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804 results on '"Kawano, Hirotaka"'

14. The role of chemotherapy and radiotherapy in localized extraskeletal osteosarcoma

Author

Heng, Marilyn, Gupta, Abha, Chung, Peter W, Healey, John H, Vaynrub, Max, Rose, Peter S, Houdek, Matthew T, Lin, Patrick P, Bishop, Andrew J, Hornicek, Francis J, Chen, Yen-Lin, Lozano-Calderon, Santiago, Holt, Ginger E, Han, Ilkyu, Biau, David, Niu, Xiaohui, Bernthal, Nicholas M, Ferguson, Peter C, Wunder, Jay S, Group, Japanese Musculoskeletal Oncology, Ueda, Takafumi, Kakunaga, Shigeki, Kawai, Akira, Sugiura, Hideshi, Kidani, Teruki, Kunisasa, Toshiyuki, Ozaki, Toshifumi, Ae, Keisuke, Nagano, Akihito, Ohno, Takatoshi, Hiraoka, Koji, Yamamoto, Norio, Tsuchiya, Hiroyuki, Matsumoto, Yoshihiro, Yanagawa, Takashi, Nakayama, Robart, Morioka, Hideo, Kubo, Tadahiko, Simose, Shoji, Yamagami, Yoshiki, Yamamoto, Tetsuji, Kawasaki, Motohiro, Torigoe, Tomoaki, Yazawa, Yasuo, Akiyama, Toru, Gokita, Tabu, Manabe, Jun, Kaya, Mitsunori, Emori, Makoto, Nakamura, Tomoki, Matsumine, Akihiko, Sugihara, Shinsuke, Yokouchi, Masahiro, Komiya, Setsuro, Suehara, Yoshiyuki, Takagi, Tatsuya, Kawamoto, Teruya, Wasa, Junji, Yonemoto, Tsukasa, Ishii, Takeshi, Baba, Ichiro, Hoshi, Manabu, Hamada, Kenichiro, Naka, Norifumi, Sotobori, Tsukasa, Araki, Nobuhito, Okuma, Tomotake, Goto, Takahiro, Kobayashi, Hiroshi, Kawano, Hirotaka, Hosaka, Masami, Futani, Hiroyuki, Hiraga, Hiroaski, Nishida, Yoshihiro, Collaborative, Soft Tissue Osteosarcoma International, Griffin, Anthony, Razak, Albiruni R Abdul, Shultz, David Benjamin, Catton, Charles, Robinson, Steven, Patel, Shreyaskumar R, Lewis, Valerae O, Guadagnolo, B Ashleigh, DeLaney, Thomas, Wang, Haotong, Raskin, Kevin, Callan, Alexandra K, Henshaw, Robert, Isler, Marc, Mottard, Sophie, Chen, Wei-Ming, Traub, Frank, Chen, Tom Wei-Wu, Turcotte, Robert E, Davidson, Darin, Tunn, Per-Ulf, Loong, Herbert, Ghert, Michelle, Werier, Joel, and Clarkson, Paul

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Patient Safety, Clinical Research, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Osteosarcoma, Prognosis, Retrospective Studies, Risk Factors, Survival Analysis, Young Adult, Extraskeletal osteosarcoma, Soft-tissue osteosarcoma, Chemotherapy, Radiotherapy, Radiation therapy, Japanese Musculoskeletal Oncology Group, Soft Tissue Osteosarcoma International Collaborative, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

