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1. Stratification-Based Investigation of Adjunctive Brimonidine or Timolol to a Prostaglandin Analogue in Japanese Patients with Normal-Tension Glaucoma

Author: Yoshikawa K, Mizoue S, Nitta K, Onishi H, Ikeda M, Mizuno A, Kawazoe K, Tamada Y, Takeda R, and Matsumoto S
Subjects: adjunctive therapy, brimonidine, intraocular pressure reduction, post-hoc analysis, pulse rate, timolol, Ophthalmology, RE1-994
Abstract: Keiji Yoshikawa,1 Shiro Mizoue,2,3 Koji Nitta,4 Hiroshi Onishi,5 Masaharu Ikeda,5 Akemi Mizuno,5 Kaori Kawazoe,5 Yoshiyuki Tamada,5 Ryuji Takeda,6 Shun Matsumoto7 1Yoshikawa Eye Clinic, Tokyo, Japan; 2Ehime University Hospital, Toon, Ehime, Japan; 3Minami-Matsuyama Hospital, Matsuyama, Ehime, Japan; 4Fukui-ken Saiseikai Hospital, Fukui, Japan; 5Senju Pharmaceutical Co. Ltd., Hyogo, Japan; 6Kansai University of Welfare Sciences, Osaka, Japan; 7Ideta Eye Hospital, Kumamoto, JapanCorrespondence: Keiji YoshikawaYoshikawa Eye Clinic, 1-3-1 Nakamachi, Machida, Tokyo, 194-0021, JapanTel +81-42-739-0781Fax +81-42-739-0782Email mayokasyg51@galaxy.ocn.ne.jpPurpose: We previously investigated the efficacy and safety of adding 0.1% brimonidine (Brim) or 0.5% timolol (Tim) to prostaglandin analogue (PGA) monotherapy to treat patients with normal-tension glaucoma (NTG) with intraocular pressure (IOP) of ≤ 16 mmHg. Herein, we describe an additional post-hoc stratifying analysis of the possible differences in the effect of IOP-lowering and pulse rate (PR) after adjunctive Brim or Tim to PGA.Patients and Methods: This study included 128 subjects. Patients with NTG treated with PGA were stratified based on their baseline IOP. The changes in IOP from baseline and the effect of patient factors on IOP changes were investigated. Patients were stratified by age for investigation of their PR and blood pressure (BP). The change and the effect of patient factors on PR and BP were investigated.Results: After stratification analysis, in 52 eyes treated with Brim and 61 eyes with Tim with baseline IOP 12 ≤ IOP ≤ 16 mmHg, both eye drops lowered IOP significantly (P < 0.0001), and the IOP-lowering efficacy of Brim was non-inferior to that of Tim. However, in 9 Brim- and 6 Tim-treated eyes with baseline IOP of < 12 mmHg, no statistically significant decrease in IOP was evident with either eye drop. In the Tim group, PR decreased significantly (P < 0.05) after stratification by age.Conclusion: The IOP-lowering efficacy of Brim was non-inferior to that of Tim after stratification by baseline IOP (12 ≤ IOP ≤ 16 mmHg). The discrepancy in the IOP-lowering effects of Brim and Tim observed in the previous study was thought to be related to enrolled subjects with low baseline IOP. PR decreased significantly in the Tim group even after age stratification. PR should be considered when selecting β-blockers for glaucoma treatment.Keywords: adjunctive therapy, brimonidine, intraocular pressure reduction, post-hoc analysis, pulse rate, timolol
Published: 2021

2. Evaluation of effects of various drugs on platelet functions using phorbol 12-myristate 13-acetate-induced megakaryocytic human erythroid leukemia cells

Author: Tada T, Aki K, Oboshi W, Kawazoe K, Yasui T, and Hosoi E
Subjects: platelets, intracellular Ca2+ concentration ([Ca2+]i), aspirin, cilostazol, ibuprofen, sodium valproate, Therapeutics. Pharmacology, RM1-950
Abstract: Tomoki Tada,1 Kensaku Aki,2 Wataru Oboshi,1,3 Kazuyoshi Kawazoe,4 Toshiyuki Yasui,5 Eiji Hosoi2 1Subdivision of Biomedical Laboratory Sciences, Graduate School of Health Sciences, Tokushima University, 2Department of Cells and Immunity Analytics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 3Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Kagawa, 4Department of Clinical Pharmacy Practice Pedagogy, Institute of Biomedical Sciences, 5Department of Reproductive and Menopausal Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan Background: The hyperfunction and activation of platelets have been strongly implicated in the development and recurrence of arterial occlusive disease, and various antiplatelet drugs are used to treat and prevent such diseases. New antiplatelet drugs and many other drugs have been developed, but some drugs may have adverse effects on platelet functions. Objective: The aim of this study was to establish an evaluation method for evaluating the effect and adverse effect of various drugs on platelet functions. Materials and methods: Human erythroid leukemia (HEL) cells were used after megakaryocytic differentiation with phorbol 12-myristate 13-acetate as an alternative to platelets. Drugs were evaluated by changes in intracellular Ca2+ concentration ([Ca2+]i) mobilization in Fura2-loaded phorbol 12-myristate 13-acetate-induced HEL cells. Aspirin and cilostazol were selected as antiplatelet drugs and ibuprofen and sodium valproate as other drugs. Results: There was a positive correlation between [Ca2+]i and platelet aggregation induced by thrombin. Aspirin (5.6–560 µM) and cilostazol (5–10 µM) significantly inhibited thrombin-induced increases in [Ca2+]i in a concentration-dependent manner. On the other hand, ibuprofen (8–200 µM) and sodium valproate (50–1,000 µg/mL) also significantly inhibited thrombin-induced increases in [Ca2+]i in a concentration-dependent manner. Furthermore, the interaction effects of the simultaneous combined use of aspirin and ibuprofen or sodium valproate were evaluated. When the inhibitory effect of aspirin was higher than that of ibuprofen, the effect of aspirin was reduced, whereas when the inhibitory effect of aspirin was lower than that of ibuprofen, the effect of ibuprofen was reduced. The combination of aspirin and sodium valproate synergistically inhibited thrombin-induced [Ca2+]i. Conclusion: It is possible to induce HEL cells to differentiate into megakaryocytes, which are a useful model for the study of platelet functions, and the quantification of the inhibition of thrombin-induced increases in [Ca2+]i is applicable to the evaluation of the effects of various drugs on platelets. Keywords: platelets, intracellular Ca2+ concentration ([Ca2+]i), aspirin, cilostazol, ibuprofen, sodium valproate
Published: 2016

