrasco, Casimiro Gomez Pajuelo, Angel Grande Ruiz, Jordi Merce Klein, Ines Monte Collado, Herminia Palacin Piquero, Carles Brotons Cuixart, Esther Fernandez Escobar, Cecilia Corros Vicente, Manuel Vida Gutierrez, Francisco Epelde Gonzalo, Encarnacion Martinez Navarro, Maria Barreda Gonzalez, Jose Iglesias Sanmartin, Mercedes Jimenez Gonzalez, Juan Herreros Melenchon, Tomas Ripoll Vera, Manuel Jimenez Navarro, Maria Vazquez Caamano, Gonzalo Marcos Gomez, Andres Iniguez Romo, Alexander Wirdby, Kerstin Henriksson, Micael Elmersson, Arnor Egilsson, Ulf Börjesson, Gunnar Svärd, Anders Lindh, Lars-Bertil Olsson, Mikael Gustavsson, Lars Benson, Claes Bothin, Ali Hajimirsadeghi, Björn Martinsson, Marianne Ericsson, Åke Ohlsson, Håkan Lindvall, Peter Svensson, Katarina Thörne, Hans Händel, Pyotr Platonov, Fredrik Bernsten, Ingar Timberg, Milita Crisby, Lennart Malmqvist, Jörgen Thulin, Aida Hot-Bjelak, Steen Jensen, Per Stalby, Johann Debrunner, Iurii Rudyk, Oleksandr Karpenko, Svitlana Zhurba, Igor Kraiz, Oleksandr Parkhomenko, Iryna Kupnovytska, Nestor Seredyuk, Oleksiy Ushakov, Olena Koval, Igor Kovalskiy, Yevgeniya Svyshchenko, Susanna Tykhonova, Ivan Fushtey, Naresh Chauhan, Daryl Goodwin, Ramila Patel, Bennett Wong, Alex Cameron, Niranjan Patel, M S Kainth, Gill Pickavance, Joanna McDonnell, Laura Handscombe, Trevor Gooding, Helga Wagner, Catherine Bromham, Shoeb Suryani, Bhupinder Sarai, W Willcock, S Sircar, A Gilliand, Roman Bilas, E Strieder, Anne Wakeman, Graham Kirby, Bhaskhar Vishwanathan, Nigel Bird, John Bisatt, Jennifer Litchfield, Tim Fooks, Richard Kelsall, Neil Paul, Elizabeth Alborough, Michael Aziz, Pete Wilson, Sue Fairhead, Hasan Chowan, Gary Taylor, Dawn Tragen, Matt Parfitt, Claire Seamark, Carolyn Paul, Angus Jefferies, Helen Sharp, Claire Giles, Matthew Bramley, Philip Williams, Jehad Aldegather, William Lumb, Phil Evans, Frances Scouller, Yvette Stipp, Philip Pinney, Paul Wadeson, T Railton, Emyr Davies, Jonathan McClure, Marc Jacobs, Claire Hutton, Keith Butter, Susan Barrow, Helen Little, Ulka Choudhary, Ikram Haq, Paul Ainsworth, Phil Weeks, Jane Eden, Lisa Gibbons, Janet Glencross, K Poland, Conor Mulolland, A Warke, Ian Hodgins, Stephen Vercoe, Jayesh Patel, Amar Ali, Nigel De-Sousa, Mark Danielsen, Purnima Sharma, Sophia Galloway, Charlotte Hawkins, Raife Oliver, Martin Aylward, Mira Pattni, Shahid Ahmad, Catherine Rothwell, Fiaz Choudhary, Sabrina Khalaque, Stephanie Short, Sharon Peters, Amy Butler, Steven Coates, Steve Walton, Diane Shepherd, Toh Wong, Melanie Deacon, David Cornelius, Henry Choi, Jon Sumner, Tim Myhill, Salah Estifanos, Diane Geatch, Justin Wilkinson, Richard Veale, Rob Hirst, Kashif Zaman, Catherine Liley, Rebecca Wastling, Paul McEleny, Andre Beattie, Mike Wong, Chaminda Dooldeniya, Greg Rogers, Rajesh Muvva, Matthew Adam, Nicolas Thomas, Rory Reed, Simon Randfield, Ann Flynn, Andrew Halpin, Louise Lomax, Minnal Nadaph, Iain Munro, Jane Goram, John Shewring, Emma Bowen-Simpkins, Bhuwanendu Singh, Penny Astridge, Philip Thomson, Ron Lehman, Andrei Catanchin, David Eccleston, Peter Blombery, Greg Starmer, Margaret Arstall, Maurits Binnekamp, Astin Lee, Robert Luton, Amritanshu Shekhar Pandey, Stephen Cheung, Rolland Leader, Philippe Beaudry, Félix Ayala-Paredes, John Heath, Germain Poirier, Bradley Schweitzer, Reginald Nadeau, Ripple Dhillon, Tomasz Hruczkowski, Andrea Lavoie, Ratika Parkash, James Cha, Benoit Coutu, Jorge Bonet, Saul Vizel, Sameh Fikry, Ahmed Mowafy, Azza Katta, Mazen Tawfik, Moustafa Nawar, Mohamed Sobhy, Tarek Khairy, Ahmed Abd El-Aziz, Ashraf Reda, Atef Elbahry, Mohamed Setiha, Magdi Elkhadem, Adel El-Etreby, David Kettles, Junaid Bayat, Heidi Siebert, Adrian Horak, Ynez Kelfkens, Riaz Garda, Thayabran Pillay, Michele Guerra, Hendrik Theron, Rikus Louw, Deon Greyling, Pindile Mntla, Siddique Ismail, Fayzal Ahmed, Johannes Engelbrecht, Shambu Maharajh, Veronica Ueckermann, Ghazi Yousef, Munther AlOmairi, Rajan Maruthanayagam, Rupesh Singh, Ahmed Naguib, Amrish Agrawal, Mukesh Nathani, Adel Wassef, Scott Beach, Peter Duffy, Stephen Falkowski, Kevin Ferrick, Miguel Franco, Annette Quick, Vance Wilson, Mark Alberts, Edwin Blumberg, Roddy Canosa, Ted Gutowski, Rodney Ison, Jorge Garcia, Howard Noveck, Pamela Rama, Rajneesh Reddy, Marcus Williams, Keith Ferdinand, Ihsan Haque, Robert Mendelson, Sridevi Pitta, Charles Treasure, Cas Cader, Walter Pharr, Alisha Oropallo, George Platt, Jaspal Gujral, James Welker, Firas Koura, Ajay K. Kakkar, A. John Camm, David A. Fitzmaurice, Keith A.A. Fox, Bernard J. Gersh, Samuel Z. Goldhaber, Lorenzo G. Mantovani, Karen S. Pieper, Alexander G.G. Turpie, Freek W.A. Verheugt, Antonio Carlos PereiraBarretto, Stuart J. Connolly, Jean-Yves Le Heuzey, Jitendra Pal SinghSawhney, Carlos JerjesSánchez Díaz, Hugo Ten Cate, Wael Al Mahmeed, Zhiming Yang Li Xue, A.G. Ravi Shankar, Chiei Takanaka Sen Adachi, Rodolfo AndresAhuad Guerrero, Leonel Adalberto Di Paola, DárioCelestino Sobral Filho, Costantino RobertoFrack Costantini, Weimar Kunz SebbaBarrosodeSouzaem, João David deSouzaNeto, José Carlos MouraJorge, Adalberto MenezesLorga Filho, Carlos Henrique DelCarlo, FernandoAugustoAlves da Costa, Gilson Robertode Araújo, Jose FranciscoKerr Saraiva, João CarlosFerreira Braga, Roberto Álvaro RamosFilho, Cláudio MunhozdaFontoura Tavares, CésarCássio Broilo França, Guido BernardoAranha Rosito, João BatistadeMouraXavierMoraes Junior, Roberto Simõesde Almeida, Ney CarterdoCarmo Borges, LuísGustavo Gomes Ferreira, Benjamin AleckJosehStockins Fernandez, CarlosJerjes Sanchez Diaz, Jesus JaimeIllescas Diaz, Maria GuadalupeRamos Zavala, GuillermoAntonio Llamas Esperón, Manuel delosRios Ibarra, LuisRamon Virgen Carrillo, JuanJose Lopez Prieto, Jose LuisLeiva Pons, Carlos GerardoCantu Brito, EduardoJulianJose Roberto ChuquiureValenzuela, Alberto EstebanBazzoni Ruiz, Oscar MartinLopez Ruiz, Jesus DavidMorales Cerda, Axel De Wolf, Carmela Viitanen, Giovanni Di Minno, Raimondo De Cristofaro, Angelo De Blasio, Maria D'Avino, J.H. Ruiter, Coen van Guldener, P.R. Nierop S.H.K., B.E. Groenemeijer, W. Terpstra, L.V.A. Boersma, Wieslaw Supinski Jaroslaw, Roman Libis Vera Eltishcheva, Maria FernandaLopez Fernandez, Luis MiguelRincon Diaz, Luis FernandoIglesias Alonso, Jose RamonGonzalez Juanatey, Joan Bayo iLlibre, Carlos AlexandreAlmeida Fernandez, Juan JoseMontero Alia, Maria AngelsMoleiro Oliva, Maria delMarRodriguez Alvarez, Maria FeArcocha Torres, Miguel AngelPrieto Diaz, Jan Lindén Centrumkliniken, Juerg H. Beer, Colin Bradshaw Cumberlidge, Daniel Jackson Ben Ward, Nick Hargreaves Ben Frankel, William van Gaal, David O'Donnell, Miranda du Preez, Seif Kamal Abou Seif, Mohamed Gamal El Din, Louis van Zyl, Rehana Loghdey Wessel Oosthuysen, Abdullah Al Naeemi, Ehab M. Esheiba, and W. Michael Kutayli
Subjects: Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Objective While greater body mass index (BMI) is associated with increased risk of developing atrial fibrillation (AF), the impact of BMI on outcomes in newly diagnosed AF is unclear. We examine the influence of BMI on outcomes and whether this is modified by sex and evaluate the effect of non-vitamin K oral anticoagulants (NOACs) in patients with high BMI.Methods GARFIELD-AF is a prospective registry of 52 057 newly diagnosed AF patients. The study population comprised 40 482 participants: 703 underweight (BMI
Published: 2022
Full Text: View/download PDF

7. Social Isolation of Older Adults With Diabetes

Author: Satoshi Ida MD, MPH and Kazuya Murata MD, PhD
Subjects: Geriatrics, RC952-954.6
Abstract: We aimed to conduct a scoping review of social isolation in elderly patients with diabetes and to clarify current knowledge and gaps and future challenges. A literature search was conducted using Medline, Web of Science, CINAHL, CiNii, and Ichushi, and included studies with an eligibility criterion of a survey of social isolation in elderly patients with diabetes and aged ≥60 years. Social isolation was defined as limited or non-face-to-face contact with family and community. A data extraction form describing characteristics of studies incorporated in the present review was prepared. A total of six studies met eligibility criterion (sample size, 451–3,500). Subjects’ age averaged 67 years, and 42% were female. Social isolation ranged from 9% to 49%. Factors related to social isolation included vascular complications,decreased activities of daily living, death, dementia, glycemic fluctuation, disturbance of lifestyle habits, and poor self-management and -rated health. However, research on the cause and mechanism of the relationship and impact of sex-based differences was lacking. In conclusion, additional research is needed on the definition of social isolation in elderly patients with diabetes, the causal relationship with related factors and their mechanisms, and the relationship with other outcomes.
Published: 2022
Full Text: View/download PDF

8. Social Participation Benefit in Elderly Patients With Diabetes: A Scoping Review

Author: Satoshi Ida MD, MPH and Kazuya Murata MD, PhD
Subjects: Geriatrics, RC952-954.6
Abstract: Aims: To conduct a scoping review on the proportion of social participation in elderly patients with diabetes and related factors to clarify what is known and what needs to be addressed in the future. Methods: Literature searches were conducted using MEDLINE, Web of Science, CINAHL, CiNii, and Ichu-shi. Articles that surveyed social participation in elderly patients with diabetes were included. Social participation was defined as participation in community activities/groups (exercise, sports, hobbies, volunteer activities, neighborhood associations, senior citizens associations, and political and religious organizations). Results: The mean age of the subjects was 67 years, and 42% were women. The percentage of social participation was 13%–36%. Moreover, factors contributing to social participation included self-management of treatment, lifestyle, mobility, subjective assessment of health, and quality of life. Conclusion: This study showed the percentage of social participation in elderly patients with diabetes and related factors. Further study is required to evaluate the causal relationship, the mechanism between social participation and contributing factors, the relationship between social participation and other outcomes, and several stratified analyses in elderly patients with diabetes.
Published: 2022
Full Text: View/download PDF

9. DAJIN enables multiplex genotyping to simultaneously validate intended and unintended target genome editing outcomes.

Author: Akihiro Kuno, Yoshihisa Ikeda, Shinya Ayabe, Kanako Kato, Kotaro Sakamoto, Sayaka R Suzuki, Kento Morimoto, Arata Wakimoto, Natsuki Mikami, Miyuki Ishida, Natsumi Iki, Yuko Hamada, Megumi Takemura, Yoko Daitoku, Yoko Tanimoto, Tra Thi Huong Dinh, Kazuya Murata, Michito Hamada, Masafumi Muratani, Atsushi Yoshiki, Fumihiro Sugiyama, Satoru Takahashi, and Seiya Mizuno
Subjects: Biology (General), QH301-705.5
Abstract: Genome editing can introduce designed mutations into a target genomic site. Recent research has revealed that it can also induce various unintended events such as structural variations, small indels, and substitutions at, and in some cases, away from the target site. These rearrangements may result in confounding phenotypes in biomedical research samples and cause a concern in clinical or agricultural applications. However, current genotyping methods do not allow a comprehensive analysis of diverse mutations for phasing and mosaic variant detection. Here, we developed a genotyping method with an on-target site analysis software named Determine Allele mutations and Judge Intended genotype by Nanopore sequencer (DAJIN) that can automatically identify and classify both intended and unintended diverse mutations, including point mutations, deletions, inversions, and cis double knock-in at single-nucleotide resolution. Our approach with DAJIN can handle approximately 100 samples under different editing conditions in a single run. With its high versatility, scalability, and convenience, DAJIN-assisted multiplex genotyping may become a new standard for validating genome editing outcomes.
Published: 2022
Full Text: View/download PDF

10. Relationship between frailty and mortality, hospitalization, and cardiovascular diseases in diabetes: a systematic review and meta-analysis

Author: Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, and Kazuya Murata
Subjects: Comorbidities, Elderly, Frailty, Mortality, Meta-analysis, Cardiovascular disease, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract Background In patients with diabetes, death and cardiovascular diseases are attributed to classical risk factors such as hypertension, dyslipidemia, and smoking habit, whereas these events are attributed to frailty in the remaining patients. In this meta-analysis, we examined the relationship between frailty and mortality, hospitalization, and cardiovascular diseases in patients with diabetes. Methods Literature search was conducted using databases such as MEDLINE, Cochrane Controlled Trials Registry, and ClinicalTrials.gov. Studies that examined the relationship between frailty and mortality, hospitalization, and cardiovascular disease and included hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were included. Statistical analysis was performed using a random effects model, and pooled HRs, pooled ORs, and 95% CIs were calculated. Results The literature search extracted 8 studies (565,039 patients) that met our inclusion criteria, which were included in this meta-analysis. The pooled HR of prefrailty and frailty related to mortality was 1.09 (95% CI 1.01–1.17; P = 0.02) and 1.35 (95% CI 1.05–1.74; P = 0.02), respectively, indicating a significant relationship between them. The pooled OR of prefrailty and frailty related to hospitalization was 2.15 (95% CI 1.30–3.54; P = 0.003) and 5.18 (95% CI 2.68–9.99; P
Published: 2019
Full Text: View/download PDF

11. Efficacy and safety of pemafibrate administration in patients with dyslipidemia: a systematic review and meta-analysis

Author: Satoshi Ida, Ryutaro Kaneko, and Kazuya Murata
Subjects: Fibrate, Meta-analysis, Dyslipidemia, Pemafibrate, Adverse events, Lipid profile, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract Background Using a meta-analysis of randomized controlled trials (RCTs), this study aimed to investigate the efficacy and safety of pemafibrate, a novel selective peroxisome proliferator-activated receptor α modulator, in patients with dyslipidemia. Methods A search was performed using the MEDLINE, Cochrane Controlled Trials Registry, and ClinicalTrials.gov databases. We decided to employ RCTs to evaluate the effects of pemafibrate on lipid and glucose metabolism-related parameters in patients with dyslipidemia. For statistical analysis, standardized mean difference (SMD) or odds ratio (OR) and 95% confidence intervals (CIs) were calculated using the random effect model. Results Our search yielded seven RCTs (with a total of 1623 patients) that satisfied the eligibility criteria of this study; hence, those studies were incorporated into this meta-analysis. The triglyceride concentration significantly decreased in the pemafibrate group (SMD, − 1.38; 95% CI, − 1.63 to − 1.12; P
Published: 2019
Full Text: View/download PDF

12. EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice

Author: Yuki Osawa, Kazuya Murata, Miho Usui, Yumeno Kuba, Hoai Thu Le, Natsuki Mikami, Toshinori Nakagawa, Yoko Daitoku, Kanako Kato, Hossam Hassan Shawki, Yoshihisa Ikeda, Akihiro Kuno, Kento Morimoto, Yoko Tanimoto, Tra Thi Huong Dinh, Ken-ichi Yagami, Masatsugu Ema, Shosei Yoshida, Satoru Takahashi, Seiya Mizuno, and Fumihiro Sugiyama
Subjects: spermatogenesis, exocyst complex, cell morphology, Medicine, Science, Biology (General), QH301-705.5
Abstract: The male germ cells must adopt the correct morphology at each differentiation stage for proper spermatogenesis. The spermatogonia regulates its differentiation state by its own migration. The male germ cells differentiate and mature with the formation of syncytia, failure of forming the appropriate syncytia results in the arrest at the spermatocyte stage. However, the detailed molecular mechanisms of male germ cell morphological regulation are unknown. Here, we found that EXOC1, a member of the Exocyst complex, is important for the pseudopod formation of spermatogonia and spermatocyte syncytia in mice. EXOC1 contributes to the pseudopod formation of spermatogonia by inactivating the Rho family small GTPase Rac1 and also functions in the spermatocyte syncytia with the SNARE proteins STX2 and SNAP23. Since EXOC1 is known to bind to several cell morphogenesis factors, this study is expected to be the starting point for the discovery of many morphological regulators of male germ cells.
Published: 2021
Full Text: View/download PDF

13. Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway

Author: Tra Thi Huong Dinh, Hiroyoshi Iseki, Seiya Mizuno, Saori Iijima-Mizuno, Yoko Tanimoto, Yoko Daitoku, Kanako Kato, Yuko Hamada, Ammar Shaker Hamed Hasan, Hayate Suzuki, Kazuya Murata, Masafumi Muratani, Masatsugu Ema, Jun-Dal Kim, Junji Ishida, Akiyoshi Fukamizu, Mitsuyasu Kato, Satoru Takahashi, Ken-ichi Yagami, Valerie Wilson, Ruth M Arkell, and Fumihiro Sugiyama
Subjects: cables2, embryonic lethality, gastrulation, p53, Rps21, Wnt/beta-catenin, Medicine, Science, Biology (General), QH301-705.5
Abstract: In vivo function of CDK5 and Abl enzyme substrate 2 (Cables2), belonging to the Cables protein family, is unknown. Here, we found that targeted disruption of the entire Cables2 locus (Cables2d) caused growth retardation and enhanced apoptosis at the gastrulation stage and then induced embryonic lethality in mice. Comparative transcriptome analysis revealed disruption of Cables2, 50% down-regulation of Rps21 abutting on the Cables2 locus, and up-regulation of p53-target genes in Cables2d gastrulas. We further revealed the lethality phenotype in Rps21-deleted mice and unexpectedly, the exon 1-deleted Cables2 mice survived. Interestingly, chimeric mice derived from Cables2d ESCs carrying exogenous Cables2 and tetraploid wild-type embryo overcame gastrulation. These results suggest that the diminished expression of Rps21 and the completed lack of Cables2 expression are intricately involved in the embryonic lethality via the p53 pathway. This study sheds light on the importance of Cables2 locus in mouse embryonic development.
Published: 2021
Full Text: View/download PDF

14. Presence of non-pulmonary vein foci in patients with atrial fibrillation undergoing standard ablation of pulmonary vein isolation: Clinical characteristics and long-term ablation outcome

Author: Yukihiro Inamura, Junichi Nitta, Osamu Inaba, Akira Sato, Tomomasa Takamiya, Kazuya Murata, Takashi Ikenouchi, Toshikazu Kono, Yutaka Matsumura, Yoshihide Takahashi, Masahiko Goya, and Tetsuo Sasano
Subjects: Catheter ablation, Atrial fibrillation, Pulmonary vein isolation, Non-pulmonary vein foci, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Background: The clinical characteristics of atrial fibrillation (AF) resulting from non-pulmonary vein (PV) triggers remain unknown. This study aimed to evaluate the clinical characteristics of patients with AF caused by non-PV triggers, localization of non-PV foci, clinical differences, and clinical outcomes after catheter ablation in each AF focus. Methods: A total of 2967 patients who underwent initial catheter ablation for paroxysmal or persistent AF were examined. After PV isolation, all patients underwent high-dose isoproterenol infusion to assess the existence of non-PV foci. Results: Non-PV foci were identified in 564 patients (19.2%). The localization of successfully ablated non-PV foci in 514 patients were the superior vena cava (SVC: 213 cases), interatrial septum (IAS: 125 cases), coronary sinus (CS: 98 cases), right atrium (RA: 125 cases), left atrium (LA: 114 cases), and unmappable (50 cases). Multivariate analysis revealed that female gender, low body mass index (BMI), non-paroxysmal AF (PAF), and sick sinus syndrome were independent and significant indicators of non-PV foci. In the multivariate analysis of each AF focus, female gender, low BMI, and non-PAF were significant predictors of IAS and CS foci, RA and IAS foci, and CS foci, respectively. In addition, dilatation of the LA was significantly associated with LA foci, whereas RA, LA, IAS, and CS foci were associated with AF recurrence. Conclusion: These findings could help to identify patients at a higher risk of AF caused by non-PV triggers and clarify the clinical difference according to the localization of non-PV foci.
Published: 2021
Full Text: View/download PDF

15. Tyrosinase Inhibitory Activity of Extracts from Prunus persica

Author: Kazuya Murata, Satomi Suzuki, Akane Miyamoto, Miki Horimoto, Suzuna Nanko, Daisuke Mori, Hiroshi Kanamaru, and Yuichi Endo
Subjects: Prunus persica, flavonoid, tyrosinase, persiconin, (−)-prunin, (+)-dihydrokaempferol, Physics, QC1-999, Chemistry, QD1-999
Abstract: The demand for skin-whitening agents is high across the world, including Asian countries. An extensive screening using a tyrosinase inhibition assay was performed in order to discover novel plant materials. In our research program investigating a safe and effective agent, 50% ethanolic extracts prepared from discarded parts of Prunus persica were screened for in vitro tyrosinase inhibitory activity. Among the extracts tested, twig extract showed the most potent inhibitory activity: 38% inhibition at 500 µg/mL. The investigation of active compounds in twig extract found four flavanones that acted as moderate inhibitors, including (−)-prunin, persiconin, (+)-dihydrokaempferol, and (−)-naringenin. These compounds were only observed in the twig extract following preliminary quantification by HPLC, with the following concentrations: (−)-prunin, 1.8 mg/g sample; persiconin, 0.8 mg/g sample; (+)-dihydrokaempferol, 0.8 mg/g sample; (−)-naringenin, 1.7 mg/g sample. These results suggest that twig extracts can be more useful for skin-whitening compared with other parts of the plant. In addition, a new constituent of twig extract was identified, namely isoquercitrin, which suggests that twig extract can be a potent source of flavones and flavanones. Further studies on the identification of novel compounds from twig extract are now underway in our laboratory.
Published: 2022
Full Text: View/download PDF

16. Factors associated with social isolation and being homebound among older patients with diabetes: a cross-sectional study

