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1. Prediction of Isolated Local Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Nationwide Study

Author

van Goor, I. W. J. M., Andel, P. C. M., Buijs, F. S., Besselink, M. G., Bonsing, B. A., Bosscha, K., Busch, O. R., Cirkel, G. A., van Dam, R. M., Festen, S., Koerkamp, B. Groot, van der Harst, E., de Hingh, I. H. J. T., Kazemier, G., Liem, M. S. L., Meijer, G., de Meijer, V. E., Nieuwenhuijs, V. B., Roos, D., Schreinemakers, J. M. J., Stommel, M. W. J., Wit, F., Verdonk, R. C., van Santvoort, H. C., Molenaar, I. Q., Intven, M. P. W., and Daamen, L. A.

Published
2024
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6. Correction: Stereotactic ablative radiotherapy or best supportive care in patients with localized pancreatic cancer not receiving chemotherapy and surgery (PANCOSAR): a nationwide multicenter randomized controlled trial according to a TwiCs design

Author

Doppenberg, D., Besselink, M. G., van Eijck, C. H. J., Intven, M. P. W., Groot Koerkamp, B., Kazemier, G., van Laarhoven, H. W. M., Meijerink, M., Molenaar, I. Q., Nuyttens, J. J. M. E., van Os, R., van Santvoort, H. C., van Tienhoven, G., Verkooijen, H. M., Versteijne, E., Wilmink, J. W., Lagerwaard, F. J., and Bruynzeel, A. M. E.

Published
2023
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8. Cost-effectiveness of selective decontamination of the digestive tract to decrease infectious complications in colorectal cancer surgery: An analysis of the SELECT trial

Author

Abis, G.S.A., Bonjer, H.J., Tuynman, J.B., van Egmond, M., Stockmann, H.B.A.C., de Korte, N., Acherman, Y.I.Z., Oosterling, S.J., den Boer, F.C., Sonneveld, D.J.A., Budding, A.E., Poort, L., Reuvers, J.R.D., Gaikhorst, E., Ben, Â. Jornada, Scholten, J., Bosmans, J.E., and Kazemier, G.

Published
2023
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9. Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy

Author

Korenblik, R., Olij, B., Aldrighetti, L. A., Hilal, M. Abu, Ahle, M., Arslan, B., van Baardewijk, L. J., Baclija, I., Bent, C., Bertrand, C. L., Björnsson, B., de Boer, M. T., de Boer, S. W., Bokkers, R. P. H., Rinkes, I. H. M. Borel, Breitenstein, S., Bruijnen, R. C. G., Bruners, P., Büchler, M. W., Camacho, J. C., Cappelli, A., Carling, U., Chan, B. K. Y., Chang, D. H., choi, J., Font, J. Codina, Crawford, M., Croagh, D., Cugat, E., Davis, R., De Boo, D. W., De Cobelli, F., De Wispelaere, J. F., van Delden, O. M., Delle, M., Detry, O., Díaz-Nieto, R., Dili, A., Erdmann, J. I., Fisher, O., Fondevila, C., Fretland, Å., Borobia, F. Garcia, Gelabert, A., Gérard, L., Giuliante, F., Gobardhan, P. D., Gómez, F., Grünberger, T., Grünhagen, D. J., Guitart, J., Hagendoorn, J., Heil, J., Heise, D., Herrero, E., Hess, G. F., Hoffmann, M. H., Iezzi, R., Imani, F., Nguyen, J., Jovine, E., Kalff, J. C., Kazemier, G., Kingham, T. P., Kleeff, J., Kollmar, O., Leclercq, W. K. G., Ben, S. Lopez, Lucidi, V., MacDonald, A., Madoff, D. C., Manekeller, S., Martel, G., Mehrabi, A., Mehrzad, H., Meijerink, M. R., Menon, K., Metrakos, P., Meyer, C., Moelker, A., Modi, S., Montanari, N., Navines, J., Neumann, U. P., Peddu, P., Primrose, J. N., Qu, X., Raptis, D., Ratti, F., Ridouani, F., Rogan, C., Ronellenfitsch, U., Ryan, S., Sallemi, C., Moragues, J. Sampere, Sandström, P., Sarriá, L., Schnitzbauer, A., Serenari, M., Serrablo, A., Smits, M. L. J., Sparrelid, E., Spüntrup, E., Stavrou, G. A., Sutcliffe, R. P., Tancredi, I., Tasse, J. C., Udupa, V., Valenti, D., Fundora, Y., Vogl, T. J., Wang, X., White, S. A., Wohlgemuth, W. A., Yu, D., Zijlstra, I. A. J., Binkert, C. A., Bemelmans, M. H. A., van der Leij, C., Schadde, E., and van Dam, R. M.

