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795 results on '"Kawase, Ichiro"'

2. Induction of WT1 (Wilms' Tumor Gene)-Specific Cytotoxic T Lymphocytes by WT1 Peptide Vaccine and the Resultant Cancer Regression

Author

Oka, Yoshihiro, Tsuboi, Akihiro, Taguchi, Tetsuya, Osaki, Tadashi, Kyo, Taiichi, Nakajima, Hiroko, Elisseeva, Olga A., Oji, Yusuke, Kawakami, Manabu, Ikegame, Kazuhiro, Hosen, Naoki, Yoshihara, Satoshi, Wu, Fei, Fujiki, Fumihiro, Murakami, Masaki, Masuda, Tomoki, Nishida, Sumiyuki, Shirakata, Toshiaki, Nakatsuka, Shin-ichi, Sasaki, Ayako, Udaka, Keiko, Dohy, Hiroo, Aozasa, Katsuyuki, Noguchi, Shinzaburo, Kawase, Ichiro, Sugiyama, Haruo, and Sugimura, Takashi

Published
2004

5. Supplementary Figure 1 from Early [18F]Fluorodeoxyglucose Positron Emission Tomography at Two Days of Gefitinib Treatment Predicts Clinical Outcome in Patients with Adenocarcinoma of the Lung

Author

Takahashi, Ryo, primary, Hirata, Haruhiko, primary, Tachibana, Isao, primary, Shimosegawa, Eku, primary, Inoue, Atsuo, primary, Nagatomo, Izumi, primary, Takeda, Yoshito, primary, Kida, Hiroshi, primary, Goya, Sho, primary, Kijima, Takashi, primary, Yoshida, Mitsuhiro, primary, Kumagai, Toru, primary, Kumanogoh, Atsushi, primary, Okumura, Meinoshin, primary, Hatazawa, Jun, primary, and Kawase, Ichiro, primary

Published
2023
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6. Supplementary Figure Legends 1 from Early [18F]Fluorodeoxyglucose Positron Emission Tomography at Two Days of Gefitinib Treatment Predicts Clinical Outcome in Patients with Adenocarcinoma of the Lung

Author

Takahashi, Ryo, primary, Hirata, Haruhiko, primary, Tachibana, Isao, primary, Shimosegawa, Eku, primary, Inoue, Atsuo, primary, Nagatomo, Izumi, primary, Takeda, Yoshito, primary, Kida, Hiroshi, primary, Goya, Sho, primary, Kijima, Takashi, primary, Yoshida, Mitsuhiro, primary, Kumagai, Toru, primary, Kumanogoh, Atsushi, primary, Okumura, Meinoshin, primary, Hatazawa, Jun, primary, and Kawase, Ichiro, primary

Published
2023
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7. Exploring Relationships Between Tweet Numbers and Over-the-counter Drug Sales for Allergic Rhinitis: Retrospective Analysis

Author

Wakamiya, Shoko, Morimoto, Osamu, Omichi, Katsuhiro, Hara, Hideyuki, Kawase, Ichiro, Koshiba, Ryuji, Aramaki, Eiji, Wakamiya, Shoko, Morimoto, Osamu, Omichi, Katsuhiro, Hara, Hideyuki, Kawase, Ichiro, Koshiba, Ryuji, and Aramaki, Eiji

Abstract

Background: Health-related social media data are increasingly being used in disease surveillance studies. In particular, surveillance of infectious diseases such as influenza has demonstrated high correlations between the number of social media posts mentioning the disease and the number of patients who went to the hospital and were diagnosed with the disease. However, the prevalence of some diseases, such as allergic rhinitis, cannot be estimated based on the number of patients alone. Specifically, individuals with allergic rhinitis typically self-medicate by taking over-the-counter (OTC) medications without going to the hospital. Although allergic rhinitis is not a life-threatening disease, it represents a major social problem because it reduces people’s quality of life, making it essential to understand its prevalence and people’s motives for self-medication behavior. Objective: This study aims to explore the relationship between the number of social media posts mentioning the main symptoms of allergic rhinitis and the sales volume of OTC rhinitis medications in Japan. Methods: We collected tweets over 4 years (from 2017 to 2020) that included keywords corresponding to the main nasal symptoms of allergic rhinitis: “sneezing,” “runny nose,” and “stuffy nose.” We also obtained the sales volume of OTC drugs, including oral medications and nasal sprays, for the same period. We then calculated the Pearson correlation coefficient between time series data on the number of tweets per week and time series data on the sales volume of OTC drugs per week. Results: The results showed a much higher correlation (r=0.8432) between the time series data on the number of tweets mentioning “stuffy nose” and the time series data on the sales volume of nasal sprays than for the other two symptoms. There was also a high correlation (r=0.9317) between the seasonal components of these time series data. Conclusions: We investigated the relationships between social media data and behaviora

