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Introduction Barley is the fourth most important cereal in the world and is considered one of the least expected crops that has adapted and distributed globally due to its resistance to salinity. The growing world's population has expanded the cultivated domain, which caused the utilization of extravagant chemical fertilizers in modern agricultural cropping systems. This approach has not been cost-effective and has caused severe environmental damages like contaminating the underground water and creating unusual salinity in the fields. Therefore, it seems to be essential to replace risky approaches with eco-friendlier methods. In addition, with increasing environmental stress as a result of climate warming, we need to understand better ways to reduce environmental stress for the sustainable production of barley. Mycorrhiza has been introduced as an essential portion of agricultural ecosystems because of its positive effect on the soil texture, growth, and productivity of almost all host plants. This trend is attributed to reduced chemical fertilizer demands. Mycorrhiza enhances the water relations under stress conditions, water and nutrient uptake by augmenting the hyphae network. In this study we aimed to investigate the role of mycorrhizal inoculation in alleviating the detrimental effects of salinity stress on barley. Our hypotheses were: (i) mycorrhizal inoculation can alleviate the detrimental effect of stress at low to medium levels but not at high levels of salinity, and (ii) there is an interaction effect of low levels of salinity and arbuscular mycorrhizal symbiosis lead to higher the performance of barley. Materials and Methods In order to evaluate the effects of Funneliformis mosseae mycorrhiza on morphological, biochemical and yield of barley, one experiment was conducted in research farm of School of Agriculture, Shiraz University. Field experiment was a split-plot in a randomized complete block design with three replications. Factors included salinity levels (0.4, 4, 8 and 12 dS m-1) as the main factor and the mycorrhiza (with and without) was applied as sub factor. Data were analyzed by using SAS 9.2 software and the means were separated using LSD test at 5% probability level. Results and Discussion The results of the experiment showed that salinity decreased yield and vegetation traits, including plant height, number of tillers per plant, number of spikes per plant, number of seeds per spike, 1000-grain weight, grain yield, and biological yield. All the measured traits in plants inoculated with mycorrhizal fungi were higher than the non-mycorrhizal plants. The inoculation of plants in most cases improved the effects of stress; i.e., inoculation under high salinity stress (12 dS m-1) increased SOD by 5.7%, CAT by 8.0%, K concentration by 30.8%, K/Na ratio by 131.1%, plant height by 8.1%, number of spikes per plant by 9.4%, number of grain per spike by 6.6%, 1000-grain weight by 4.2%, grain yield by 20.2%, and biological yield by 11.0% compared with non-inoculation plants. Also, Fayaz and Zahedi (2021) reported that mycorrhizal inoculation could promote the growth and salt tolerance of wheat cultivars by improving osmoregulation and antioxidant enzyme activity and reducing the Na+/K+ ratio. Conclusion In this experiment, inoculation treatment alleviated the high salinity stress (12 dS m-1) effects in most cases and raised the grain yield and K+/Na+ ratio up to 20.2 and 131.1%, respectively, compared with non-inoculation plants. The results from this experiment showed that Funneliformis mosseae fungi inoculation could promote the growth and salt tolerance of barley by improving antioxidant enzyme activity, and ion homeostasis. In summary, the use of Funneliformis mosseae could reduce salinity damages by improving the physiological and biochemical responses of barley. This study highlighted the potential role of Funneliformis mosseae inoculation, in particular with native strains, as an innovative and eco-friendly technology for a sustainable crop-growing system in arid and semi-arid areas.

Abstract Glutathione S-transferase theta 1 (GSTT1) enzyme plays a key role in the neutralization of electrophilic compounds such as carcinogens. Herein, we aimed to evaluate GSTT1 deletion polymorphism and susceptibility to head and neck carcinoma (HNC) according to 107 articles in a systematic review with five analyses. The databases of PubMed/Medline, Web of Science, Scopus, and Cochrane Library from the beginning of each database until June 21, 2023, with no restrictions to identify pertinent articles. The RevMan 5.3 software was used to calculate the effect sizes, which were displayed as the odds ratio (OR) along with a 95% confidence interval (CI). Both the publication bias and sensitivity analyses were performed using the CMA 3.0 software. A trial sequential analysis (TSA) was conducted. Of the 1966 records retrieved from four databases, 107 articles were included in the analysis. The combined analysis revealed that the pooled OR was 1.28 (95% CI: 1.14 to 1.44; p-value