Published
2022
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10. Impact of EUS-guided choledochoduodenostomy versus transpapillary endoscopic biliary drainage on the intra- and post-operative outcome of pancreatoduodenectomy: a multicenter propensity score matched study

Author

Fritzsche, J. A., additional, De Jong, M. J., additional, Bonsing, B. A., additional, Busch, O., additional, Daams, F., additional, Van Delft, F., additional, Derksen, W. J., additional, Erdmann, J. I., additional, Festen, S., additional, Fockens, P., additional, Van Geenen, E. M., additional, Inderson, A., additional, Kazemier, G., additional, Kuiken, S. D., additional, Liem, M. S., additional, Lips, D. J., additional, Te Riele, W., additional, Van Santvoort, H., additional, Siersema, P. D., additional, Venneman, N. G., additional, Verdonk, R., additional, Vleggaar, F., additional, Besselink, M., additional, van Wanrooij, R.L J, additional, and Voermans, R. P., additional

Published
2024
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14. Stereotactic ablative radiotherapy or best supportive care in patients with localized pancreatic cancer not receiving chemotherapy and surgery (PANCOSAR): a nationwide multicenter randomized controlled trial according to a TwiCs design

Author

Doppenberg, D., Besselink, M. G., van Eijck, C. H. J., Intven, M. P. W., Koerkamp, B. Groot, Kazemier, G., van Laarhoven, H. W. M., Meijerink, M., Molenaar, I. Q., Nuyttens, J. J. M. E., van Os, R., van Santvoort, H. C., van Tienhoven, G., Verkooijen, H. M., Versteijne, E., Wilmink, J. W., Lagerwaard, F. J., and Bruynzeel, A. M. E.

Published
2022
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15. Milt

Author

Kazemier, G., Zonderhuis, B. M., Heineman, E., editor, Heineman, D.J., editor, Lange jr., J.F.M., editor, Blankensteijn, J.D., editor, Boermeester, M.A., editor, Borel Rinkes, I.H.M., editor, Klaase, J.M., editor, Schipper, I.B., editor, Schreurs, W.H., editor, and Wijnen, R.M.H., editor

Published
2021
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16. Long-Term Quality of Life after Minimally Invasive vs Open Distal Pancreatectomy in the LEOPARD Randomized Trial

Author

van Santvoort, H.C., de Boer, M.T., Boerma, D., van den Boezem, P.B., van Dam, R.M., Dejong, C.H., van Duyn, E.B., van Eijck, C.H., Gerhards, M.F., de Hingh, I.H., Kazemier, G., de Kleine, R.H., van Laarhoven, C.J., Patijn, G.A., Steenvoorde, P., Suker, M., Hilal, M. Abu, Korrel, Maarten, Roelofs, Anne, van Hilst, Jony, Busch, Olivier R., Daams, Freek, Festen, Sebastiaan, Groot Koerkamp, Bas, Klaase, Joost, Luyer, Misha D., van Oijen, Martijn G., Verdonck-de Leeuw, Irma M., and Besselink, Marc G.