3. Open data from the third observing run of LIGO, Virgo, KAGRA and GEO

Author: The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abe, H., Acernese, F., Ackley, K., Adhicary, S., Adhikari, N., Adhikari, R. X., Adkins, V. K., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Albanesi, S., Alfaidi, R. A., Al-Jodah, A., Alléné, C., Allocca, A., Almualla, M., Altin, P. A., Amato, A., Amez-Droz, L., Amorosi, A., Anand, S., Ananyeva, A., Andersen, R., Anderson, S. B., Anderson, W. G., Andia, M., Ando, M., Andrade, T., Andres, N., Andrés-Carcasona, M., Andrić, T., Ansoldi, S., Antelis, J. M., Antier, S., Aoumi, M., Apostolatos, T., Appavuravther, E. Z., Appert, S., Apple, S. K., Arai, K., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Arogeti, M., Aronson, S. M., Arun, K. G., Asada, H., Ashton, G., Aso, Y., Assiduo, M., Melo, S. Assis de Souza, Aston, S. M., Astone, P., Aubin, F., AultONeal, K., Babak, S., Badalyan, A., Badaracco, F., Badger, C., Bae, S., Bagnasco, S., Bai, Y., Baier, J. G., Baiotti, L., Baird, J., Bajpai, R., Baka, T., Ball, M., Ballardin, G., Ballmer, S. W., Baltus, G., Banagiri, S., Banerjee, B., Bankar, D., Baral, P., Barayoga, J. C., Barber, J., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Barthelmy, S. D., Barton, M. A., Bartos, I., Basak, S., Basalaev, A., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Beirnaert, F., Bejger, M., Bell, A. S., Benedetto, V., Beniwal, D., Benoit, W., Bentley, J. D., Yaala, M. Ben, Bera, S., Berbel, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Beroiz, M., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bevins, N., Bhandare, R., Bhandari, A. V., Bhardwaj, U., Bhatt, R., Bhattacharjee, D., Bhaumik, S., Bianchi, A., Bilenko, I. A., Bilicki, M., Billingsley, G., Bini, S., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boër, M., Bogaert, G., Boileau, G., Boldrini, M., Bolingbroke, G. N., Bonavena, L. D., Bondarescu, R., Bondu, F., Bonilla, E., Bonilla, G. S., Bonnand, R., Booker, P., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Braglia, M., Branch, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bucci, F., Buchanan, J., Bulashenko, O., Bulik, T., Bulten, H. J., Buonanno, A., Burtnyk, K., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Davies, G. S. Cabourn, Cabras, G., Cabrita, R., Cadonati, L., Caesar, S., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Santoro, G. Caneva, Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, Z., Capistran, L. A., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlassara, M., Carlin, J. B., Carpinelli, M., Carter, J. J., Carullo, G., Diaz, J. Casanueva, Casentini, C., Castaldi, G., Castro-Lucas, S. Y., Caudill, S., Cavaglià, M., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakalis, W., Subrahmanya, S. Chalathadka, Champion, E., Chan, C., Chan, C. L., Chandra, K., Chang, I. P., Chang, W., Chanial, P., Chao, S., Chapman-Bird, C., Charlton, E. L., Charlton, P., Chassande-Mottin, E., Chastain, L., Chatterjee, C., Chatterjee, Debarati, Chatterjee, Deep, Chaturvedi, M., Chaty, S., Chatziioannou, K., Chen, D., Chen, H., Chen, H. Y., Chen, J., Chen, K. H., Chen, X., Chen, Y. -R., Chen, Y., Cheng, H., Chessa, P., Cheung, H. Y., Chia, H. Y., Chiadini, F., Chiang, C-I., Chiang, C., Chiarini, G., Chiba, A., Chiba, R., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Choudhary, S., Christensen, N., Chua, S. S. Y., Chung, K. W., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., Ciolfi, R., Clara, F., Clark, J. A., Clarke, T. A., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Codazzo, E., Cohadon, P. -F., Colleoni, M., Collette, C. G., Colombo, A., Colpi, M., Compton, C. M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Cornish, N. J., Corsi, A., Cortese, S., Coschizza, A. C., Cottingham, R., Coughlin, M. W., Coulon, J. -P., Countryman, S. T., Coupechoux, J. -F., Cousins, B., Couvares, P., Coward, D. M., Cowart, M. J., Cowburn, B. D., Coyne, D. C., Coyne, R., Craig, K., Creighton, J. D. E., Creighton, T. D., Criswell, A. W., Crockett-Gray, J. C. G., Croquette, M., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cummings, R., Cuoco, E., Curyło, M., Dabadie, P., Canton, T. Dal, Dall'Osso, S., Dálya, G., D'Angelo, B., Danilishin, S., D'Antonio, S., Danzmann, K., Darroch, K. E., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Datta, Sayantani, Dattilo, V., Dave, I., Davenport, A., Davier, M., Davis, D., Davis, M. C., Daw, E. J., Dax, M., DeBra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., De Lillo, N., Dell'Aquila, D., Del Pozzo, W., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., De Simone, R., Dhurandhar, S., Diab, R., Diamond, P. Z., Díaz, M. C., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Diksha, D., Di Lieto, A., Di Michele, A., Di Pace, S., Di Palma, I., Di Renzo, F., Divyajyoti, Dmitriev, A., Doctor, Z., Dohmen, E., Doleva, P. P., Donahue, L., D'Onofrio, L., Donovan, F., Dooley, K. L., Dooney, T., Doravari, S., Dorosh, O., Drago, M., Driggers, J. C., Drori, Y., Ducoin, J. -G., Dunn, L., Dupletsa, U., Durante, O., D'Urso, D., Duverne, P. -A., Dwyer, S. E., Eassa, C., Easter, P. J., Ebersold, M., Eckhardt, T., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eichholz, J., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Engelby, E., Engl, A. J., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etzel, T., Evans, C., Evans, M., Evans, T. M., Evstafyeva, T., Ewing, B. E., Fabrizi, F., Faedi, F., Fafone, V., Fair, H., Fairhurst, S., Fan, P. C., Fan, X., Farah, A. M., Farr, B., Farr, W. M., Fauchon-Jones, E. J., Favaro, G., Favata, M., Fays, M., Feicht, J., Fejer, M. M., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, A., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Fleischer, S. M., Fleming, L. S., Floden, E., Fong, H. K., Font, J. A., Fornal, B., Forsyth, P. W. F., Franke, A., Frasca, S., Frasconi, F., Freed, J. P., Frei, Z., Freise, A., Freitas, O., Frey, R., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fujimoto, Y., Fukunaga, I., Fulda, P., Fyffe, M., Gabbard, H. A., Gabella, W. E., Gadre, B. U., Gaglani, K., Gair, J. R., Gais, J., Galaudage, S., Gallardo, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D., Gaonkar, S. G., Garaventa, B., Garcia-Bellido, J., García-Núñez, C., García-Quirós, C., Gardner, K. A., Gargiulo, J., Garufi, F., Gasbarra, C., Gateley, B., Gayathri, V., Gemme, G., Gennai, A., George, J., Gerberding, O., Gergely, L., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, Shaon, Ghosh, Shrobana, Ghosh, Tathagata, Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Giri, P., Gissi, F., Gkaitatzis, S., Glanzer, J., Gleckl, A. E., Glotin, F., Godfrey, J., Godwin, P., Goetz, E., Goetz, R., Golomb, J., Goncharov, B., González, G., Gosselin, M., Gouaty, R., Gould, D. W., Goyal, S., Grace, B., Grado, A., Graham, V., Granata, M., Granata, V., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Green, S., Green, S. R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W. L., Griggs, H. L., Grignani, G., Grimaldi, A., Grote, H., Gruson, A. S., Guerra, D., Guetta, D., Guidi, G. M., Guimaraes, A. R., Gulati, H. K., Gulminelli, F., Gunny, A. M., Guo, H., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, Ish, Gupta, N. C., Gupta, P., Gupta, S. K., Gurs, J., Gushima, Y., Gustafson, E. K., Gutierrez, N., Guzman, F., Haegel, L., Hain, G., Haino, S., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Han, W. -B., Haney, M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