1. Increased apoptosis rate by hyperthermochemoradiotherapy for advanced rectal cancers
- Author
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Masaharu Ogaki, Toshio Takahashi, Chouhei Sakakura, Johge Inazawa, Kazumasa Koide, Junya Yamazaki, Hiroki Taniguchi, Tatsuo Abe, Akeo Hagiwara, Shirasu M, Daisuke Ichikawa, Toshiharu Yamaguchi, and Motomi Wakasa
- Subjects
Oncology ,Hyperthermia ,medicine.medical_specialty ,Antimetabolites, Antineoplastic ,Colorectal cancer ,Apoptosis ,Surgical oncology ,Administration, Rectal ,Internal medicine ,Medicine ,Humans ,Prospective Studies ,business.industry ,Rectal Neoplasms ,Therapeutic effect ,General Medicine ,Hyperthermia, Induced ,medicine.disease ,Tumor tissue ,In vitro ,Chemotherapy, Adjuvant ,Cancer cell ,Surgery ,Radiotherapy, Adjuvant ,Fluorouracil ,business ,human activities - Abstract
Apoptosis induced in cancer cells by ionizing radiation, hyperthermia, and 5-fluorouracil (5-FU), termed "hyperthermochemoradiotherapy" (HCR), has been well studied in vitro; however, the role of apoptosis in the tumocidal effect of HCR for primary rectal cancers has not yet been clarified. Therefore, we examined the relationship between the therapeutic effect and induction rate of histological apoptosis in 16 patients with rectal cancers after HCR. Numerous Tunel-positive apoptotic cells were found in the tumor tissue after HCR, but few were found in the tumors which had not received HCR. The histological therapeutic effect was closely correlated to the rate of apoptosis. Thus, we suggest that HCR induces a therapeutic effect mainly through apoptosis in human rectal cancers.
- Published
- 1997