Published
2021
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18. Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study

Author

Andreou, A., Bartsch, F., Benzing, C., Buettner, S., Capobianco, I., Charco, R., de Reuver, P.R., de Savornin Lohman, E., Dejong, C.H.C., Efanov, M., Erdmann, J.I., Franken, L.C., Giglio, M.C., Gomez-Gavara, C., Hagendoorn, J., Heid, F., IJzermans, J.N.M., Kazemier, G., Maithel, S.K., Malago, M., Malik, H.Z., Molenaar, Q.I., Muiesan, P., Nooijen, L.E., Nota, C.L.M., Olde Damink, S.W.M., Pratschke, J., Quinn, L.M., Ratti, F., Ravaioli, M., Roberts, K.J., Rolinger, J., Ruzzenente, A., Schadde, E., Schmelzle, M., Serenari, M., Sultana, A., van Laarhoven, S., van Vugt, J.L.A., Zonderhuis, B.M., Jansson, Hannes, Olthof, Pim B., Bergquist, Annika, Ligthart, Marjolein A.P., Nadalin, Silvio, Troisi, Roberto I., Groot Koerkamp, Bas, Alikhanov, Ruslan, Lang, Hauke, Guglielmi, Alfredo, Cescon, Matteo, Jarnagin, William R., Aldrighetti, Luca, van Gulik, Thomas M., and Sparrelid, Ernesto

Published
2021
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20. Microscopic resection margin status in pancreatic ductal adenocarcinoma – A nationwide analysis

Author

Daamen, L.A., van Goor, I.W.J.M., Schouten, T.J., Dorland, G., van Roessel, S.R., Besselink, M.G., Bonsing, B.A., Bosscha, K., Brosens, L.A.A., Busch, O.R., van Dam, R.M., Fariña Sarasqueta, A., Festen, S., Groot Koerkamp, B., van der Harst, E., de Hingh, I.H.J.T., Intven, M.P.W., Kazemier, G., de Meijer, V.E., Nieuwenhuijs, V.B., Raicu, G.M., Roos, D., Schreinemakers, J.M.J., Stommel, M.W.J., van Velthuysen, M.F., Verheij, J., Verkooijen, H.M., van Santvoort, H.C., and Molenaar, I.Q.

Published
2021
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21. ASO Visual Abstract: Short- and Long-Term Outcomes of Pancreatic Cancer Resection for Elderly Patients: A Nationwide Analysis

Author

Henry, A. C., Schouten, T. J., Daamen, L. A., Walma, M. S., Noordzij, P., Cirkel, G. A., Los, M., Besselink, M. G., Busch, O. R., Bonsing, B. A., Bosscha, K., van Dam, R. M., Festen, S., Groot Koerkamp, B., van der Harst, E., de Hingh, I. H. J. T., Kazemier, G., Liem, M. S., de Meijer, V. E., Nieuwenhuijs, V. B., Roos, D., Schreinemakers, J. M. J., Stommel, M. W. J., Molenaar, I. Q., and van Santvoort, H. C.

Published
2022
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30. Pancreatectomy with arterial resection for periampullary cancer: outcomes after planned or unplanned events in a nationwide, multicentre cohort

Author

Stoop, T.F., Mackay, T.M., Brada, L.J.H., Harst, E. van der, Daams, F., Land, F.R. van 't, Kazemier, G., Patijn, G.A., Santvoort, H.C. van, Hingh, I.H. de, Bosscha, K., Seelen, L.W.F., Nijkamp, M.W., Stommel, M.W.J., Liem, M.S.L., Busch, O.R., Coene, P.P.L.O., Dam, R.M. van, Wilde, R.F. de, Mieog, J.S.D., Molenaar, I.Q., Besselink, M.G., Eijck, C.H.J. van, Dutch Pancreatic Canc Grp, Surgery, CCA - Cancer Treatment and quality of life, Amsterdam Gastroenterology Endocrinology Metabolism, AII - Cancer immunology, CCA - Cancer biology and immunology, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, Graduate School, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and CCA - Imaging and biomarkers