hansen, H., Hanson, J., Harada, R., Harder, T., Haris, K., Harmark, T., Harms, J., Harry, G. M., Harry, I. W., Hartwig, D., Haskell, B., Haster, C. -J., Hathaway, J. S., Haughian, K., Hayakawa, H., Hayama, K., Hayes, F. J., Healy, J., Heffernan, A., Heidmann, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J. -S., Hennig, M., Henshaw, C., Vivanco, F. Hernandez, Heurs, M., Hewitt, A. L., Higginbotham, S., Hild, S., Hill, P., Himemoto, Y., Hines, A. S., Hirata, N., Hirose, C., Ho, J., Hochheim, S., Hofman, D., Hohmann, J. N., Holcomb, D. G., Holland, N. A., Holley-Bockelmann, K., Hollows, I. J., Holmes, Z. J., Holt, K., Holz, D. E., Hong, Q., Hornung, J., Hoshino, S., Hough, J., Hourihane, S., Howell, D., Howell, E. J., Hoy, C. G., Hoyland, D., Hsieh, B. -H., Hsieh, H. -F., Hsiung, C., Hsu, H., Hu, P., Hu, Q., Huang, H. -Y., Huang, Y. -J., Huang, Y., Huang, Y. T., Hübner, M. T., Huddart, A. D., Hughey, B., Hui, D. C. Y., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Hyland, J., Iakovlev, A., Iandolo, G. A., Idzkowski, B., Iess, A., Inayoshi, K., Inoue, Y., Iorio, G., Iosif, P., Irwin, J., Isi, M., Ismail, M. A., Itoh, Y., Iyer, B. R., JaberianHamedan, V., Jacqmin, T., Jacquet, P. -E., Jadhav, S. J., Jadhav, S. P., Jain, D., Jain, T., James, A. L., Jan, A. Z., Jani, K., Janiurek, L., Janquart, J., Janssens, K., Janthalur, N. N., Jaraba, S., Jaranowski, P., Jarov, S., Jasal, P., Jaume, R., Javed, W., Jenkins, A. C., Jenner, K., Jennings, A., Jia, W., Jiang, J., Liu, Jian, Jin, H. -B., Johansmeyer, K., Johns, G. R., Johnson, N. A., Johnston, R., Johny, N., Jones, A. W., Jones, D. H., Jones, D. I., Jones, P., Jones, R., Joshi, P., Ju, L., Jung, K., Junker, J., Juste, V., Kajita, T., Kalaghatgi, C., Kalogera, V., Kamai, B., Kamiizumi, M., Kanda, N., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Kapasi, D. P., Karat, S., Karathanasis, C., Karki, S., Kasamatsu, D., Kas-danouche, Y. A., Kashyap, R., Kasprzack, M., Kastaun, W., Kato, J., Katsanevas, S., Katsavounidis, E., Katsuren, J. K., Katzman, W., Kaur, T., Kawabe, K., Kawazoe, K., Kéfélian, F., Keitel, D., Kellard, I., Kelley-Derzon, J., Kennington, J., Key, J. S., Khadka, S., Khalili, F. Y., Khan, S., Khanam, T., Khazanov, E. A., Khursheed, M., Kijbunchoo, N., Kim, C., Kim, J. C., Kim, K., Kim, M. H., Kim, P., Kim, S., Kim, W. S., Kim, Y. -M., Kimball, C., Kimura, N., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kiyota, T., Klimenko, S., Klinger, T., Knee, A. M., Knust, N., Kobayashi, Y., Koch, P., Koehlenbeck, S. M., Koekoek, G., Kohri, K., Kokeyama, K., Koley, S., Koliadko, N. D., Kolitsidou, P., Kolstein, M., Kondrashov, V., Kong, A. K. H., Kontos, A., Korobko, M., Kossak, R. V., Kouvatsos, N., Kovalam, M., Koyama, N., Kozak, D. B., Kranzhoff, L., Kranzhoff, S. L., Kringel, V., Krishnendu, N. V., Królak, A., Kuehn, G., Kuijer, P., Kukihara, M., Kulkarni, S., Kumar, A., Kumar, Praveen, Kumar, Prayush, Kumar, Rahul, Kumar, Rakesh, Kume, J., Kuns, K., Kuroyanagi, S., Kuwahara, S., Kwak, K., Lacaille, G., Lagabbe, P., Laghi, D., Lakkis, M. H., Lalande, E., Lalleman, M., Lamberts, A., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., La Rana, A., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Lawrence, J., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., LeBohec, S., Lecoeuche, Y. K., Lee, E., Lee, H. M., Lee, H. W., Lee, K., Lee, R. -L., Lee, R., Lee, S., Legred, I. N., Lehmann, J., Lehner, L., Lemaître, A., Lenti, M., Leonardi, M., Leonova, E., Leroy, N., Letendre, N., Lethuillier, M., Levesque, C., Levin, Y., Leyde, K., Li, A. K. Y., Li, K. L., Li, T. G. F., Li, X., Lin, C. -Y., Lin, E. T., Lin, F-K., Lin, F-L., Lin, F., Lin, H. L., Lin, H., Lin, L. C. -C., Linde, F., Linker, S. D., Littenberg, T. B., Liu, A., Liu, G. C., Llamas, F., Lo, R. K. L., Lo, T., London, L. T., Longo, A., Lopez, D., Portilla, M. Lopez, Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lott, T. P., Lough, J. D., Loughlin, H. A., Lousto, C. O., Lovelace, G., Lowry, M. J., Lück, H., Lumaca, D., Lundgren, A. P., Lung, Y., Lussier, A. W., Lynam, J. E., Ma, L., Ma, S., Ma'arif, M., Macas, R., MacInnis, M., Macleod, D. M., MacMillan, I. A. O., Macquet, A., Hernandez, I. Magaña, Magazzù, C., Magee, R. M., Maggiore, R., Magnozzi, M., Mahesh, M., Mahesh, S., Maini, M., Majorana, E., Makarem, C. N., Maliakal, S., Malik, A., Man, N., Mandic, V., Mangano, V., Mannix, B., Mansell, G. L., Mansingh, G., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Pina, D. Marín, Marion, F., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, B. B., Martinez, M., Martinez, V. A., Martinez, V., Martinovic, K., Martynov, D. V., Marx, E. J., Masalehdan, H., Mason, K., Masserot, A., Reid, M. Masso, Mastrodicasa, M., Mastrogiovanni, S., Mateu-Lucena, M., Matiushechkina, M., Matsunaga, K., Mavalvala, N., McCarthy, R., McClelland, D. E., McClincy, P. K., McCormick, S., McCuller, L., McGhee, G. I., McGinn, J., McIsaac, C., McIver, J., McLeod, A., McRae, T., McWilliams, S. T., Meacher, D., Mehmet, M., Mehta, A. K., Meijer, Q., Melatos, A., Mendell, G., Menendez-Vazquez, A., Menoni, C. S., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Merritt, J. D., Merzougui, M., Messenger, C., Messick, C., Meyers, P. M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Michimura, Y., Middleton, H., Mihaylov, D. P., Miller, A., Miller, A. L., Miller, B., Miller, S., Millhouse, M., Mills, J. C., Milotti, E., Minenkov, Y., Mio, N., Mir, Ll. M., Miravet-Tenés, M., Mishra, A., Mishra, C., Mishra, T., Mistry, T., Mitchell, A. L., Mitra, S., Mitrofanov, V. 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S., Wilken, D., Willetts, K., Williams, D., Williams, M. J., Williamson, A. R., Willis, J. L., Willke, B., Wipf, C. C., Woan, G., Woehler, J., Wofford, J. K., Wong, D., Wong, H. T., Wong, I. C. F., Wright, M., Wu, C., Wu, D. S., Wu, H., Wysocki, D. M., Xiao, L., Xu, V. A., Yadav, N., Yamada, T., Yamamoto, H., Yamamoto, K., Yamamoto, M., Yamamoto, T., Yamamoto, T. S., Yamashita, K., Yamazaki, R., Yang, F. W., Yang, K. Z., Yang, Y. -C., Yap, M. J., Yeeles, D. W., Yelikar, A. B., Yeung, T. Y., Yokoyama, J., Yokozawa, T., Yoo, J., Yu, Hang, Yu, Haocun, Yuzurihara, H., Zadrożny, A., Zannelli, A. J., Zanolin, M., Zeeshan, M., Zeidler, S., Zelenova, T., Zendri, J. -P., Zevin, M., Zhang, J., Zhang, L., Zhang, R., Zhang, T., Zhang, Y., Zhao, C., Zhao, Yue, Zhao, Yuhang, Zheng, Y., Zhong, H., Zhou, R., Zhu, X. J., Zhu, Z. -H., Zimmerman, A. B., Zucker, M. E., and Zweizig, J.
Subjects: General Relativity and Quantum Cosmology
Abstract: The global network of gravitational-wave observatories now includes five detectors, namely LIGO Hanford, LIGO Livingston, Virgo, KAGRA, and GEO 600. These detectors collected data during their third observing run, O3, composed of three phases: O3a starting in April of 2019 and lasting six months, O3b starting in November of 2019 and lasting five months, and O3GK starting in April of 2020 and lasting 2 weeks. In this paper we describe these data and various other science products that can be freely accessed through the Gravitational Wave Open Science Center at https://gwosc.org. The main dataset, consisting of the gravitational-wave strain time series that contains the astrophysical signals, is released together with supporting data useful for their analysis and documentation, tutorials, as well as analysis software packages., Comment: 27 pages, 3 figures
Published: 2023
Full Text: View/download PDF

