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22 results on '"Kawamoto, Ikuo"'

3. Atlas of Cynomolgus Macaque Hematopoiesis

Author

Oshima, Shinichiro, primary, Sinha, Rahul, additional, Takeuchi, Kazuhiro, additional, Mizuta, Ken, additional, Nakamura, Tomonori, additional, Ito, Ryoji, additional, Kawamoto, Ikuo, additional, Iwatani, Chizuru, additional, Nakaya, Masataka, additional, Tsuchiya, Hideaki, additional, Bhagat, Shruti, additional, Tsukiyama, Tomoyuki, additional, Takaori-Kondo, Akifumi, additional, Saitou, Mitinori, additional, Murakawa, Yasuhiro, additional, and Yamamoto, Ryo, additional

Published
2024
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4. A new primate model of hypophyseal dysfunction

Author

Kawabata, Teppei, Suga, Hidetaka, Takeuchi, Kazuhito, Nagata, Yuichi, Sakakibara, Mayu, Ushida, Kaori, Ozone, Chikafumi, Enomoto, Atsushi, Kawamoto, Ikuo, Itagaki, Iori, Tsuchiya, Hideaki, Arima, Hiroshi, and Wakabayashi, Toshihiko

Published
2021
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5. Clinical features of irreversible rejection after allogeneic uterus transplantation in cynomolgus macaques

Author

Kisu, Iori, Emoto, Katsura, Masugi, Yohei, Yamada, Yohei, Matsubara, Kentaro, Obara, Hideaki, Matoba, Yusuke, Banno, Kouji, Kato, Yojiro, Saiki, Yoko, Itagaki, Iori, Kawamoto, Ikuo, Iwatani, Chizuru, Murase, Mitsuru, Nakagawa, Takahiro, Tsuchiya, Hideaki, Ishigaki, Hirohito, Urano, Hiroyuki, Ema, Masatsugu, Ogasawara, Kazumasa, Aoki, Daisuke, Nakagawa, Kenshi, and Shiina, Takashi

Published
2020
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6. Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease

Author

Tsukiyama, Tomoyuki, Kobayashi, Kenichi, Nakaya, Masataka, Iwatani, Chizuru, Seita, Yasunari, Tsuchiya, Hideaki, Matsushita, Jun, Kitajima, Kahoru, Kawamoto, Ikuo, Nakagawa, Takahiro, Fukuda, Koji, Iwakiri, Teppei, Izumi, Hiroyuki, Itagaki, Iori, Kume, Shinji, Maegawa, Hiroshi, Nishinakamura, Ryuichi, Nishio, Saori, Nakamura, Shinichiro, Kawauchi, Akihiro, and Ema, Masatsugu

Published
2019
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9. Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys

Author

40909503, 90648429, 30535836, 50391892, Mizuta, Ken, Katou, Yoshitaka, Nakakita, Baku, Kishine, Aoi, Nosaka, Yoshiaki, Saito, Saki, Iwatani, Chizuru, Tsuchiya, Hideaki, Kawamoto, Ikuo, Nakaya, Masataka, Tsukiyama, Tomoyuki, Nagano, Masahiro, Kojima, Yoji, Nakamura, Tomonori, Yabuta, Yukihiro, Horie, Akihito, Mandai, Masaki, Ohta, Hiroshi, Saitou, Mitinori, 40909503, 90648429, 30535836, 50391892, Mizuta, Ken, Katou, Yoshitaka, Nakakita, Baku, Kishine, Aoi, Nosaka, Yoshiaki, Saito, Saki, Iwatani, Chizuru, Tsuchiya, Hideaki, Kawamoto, Ikuo, Nakaya, Masataka, Tsukiyama, Tomoyuki, Nagano, Masahiro, Kojima, Yoji, Nakamura, Tomonori, Yabuta, Yukihiro, Horie, Akihito, Mandai, Masaki, Ohta, Hiroshi, and Saitou, Mitinori

Abstract

In vitro oogenesis is key to elucidating the mechanism of human female germ-cell development and its anomalies. Accordingly, pluripotent stem cells have been induced into primordial germ cell-like cells and into oogonia with epigenetic reprogramming, yet further reconstitutions remain a challenge. Here, we demonstrate ex vivo reconstitution of fetal oocyte development in both humans and cynomolgus monkeys (Macaca fascicularis). With an optimized culture of fetal ovary reaggregates over three months, human and monkey oogonia enter and complete the first meiotic prophase to differentiate into diplotene oocytes that form primordial follicles, the source for oogenesis in adults. The cytological and transcriptomic progressions of fetal oocyte development in vitro closely recapitulate those in vivo. A comparison of single-cell transcriptomes among humans, monkeys, and mice unravels primate-specific and conserved programs driving fetal oocyte development, the former including a distinct transcriptomic transformation upon oogonia-to-oocyte transition and the latter including two active X chromosomes with little X-chromosome upregulation. Our study provides a critical step forward for realizing human in vitro oogenesis and uncovers salient characteristics of fetal oocyte development in primates.