Subjects
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, Surgery
Abstract

Contains fulltext : 292877.pdf (Publisher’s version ) (Open Access)

Published
2023

32. Optimizing patient selection for stereotactic ablative radiotherapy in patients with locally advanced pancreatic cancer after initial chemotherapy - a single center prospective cohort

Author

Doppenberg, D., primary, Lagerwaard, F. J., additional, van Dieren, S., additional, Meijerink, M. R., additional, van der Vliet, J. J., additional, Besselink, M. G., additional, van Tienhoven, G., additional, Versteijne, E., additional, Slotman, B. J., additional, Wilmink, J. W., additional, Kazemier, G., additional, and Bruynzeel, A. M. E., additional

Published
2023
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34. Nationwide Validation of the 8th American Joint Committee on Cancer TNM Staging System and Five Proposed Modifications for Resected Pancreatic Cancer

Author

Schouten, T.J., Daamen, L.A., Dorland, G., Roessel, S.R. van, Groot, V.P., Besselink, M.G., Bonsing, B.A., Bosscha, K., Brosens, L.A.A., Busch, O.R., Dam, R.M. van, Sarasqueta, A.F., Festen, S., Koerkamp, B.G., Harst, E. van der, Hingh, I.H.J.T. de, Intven, M., Kazemier, G., Meijer, V.E. de, Nieuwenhuijs, V.B., Raicu, G.M., Roos, D., Schreinemakers, J.M.J., Stommel, M.W.J., Velthuysen, M.F. van, Verdonk, R.C., Verheij, J., Verkooijen, H.M., Santvoort, H.C. van, Molenaar, I.Q., Dutch Pancreatic Canc Grp, Surgery, Pathology, CCA - Imaging and biomarkers, Amsterdam Gastroenterology Endocrinology Metabolism, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: MA Heelkunde (9), Epidemiologie, Groningen Institute for Organ Transplantation (GIOT), and Center for Liver, Digestive and Metabolic Diseases (CLDM)

Subjects
EDITION, OUTCOMES, Survival, Ductal adenocarcinoma, SURGERY, Nodes, Number, Prognosis, United States, Pancreatic Neoplasms, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], All institutes and research themes of the Radboud University Medical Center, Oncology, SDG 3 - Good Health and Well-being, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], Humans, Prospective Studies, Carcinoma, Pancreatic Ductal, Neoplasm Staging
Abstract

Background The prognostic value of four proposed modifications to the 8th American Joint Committee on Cancer (AJCC) TNM staging system has yet to be evaluated. This study aimed to validate five proposed modifications. Methods Patients who underwent pancreatic ductal adenocarcinoma resection (2014–2016), as registered in the prospective Dutch Pancreatic Cancer Audit, were included. Stratification and prognostication of TNM staging systems were assessed using Kaplan–Meier curves, Cox proportional hazard analyses, and C-indices. A new modification was composed based on overall survival (OS). Results Overall, 750 patients with a median OS of 18 months (interquartile range 10–32) were included. The 8th edition had an increased discriminative ability compared with the 7th edition {C-index 0.59 (95% confidence interval [CI] 0.56–0.61) vs. 0.56 (95% CI 0.54–0.58)}. Although the 8th edition showed a stepwise decrease in OS with increasing stage, no differences could be demonstrated between all substages; stage IIA vs. IB (hazard ratio [HR] 1.30, 95% CI 0.80–2.09; p = 0.29) and stage IIB vs. IIA (HR 1.17, 95% CI 0.75–1.83; p = 0.48). The four modifications showed comparable prognostic accuracy (C-index 0.59–0.60); however, OS did not differ between all modified TNM stages (ns). The new modification, migrating T3N1 patients to stage III, showed a C-index of 0.59, but did detect significant survival differences between all TNM stages (p Conclusions The 8th TNM staging system still lacks prognostic value for some categories of patients, which was not clearly improved by four previously proposed modifications. The modification suggested in this study allows for better prognostication in patients with all stages of disease.