Published
2023

8. Immune adjuvant therapy using Bacillus Calmette–Guérin cell wall skeleton (BCG-CWS) in advanced malignancies: A phase 1 study of safety and immunogenicity assessments

Author

Nishida, Sumiyuki, Tsuboi, Akihiro, Tanemura, Atsushi, Ito, Toshinori, Nakajima, Hiroko, Shirakata, Toshiaki, Morimoto, Soyoko, Fujiki, Fumihiro, Hosen, Naoki, Oji, Yusuke, Kumanogoh, Atsushi, Kawase, Ichiro, Oka, Yoshihiro, Azuma, Ichiro, Morita, Satoshi, and Sugiyama, Haruo

Published
2019
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11. Exploring Relationships Between Tweet Numbers and Over-the-counter Drug Sales for Allergic Rhinitis: Retrospective Analysis

Author

Wakamiya, Shoko, Morimoto, Osamu, Omichi, Katsuhiro, Hara, Hideyuki, Kawase, Ichiro, Koshiba, Ryuji, Aramaki, Eiji, Wakamiya, Shoko, Morimoto, Osamu, Omichi, Katsuhiro, Hara, Hideyuki, Kawase, Ichiro, Koshiba, Ryuji, and Aramaki, Eiji

Abstract

Background: Health-related social media data are increasingly being used in disease surveillance studies. In particular, surveillance of infectious diseases such as influenza has demonstrated high correlations between the number of social media posts mentioning the disease and the number of patients who went to the hospital and were diagnosed with the disease. However, the prevalence of some diseases, such as allergic rhinitis, cannot be estimated based on the number of patients alone. Specifically, individuals with allergic rhinitis typically self-medicate by taking over-the-counter (OTC) medications without going to the hospital. Although allergic rhinitis is not a life-threatening disease, it represents a major social problem because it reduces people’s quality of life, making it essential to understand its prevalence and people’s motives for self-medication behavior. Objective: This study aims to explore the relationship between the number of social media posts mentioning the main symptoms of allergic rhinitis and the sales volume of OTC rhinitis medications in Japan. Methods: We collected tweets over 4 years (from 2017 to 2020) that included keywords corresponding to the main nasal symptoms of allergic rhinitis: “sneezing,” “runny nose,” and “stuffy nose.” We also obtained the sales volume of OTC drugs, including oral medications and nasal sprays, for the same period. We then calculated the Pearson correlation coefficient between time series data on the number of tweets per week and time series data on the sales volume of OTC drugs per week. Results: The results showed a much higher correlation (r=0.8432) between the time series data on the number of tweets mentioning “stuffy nose” and the time series data on the sales volume of nasal sprays than for the other two symptoms. There was also a high correlation (r=0.9317) between the seasonal components of these time series data. Conclusions: We investigated the relationships between social media data and behaviora, identifier:2561-326X

Published
2022

13. Stratification of Malignant Pleural Mesothelioma Prognosis Using Recursive Partitioning Analysis

Author

Suzuki, Hidekazu, Asami, Kazuhiro, Hirashima, Tomonori, Okamoto, Norio, Yamadori, Tadahiro, Tamiya, Motohiro, Morishita, Naoko, Shiroyama, Takayuki, Takeoka, Sawa, Osa, Akio, Azuma, Yuichiro, Okishio, Kyoichi, Kawaguchi, Tomoya, Atagi, Shinji, and Kawase, Ichiro

Subjects
Mesothelioma -- Research -- Risk factors -- Development and progression -- Care and treatment -- Prognosis, Chest pain -- Risk factors -- Research, Allergy -- Research -- Risk factors, Health
Abstract