Author: Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, Kaoru Okubo, Yoshitaka Shirakura, Kentaro Azuma, Ryoko Fujiwara, Hiroka Takahashi, and Kazuya Murata
Subjects: Medicine
Abstract: Objective We aimed at investigating factors associated with social isolation and being homebound in older patients with diabetes.Design Cross-sectional study.Settings Those undergoing outpatient treatments at Ise Red Cross Hospital, Mie Prefecture.Participants Patients with diabetes aged ≥65 years.Primary and secondary outcome measures Social isolation was defined as indulging in less than one interaction per week with individuals other than cohabiting family members. We defined homebound as going outside home less than once a day. To identify factors associated with social isolation and being homebound, we performed logistic regression analysis. The dependent variable was social isolation or homebound and independent variables were basic attributes, glycaemic parameters, complications and treatment details.Results We analysed 558 cases (320 men and 238 women). Among these, 174 (31.2%) were socially isolated; meanwhile, 87 (15.6%) were homebound. The glycoalbumin/haemoglobin A1c ratio (OR 4.52; 95% CI 1.07 to 19.1; p=0.040) and the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC) scores (OR 0.72; 95% CI 0.57 to 0.90; p=0.006) had significant associations with social isolation. TMIG-IC scores (OR 0.78; 95% CI 0.66 to 0.92; p=0.003) and insulin use (OR 4.29; 95% CI 1.14 to 16.1; p=0.031) were associated with being homebound.Conclusion In older patients with diabetes, glycaemic fluctuations and insulin use are associated with social isolation and being homebound, respectively. In addition, a decline in higher level functional capacity is a common factor associated with social isolation and being homebound. Thus, it is important to pay attention to social isolation and being homebound when a decline in higher level functional capacity, increased glycaemic fluctuations and insulin use in older patients with diabetes are observed.
Published: 2020
Full Text: View/download PDF

17. Effects of Flash Glucose Monitoring on Dietary Variety, Physical Activity, and Self-Care Behaviors in Patients with Diabetes

Author: Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, Kaoru Okubo, Yoshitaka Shirakura, Kentaro Azuma, Ryoko Hujiwara, Hiroka Takahashi, and Kazuya Murata
Subjects: Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: The aim of this study was to evaluate the effects of flash glucose monitoring on dietary variety, physical activity, and self-care behavior in patients with diabetes. This study included outpatients with diabetes using insulin who presented at the Department of Diabetes and Metabolism of the Ise Red Cross Hospital. Before initiating flash glucose monitoring and 12 weeks after its initiation, blood glucose-related parameters were assessed and self-administered questionnaires were completed (Dietary Variety Score (DVS), the International Physical Activity Questionnaire (IPAQ), the Summary of Diabetes Self-Care Activities Measure (SDSCA), and the Diabetes Treatment Satisfaction Questionnaire (DTSQ)) and compared between the two time points. We analyzed 42 patients with type 1 diabetes mellitus and 48 patients with type 2 diabetes mellitus. In patients with type 2 diabetes mellitus, but not type 1 diabetes mellitus, there was an increase in moderate/high category scores for IPAQ (P
Published: 2020
Full Text: View/download PDF

18. Preparation, Reliability, and Validity of a Japanese Version of the 'Satisfaction of Treatment among Caregivers of Dependent Type 2 Diabetic Patients' Questionnaire

Author: Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, Kaoru Okubo, Yoshitaka Shirakura, Kentaro Azuma, Ryoko Fujiwara, Hiroka Takahashi, and Kazuya Murata
Subjects: Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: The aim of this study was to prepare a Japanese version of the “Satisfaction of Treatment among Caregivers of Dependent Type 2 Diabetic Patients” (STCD2-J) questionnaire, which is used to assess the satisfaction of family caregivers with respect to the treatment for elderly patients with type 2 diabetes mellitus who require support. In addition, the reliability and validity of the STCD2-J questionnaire were analyzed. A Japanese version of the original STCD2 questionnaire was prepared, revised, and back-translated; the back-translated version was sent to the authors of the original version for confirmation. Family caregivers of patients with type 2 diabetes mellitus aged ≥65 years who regularly underwent medical examinations at the diabetes mellitus outpatient clinic of Ise Red Cross Hospital were included. Cronbach’s α coefficient was calculated to assess internal consistency. Exploratory factor analyses were performed to assess construct validity, and Pearson’s correlation coefficients between STCD2-J score and HbA1c as well as the degree of satisfaction with patients’ blood glucose levels, depression, and negative self-assessment of nursing care were calculated to assess criterion-related validity. This study included 208 individuals (55 males and 153 females). Cronbach’s α coefficient was 0.88. Factor analyses showed a single-factor structure both with and without rotation. The STCD2-J scores were significantly inversely correlated with HbA1c (r=−0.27, P
Published: 2020
Full Text: View/download PDF

19. PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products

Author: Kazuya Murata, Weizhe Lu, Misuzu Hashimoto, Natsumi Ono, Masafumi Muratani, Kana Nishikata, Jun-Dal Kim, Shizufumi Ebihara, Junji Ishida, and Akiyoshi Fukamizu
Subjects: Science
Abstract: Summary: Protein arginine methyltransferase 1 (PRMT1) catalyzes the asymmetric dimethylation of arginine residues in proteins and methylation of various RNA-binding proteins and is associated with alternative splicing in vitro. Although PRMT1 has essential in vivo roles in embryonic development, CNS development, and skeletal muscle regeneration, the functional importance of PRMT1 in the heart remains to be elucidated. Here, we report that juvenile cardiomyocyte-specific PRMT1-deficient mice develop severe dilated cardiomyopathy and exhibit aberrant cardiac alternative splicing. Furthermore, we identified previously undefined cardiac alternative splicing isoforms of four genes (Asb2, Fbxo40, Nrap, and Eif4a2) in PRMT1-cKO mice and revealed that eIF4A2 protein isoforms translated from alternatively spliced mRNA were differentially ubiquitinated and degraded by the ubiquitin-proteasome system. These findings highlight the essential roles of PRMT1 in cardiac homeostasis and alternative splicing regulation. : Genetics; Molecular Biology; Cell Biology; Developmental Biology Subject Areas: Genetics, Molecular Biology, Cell Biology, Developmental Biology
Published: 2018
Full Text: View/download PDF

20. Effects of oral antidiabetic drugs on left ventricular mass in patients with type 2 diabetes mellitus: a network meta-analysis

Author: Satoshi Ida, Ryutaro Kaneko, and Kazuya Murata
Subjects: Antidiabetic drugs, Network meta-analysis, Randomized controlled trials, Type 2 diabetes mellitus, Left ventricular mass, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract Background We used a network meta-analysis of randomized controlled trials (RCTs) to comparatively examine the effects of oral antidiabetic drugs (OADs) on left ventricular mass (LVM) in patients with type 2 diabetes. Methods Document searches were implemented using Medline, Cochrane Controlled Trials Registry, and ClinicalTrials.gov. We decided to include RCTs that evaluated the impact of LVM using the administration of OADs to patients with type 2 diabetes. The outcome evaluations used standardized mean difference (SMD) and 95% confidence intervals (CIs). We then performed a comparative examination of LVM related to the administration of OADs using random effects network meta-analysis. Results The document search found 11 RCTs (1410 people) that satisfied the eligibility criteria for this study, and these RCTs were incorporated into the network meta-analysis. The only medication that significantly reduced LVM compared to a placebo was gliclazide (SMD, −1.09; 95% CI, −1.62 to − 0.57). Further, when comparing the impact on LVM between OADs, only gliclazide significantly reduced LVM compared to other OADs (glyburide, voglibose, metformin, pioglitazone, rosiglitazone, and sitagliptin). Conclusions In the present study, gliclazide was the only medication that significantly reduced LVM in patients with type 2 diabetes. When considered from the perspective of causing heart failure and preventing recurrence, it is possible that the use of gliclazide in patients with type 2 diabetes will provide multiple benefits.
Published: 2018
Full Text: View/download PDF

21. Isolation of biologically active peptides from the venom of Japanese carpenter bee, Xylocopa appendiculata

Author: Hiroko Kawakami, Shin G. Goto, Kazuya Murata, Hideaki Matsuda, Yasushi Shigeri, Tomohiro Imura, Hidetoshi Inagaki, and Tetsuro Shinada
Subjects: Xylocopa appendiculata, Carpenter bee, Venom peptides, Solitary bee, Mass spectrometry analysis, Arctic medicine. Tropical medicine, RC955-962, Toxicology. Poisons, RA1190-1270, Zoology, QL1-991
Abstract: Abstract Background Mass spectrometry-guided venom peptide profiling is a powerful tool to explore novel substances from venomous animals in a highly sensitive manner. In this study, this peptide profiling approach is successfully applied to explore the venom peptides of a Japanese solitary carpenter bee, Xylocopa appendiculata (Hymenoptera: Apoidea: Apidae: Anthophila: Xylocopinae: Xylocopini). Although interesting biological effects of the crude venom of carpenter bees have been reported, the structure and biological function of the venom peptides have not been elucidated yet. Methods The venom peptide profiling of the crude venom of X. appendiculata was performed by matrix-assisted laser desorption/ionization-time of flight mass spectroscopy. The venom was purified by a reverse-phase HPLC. The purified peptides were subjected to the Edman degradation, MS/MS analysis, and/or molecular cloning methods for peptide sequencing. Biological and functional characterization was performed by circular dichroism analysis, liposome leakage assay, and antimicrobial, histamine releasing and hemolytic activity tests. Results Three novel peptides with m/z 16508, 1939.3, and 1900.3 were isolated from the venom of X. appendiculata. The peptide with m/z 16508 was characterized as a secretory phospholipase A2 (PLA2) homolog in which the characteristic cysteine residues as well as the active site residues found in bee PLA2s are highly conserved. Two novel peptides with m/z 1939.3 and m/z 1900.3 were named as Xac-1 and Xac-2, respectively. These peptides are found to be amphiphilic and displayed antimicrobial and hemolytic activities. The potency was almost the same as that of mastoparan isolated from the wasp venom. Conclusion We found three novel biologically active peptides in the venom of X. appendiculata and analyzed their molecular functions, and compared their sequential homology to discuss their molecular diversity. Highly sensitive mass analysis plays an important role in this study.
Published: 2017
Full Text: View/download PDF

22. Association between Sarcopenia and Renal Function in Patients with Diabetes: A Systematic Review and Meta-Analysis

Author: Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, and Kazuya Murata
Subjects: Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Previous studies involving patients with diabetes have indicated that sarcopenia is related to renal function. The objective of the present study was to investigate the association between sarcopenia and urinary albumin level, urinary protein level, and estimated glomerular filtration rate (eGFR) in patients with diabetes. A meta-analysis of observational studies was conducted. A literature search was performed using MEDLINE, Cochrane Controlled Trials Registry, and ClinicalTrials.gov. Data were extracted from studies investigating the association between sarcopenia and urinary albumin level, urinary protein level, and eGFR and by calculating odds ratio (OR) and 95% confidence intervals (CIs). Statistical analysis was performed using a random-effects model to calculate pooled OR and 95% CI. Six studies (2662 patients) that met the criteria were included in the meta-analysis. Sarcopenia was significantly associated with urinary albumin level with a pooled OR of 2.11 (95% CI, 1.55–2.88; P
Published: 2019
Full Text: View/download PDF

23. Utility of Real-Time and Retrospective Continuous Glucose Monitoring in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials

Author: Satoshi Ida, Ryutaro Kaneko, and Kazuya Murata
Subjects: Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: In the present study, we aimed to investigate the effects of continuous glucose monitoring (CGM) on blood glucose levels, body weight, blood pressure, and hypoglycaemia in patients with type 2 diabetes mellitus using a meta-analysis of randomized controlled trials (RCTs). A literature search was performed using MEDLINE, Cochrane Controlled Trials Registry, and ClinicalTrials.gov. RCTs using CGM in patients with type 2 diabetes mellitus were then selected. Statistical analysis included calculation of the standardized mean difference (SMD) or risk ratio and 95% confidence intervals (CIs) using a random effects model. After literature search, seven RCTs (669 patients) satisfied the eligibility criteria established herein and were included into the meta-analysis. Compared with the self-monitoring blood glucose group, the CGM group exhibited significantly lower HbA1c levels (SMD, −0.35; 95% CI, −0.59–−0.10; P=0.006) and shorter time spent with hypoglycaemia (SMD, −0.42; 95% CI, −0.70–−0.13; P=0.004). Conversely, no differences in body weight and blood pressure were observed between the groups. CGM in patients with type 2 diabetes mellitus could reduce HbA1c levels and time spent with hypoglycaemia. However, because few RCTs were included in this present study and heterogeneity was also noted, care should be taken when interpreting the results.
Published: 2019
Full Text: View/download PDF

24. Successful Percutaneous Coronary Intervention for Atherosclerotic Coronary Lesion with Anomalous Origin of the Right Coronary Artery

Author: Junji Matsuda, Takashi Ikenouchi, Giichi Nitta, Shunichi Kato, Kazuya Murata, Miki Kanoh, Yukihiro Inamura, Nobutaka Kato, Tomomasa Takamiya, Ken Negi, Akira Sato, Tsunehiro Yamato, Yutaka Matsumura, and Junichi Nitta
Subjects: Medicine
Abstract: Congenital coronary artery anomalies, including anomalous origin of a coronary artery, can manifest as life-threatening conditions, such as myocardial infarction or arrhythmia, and may even lead to sudden death associated with specific congenital anatomical features. Such arteries can also develop atherosclerotic lesions. This report describes the case of a 75-year-old man who was admitted to our hospital due to exertional dyspnea. The right coronary artery was found to originate from the left coronary sinus and exhibit tight stenosis due to atherosclerosis, causing effort angina pectoris. This case highlights the fact that coronary artery anomalies can cause angina pectoris via both atherosclerotic and nonatherosclerotic effects, and successful revascularization was achieved noninvasively via percutaneous coronary angioplasty.
Published: 2018
Full Text: View/download PDF

25. Chemiluminescent Receptor Binding Assay for Ciguatoxins and Brevetoxins Using Acridinium Brevetoxin-B2

Author: Kazuya Murata and Takeshi Yasumoto
Subjects: ciguatera, ciguatoxins, neurotoxic shellfish poisoning, brevetoxins, acridinium ligand, chemiluminescent binding assay, synaptosome, Medicine
Abstract: Ciguatera is the term for poisoning resulting from eating fish from tropical or subtropical regions. The causative toxins collectively named ciguatoxins (CTXs) widely differ in structures depending on their geographic origins, which range from the Pacific Ocean and the Indian Ocean to the Caribbean Sea. Neurotoxic shellfish poisoning (NSP) is caused by the ingestion of bivalve shellfish contaminated with brevetoxins (BTXs). Structurally, both CTXs and BTXs consist of fused ether rings aligned in a ladder shape. Pharmacologically, they bind at the same site (site-5) of voltage-gated sodium channels. However, the great structural diversity and the rare availability of reference toxins hinder LC-MS and ELISA methods, which operate on structure-based recognition. In this study, we prepared a chemiluminescent ligand, acridinium BTXB2 (ABTX), and tested its suitability for use in competitive binding assays to detect CTXs and BTXs. The affinity of ABTX to the rat brain synaptosome estimated by Ki (1.66 pM) was approximately two-fold higher than that of PbTx-3 (BTX3). In addition, the equilibrium dissociation constant (KD) was 0.84 nM, the maximum number of binding was 6.76 pmol toxin/mg protein, and the detection limit was 1.4 amol. The assays performed on samples spiked with CTX3C or BTXB4 (N-palmitoylBTXB2) at 0.2−1.0 ng CTX/g fish flesh, and 200−800 ng BTXB4/g shellfish showed a linear relationship between the theoretical and observed toxin amounts.
Published: 2019
Full Text: View/download PDF

26. Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice.

Author: Natsuki MIKAMI, Chi Lieu Kim NGUYEN, Yuki OSAWA, Kanako KATO, Miyuki ISHIDA, Yoko TANIMOTO, Kento MORIMOTO, Kazuya MURATA, Woojin KANG, Fumihiro SUGIYAMA, Masatsugu EMA, Satoru TAKAHASI, and Seiya MIZUNO
Published: 2024
Full Text: View/download PDF

27. Design of Interactive Remote Class Environment by 'Infrastructure-Based Low-Cost Computing'.

Author: Kazuya Murata
Published: 2019
Full Text: View/download PDF

28. A Proposal for 'Infinite Scale' Ruler Application that Provides Analog-Like 'Sensory Reality'.

Author: Kazuya Murata, Eigo Ito, and Takayuki Fujimoto
Published: 2018
Full Text: View/download PDF

29. 'Multiple Sightseeing Scheduling System' Enabling Tourist Guidance Specialized for Time Performance.

Author: Kazuya Murata and Takayuki Fujimoto
Published: 2019
Full Text: View/download PDF

30. 腰臍テスト：内臓脂肪型肥満に対する新しいスクリーニング法

Author: Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, Kaoru Okubo, Kentaro Azuma, and Kazuya Murata
Subjects: Geriatrics and Gerontology
Published: 2023
Full Text: View/download PDF

31. Development of 'Multiple Sightseeing Spot Scheduling System' and Evaluation Experiment.

Author: Kazuya Murata and Takayuki Fujimoto
Published: 2017
Full Text: View/download PDF

32. THE TRANSFORMATION OF PLAN AS THE MAIN-HOUSE FOR THE NAKATANI-FAMILY IN THE OKUNOTO REGION

Author: Kazuya MURATA and Ikuo HIRAYAMA
Subjects: General Medicine
Published: 2023
Full Text: View/download PDF

33. A study of the frequency of cachexia and its associated factors in elderly patients with diabetes mellitus

Author: Satoshi Ida, Kazuya Murata, Kaoru Okubo, Kanako Imataka, Kentaro Azuma, Ryutaro Kaneko, and Ryoko Fujiwara
Subjects: Geriatrics and Gerontology
Published: 2023
Full Text: View/download PDF

34. Retrograde fast pathway cryoablation inside the coronary sinus for slow‐fast atrioventricular nodal reentrant tachycardia in a patient with persistent left superior vena cava

Author: Hirofumi Arai, Rena Nakamura, Yuichiro Sagawa, Atsuhito Oda, Kazuya Murata, Kaoru Okishige, Masahiko Goya, Tetsuo Sasano, Kazutaka Aonuma, and Yasuteru Yamauchi
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Published: 2023
Full Text: View/download PDF

35. Cold start cycling durability of fuel cell stacks for commercial automotive applications

Author: Tsuyoshi Takahashi, Yohsuke Kokubo, Kazuya Murata, Osamu Hotaka, Shigeki Hasegawa, Yuya Tachikawa, Masamichi Nishihara, Junko Matsuda, Tatsumi Kitahara, Stephen M. Lyth, Akari Hayashi, and Kazunari Sasaki
Subjects: Fuel Technology, Renewable Energy, Sustainability and the Environment, Energy Engineering and Power Technology, Condensed Matter Physics
Published: 2022
Full Text: View/download PDF

36. Proposal of Multiple Travel Scheduling System based on Inverse Operation Method.

Author: Kazuya Murata and Takayuki Fujimoto
Published: 2015
Full Text: View/download PDF

37. GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide

Author: Sylvia, H, John A, C, Darius, H, Jan, S, Saverio, V, Karen, P, Marianne, B, Sebastian, S, Frank, M, Gloria, K, Kakkar, A, Bassand, J, John Camm, A, Fitzmaurice, D, Fox, K, Gersh, B, Goldhaber, S, Goto, S, Haas, S, Hacke, W, Mantovani, L, Misselwitz, F, Pieper, K, Turpie, A, van Eickels, M, Verheugt, F, Gersh, K, Lucas Luciardi Harry Gibbs, H, Brodmann, M, Cools, F, Carlos Pereira Barretto, A, Connolly, S, Eikelboom, J, Corbalan, R, Jing, Z, Jansky, P, Dalsgaard Nielsen, J, Ragy, H, Raatikainen, P, Le Heuzey, J, Keltai, M, Pal Singh Sawhney, J, Agnelli, G, Ambrosio, G, Koretsune, Y, Jerjes Sánchez Díaz, C, Ten Cate, H, Atar, D, Stepinska, J, Panchenko, E, Wei Lim, T, Jacobson, B, Oh, S, Viñolas, X, Rosenqvist, M, Steffel, J, Angchaisuksiri, P, Oto, A, Parkhomenko, A, Al Mahmeed, W, Hu Kangning Chen, D, Zhao, Y, Zhang, H, Chen, J, Cao, S, Wang, D, Yang, Y, Li, W, Li, H, Yin, Y, Tao, G, Yang, P, Chen, Y, He, S, Wang, Y, Fu, G, Li, X, Wu, T, Cheng, X, Yan, X, Zhao, R, Chen, M, Xiong, L, Chen, P, Jiao, Y, Guo, Y, Xue, L, Yang, Z, Jadhavm Raghava Sarma, P, Kulkarni, G, Chandwani, P, Atulbhai Pothiwala, R, Padinhare Purayil, M, Chawla, K, Annasaheb Kothiwale, V, Raghuraman, B, Madan Vijan, V, Sawhney, J, Bantwal, G, Khan, A, Meena, R, Chopada, M, Abraham, S, Bisne, V, Vijayaraghavan, G, Roy, D, Durgaprasad, R, Ravi Shankar, A, Kumar, S, Jain, D, Bhargava, K, Kumar, V, Madappa Nagamalesh, U, Kumar Rajput, R, Koretsune Seishu Kanamori, Y, Yamamoto, K, Kumagai, K, Katsuda, Y, Yoshida, K, Toyota, F, Mizuno, Y, Misumi, I, Noguchi, H, Ando, S, Suetsugu, T, Minamoto, M, Oda, H, Adachi, S, Chiba, K, Norita, H, Tsuruta, M, Koyanagi, T, Ando, H, Higashi, T, Okada, M, Azakami, S, Komaki, S, Kumeda, K, Murayama, T, Matsumura, J, Oba, Y, Sonoda, R, Goto, K, Minoda, K, Haraguchi, Y, Suefuji, H, Miyagi, H, Kato, H, Nakamura, T, Nandate, H, Zaitsu, R, Fujiura, Y, Yoshimura, A, Numata, H, Ogawa, J, Kamogawa, Y, Murakami, K, Wakasa, Y, Yamasawa, M, Maekawa, H, Abe, S, Kihara, H, Tsunoda, S, Saito, K, Tachibana, H, Oba, I, Kuwahata, T, Higa, S, Gushiken, M, Eto, T, Chibana, H, Fujisawa, K, Shiga, Y, Sumi, H, Nagatomo, T, Atsuchi, Y, Nagoshi, T, Sanno, K, Hoshino, F, Yokota, N, Kameko, M, Tabuchi, T, Ishizawa, M, Ikeda, D, Seto, T, Iwao, T, Ishioka, N, Oshiro, K, Tsuchida, K, Hatori, Y, Takeuchi, M, Takezawa, H, Nagano, S, Iwaki, M, Nakamura, Y, Miyamoto, N, Taguchi, T, Ashida, K, Yoshizawa, N, Agata, J, Matsukawa, S, Arasaki, O, Fukuoka, S, Murakami, H, Mishima, K, Hata, Y, Sakuma, I, Obunai, K, Takamura, I, Akutsu, M, Unoki, T, Go, Y, Ikemura, M, Morii, S, Marusaki, S, Doi, H, Tanaka, M, Kusumoto, T, Kakinoki, S, Ogurusu, C, Murata, K, Shimoyama, M, Nakatsuka, M, Kitami, Y, Oyama, R, Ageta, M, Mita, T, Nagao, K, Mito, T, Minami, J, Abe, M, Fujii, M, Okawa, M, Fujito, T, Taniguchi, T, Ko, T, Kubo, H, Imamaki, M, Akiyama, M, Ueda, T, Odakura, H, Inagaki, M, Katsube, Y, Nakata, A, Tomimoto, S, Shibuya, M, Nakano, M, Ito, K, Matsuta, M, Ishiguro, M, Minagawa, T, Wada, M, Mukawa, H, Mizuguchi, M, Okuda, F, Kimura, T, Taga, K, Techigawara, M, Igarashi, M, Watanabe, H, Seo, T, Hiramitsu, S, Hosokawa, H, Hoshiai, M, Hibino, M, Miyagawa, K, Horie, H, Sugishita, N, Soma, A, Neya, K, Yoshida, T, Akahane, K, Takanaka, C, Matsui, S, Kanda, H, Kaneko, M, Nagasaka, S, Taguchi, A, Toru, S, Miyashita, A, Sasaguri, H, Nariyama, J, Hatsuno, T, Iwase, T, Sato, K, Kawai, K, Kotani, T, Tsuji, T, Sakai, H, Nishino, K, Ikeda, K, Maeda, K, Shinozuka, T, Inoue, T, Kawakami, K, Kitazumi, H, Takagi, T, Hamaoka, M, Kojima, J, Sasaki, A, Tsuchiya, Y, Betsuyaku, T, Higuchi, K, Honda, M, Hasegawa, K, Baba, T, Mineoi, K, Koeda, T, Hirasawa, K, Kumazaki, T, Nakagomi, A, Otaki, E, Shindo, T, Hirayama, H, Sugimoto, C, Yamagishi, T, Mizuguchi, I, Sezaki, K, Niwa, I, Takenaka, K, Iiji, O, Taya, K, Kitazawa, H, Ueda, S, Kakuda, H, Ono, T, Oriso, S, Kamata, J, Nanke, T, Maeda, I, Matsuura, Y, Teragawa, H, Maruyama, Y, Takei, K, Kito, T, Asano, H, Matsushita, K, Nakamura, M, Washizuka, T, Sawano, M, Arima, S, Arai, H, Shinohara, H, Takai, H, Furukawa, N, Ota, A, Aoki, K, Yamamoto, T, Kasai, T, Suzuki, S, Shibata, N, Watanabe, M, Nishihata, Y, Arino, T, Okuyama, M, Wakiyama, T, Kato, T, Sasagawa, Y, Tana, T, Hayashi, Y, Hirota, S, Abe, Y, Saito, Y, Uchiyama, H, Takeda, H, Ono, H, Tohyo, S, Hanazono, N, Miyajima, S, Shimono, H, Aoyama, T, Shozawa, Y, Niijima, Y, Murai, O, Inaba, H, Nomura, K, Nozoe, M, Suzuki, K, Furukawa, T, Shiraiwa, T, Ito, N, Nagai, S, Nakahara, S, Shimoyama, Y, Ohara, N, Kozuka, T, Okita, H, Endo, M, Goto, T, Hirose, M, Nagata, E, Nakanishi, N, Mori, T, Seki, S, Okamoto, K, Moriai, O, Emura, Y, Fukuda, T, Date, H, Kawakami, S, Ueyama, Y, Fudo, T, Imaizumi, M, Ogawa, T, Take, S, Ikeda, H, Nishioka, H, Sakamoto, N, Ikeoka, K, Wakaki, N, Doiuchi, J, Kira, T, Tada, M, Tsuzaki, K, Miura, N, Fujisawa, Y, Furumoto, W, Fujisawa, A, Nakamura, R, Komatsu, H, Fujiki, R, Kawano, S, Nishizawa, K, Kato, Y, Azuma, J, Yasui, K, Amano, T, Sekine, Y, Honzawa, T, Koshibu, Y, Sakamoto, Y, Seta, Y, Miyaguchi, S, Morishita, K, Samejima, Y, Sasaki, T, Iseki, F, Kobayashi, T, Kano, H, Kim, J, Yamaguchi, H, Takagi, Y, Onuki Pearce, Y, Suzuki, Y, Fukui, T, Nakayama, T, Kanai, H, Kawano, Y, Ino, T, Miyoshi, H, Miyamoto, Y, Shigekiyo, M, Ono, S, Okamoto, Y, Ubukata, S, Kodera, K, Oriuchi, T, Matsumoto, N, Inagaki, K, Iseki, A, Goda, T, Katsuki, T, Sato, A, Mori, E, Tsubokura, T, Shudo, H, Fujimoto, S, Katsuya, T, Furukawa, Y, Narumi, J, Owari, M, Inakura, T, Anno, T, Shirakawa, K, Keong Ching Toon Wei Lim, C, Foo, D, Wong, K, Yuyang, T, Oh Hui Nam Park, S, Kim, W, Lee, H, Jang, S, Hyeok Kim, D, Ryu, D, Shim, J, Kim, D, Ju Choi, D, Seog Oh, Y, Cho, M, Kim, H, Jeon, H, Shin, D, Weon Park, S, Ki Park, H, Han, S, Hoon Sung, J, Park, H, Nam, G, Keun On, Y, Euy Lim, H, Kwak, J, Cha, T, Jong Hong, T, Hoon Park, S, Han Yoon, J, Kim, N, Kim, K, Chun Jung, B, Hwang, G, Kim, C, Rungaramsin Peerapat Katekangplu, S, Khunrong, P, Bunyapipat, T, Wongcharoen, W, Kaewsuwanna, P, Siriwattana, K, Tiyanon, W, Pattanaprichakul, S, Likittanasombat, K, Cholsaringkarl, D, Boonyapisit, W, Cheewatanakornkul, S, Silaruks, S, Hutayanon, P, Chawanadelert, S, Chattranukulchai, P, Chatlaong, B, Santanakorn, Y, Kanokphatcharakun, K, Mongkolwongroj, P, Jai-Aue, S, Komson, O, Altun Ali Aydinlar, A, Topsakal, R, Ongen, Z, Acikel, S, Yildiray Sahin, D, Yilmaz, O, Birhan Yilmaz, M, Pekdemir, H, Demir, M, Sucu, M, Sahiner, L, Ersanli, M, Okuyan, E, Aras, D, Rolandi Adrian Cesar Ingaramo, F, Alberto Sambadaro, G, Fernandez Caputi, V, Luciardi, H, Graciela Berman, S, Dragotto, P, Javier Kleiban, A, Centurion, N, Andres Ahuad Guerrero, R, Adalberto Di Paola, L, Dario Dran, R, Egido, J, Jose Fosco, M, Alfredo Sinisi, V, Rodolfo Cartasegna, L, Gomez Vilamajo, O, Luis Ramos, J, Sassone, S, Zapata, G, Conde, D, Giacomi, G, Alfredo Fernandez, A, Alberto Berli, M, Ferroni, F, Celestino Sobral Filho Jefferson Jaber, D, Vidal Armaganijan, L, Roberto Frack Costantini, C, Steffens, A, Kunz Sebba Barroso de Souzaem, W, David de Souza Neto, J, Márcio Ribeiro, J, Silveira Teixeira, M, Rossi, P, Pires, L, Moreira, D, Carlos Moura Jorge, J, Menezes Lorga Filho, A, Bodanese, L, Westerlund Montera, M, Henrique Del Carlo, C, Abdalla Saad, J, Augusto Alves da Costa, F, Lopes, R, Roberto de Araújo, G, Roberto Manenti, E, Francisco Kerr Saraiva, J, Carlos Ferreira Braga, J, Negri, A, Moncada, C, Precoma, D, Roquette, F, Reis, G, Álvaro Ramos Filho, R, Lanna Figueiredo, E, Vieira Botelho, R, Munhoz da Fontoura Tavares, C, Carlos Finimundi, H, Kochi, A, Cássio Broilo França, C, Alban, F, Bernardo Aranha Rosito, G, Batista de Moura Xavier Moraes Junior, J, Tadeu Tumelero, R, Maia, L, Simões de Almeida, R, Carter do Carmo Borges, N, Gustavo Gomes Ferreira, L, Corbalán Benjamin Aleck Joseh Stockins Fernandez, R, Montecinos, H, Lanas, F, Larico Gómez, M, Astudillo, C, Conejeros, C, Marin Cuevas, P, Forero, A, Bugueño Gutiérrez, C, Aguilar, J, Potthoff Cardenas, S, Eggers, G, Houzvic, C, Rey, C, Arriagada, G, Charme Vilches, G, Jerjes Sanchez Diaz Jesus Jaime Illescas Diaz, C, Leal Cantu, R, Guadalupe Ramos Zavala, M, Cabrera Jardines, R, Espinola Zavaleta, N, Lopez Rosas, E, Antonio Llamas Esperón, G, Pozas, G, Cardona Muñoz, E, Matadamas Hernandez, N, Leyva Rendon, A, Garcia Hernandez, N, de los Rios Ibarra, M, Ramon Virgen Carrillo, L, Lopez Villezca, D, Hernandez Herrera, C, Jose Lopez Prieto, J, Gaona Rodriguez, R, Villeda Espinosa, E, Flores Martinez, D, Velasco Barcena, J, Fierro Fierro, O, Rodriguez Briones, I, Luis Leiva Pons, J, Alvarez Lopez, H, Olvera Ruiz, R, Gerardo Cantu Brito, C, Julian Jose Roberto Chuquiure Valenzuela, E, Reyes Sanchez, R, Esteban Bazzoni Ruiz, A, Martin Lopez Ruiz, O, Arriaga Nava, R, David Morales Cerda, J, Fajardo Campos, P, Benavides Gonzalez, M, Brodmann Kurt Lenz, M, Hagn, C, Foechterle, J, Drexel, H, Huber, K, Podczeck-Schweighofer, A, Winkler, M, Schneeweiss, B, Gegenhuber, A, Lang, W, Eichinger-Hasenauer, S, Kaserer, P, Sykora, J, Rasch, H, Strohmer, B, Capiau Geert Vervoort, L, Wollaert, B, Hollanders, G, Vercammen, J, Faes, D, Balthazar, Y, Delforge, M, Xhaet, O, Striekwold, H, Thoeng, J, Hermans, K, Mairesse, G, Anné, W, Blankoff, I, Beutels, M, Verstraete, S, Vandergoten, P, Purnode, P, Godart, P, Boussy, T, Desfontaines, P, Heyse, A, Voet, J, De Wolf, A, Zidkova Petr Jansky, E, Spacek, R, Machova, V, Ludka, O, Olsr, J, Kotik, L, Racz, B, Ferkl, R, Hubac, J, Kotik, I, Monhart, Z, Burianova, H, Jerabek, O, Pisova, J, Petrova, I, Dedek, V, Honkova, M, Podrazil, P, Reichert, P, Spinar, J, Novak, M, Durdil, V, Plocova, K, Lastuvka, J, Nielsen Steen Husted, J, Dominguez, H, Hintze, U, Rasmussen, S, Sygehus, N, Bremmelgaard, A, Markenvard, J, Børger, J, Solgaard, J, Eriksen, E, Løkkegaard, T, Bruun, M, Mertz, J, Schou, M, Olsen, M, Raatikainen Carmela Viitanen, P, Paganelli Joël Ohayon, F, Casassus, F, Galinier, M, Gottwalles, Y, Loiselet, P, Muller, J, Bassel Koujan, M, Marquand, A, Destrac, S, Piot, O, Delarche, N, Cebron, J, Guenoun, M, Guedj-Meynier, D, Lokesh, A, Zuber, M, Amarenco, P, Ellie, E, Kadouch, J, Fournier, P, Huberman, J, Lemaire, N, Rodier, G, Vandamme, X, Sibon, I, Neau, J, Hélène Mahagne, M, Mielot, A, Bonnefoy, M, Churet, J, Navarre, V, Sellem, F, Monniot, G, Boyes, J, Doucet, B, Martelet, M, Obadia, D, Crousillat, B, Mouallem, J, Bearez, E, Philippe Brugnaux, J, Fedorowsky, A, Nazeyrollas, P, Berneau, J, Chemin, F, Schellong Harald Darius, S, Koeniger, G, Kopf, A, Gerbaulet, U, Kellner, B, Schaefer, T, Purr, J, Eißfeller, E, Zauzig, H, Riegel, P, Axthelm, C, Heinz, G, Menke, H, Pustelnik, A, Zutz, S, Eder, W, Rehling, G, Glatzel, D, Ludwig, N, Sandow, P, Wiswedel, H, Wildenauer, C, Schoen, S, Schwarz, T, Babyesiza, A, Kropp, M, Zimny, H, Kahl, F, Caspar, A, Omankowsky, S, Laessig, T, Hartmann, H, Lehmann, G, Bindig, H, Hergdt, G, Reimer, D, Hauk, J, Michel, H, Werner Erdle, P, Dorsch, W, Dshabrailov, J, Rapp, K, Vormann, R, Mueller, T, Mayer, P, Horstmeier, U, Eissing, V, Hey, H, Leuchtgens, H, Lilienweiss, V, Mueller, H, Schubert, C, Lauer, H, Buchner, T, Brauer, G, Kamin, S, Mueller, K, Baumbach, S, Abdel-Qader, M, Ebert, H, Schwencke, C, Bernhardt, P, Karolyi, L, Sievers, B, Haverkamp, W, Roehnisch, J, Vertes Gabor Szantai, A, Matoltsy, A, Kanakaridisz, N, Boda, Z, Kis, E, Gaszner, B, Juhasz, F, Juhasz, G, Kancz, S, Laszlo, Z, May, Z, Merkely, B, Noori, E, Habon, T, Polgar, P, Szalai, G, Vangel, S, Nagy, A, Engelthaler, G, Ferenczi, J, Egyutt, M, Martini Leone Maria Cristina, G, Tiraferri, E, Santoro, R, Testa, S, Di Minno, G, Moia, M, Maria Caimi, T, Tessitori, M, Cappelli, R, Poli, D, Quintavalla, R, Cosmi, F, Fanelli, R, Oriana, V, Reggio, R, Santi, R, Pancaldi, L, De Cristofaro, R, Guazzaloca, G, De Blasio, A, Salerno Uriate, J, Lillo, F, Maria Pogliani, E, Bilo, G, Accogli, M, Mariani, A, Feola, M, Raisaro, A, Fattore, L, Mauric, A, Germini, F, Tedeschi, L, Settimi, M, Nicoli, S, Ricciarini, P, Argena, A, Ronchini, P, Bulla, C, Tradati, F, Volpe, M, D’Avino, M, Grazia Bongiorni, M, Severi, S, Capucci, A, Lodigiani, C, Salomone, E, Serviddio, G, Tondo, C, Golino, P, Mazzone, C, Iacopino, S, Ruiter, H, Lucassen, A, Adriaansen, H, Bongaerts, M, Pieterse, M, van Guldener, C, Herrman, J, Nierop, S, Hoogslag, P, Hermans, W, Groenemeijer, B, Terpstra, W, Buiks, C, Boersma, L, Berge Per Anton Sirnes, E, Gjertsen, E, Hole, T, Erga, K, Hallaråker, A, Skjelvan, G, Østrem, A, Ghezai, B, Svilaas, A, Christersson, P, Øien, T, Høegh Henrichsen, S, Erik Otterstad, J, Berg-Johansen, J, Stepinska Andrzej Gieroba, J, Biedrzycka, M, Ogorek, M, Wozakowska-Kaplon, B, Loboz-Grudzien, K, Jaroslaw, Supinski, W, Kuzniar, J, Zaluska, R, Hiczkiewicz, J, Swiatkowska-Byczynska, L, Kucharski, L, Gruchala, M, Minc, P, Olszewski, M, Kania, G, Krzciuk, M, Lajkowski, Z, Ostrowska-Pomian, B, Lewczuk, J, Zinka, E, Karczmarczyk, A, Chmielnicka-Pruszczynska, M, Wozniak-Skowerska, I, Opolski, G, Bronisz, M, Glanowska, G, Ruszkowski, P, Skonieczny, G, Sciborski, R, Okopien, B, Kukla, P, Galbas, K, Cymerman, K, Jurowiecki, J, Miekus, P, Myszka, W, Mazur, S, Lysek, R, Baszak, J, Rusicka-Piekarz, T, Raczak, G, Domanska, E, Nessler, J, Lesnik, J, Eltishcheva Roman Libis, V, Kamalov, G, Belenky, D, Egorova, L, Khokhlov, A, Yakupov, E, Zateyshchikov, D, Barbarash, O, Miller, O, Mazur, E, Zrazhevskiy, K, Novikova, T, Moiseeva, Y, Polkanova, E, Sobolev, K, Rossovskaya, M, Shapovalova, Y, Kolesnikova, A, Nikolaev, K, Zemlianskaia, O, Zateyshchikova, A, Kostenko, V, Popov, S, Poltavskaya, M, Edin, A, Aleksandrova Oksana Drapkina, E, Vishnevsky, A, Nagibovich, O, Chizhov, P, Rachkova, S, Sergeev, M, Kurylo, B, Ushakov, A, Vinolas Pere Alvarez Garcia, X, Fernanda Lopez Fernandez, M, Tercedor Sanchez, L, Tranche Iparraguirre, S, Toran Monserrat, P, Marquez Contreras, E, Isart Rafecas, J, Motero Carrasco, J, Garcia Pavia, P, Gomez Pajuelo, C, Miguel Rincon Diaz, L, Fernando Iglesias Alonso, L, Grande Ruiz, A, Merce Klein, J, Ramon Gonzalez Juanatey, J, Monte Collado, I, Palacin Piquero, H, Brotons Cuixart, C, Fernandez Escobar, E, i Llibre, J, Corros Vicente, C, Vida Gutierrez, M, Epelde Gonzalo, F, Alexandre Almeida Fernandez, C, Martinez Navarro, E, Jose Montero Alia, J, Barreda Gonzalez, M, Angels Moleiro Oliva, M, Iglesias Sanmartin, J, Jimenez Gonzalez, M, del Mar Rodriguez Alvarez, M, Herreros Melenchon, J, Ripoll Vera, T, Jimenez Navarro, M, Vazquez Caamano, M, Fe Arcocha Torres, M, Marcos Gomez, G, Iniguez Romo, A, Angel Prieto Diaz, M, Rosenqvist Alexander Wirdby, M, Centrumkliniken, Lindén, J, Henriksson, K, Elmersson, M, Egilsson, A, Börjesson, U, Svärd, G, Liu, B, Lindh, A, Olsson, L, Gustavsson, M, Andersson, L, Benson, L, Bothin, C, Hajimirsadeghi, A, Martinsson, B, Ericsson, M, Ohlsson, Å, Lindvall, H, Svensson, P, Thörne, K, Händel, H, Platonov, P, Bernsten, F, Timberg, I, Crisby, M, Karlsson, J, Andersson, A, Malmqvist, L, Engdahl, J, Thulin, J, Hot-Bjelak, A, Jensen, S, Stalby, P, Steffel Johann Debrunner, J, Beer, J, Shah, D, Rudyk Vira Tseluyko, I, Karpenko, O, Zhurba, S, Kraiz, I, Parkhomenko, O, Kupnovytska, I, Seredyuk, N, Mostovoy, Y, Ushakov, O, Koval, O, Kovalskiy, I, Svyshchenko, Y, Sychov, O, Stanislavchuk, M, Yagensky, A, Tykhonova, S, Fushtey, I, Murdoch Naresh Chauhan, W, Goodwin, D, Lumley, L, Patel, R, Saunders, P, Wong, B, Cameron, A, Patel, N, Jhittay, P, Ross, A, Kainth, M, Ladha, K, Douglas, K, Pickavance, G, Mcdonnell, J, Handscombe, L, Gooding, T, Wagner, H, Cumberlidge, Bradshaw, C, Bromham, C, Jones, K, Suryani, S, Coates, R, Sarai, B, Willcock, W, Sircar, S, Cairns, J, Gilliand, A, Bilas, R, Strieder, E, Hutchinson, P, Wakeman, A, Stokes, M, Kirby, G, Vishwanathan, B, Bird, N, Evans, P, Clark, M, Bisatt, J, Litchfield, J, Fisher, E, Fooks, T, Kelsall, R, Paul, N, Alborough, E, Aziz, M, Ramesh, C, Wilson, P, Franklin, S, Fairhead, S, Thompson, J, Chowan, H, Taylor, G, Tragen, D, Parfitt, M, Seamark, C, Paul, C, Richardson, M, Jefferies, A, Sharp, H, Jones, H, Giles, C, Bramley, M, Williams, P, Aldegather, J, Wetherell, S, Lumb, W, Scouller, F, Macey, N, Rogers, S, Stipp, Y, West, R, Pinney, P, Wadeson, P, Matthews, J, Pandya, P, Gallagher, A, Railton, T, Davies, E, Mcclure, J, Jacobs, M, Hutton, C, Thompson, R, Sinha, B, Butter, K, Barrow, S, Little, H, Russell, D, Choudhary, U, Haq, I, Ainsworth, P, Jones, C, Weeks, P, Eden, J, Gibbons, L, Glencross, J, Macleod, A, Poland, K, Mulolland, C, Warke, A, Conn, P, Burns, D, Smith, R, Kamath, R, Webster, J, Hodgins, I, Vercoe, S, Roome, P, Pinnock, H, Patel, J, Ali, A, Hart, N, Davies, R, De-Sousa, N, Neden, C, Danielsen, M, Sharma, P, Galloway, S, Hawkins, C, Oliver, R, Aylward, M, Pattni, M, Irvine, G, Ahmad, S, Rothwell, C, Choudhary, F, Khalaque, S, Short, S, Peters, S, Coulson, W, Roberts, N, Butler Steven Coates, A, Ward, B, Jackson, D, Walton, S, Shepherd, D, Wong, T, Boon, M, Deacon, M, Cornelius, D, Davies, S, Frankel, B, Hargreaves, N, Choi, H, Sumner, J, Myhill, T, Estifanos, S, Geatch, D, Wilkinson, J, Veale, R, Forshaw, K, Hirst, R, Zaman, K, Liley, C, Wastling, R, Mceleny, P, Beattie, A, Cooke, P, Wong, M, Pugsley, M, Dooldeniya, C, Rogers, G, Bennett, J, Jacobs, P, Muvva, R, Adam, M, Fox, R, Thomas, N, Cartwright, S, Reed, R, Randfield, S, A’Court, C, Flynn, A, Halpin, A, Dobson, S, Lomax, L, Nadaph, M, Munro, I, Goram, J, Stoddart, H, Simmons, P, Shewring, J, Bowen-Simpkins, E, Rickenbach, M, Blenkhorn Bhuwanendu Singh, A, Astridge, P, van Gaal, W, Abhayaratna, W, Thomson, P, Lehman, R, Kilian, J, Coulshed, D, Catanchin, A, Colquhoun, D, Kiat, H, Eccleston, D, French, J, Ayres, B, Blombery, P, Phan, T, Rogers, J, O’Donnell, D, Cheol Bae, S, Gibbs, H, Carroll, P, Starmer, G, Arstall, M, Binnekamp, M, Lee, A, Eikelboom Robert Luton, J, Gupta, M, Shekhar Pandey, A, Cheung, S, Leader, R, Beaudry, P, Ayala-Paredes, F, Berlingieri, J, Heath, J, Poirier, G, du