Published
2022

36. Somatostatin analogues for the prevention of pancreatic fistula after open pancreatoduodenectomy

Author

Bootsma, B.T., Plat, V.D., Brug, T. van de, Huisman, D.E., Botti, M., Boezem, P.B. van den, Bonsing, B.A., Bosscha, K., Dejong, C.H.C., Groot-Koerkamp, B., Hagendoorn, J., Harst, E. van der, Hingh, I.H. de, Meijer, V.E. de, Luyer, M.D., Nieuwenhuijs, V.B., Pranger, B.K., Santvoort, H.C. van, Wijsman, J.H., Zonderhuis, B.M., Kazemier, G., Besselink, M.G., Daams, F., Dutch Pancreatic Canc Grp, Groningen Institute for Organ Transplantation (GIOT), Center for Liver, Digestive and Metabolic Diseases (CLDM), Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, Plastic, Reconstructive and Hand Surgery, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and quality of life, Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer Treatment and Quality of Life, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
PROPHYLACTIC OCTREOTIDE, PHARMACOKINETICS, SURGERY, Endocrinology, Diabetes and Metabolism, INTERNATIONAL STUDY-GROUP, Somatostatin analogues, Octreotide, Pancreaticoduodenectomy, Pancreatic Fistula, Postoperative Complications, SDG 3 - Good Health and Well-being, Risk Factors, Humans, Pancreas, COMPLICATIONS, Hepatology, Pancreatoduodenectomy, Gastroenterology, Postoperative Pancreatic Fistula, Lanreotide, EFFICACY, CANCER, Pasireotide, RESECTIONS, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], DEFINITION, Somatostatin
Abstract

Contains fulltext : 251560.pdf (Publisher’s version ) (Open Access) BACKGROUND: Somatostatin analogues (SA) are currently used to prevent postoperative pancreatic fistula (POPF) development. However, its use is controversial. This study investigated the effect of different SA protocols on the incidence of POPF after pancreatoduodenectomy in a nationwide population. METHODS: All patients undergoing elective open pancreatoduodenectomy were included from the Dutch Pancreatic Cancer Audit (2014-2017). Patients were divided into six groups: no SA, octreotide, lanreotide, pasireotide, octreotide only in high-risk (HR) patients and lanreotide only in HR patients. Primary endpoint was POPF grade B/C. The updated alternative Fistula Risk Score was used to compare POPF rates across various risk scenarios. RESULTS: 1992 patients were included. Overall POPF rate was 13.1%. Lanreotide (10.0%), octreotide-HR (9.4%) and no protocol (12.7%) POPF rates were lower compared to the other protocols (varying from 15.1 to 19.1%, p = 0.001) in crude analysis. Sub-analysis in patients with HR of POPF showed a significantly lower rate of POPF when treated with lanreotide (10.0%) compared to no protocol, octreotide and pasireotide protocol (21.6-26.9%, p = 0.006). Octreotide-HR and lanreotide-HR protocol POPF rates were comparable to lanreotide protocol, however not significantly different from the other protocols. Multivariable regression analysis demonstrated lanreotide protocol to be positively associated with a low odds-ratio (OR) for POPF (OR 0.387, 95% CI 0.180-0.834, p = 0.015). In-hospital mortality rates were not affected. CONCLUSION: Use of lanreotide in all patients undergoing pancreatoduodenectomy has a potential protective effect on POPF development. Protocols for HR patients only might be favorable too. However, future studies are warranted to confirm these findings.