PurposeThe role of chemotherapy (CT) and radiotherapy (RT) for management of extraskeletal osteosarcoma (ESOS) remains controversial. We examined disease outcomes for ESOS patients and investigated the association between CT/RT with recurrence and survival.Patients and methodsRetrospective review at 25 international sarcoma centers identified patients ≥18 years old treated for ESOS from 1971 to 2016. Patient/tumour characteristics, treatment, local/systemic recurrence, and survival data were collected. Kaplan-Meier survival and Cox proportional-hazards regression and cumulative incidence competing risks analysis were performed.Results370 patients with localized ESOS treated definitively with surgery presented with mainly deep tumours (n = 294, 80%). 122 patients underwent surgical resection alone, 96 (26%) also received CT, 70 (19%) RT and 82 (22%) both adjuvants. Five-year survival for patients with localized ESOS was 56% (95% CI 51%-62%). Almost half of patients (n = 173, 47%) developed recurrence: local 9% (35/370), distant 28% (102/370) or both 10% (36/370). Considering death as a competing event, there was no significant difference in cumulative incidence of local or systemic recurrence between patients who received CT, RT, both or neither (local p = 0.50, systemic p = 0.69). Multiple regression Cox analysis showed a significant association between RT and decreased local recurrence (HR 0.46 [95% CI 0.26-0.80], p = 0.01).ConclusionAlthough the use of RT significantly decreased local recurrences, CT did not decrease the risk of systemic recurrence, and neither CT, nor RT nor both were associated with improved survival in patients with localized ESOS. Our results do not support the use of CT; however, adjuvant RT demonstrates benefit in patients with locally resectable ESOS.

Published
2020

16. Dedifferentiated liposarcoma in the extremity and trunk wall: A multi-institutional study of 132 cases by the Japanese Musculoskeletal Oncology Group (JMOG)

Author

Morii, Takeshi, Anazawa, Ukei, Sato, Chiaki, Iwata, Shintaro, Nakagawa, Makoto, Endo, Makoto, Nakamura, Tomoki, Ikuta, Kunihiro, Nishida, Yoshihiro, Nakayama, Robert, Udaka, Toru, Kawamoto, Teruya, Kito, Munehisa, Sato, Kenji, Imanishi, Jungo, Akiyama, Toru, Kobayashi, Hiroshi, Nagano, Akihito, Outani, Hidetatsu, Toki, Shunichi, Nishisho, Toshihiko, Sasa, Keita, Suehara, Yoshiyuki, Kawano, Hirotaka, Ueda, Takafumi, and Morioka, Hideo

Published
2023
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23. Kinematic Alignment Achieves a More Balanced Total Knee Arthroplasty Than Mechanical Alignment among CPAK Type I Patients: A Simulation Study.

Author

Arai, Noriaki, Toyooka, Seikai, Masuda, Hironari, Kawano, Hirotaka, and Nakagawa, Takumi

Subjects
TOTAL knee replacement, ANATOMICAL planes, PATELLA, TOTAL shoulder replacement
Abstract

Background: There is no consensus on whether mechanical alignment (MA) or kinematic alignment (KA) should be chosen for total knee arthroplasty (TKA) for coronal plane alignment of the knee (CPAK) Type I with a varus arithmetic HKA (aHKA) and apex distal joint line obliquity (JLO). The aim of this study was to investigate whether MA or KA is preferable for soft tissue balancing in TKA for this phenotype. Method: This prospective cohort study included 64 knees with CPAK Type I osteoarthritis that had undergone cruciate-retaining TKA. Using optical tracking software, we simulated implant placement in the Mako system before making the actual bone cut and compared the results between MA and KA. Extension balance (the difference between medial and lateral gaps in extension) and medial balance (the difference in medial gaps in flexion and extension) were examined. These gap differences within 2 mm were defined as good balance. Achievement of overall balance was defined as an attainment of good extension and medial balance. The incidence of balance in each patient was compared with an independent sample ratio test. Results: Compared with the MA group, the KA group achieved better soft tissue balance in extension balance (p < 0.001). A total of 75% of the patients in the KA group achieved overall balance, which was greater than the 38% achieved in the MA group (p < 0.001). Conclusions: In robot-assisted TKA for CPAK Type I osteoarthritis, KA achieved knee balance during extension without soft tissue release in a greater percentage of patients than MA. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Brain Masculinization Requires Androgen Receptor Function