Preez, M, Schweitzer, B, Nadeau, R, Dhillon, R, Hruczkowski, T, Lavoie, A, Parkash, R, Cha, J, Coutu, B, Macdonald, P, Ramjattan, B, Bonet, J, Vizel, S, Angaran, P, Fikry, S, Mowafy Azza Katta, A, Tawfik, M, Nawar, M, Sobhy, M, Kamal Abou Seif, S, Khairy, T, Abd El-Aziz, A, Taha, N, Reda, A, Elbahry, A, Setiha, M, Gamal El Din, M, Elkhadem, M, El-Etreby, A, Kettles Junaid Bayat, D, Siebert, H, Horak, A, Kelfkens, Y, Garda, R, Pillay, T, Guerra, M, van Zyl, L, Theron, H, Murray, A, Louw, R, Greyling, D, Mntla, P, Ismail, S, Ahmed, F, Engelbrecht, J, Maharajh, S, Oosthuysen, W, Loghdey, R, Ueckermann, V, AlAl Mahmeed AbdullahNaeemi, W, Yousef, G, Bazargani, N, Alomairi, M, Maruthanayagam, R, Singh, R, Naguib, A, Ibrahim, M, Agrawal, A, Nathani, M, Esheiba, E, Wassef, A, Gupta, R, Cox Scott Beach, M, Duffy, P, Falkowski, S, Ferrick, K, Franco, M, Michael Kutayli, W, Quick, A, Sharma, N, Wilson, V, Miller, S, Alberts, M, Blumberg, E, Canosa, R, Gutowski, T, Ison, R, Garcia, J, Mullen, P, Noveck, H, Rama, P, Reddy, R, Williams, M, Nishijima, D, Ferdinand, K, Haque, I, Mendelson, R, Pitta, S, Theodoro, D, Treasure, C, Moustafa, M, Cader, C, Pharr, W, Oropallo, A, Platt, G, Gujral, J, Welker, J, Koura, F, Haas, Sylvia, Camm, John A, Harald, Darius, Steffel, Jan, Virdone, Saverio, Pieper, Karen, Brodmann, Marianne, Schellong, Sebastian, Misselwitz, Frank, Kayani, Gloria, Ajay K. Kakkar, Jean-Pierre Bassand, A. John Camm, David A. Fitzmaurice, Keith A. A. Fox, Bernard J. Gersh, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Karen S. Pieper, Alexander G. G. Turpie, Martin van Eickels, Freek W. A. Verheugt, Keith A. A. Fox Bernard J. Gersh, Hector Lucas Luciardi Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, John Eikelboom, Ramon Corbalan, Zhi-Cheng Jing, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, Dayi Hu Kangning Chen, Yusheng Zhao, Huaiqin Zhang, Jiyan Chen, Shiping Cao, Daowen Wang, Yuejin Yang, Weihua Li, Hui Li, Yuehui Yin, Guizhou Tao, Ping Yang, Yingmin Chen, Shenghu He, Yong Wang, Guosheng Fu, Xin Li, Tongguo Wu, Xiaoshu Cheng, Xiaowei Yan, Ruiping Zhao, Moshui Chen, Longgen Xiong, Ping Chen, Yang Jiao, Ying Guo, Li Xue, Zhiming Yang, Praveen Jadhavm Raghava Sarma, Govind Kulkarni, Prakash Chandwani, Rasesh Atulbhai Pothiwala, Mohanan Padinhare Purayil, Kamaldeep Chawla, Veerappa Annasaheb Kothiwale, Bagirath Raghuraman, Vinod Madan Vijan, Jitendra Sawhney, Ganapathi Bantwal, Aziz Khan, Ramdhan Meena, Manojkumar Chopada, Sunitha Abraham, Vikas Bisne, Govindan Vijayaraghavan, Debabrata Roy, Rajashekhar Durgaprasad, A. G. Ravi Shankar, Sunil Kumar, Dinesh Jain, Kartikeya Bhargava, Vinay Kumar, Udigala Madappa Nagamalesh, Rajeeve Kumar Rajput, Yukihiro Koretsune Seishu Kanamori, Kenichi Yamamoto, Koichiro Kumagai, Yosuke Katsuda, Keiki Yoshida, Fumitoshi Toyota, Yuji Mizuno, Ikuo Misumi, Hiroo Noguchi, Shinichi Ando, Tetsuro Suetsugu, Masahiro Minamoto, Hiroyuki Oda, Susumu Adachi, Kei Chiba, Hiroaki Norita, Makoto Tsuruta, Takeshi Koyanagi, Kunihiko Yamamoto, Hiroshi Ando, Takayuki Higashi, Megumi Okada, Shiro Azakami, Shinichiro Komaki, Kenshi Kumeda, Takashi Murayama, Jun Matsumura, Yurika Oba, Ryuji Sonoda, Kazuo Goto, Kotaro Minoda, Yoshikuni Haraguchi, Hisakazu Suefuji, Hiroo Miyagi, Hitoshi Kato, Tsugihiro Nakamura, Tadashi Nakamura, Hidekazu Nandate, Ryuji Zaitsu, Yoshihisa Fujiura, Akira Yoshimura, Hiroyuki Numata, Jun Ogawa, Yasuyuki Kamogawa, Kinshiro Murakami, Yutaka Wakasa, Masanori Yamasawa, Hiromitsu Maekawa, Sumihisa Abe, Hajime Kihara, Satoru Tsunoda, Katsumi Saito, Hiroki Tachibana, Ichiro Oba, Takashi Kuwahata, Satoshi Higa, Masamichi Gushiken, Takuma Eto, Hidetoshi Chibana, Kazuaki Fujisawa, Yuhei Shiga, Hirokuni Sumi, Toshihisa Nagatomo, Yoshihiko Atsuchi, Toshiro Nagoshi, Kazuhisa Sanno, Fumihiro Hoshino, Naoto Yokota, Masahiro Kameko, Toshifumi Tabuchi, Munesumi Ishizawa, Yoshitake Fujiura, Daisuke Ikeda, Taku Seto, Tetsu Iwao, Norio Ishioka, Koichi Oshiro, Keizo Tsuchida, Yutaka Hatori, Motoshi Takeuchi, Hiroto Takezawa, Shinjiro Nagano, Masaaki Iwaki, Yuichiro Nakamura, Naomasa Miyamoto, Toshifumi Taguchi, Ko Ashida, Naoto Yoshizawa, Jun Agata, Seishiro Matsukawa, Osamu Arasaki, Shuji Fukuoka, Hirofumi Murakami, Kazuya Mishima, Yoshiki Hata, Ichiro Sakuma, Kotaro Obunai, Ichiro Takamura, Mitsuyuki Akutsu, Toshihide Unoki, Yoshinori Go, Makoto Ikemura, Shoji Morii, Shigeru Marusaki, Hideo Doi, Mitsuru Tanaka, Takaaki Kusumoto, Shigeo Kakinoki, Chiga Ogurusu, Kazuya Murata, Masaki Shimoyama, Masami Nakatsuka, Yutaka Kitami, Yoichi Nakamura, Hiroshi Oda, Rikimaru Oyama, Masato Ageta, Teruaki Mita, Kazuhiko Nagao, Takafumi Mito, Junichi Minami, Mitsunori Abe, Masako Fujii, Makoto Okawa, Tsuneo Fujito, Toshiya Taniguchi, Tenei Ko, Hiroshi Kubo, Mizuho Imamaki, Masahiro Akiyama, Takashi Ueda, Hironori Odakura, Masahiko Inagaki, Yoshiki Katsube, Atsuyuki Nakata, Shinobu Tomimoto, Mitsuhiro Shibuya, Masayuki Nakano, Kenichiro Ito, Masahiro Matsuta, Motoyuki Ishiguro, Taro Minagawa, Masamichi Wada, Hiroaki Mukawa, Masato Mizuguchi, Fumio Okuda, Teruaki Kimura, Kuniaki Taga, Masaaki Techigawara, Morio Igarashi, Hiroshi Watanabe, Toshihiko Seo, Shinya Hiramitsu, Hiroaki Hosokawa, Mitsumoto Hoshiai, Michitaka Hibino, Koichi Miyagawa, Hideki Horie, Nobuyoshi Sugishita, Yukio Shiga, Akira Soma, Kazuo Neya, Tetsuro Yoshida, Kunio Akahane, Sen Adachi, Chiei Takanaka, Saori Matsui, Hirofumi Kanda, Masanori Kaneko, Shiro Nagasaka, Atsushi Taguchi, Shuta Toru, Kazuyuki Saito, Akiko Miyashita, Hiroki Sasaguri, Jin Nariyama, Taketo Hatsuno, Takash Iwase, Kazuki Sato, Kazuya Kawai, Tomobumi Kotani, Tsuyoshi Tsuji, Hirosumi Sakai, Kiyoshi Nishino, Kenichi Ikeda, Kazuo Maeda, Tomohiro Shinozuka, Takeshi Inoue, Koichi Kawakami, Hiromichi Kitazumi, Tsutomu Takagi, Mamoru Hamaoka, Jisho Kojima, Akitoshi Sasaki, Yoshihiro Tsuchiya, Tetsuo Betsuyaku, Koji Higuchi, Masaaki Honda, Koichi Hasegawa, Takao Baba, Kazuaki Mineoi, Toshihiko Koeda, Kunihiko Hirasawa, Toshihide Kumazaki, Akira Nakagomi, Eiji Otaki, Takashi Shindo, Hiroyoshi Hirayama, Chikako Sugimoto, Takashi Yamagishi, Ichiro Mizuguchi, Kazunori Sezaki, Isamu Niwa, Ken Takenaka, Osamu Iiji, Koichi Taya, Hitoshi Kitazawa, samu Ueda, Hirokazu Kakuda, Takuya Ono, Seizo Oriso, Junya Kamata, Toshihiko Nanke, Itaru Maeda, Yoshifusa Matsuura, Hiroki Teragawa, Yasuyuki Maruyama, Kazuo Takei, Hajime Horie, Tetsutaro Kito, Hiroshi Asano, Koji Matsushita, Masaichi Nakamura, Takashi Washizuka, Tomoki Yoshida, Masato Sawano, Shinichi Arima, Hidekazu Arai, Hisanori Shinohara, Hiroyuki Takai, Nobufusa Furukawa, Akira Ota, Kentaro Yamamoto, Kenji Aoki, Taku Yamamoto, Takeaki Kasai, Shunji Suzuki, Shu Suzuki, Nitaro Shibata, Masayuki Watanabe, Yosuke Nishihata, Toru Arino, Masaki Okuyama, Tetsushi Wakiyama, Tomoko Kato, Yasuo Sasagawa, Takeshi Tana, Yoshihito Hayashi, Shinichi Hirota, Yukihiko Abe, Yoshihiro Saito, Hirohide Uchiyama, Hiroshi Takeda, Hiroshi Ono, Shuichi Tohyo, Naoto Hanazono, Seiichi Miyajima, Hisashi Shimono, Takuma Aoyama, Yasunobu Shozawa, Yawara Niijima, Osamu Murai, Hideko Inaba, Katsumasa Nomura, Masatsugu Nozoe, Kazuo Suzuki, Toshiyuki Furukawa, Toshihiko Shiraiwa, Nobuhisa Ito, Shunichi Nagai, Kiyoharu Sato, Shiro Nakahara, Yujin Shimoyama, Naoko Ohara, Teruhiko Kozuka, Hideaki Okita, Masato Endo, Tsutomu Goto, Makoto Hirose, Emiko Nagata, Noriyuki Nakanishi, Toshizumi Mori, Shuichi Seki, Katsuhiro Okamoto, Osamu Moriai, Yoko Emura, Tsuyoshi Fukuda, Haruhiko Date, Shuichi Kawakami, Sho Nagai, Yuya Ueyama, Tetsuro Fudo, Mitsuru Imaizumi, Takuo Ogawa, Shunsuke Take, Hideo Ikeda, Hiroaki Nishioka, Norihiko Sakamoto, Kiyomitsu Ikeoka, Nobuo Wakaki, Masatake Abe, Junji Doiuchi, Tetsuya Kira, Masato Tada, Ken Tsuzaki, Naoya Miura, Yasuaki Fujisawa, Wataru Furumoto, Susumu Suzuki, Akinori Fujisawa, Ryosai Nakamura, Hiroyasu Komatsu, Rei Fujiki, Shuichi Kawano, Keijiro Nishizawa, Yoji Kato, Junya Azuma, Kiyoshi Yasui, Toshio Amano, Yasuhiro Sekine, Tatsuo Honzawa, Yuichiro Koshibu, Yasuhide Sakamoto, Yukihiro Seta, Shingo Miyaguchi, Kojuro Morishita, Yasuko Samejima, Toyoshi Sasaki, Fumiko Iseki, Toshiyuki Kobayashi, Hiroshi Kano, Jaeyoung Kim, Hiroshi Yamaguchi, Yoichi Takagi, Yoko Onuki Pearce, Yasuyuki Suzuki, Takayuki Fukui, Toru Nakayama, Hideaki Kanai, Yoshiyuki Kawano, Tetsuji Ino, Hironori Miyoshi, Yasufumi Miyamoto, Masahito Shigekiyo, Shimato Ono, Yutaka Okamoto, Satoshi Ubukata, Kojiro Kodera, Tatsuo Oriuchi, Naoki Matsumoto, Koichi Inagaki, Atsushi Iseki, Tomohiro Yoshida, Toshihiro Goda, Tsukasa Katsuki, Atsushi Sato, Etsuo Mori, Toshio Tsubokura, Hiroshi Shudo, Shunichi Fujimoto, Tomohiro Katsuya, Yoshiyuki Furukawa, Hiroshi Hosokawa, Jun Narumi, Kiichiro Yamamoto, Masaki Owari, Takuya Inakura, Takafumi Anno, Kazuyuki Shirakawa, Chi Keong Ching Toon Wei Lim, David Foo, Kelvin Wong, Tan Yuyang, Seil Oh Hui Nam Park, Woo-Shik Kim, HyeYoung Lee, Sung-Won Jang, Dae Hyeok Kim, Jun Kim, DongRyeol Ryu, Jaemin Shim, Dae-Kyeong Kim, Dong Ju Choi, Yong Seog Oh, Myeong-Chan Cho, Hack-Lyoung Kim, Hui-Kyung Jeon, Dong-Gu Shin, Sang Weon Park, Hoon Ki Park, Sang-Jin Han, Jung Hoon Sung, Hyung-Wook Park, Gi-Byoung Nam, Young Keun On, Hong Euy Lim, JaeJin Kwak, Tae-Joon Cha, Taek Jong Hong, Seong Hoon Park, Jung Han Yoon, Nam-Ho Kim, Kee-Sik Kim, Byung Chun Jung, Gyo-Seung Hwang, Chong-Jin Kim, Sakda Rungaramsin Peerapat Katekangplu, Porames Khunrong, Thanita Bunyapipat, Wanwarang Wongcharoen, Pinij Kaewsuwanna, Khanchai Siriwattana, Waraporn Tiyanon, Supalerk Pattanaprichakul, Khanchit Likittanasombat, Doungrat Cholsaringkarl, Warangkana Boonyapisit, Sirichai Cheewatanakornkul, Songkwan Silaruks, Pisit Hutayanon, Seksan Chawanadelert, Pairoj Chattranukulchai, Boonsert Chatlaong, Yingsak Santanakorn, Khompiya Kanokphatcharakun, Piya Mongkolwongroj, Sasivimon Jai-Aue, Ongkarn Komson, Armagan Altun Ali Aydinlar, Ramazan Topsakal, Zeki Ongen, Sadik Acikel, Durmus Yildiray Sahin, Ozcan Yilmaz, Mehmet Birhan Yilmaz, Hasan Pekdemir, Mesut Demir, Murat Sucu, Levent Sahiner, Murat Ersanli, Ertugrul Okuyan, Dursun Aras, Florencia Rolandi Adrian Cesar Ingaramo, Gustavo Alberto Sambadaro, Vanina Fernandez Caputi, Hector Luciardi, Sofia Graciela Berman, Pablo Dragotto, Andres Javier Kleiban, Nestor Centurion, Rodolfo Andres Ahuad Guerrero, Leonel Adalberto Di Paola, Ricardo Dario Dran, Javier Egido, Matias Jose Fosco, Victor Alfredo Sinisi, Luis Rodolfo Cartasegna, Oscar Gomez Vilamajo, Jose Luis Ramos, Sonia Sassone, Gerardo Zapata, Diego Conde, Guillermo Giacomi, Alberto Alfredo Fernandez, Mario Alberto Berli, Fabian Ferroni, Dário Celestino Sobral Filho Jefferson Jaber, Luciana Vidal Armaganijan, Costantino Roberto Frack Costantini, André Steffens, Weimar Kunz Sebba Barroso de Souzaem, João David de Souza Neto, José Márcio Ribeiro, Marcelo Silveira Teixeira, Paulo Rossi, Leonardo Pires, Daniel Moreira, José Carlos Moura Jorge, Adalberto Menezes Lorga Filho, Luiz Bodanese, Marcelo Westerlund Montera, Carlos Henrique Del Carlo, Jamil Abdalla Saad, Fernando Augusto Alves da Costa, Renato Lopes, Gilson Roberto de Araújo, Euler Roberto Manenti, Jose Francisco Kerr Saraiva, João Carlos Ferreira Braga, Alexandre Negri, Carlos Moncada, Dalton Precoma, Fernando Roquette, Gilmar Reis, Roberto Álvaro Ramos Filho, Estêvão Lanna Figueiredo, Roberto Vieira Botelho, Cláudio Munhoz da Fontoura Tavares, Helius Carlos Finimundi, Adriano Kochi, César Cássio Broilo França, Fábio Alban, Guido Bernardo Aranha Rosito, João Batista de Moura Xavier Moraes Junior, Rogério Tadeu Tumelero, Lilia Maia, Roberto Simões de Almeida, Ney Carter do Carmo Borges, Luís Gustavo Gomes Ferreira, Ramón Corbalán Benjamin Aleck Joseh Stockins Fernandez, Humberto Montecinos, Fernando Lanas, Martín Larico Gómez, Carlos Astudillo, Carlos Conejeros, Patricio Marin Cuevas, Alejandro Forero, Claudio Bugueño Gutiérrez, Juan Aguilar, Sergio Potthoff Cardenas, German Eggers, Cesar Houzvic, Carlos Rey, Germán Arriagada, Gustavo Charme Vilches, Carlos Jerjes Sanchez Diaz Jesus Jaime Illescas Diaz, Raul Leal Cantu, Maria Guadalupe Ramos Zavala, Ricardo Cabrera Jardines, Nilda Espinola Zavaleta, Enrique Lopez Rosas, Guillermo Antonio Llamas Esperón, Gerardo Pozas, Ernesto Cardona Muñoz, Norberto Matadamas Hernandez, Adolfo Leyva Rendon, Norberto Garcia Hernandez, Manuel de los Rios Ibarra, Luis Ramon Virgen Carrillo, David Lopez Villezca, Carlos Hernandez Herrera, Juan Jose Lopez Prieto, Rodolfo Gaona Rodriguez, Efrain Villeda Espinosa, David Flores Martinez, Jose Velasco Barcena, Omar Fierro Fierro, Ignacio Rodriguez Briones, Jose Luis Leiva Pons, Humberto Alvarez Lopez, Rafael Olvera Ruiz, Carlos Gerardo Cantu Brito, Eduardo Julian Jose Roberto Chuquiure Valenzuela, Roxana Reyes Sanchez, Alberto Esteban Bazzoni Ruiz, Oscar Martin Lopez Ruiz, Roberto Arriaga Nava, Jesus David Morales Cerda, Pedro Fajardo Campos, Mario Benavides Gonzalez, Marianne Brodmann Kurt Lenz, Claus Hagn, Johannes Foechterle, Heinz Drexel, Kurt Huber, Andrea Podczeck-Schweighofer, Michael Winkler, Bruno Schneeweiss, Alfons Gegenhuber, Wilfried Lang, Sabine Eichinger-Hasenauer, Peter Kaserer, Josef Sykora, Heribert Rasch, Bernhard Strohmer, Luc Capiau Geert Vervoort, Bart Wollaert, Geert Hollanders, Jan Vercammen, Dirk Faes, Yohan Balthazar, Marc Delforge, Olivier Xhaet, Harry Striekwold, John Thoeng, Kurt Hermans, Georges Mairesse, Wim Anné, Ivan Blankoff, Michel Beutels, Stefan Verstraete, Peter Vandergoten, Philippe Purnode, Pascal Godart, Tim Boussy, Philippe Desfontaines, Alex Heyse, Joeri Voet, Axel De Wolf, Eva Zidkova Petr Jansky, Rudolf Spacek, Vilma Machova, Ondrej Ludka, Josef Olsr, Lubos Kotik, Blazej Racz, Richard Ferkl, Jan Hubac, Ilja Kotik, Zdenek Monhart, Hana Burianova, Ondrej Jerabek, Jana Pisova, Iveta Petrova, Vratislav Dedek, Michaela Honkova, Petr Podrazil, Petr Reichert, Jindrich Spinar, Miroslav Novak, Vaclav Durdil, Katarina Plocova, Jiri Lastuvka, Jørn Nielsen Steen Husted, Helena Dominguez, Ulrik Hintze, Søren Rasmussen, Næstved Sygehus, Arne Bremmelgaard, John Markenvard, Jan Børger, Jorgen Solgaard, Ebbe Eriksen, Thomas Løkkegaard, Michael Bruun, Jacob Mertz, Morten Schou, Michael Olsen, Pekka Raatikainen Carmela Viitanen, Franck Paganelli Joël Ohayon, Frédéric Casassus, Michel Galinier, Yannick Gottwalles, Philippe Loiselet, Jean-Joseph Muller, Mohamed Bassel Koujan, André Marquand, Sylvain Destrac, Olivier Piot, Nicolas Delarche, Jean-Pierre Cebron, Maxime Guenoun, Dominique Guedj-Meynier, A. G. Lokesh, Mathieu Zuber, Pierre Amarenco, Emmanuel Ellie, James Kadouch, Pierre-Yves Fournier, Jean-Pierre Huberman, Nestor Lemaire, Gilles Rodier, Xavier Vandamme, Igor Sibon, Jean-Philippe Neau, Marie Hélène Mahagne, Antoine Mielot, Marc Bonnefoy, Jean-Baptiste Churet, Vincent Navarre, Frederic Sellem, Gilles Monniot, Jean-Paul Boyes, Bernard Doucet, Michel Martelet, Désiré Obadia, Bernard Crousillat, Joseph Mouallem, Etienne Bearez, Jean Philippe Brugnaux, Alain Fedorowsky, Pierre Nazeyrollas, Jean-Baptiste Berneau, Frédéric Chemin, Sebastien Schellong Harald Darius, Georg Koeniger, Andreas Kopf, Uwe Gerbaulet, Bernd-Thomas Kellner, Thomas Schaefer, Jan Purr, Enno Eißfeller, Heinz-Dieter Zauzig, Peter Riegel, Christoph Axthelm, Gerd-Ulrich Heinz, Holger Menke, Andreas Pustelnik, Stefan Zutz, Wolfgang Eder, Guenter Rehling, Dirk Glatzel, Norbert Ludwig, Petra Sandow, Henning Wiswedel, Cosmas Wildenauer, Steffen Schoen, Toralf Schwarz, Adyeri Babyesiza, Maximilian Kropp, Hans-Hermann Zimny, Friedhelm Kahl, Andreas Caspar, Sabine Omankowsky, Torsten Laessig, Hermann-Josef Hartmann, Gunter Lehmann, Hans-Walter Bindig, Gunter Hergdt, Dietrich Reimer, Joachim Hauk, Holger Michel, Praxis Dres. Werner Erdle, Wilfried Dorsch, Janna Dshabrailov, Karl-Albrecht Rapp, Reinhold Vormann, Thomas Mueller, Peter Mayer, Uwe Horstmeier, Volker Eissing, Heinz Hey, Heinz Leuchtgens, Volker Lilienweiss, Heiner Mueller, Christian Schubert, Herrmann Lauer, Thomas Buchner, Gunter Brauer, Susanne Kamin, Karsten Mueller, Sylvia Baumbach, Muwafeg Abdel-Qader, Hans-Holger Ebert, Carsten Schwencke, Peter Bernhardt, Laszlo Karolyi, Britta Sievers, Wilhelm Haverkamp, Jens-Uwe Roehnisch, Andras Vertes Gabor Szantai, Andras Matoltsy, Nikosz Kanakaridisz, Zoltan Boda, Erno Kis, Balazs Gaszner, Ferenc Juhasz, Gizella Juhasz, Sandor Kancz, Zoltan Laszlo, Zsolt May, Bela Merkely, Ebrahim Noori, Tamas Habon, Peter Polgar, Gabriella Szalai, Sandor Vangel, Andras Nagy, Gabriella Engelthaler, Judit Ferenczi, Mihaly Egyutt, Giuliana Martini Leone Maria Cristina, Eros Tiraferri, Rita Santoro, Sophie Testa, Giovanni Di Minno, Marco Moia, Teresa Maria Caimi, Maria Tessitori, Roberto Cappelli, Daniela Poli, Roberto Quintavalla, Franco Cosmi, Raffaele Fanelli, Vincenzo Oriana, Raffaele Reggio, Roberto Santi, Leonardo Pancaldi, Raimondo De Cristofaro, Giuliana Guazzaloca, Angelo De Blasio, Jorge Salerno Uriate, Flavia Lillo, Enrico Maria Pogliani, Grzegorz Bilo, Michele Accogli, Antonio Mariani, Mauro Feola, Arturo Raisaro, Luciano Fattore, Andrea Mauric, Fabrizio Germini, Luca Tedeschi, Maria Settimi, Sergio Nicoli, Paolo Ricciarini, Antonio Argena, Paolo Ronchini, Claudio Bulla, Filippo Tradati, Massimo Volpe, Maria D’Avino, Maria Grazia Bongiorni, Silva Severi, Alessandro Capucci, Corrado Lodigiani, Enrico Salomone, Gaetano Serviddio, Claudio Tondo, Paolo Golino, Carmine Mazzone, Saverio Iacopino, Hugo ten Cate J. H. Ruiter, Andreas Lucassen, Henk Adriaansen, Maarten Bongaerts, Mathijs Pieterse, Coen van Guldener, Johannes Herrman, S. H. K. P. R. Nierop, Pieter Hoogslag, Walter Hermans, B. E. Groenemeijer, W. Terpstra, Cees Buiks, L. V. A. Boersma, Eivind Berge Per Anton Sirnes, Erik Gjertsen, Torstein Hole, Knut Erga, Arne Hallaråker, Gunnar Skjelvan, Anders Østrem, Beraki Ghezai, Arne Svilaas, Peter Christersson, Torbjørn Øien, Svein Høegh Henrichsen, Jan Erik Otterstad, Jan Berg-Johansen, Janina Stepinska Andrzej Gieroba, Malgorzata Biedrzycka, Michal Ogorek, Beata Wozakowska-Kaplon, Krystyna Loboz-Grudzien, Wieslaw