Published
2022

37. Impact of merging two university hospitals on surgical outcome after esophagogastric and hepato-pancreato-biliary surgery: Results from a retrospective study

Author

Ingwersen, E.W., primary, Stam, W.T., additional, van Kesteren, L.J., additional, Wissink, I.J.A., additional, van Berge Henegouwen, M.I., additional, Besselink, M.G., additional, Busch, O.R., additional, Erdmann, J.I., additional, Eshuis, W.J., additional, Gisbertz, S.S., additional, Kazemier, G., additional, van der Peet, D.L., additional, Swijnenburg, R.J., additional, Zonderhuis, B., additional, and Daams, F., additional

Published
2023
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40. First-line Systemic Treatment Strategies in Patients with Initially Unresectable Colorectal Liver Metastases: Phase III CAIRO5 Study of the Dutch Colorectal Cancer Group

Author

Bond, M.J., primary, Bolhuis, K., additional, Kazemier, G., additional, Klaase, J.M., additional, Liem, M.S., additional, Rijken, A.M., additional, Verhoef, C., additional, de Wilt, J.H., additional, Lopez-Yurda, M., additional, Punt, C.J., additional, and Swijnenburg, R.-J., additional

Published
2023
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43. Surgical Outcome After Pancreatoduodenectomy for Duodenal Adenocarcinoma Compared with Other Periampullary Cancers: A Nationwide Audit Study

Author

Bakker, J.K. de, Suurmeijer, J.A., Toennaer, J.G.J., Bonsing, B.A., Busch, O.R., Eijck, C.H.J. van, Hingh, I.H.J.T. de, Meijer, V.E. de, Molenaar, I.Q., Santvoort, H.C. van, Stommel, M.W.J., Festen, S., Harst, E, Patijn, G., Lips, D.J., Dulk, Marcel den, Bosscha, K., Besselink, M.G., and Kazemier, G.

Subjects
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], All institutes and research themes of the Radboud University Medical Center
Abstract

Contains fulltext : 291512.pdf (Publisher’s version ) (Open Access) BACKGROUND: Surgical outcome after pancreatoduodenectomy for duodenal adenocarcinoma could differ from pancreatoduodenectomy for other cancers, but large multicenter series are lacking. This study aimed to determine surgical outcome in patients after pancreatoduodenectomy for duodenal adenocarcinoma, compared with other periampullary cancers, in a nationwide multicenter cohort. METHODS: After pancreatoduodenectomy for cancer between 2014 and 2019, consecutive patients were included from the nationwide, mandatory Dutch Pancreatic Cancer Audit. Patients were stratified by diagnosis. Baseline, treatment characteristics, and postoperative outcome were compared between groups. The association between diagnosis and major complications (Clavien-Dindo grade III or higher) was assessed via multivariable regression analysis. RESULTS: Overall, 3113 patients, after pancreatoduodenectomy for cancer, were included in this study: 264 (8.5%) patients with duodenal adenocarcinomas and 2849 (91.5%) with other cancers. After pancreatoduodenectomy for duodenal adenocarcinoma, patients had higher rates of major complications (42.8% vs. 28.6%; p

Published
2023

46. ASO Visual Abstract: Surgical Outcome After Pancreatoduodenectomy for Duodenal Adenocarcinoma Compared with Other Periampullary Cancers-A Nationwide Audit Study

Author

Bakker, J.K. de, Annelie Suurmeijer, J., Toennaer, J.G.J., Bonsing, B.A., Busch, O.R., Eijck, C.H.J. van, Hingh, I.H.J.T. de, Meijer, V.E. de, Quintus Molenaar, I., Santvoort, H.C. van, Stommel, M.W.J., Festen, S., Harst, E.V., Patijn, G., Lips, D.J., Dulk, Marcel den, Bosscha, K., Besselink, M.G., and Kazemier, G.

