Recently, concerns have been growing about the intensification and increase in extreme weather events, including torrential rainfall and typhoons. For mitigating the damage caused by weather-induced disasters, recent studies have started developing weather control technologies to lead the weather to a desirable direction with feasible manipulations. This study proposes introducing the model predictive control (MPC), an advanced control method explored in control engineering, into the framework of the control simulation experiment (CSE). In contrast to previous CSE studies, the proposed method explicitly considers physical constraints, such as the maximum allowable manipulations, within the cost function of the MPC. As the first step toward applying the MPC to real weather control, this study performed a series of MPC experiments with the Lorenz 63 model. Our results showed that the Lorenz 63 system can be led to the positive regime with control inputs determined by the MPC. Furthermore, the MPC significantly reduced necessary forecast length compared to earlier CSE studies. It was beneficial to select a member that showed a larger regime shift for the initial state when dealing with uncertainty in initial states. [ABSTRACT FROM AUTHOR]