Supinski, Jerzy Kuzniar, Roman Zaluska, Jaroslaw Hiczkiewicz, Lucyna Swiatkowska-Byczynska, Lech Kucharski, Marcin Gruchala, Piotr Minc, Maciej Olszewski, Grzegorz Kania, Malgorzata Krzciuk, Zbigniew Lajkowski, Bozenna Ostrowska-Pomian, Jerzy Lewczuk, Elzbieta Zinka, Agnieszka Karczmarczyk, Malgorzata Chmielnicka-Pruszczynska, Iwona Wozniak-Skowerska, Grzegorz Opolski, Marek Bronisz, Marcin Ogorek, Grazyna Glanowska, Piotr Ruszkowski, Grzegorz Skonieczny, Ryszard Sciborski, Boguslaw Okopien, Piotr Kukla, Krzysztof Galbas, Krzysztof Cymerman, Jaroslaw Jurowiecki, Pawel Miekus, Waldemar Myszka, Stanislaw Mazur, Roman Lysek, Jacek Baszak, Teresa Rusicka-Piekarz, Grzegorz Raczak, Ewa Domanska, Jadwiga Nessler, Jozef Lesnik, Vera Eltishcheva Roman Libis, Gadel Kamalov, Dmitry Belenky, Liudmila Egorova, Alexander Khokhlov, Eduard Yakupov, Dmitry Zateyshchikov, Olga Barbarash, Olga Miller, Evgeniy Mazur, Konstantin Zrazhevskiy, Tatyana Novikova, Yulia Moiseeva, Elena Polkanova, Konstantin Sobolev, Maria Rossovskaya, Yulia Shapovalova, Alla Kolesnikova, Konstantin Nikolaev, Oksana Zemlianskaia, Anna Zateyshchikova, Victor Kostenko, Sergey Popov, Maria Poltavskaya, Anton Edin, Elena Aleksandrova Oksana Drapkina, Alexander Vishnevsky, Oleg Nagibovich, Petr Chizhov, Svetlana Rachkova, Mikhail Sergeev, Borys Kurylo, Alexey Ushakov, Xavier Vinolas Pere Alvarez Garcia, Maria Fernanda Lopez Fernandez, Luis Tercedor Sanchez, Salvador Tranche Iparraguirre, Pere Toran Monserrat, Emilio Marquez Contreras, Jordi Isart Rafecas, Juan Motero Carrasco, Pablo Garcia Pavia, Casimiro Gomez Pajuelo, Luis Miguel Rincon Diaz, Luis Fernando Iglesias Alonso, Angel Grande Ruiz, Jordi Merce Klein, Jose Ramon Gonzalez Juanatey, Ines Monte Collado, Herminia Palacin Piquero, Carles Brotons Cuixart, Esther Fernandez Escobar, Joan Bayo i Llibre, Cecilia Corros Vicente, Manuel Vida Gutierrez, Francisco Epelde Gonzalo, Carlos Alexandre Almeida Fernandez, Encarnacion Martinez Navarro, Juan Jose Montero Alia, Maria Barreda Gonzalez, Maria Angels Moleiro Oliva, Jose Iglesias Sanmartin, Mercedes Jimenez Gonzalez, Maria del Mar Rodriguez Alvarez, Juan Herreros Melenchon, Tomas Ripoll Vera, Manuel Jimenez Navarro, Maria Vazquez Caamano, Maria Fe Arcocha Torres, Gonzalo Marcos Gomez, Andres Iniguez Romo, Miguel Angel Prieto Diaz, Mårten Rosenqvist Alexander Wirdby, Jan Lindén, Kerstin Henriksson, Micael Elmersson, Arnor Egilsson, Ulf Börjesson, Gunnar Svärd, Bo Liu, Anders Lindh, Lars-Bertil Olsson, Mikael Gustavsson, Lars Andersson, Lars Benson, Claes Bothin, Ali Hajimirsadeghi, Björn Martinsson, Marianne Ericsson, Åke Ohlsson, Håkan Lindvall, Peter Svensson, Katarina Thörne, Hans Händel, Pyotr Platonov, Fredrik Bernsten, Ingar Timberg, Milita Crisby, Jan-Erik Karlsson, Agneta Andersson, Lennart Malmqvist, Johan Engdahl, Jörgen Thulin, Aida Hot-Bjelak, Steen Jensen, Per Stalby, Jan Steffel Johann Debrunner, Juerg H. Beer, Dipen Shah, Iurii Rudyk Vira Tseluyko, Oleksandr Karpenko, Svitlana Zhurba, Igor Kraiz, Oleksandr Parkhomenko, Iryna Kupnovytska, Nestor Seredyuk, Yuriy Mostovoy, Oleksiy Ushakov, Olena Koval, Igor Kovalskiy, Yevgeniya Svyshchenko, Oleg Sychov, Mykola Stanislavchuk, Andriy Yagensky, Susanna Tykhonova, Ivan Fushtey, Will Murdoch Naresh Chauhan, Daryl Goodwin, Louise Lumley, Ramila Patel, Philip Saunders, Bennett Wong, Alex Cameron, Niranjan Patel, P. Jhittay, Andrew Ross, M. S. Kainth, Karim Ladha, Kevin Douglas, Gill Pickavance, Joanna McDonnell, Laura Handscombe, Trevor Gooding, Helga Wagner, Colin Bradshaw, Catherine Bromham, Kevin Jones, Shoeb Suryani, Richard Coates, Bhupinder Sarai, W. Willcock, S. Sircar, John Cairns, A. Gilliand, Roman Bilas, E. Strieder, Peter Hutchinson, Anne Wakeman, Michael Stokes, Graham Kirby, Bhaskhar Vishwanathan, Nigel Bird, Paul Evans, M. Clark, John Bisatt, Jennifer Litchfield, E. Fisher, Tim Fooks, Richard Kelsall, Neil Paul, Elizabeth Alborough, Michael Aziz, C. Ramesh, Pete Wilson, Simon Franklin, Sue Fairhead, Julian Thompson, Hasan Chowan, Gary Taylor, Dawn Tragen, Matt Parfitt, Claire Seamark, Carolyn Paul, Mark Richardson, Angus Jefferies, Helen Sharp, Hywel Jones, Claire Giles, Matthew Bramley, Philip Williams, Jehad Aldegather, Simon Wetherell, William Lumb, Phil Evans, Frances Scouller, Neil Macey, Stephen Rogers, Yvette Stipp, Richard West, Philip Pinney, Paul Wadeson, John Matthews, Preeti Pandya, Andrew Gallagher, T. Railton, Emyr Davies, Jonathan McClure, Marc Jacobs, Claire Hutton, R. Thompson, Bijoy Sinha, Keith Butter, Susan Barrow, Helen Little, David Russell, Ulka Choudhary, Ikram Haq, Paul Ainsworth, Claire Jones, Phil Weeks, Jane Eden, Lisa Gibbons, Janet Glencross, Alison MacLeod, K. Poland, Conor Mulolland, A. Warke, Paul Conn, D. Burns, R. Smith, R. Kamath, Jonathan Webster, Ian Hodgins, Stephen Vercoe, Paul Roome, Hilary Pinnock, Jayesh Patel, Amar Ali, Nigel Hart, Richard Davies, Nigel De-Sousa, Catherine Neden, Mark Danielsen, Purnima Sharma, Sophia Galloway, Charlotte Hawkins, Raife Oliver, Martin Aylward, Mira Pattni, Gordon Irvine, Shahid Ahmad, Catherine Rothwell, Fiaz Choudhary, Sabrina Khalaque, Stephanie Short, Sharon Peters, Warwick Coulson, Neil Roberts, Amy Butler Steven Coates, Ben Ward, Daniel Jackson, Steve Walton, Diane Shepherd, Toh Wong, Mark Boon, Melanie Deacon, David Cornelius, Sarah Davies, Ben Frankel, Nick Hargreaves, Henry Choi, Jon Sumner, Tim Myhill, Salah Estifanos, Diane Geatch, Justin Wilkinson, Richard Veale, Karen Forshaw, Rob Hirst, Kashif Zaman, Catherine Liley, Rebecca Wastling, Paul McEleny, Andre Beattie, Philip Cooke, Mike Wong, Mark Pugsley, Chaminda Dooldeniya, Greg Rogers, James Bennett, Polly Jacobs, Rajesh Muvva, Matthew Adam, Robin Fox, Nicolas Thomas, Simon Cartwright, Rory Reed, Simon Randfield, Christine A’Court, Ann Flynn, Andrew Halpin, Simon Dobson, Louise Lomax, Minnal Nadaph, Iain Munro, Jane Goram, Helen Stoddart, Phil Simmons, John Shewring, Emma Bowen-Simpkins, Mark Rickenbach, Adam Blenkhorn Bhuwanendu Singh, Penny Astridge, William van Gaal, Walter Abhayaratna, Philip Thomson, Ron Lehman, Jens Kilian, David Coulshed, Andrei Catanchin, David Colquhoun, Hosen Kiat, David Eccleston, John French, Bronte Ayres, Peter Blombery, Thanh Phan, James Rogers, David O’Donnell, Sang Cheol Bae, Harry Gibbs, Patrick Carroll, Greg Starmer, Margaret Arstall, Maurits Binnekamp, Astin Lee, John Eikelboom Robert Luton, Milan Gupta, Amritanshu Shekhar Pandey, Stephen Cheung, Rolland Leader, Philippe Beaudry, Félix Ayala-Paredes, Joseph Berlingieri, John Heath, Germain Poirier, Miranda du Preez, Bradley Schweitzer, Reginald Nadeau, Ripple Dhillon, Tomasz Hruczkowski, Andrea Lavoie, Ratika Parkash, James Cha, Benoit Coutu, Paul MacDonald, Brian Ramjattan, Jorge Bonet, Saul Vizel, Paul Angaran, Sameh Fikry, Ahmed Mowafy Azza Katta, Mazen Tawfik, Moustafa Nawar, Mohamed Sobhy, Seif Kamal Abou Seif, Tarek Khairy, Ahmed Abd El-Aziz, Nasser Taha, Ashraf Reda, Atef Elbahry, Mohamed Setiha, Mohamed Gamal El Din, Magdi Elkhadem, Adel El-Etreby, David Kettles Junaid Bayat, Heidi Siebert, Adrian Horak, Ynez Kelfkens, Riaz Garda, Thayabran Pillay, Michele Guerra, Louis van Zyl, Hendrik Theron, Andrew Murray, Rikus Louw, Deon Greyling, Pindile Mntla, Siddique Ismail, Fayzal Ahmed, Johannes Engelbrecht, Shambu Maharajh, Wessel Oosthuysen, Rehana Loghdey, Veronica Ueckermann, Wael AlAl Mahmeed AbdullahNaeemi, Ghazi Yousef, Nooshin Bazargani, Munther AlOmairi, Rajan Maruthanayagam, Rupesh Singh, Ahmed Naguib, Mohamed Ibrahim, Amrish Agrawal, Mukesh Nathani, Ehab M. Esheiba, Adel Wassef, Rajeev Gupta, Michael Cox Scott Beach, Peter Duffy, Stephen Falkowski, Kevin Ferrick, Miguel Franco, W. Michael Kutayli, Annette Quick, Niraj Sharma, Vance Wilson, Stephen Miller, Mark Alberts, Edwin Blumberg, Roddy Canosa, Ted Gutowski, Rodney Ison, Jorge Garcia, Paul Mullen, Howard Noveck, Pamela Rama, Rajneesh Reddy, Marcus Williams, Daniel Nishijima, Keith Ferdinand, Ihsan Haque, Robert Mendelson, Sridevi Pitta, Daniel Theodoro, Charles Treasure, Moustafa Moustafa, Cas Cader, Walter Pharr, Alisha Oropallo, George Platt, Jaspal Gujral, James Welker, Firas Koura, Sylvia, H, John A, C, Darius, H, Jan, S, Saverio, V, Karen, P, Marianne, B, Sebastian, S, Frank, M, Gloria, K, Kakkar, A, Bassand, J, John Camm, A, Fitzmaurice, D, Fox, K, Gersh, B, Goldhaber, S, Goto, S, Haas, S, Hacke, W, Mantovani, L, Misselwitz, F, Pieper, K, Turpie, A, van Eickels, M, Verheugt, F, Gersh, K, Lucas Luciardi Harry Gibbs, H, Brodmann, M, Cools, F, Carlos Pereira Barretto, A, Connolly, S, Eikelboom, J, Corbalan, R, Jing, Z, Jansky, P, Dalsgaard Nielsen, J, Ragy, H, Raatikainen, P, Le Heuzey, J, Keltai, M, Pal Singh Sawhney, J, Agnelli, G, Ambrosio, G, Koretsune, Y, Jerjes Sánchez Díaz, C, Ten Cate, H, Atar, D, Stepinska, J, Panchenko, E, Wei Lim, T, Jacobson, B, Oh, S, Viñolas, X, Rosenqvist, M, Steffel, J, Angchaisuksiri, P, Oto, A, Parkhomenko, A, Al Mahmeed, W, Hu Kangning Chen, D, Zhao, Y, Zhang, H, Chen, J, Cao, S, Wang, D, Yang, Y, Li, W, Li, H, Yin, Y, Tao, G, Yang, P, Chen, Y, He, S, Wang, Y, Fu, G, Li, X, Wu, T, Cheng, X, Yan, X, Zhao, R, Chen, M, Xiong, L, Chen, P, Jiao, Y, Guo, Y, Xue, L, Yang, Z, Jadhavm Raghava Sarma, P, Kulkarni, G, Chandwani, P, Atulbhai Pothiwala, R, Padinhare Purayil, M, Chawla, K, Annasaheb Kothiwale, V, Raghuraman, B, Madan Vijan, V, Sawhney, J, Bantwal, G, Khan, A, Meena, R, Chopada, M, Abraham, S, Bisne, V, Vijayaraghavan, G, Roy, D, Durgaprasad, R, Ravi Shankar, A, Kumar, S, Jain, D, Bhargava, K, Kumar, V, Madappa Nagamalesh, U, Kumar Rajput, R, Koretsune Seishu Kanamori, Y, Yamamoto, K, Kumagai, K, Katsuda, Y, Yoshida, K, Toyota, F, Mizuno, Y, Misumi, I, Noguchi, H, Ando, S, Suetsugu, T, Minamoto, M, Oda, H, Adachi, S, Chiba, K, Norita, H, Tsuruta, M, Koyanagi, T, Ando, H, Higashi, T, Okada, M, Azakami, S, Komaki, S, Kumeda, K, Murayama, T, Matsumura, J, Oba, Y, Sonoda, R, Goto, K, Minoda, K, Haraguchi, Y, Suefuji, H, Miyagi, H, Kato, H, Nakamura, T, Nandate, H, Zaitsu, R, Fujiura, Y, Yoshimura, A, Numata, H, Ogawa, J, Kamogawa, Y, Murakami, K, Wakasa, Y, Yamasawa, M, Maekawa, H, Abe, S, Kihara, H, Tsunoda, S, Saito, K, Tachibana, H, Oba, I, Kuwahata, T, Higa, S, Gushiken, M, Eto, T, Chibana, H, Fujisawa, K, Shiga, Y, Sumi, H, Nagatomo, T, Atsuchi, Y, Nagoshi, T, Sanno, K, Hoshino, F, Yokota, N, Kameko, M, Tabuchi, T, Ishizawa, M, Ikeda, D, Seto, T, Iwao, T, Ishioka, N, Oshiro, K, Tsuchida, K, Hatori, Y, Takeuchi, M, Takezawa, H, Nagano, S, Iwaki, M, Nakamura, Y, Miyamoto, N, Taguchi, T, Ashida, K, Yoshizawa, N, Agata, J, Matsukawa, S, Arasaki, O, Fukuoka, S, Murakami, H, Mishima, K, Hata, Y, Sakuma, I, Obunai, K, Takamura, I, Akutsu, M, Unoki, T, Go, Y, Ikemura, M, Morii, S, Marusaki, S, Doi, H, Tanaka, M, Kusumoto, T, Kakinoki, S, Ogurusu, C, Murata, K, Shimoyama, M, Nakatsuka, M, Kitami, Y, Oyama, R, Ageta, M, Mita, T, Nagao, K, Mito, T, Minami, J, Abe, M, Fujii, M, Okawa, M, Fujito, T, Taniguchi, T, Ko, T, Kubo, H, Imamaki, M, Akiyama, M, Ueda, T, Odakura, H, Inagaki, M, Katsube, Y, Nakata, A, Tomimoto, S, Shibuya, M, Nakano, M, Ito, K, Matsuta, M, Ishiguro, M, Minagawa, T, Wada, M, Mukawa, H, Mizuguchi, M, Okuda, F, Kimura, T, Taga, K, Techigawara, M, Igarashi, M, Watanabe, H, Seo, T, Hiramitsu, S, Hosokawa, H, Hoshiai, M, Hibino, M, Miyagawa, K, Horie, H, Sugishita, N, Soma, A, Neya, K, Yoshida, T, Akahane, K, Takanaka, C, Matsui, S, Kanda, H, Kaneko, M, Nagasaka, S, Taguchi, A, Toru, S, Miyashita, A, Sasaguri, H, Nariyama, J, Hatsuno, T, Iwase, T, Sato, K, Kawai, K, Kotani, T, Tsuji, T, Sakai, H, Nishino, K, Ikeda, K, Maeda, K, Shinozuka, T, Inoue, T, Kawakami, K, Kitazumi, H, Takagi, T, Hamaoka, M, Kojima, J, Sasaki, A, Tsuchiya, Y, Betsuyaku, T, Higuchi, K, Honda, M, Hasegawa, K, Baba, T, Mineoi, K, Koeda, T, Hirasawa, K, Kumazaki, T, Nakagomi, A, Otaki, E, Shindo, T, Hirayama, H, Sugimoto, C, Yamagishi, T, Mizuguchi, I, Sezaki, K, Niwa, I, Takenaka, K, Iiji, O, Taya, K, Kitazawa, H, Ueda, S, Kakuda, H, Ono, T, Oriso, S, Kamata, J, Nanke, T, Maeda, I, Matsuura, Y, Teragawa, H, Maruyama, Y, Takei, K, Kito, T, Asano, H, Matsushita, K, Nakamura, M, Washizuka, T, Sawano, M, Arima, S, Arai, H, Shinohara, H, Takai, H, Furukawa, N, Ota, A, Aoki, K, Yamamoto, T, Kasai, T, Suzuki, S, Shibata, N, Watanabe, M, Nishihata, Y, Arino, T, Okuyama, M, Wakiyama, T, Kato, T, Sasagawa, Y, Tana, T, Hayashi, Y, Hirota, S, Abe, Y, Saito, Y, Uchiyama, H, Takeda, H, Ono, H, Tohyo, S, Hanazono, N, Miyajima, S, Shimono, H, Aoyama, T, Shozawa, Y, Niijima, Y, Murai, O, Inaba, H, Nomura, K, Nozoe, M, Suzuki, K, Furukawa, T, Shiraiwa, T, Ito, N, Nagai, S, Nakahara, S, Shimoyama, Y, Ohara, N, Kozuka, T, Okita, H, Endo, M, Goto, T, Hirose, M, Nagata, E, Nakanishi, N, Mori, T, Seki, S, Okamoto, K, Moriai, O, Emura, Y, Fukuda, T, Date, H, Kawakami, S, Ueyama, Y, Fudo, T, Imaizumi, M, Ogawa, T, Take, S, Ikeda, H, Nishioka, H, Sakamoto, N, Ikeoka, K, Wakaki, N, Doiuchi, J, Kira, T, Tada, M, Tsuzaki, K, Miura, N, Fujisawa, Y, Furumoto, W, Fujisawa, A, Nakamura, R, Komatsu, H, Fujiki, R, Kawano, S, Nishizawa, K, Kato, Y, Azuma, J, Yasui, K, Amano, T, Sekine, Y, Honzawa, T, Koshibu, Y, Sakamoto, Y, Seta, Y, Miyaguchi, S, Morishita, K, Samejima, Y, Sasaki, T, Iseki, F, Kobayashi, T, Kano, H, Kim, J, Yamaguchi, H, Takagi, Y, Onuki Pearce, Y, Suzuki, Y, Fukui, T, Nakayama, T, Kanai, H, Kawano, Y, Ino, T, Miyoshi, H, Miyamoto, Y, Shigekiyo, M, Ono, S, Okamoto, Y, Ubukata, S, Kodera, K, Oriuchi, T, Matsumoto, N, Inagaki, K, Iseki, A, Goda, T, Katsuki, T, Sato, A, Mori, E, Tsubokura, T, Shudo, H, Fujimoto, S, Katsuya, T, Furukawa, Y, Narumi, J, Owari, M, Inakura, T, Anno, T, Shirakawa, K, Keong Ching Toon Wei Lim, C, Foo, D, Wong, K, Yuyang, T, Oh Hui Nam Park, S, Kim, W, Lee, H, Jang, S, Hyeok Kim, D, Ryu, D, Shim, J, Kim, D, Ju Choi, D, Seog Oh, Y, Cho, M, Kim, H, Jeon, H, Shin, D, Weon Park, S, Ki Park, H, Han, S, Hoon Sung, J, Park, H, Nam, G, Keun On, Y, Euy Lim, H, Kwak, J, Cha, T, Jong Hong, T, Hoon Park, S, Han Yoon, J, Kim, N, Kim, K, Chun Jung, B, Hwang, G, Kim, C, Rungaramsin Peerapat Katekangplu, S, Khunrong, P, Bunyapipat, T, Wongcharoen, W, Kaewsuwanna, P, Siriwattana, K, Tiyanon, W, Pattanaprichakul, S, Likittanasombat, K, Cholsaringkarl, D, Boonyapisit, W, Cheewatanakornkul, S, Silaruks, S, Hutayanon, P, Chawanadelert, S, Chattranukulchai, P, Chatlaong, B, Santanakorn, Y, Kanokphatcharakun, K, Mongkolwongroj, P, Jai-Aue, S, Komson, O, Altun Ali Aydinlar, A, Topsakal, R, Ongen, Z, Acikel, S, Yildiray Sahin, D, Yilmaz, O, Birhan Yilmaz, M, Pekdemir, H, Demir, M, Sucu, M, Sahiner, L, Ersanli, M, Okuyan, E, Aras, D, Rolandi Adrian Cesar Ingaramo, F, Alberto Sambadaro, G, Fernandez Caputi, V, Luciardi, H, Graciela Berman, S, Dragotto, P, Javier Kleiban, A, Centurion, N, Andres Ahuad Guerrero, R, Adalberto Di Paola, L, Dario Dran, R, Egido, J, Jose Fosco, M, Alfredo Sinisi, V, Rodolfo Cartasegna, L, Gomez Vilamajo, O, Luis Ramos, J, Sassone, S, Zapata, G, Conde, D, Giacomi, G, Alfredo Fernandez, A, Alberto Berli, M, Ferroni, F, Celestino Sobral Filho Jefferson Jaber, D, Vidal Armaganijan, L, Roberto Frack Costantini, C, Steffens, A, Kunz Sebba Barroso de Souzaem, W, David de Souza Neto, J, Márcio Ribeiro, J, Silveira Teixeira, M, Rossi, P, Pires, L, Moreira, D, Carlos Moura Jorge, J, Menezes Lorga Filho, A, Bodanese, L, Westerlund Montera, M, Henrique Del Carlo, C, Abdalla Saad, J, Augusto Alves da Costa, F, Lopes, R, Roberto de Araújo, G, Roberto Manenti, E, Francisco Kerr Saraiva, J, Carlos Ferreira Braga, J, Negri, A, Moncada, C, Precoma, D, Roquette, F, Reis, G, Álvaro Ramos Filho, R, Lanna Figueiredo, E, Vieira Botelho, R, Munhoz da Fontoura Tavares, C, Carlos Finimundi, H, Kochi, A, Cássio Broilo França, C, Alban, F, Bernardo Aranha Rosito, G, Batista de Moura Xavier Moraes Junior, J, Tadeu Tumelero, R, Maia, L, Simões de Almeida, R, Carter do Carmo Borges, N, Gustavo Gomes Ferreira, L, Corbalán Benjamin Aleck Joseh Stockins Fernandez, R, Montecinos, H, Lanas, F, Larico Gómez, M, Astudillo, C, Conejeros, C, Marin Cuevas, P, Forero, A, Bugueño Gutiérrez, C, Aguilar, J, Potthoff Cardenas, S, Eggers, G, Houzvic, C, Rey, C, Arriagada, G, Charme Vilches, G, Jerjes Sanchez Diaz Jesus Jaime Illescas Diaz, C, Leal Cantu, R, Guadalupe Ramos Zavala, M, Cabrera Jardines, R, Espinola Zavaleta, N, Lopez Rosas, E, Antonio Llamas Esperón, G, Pozas, G, Cardona Muñoz, E, Matadamas Hernandez, N, Leyva Rendon, A, Garcia Hernandez, N, de los Rios Ibarra, M, Ramon Virgen Carrillo, L, Lopez Villezca, D, Hernandez Herrera, C, Jose Lopez Prieto, J, Gaona Rodriguez, R, Villeda Espinosa, E, Flores Martinez, D, Velasco Barcena, J, Fierro Fierro, O, Rodriguez Briones, I, Luis Leiva Pons, J, Alvarez Lopez, H, Olvera Ruiz, R, Gerardo Cantu Brito, C, Julian Jose Roberto Chuquiure Valenzuela, E, Reyes Sanchez, R, Esteban Bazzoni Ruiz, A, Martin Lopez Ruiz, O, Arriaga Nava, R, David Morales Cerda, J, Fajardo Campos, P, Benavides Gonzalez, M, Brodmann Kurt Lenz, M, Hagn, C, Foechterle, J, Drexel, H, Huber, K, Podczeck-Schweighofer, A, Winkler, M, Schneeweiss, B, Gegenhuber, A, Lang, W, Eichinger-Hasenauer, S, Kaserer, P, Sykora, J, Rasch, H, Strohmer, B, Capiau Geert Vervoort, L, Wollaert, B, Hollanders, G, Vercammen, J, Faes, D, Balthazar, Y, Delforge, M, Xhaet, O, Striekwold, H, Thoeng, J, Hermans, K, Mairesse, G, Anné, W, Blankoff, I, Beutels, M, Verstraete, S, Vandergoten, P, Purnode, P, Godart, P, Boussy, T, Desfontaines, P, Heyse, A, Voet, J, De Wolf, A, Zidkova Petr Jansky, E, Spacek, R, Machova, V, Ludka, O, Olsr, J, Kotik, L, Racz, B, Ferkl, R, Hubac, J, Kotik, I, Monhart, Z, Burianova, H, Jerabek, O, Pisova, J, Petrova, I, Dedek, V, Honkova, M, Podrazil, P, Reichert, P, Spinar, J, Novak, M, Durdil, V, Plocova, K, Lastuvka, J, Nielsen Steen Husted, J, Dominguez, H, Hintze, U, Rasmussen, S, Sygehus, N, Bremmelgaard, A, Markenvard, J, Børger, J, Solgaard, J, Eriksen, E, Løkkegaard, T, Bruun, M, Mertz, J, Schou, M, Olsen, M, Raatikainen Carmela