4. Evaluation of effects of various drugs on platelet functions using phorbol 12-myristate 13-acetate-induced megakaryocytic human erythroid leukemia cells [Corrigendum]

Author: Tada T, Aki K, Oboshi W, Kawazoe K, Yasui T, and Hosoi E
Subjects: Therapeutics. Pharmacology, RM1-950
Abstract: Tada T, Aki K, Oboshi W, Kawazoe K, Yasui T, Hosoi E. Drug Des Devel Ther. 2016;10:3099–3107. In page 3103, there is an error in Figure 3B:Read the original article
Published: 2017

5. Evaluation of a partial retinal surface tear by optical coherence tomography

Author: Kawazoe K, Ohno H, Inoue K, and Yanagi Y
Subjects: Ophthalmology, RE1-994
Abstract: Kenji Kawazoe1, Hisato Ohno1, Kenji Inoue1, Yasuo Yanagi21Inouye Eye Hospital, 4-3 Kanda-Surugadai, Chiyoda-ku, Tokyo, Japan; 2Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1 Hongo Bunkyo-ku, Tokyo, JapanAbstract: Differential diagnosis of retinal hemorrhage and partial tear of the retinal surface may be difficult in some cases. A 62-year-old woman was mistakenly followed-up for small retinal hemorrhages for more than 1 year. Blocked fluorescence specific to retinal hemorrhage was not observed by fluorescein angiography (FAG). Optical coherence tomography (OCT) clearly showed defects of the retinal surface indicating partial tears of the surface at the vitreoretinal juncture and not hemorrhage. OCT is a useful and noninvasive device for the differential diagnosis of retinal hemorrhage and partial tear of the retinal surface.Keywords: OCT, differential diagnosis, retinal surface defect,vitreoretinal juncture over retinal vessels
Published: 2011

6. Ministry of health and welfare study for the ATS medical bileaflet valve in Japan

Author: Shiono, Motomi, Sezai, Y., Sezai, A., Omoto, R., Kyo, S., Hatanaka, M., Kitamura, S., Kawachi, K., Hasegawa, J., Kawazoe, K., Sasaki, T., Krian, Arno, editor, Matloff, J. M., editor, and Nicoloff, D. M., editor
Published: 1998
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7. Penetration of Fluconazole into Gynaecological Tissues

Author: Mikamo, H., Kawazoe, K., Izumi, K., Ito, K., Yamada, Y., and Tamaya, T.
Published: 1995
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8. Vibration control of plates by plate-type dynamic vibration absorbers

Author: Aida, T., Kawazoe, K., and Toda, S.
Subjects: Vibration -- Control, Plates (Engineering) -- Research, Damping (Mechanics) -- Equipment and supplies, Science and technology
Published: 1995

9. Juvenile fulminant adnexal tuberculosis caused by gastrointestinal tuberculosis immediately after ovarian cystectomy

Author: Mikamo, H., Yasuda-Kawazoe, K., Sato, Y., Hayasaki, Y., Hua, Y. X., and Tamaya, T.
Published: 2000
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10. Identification of growth hormone receptor in the ovary of tilapia, Oreochromis mossambicus

Author: Kajimura, S., Kawaguchi, N., Kawazoe, K., Okubo, K., and Aida, K.
Published: 2003

11. Dynamics of Flying Head Slider for Grooved Discrete Track Disk

Author: Kawazoe, K., primary, Yotsuya, M., additional, Shimamura, T., additional, and Okada, K., additional
Published: 1995
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12. Non-steady characteristics of dispersion and ignitability for high-pressurized hydrogen jet discharged from a pinhole

Author: Okabayashi, K., primary, Tagashira, K., additional, Kawazoe, K., additional, Takeno, K., additional, Asahara, M., additional, Hayashi, A.K., additional, and Komori, M., additional
Published: 2019
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13. Hippocampal neuronal death following deep hypothermic circulatory arrest in dogs: involvement of apoptosis

Author: Kin, H, Ishibashi, K, Nitatori, T, and Kawazoe, K
Published: 1999
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14. Primary Tissue Failure in Porcine Aortic and Bovine Pericardial Bioprostheses

Author: Kawazoe, K., Fujita, T., Yamamoto, F., Takeuchi, S., Fujii, N., Manabe, H., Gomez-Duran, Carlos, editor, and Reul, George J., Jr., editor
Published: 1989
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15. Observing gravitational-wave transient GW150914 with minimal assumptions