Author

Sato, Takashi, Matsumoto, Takahiro, Kawano, Hirotaka, Watanabe, Tomoyuki, Uematsu, Yoshikatsu, Sekine, Keisuke, Fukuda, Toru, Aihara, Ken-ichi, Krust, Andrée, Yamada, Takashi, Nakamichi, Yuko, Yamamoto, Yoko, Nakamura, Takashi, Yoshimura, Kimihiro, Yoshizawa, Tatsuya, Metzger, Daniel, Chambon, Pierre, and Kato, Shigeaki

Published
2004

38. Risk Factors for Dural Tears in Spinal Surgery: A Prospective Multicenter Registry Study of 1,698 Cases

Author

Hirahata, Masahiro, primary, Fujita, Muneyoshi, additional, Inui, Takahiro, additional, Ishii, Keisuke, additional, Takekawa, Tatsuhisa, additional, Iwai, Hiroki, additional, Murata, Yasuaki, additional, Yamada, Kazuaki, additional, Shiboi, Ryutaro, additional, Yonezawa, Keisuke, additional, Iwahori, Tomoyuki, additional, Iimuro, Satoshi, additional, Fujita, Retsu, additional, Kawano, Hirotaka, additional, and Kitagawa, Tomoaki, additional

Published
2023
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39. Suppressive Function of Androgen Receptor in Bone Resorption

Author

Kawano, Hirotaka, Sato, Takashi, Yamada, Takashi, Matsumoto, Takahiro, Sekine, Keisuke, Watanabe, Tomoyuki, Nakamura, Takashi, Fukuda, Toru, Yoshimura, Kimihiro, Yoshizawa, Tatsuya, Aihara, Ken-ichi, Yamamoto, Yoko, Nakamichi, Yuko, Metzger, Daniel, Chambon, Pierre, Nakamura, Kozo, Kawaguchi, Hiroshi, and Kato, Shigeaki

Published
2003

42. Publisher Correction: Integrated exome and RNA sequencing of dedifferentiated liposarcoma

Author

Hirata, Makoto, Asano, Naofumi, Katayama, Kotoe, Yoshida, Akihiko, Tsuda, Yusuke, Sekimizu, Masaya, Mitani, Sachiyo, Kobayashi, Eisuke, Komiyama, Motokiyo, Fujimoto, Hiroyuki, Goto, Takahiro, Iwamoto, Yukihide, Naka, Norifumi, Iwata, Shintaro, Nishida, Yoshihiro, Hiruma, Toru, Hiraga, Hiroaki, Kawano, Hirotaka, Motoi, Toru, Oda, Yoshinao, Matsubara, Daisuke, Fujita, Masashi, Shibata, Tatsuhiro, Nakagawa, Hidewaki, Nakayama, Robert, Kondo, Tadashi, Imoto, Seiya, Miyano, Satoru, Kawai, Akira, Yamaguchi, Rui, Ichikawa, Hitoshi, and Matsuda, Koichi

Published
2020
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44. Integrated exome and RNA sequencing of dedifferentiated liposarcoma

Author

Hirata, Makoto, Asano, Naofumi, Katayama, Kotoe, Yoshida, Akihiko, Tsuda, Yusuke, Sekimizu, Masaya, Mitani, Sachiyo, Kobayashi, Eisuke, Komiyama, Motokiyo, Fujimoto, Hiroyuki, Goto, Takahiro, Iwamoto, Yukihide, Naka, Norifumi, Iwata, Shintaro, Nishida, Yoshihiro, Hiruma, Toru, Hiraga, Hiroaki, Kawano, Hirotaka, Motoi, Toru, Oda, Yoshinao, Matsubara, Daisuke, Fujita, Masashi, Shibata, Tatsuhiro, Nakagawa, Hidewaki, Nakayama, Robert, Kondo, Tadashi, Imoto, Seiya, Miyano, Satoru, Kawai, Akira, Yamaguchi, Rui, Ichikawa, Hitoshi, and Matsuda, Koichi

Published
2019
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