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Endometrial cancеr is the fourth fastеst-growing cancеr among women worldwide, affecting the uterus's lining. This research proposes a novel approach called ECgMLP for the automated diagnosis of endometrial cancer by analyzing histopathological images. Several preprocessing techniques are employed to increase the quality of the images, including normalization, Non-Local Means denoising, and alpha-beta enhancement. Effective segmentation is achieved through a combination of Otsu thresholding, morphological operations, distance transformations, and the watershed approach to identify major regions of interest. Through a sequence of blocks, the ECgMLP architecture processes input images to remove unimportant patterns. Model hyperparameters are improved via ablation research. The evaluations show a maximum accuracy of 99.26 % for identifying multi-class histopathological categories of endometrial tissue, which is higher than the previous best technique. The proposed model offers an automated, correct diagnosis, enhancing clinical processes. This proposition could be added to the current tools for finding endometrial cancer early, leading to better patient outcomes.

Convolutional neural networks (CNNs) have been established for a comprehensive range of computer vision problems across several benchmarks. Visualization and analysis of feature maps generated by convolutional layers can be an effective approach to explore the hidden and complex characteristic of a CNN model. Convolutional layers provide diverse feature maps however, the extent of this diversity needs to be explored. This research attempts to provide five insights of the ‘Black box’ mechanism of CNNs, using skin cancer dermoscopy and lung scan computed tomography (CT) Scan datasets by statistically analyzing layer by layer (three convolutional layers) feature maps using 17 geometrical and 6 intensity-based features to determine the characteristics and level of diversity. Significance and difference of the feature maps layer by layer, black feature maps analysis, difference of the feature maps to each other and to the original image, variations among the feature maps when running the model multiple times and inter-class variation among the feature maps for different iteration are explored. Various statistical methods including T-test, analysis of variance (ANOVA), mean, median, mean squared error (MSE), peak signal to noise ratio (PSNR), structural similarity index (SSIM), root mean squared error (RMSE), dice similarity score (DSC), universal image quality index (UQI) and Spectral angle mapper (SAM) are employed. Experimental results show that for the skin cancer dermoscopy dataset, a large number of black feature maps are produced (20–60%) while the proportion of black feature maps for the CT Scan dataset is comparatively low (2–20%). This demonstrates that for different datasets, feature maps with diverse characteristics can be produced. The layer by layer differences between the feature maps is evaluated using T-tests and ANOVA for seventeen geometrical features and six intensity-based features. For both datasets across most of the geometrical features and across most of the intensity-based features a significant diversity can be observed. The difference of the feature maps to each other and to the original image is quite high, with MSE values for the dermoscopy and CT Scan datasets in the range of 1860–31,399 and 171–6089, respectively, PSNR 3–15 and 10–25, SSIM values of 0.01–0.84 and 0.3–0.81, RMSE values of 0.81–1 and 0.21–1, DSC values of 0.37–0.53 and 0.47–0.75, UQI values of 0.02–0.86 and 0.01–0.88 and SAM values of 0.12–1.53 and 0.19–1.55 for the dermoscopy and CT Scan datasets respectively. When running the model multiple times (three iterations), a notable iteration by iteration diversity is found in terms of mean, median, maximum and minimum values for most of the geometrical features. The inter-class variation among the feature maps for different iterations and layers are evaluated based on the F-value of the ANOVA test. For the dermoscopy dataset, the highest mean F-value is found for layer 1 and iteration 3 while for the CT scan dataset the highest mean F-value is found for layer 3 and iteration 3 indicating that for these feature maps the highest inter-class dissimilarity is generated. The findings of this study may aid in exploring the complex mechanism of convolutional layers, kernels and feature maps.

Background: Breast cancer, behind skin cancer, is the second most frequent malignancy among women, initiated by an unregulated cell division in breast tissues. Although early mammogram screening and treatment result in decreased mortality, differentiating cancer cells from surrounding tissues are often fallible, resulting in fallacious diagnosis. Method: The mammography dataset is used to categorize breast cancer into four classes with low computational complexity, introducing a feature extraction-based approach with machine learning (ML) algorithms. After artefact removal and the preprocessing of the mammograms, the dataset is augmented with seven augmentation techniques. The region of interest (ROI) is extracted by employing several algorithms including a dynamic thresholding method. Sixteen geometrical features are extracted from the ROI while eleven ML algorithms are investigated with these features. Three ensemble models are generated from these ML models employing the stacking method where the first ensemble model is built by stacking ML models with an accuracy of over 90% and the accuracy thresholds for generating the rest of the ensemble models are >95% and >96. Five feature selection methods with fourteen configurations are applied to notch up the performance. Results: The Random Forest Importance algorithm, with a threshold of 0.045, produces 10 features that acquired the highest performance with 98.05% test accuracy by stacking Random Forest and XGB classifier, having a higher than >96% accuracy. Furthermore, with K-fold cross-validation, consistent performance is observed across all K values ranging from 3–30. Moreover, the proposed strategy combining image processing, feature extraction and ML has a proven high accuracy in classifying breast cancer.