Viitanen, P, Paganelli Joël Ohayon, F, Casassus, F, Galinier, M, Gottwalles, Y, Loiselet, P, Muller, J, Bassel Koujan, M, Marquand, A, Destrac, S, Piot, O, Delarche, N, Cebron, J, Guenoun, M, Guedj-Meynier, D, Lokesh, A, Zuber, M, Amarenco, P, Ellie, E, Kadouch, J, Fournier, P, Huberman, J, Lemaire, N, Rodier, G, Vandamme, X, Sibon, I, Neau, J, Hélène Mahagne, M, Mielot, A, Bonnefoy, M, Churet, J, Navarre, V, Sellem, F, Monniot, G, Boyes, J, Doucet, B, Martelet, M, Obadia, D, Crousillat, B, Mouallem, J, Bearez, E, Philippe Brugnaux, J, Fedorowsky, A, Nazeyrollas, P, Berneau, J, Chemin, F, Schellong Harald Darius, S, Koeniger, G, Kopf, A, Gerbaulet, U, Kellner, B, Schaefer, T, Purr, J, Eißfeller, E, Zauzig, H, Riegel, P, Axthelm, C, Heinz, G, Menke, H, Pustelnik, A, Zutz, S, Eder, W, Rehling, G, Glatzel, D, Ludwig, N, Sandow, P, Wiswedel, H, Wildenauer, C, Schoen, S, Schwarz, T, Babyesiza, A, Kropp, M, Zimny, H, Kahl, F, Caspar, A, Omankowsky, S, Laessig, T, Hartmann, H, Lehmann, G, Bindig, H, Hergdt, G, Reimer, D, Hauk, J, Michel, H, Werner Erdle, P, Dorsch, W, Dshabrailov, J, Rapp, K, Vormann, R, Mueller, T, Mayer, P, Horstmeier, U, Eissing, V, Hey, H, Leuchtgens, H, Lilienweiss, V, Mueller, H, Schubert, C, Lauer, H, Buchner, T, Brauer, G, Kamin, S, Mueller, K, Baumbach, S, Abdel-Qader, M, Ebert, H, Schwencke, C, Bernhardt, P, Karolyi, L, Sievers, B, Haverkamp, W, Roehnisch, J, Vertes Gabor Szantai, A, Matoltsy, A, Kanakaridisz, N, Boda, Z, Kis, E, Gaszner, B, Juhasz, F, Juhasz, G, Kancz, S, Laszlo, Z, May, Z, Merkely, B, Noori, E, Habon, T, Polgar, P, Szalai, G, Vangel, S, Nagy, A, Engelthaler, G, Ferenczi, J, Egyutt, M, Martini Leone Maria Cristina, G, Tiraferri, E, Santoro, R, Testa, S, Di Minno, G, Moia, M, Maria Caimi, T, Tessitori, M, Cappelli, R, Poli, D, Quintavalla, R, Cosmi, F, Fanelli, R, Oriana, V, Reggio, R, Santi, R, Pancaldi, L, De Cristofaro, R, Guazzaloca, G, De Blasio, A, Salerno Uriate, J, Lillo, F, Maria Pogliani, E, Bilo, G, Accogli, M, Mariani, A, Feola, M, Raisaro, A, Fattore, L, Mauric, A, Germini, F, Tedeschi, L, Settimi, M, Nicoli, S, Ricciarini, P, Argena, A, Ronchini, P, Bulla, C, Tradati, F, Volpe, M, D’Avino, M, Grazia Bongiorni, M, Severi, S, Capucci, A, Lodigiani, C, Salomone, E, Serviddio, G, Tondo, C, Golino, P, Mazzone, C, Iacopino, S, Ruiter, H, Lucassen, A, Adriaansen, H, Bongaerts, M, Pieterse, M, van Guldener, C, Herrman, J, Nierop, S, Hoogslag, P, Hermans, W, Groenemeijer, B, Terpstra, W, Buiks, C, Boersma, L, Berge Per Anton Sirnes, E, Gjertsen, E, Hole, T, Erga, K, Hallaråker, A, Skjelvan, G, Østrem, A, Ghezai, B, Svilaas, A, Christersson, P, Øien, T, Høegh Henrichsen, S, Erik Otterstad, J, Berg-Johansen, J, Stepinska Andrzej Gieroba, J, Biedrzycka, M, Ogorek, M, Wozakowska-Kaplon, B, Loboz-Grudzien, K, Jaroslaw, Supinski, W, Kuzniar, J, Zaluska, R, Hiczkiewicz, J, Swiatkowska-Byczynska, L, Kucharski, L, Gruchala, M, Minc, P, Olszewski, M, Kania, G, Krzciuk, M, Lajkowski, Z, Ostrowska-Pomian, B, Lewczuk, J, Zinka, E, Karczmarczyk, A, Chmielnicka-Pruszczynska, M, Wozniak-Skowerska, I, Opolski, G, Bronisz, M, Glanowska, G, Ruszkowski, P, Skonieczny, G, Sciborski, R, Okopien, B, Kukla, P, Galbas, K, Cymerman, K, Jurowiecki, J, Miekus, P, Myszka, W, Mazur, S, Lysek, R, Baszak, J, Rusicka-Piekarz, T, Raczak, G, Domanska, E, Nessler, J, Lesnik, J, Eltishcheva Roman Libis, V, Kamalov, G, Belenky, D, Egorova, L, Khokhlov, A, Yakupov, E, Zateyshchikov, D, Barbarash, O, Miller, O, Mazur, E, Zrazhevskiy, K, Novikova, T, Moiseeva, Y, Polkanova, E, Sobolev, K, Rossovskaya, M, Shapovalova, Y, Kolesnikova, A, Nikolaev, K, Zemlianskaia, O, Zateyshchikova, A, Kostenko, V, Popov, S, Poltavskaya, M, Edin, A, Aleksandrova Oksana Drapkina, E, Vishnevsky, A, Nagibovich, O, Chizhov, P, Rachkova, S, Sergeev, M, Kurylo, B, Ushakov, A, Vinolas Pere Alvarez Garcia, X, Fernanda Lopez Fernandez, M, Tercedor Sanchez, L, Tranche Iparraguirre, S, Toran Monserrat, P, Marquez Contreras, E, Isart Rafecas, J, Motero Carrasco, J, Garcia Pavia, P, Gomez Pajuelo, C, Miguel Rincon Diaz, L, Fernando Iglesias Alonso, L, Grande Ruiz, A, Merce Klein, J, Ramon Gonzalez Juanatey, J, Monte Collado, I, Palacin Piquero, H, Brotons Cuixart, C, Fernandez Escobar, E, i Llibre, J, Corros Vicente, C, Vida Gutierrez, M, Epelde Gonzalo, F, Alexandre Almeida Fernandez, C, Martinez Navarro, E, Jose Montero Alia, J, Barreda Gonzalez, M, Angels Moleiro Oliva, M, Iglesias Sanmartin, J, Jimenez Gonzalez, M, del Mar Rodriguez Alvarez, M, Herreros Melenchon, J, Ripoll Vera, T, Jimenez Navarro, M, Vazquez Caamano, M, Fe Arcocha Torres, M, Marcos Gomez, G, Iniguez Romo, A, Angel Prieto Diaz, M, Rosenqvist Alexander Wirdby, M, Centrumkliniken, Lindén, J, Henriksson, K, Elmersson, M, Egilsson, A, Börjesson, U, Svärd, G, Liu, B, Lindh, A, Olsson, L, Gustavsson, M, Andersson, L, Benson, L, Bothin, C, Hajimirsadeghi, A, Martinsson, B, Ericsson, M, Ohlsson, Å, Lindvall, H, Svensson, P, Thörne, K, Händel, H, Platonov, P, Bernsten, F, Timberg, I, Crisby, M, Karlsson, J, Andersson, A, Malmqvist, L, Engdahl, J, Thulin, J, Hot-Bjelak, A, Jensen, S, Stalby, P, Steffel Johann Debrunner, J, Beer, J, Shah, D, Rudyk Vira Tseluyko, I, Karpenko, O, Zhurba, S, Kraiz, I, Parkhomenko, O, Kupnovytska, I, Seredyuk, N, Mostovoy, Y, Ushakov, O, Koval, O, Kovalskiy, I, Svyshchenko, Y, Sychov, O, Stanislavchuk, M, Yagensky, A, Tykhonova, S, Fushtey, I, Murdoch Naresh Chauhan, W, Goodwin, D, Lumley, L, Patel, R, Saunders, P, Wong, B, Cameron, A, Patel, N, Jhittay, P, Ross, A, Kainth, M, Ladha, K, Douglas, K, Pickavance, G, Mcdonnell, J, Handscombe, L, Gooding, T, Wagner, H, Cumberlidge, Bradshaw, C, Bromham, C, Jones, K, Suryani, S, Coates, R, Sarai, B, Willcock, W, Sircar, S, Cairns, J, Gilliand, A, Bilas, R, Strieder, E, Hutchinson, P, Wakeman, A, Stokes, M, Kirby, G, Vishwanathan, B, Bird, N, Evans, P, Clark, M, Bisatt, J, Litchfield, J, Fisher, E, Fooks, T, Kelsall, R, Paul, N, Alborough, E, Aziz, M, Ramesh, C, Wilson, P, Franklin, S, Fairhead, S, Thompson, J, Chowan, H, Taylor, G, Tragen, D, Parfitt, M, Seamark, C, Paul, C, Richardson, M, Jefferies, A, Sharp, H, Jones, H, Giles, C, Bramley, M, Williams, P, Aldegather, J, Wetherell, S, Lumb, W, Scouller, F, Macey, N, Rogers, S, Stipp, Y, West, R, Pinney, P, Wadeson, P, Matthews, J, Pandya, P, Gallagher, A, Railton, T, Davies, E, Mcclure, J, Jacobs, M, Hutton, C, Thompson, R, Sinha, B, Butter, K, Barrow, S, Little, H, Russell, D, Choudhary, U, Haq, I, Ainsworth, P, Jones, C, Weeks, P, Eden, J, Gibbons, L, Glencross, J, Macleod, A, Poland, K, Mulolland, C, Warke, A, Conn, P, Burns, D, Smith, R, Kamath, R, Webster, J, Hodgins, I, Vercoe, S, Roome, P, Pinnock, H, Patel, J, Ali, A, Hart, N, Davies, R, De-Sousa, N, Neden, C, Danielsen, M, Sharma, P, Galloway, S, Hawkins, C, Oliver, R, Aylward, M, Pattni, M, Irvine, G, Ahmad, S, Rothwell, C, Choudhary, F, Khalaque, S, Short, S, Peters, S, Coulson, W, Roberts, N, Butler Steven Coates, A, Ward, B, Jackson, D, Walton, S, Shepherd, D, Wong, T, Boon, M, Deacon, M, Cornelius, D, Davies, S, Frankel, B, Hargreaves, N, Choi, H, Sumner, J, Myhill, T, Estifanos, S, Geatch, D, Wilkinson, J, Veale, R, Forshaw, K, Hirst, R, Zaman, K, Liley, C, Wastling, R, Mceleny, P, Beattie, A, Cooke, P, Wong, M, Pugsley, M, Dooldeniya, C, Rogers, G, Bennett, J, Jacobs, P, Muvva, R, Adam, M, Fox, R, Thomas, N, Cartwright, S, Reed, R, Randfield, S, A’Court, C, Flynn, A, Halpin, A, Dobson, S, Lomax, L, Nadaph, M, Munro, I, Goram, J, Stoddart, H, Simmons, P, Shewring, J, Bowen-Simpkins, E, Rickenbach, M, Blenkhorn Bhuwanendu Singh, A, Astridge, P, van Gaal, W, Abhayaratna, W, Thomson, P, Lehman, R, Kilian, J, Coulshed, D, Catanchin, A, Colquhoun, D, Kiat, H, Eccleston, D, French, J, Ayres, B, Blombery, P, Phan, T, Rogers, J, O’Donnell, D, Cheol Bae, S, Gibbs, H, Carroll, P, Starmer, G, Arstall, M, Binnekamp, M, Lee, A, Eikelboom Robert Luton, J, Gupta, M, Shekhar Pandey, A, Cheung, S, Leader, R, Beaudry, P, Ayala-Paredes, F, Berlingieri, J, Heath, J, Poirier, G, du Preez, M, Schweitzer, B, Nadeau, R, Dhillon, R, Hruczkowski, T, Lavoie, A, Parkash, R, Cha, J, Coutu, B, Macdonald, P, Ramjattan, B, Bonet, J, Vizel, S, Angaran, P, Fikry, S, Mowafy Azza Katta, A, Tawfik, M, Nawar, M, Sobhy, M, Kamal Abou Seif, S, Khairy, T, Abd El-Aziz, A, Taha, N, Reda, A, Elbahry, A, Setiha, M, Gamal El Din, M, Elkhadem, M, El-Etreby, A, Kettles Junaid Bayat, D, Siebert, H, Horak, A, Kelfkens, Y, Garda, R, Pillay, T, Guerra, M, van Zyl, L, Theron, H, Murray, A, Louw, R, Greyling, D, Mntla, P, Ismail, S, Ahmed, F, Engelbrecht, J, Maharajh, S, Oosthuysen, W, Loghdey, R, Ueckermann, V, AlAl Mahmeed AbdullahNaeemi, W, Yousef, G, Bazargani, N, Alomairi, M, Maruthanayagam, R, Singh, R, Naguib, A, Ibrahim, M, Agrawal, A, Nathani, M, Esheiba, E, Wassef, A, Gupta, R, Cox Scott Beach, M, Duffy, P, Falkowski, S, Ferrick, K, Franco, M, Michael Kutayli, W, Quick, A, Sharma, N, Wilson, V, Miller, S, Alberts, M, Blumberg, E, Canosa, R, Gutowski, T, Ison, R, Garcia, J, Mullen, P, Noveck, H, Rama, P, Reddy, R, Williams, M, Nishijima, D, Ferdinand, K, Haque, I, Mendelson, R, Pitta, S, Theodoro, D, Treasure, C, Moustafa, M, Cader, C, Pharr, W, Oropallo, A, Platt, G, Gujral, J, Welker, J, Koura, F, Haas, Sylvia, Camm, John A, Harald, Darius, Steffel, Jan, Virdone, Saverio, Pieper, Karen, Brodmann, Marianne, Schellong, Sebastian, Misselwitz, Frank, Kayani, Gloria, Ajay K. Kakkar, Jean-Pierre Bassand, A. John Camm, David A. Fitzmaurice, Keith A. A. Fox, Bernard J. Gersh, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Karen S. Pieper, Alexander G. G. Turpie, Martin van Eickels, Freek W. A. Verheugt, Keith A. A. Fox Bernard J. Gersh, Hector Lucas Luciardi Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, John Eikelboom, Ramon Corbalan, Zhi-Cheng Jing, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, Dayi Hu Kangning Chen, Yusheng Zhao, Huaiqin Zhang, Jiyan Chen, Shiping Cao, Daowen Wang, Yuejin Yang, Weihua Li, Hui Li, Yuehui Yin, Guizhou Tao, Ping Yang, Yingmin Chen, Shenghu He, Yong Wang, Guosheng Fu, Xin Li, Tongguo Wu, Xiaoshu Cheng, Xiaowei Yan, Ruiping Zhao, Moshui Chen, Longgen Xiong, Ping Chen, Yang Jiao, Ying Guo, Li Xue, Zhiming Yang, Praveen Jadhavm Raghava Sarma, Govind Kulkarni, Prakash Chandwani, Rasesh Atulbhai Pothiwala, Mohanan Padinhare Purayil, Kamaldeep Chawla, Veerappa Annasaheb Kothiwale, Bagirath Raghuraman, Vinod Madan Vijan, Jitendra Sawhney, Ganapathi Bantwal, Aziz Khan, Ramdhan Meena, Manojkumar Chopada, Sunitha Abraham, Vikas Bisne, Govindan Vijayaraghavan, Debabrata Roy, Rajashekhar Durgaprasad, A. G. Ravi Shankar, Sunil Kumar, Dinesh Jain, Kartikeya Bhargava, Vinay Kumar, Udigala Madappa Nagamalesh, Rajeeve Kumar Rajput, Yukihiro Koretsune Seishu Kanamori, Kenichi Yamamoto, Koichiro Kumagai, Yosuke Katsuda, Keiki Yoshida, Fumitoshi Toyota, Yuji Mizuno, Ikuo Misumi, Hiroo Noguchi, Shinichi Ando, Tetsuro Suetsugu, Masahiro Minamoto, Hiroyuki Oda, Susumu Adachi, Kei Chiba, Hiroaki Norita, Makoto Tsuruta, Takeshi Koyanagi, Kunihiko Yamamoto, Hiroshi Ando, Takayuki Higashi, Megumi Okada, Shiro Azakami, Shinichiro Komaki, Kenshi Kumeda, Takashi Murayama, Jun Matsumura, Yurika Oba, Ryuji Sonoda, Kazuo Goto, Kotaro Minoda, Yoshikuni Haraguchi, Hisakazu Suefuji, Hiroo Miyagi, Hitoshi Kato, Tsugihiro Nakamura, Tadashi Nakamura, Hidekazu Nandate, Ryuji Zaitsu, Yoshihisa Fujiura, Akira Yoshimura, Hiroyuki Numata, Jun Ogawa, Yasuyuki Kamogawa, Kinshiro Murakami, Yutaka Wakasa, Masanori Yamasawa, Hiromitsu Maekawa, Sumihisa Abe, Hajime Kihara, Satoru Tsunoda, Katsumi Saito, Hiroki Tachibana, Ichiro Oba, Takashi Kuwahata, Satoshi Higa, Masamichi Gushiken, Takuma Eto, Hidetoshi Chibana, Kazuaki Fujisawa, Yuhei Shiga, Hirokuni Sumi, Toshihisa Nagatomo, Yoshihiko Atsuchi, Toshiro Nagoshi, Kazuhisa Sanno, Fumihiro Hoshino, Naoto Yokota, Masahiro Kameko, Toshifumi Tabuchi, Munesumi Ishizawa, Yoshitake Fujiura, Daisuke Ikeda, Taku Seto, Tetsu Iwao, Norio Ishioka, Koichi Oshiro, Keizo Tsuchida, Yutaka Hatori, Motoshi Takeuchi, Hiroto Takezawa, Shinjiro Nagano, Masaaki Iwaki, Yuichiro Nakamura, Naomasa Miyamoto, Toshifumi Taguchi, Ko Ashida, Naoto Yoshizawa, Jun Agata, Seishiro Matsukawa, Osamu Arasaki, Shuji Fukuoka, Hirofumi Murakami, Kazuya Mishima, Yoshiki Hata, Ichiro Sakuma, Kotaro Obunai, Ichiro Takamura, Mitsuyuki Akutsu, Toshihide Unoki, Yoshinori Go, Makoto Ikemura, Shoji Morii, Shigeru Marusaki, Hideo Doi, Mitsuru Tanaka, Takaaki Kusumoto, Shigeo Kakinoki, Chiga Ogurusu, Kazuya Murata, Masaki Shimoyama, Masami Nakatsuka, Yutaka Kitami, Yoichi Nakamura, Hiroshi Oda, Rikimaru Oyama, Masato Ageta, Teruaki Mita, Kazuhiko Nagao, Takafumi Mito, Junichi Minami, Mitsunori Abe, Masako Fujii, Makoto Okawa, Tsuneo Fujito, Toshiya Taniguchi, Tenei Ko, Hiroshi Kubo, Mizuho Imamaki, Masahiro Akiyama, Takashi Ueda, Hironori Odakura, Masahiko Inagaki, Yoshiki Katsube, Atsuyuki Nakata, Shinobu Tomimoto, Mitsuhiro Shibuya, Masayuki Nakano, Kenichiro Ito, Masahiro Matsuta, Motoyuki Ishiguro, Taro Minagawa, Masamichi Wada, Hiroaki Mukawa, Masato Mizuguchi, Fumio Okuda, Teruaki Kimura, Kuniaki Taga, Masaaki Techigawara, Morio Igarashi, Hiroshi Watanabe, Toshihiko Seo, Shinya Hiramitsu, Hiroaki Hosokawa, Mitsumoto Hoshiai, Michitaka Hibino, Koichi Miyagawa, Hideki Horie, Nobuyoshi Sugishita, Yukio Shiga, Akira Soma, Kazuo Neya, Tetsuro Yoshida, Kunio Akahane, Sen Adachi, Chiei Takanaka, Saori Matsui, Hirofumi Kanda, Masanori Kaneko, Shiro Nagasaka, Atsushi Taguchi, Shuta Toru, Kazuyuki Saito, Akiko Miyashita, Hiroki Sasaguri, Jin Nariyama, Taketo Hatsuno, Takash Iwase, Kazuki Sato, Kazuya Kawai, Tomobumi Kotani, Tsuyoshi Tsuji, Hirosumi Sakai, Kiyoshi Nishino, Kenichi Ikeda, Kazuo Maeda, Tomohiro Shinozuka, Takeshi Inoue, Koichi Kawakami, Hiromichi Kitazumi, Tsutomu Takagi, Mamoru Hamaoka, Jisho Kojima, Akitoshi Sasaki, Yoshihiro Tsuchiya, Tetsuo Betsuyaku, Koji Higuchi, Masaaki Honda, Koichi Hasegawa, Takao Baba, Kazuaki Mineoi, Toshihiko Koeda, Kunihiko Hirasawa, Toshihide Kumazaki, Akira Nakagomi, Eiji Otaki, Takashi Shindo, Hiroyoshi Hirayama, Chikako Sugimoto, Takashi Yamagishi, Ichiro Mizuguchi, Kazunori Sezaki, Isamu Niwa, Ken Takenaka, Osamu Iiji, Koichi Taya, Hitoshi Kitazawa, samu Ueda, Hirokazu Kakuda, Takuya Ono, Seizo Oriso, Junya Kamata, Toshihiko Nanke, Itaru Maeda, Yoshifusa Matsuura, Hiroki Teragawa, Yasuyuki Maruyama, Kazuo Takei, Hajime Horie, Tetsutaro Kito, Hiroshi Asano, Koji Matsushita, Masaichi Nakamura, Takashi Washizuka, Tomoki Yoshida, Masato Sawano, Shinichi Arima, Hidekazu Arai, Hisanori Shinohara, Hiroyuki Takai, Nobufusa Furukawa, Akira Ota, Kentaro Yamamoto, Kenji Aoki, Taku Yamamoto, Takeaki Kasai, Shunji Suzuki, Shu Suzuki, Nitaro Shibata, Masayuki Watanabe, Yosuke Nishihata, Toru Arino, Masaki Okuyama, Tetsushi Wakiyama, Tomoko Kato, Yasuo Sasagawa, Takeshi Tana, Yoshihito Hayashi, Shinichi Hirota, Yukihiko Abe, Yoshihiro Saito, Hirohide Uchiyama, Hiroshi Takeda, Hiroshi Ono, Shuichi Tohyo, Naoto Hanazono, Seiichi Miyajima, Hisashi Shimono, Takuma Aoyama, Yasunobu Shozawa, Yawara Niijima, Osamu Murai, Hideko Inaba, Katsumasa Nomura, Masatsugu Nozoe, Kazuo Suzuki, Toshiyuki Furukawa, Toshihiko Shiraiwa, Nobuhisa Ito, Shunichi Nagai, Kiyoharu Sato, Shiro Nakahara, Yujin Shimoyama, Naoko Ohara, Teruhiko Kozuka, Hideaki Okita, Masato Endo, Tsutomu Goto, Makoto Hirose, Emiko Nagata, Noriyuki Nakanishi, Toshizumi Mori, Shuichi Seki, Katsuhiro Okamoto, Osamu Moriai, Yoko Emura, Tsuyoshi Fukuda, Haruhiko Date, Shuichi Kawakami, Sho Nagai, Yuya Ueyama, Tetsuro Fudo, Mitsuru Imaizumi, Takuo Ogawa, Shunsuke Take, Hideo Ikeda, Hiroaki Nishioka, Norihiko Sakamoto, Kiyomitsu Ikeoka, Nobuo Wakaki, Masatake Abe, Junji Doiuchi, Tetsuya Kira, Masato Tada, Ken Tsuzaki, Naoya Miura, Yasuaki Fujisawa, Wataru Furumoto, Susumu Suzuki, Akinori Fujisawa, Ryosai Nakamura, Hiroyasu Komatsu, Rei Fujiki, Shuichi Kawano, Keijiro Nishizawa, Yoji Kato, Junya Azuma, Kiyoshi Yasui, Toshio Amano, Yasuhiro Sekine, Tatsuo Honzawa, Yuichiro Koshibu, Yasuhide Sakamoto, Yukihiro Seta, Shingo Miyaguchi, Kojuro Morishita, Yasuko Samejima, Toyoshi Sasaki, Fumiko Iseki, Toshiyuki Kobayashi, Hiroshi Kano, Jaeyoung Kim, Hiroshi Yamaguchi, Yoichi Takagi, Yoko Onuki Pearce, Yasuyuki Suzuki, Takayuki Fukui, Toru Nakayama, Hideaki Kanai, Yoshiyuki Kawano, Tetsuji Ino, Hironori Miyoshi, Yasufumi Miyamoto, Masahito Shigekiyo, Shimato Ono, Yutaka Okamoto, Satoshi Ubukata, Kojiro Kodera, Tatsuo Oriuchi, Naoki Matsumoto, Koichi Inagaki, Atsushi Iseki, Tomohiro Yoshida, Toshihiro Goda, Tsukasa Katsuki, Atsushi Sato, Etsuo Mori, Toshio Tsubokura, Hiroshi Shudo, Shunichi Fujimoto, Tomohiro Katsuya, Yoshiyuki Furukawa, Hiroshi Hosokawa, Jun Narumi, Kiichiro Yamamoto, Masaki Owari, Takuya Inakura, Takafumi Anno, Kazuyuki Shirakawa, Chi Keong Ching Toon Wei Lim, David Foo, Kelvin Wong, Tan Yuyang, Seil Oh Hui Nam Park, Woo-Shik Kim, HyeYoung Lee, Sung-Won Jang, Dae Hyeok Kim, Jun Kim, DongRyeol Ryu, Jaemin Shim, Dae-Kyeong Kim, Dong Ju Choi, Yong Seog Oh, Myeong-Chan Cho, Hack-Lyoung Kim, Hui-Kyung Jeon, Dong-Gu Shin, Sang Weon Park, Hoon Ki Park, Sang-Jin Han, Jung Hoon Sung, Hyung-Wook Park, Gi-Byoung Nam, Young Keun On, Hong Euy Lim, JaeJin Kwak, Tae-Joon Cha, Taek Jong Hong, Seong Hoon Park, Jung Han Yoon, Nam-Ho Kim, Kee-Sik Kim, Byung Chun Jung, Gyo-Seung Hwang, Chong-Jin Kim, Sakda Rungaramsin Peerapat Katekangplu, Porames Khunrong, Thanita Bunyapipat, Wanwarang Wongcharoen, Pinij Kaewsuwanna, Khanchai Siriwattana, Waraporn Tiyanon, Supalerk Pattanaprichakul, Khanchit Likittanasombat, Doungrat Cholsaringkarl, Warangkana Boonyapisit, Sirichai Cheewatanakornkul, Songkwan Silaruks, Pisit Hutayanon, Seksan Chawanadelert, Pairoj Chattranukulchai, Boonsert Chatlaong, Yingsak Santanakorn, Khompiya Kanokphatcharakun, Piya Mongkolwongroj, Sasivimon Jai-Aue, Ongkarn Komson, Armagan Altun Ali Aydinlar, Ramazan Topsakal, Zeki Ongen, Sadik Acikel, Durmus Yildiray Sahin, Ozcan Yilmaz, Mehmet