Background: Hemorrhoid is among the most common anorectal diseases and patients with high-grade disease conditions need surgical treatment. Many surgical procedures are available to treat the disease. The aim of this study was to compare the operative time and outcomes, (post-operative pain and complications) of LigaSure hemorrhoidectomy with those of the open conventional method.Methods : This randomized single-blind clinical trial included 57 patients (28 in LigaSure and 29 in the open group). The primary variable was the operative time for the excision of a single hemorrhoidal packet. The other variables were post-operative pain measured by morphine doses administered to control pain, scores of visual analogue scale (VAS) used to measure pain severity, pain during home stay measured by doses of oral ibuprofen and the mean daily VAS scores, early complications including bleeding and urinary retention, longer-term complications and time to return to work.Results : The demographic data were comparatively the same between the two groups. The average time to excise a single packet of hemorrhoid was significantly shorter in the LigaSure group (8.91 min vs. 17.35 min, P

"n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 st1":*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Polyethylene glycol (PEG) solution can induce complications when used as preoperative bowel preparation. The aim of this study was to compare two methods for mechanical bowel preparation in elective operations of colon."n"n Methods: In a randomized clinical trial, 129 patients elected for anastomosis of colon and referred to the surgical clinic of Imam Khomeini Hospital of Tehran between March 2008 and March 2009 were included. They were randomly allocated into two groups of PEG1 (1liter of PEG or 70gr plus 15 mg bizacodil, n=63) and PEG4 (4 liter of PEG), according to the way of bowel preparation; and on the day before surgery, they received oral and IV prophylactic antibiotics and cleared solutions. In the morning of the surgery, they received their medication during 240 minutes. Then, they underwent anastomosic surgery of colon. The principle variables recorded were nausea, vomiting, flatulence, Na and K in the night before surgery, patients' and surgeons' satisfaction from bowel preparation and postoperative infection and leakage. "n"nResults: The majority of the patients were male (62%). Nausea (28.57% vs. 98.48%, p=0.001), flatulence (36.51% vs. 95.45%, p=0.001), and vomiting (4.76% vs. 75.76%, p=0.001) were significantly lower in PEG1 and the patients' satisfaction were significantly higher (59.02% vs. 1.52%, p=0.001) Peroperative Na was significantly higher in PEG4 group (141.21±3.63 vs. 139.94±2.97mg/l, p=0.001) and serum K was significantly lower (3.55±0.25 vs. 3.76±0.21, p=0.001). Surgeons' satisfaction were significantly higher in PEG4 group (good to very good 72.73% vs. 43.54%, p=0.001). Postoperative infection of surgical site, anastomosis leakage and ICU admission were comparable between study groups. "n"nConclusions: Bowel preparation with 1 liter of PEG plus 3 bizacodile pills instead of 1 liter of PEG in patients undergoing elective anastomosis of colon is not only associated with lesser nausea, vomiting, flatulence, but also increases the patients' satisfaction and tolerance, lessens electrolyte disturbances and do not influence postoperative infection of surgical site and anastomosis leakage.

One of the ways to address the modern traffic-related problems is to encourage people to use sustainable travel modes more regularly. Transportation planners need to find the factors that affect people’s opinions toward using these modes. In this study, we investigated these factors using a case study of a developing country by distributing an online survey among the students of four universities in Tehran. The number of complete responses received was 134 from SUT, 63 for UT, 31 from AUT, and 204 from IUST, summing up to 432 responses. A binomial logistic regression model was used to find the paramount factors affecting the selection of cycling and public transportation. Our model found five and four statistically significant factors affecting preferences toward using bicycle and public transport, respectively. Several novel outcomes resulted from our study. First, expressing prestige to others resulted in the reduction of the preference of students toward cycling by 80%. Second, while a high number of the respondents are not currently using bikes to commute, a noticeable number of them are amongst the ones that will cycle in their daily commutes in an ideal condition. Third, in Iran, a religious approach is present in the society, which results in lower rates of public transport usage among females. Finally, while long commuting distance is the main barrier to cycling, travel time plays a bigger role in the preferences toward using public transportation. In the end, some practical solutions are suggested to encourage the usage of these modes. They include providing safe bicycle lanes and more space in the public transportation systems.