Purpose Prognostic factors and complicated prognostic models have been proposed for malignant pleural mesothelioma (MPM). This study was designed to stratify MPM prognosis by using a simple model. Methods Patients diagnosed with MPM in the past 10 years (n = 122) were examined retrospectively. Data on the presence of chest pain, performance status (PS), asbestos exposure, smoking status, white blood cell count (WBC), haemoglobin (Hb) concentration, platelet count (PLT), lactate dehydronate (LD), histology, stage, and date of death or censored status were collected. After the factors were examined in the univariate analysis, recursive partitioning analysis was performed. Results Statistically significant factors related to survival were the type of histology, stage, PS, WBC, PLT, Hb concentration, and LD. Histology, stage, PS, and Hb concentration were used in multivariate analysis. Stage and Hb concentration showed good statistical significance, whereas PS was borderline significant. The survival analyses were stratified into five groups by PS, stage, Hb concentration, and chest pain using recursive partitioning analysis. Group A comprised patients showing the most favourable prognoses (PS 0-2 and Hb concentration >12.1 g dL.sup.-1 or PS 0-2 and Hb concentration [less than or equal to]12.1 g dL.sup.-1 without pain), and group B comprised the remaining patients. The median overall survival in groups A and B was 563 days (95 % confidence interval [CI] 502-779) and 157 days (95 % CI 115-224), respectively (hazard ratio of 5.44 [3.46-8.53, P < 0.0001]). Conclusions The MPM patients with PS 0-2 and Hb concentration >12.1 or [less than or equal to]12.1 g dL.sup.-1 without chest pain had favourable prognoses., Author(s): Hidekazu Suzuki[sup.1] , Kazuhiro Asami[sup.2] , Tomonori Hirashima[sup.1] , Norio Okamoto[sup.1] , Tadahiro Yamadori[sup.1] , Motohiro Tamiya[sup.1] , Naoko Morishita[sup.1] , Takayuki Shiroyama[sup.1] , Sawa Takeoka[sup.1] , Akio Osa[sup.1] [...]

Published
2014
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20. NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: A randomized controlled trial for pharmacogenetics-based therapy

Author

Azuma, Junichi, Ohno, Masako, Kubota, Ryuji, Yokota, Soichiro, Nagai, Takayuki, Tsuyuguchi, Kazunari, Okuda, Yasuhisa, Takashima, Tetsuya, Kamimura, Sayaka, Fujio, Yasushi, Kawase, Ichiro, and Pharmacogenetics-based tuberculosis therapy research group

Published
2013
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33. Wilms Tumor gene WT1 peptide-based immunotherapy induced a minimal response in a patient with advanced therapy-resistant multiple myeloma

Author

Tsuboi, Akihiro, Oka, Yoshihiro, Nakajima, Hiroko, Fukuda, Yoko, Elisseeva, Olga A., Yoshihara, Satoshi, Hosen, Naoki, Ogata, Atsushi, Kito, Katsuyuki, Fujiki, Fumihiro, Nishida, Sumiyuki, Shirakata, Toshiaki, Ohno, Satoshi, Yasukawa, Masaki, Oji, Yusuke, Kawakami, Manabu, Morita, Satoshi, Sakamoto, Junichi, Udaka, Keiko, Kawase, Ichiro, and Sugiyama, Haruo

Published
2007
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45. WT1 peptide vaccination combined with BCG-CWS is more efficient for tumor eradication than WT1 peptide vaccination alone

Author

Nakajima, Hiroko, Kawasaki, Kotomi, Oka, Yoshihiro, Tsuboi, Akihiro, Kawakami, Manabu, Ikegame, Kazuhiro, Hoshida, Yoshihiko, Fujiki, Fumihiro, Nakano, Akiko, Masuda, Tomoki, Wu, Fei, Taniguchi, Yuki, Yoshihara, Satoshi, Elisseeva, Olga A., Oji, Yusuke, Ogawa, Hiroyasu, Azuma, Ichiro, Kawase, Ichiro, Aozasa, Katsuyuki, and Sugiyama, Haruo

Published
2004
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46. Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT

Author

Kimura, Akihiro, Naka, Tetsuji, Muta, Tatsushi, Takeuchi, Osamu, Akira, Shizuo, Kawase, Ichiro, and Kishimoto, Tadamitsu