Birhan Yilmaz, Hasan Pekdemir, Mesut Demir, Murat Sucu, Levent Sahiner, Murat Ersanli, Ertugrul Okuyan, Dursun Aras, Florencia Rolandi Adrian Cesar Ingaramo, Gustavo Alberto Sambadaro, Vanina Fernandez Caputi, Hector Luciardi, Sofia Graciela Berman, Pablo Dragotto, Andres Javier Kleiban, Nestor Centurion, Rodolfo Andres Ahuad Guerrero, Leonel Adalberto Di Paola, Ricardo Dario Dran, Javier Egido, Matias Jose Fosco, Victor Alfredo Sinisi, Luis Rodolfo Cartasegna, Oscar Gomez Vilamajo, Jose Luis Ramos, Sonia Sassone, Gerardo Zapata, Diego Conde, Guillermo Giacomi, Alberto Alfredo Fernandez, Mario Alberto Berli, Fabian Ferroni, Dário Celestino Sobral Filho Jefferson Jaber, Luciana Vidal Armaganijan, Costantino Roberto Frack Costantini, André Steffens, Weimar Kunz Sebba Barroso de Souzaem, João David de Souza Neto, José Márcio Ribeiro, Marcelo Silveira Teixeira, Paulo Rossi, Leonardo Pires, Daniel Moreira, José Carlos Moura Jorge, Adalberto Menezes Lorga Filho, Luiz Bodanese, Marcelo Westerlund Montera, Carlos Henrique Del Carlo, Jamil Abdalla Saad, Fernando Augusto Alves da Costa, Renato Lopes, Gilson Roberto de Araújo, Euler Roberto Manenti, Jose Francisco Kerr Saraiva, João Carlos Ferreira Braga, Alexandre Negri, Carlos Moncada, Dalton Precoma, Fernando Roquette, Gilmar Reis, Roberto Álvaro Ramos Filho, Estêvão Lanna Figueiredo, Roberto Vieira Botelho, Cláudio Munhoz da Fontoura Tavares, Helius Carlos Finimundi, Adriano Kochi, César Cássio Broilo França, Fábio Alban, Guido Bernardo Aranha Rosito, João Batista de Moura Xavier Moraes Junior, Rogério Tadeu Tumelero, Lilia Maia, Roberto Simões de Almeida, Ney Carter do Carmo Borges, Luís Gustavo Gomes Ferreira, Ramón Corbalán Benjamin Aleck Joseh Stockins Fernandez, Humberto Montecinos, Fernando Lanas, Martín Larico Gómez, Carlos Astudillo, Carlos Conejeros, Patricio Marin Cuevas, Alejandro Forero, Claudio Bugueño Gutiérrez, Juan Aguilar, Sergio Potthoff Cardenas, German Eggers, Cesar Houzvic, Carlos Rey, Germán Arriagada, Gustavo Charme Vilches, Carlos Jerjes Sanchez Diaz Jesus Jaime Illescas Diaz, Raul Leal Cantu, Maria Guadalupe Ramos Zavala, Ricardo Cabrera Jardines, Nilda Espinola Zavaleta, Enrique Lopez Rosas, Guillermo Antonio Llamas Esperón, Gerardo Pozas, Ernesto Cardona Muñoz, Norberto Matadamas Hernandez, Adolfo Leyva Rendon, Norberto Garcia Hernandez, Manuel de los Rios Ibarra, Luis Ramon Virgen Carrillo, David Lopez Villezca, Carlos Hernandez Herrera, Juan Jose Lopez Prieto, Rodolfo Gaona Rodriguez, Efrain Villeda Espinosa, David Flores Martinez, Jose Velasco Barcena, Omar Fierro Fierro, Ignacio Rodriguez Briones, Jose Luis Leiva Pons, Humberto Alvarez Lopez, Rafael Olvera Ruiz, Carlos Gerardo Cantu Brito, Eduardo Julian Jose Roberto Chuquiure Valenzuela, Roxana Reyes Sanchez, Alberto Esteban Bazzoni Ruiz, Oscar Martin Lopez Ruiz, Roberto Arriaga Nava, Jesus David Morales Cerda, Pedro Fajardo Campos, Mario Benavides Gonzalez, Marianne Brodmann Kurt Lenz, Claus Hagn, Johannes Foechterle, Heinz Drexel, Kurt Huber, Andrea Podczeck-Schweighofer, Michael Winkler, Bruno Schneeweiss, Alfons Gegenhuber, Wilfried Lang, Sabine Eichinger-Hasenauer, Peter Kaserer, Josef Sykora, Heribert Rasch, Bernhard Strohmer, Luc Capiau Geert Vervoort, Bart Wollaert, Geert Hollanders, Jan Vercammen, Dirk Faes, Yohan Balthazar, Marc Delforge, Olivier Xhaet, Harry Striekwold, John Thoeng, Kurt Hermans, Georges Mairesse, Wim Anné, Ivan Blankoff, Michel Beutels, Stefan Verstraete, Peter Vandergoten, Philippe Purnode, Pascal Godart, Tim Boussy, Philippe Desfontaines, Alex Heyse, Joeri Voet, Axel De Wolf, Eva Zidkova Petr Jansky, Rudolf Spacek, Vilma Machova, Ondrej Ludka, Josef Olsr, Lubos Kotik, Blazej Racz, Richard Ferkl, Jan Hubac, Ilja Kotik, Zdenek Monhart, Hana Burianova, Ondrej Jerabek, Jana Pisova, Iveta Petrova, Vratislav Dedek, Michaela Honkova, Petr Podrazil, Petr Reichert, Jindrich Spinar, Miroslav Novak, Vaclav Durdil, Katarina Plocova, Jiri Lastuvka, Jørn Nielsen Steen Husted, Helena Dominguez, Ulrik Hintze, Søren Rasmussen, Næstved Sygehus, Arne Bremmelgaard, John Markenvard, Jan Børger, Jorgen Solgaard, Ebbe Eriksen, Thomas Løkkegaard, Michael Bruun, Jacob Mertz, Morten Schou, Michael Olsen, Pekka Raatikainen Carmela Viitanen, Franck Paganelli Joël Ohayon, Frédéric Casassus, Michel Galinier, Yannick Gottwalles, Philippe Loiselet, Jean-Joseph Muller, Mohamed Bassel Koujan, André Marquand, Sylvain Destrac, Olivier Piot, Nicolas Delarche, Jean-Pierre Cebron, Maxime Guenoun, Dominique Guedj-Meynier, A. G. Lokesh, Mathieu Zuber, Pierre Amarenco, Emmanuel Ellie, James Kadouch, Pierre-Yves Fournier, Jean-Pierre Huberman, Nestor Lemaire, Gilles Rodier, Xavier Vandamme, Igor Sibon, Jean-Philippe Neau, Marie Hélène Mahagne, Antoine Mielot, Marc Bonnefoy, Jean-Baptiste Churet, Vincent Navarre, Frederic Sellem, Gilles Monniot, Jean-Paul Boyes, Bernard Doucet, Michel Martelet, Désiré Obadia, Bernard Crousillat, Joseph Mouallem, Etienne Bearez, Jean Philippe Brugnaux, Alain Fedorowsky, Pierre Nazeyrollas, Jean-Baptiste Berneau, Frédéric Chemin, Sebastien Schellong Harald Darius, Georg Koeniger, Andreas Kopf, Uwe Gerbaulet, Bernd-Thomas Kellner, Thomas Schaefer, Jan Purr, Enno Eißfeller, Heinz-Dieter Zauzig, Peter Riegel, Christoph Axthelm, Gerd-Ulrich Heinz, Holger Menke, Andreas Pustelnik, Stefan Zutz, Wolfgang Eder, Guenter Rehling, Dirk Glatzel, Norbert Ludwig, Petra Sandow, Henning Wiswedel, Cosmas Wildenauer, Steffen Schoen, Toralf Schwarz, Adyeri Babyesiza, Maximilian Kropp, Hans-Hermann Zimny, Friedhelm Kahl, Andreas Caspar, Sabine Omankowsky, Torsten Laessig, Hermann-Josef Hartmann, Gunter Lehmann, Hans-Walter Bindig, Gunter Hergdt, Dietrich Reimer, Joachim Hauk, Holger Michel, Praxis Dres. Werner Erdle, Wilfried Dorsch, Janna Dshabrailov, Karl-Albrecht Rapp, Reinhold Vormann, Thomas Mueller, Peter Mayer, Uwe Horstmeier, Volker Eissing, Heinz Hey, Heinz Leuchtgens, Volker Lilienweiss, Heiner Mueller, Christian Schubert, Herrmann Lauer, Thomas Buchner, Gunter Brauer, Susanne Kamin, Karsten Mueller, Sylvia Baumbach, Muwafeg Abdel-Qader, Hans-Holger Ebert, Carsten Schwencke, Peter Bernhardt, Laszlo Karolyi, Britta Sievers, Wilhelm Haverkamp, Jens-Uwe Roehnisch, Andras Vertes Gabor Szantai, Andras Matoltsy, Nikosz Kanakaridisz, Zoltan Boda, Erno Kis, Balazs Gaszner, Ferenc Juhasz, Gizella Juhasz, Sandor Kancz, Zoltan Laszlo, Zsolt May, Bela Merkely, Ebrahim Noori, Tamas Habon, Peter Polgar, Gabriella Szalai, Sandor Vangel, Andras Nagy, Gabriella Engelthaler, Judit Ferenczi, Mihaly Egyutt, Giuliana Martini Leone Maria Cristina, Eros Tiraferri, Rita Santoro, Sophie Testa, Giovanni Di Minno, Marco Moia, Teresa Maria Caimi, Maria Tessitori, Roberto Cappelli, Daniela Poli, Roberto Quintavalla, Franco Cosmi, Raffaele Fanelli, Vincenzo Oriana, Raffaele Reggio, Roberto Santi, Leonardo Pancaldi, Raimondo De Cristofaro, Giuliana Guazzaloca, Angelo De Blasio, Jorge Salerno Uriate, Flavia Lillo, Enrico Maria Pogliani, Grzegorz Bilo, Michele Accogli, Antonio Mariani, Mauro Feola, Arturo Raisaro, Luciano Fattore, Andrea Mauric, Fabrizio Germini, Luca Tedeschi, Maria Settimi, Sergio Nicoli, Paolo Ricciarini, Antonio Argena, Paolo Ronchini, Claudio Bulla, Filippo Tradati, Massimo Volpe, Maria D’Avino, Maria Grazia Bongiorni, Silva Severi, Alessandro Capucci, Corrado Lodigiani, Enrico Salomone, Gaetano Serviddio, Claudio Tondo, Paolo Golino, Carmine Mazzone, Saverio Iacopino, Hugo ten Cate J. H. Ruiter, Andreas Lucassen, Henk Adriaansen, Maarten Bongaerts, Mathijs Pieterse, Coen van Guldener, Johannes Herrman, S. H. K. P. R. Nierop, Pieter Hoogslag, Walter Hermans, B. E. Groenemeijer, W. Terpstra, Cees Buiks, L. V. A. Boersma, Eivind Berge Per Anton Sirnes, Erik Gjertsen, Torstein Hole, Knut Erga, Arne Hallaråker, Gunnar Skjelvan, Anders Østrem, Beraki Ghezai, Arne Svilaas, Peter Christersson, Torbjørn Øien, Svein Høegh Henrichsen, Jan Erik Otterstad, Jan Berg-Johansen, Janina Stepinska Andrzej Gieroba, Malgorzata Biedrzycka, Michal Ogorek, Beata Wozakowska-Kaplon, Krystyna Loboz-Grudzien, Wieslaw Supinski, Jerzy Kuzniar, Roman Zaluska, Jaroslaw Hiczkiewicz, Lucyna Swiatkowska-Byczynska, Lech Kucharski, Marcin Gruchala, Piotr Minc, Maciej Olszewski, Grzegorz Kania, Malgorzata Krzciuk, Zbigniew Lajkowski, Bozenna Ostrowska-Pomian, Jerzy Lewczuk, Elzbieta Zinka, Agnieszka Karczmarczyk, Malgorzata Chmielnicka-Pruszczynska, Iwona Wozniak-Skowerska, Grzegorz Opolski, Marek Bronisz, Marcin Ogorek, Grazyna Glanowska, Piotr Ruszkowski, Grzegorz Skonieczny, Ryszard Sciborski, Boguslaw Okopien, Piotr Kukla, Krzysztof Galbas, Krzysztof Cymerman, Jaroslaw Jurowiecki, Pawel Miekus, Waldemar Myszka, Stanislaw Mazur, Roman Lysek, Jacek Baszak, Teresa Rusicka-Piekarz, Grzegorz Raczak, Ewa Domanska, Jadwiga Nessler, Jozef Lesnik, Vera Eltishcheva Roman Libis, Gadel Kamalov, Dmitry Belenky, Liudmila Egorova, Alexander Khokhlov, Eduard Yakupov, Dmitry Zateyshchikov, Olga Barbarash, Olga Miller, Evgeniy Mazur, Konstantin Zrazhevskiy, Tatyana Novikova, Yulia Moiseeva, Elena Polkanova, Konstantin Sobolev, Maria Rossovskaya, Yulia Shapovalova, Alla Kolesnikova, Konstantin Nikolaev, Oksana Zemlianskaia, Anna Zateyshchikova, Victor Kostenko, Sergey Popov, Maria Poltavskaya, Anton Edin, Elena Aleksandrova Oksana Drapkina, Alexander Vishnevsky, Oleg Nagibovich, Petr Chizhov, Svetlana Rachkova, Mikhail Sergeev, Borys Kurylo, Alexey Ushakov, Xavier Vinolas Pere Alvarez Garcia, Maria Fernanda Lopez Fernandez, Luis Tercedor Sanchez, Salvador Tranche Iparraguirre, Pere Toran Monserrat, Emilio Marquez Contreras, Jordi Isart Rafecas, Juan Motero Carrasco, Pablo Garcia Pavia, Casimiro Gomez Pajuelo, Luis Miguel Rincon Diaz, Luis Fernando Iglesias Alonso, Angel Grande Ruiz, Jordi Merce Klein, Jose Ramon Gonzalez Juanatey, Ines Monte Collado, Herminia Palacin Piquero, Carles Brotons Cuixart, Esther Fernandez Escobar, Joan Bayo i Llibre, Cecilia Corros Vicente, Manuel Vida Gutierrez, Francisco Epelde Gonzalo, Carlos Alexandre Almeida Fernandez, Encarnacion Martinez Navarro, Juan Jose Montero Alia, Maria Barreda Gonzalez, Maria Angels Moleiro Oliva, Jose Iglesias Sanmartin, Mercedes Jimenez Gonzalez, Maria del Mar Rodriguez Alvarez, Juan Herreros Melenchon, Tomas Ripoll Vera, Manuel Jimenez Navarro, Maria Vazquez Caamano, Maria Fe Arcocha Torres, Gonzalo Marcos Gomez, Andres Iniguez Romo, Miguel Angel Prieto Diaz, Mårten Rosenqvist Alexander Wirdby, Jan Lindén, Kerstin Henriksson, Micael Elmersson, Arnor Egilsson, Ulf Börjesson, Gunnar Svärd, Bo Liu, Anders Lindh, Lars-Bertil Olsson, Mikael Gustavsson, Lars Andersson, Lars Benson, Claes Bothin, Ali Hajimirsadeghi, Björn Martinsson, Marianne Ericsson, Åke Ohlsson, Håkan Lindvall, Peter Svensson, Katarina Thörne, Hans Händel, Pyotr Platonov, Fredrik Bernsten, Ingar Timberg, Milita Crisby, Jan-Erik Karlsson, Agneta Andersson, Lennart Malmqvist, Johan Engdahl, Jörgen Thulin, Aida Hot-Bjelak, Steen Jensen, Per Stalby, Jan Steffel Johann Debrunner, Juerg H. Beer, Dipen Shah, Iurii Rudyk Vira Tseluyko, Oleksandr Karpenko, Svitlana Zhurba, Igor Kraiz, Oleksandr Parkhomenko, Iryna Kupnovytska, Nestor Seredyuk, Yuriy Mostovoy, Oleksiy Ushakov, Olena Koval, Igor Kovalskiy, Yevgeniya Svyshchenko, Oleg Sychov, Mykola Stanislavchuk, Andriy Yagensky, Susanna Tykhonova, Ivan Fushtey, Will Murdoch Naresh Chauhan, Daryl Goodwin, Louise Lumley, Ramila Patel, Philip Saunders, Bennett Wong, Alex Cameron, Niranjan Patel, P. Jhittay, Andrew Ross, M. S. Kainth, Karim Ladha, Kevin Douglas, Gill Pickavance, Joanna McDonnell, Laura Handscombe, Trevor Gooding, Helga Wagner, Colin Bradshaw, Catherine Bromham, Kevin Jones, Shoeb Suryani, Richard Coates, Bhupinder Sarai, W. Willcock, S. Sircar, John Cairns, A. Gilliand, Roman Bilas, E. Strieder, Peter Hutchinson, Anne Wakeman, Michael Stokes, Graham Kirby, Bhaskhar Vishwanathan, Nigel Bird, Paul Evans, M. Clark, John Bisatt, Jennifer Litchfield, E. Fisher, Tim Fooks, Richard Kelsall, Neil Paul, Elizabeth Alborough, Michael Aziz, C. Ramesh, Pete Wilson, Simon Franklin, Sue Fairhead, Julian Thompson, Hasan Chowan, Gary Taylor, Dawn Tragen, Matt Parfitt, Claire Seamark, Carolyn Paul, Mark Richardson, Angus Jefferies, Helen Sharp, Hywel Jones, Claire Giles, Matthew Bramley, Philip Williams, Jehad Aldegather, Simon Wetherell, William Lumb, Phil Evans, Frances Scouller, Neil Macey, Stephen Rogers, Yvette Stipp, Richard West, Philip Pinney, Paul Wadeson, John Matthews, Preeti Pandya, Andrew Gallagher, T. Railton, Emyr Davies, Jonathan McClure, Marc Jacobs, Claire Hutton, R. Thompson, Bijoy Sinha, Keith Butter, Susan Barrow, Helen Little, David Russell, Ulka Choudhary, Ikram Haq, Paul Ainsworth, Claire Jones, Phil Weeks, Jane Eden, Lisa Gibbons, Janet Glencross, Alison MacLeod, K. Poland, Conor Mulolland, A. Warke, Paul Conn, D. Burns, R. Smith, R. Kamath, Jonathan Webster, Ian Hodgins, Stephen Vercoe, Paul Roome, Hilary Pinnock, Jayesh Patel, Amar Ali, Nigel Hart, Richard Davies, Nigel De-Sousa, Catherine Neden, Mark Danielsen, Purnima Sharma, Sophia Galloway, Charlotte Hawkins, Raife Oliver, Martin Aylward, Mira Pattni, Gordon Irvine, Shahid Ahmad, Catherine Rothwell, Fiaz Choudhary, Sabrina Khalaque, Stephanie Short, Sharon Peters, Warwick Coulson, Neil Roberts, Amy Butler Steven Coates, Ben Ward, Daniel Jackson, Steve Walton, Diane Shepherd, Toh Wong, Mark Boon, Melanie Deacon, David Cornelius, Sarah Davies, Ben Frankel, Nick Hargreaves, Henry Choi, Jon Sumner, Tim Myhill, Salah Estifanos, Diane Geatch, Justin Wilkinson, Richard Veale, Karen Forshaw, Rob Hirst, Kashif Zaman, Catherine Liley, Rebecca Wastling, Paul McEleny, Andre Beattie, Philip Cooke, Mike Wong, Mark Pugsley, Chaminda Dooldeniya, Greg Rogers, James Bennett, Polly Jacobs, Rajesh Muvva, Matthew Adam, Robin Fox, Nicolas Thomas, Simon Cartwright, Rory Reed, Simon Randfield, Christine A’Court, Ann Flynn, Andrew Halpin, Simon Dobson, Louise Lomax, Minnal Nadaph, Iain Munro, Jane Goram, Helen Stoddart, Phil Simmons, John Shewring, Emma Bowen-Simpkins, Mark Rickenbach, Adam Blenkhorn Bhuwanendu Singh, Penny Astridge, William van Gaal, Walter Abhayaratna, Philip Thomson, Ron Lehman, Jens Kilian, David Coulshed, Andrei Catanchin, David Colquhoun, Hosen Kiat, David Eccleston, John French, Bronte Ayres, Peter Blombery, Thanh Phan, James Rogers, David O’Donnell, Sang Cheol Bae, Harry Gibbs, Patrick Carroll, Greg Starmer, Margaret Arstall, Maurits Binnekamp, Astin Lee, John Eikelboom Robert Luton, Milan Gupta, Amritanshu Shekhar Pandey, Stephen Cheung, Rolland Leader, Philippe Beaudry, Félix Ayala-Paredes, Joseph Berlingieri, John Heath, Germain Poirier, Miranda du Preez, Bradley Schweitzer, Reginald Nadeau, Ripple Dhillon, Tomasz Hruczkowski, Andrea Lavoie, Ratika Parkash, James Cha, Benoit Coutu, Paul MacDonald, Brian Ramjattan, Jorge Bonet, Saul Vizel, Paul Angaran, Sameh Fikry, Ahmed Mowafy Azza Katta, Mazen Tawfik, Moustafa Nawar, Mohamed Sobhy, Seif Kamal Abou Seif, Tarek Khairy, Ahmed Abd El-Aziz, Nasser Taha, Ashraf Reda, Atef Elbahry, Mohamed Setiha, Mohamed Gamal El Din, Magdi Elkhadem, Adel El-Etreby, David Kettles Junaid Bayat, Heidi Siebert, Adrian Horak, Ynez Kelfkens, Riaz Garda, Thayabran Pillay, Michele Guerra, Louis van Zyl, Hendrik Theron, Andrew Murray, Rikus Louw, Deon Greyling, Pindile Mntla, Siddique Ismail, Fayzal Ahmed, Johannes Engelbrecht, Shambu Maharajh, Wessel Oosthuysen, Rehana Loghdey, Veronica Ueckermann, Wael AlAl Mahmeed AbdullahNaeemi, Ghazi Yousef, Nooshin Bazargani, Munther AlOmairi, Rajan Maruthanayagam, Rupesh Singh, Ahmed Naguib, Mohamed Ibrahim, Amrish Agrawal, Mukesh Nathani, Ehab M. Esheiba, Adel Wassef, Rajeev Gupta, Michael Cox Scott Beach, Peter Duffy, Stephen Falkowski, Kevin Ferrick, Miguel Franco, W. Michael Kutayli, Annette Quick, Niraj Sharma, Vance Wilson, Stephen Miller, Mark Alberts, Edwin Blumberg, Roddy Canosa, Ted Gutowski, Rodney Ison, Jorge Garcia, Paul Mullen, Howard Noveck, Pamela Rama, Rajneesh Reddy, Marcus Williams, Daniel Nishijima, Keith Ferdinand, Ihsan Haque, Robert Mendelson, Sridevi Pitta, Daniel Theodoro, Charles Treasure, Moustafa Moustafa, Cas Cader, Walter Pharr, Alisha Oropallo, George Platt, Jaspal Gujral, James Welker, and Firas Koura
Abstract: Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is a worldwide non-interventional study of stroke prevention in patients with non-valvular AF. Methods and results: 52,080 patients with newly diagnosed AF were prospectively enrolled from 2010 to 2016. 4121 (7.9%) of these patients were recruited in DACH [Germany (n = 3567), Austria (n = 465) and Switzerland (n = 89) combined], and 47,959 patients were from 32 countries in other regions worldwide (ORW). Hypertension was most prevalent in DACH and ORW (85.3% and 75.6%, respectively). Diabetes, hypercholesterolaemia, carotid occlusive disease and vascular disease were more prevalent in DACH patients vs ORW (27.6%, 49.4%, 5.8% and 29.0% vs 21.7%, 40.9%, 2.8% and 24.5%). The use of non-vitamin K antagonist oral anticoagulants (NOACs) increased more in DACH over time. Management of vitamin K antagonists was suboptimal in DACH and ORW (time in therapeutic range of INR ≥ 65% in 44.6% and 44.4% of patients or ≥ 70% in 36.9% and 36.0% of patients, respectively). Adjusted rates of cardiovascular mortality and MI/ACS were higher in DACH while non-haemorrhagic stroke/systemic embolism was lower after 2-year follow-up. Conclusions: Similarities and dissimilarities in AF management and clinical outcomes are seen in DACH and ORW. The increased use of NOAC was associated with a mismatch of risk-adapted anticoagulation (over-and-undertreatment) in DACH. Suboptimal control of INR requires educational activities in both regional groups. Higher rates of cardiovascular death in DACH may reflect the higher risk profile of these patients and lower rates of non-haemorrhagic stroke could be associated with increased NOAC use. Graphical abstract: [Figure not available: see fulltext.].
Published: 2023