Abstract Background Continuous positive airway pressure (CPAP) is the mainstay of treatment for obstructive sleep apnea (OSA). However, data about its effect on the upper airway, especially the epiglottis, are scarce. The aim of this study was to investigate the changes in upper airway dimensions and inspiratory flow in response to incremental pressure levels. Methods This is a secondary analysis of a prospective clinical trial in which patients with moderate to severe OSA underwent drug-induced sleep endoscopy with simultaneous recordings of flow and mask pressure. CPAP was titrated in small increments. For each pressure level a representative 3-breath segment was selected to determine specific flow features. The corresponding endoscopic footage was reviewed to assess the degree of upper airway collapse in a semi-quantitative manner. Results A total of 214 breath segments were obtained from 13 participants (median [Q1–Q3]; apnea-hypopnea index, 24.9 [20.1–43.9] events/h; body mass index 28.1 [25.1–31.7] kg/m²). CPAP significantly increased cross-sectional dimensions of the soft palate, lateral walls and tongue base, but not of the epiglottis, and induced epiglottis collapse in one subject. Increased pressure improved peak inspiratory flow and median ventilation in all patients, even in the presence of persistent epiglottis collapse. Conclusion CPAP does not effectively address epiglottis collapse in patients with OSA. However, it normalizes inspiratory flow regardless of its effect on the epiglottis. This clinical trial was registered on January 18th, 2020 on ClinicalTrials.gov with identifier NCT04232410.

Abstract Introduction Colorectal cancer (CRC) surgery complications are a major issue affecting morbidity and mortality rates. Anastomotic stricture, which occurs in almost 30% of patients after surgery for rectal cancer, is one of the most serious but underreported side effects. In this study, we tried to assess the effect of stapler size on anastomotic stricture rate. Materials and Methods At our facility, all patients underwent low anterior resections (LAR) performed using an open laparotomy technique. A contour‐curved stapler and an end‐to‐end anastomosis (EEA) circular stapler were used in the double stapling technique (DST). All patients also underwent a protective loop ileostomy. Patients who developed stricture following leakage were excluded. Results This study comprised a total of 173 rectal cancer patients. A 29‐mm circle stapler was used to anastomose 77 patients (44.5%), while a 31‐mm circular stapler was used to anastomose 96 patients (55.5%). Six individuals experienced strictures; two had a 29 mm stamper and four (4.4%) had a 31 mm one. There was no significant difference between the two groups (p:0.575). On aggregate, 8 patients experienced leakage; 3 (3.8%) of these patients received treatment with a 29 mm stapler, whereas 5 (5.2%) received treatment with a 31 mm stapler. Conclusion this study found no statistically significant difference in the stricture rates and stapler size. The findings of this study provide credibility to the notion that in rectal cancer patients having LAR, strictures can be safely avoided by performing the anastomoses with both staplers.

Purpose: Bleeding is a leading cause of mortality and morbidity in the trauma and surgery field, using effective hemostatic agents can help us reduce bleeding especially in parenchymal hemorrhage. Nowadays polyvinyl alcohol (PVA) is known as a safe candidate for wound dressing and maybe a hemostatic agent. PVA-based hydrogel is a popular biocompatible material in the biomedical field especially when it has high water absorption. In this study, we investigated the PVA hydrogel’s mechanical and biological properties as well as its hemostatic potential in parenchymal bleeding. Methods: PVA hydrogel had made by the freeze-thawing approach, we used PVA hydrogel in comparison to standard treatment to investigate hemostatic potency. Also, we performed MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) tests to survey PVA cellular toxicity. After an acute liver injury, two groups of 12 rats were treated with PVA hydrogel or standard treatment with sterile gauze. The results including the time and volume of bleeding, and the time and survival rate of the rats were measured and compared. Results: We saw that PVA hydrogel was safe with no cellular toxicity in the MTT assay. Regarding efficacy, PVA hydrogel increased rats’ survival after bleeding from 75% to 91.7%, and decreased bleeding time ( p : 0.015), and bleeding volume ( p : 0.03) compared to the control group. Conclusion: Polyvinyl alcohol is safe. It has good biological properties with no cellular toxicity and has a significant hemostatic effect and can be regarded in control of parenchymal hemorrhage.