Author: Abbott, B. P., Abbott, Abbott, R., Abernathy, T. D., Acernese, M. R., Ackley, F., Adams, K., Adams, C., Addesso, T., Adhikari, P., Adya, R. X., Affeldt, V. B., Agathos, C., Agatsuma, M., Aggarwal, K., Aguiar, N., Aiello, O. D., Ain, L., Ajith, A., Allen, P., Allocca, B., Altin, A., Anderson, P. A., Anderson, S. B., Arai, W. G., Araya, K., Arceneaux, M. C., Areeda, C. C., Arnaud, J. S., Arun, N., Ascenzi, K. G., Ashton, S., Ast, G., Aston, M., Astone, S. M., Aufmuth, P., Aulbert, P., Babak, C., Bacon, S., Bader, P., Baker, M. K. M., And, P. T., Baldaccini, Francesca, Ballardin, And, Ballmer, G., Barayoga, S. W., Barclay, J. C., Barish, S. E., Barker, B. C., Barone, D., Barr, F., Barsotti, B., Barsuglia, L., Barta, M., Bartlett, D., Bartos, J., Bassiri, I., Basti, R., Batch, A., Baune, J. C., Bavigadda, C., Bazzan, V., Behnke, M., Bejger, B., Bell, M., Bell, A. S., Berger, C. J., Bergman, B. K., Bergmann, J., Berry, G., Bersanetti, C. P. L., Bertolini, D., Betzwieser, A., Bhagwat, J., Bhandare, S., Bilenko, R., Billingsley, I. A., Birch, G., Birney, J., Biscans, R., Bisht, S., Bitossi, A., Biwer, M., Bizouard, C., Blackburn, M. A., Blackburn, J. K., Blair, L., Blair, C. D., Blair, D. G., Bloemen, R. M., Bock, S., Bodiya, O., Boer, T. P., Bogaert, M., Bogan, G., Bohe, C., Bojtos, A., Bond, P., Bondu, C., Bonnand, F., Boom, R., Bork, B. A., Boschi, R., Bose, V., Bouffanais, S., Bozzi, Y., Bradaschia, A., Brady, C., Braginsky, P. R., Branchesi, V. B., Brau, M., Briant, J. E., Brillet, T., Brinkmann, A., Brisson, M., Brockill, V., Brooks, P., Brown, A. F., Brown, D. A., Brown, D. D., Buchanan, N. M., Buikema, C. C., Bulik, A., Bulten, T., Buonanno, H. J., Buskulic, A., Buy, D., Byer, C., Cadonati, R. L., Cagnoli, L., Cahillane, G., Calderón Bustillo, C., Callister, J., Calloni, T., Camp, E., Cannon, J. B., Cao, K. C., Capano, J., Capocasa, C. D., Carbognani, E., Caride, F., Casanueva Diaz, S., Casentini, J., Caudill, C., Cavaglià, S., Cavalier, M., Cavalieri, F., Cella, R., Cepeda, G., Cerboni Baiardi, C. B., Cerretani, L., Cesarini, G., Chakraborty, E., Chatterji, R., Chalermsongsak, S., Chamberlin, T., Chan, S. J., Chao, M., Charlton, S., Chassande Mottin, P., Chen, E., Chen, H. Y., Cheng, Y., Chincarini, C., Chiummo, A., Cho, A., Cho, H. S., Chow, M., Christensen, J. H., Chu, N., Chua, Q., Chung, S., Ciani, S., Clara, G., Clark, F., Clark, J. A., Cleva, M., Coccia, F., Cohadon, E., Colla, P. F., Collette, A., Cominsky, C. G., Constancio, L., Conte, M., Conti, A., Cook, L., Corbitt, D., Cornish, T. R., Corsi, N., Cortese, A., Costa, S., Coughlin, C. A., Coughlin, M. W., Coulon, S. B., Countryman, J. P., Couvares, S. T., Cowan, P., Coward, E. E., Cowart, D. M., Coyne, M. J., Coyne, D. C., Craig, R., Creighton, K., Cripe, J. D. E., Crowder, J., Cumming, S. G., Cunningham, A., Cuoco, L., Dal Canton, E., Danilishin, T., D'Antonio, S. L., Danzmann, S., Darman, K., Dattilo, N. S., Dave, V., Daveloza, I., Davier, H. P., Davies, M., Daw, G. S., Day, E. J., Debra, R., Debreczeni, D., Degallaix, G., De Laurentis, J., Deléglise, M., Del Pozzo, S., Denker, W., Dent, T., Dereli, T., Dergachev, H., Derosa, V., De Rosa, R. T., Desalvo, R., Dhurandhar, R., Díaz, S., Di Fiore, M. C., Di Giovanni, L., Di Lieto, M., Di Pace, A., Di Palma, S., Di Virgilio, I., Dojcinoski, A., Dolique, G., Donovan, V., Dooley, F., Doravari, K. L., Douglas, S., Downes, R., Drago, T. P., Drever, M., Driggers, R. W. P., J. C., Du, Ducrot, Z., Dwyer, M., Edo, S. E., Edwards, T. B., Effler, M. C., Eggenstein, A., Ehrens, H. B., Eichholz, P., Eikenberry, J., Engels, S. S., Essick, W., Etzel, R. C., Evans, T., Evans, M., Everett, T. M., Factourovich, R., Fafone, M., Fair, V., Fairhurst, H., Fan, S., Fang, X., Farinon, Q., Farr, S., Farr, B., Favata, W. 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Chamberlin, S. .j., Chen, H. .y., Cho, H. .s., Chow, J. .h., Clark, J. .a., Collette, C. .g., Corbitt, T. .r., Costa, C. .a., Coughlin, M. .w., Coughlin, S. .b., Countryman, S. .t., Cowan, E. .e., Coward, D. .m., Cowart, M. .j., Coyne, D. .c., Creighton, J. .d. .e., Crowder, S. .g., Danilishin, S. .l., D’Antonio, S., Darman, N. .s., Daveloza, H. .p., Davies, G. .s., Daw, E. .j., De Laurentis, M., Derosa, R. .t., De Rosa, R., Díaz, M. .c., Dooley, K. .l., Downes, T. .p., Drever, R. .w. .p., Driggers, J. .c., Dwyer, S. .e., Edo, T. .b., Edwards, M. .c., Eikenberry, S. .s., Essick, R. .c., Evans, T. .m., Farr, W. .m., Fejer, M. .m., Ferreira, E. .c., Fisher, R. .p., Fricke, T. .t., Frolov, V. .v., Gabbard, H. .a. .g., Gair, J. .r., Gaonkar, S. .g., Garufi, F., Giaime, J. .a., Giardina, K. .d., Gonzalez Castro, J. .m., Gordon, N. .a., Gorodetsky, M. .l., Gossan, S. .e., Graff, P. .b., GRECO, GIUSEPPE, Green, A. .c., GUIDI, GIANLUCA MARIA, Gupta, M. .k., Gushwa, K. .e., Gustafson, E. .k., Hacker, J. .j., Hall, B. .r., Hall, E. .d., Hanke, M. .m., Hannam, M. .d., HARMS, JAN, Harry, G. .m., Harry, I. .w., Hart, M. .j., Hartman, M. .t., Heintze, M. .c., Heng, I. .s., Heptonstall, A. .w., Hodge, K. .a., Hollitt, S. .e., Holz, D. .e., Hosken, D. .j., Houston, E. .a., Howell, E. .j., Hu, Y. .m., Huerta, E. .a., Huttner, S. .h., Ingram, D. .r., Isa, H. .n., Iyer, B. .r., Johnson, W. .w., Jones, D. .i., Jonker, R. .j. .g., Kalaghatgi, C. .v., Kanner, J. .b., Kehl, M. .s., Kelley, D. .b., Key, J. .s., Khalili, F. .y., Khazanov, E. .a., King, E. .j., King, P. .j., Kinzel, D. .l., Kissel, J. .s., Koehlenbeck, S. .m., Korth, W. .z., Kozak, D. .b., Lackey, B. .d., Lasky, P. .d., Lebigot, E. .o., Lee, C. .h., Lee, H. .k., Lee, H. .m., Leong, J. .r., Levine, B. .m., Li, T. .g. .f., Littenberg, T. .b., Lockerbie, N. .a., Lombardi, A. .l., Lord, J. .e., Lough, J. .d., Lundgren, A. .p., Macleod, D. .m., Magee, R. .m., Mansell, G. .l., Markosyan, A. .s., MARTELLI, FILIPPO, Martin, I. .w., Martin, R. .m., Martynov, D. .v., Marx, J. .n., Massinger, T. .j., Mcclelland, D. .e., Mcguire, S. .c., Mcmanus, D. .j., Mcwilliams, S. .t., Meadors, G. .d., Mercer, R. .a., Meyers, P. .m., Mikhailov, E. .e., Milano, L., Mitrofanov, V. .p., Mohapatra, S. .r. .p., MONTANI, MATTEO, Moore, B. .c., Moore, C. .j., Morriss, S. .r., Mow Lowry, C. .m., Mueller, C. .l., Muir, A. .w., Murphy, D. .j., Murray, P. .g., Nayak, R. .k., Nguyen, T. .t., Nielsen, A. .b., Normandin, M. .e., Nuttall, L. .k., O’Dell, J., Ogin, G. .h., Oh, J. .j., Oh, S. .h., O’Reilly, B., O’Shaughnessy, R., Ottaway, D. .j., Ottens, R. .s., Owen, B. .j., Pai, S. .a., Palamos, J. .r., Pant, B. .c., Papa, M. .a., Paris, H. .r., Pearlstone, B. .l., PIERGIOVANNI, FRANCESCO, Pinto, I. .m., Premachandra, S. .s., Price, L. .r., Prodi, G. .a., Quintero, E. .a., Raab, F. .j., Rabeling, D. .s., Reed, C. .m., Reitze, D. .h., Reyes, S. .d., Robertson, N. .a., Rollins, J. .g., Roma, V. .j., Romie, J. .h., Sanchez, E. .j., Sanders, J. .r., Sathyaprakash, B. .s., Saulson, P. .r., Savage, R. .l., Schofield, R. .m. .s., Schutz, B. .f., Scott, S. .m., Sengupta, A. .s., Shaddock, D. .a., Shahriar, M. .s., Shoemaker, D. .h., Shoemaker, D. .m., Silva, A. .d., Singer, L. .p., Sintes, A. .m., Slagmolen, B. .j. .j., Smith, J. .r., Smith, N. .d., Smith, R. .j. .e., Son, E. .j., Srivastava, A. .k., Stephens, B. .c., Strain, K. .a., STRATTA, MARIA GIULIANA, Strauss, N. .a., Stuver, A. .l., Summerscales, T. .z., Sutton, P. .j., Swinkels, B. .l., Szczepańczyk, M. .j., Tanner, D. .b., Tarabrin, S. .p., Thirugnanasambandam, M. .p., Thomas, E. .g., Thorne, K. .a., Thorne, K. .s., Tokmakov, K. .v., Torres, C. .v., Torrie, C. .i., Tringali, M. .c., Unnikrishnan, C. .s., Urban, A. .l., Usman, S. .a., van Bakel, N., van Beuzekom, M., van den Brand, J. .f. .j., Vander Hyde, D. .c., van der Schaaf, L., van Heijningen, J. .v., van Veggel, A. .a., Veitch, P. .j., VETRANO, FLAVIO, VICERE', ANDREA, Vine, D. .j., Vousden, W. .d., Vyatchanin, S. .p., Wade, A. .r., Wade, L. .e., Ward, R. .l., Weinstein, A. .j., Whelan, J. .t., White, D. .j., Whiting, B. .f., Williams, R. .d., Williamson, A. .r., Willis, J. .l., Wimmer, M. .h., Wipf, C. .c., Wright, J. .l., Yancey, C. .c., Yap, M. .j., Zadrożny, A., Zhu, X. .j., Zucker, M. .e., and Zuraw, S. .e.
Subjects: [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Nuclear and High Energy Physics, [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Astronomy, Astrophysics::High Energy Astrophysical Phenomena, Binary number, GW150914, FOS: Physical sciences, ADVANCED LIGO, Astrophysics, General Relativity and Quantum Cosmology (gr-qc), Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Signal, General Relativity and Quantum Cosmology, GW150914, cWB search, [ PHYS.GRQC ] Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], cWB search, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, Chirp, Waveform, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), QC, QB, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, Estimation theory, Gravitational wave, Settore FIS/01 - Fisica Sperimentale, Detector, [ PHYS.ASTR.HE ] Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], LIGO, Physics and Astronomy, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], [ PHYS.ASTR.IM ] Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The gravitational-wave signal GW150914 was first identified on Sept 14 2015 by searches for short-duration gravitational-wave transients. These searches identify time-correlated transients in multiple detectors with minimal assumptions aboutthe signal morphology, allowing them to be sensitive to gravitational waves emitted by a wide range of sources including binary black-hole mergers. Over the observational period from September 12th to October 20th 2015, these transient searches were sensitive to binary black-hole mergers similar to GW150914 to an average distance of $\sim 600$ Mpc. In this paper, we describe the analyses that first detected GW150914 as well as the parameter estimation and waveform reconstruction techniques that initially identified GW150914 as the merger of two black holes. We find that the reconstructed waveform is consistent with the signal from a binary black-hole merger with a chirp mass of $\sim 30 \, M_\odot$ and a total mass before merger of $\sim 70 \, M_\odot$ in the detector frame., Comment: 20 pages, 12 figures, https://dcc.ligo.org/LIGO-P1500229/public
Published: 2016

16. Combined Aortic and Mitral Valve Repair

Author: Toshinobu Kazui, Hiroshi Izumoto, Hajime Kin, Kawazoe K, Takayuki Nakajima, and Kazuaki Ishihara
Subjects: Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.medical_treatment, Heart Valve Diseases, 1 year follow up, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Aortic valve repair, Valve replacement, medicine, Humans, Endocarditis, Cardiac Surgical Procedures, Survival rate, Aged, Retrospective Studies, Mitral valve repair, Cardiopulmonary Bypass, business.industry, General Medicine, Annuloaortic ectasia, Middle Aged, medicine.disease, Surgery, Treatment Outcome, 030228 respiratory system, Aortic Valve, Concomitant, Mitral Valve, Radiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract: Six patients, median age 63.3 years (range, 54 to 68 years), underwent concomitant mitral and aortic valve repair from January 2000 to August 2001. Surgical reports and general clinical data were reviewed retrospectively. All patients had degenerative valvular disease, although one patient also had annuloaortic ectasia. There were no surgical complications. The 30 day survival rate was 100%, and the New York Heart Association classification score improved from 2.2 (range, 1 to 2) preoperative, to 1.0 (all patients) postoperatively ( p = 0.03) As measured by intraoperative transesophageal echocardiography, the left ventricular end-diastolic diameter decreased from 6.0 cm (range, 5.4 to 6.3 cm) to 4.7 cm (range, 4.0 to 5.2 cm) and the left ventricular end-systolic diameter decreased from 3.7 cm (range, 3.4 to 4.1cm) to 3.1 cm (range, 2.9 to 3.7 cm). No patient developed endocarditis, thromboembolism or hemorrhage. There was no valve related morbidity during a 1 year follow up. Double valve repair is an acceptable alternative to valve replacement in selected patients with some types of valvular disease. Longer term follow up with greater numbers of patients is needed.
Published: 2003

17. ESTIMATING CARBON STOCK CHANGES OF MANGROVE FORESTS USING SATELLITE IMAGERY AND AIRBORNE LiDAR DATA IN THE SOUTH SUMATRA STATE, INDONESIA

Author: Maeda, Y., primary, Fukushima, A., additional, Imai, Y., additional, Tanahashi, Y., additional, Nakama, E., additional, Ohta, S., additional, Kawazoe, K., additional, and Akune, N., additional
Published: 2016
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18. Impaired Peripheral Vasodilation in Ischemic and Nonischemic Limbs of Patients with Unilateral Arteriosclerosis Obliterans

Author: Katsuhiko Hiramori, Kunihiro Yoshioka, Kawazoe K, Shigehiro Ito, Kenji Komoda, Takayuki Nakajima, Shinji Makita, Atsushi Ohira, Motoyuki Nakamura, and Atsuo Hirose
Subjects: medicine.medical_specialty, Arteriosclerosis obliterans, business.industry, medicine.medical_treatment, Hemodynamics, Vasodilation, Blood flow, medicine.disease, Revascularization, Surgery, Peripheral, body regions, Internal medicine, Circulatory system, Occlusion, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract: Limb vessel vasodilation plays an important role in the regulation of skeletal muscle blood flow during exercise. However, little documentation is available that describes the vasodilatory response of peripheral vessels in patients with arteriosclerosis obliterans (ASO). This study investigates possible impairment of basal blood flow and response in ischemic and nonischemic legs of patients with ASO, and the effect of revascularization on leg hemodynamics. Basal calf blood flow and reactive hyperemic response to femoral occlusion were measured plethysmographically in 20 patients with unilateral ASO (20 stenotic legs and 20 nonstenotic legs) and eight healthy subjects (eight control legs). Eight stenotic legs underwent percutaneous transluminal angioplasty or surgical revascularization. Basal calf blood flow and peak hyperemic flow was significantly lower in stenotic and nonstenotic legs than in control legs. After revascularization, basal flow was unchanged in stenotic legs but elevated in nonstenotic legs (from 2.5 ±0.3 to 3.4 ±0. 4 mL/min/dL tissue, p Basal blood flow and maximum vasodilatory response of resistance vessels are impaired irrespective of the side of conduit vessel involvement. The vascular response of the nonstenotic side is significantly enhanced after revascularization of the contralateral stenotic lesions. These suggest that neural or circulating vasoacting factor(s) originating from the stenotic limb may contribute to peripheral circulatory disturbance in claudicants.
Published: 1998

19. Lifesaving example of inferior infarction which combines ventricular septum perforation and posterior papillar muscle fracture

Author: Hidehiko Aoki, Masataka Shiina, Yoshiteru Moriai, Kawazoe K, Masataka Nasu, Tomomi Suzuki, Katuhiko Hiramori, and Masashi Shibata
Subjects: medicine.medical_specialty, Ventricular Septal Perforation, business.industry, Inferior Myocardial Infarction, Internal medicine, medicine, Cardiology, Myocardial infarction, Papillary muscle rupture, medicine.disease, business
Abstract: 症例は65歳の男性。就眠中に胸痛が出現し翌朝当科を受診した。収縮期血圧は90mmHg台と低下し,胸骨左縁第4肋間に全収縮期雑音と肺野に湿性ラ音を聴取した。心電図上II,III,aVFでST上昇があり,心エコー図検査で心室中隔穿孔を認めた。肺体血流比(Qp/Qs)は2.5,左右シャント率は62%であった。冠動脈造影では右冠動脈完全閉塞の一枝病変であった。大動脈内バルーンポンプを適用し,入室当日に心室中隔穿孔パッチ閉鎖術を行った。また術中所見で後乳頭筋部分断裂もあり,隣接の健常乳頭筋に腱索付き筋束を縫着した。術後第10病日に,さらに後乳頭筋の完全断裂をきたした。断裂部は初回手術でみた後乳頭筋束縫着部より根部であった。第11病日に僧帽弁形成術を行い,第39病日に退院した。心筋梗塞症に心室中隔穿孔と後乳頭筋完全断裂を合併した臨床例の報告は,調べ得た限り本邦では本例を含めて2例のみである。緊急手術による救命例は本例が初めてである。
Published: 1998

20. Effect of the Maze Procedure for Atrial Fibrillation on Atrial and Brain Natriuretic Peptide

Author: Kenji Ueshima, Makoto Chiba, Naoshi Arakawa, Motoyuki Nakamura, Yoko Yagi, Hiroyuki Niinuma, Katsuhiko Hiramori, and Kawazoe K
Subjects: Male, medicine.medical_specialty, Time Factors, Heart disease, medicine.drug_class, Heart Valve Diseases, Nerve Tissue Proteins, Intracardiac injection, Atrial natriuretic peptide, Internal medicine, Atrial Fibrillation, Natriuretic Peptide, Brain, medicine, Natriuretic peptide, Humans, Heart Atria, cardiovascular diseases, Heart Failure, business.industry, valvular heart disease, Atrial fibrillation, Middle Aged, Water-Electrolyte Balance, medicine.disease, Brain natriuretic peptide, Case-Control Studies, Heart failure, Anesthesia, Exercise Test, cardiovascular system, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Atrial Natriuretic Factor, Follow-Up Studies
Abstract: We studied plasma levels of atrial and brain natriuretic peptides at rest and after exercise before and after intracardiac surgery with and without the maze procedure in patients with chronic heart failure secondary to valvular heart disease. The present study found that an increased response of both cardiac natriuretic peptides is attenuated with resulting water retention after the maze procedure.
Published: 1997