38. A resected case of pancreatic adenosquamous carcinoma in which both adenocarcinoma and squamous cell carcinoma components were confirmed by liquid-based cytology

Author: Yukako SHINODA, Yoshiki NAITO, Hideyuki ABE, Yorihiko TAKASE, Kazuya MURATA, Ryo MAKINO, Takato KUMAGAE, Yoshinobu OKABE, Akihiko KAWAHARA, and Jun AKIBA
Subjects: General Medicine
Published: 2022
Full Text: View/download PDF

39. Cytological features of epithelial-mesenchymal transition cells in effusion cytology in cases of pancreatic cancer

Author: Kazuya MURATA, Akihiko KAWAHARA, Yoshiki NAITO, Eiji SADASHIMA, Hideyuki ABE, Yorihiko TAKASE, Chihiro FUKUMITSU, Yukako SHINODA, Ryo MAKINO, Takato KUMAGAE, and Jun AKIBA
Published: 2022
Full Text: View/download PDF

40. Evaluation of cytomorphological findings and diagnostic efficacy in liquid-based cytology and smear cytology of pancreatic endoscopic ultrasound-guided fine-needle aspiration

Author: Yorihiko TAKASE, Yoshiki NAITO, Akihiko KAWAHARA, Eiji SADASHIMA, Hideyuki ABE, Kazuya MURATA, Ryo MAKINO, Chihiro FUKUMITSU, Yukako SHINODA, Yoshinobu OKABE, and Jun AKIBA
Published: 2022
Full Text: View/download PDF

41. Incidence of sarcopenic obesity in older patients with diabetes and association between sarcopenic obesity and higher-level functional capacity: evaluation based on a consensus statement

Author: Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, Kaoru Okubo, Kentaro Azuma, and Kazuya Murata
Subjects: Endocrinology, Endocrinology, Diabetes and Metabolism
Published: 2023
Full Text: View/download PDF

42. PO-02-038 LESION SIZE PREDICTION MODULE-GUIDED RADIOFREQUENCY ABLATION VERSUS CRYOBALLOON ABLATION FOR PAROXYSMAL ATRIAL FIBRILLATION: A PROPENSITY SCORE MATCHED ANALYSIS

Author: Kazuya Murata, Osamu Inaba, Hirofumi Arai, Yuichiro Sagawa, Yasuteru Yamanchi, Masahiko Goya, and Tetsuo Sasano
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Published: 2023
Full Text: View/download PDF

43. [Loneliness is associated with a reduced higher-level-function capacity in older diabetic patients]

Author: Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, Kaoru Okubo, Kentaro Azuma, and Kazuya Murata
Subjects: Diabetes Mellitus, Humans, Geriatrics and Gerontology, Tokyo, Aged
Abstract: The present study examined the relationship between loneliness and higher-level functions in elderly diabetic patients.The subjects were diabetic patients ≥65 years old who were outpatients at Ise Red Cross Hospital. The Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC), a self-administered questionnaire, was used to assess higher-level functions. To evaluate loneliness, we used a shortened version of the Japanese version of the loneliness scale, a self-administered questionnaire. A multiple regression analysis with TMIG-IC scores as the dependent variable, loneliness as the explanatory variable, and adjustment variables was used to calculate the adjusted partial regression coefficients of loneliness on higher-level functions.One hundred and seventy patients were included in the present analysis. Ninety-one patients (53.5%) had loneliness, and the mean TMIG-IC score was 11.3. The unadjusted and adjusted partial regression coefficients of loneliness on higher-level functions were -1.61 (95% confidence interval [CI], -2.31 to -0.91;0.001) and -0.88 (95% CI, -1.52 to -0.23; P=0.008), respectively.Loneliness in elderly diabetic patients was found to be associated with lower higher-level functions. It is important to remind patients with diabetes mellitus who have loneliness about the risk of a decline in their higher-level functions.
Published: 2022

44. Efficient production of large deletion and gene fragment knock-in mice mediated by genome editing with Cas9-mouse Cdt1 in mouse zygotes

Author: Natsumi Iki, Yoshihiro Miwa, Yoshihisa Ikeda, Yuichi Obata, Yoshikazu Hasegawa, Elzeftawy Abdelaziz Elsayed Ibrahim, Hoai Thu Le, Toshiaki Nakashiba, Ken-ichi Yagami, Satoru Takahashi, Kenichi Nakashima, Saori Mizuno-Iijima, Miki Okada-Iwabu, Seiya Mizuno, Miyuki Ishida, Atsuo Ogura, Kazuya Murata, Masato Iwabu, Yoko Daitoku, Tra Thi Huong Dinh, Yoko Tanimoto, Yuko Hamada, Hayate Suzuki, Shinya Ayabe, Fumihiro Sugiyama, Atsushi Yoshiki, Michito Hamada, Shogo Matoba, and Kanako Kato
Subjects: Genetically modified mouse, Zygote, Cell Cycle Proteins, Biology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Mice, Genome editing, Gene knockin, CRISPR, Animals, Humans, Gene Knock-In Techniques, Allele, Indel, Molecular Biology, Gene, 030304 developmental biology, Gene Editing, 0303 health sciences, 030302 biochemistry & molecular biology, HEK 293 cells, Cell biology, DNA-Binding Proteins, HEK293 Cells, embryonic structures, CRISPR-Cas Systems
Abstract: Genetically modified mouse models are essential for in vivo investigation of gene function and human disease research. Targeted mutations can be introduced into mouse embryos using genome editing technology such as CRISPR-Cas. Although mice with small indel mutations can be produced, the production of mice carrying large deletions or gene fragment knock-in alleles remains inefficient. We introduced the nuclear localisation property of Cdt1 protein into the CRISPR-Cas system for efficient production of genetically engineered mice. Mouse Cdt1-connected Cas9 (Cas9-mC) was present in the nucleus of HEK293T cells and mouse embryos. Cas9-mC induced a bi-allelic full deletion of Dmd, GC-rich fragment knock-in, and floxed allele knock-in with high efficiency compared to standard Cas9. These results indicate that Cas9-mC is a useful tool for producing mouse models carrying targeted mutations.
Published: 2021

45. Genome Mining Discovery of Protegenins A–D, Bacterial Polyynes Involved in the Antioomycete and Biocontrol Activities of Pseudomonas protegens

Author: Kenji Kai, Mayuna Suenaga, and Kazuya Murata
Subjects: 0301 basic medicine, biology, 010405 organic chemistry, Chemistry, Mutant, Biological pest control, General Medicine, biology.organism_classification, 01 natural sciences, Biochemistry, 0104 chemical sciences, Pythium ultimum, 03 medical and health sciences, Pseudomonas protegens, 030104 developmental biology, Gene cluster, Molecular Medicine, Genome mining, Gene, Bacteria
Abstract: Some bacteria uniquely produce "bacterial polyynes", which possess a conjugated C≡C bond starting with a terminal alkyne, and use them as chemical weapons against hosts and competitors. Pseudomonas protegens Cab57, a biocontrol agent against plant pathogens, has an orphan biosynthetic gene cluster for bacterial polyynes (named protegenins). In this study, the isolation, structure elucidation, and biological characterization of protegenins A-D are reported. The structures of protegenins A-D determined by spectroscopic and chemical techniques were octadecanoic acid derivatives possessing an ene-tetrayne, ene-triyne-ene, or ene-triyne moiety. The protegenins exhibited weak to strong antioomycete activity against Pythium ultimum OPU774. The deletion of proA, a protegenin biosynthetic gene, resulted in the reduction of the antioomycete activity of P. protegens. The Gac/Rsm system, a quorum sensing-like system of Pseudomonas bacteria, regulated the production of protegenins. The production profile of protegenins was dependent on the culturing conditions, suggesting a control mechanism for protegenin production selectivity. P. protegens suppressed the damping-off of cucumber seedlings caused by P. ultimum, and this protective effect was reduced in the proA-deletion mutant. Altogether, protegenins are a new class of bacterial polyynes which contribute to the antioomycete and plant-protective effects of P. protegens.
Published: 2021
Full Text: View/download PDF

46. Efficient induction of proximity-dependent labelling by biotin feeding in BMAL1-BioID knock-in mice

Author: Tsukasa Okiyoneda, Yoko Daitoku, Tomoyuki Fujiyama, Natsuki Mikami, Kazuya Murata, Kanako Kato, Natsumi Iki, Tra Thi Huong Dinh, Yoko Tanimoto, Asuka Mimura, Yuko Hamada, Hayate Suzuki, Seiya Mizuno, Miyuki Ishida, and Fumihiro Sugiyama
Subjects: endocrine system, Genotype, Biotin, CLOCK Proteins, Endogeny, Biochemistry, Protein biotinylation, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Gene knockin, Protein Interaction Mapping, Animals, Humans, Biotinylation, Carbon-Nitrogen Ligases, Molecular Biology, 030304 developmental biology, Mice, Inbred ICR, 0303 health sciences, Staining and Labeling, Muscles, HEK 293 cells, ARNTL Transcription Factors, Brain, General Medicine, Fibroblasts, Fusion protein, Diet, Cell biology, Mice, Inbred C57BL, HEK293 Cells, chemistry, 030217 neurology & neurosurgery
Abstract: Proximity-dependent biotin identification (BioID) is a useful method to identify unknown protein–protein interactions. Few reports have described genetically engineered knock-in mouse models for in vivo BioID. Thus, little is known about the proper method for biotin administration and which tissues are applicable. Here, we established a BioID knock-in mouse model of Brain and Muscle ARNT-Like 1 (BMAL1) and the BirA biotin ligase with R118G mutation (BirA*). The BMAL1-BioID mouse model was used to investigate the effect of biotin diet feeding on protein biotinylation in several tissues. The BMAL1-BirA* fusion protein-retained proper intracellular localization of BMAL1 and binding to CLOCK protein in HEK293T cells. A biotin labelling assay in mouse embryonic fibroblasts revealed the protein biotinylation activity of BMAL1-BirA* expressed in knock-in mouse cells depending on biotin supplementation. Lastly, feeding a 0.5% biotin diet for 7 days induced protein biotinylation in the brain, heart, testis and liver of BMAL1-BioID mice without adverse effects on spermatogenesis. In the kidney, the biotin diet increased biotinylated protein levels in BMAL1-BioID and control mice, suggesting the existence of endogenous biotinylation activity. These results provide valuable information to optimize the in vivo BioID procedure.
Published: 2021
Full Text: View/download PDF

47. Proposal and Development Prototype of Markers-type Mouse System with Considering Practical and Entertainment.

Author: Kazuya Murata and Takayuki Fujimoto
Published: 2012
Full Text: View/download PDF

48. Impact of diagnosis‐to‐ablation time on non‐pulmonary vein triggers and ablation outcomes in persistent atrial fibrillation

Author: Yoshihide Takahashi, Masahiko Goya, Osamu Inaba, Takashi Ikenouchi, Yukihiro Inamura, Tetsuo Sasano, Akira Sato, Junichi Nitta, Kazuya Murata, Tomomasa Takamiya, and Toshikazu Kono
Subjects: medicine.medical_specialty, medicine.medical_treatment, Catheter ablation, 030204 cardiovascular system & hematology, Pulmonary vein, 03 medical and health sciences, 0302 clinical medicine, Recurrence, Physiology (medical), Internal medicine, Atrial Fibrillation, mental disorders, medicine, Humans, 030212 general & internal medicine, Vein, Coronary sinus, business.industry, Hazard ratio, Odds ratio, Ablation, Treatment Outcome, medicine.anatomical_structure, Pulmonary Veins, Persistent atrial fibrillation, Catheter Ablation, Cardiology, Female, Atrial Premature Complexes, Cardiology and Cardiovascular Medicine, business
Abstract: INTRODUCTION Non-pulmonary vein (PV) triggers are a major cause of atrial tachyarrhythmia (ATA) recurrence after catheter ablation. However, the effect of the diagnosis-to-ablation time (DAT) on non-PV triggers in persistent atrial fibrillation is unknown. METHODS AND RESULTS This observational study evaluated 502 consecutive persistent AF patients who underwent initial ablation. We compared 408 patients whose DAT was
Published: 2021
Full Text: View/download PDF

49. The Expression of PEDF and its Putative Receptors in Hepatocellular Carcinoma and Background Liver Tissue

Author: Kazuya Murata, Sho-ichi Yamagishi, Osamu Nakashima, Hironori Kusano, Eiji Sadashima, Takanori Matsui, Hirohisa Yano, Yoshiki Naito, Yoshinao Kinjou, Jun Akiba, Takafumi Yoshida, Koji Okuda, Shinji Mizuochi, Toru Hisaka, Yutaro Mihara, and Hisamune Sakai
Subjects: Male, Receptors, Neuropeptide, Cancer Research, Carcinoma, Hepatocellular, Receptors, Laminin, PEDF, Liver tissue, Humans, Medicine, Neoplasm Invasiveness, Nerve Growth Factors, Eye Proteins, Receptor, Serpins, Serum Albumin, chemistry.chemical_classification, business.industry, Liver Neoplasms, Lipase, General Medicine, HCCS, Prognosis, medicine.disease, Immunohistochemistry, digestive system diseases, Liver, Oncology, chemistry, Hepatocellular carcinoma, Adipose triglyceride lipase, Cancer research, Female, business, Glycoprotein
Abstract: Background/aim Hepatocellular carcinoma (HCC) remains one of the biggest medical issues. Pigment epithelial-derived factor (PEDF) is a glycoprotein that belongs to the superfamily of serine protease inhibitors. PEDF interacts with its two receptors, adipose triglyceride lipase (ATGL) and laminin receptor (LR). Materials and methods We conducted immunohistochemical staining for PEDF, LR and ATGL in 151 resected HCCs and their background liver tissues. Results High expression of LR in HCC was associated with high histological grade and portal vein invasion, while high expression of PEDF in HCC was associated with absence of portal vein invasion. High LR expression in background liver was statistically associated with low serum albumin levels and was an independent prognostic factor of worse outcomes. No cases with more than 5% fatty degeneration in the background liver tissue showed high PEDF expression. Conclusion PEDF/LR/ATGL could be potential biomarkers in HCC and various chronic hepatic disorders.
Published: 2021
Full Text: View/download PDF

50. Multimodal treatment program for elderly diabetic patients with sarcopenia improves the muscle strength and physical function

Author: Kaoru Okubo, Kanako Imataka, Ryutaro Kaneko, Ryoko Fujiwara, Mai Katsuta, Satoshi Ida, Kentaro Azuma, Kazuya Murata, and Yoshitaka Shirakura
Subjects: Male, Sarcopenia, medicine.medical_specialty, business.industry, Significant difference, Physical function, medicine.disease, Combined Modality Therapy, Grip strength, Diabetes mellitus, Diabetes Mellitus, medicine, Muscle strength, Physical therapy, Humans, Multimodal treatment, Female, Muscle Strength, Geriatrics and Gerontology, Muscle, Skeletal, business, Bioelectrical impedance analysis, Aged
Abstract: OBJECTIVE To evaluate the effects of a multimodal treatment program on the muscle strength, physical function, and skeletal muscle mass in elderly diabetic patients with sarcopenia. METHODS Diabetic patients over 65 years old attending the Department of Diabetes and Metabolism, Ise Red Cross Hospital, were included. The diagnosis of sarcopenia was based on the Asian Working Group for Sarcopenia 2019. The measurement of extremity skeletal muscle mass was assessed by the multi-frequency bioelectrical impedance method, muscle strength was assessed by the grip strength, and the physical function was assessed by the 5-time chair stand test. The muscle strength, physical function, extremity skeletal muscle mass, and other parameters were assessed before and after 12 weeks of the multimodal treatment program (optimization of protein intake, resistance training, and patient education on sarcopenia) and then compared. Paired t-tests were used for the statistical analysis. RESULTS Fourteen patients (3 men and 11 women) were included in the analysis of this study. The mean age was 74.4±4.7 years old. Significant improvements in the grip strength (male, 23.2±5.6 kg to 25.6±5.5 kg, P=0.014; female, 15.5±5.0 kg to 18.9±5.0 kg, P
Published: 2021
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Database

Publisher

377 results on '"Kazuya Murata"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources