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11. A New Quantitative Multi-parameter Method Improves the Accuracy of Age Estimation from Oral Findings

Author

Kawashima, Wataru, Hatake, Katsuhiko, Morimura, Yoshifumi, Kudo, Risa, Nakanishi, Mari, Tamaki, Shigehiro, Kasuda, Shogo, Yuui, Katsuya, and Ishitani, Akiko

Subjects
stomatognathic diseases, stomatognathic system, Macroscopic examination, Age estimation, Dental parameters, Forensic science, Oral findings
Abstract

In forensic science, age estimation is an important step in identifying unidentified cadavers. As teeth are resistant to environmental degradation for long periods of time, they are often used to estimate age. Although there have been many reports of age estimation based on dental morphology, these methods tend to be subjective and cannot be used i n the case of edentulous jaws. In the present study, we developed a new method of age estimation from dental parameters (number of upper teeth [UT], lower teeth [LT], and prostheses [NP]; tooth attrition [TA]; and occlusal area [OA]) and the mandibular angle (MA) measured at proposed an equation for calculating the age. The results show that the mean error of this method is similar to that of previous methods, and even demonstrated improved accuracy in subjects aged >60 years. We also proposed an equation for age estimation from only the MA, and showed that we can perform age estimation even in edentulous cases using this equation. Because our method is superior in its simplicity, objectivity, and applicability when compared with previous methods, we believe our method wll prove useful for age estimation in a wide variety of cases., 博士（医学）・甲611号・平成26年3月17日

Published
2013

12. Generation of nitrene by the photolysis of N-substituted iminodibenzothiophene

Author

Morita, Hiroyuki, Tatami, Atsushi, Maeda, Tetsuo, Byung Ju Kim, Kawashima, Wataru, Yoshimura, Toshiaki, Abe, Hitoshi, and Akasaka, Takeshi

Subjects
Nitrogen compounds -- Chemical properties, Nitrogen compounds -- Electric properties, Thiophene -- Chemical properties, Thiophene -- Electric properties, Photolysis -- Analysis, Biological sciences, Chemistry
Abstract

The photolyses of dibenzothiophene N-substituted sulfilimines was performed in the presence of several trapping reagents such as sulfides, olefins, and phosphorus compounds to evaluate their ability as photochemical nitrene sources. The potent nature of dibenzothiophene N-tosyl and N-acylsulfilimines as nitrogen sources are indicated by the good yield of sulfilimines, aziridines, and iminophosphoranes.

Published
2008

14. Impact of the platelet washing process on in vitro platelet properties, and the levels of soluble CD40 ligand and platelet-derived microparticles in the storage media.

Author

Oikawa, Shinji, Minegishi, Masayoshi, Endo, Kimika, Kawashima, Wataru, Kosunago, Satoshi, Oyama, Masanori, Suzuki, Ko, and Shimizu, Hiroshi

Subjects
STORAGE, ANTIGENS, BLOOD collection, ABO blood group system, BLOOD platelets, CELL membranes, GLYCOPROTEINS, PHYSIOLOGIC salines, PLATELETPHERESIS
Abstract

Background: A new platelet (PLT) additive solution, bicarbonated Ringer's solution supplemented with acid-citrate-dextrose Formula A, termed BRS-A, as well as a new automated closed system cell processor for washing PLTs have recently been developed. This study evaluated the in vitro properties of PLTs with the automated system versus the manual method, using the BRS-A additive solution for washing and storage.Methods: ABO-identical apheresis PLTs in 100% plasma were pooled and split equally for control (in 100% plasma or a manual method) and test (ACP215 automated system) units. In vitro characteristics of PLTs washed with the automated system were compared to those of PLTs in 100% plasma (Study 1) or washed with a manual method (Study 2) during the 7-day storage.Results: In Study 1, hypotonic shock response, aggregation response, mitochondrial membrane potential, adenosine triphosphate, and CD42b mean fluorescence intensity were comparable in the control and test groups during the 7-day storage. CD62P expression was lower in the test group than controls on Days 3 and 7. The level of platelet-derived microparticles (PDMPs) in the test group on Days 1 and 2 were higher than those in controls. In contrast, the levels of soluble CD40 ligand (sCD40L) and regulated upon activation of normal T-cell expressed and secreted (RANTES) in the test units were lower than controls. In Study 2, no significant differences were found in all in vitro properties except for PLT count and the levels of PDMPs in the test units were higher than controls during storage.Conclusion: Apheresis PLTs washed with the automated system using BRS-A additive solution maintained in vitro properties during storage. Washing methods influenced PDMP levels but not sCD40L and RANTES. [ABSTRACT FROM AUTHOR]

Published
2019
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18. STORAGE OF WASHED PLATELETS IN BRS-A PLATELET ADDITIVE SOLUTIONS BASED ON TWO TYPES OF CLINICALLY AVAILABLE BICARBONATED RINGER'S SOLUTIONS WITH DIFFERENT ELECTROLYTE CONCENTRATIONS

Author

Oikawa, Shinji, primary, Taguchi, Takeshi, additional, Endo, Kimika, additional, Hoshi, Takahiro, additional, Kawashima, Wataru, additional, Horibe, Yasuhito, additional, Urano, Shinichi, additional, Suzuki, Ko, additional, Minegishi, Masayoshi, additional, Itoh, Takashi, additional, and Shimizu, Hiroshi, additional

Published
2016
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19. Storage of washed platelets in BRS-A platelet additive solutions based on two types of clinically available bicarbonated Ringer's solutions with different electrolyte concentrations

Author

Oikawa, Shinji, primary, Taguchi, Takeshi, additional, Endo, Kimika, additional, Hoshi, Takahiro, additional, Kawashima, Wataru, additional, Horibe, Yasuhito, additional, Urano, Shinichi, additional, Suzuki, Ko, additional, Minegishi, Masayoshi, additional, Itoh, Takashi, additional, and Shimizu, Hiroshi, additional

Published
2015
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22. A New Quantitative Multi-parameter Method Improves the Accuracy of Age Estimation from Oral Findings.

Author

Kawashima, Wataru, Hatake, Katsuhiko, Morimura, Yoshifumi, Kudo, Risa, Nakanishi, Mari, Tamaki, Shigehiro, Kasuda, Shogo, Yuui, Katsuya, Ishitani, Akiko, Kawashima, Wataru, Hatake, Katsuhiko, Morimura, Yoshifumi, Kudo, Risa, Nakanishi, Mari, Tamaki, Shigehiro, Kasuda, Shogo, Yuui, Katsuya, and Ishitani, Akiko

Abstract

In forensic science, age estimation is an important step in identifying unidentified cadavers. As teeth are resistant to environmental degradation for long periods of time, they are often used to estimate age. Although there have been many reports of age estimation based on dental morphology, these methods tend to be subjective and cannot be used i n the case of edentulous jaws. In the present study, we developed a new method of age estimation from dental parameters (number of upper teeth [UT], lower teeth [LT], and prostheses [NP]; tooth attrition [TA]; and occlusal area [OA]) and the mandibular angle (MA) measured at proposed an equation for calculating the age. The results show that the mean error of this method is similar to that of previous methods, and even demonstrated improved accuracy in subjects aged >60 years. We also proposed an equation for age estimation from only the MA, and showed that we can perform age estimation even in edentulous cases using this equation. Because our method is superior in its simplicity, objectivity, and applicability when compared with previous methods, we believe our method wll prove useful for age estimation in a wide variety of cases., 博士（医学）・甲611号・平成26年3月17日

Published
2014

30. Photolytic aziridination by thianthrene sulfilimine derivatives

Author

Fujita, Tomoyuki, primary, Maeda, Tetsuo, additional, Ju Kim, Byung, additional, Tatami, Atsushi, additional, Miyamoto, Daisuke, additional, Kawaguchi, Hiroyuki, additional, Tsuchiya, Naoko, additional, Yoshida, Mikako, additional, Kawashima, Wataru, additional, and Morita, Hiroyuki, additional