21. Quality of Life of the Patients with Tetralogy of Fallot Corrected under Simple Deep Hypothermia More than 20 Years Ago

Author: Kawazoe K, Katsuhiro Niitu, Yoshitaka Shiina, Kazuaki Ishihara, and Koutarou Oyama
Subjects: medicine.medical_specialty, Quality of life, business.industry, Anesthesia, Medicine, Hypothermia, medicine.symptom, business, medicine.disease, Surgery, Tetralogy of Fallot
Abstract: 1960年～1976年までの期間に, 当科では体外循環を用いない表面冷却単純超低体温法によるファロー四徴症 (TOF) 根治術を167例に行った. 術後20年以上を経過し, かつ現住所が確認された生存例59例にアンケートを行い, 54例 (男25名, 女29名) からの回答を得た (回答率91.5%). 手術時年齢は6カ月～19歳 (5.3±4.2歳), 調査時年齢は20～51歳であった. NYHA分類ではI度43例 (80%), II度11例 (20%) でありIII度以上の症例はなかった. また, VSD遺残短絡に対する再手術を2例に施行し, ともに救命し社会復帰した. 28名が結婚しており, 女性既婚者の88%がすでに出産していた. 子供の総数は34人で心疾患は認めなかった. 就業については全体の94%に当たる51名が就職していた (うち8名は主婦). TOF術後20年以上の遠隔期症例の身体状況・社会状況はおおむね良好であった.
Published: 2001

22. 097 * AORTIC VALVULOPLASTY FOR AORTIC INSUFFICIENCY

Author: Mukaida, M., primary, Kawazoe, K., additional, Koizumi, J., additional, Kamada, T., additional, Tsuboi, J., additional, Ikai, A., additional, and Okabayashi, H., additional
Published: 2014
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23. Studies on medicinal plants of Yunnan province: Constituents of Gentiana rigescens

Author: Suyama, Y, primary, Tanaka, N, additional, Kurimoto, SI, additional, Kawazoe, K, additional, Murakami, K, additional, Sun, HD, additional, Li, SL, additional, Takaishi, Y, additional, and Kashiwada, Y, additional
Published: 2014
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24. Expression and localization of tumour necrosis factor-alpha and its converting enzyme in human abdominal aortic aneurysm

Author: Mamoru Satoh, Katsuhiko Hiramori, Kawazoe K, Chihaya Maesawa, Motoyuki Nakamura, Hiroshi Izumoto, Takayuki Nakajima, Hidetoshi Satoh, and Tomoyuki Masuda
Subjects: Male, Pathology, medicine.medical_specialty, ADAM17 Protein, Statistics, Nonparametric, Proinflammatory cytokine, Aortic aneurysm, Aneurysm, Adventitia, medicine.artery, medicine, Humans, cardiovascular diseases, RNA, Messenger, Aged, Aorta, business.industry, Reverse Transcriptase Polymerase Chain Reaction, Tumor Necrosis Factor-alpha, Abdominal aorta, Metalloendopeptidases, General Medicine, medicine.disease, Immunohistochemistry, Abdominal aortic aneurysm, ADAM Proteins, medicine.anatomical_structure, cardiovascular system, Female, Radiology, business, Artery, Aortic Aneurysm, Abdominal
Abstract: Abdominal aortic aneurysm (AAA) is characterized by chronic aortic wall inflammation and loss of matrix components. Proinflammatory cytokines such as tumour necrosis factor-alpha (TNF-alpha) are thought to be involved in this inflammatory process and, therefore, to play an important role in the pathogenesis of human AAA. TNF-alpha-converting enzyme (TACE) has recently been purified and cloned as a disintegrin and metalloproteinase that converts TNF-alpha precursor into its mature form. The aim of the present study was to determine whether TNF-alpha and TACE were expressed and localized in aortic tissues in human AAA. Infrarenal aortic tissues were obtained from AAA patients (n=19) undergoing elective aneurysm reconstruction and from autopsy cases without cardiovascular disorders as normal controls (n=5). Internal thoracic artery samples were also obtained from patients with coronary artery disease undergoing coronary artery bypass grafting to represent biopsied conduit vessels (n=5). The AAA specimens were taken from the mid-portion of the aneurysm and from the longitudinal transition zone between the non-dilated aorta and the proximal aspect of the aneurysm. TNF-alpha and TACE mRNA levels were determined by real-time quantitative reverse transcriptase-PCR. Expression levels of both TNF-alpha mRNA and TACE mRNA were significantly greater in the transition zone than in the mid-portion (both P0.05). Expression levels of both forms of mRNA were significantly higher in AAA samples than in control aortas or atherosclerotic arteries. There was a significant correlation between the expression of TNF-alpha mRNA with that of TACE mRNA in AAA (r=0.54, P0.005). Immunostaining was positive for both TNF-alpha and TACE in CD68-positive macrophages in the media and adventitia obtained from the transition zone in AAA, whereas neither TNF-alpha nor TACE was expressed in control vessels. In conclusion, the concomitant activation and localization of TNF-alpha and TACE in the media and adventitia of the transition zone in human AAA underlines the importance of this system in the pathogenesis of this disorder.
Published: 2003

25. PP088—Nitrosonifedipine, a photodegradation product of nifedipine, suppress the progression of diabetic nephropathy with the endothelial dysfunction

Author: Sakurada, T., primary, Miyako, K., additional, Horinouchi, Y., additional, Teraoka, K., additional, Kujime, T., additional, Kawazoe, K., additional, Houchi, H., additional, Tamaki, T., additional, and Minakuchi, K., additional
Published: 2013
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26. Effects of mitral and/or aortic valve replacement or repair on endothelium-dependent peripheral vasorelaxation and its relation to improvement in exercise capacity

Author: Makoto Chiba, Katsuhiko Hiramori, Kawazoe K, Naoshi Arakawa, Hiroaki Yoshida, Kenji Ueshima, Shinji Makita, and Motoyuki Nakamura
Subjects: Aortic valve, Male, medicine.medical_specialty, Heart disease, Endothelium, Vasodilation, Cardiomegaly, Aortic valve replacement, Internal medicine, Mitral valve, medicine, Humans, Exercise, Aged, Heart Failure, business.industry, Middle Aged, medicine.disease, Peripheral, Oxygen, Forearm, medicine.anatomical_structure, Regional Blood Flow, Heart failure, Aortic Valve, Heart Valve Prosthesis, Cardiology, Mitral Valve, Female, Endothelium, Vascular, Cardiology and Cardiovascular Medicine, business, Atrial Natriuretic Factor
Abstract: In conclusion, we observed that the reduced peripheral endothelium-dependent response is restored after recovery from chronic heart failure, and that improvement in this type of vascular dysfunction is related to an increase in exercise capacity.
Published: 1996

27. Studies on the constituents of Cudrania tricuspidata

Author: Sasaki, H, primary, Sato, H, additional, Kashiwada, Y, additional, Kawazoe, K, additional, Murakami, K, additional, Shibata, H, additional, Sun, HD, additional, Li, SL, additional, and Takaishi, Y, additional
Published: 2012
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28. PP 95 Targeted therapy for mesothelioma using anti-podoplanin antibody NZ-1 via ADCC

Author: Nishioka, Y., primary, Abe, S., additional, Kishuku, M., additional, Hanibuchi, M., additional, Kakiuchi, S., additional, Kawazoe, K., additional, Minakuchi, K., additional, Kaneko, M.K., additional, and Kato, Y., additional
Published: 2011
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29. ChemInform Abstract: Enantioselective Preparation of 1-Benzyloxy-3-methyl-6-heptene-2,4- diols: Total Synthesis of (+)-Prelactone C.

Author: ESUMI, T., primary, FUKUYAMA, H., additional, ORIBE, R., additional, KAWAZOE, K., additional, IWABUCHI, Y., additional, IRIE, H., additional, and HATAKEYAMA, S., additional
Published: 2010
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30. ChemInform Abstract: Three β-Coumaranones from Sparaxis tricolor.