Subjects
Immunosuppressive agents -- Research, Science and technology
Abstract

Suppressor of cytokine signaling-1 (SOCS-1) is one of the negative-feedback regulators of Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling. We previously showed that SOCS-1 participates in LPS signaling, but it is not entirely clear yet how SOCS-1 suppresses LPS signaling. In this study, we demonstrate that SOCS-1 selectively inhibits LPS-induced IL-6 production through regulation of JAK-STAT but not production of TNF-[alpha], granulocyte colony-stimulating factor, IFN-[beta], and other cytokines. We found that LPS directly activated Jak2 and Stat5, whereas SOCS-1 inhibited LPS-induced Jak2 and Stat5 activation. Furthermore, AG490, a Jak-specific inhibitor, and dominant negative Stat5 only reduced LPS-induced IL-6 production. Additionally, Stat5 interacted with p50, resulting in recruitment of Stats to the IL-6 promoter together with p50 in response to LPS stimulation. These findings suggest that the JAK-STAT pathway participates in LPS-induced IL-6 production and that SOCS-1 suppresses LPS signaling by regulating JAK-STAT. innate immunity | Jak2 | Stat5 | Toll-like receptor signal

Published
2005

47. Protective effect of IL-6 on alveolar epithelial cell death induced by hydrogen peroxide

Author

Kida, Hiroshi, Yoshida, Mitsuhiro, Hoshino, Shigenori, Inoue, Koji, Yano, Yukihiro, Yanagita, Masahiko, Kumagai, Toru, Osaki, Tadashi, Tachibana, Isao, Saeki, Yukihiko, and Kawase, Ichiro

Subjects
Oxidative stress, Interleukins, Hydrogen peroxide, Apoptosis, Biological sciences
Abstract

The goal of this study was to examine whether IL-6 could directly protect lung resident cells, especially alveolar epithelial cells, from reactive oxygen species (ROS)-induced cell death. ROS induced IL-6 gene expression in organotypic lung slices of wild-type (WT) mice. ROS also induced IL-6 gene expression in mouse primary lung fibroblasts, dose dependently. The organotypic lung slices of WT were more resistant to ROS-induced DNA fragmentation than those of IL-6-deficient (IL-6-/-) mice. WT resistance against ROS was abrogated by treatment with anti-IL-6 antibody. TdT-mediated dUTP nick end labeling stain and electron microscopy revealed that DNA fragmented cells in the IL-6-/- slice included alveolar epithelial cells and endothelial cells. In vitro studies demonstrated that IL-6 reduced ROS-induced A549 alveolar epithelial cell death. Together, these data suggest that IL-6 played an antioxidant role in the lung by protecting lung resident cells, especially alveolar epithelial cells, from ROS-induced cell death. lung slice culture; oxidative stress; diffuse alveolar damage; apoptosis; interleukin-6

Published
2005

48. Monitoring Minimal Residual Disease in Leukemia Using Real-time Quantitative Polymerase Chain Reaction for Wilms Tumor Gene (WT1)

Author

Tamaki, Hiroya, Mishima, Machiko, Kawakami, Manabu, Tsuboi, Akihiro, Kim, Eui Ho, Hosen, Naoki, Ikegame, Kazuhiro, Murakami, Masaki, Fujioka, Tatsuya, Masuda, Tomoki, Taniguchi, Yuki, Nishida, Sumiyuki, Osumi, Kazuoki, Soma, Toshihiro, Oji, Yusuke, Oka, Yoshihiro, Kawase, Ichiro, Sugiyama, Haruo, and Ogawa, Hiroyasu

Published
2003
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49. The lck Promoter-Driven Expression of the Wilms Tumor Gene WT1 Blocks Intrathymic Differentiation of T-Lineage Cells

Author

Li, Hanfen, Oka, Yoshihiro, Tsuboi, Akihiro, Yamagami, Tamotsu, Miyazaki, Toru, Yusa, Sei-ichi, Kawasaki, Kotomi, Kishimoto, Yukiko, Asada, Momotaro, Nakajima, Hiroko, Kanato, Keisuke, Nishida, Sumiyuki, Masuda, Tomoki, Murakami, Masaki, Hosen, Naoki, Kawakami, Manabu, Ogawa, Hiroyasu, Melchers, Fritz, Kawase, Ichiro, Oji, Yusuke, and Sugiyama, Haruo

Published
2003
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