Published
2008
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33. CURRENT TREND IN SKI INJURIES AND BOOT TOP FRACTURE

Author

KURIYAMA, SETSURO, primary, KAWASHIMA, WATARU, additional, UEMURA, SHOKICHI, additional, KUROKI, YOSHIKATSU, additional, FUJIMAKI, ETSUO, additional, MORI, YOSHIAKI, additional, KATAGIRI, TOMOO, additional, SAKAMOTO, KEIZO, additional, and SEKI, HIDEMASA, additional

Published
1980
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34. Autopsy case of a patient with 13q− syndrome

Author

Kasuda, Shogo, Morimura, Yoshifumi, Kudo, Risa, Kawashima, Wataru, Tamaki, Shigehiro, Nakanishi, Mari, and Hatake, Katsuhiko

Subjects
*AUTOPSY, *PHENOTYPES, *SUDDEN death, *CAUSES of death, *PSYCHOMOTOR disorders, *INTELLECTUAL disabilities, *CHROMOSOME abnormalities, *FOLLOW-up studies (Medicine), *LUNG abnormalities, *PITUITARY diseases
Abstract

Abstract: Partial deletion of the long arm of chromosome 13 results in 13q− syndrome, and phenotypes of affected patients vary widely. We describe an autopsy case of the sudden, unexpected death of a 17-year-old boy with 13q− syndrome. He had severe psychomotor retardation and had been receiving follow-up care. One day he was found dead in his house and autopsy was performed to elucidate the cause of death. Autopsy findings revealed lobulation anomalies of the lungs, hypoplasia of the adrenal and thyroid glands, and apituitarism due to hyperplasia of bone in the hypophyseal fossa. No other pathological lesions were observed. Chromosomal analysis confirmed interstitial deletion from the long arm of chromosome 13. Karyotype was 46,XY, del(13)(q14.3q32). We concluded that the patient died of multi-organ dysfunction due to apituitarism. Autopsy cases of 13q− syndrome are rare. Furthermore, lobulation anomalies and apituitarism associated with 13q− syndrome have not previously been described. This case report offers novel clues to elucidating critical regions of chromosome 13 associated with malformations of the lungs and pituitary gland. [Copyright &y& Elsevier]

Published
2010
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35. Soluble MICB serum levels correlate with disease stage and survival rate in patients with oral squamous cell carcinoma.

Author

Tamaki S, Kawakami M, Ishitani A, Kawashima W, Kasuda S, Yamanaka Y, Shimomura H, Imai Y, Nakagawa Y, Hatake K, and Kirita T

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell pathology, Enzyme-Linked Immunosorbent Assay, Female, Histocompatibility Antigens Class I biosynthesis, Humans, Male, Middle Aged, Mouth Neoplasms pathology, Neoplasm Staging, Biomarkers, Tumor blood, Carcinoma, Squamous Cell blood, Histocompatibility Antigens Class I blood, Mouth Neoplasms blood
Abstract

Background: Expression of ligands of natural killer group 2D (NKG2D) immunoreceptors, such as major histocompatibility complex class I-related chain A/B (MICA/B), has been proposed to play an important role in tumour immunosurveillance. Soluble forms of MICA/B are increased in sera of cancer patients and are postulated to impair antitumour immune response by downregulating expression of NKG2D immunoreceptors. Serum levels of soluble MICA have been shown to be of diagnostic significance in malignant diseases., Aims: The potential of soluble MICB (sMICB) as a marker for oral squamous cell carcinoma (OSCC) was investigated., Results: sMICB levels did not differ significantly from those in normal control individuals. However, the findings indicate that sMICB levels are significantly increased in stage IV OSCC and high sMICB levels are significantly associated with decreased survival rates in patients.

Published
2010

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