Author: IMAKURA, Y., primary, KAWATA, T., additional, HARA, H., additional, HAYAFUJI, Y., additional, SINGHU, T., additional, KOBAYASHI, S., additional, KAWAZOE, K., additional, TAKAISHI, Y., additional, HASHIMOTO, T., additional, and YAMASITA, S., additional
Published: 2010
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31. [Clinical application of recombinant human SOD for the protection of ischemia reperfusion injury during open heart surgery]

Author: Shibata T, Yamamoto F, Kosakai Y, Kawazoe K, Hiroyoshi Komai, Ichikawa H, Ohashi T, Shimada Y, Nakajima N, and Kawashima Y
Subjects: Oxygen Consumption, Superoxide Dismutase, Myocardium, Luminescent Measurements, Heart Arrest, Induced, Myocardial Ischemia, Humans, Myocardial Reperfusion Injury, Middle Aged, Recombinant Proteins
Abstract: We have applied recombinant human superoxide dismutase (RH-SOD) to prevent ischemia reperfusion injury in the patients who received open heart surgery. Twenty-four patients were divided into 2 groups; group A had no treatment as control and group B received bolus injection of RH-SOD (35,000 IU/kg) into cardiopulmonary bypass 5 minutes before reperfusion. Arterial and coronary sinus blood was collected to measure chemiluminescence (ChL) value, SOD activity, lactate and pyruvate level, and several parameters of myocardial oxygen metabolism after reperfusion. Arterio-venous difference of ChL value showed the tendency of less ChL generation of the heart in group B compared with those in group A. But no other parameters showed significant difference between the two groups. Our data suggested that this way of the administration of RH-SOD failed to improve the myocardial protection during open heart surgery. Further investigation, such as dose response study, might be required to determine whether RH-SOD possess beneficial effects or not in the clinical setting.
Published: 1993

32. Angiotensin II receptor blocker attenuates PDGF-induced mesangial cell migration in a receptor-independent manner

Author: Ishizawa, K., primary, Izawa-Ishizawa, Y., additional, Dorjsuren, N., additional, Miki, E., additional, Kihira, Y., additional, Ikeda, Y., additional, Hamano, S., additional, Kawazoe, K., additional, Minakuchi, K., additional, Tomita, S., additional, Tsuchiya, K., additional, and Tamaki, T., additional
Published: 2009
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33. Apicoaortic conduit for the dilated phase of hypertrophic obstructive cardiomyopathy as an alternative to heart transplantation

Author: Matsushita, T., primary, Kawase, T., additional, Tsuda, E., additional, and Kawazoe, K., additional
Published: 2008
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34. Present status of clinic for complementary and alternative medicine at university hospitals in Japan; a case of Tokushima University Hospital

Author: Yanagawa, H., primary, Terao, J., additional, Takeda, E., additional, Takaishi, Y., additional, Kashiwada, Y., additional, Kawazoe, K., additional, Fushitani, S., additional, Tsuchiya, K., additional, Yamauchi, A., additional, Sato, C., additional, Irahara, M., additional, and Kagawa, S., additional
Published: 2008
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35. Studies on the constituents of Chloranthus spicatus (Thunb.) Makino

Author: Kim, SY, primary, Kashiwada, Y, additional, Takaishi, Y, additional, Kawazoe, K, additional, Murakami, K, additional, and Li, SL, additional
Published: 2008
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36. Field-induced transitions in a single crystal of ErZn2

Author: Kitai, T, primary, Yoshida, H, additional, Abe, S, additional, Kawae, T, additional, Kaneko, T, additional, and Kawazoe, K, additional
Published: 2006
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37. Endoscope disinfection using chlorine dioxide in an automated washer-disinfector

Author: Isomoto, H., primary, Urata, M., additional, Kawazoe, K., additional, Matsuda, J., additional, Nishi, Y., additional, Wada, A., additional, Ohnita, K., additional, Hirakata, Y., additional, Matsuo, N., additional, Inoue, K., additional, Hirayama, T., additional, Kamihira, S., additional, and Kohno, S., additional
Published: 2006
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38. Scenecabinet Live!: Generation of Semantic Metadata Combining Media Analysis and User Interface Technologies

Author: Kuwano, H., primary, Kon'ya, Y., additional, Yamada, T., additional, and Kawazoe, K., additional
Published: 2005
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39. Successful Removal from the Duodenum of Swallowed Sewing Needles Using Devised Endoscopic Forceps

Author: Enjoji, A., primary, Nagata, Y., additional, Furuichi, A., additional, Kawakami, S., additional, Saiwai, H., additional, Furui, J., additional, Kawazoe, K., additional, and Kanematsu, T., additional
Published: 2004
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40. Perioperative Serum Procalcitonin Concentrations in Patients with Acute Aortic Dissection

Author: Kin, H., primary, Kawazoe, K., additional, Nakajima, T., additional, Niinuma, H., additional, Kataoka, T., additional, Endo, S., additional, and Inada, K., additional
Published: 2003
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41. Effects of Quantization Noise and Distortion in EPWM Transmitters for OFDM Signal Amplification.

Author: Umali, E.M., Kawazoe, K., Toyama, Y., and Yamao, Y.
Published: 2009
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42. Behavior of the gas-puff z-pinch plasma during the initial phase of discharge in IPP method.

Author: Imasaka, K., Masaki, T., Kawazoe, K., Suehiro, J., and Hara, M.
Abstract: Previous gas-puff z-pinch experiments in our study showed that spatial stability of hot spots in radial direction was obtained by using an inductive pulsed power generator. However, it was confirmed that the injected gas was expanded to radial direction during initial phase of discharge. Therefore it was thought that the compressing process and z-pinch characteristics were influenced by the shape of the injected gas column. In this study, pinching phenomenon during initial phase of discharge was observed by changing the gap length and delay time which was defined as a time from gas injection to discharge onset. Framing photographs of initial compressing phase of the z-pinch plasma revealed that the profile of the initial gas column was influenced by the gap length and delay time. Compression velocity of the initial gas column became slower as the gap length and delay time increased. [ABSTRACT FROM PUBLISHER]
Published: 2000

43. Observation on early gastric cancer

Author: Wakisaka, J., Kabakino, T., Fukuhisa, Y., Deguchi, H., Kawazoe, K., and Fujita, T.
Published: 1969
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44. Reduction of the source size of gas-puff z-pinch plasmas using an inductive pulsed power system

Author: Imasaka, K., primary, Kawazoe, K., additional, Kawauchi, K., additional, Hara, S., additional, Suehiro, J., additional, and Hara, M., additional
Published: 2000
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45. CHRONIC HEPATITIS C BETA‐INTERFERON‐INDUCED SEVERE HYPERTRIGLYCERIDAEMIA WITH APOLIPOPROTEIN E PHENOTYPE E3/2

Author: Homma, Y, primary, Kawazoe, K, additional, Ito, T, additional, Ide, H, additional, Takahashi, H, additional, Ueno, F, additional, and Matsuzaki, S, additional
Published: 2000
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46. FLUCTUATIONS OF THE CARDIAC FUNCTION WITH EXTRAANATOMICAL BYPASS IN DOGS

Author: Ishibashi, K., primary, Shiraishi, Y., additional, Umezu, M., additional, and Kawazoe, K., additional
Published: 2000
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47. Bacterial isolates from patients with preterm labor with and without preterm rupture of the fetal membranes

Author: Mikamo, H., primary, Sato, Y., additional, Hayasaki, Y., additional, Kawazoe, K., additional, Hua, Y.X., additional, and Tamaya, T., additional
Published: 1999
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48. Low-power and high-quality signal transmission baseband LSIC for personal communications

Author: Kobayashi, K., primary, Kubota, S., additional, Enomoto, K., additional, Seki, K., additional, Kawazoe, K., additional, Sakata, T., additional, Matsumoto, Y., additional, and Hattori, T., additional
Published: 1998
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49. VIBRATION CONTROL OF SHALLOW SHELL STRUCTURES USING A SHELL-TYPE DYNAMIC VIBRATION ABSORBER

Author: Aida, T., primary, Aso, T., additional, Nakamoto, K., additional, and Kawazoe, K., additional
Published: 1998
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50. Studies on the pathogenicity of anaerobes, especiallyPrevotella bivia, in a rat pyometra model

Author: Mikamo, H., primary, Kawazoe, K., additional, Izumi, K., additional, Watanabe, K., additional, Ueno, K., additional, and Tamaya, T., additional
Published: 1998
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