Subjects
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], All institutes and research themes of the Radboud University Medical Center, Center for Biblical and Theological Studies (CBTS)
Abstract

Contains fulltext : 291514.pdf (Publisher’s version ) (Closed access) 01 april 2023

Published
2023

47. Lever, galblaas en galwegen

Author

Toorenvliet, B.R., Hamming, J.F., Kazemier, G., Schep, N.W.L., editor, van Grevenstein, W.M.U., editor, Heineman, D.J., editor, and Smeenk, H.G., editor

Published
2014
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48. Short- and Long-Term Outcomes of Pancreatic Cancer Resection in Elderly Patients: A Nationwide Analysis

Author

Henry, A.C., Schouten, T.J., Daamen, L.A., Walma, M.S., Noordzij, P., Cirkel, G.A., Los, M., Besselink, M.G.H., Busch, O.R., Bonsing, B.A., Bosscha, K., Dam, R.M. van, Festen, S., Koerkamp, B. Groot, Harst, E, Hingh, I. de, Kazemier, G., Liem, M.S., Meijer, V.E. de, Nieuwenhuijs, V.B., Roos, D., Schreinemakers, J.M.J., Stommel, M.W.J., Molenaar, I.Q., Santvoort, H.C. van, Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, CCA - Cancer Treatment and Quality of Life, Amsterdam Gastroenterology Endocrinology Metabolism, Groningen Institute for Organ Transplantation (GIOT), Center for Liver, Digestive and Metabolic Diseases (CLDM), and CCA - Cancer Treatment and quality of life

Subjects
CHRONIC KIDNEY-DISEASE, RISK, MORTALITY, OCTOGENARIANS, DUCTAL ADENOCARCINOMA, CHEMOTHERAPY, Pancreatic Hormones, Pancreatic Neoplasms, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Pancreatectomy, AGE, SDG 3 - Good Health and Well-being, Oncology, Chemotherapy, Adjuvant, PANCREATICODUODENECTOMY, Humans, Surgery, Prospective Studies, POSTOPERATIVE COMPLICATIONS, FRAILTY, Aged, Retrospective Studies
Abstract

Background The number of elderly patients with pancreatic cancer is growing, however clinical data on the short-term outcomes, rate of adjuvant chemotherapy, and survival in these patients are limited and we therefore performed a nationwide analysis. Methods Data from the prospective Dutch Pancreatic Cancer Audit were analyzed, including all patients undergoing pancreatic cancer resection between January 2014 and December 2016. Patients were classified into two age groups: Results Of 836 patients, 198 were aged ≥75 years (24%) and 638 were aged p = 0.43) and 90-day mortality (8% vs. 5%; p = 0.18) did not differ. Adjuvant chemotherapy was started in 37% of patients aged ≥75 years versus 69% of patients aged p < 0.001). Median overall survival (OS) was 15 months (95% confidence interval [CI] 14–18) versus 21 months (95% CI 19–24; p < 0.001). Age ≥75 years was not independently associated with OS (hazard ratio 0.96, 95% CI 0.79–1.17; p = 0.71), but was associated with a lower rate of adjuvant chemotherapy (odds ratio 0.27, 95% CI 0.18–0.40; p < 0.001). Conclusions The rate of major complications and 90-day mortality after pancreatic resection did not differ between elderly and younger patients; however, elderly patients were less often treated with adjuvant chemotherapy and their OS was shorter.

Published
2022

49. Ten-year outcomes of a randomised trial of laparoscopic versus open surgery for colon cancer

Author

Deijen, Charlotte L., Vasmel, Jeanine E., de Lange-de Klerk, Elly S. M., Cuesta, Miguel A., Coene, Peter-Paul L. O., Lange, Johan F., Meijerink, W. J. H. Jeroen, Jakimowicz, Jack J., Jeekel, Johannes, Kazemier, Geert, Janssen, Ignace M. C., Påhlman, Lars, Haglind, Eva, Bonjer, H. Jaap, Hellberg, R., Haglind, E., Kurlberg, G., Lindgren, P. G., Lindholm, E., Påhlman, L., Dahlberg, M., Raab, Y., Anderberg, B., Ewerth, S., Janson, M., Åkerlund, J. E., Smedh, K., Montgomery, A., Skullman, S., Nyström, P. O., Kald, A., Wänström, A., Dàlen, J., Svedberg, I., Edlund, G., Kressner, U., Öberg, A. N., Lundberg, O., Lindmark, G. E., Heikkinen, T., Morino, M., Giraudo, G., Lacy, A. M., Delgado, S., Macarulla Sanz, E., Díez, J. Medina, Schwandner, O., Schiedeck, T. H., Shekarriz, H., Bloechle, C., Baca, I., Weiss, O., Msika, S., Desvignes, G., Campbell, K. L., Cuschieri, A., Bonjer, H. J., Schouten, W. R., Kazemier, G., Lange, J. F., van der Harst, E., Coene, P. P. L. O., Plaisier, P., Bertleff, M. J. O. E., Cuesta, M. A., van der Broek, W., Meijerink, W. J. H. J., Jakimowicz, J. J., Nieuwenhuijzen, G., Maring, J., Kivit, J., Janssen, I. M. C., Spillenaar-Bilgen, E. J., Berends, F., and On behalf of the COLOR (COlon cancer Laparoscopic or Open Resection) study group

Published
2017
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50. Long-term quality of life and exocrine and endocrine insufficiency after pancreatic surgery: a multicenter, cross-sectional study

Author

Latenstein, A.E.J., Blonk, L., Tjahjadi, N.S., Jong, N. de, Busch, O.R., Hingh, I.H.J.T. de, Hooft, J.E. van, Liem, M.S.L., Molenaar, I.Q., Santvoort, H.C. van, Schueren, M.A.E. de van der, DeVries, J.H., Kazemier, G., Besselink, M.G., Dutch Pancreatic Canc Grp, Graduate School, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Surgery, Gastroenterology and Hepatology, APH - Health Behaviors & Chronic Diseases, Endocrinology, CCA - Cancer Treatment and quality of life, APH - Aging & Later Life, and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Pediatrics, medicine.medical_specialty, Cross-sectional study, Population, Disease, 030230 surgery, Pancreatic surgery, Pancreaticoduodenectomy, 03 medical and health sciences, 0302 clinical medicine, Pancreatectomy, Quality of life, Surveys and Questionnaires, medicine, Endocrine system, Humans, Life Science, education, Response rate (survey), Global Nutrition, education.field_of_study, Wereldvoeding, Hepatology, business.industry, Gastroenterology, Distress, Cross-Sectional Studies, 030220 oncology & carcinogenesis, Quality of Life, Exocrine Pancreatic Insufficiency, business
Abstract

Background: Data regarding long-term quality of life and exocrine and endocrine insufficiency after pancreatic surgery for premalignant and benign (non-pancreatitis) disease are lacking. Methods: This cross-sectional study included patients ≥3 years after pancreatoduodenectomy or left pancreatectomy in six Dutch centers (2006–2016). Outcomes were measured with the EQ-5D-5L, the EORTC QLQ-C30, an exocrine and endocrine pancreatic insufficiency questionnaire, and PAID20. Results: Questionnaires were completed by 153/183 patients (response rate 84%, median follow-up 6.3 years). Surgery related complaints were reported by 72/153 patients (47%) and 13 patients (8.4%) would not undergo this procedure again. The VAS (EQ-5D-5L) was 76 ± 17 versus 82 ± 0.4 in the general population (p < 0.001). The mean global health status (QLQ-C30) was 78 ± 17 versus 78 ± 17, p = 1.000. Fatigue, insomnia, and diarrhea were clinically relevantly worse in patients. Exocrine pancreatic insufficiency was reported by 62 patients (41%) with relieve of symptoms by enzyme supplementation in 48%. New-onset diabetes mellitus was present in 22 patients (14%). The median PAID20 score was 6.9/20 (IQR 2.5–17.8). Conclusion: Although generic quality of life after pancreatic resection for pre-malignant and benign disease was similar to the general population and diabetes-related distress was low, almost half suffered from a range of symptoms highlighting the need for long-term counseling.

Published
2021

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