Published
2022

11. First Successful Delivery after Uterus Transplantation in MHC-Defined Cynomolgus Macaques

Author

Kisu, Iori, primary, Kato, Yojiro, additional, Masugi, Yohei, additional, Ishigaki, Hirohito, additional, Yamada, Yohei, additional, Matsubara, Kentaro, additional, Obara, Hideaki, additional, Emoto, Katsura, additional, Matoba, Yusuke, additional, Adachi, Masataka, additional, Banno, Kouji, additional, Saiki, Yoko, additional, Sasamura, Takako, additional, Itagaki, Iori, additional, Kawamoto, Ikuo, additional, Iwatani, Chizuru, additional, Nakagawa, Takahiro, additional, Murase, Mitsuru, additional, Tsuchiya, Hideaki, additional, Urano, Hiroyuki, additional, Ema, Masatsugu, additional, Ogasawara, Kazumasa, additional, Aoki, Daisuke, additional, Nakagawa, Kenshi, additional, and Shiina, Takashi, additional

Published
2020
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12. Experimental techniques for the development of a uterus transplantation model in cynomolgus macaques

Author

Kisu, Iori, primary, Banno, Kouji, additional, Obara, Hideaki, additional, Kato, Yojiro, additional, Yamada, Yohei, additional, Matsubara, Kentaro, additional, Matoba, Yusuke, additional, Adachi, Masataka, additional, Emoto, Katsura, additional, Masugi, Yohei, additional, Saiki, Yoko, additional, Ishigaki, Hirohito, additional, Itagaki, Iori, additional, Kawamoto, Ikuo, additional, Iwatani, Chizuru, additional, Nakagawa, Takahiro, additional, Murase, Mitsuru, additional, Tsuchiya, Hideaki, additional, Nakagawa, Kenshi, additional, Shiina, Takashi, additional, and Aoki, Daisuke, additional

Published
2020
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14. Surgical technique for allogeneic uterus transplantation in macaques

Author

Obara, Hideaki, primary, Kisu, Iori, additional, Kato, Yojiro, additional, Yamada, Yohei, additional, Matsubara, Kentaro, additional, Emoto, Katsura, additional, Adachi, Masataka, additional, Matoba, Yusuke, additional, Umene, Kiyoko, additional, Nogami, Yuya, additional, Banno, Kouji, additional, Tsuchiya, Hideaki, additional, Itagaki, Iori, additional, Kawamoto, Ikuo, additional, Nakagawa, Takahiro, additional, Ishigaki, Hirohito, additional, Itoh, Yasushi, additional, Ogasawara, Kazumasa, additional, Saiki, Yoko, additional, Sato, Shin-ichi, additional, Nakagawa, Kenshi, additional, Shiina, Takashi, additional, Aoki, Daisuke, additional, and Kitagawa, Yuko, additional

Published
2016
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15. Evaluation of allowable time and histopathological changes in warm ischemia of the uterus in cynomolgus monkey as a model for uterus transplantation

Author

Adachi, Masataka, primary, Kisu, Iori, additional, Nagai, Toshihiro, additional, Emoto, Katsura, additional, Banno, Kouji, additional, Umene, Kiyoko, additional, Nogami, Yuya, additional, Tsuchiya, Hideaki, additional, Itagaki, Iori, additional, Kawamoto, Ikuo, additional, Nakagawa, Takahiro, additional, Ogasawara, Kazumasa, additional, and Aoki, Daisuke, additional

Published
2016
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16. Study of Pharmacokinetic Properties of Cyclosporine A after Subcutaneous Injection in Cynomolgus Monkey

Author

Kisu, Iori, primary, Kato, Yojiro, additional, Tsuchiya, Hideaki, additional, Kawamoto, Ikuo, additional, Nakagawa, Takahiro, additional, Ogasawara, Kazumasa, additional, Hayakawa, Tomohisa, additional, Yamayoshi, Yasuko, additional, Iketani, Osamu, additional, Mihara, Makoto, additional, Banno, Kouji, additional, Sato, Shin-ichi, additional, Shiina, Takashi, additional, and Aoki, Daisuke, additional

Published
2014
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20. Long-Term Outcome and Rejection After Allogeneic Uterus Transplantation in Cynomolgus Macaques.

Author

Kisu, Iori, Ishigaki, Hirohito, Emoto, Katsura, Kato, Yojiro, Yamada, Yohei, Matsubara, Kentaro, Obara, Hideaki, Masugi, Yohei, Matoba, Yusuke, Adachi, Masataka, Banno, Kouji, Saiki, Yoko, Itagaki, Iori, Kawamoto, Ikuo, Iwatani, Chizuru, Nakagawa, Takahiro, Tsuchiya, Hideaki, Sasamura, Takako, Urano, Hiroyuki, and Ema, Masatsugu

Subjects
MACAQUES, UTERUS, IMMUNOSUPPRESSION, TRANSPLANTATION of organs, tissues, etc., KILLER cells, LYMPHOPROLIFERATIVE disorders, LYMPHOCYTE count
Abstract

Uterus transplantation (UTx) is an option for women with uterine factor infertility to have a child, but is still in the experimental stage. Therefore, allogeneic animal models of UTx are required for resolution of clinical issues. In this study, long-term outcomes were evaluated in four recipients (cases 1–4) after allogeneic UTx in cynomolgus macaques. Immunosuppression with antithymocyte globulin induction and a triple maintenance regimen was used. Postoperative ultrasonography and biopsy of the transplanted uterus and immunoserological examinations were performed. All four recipients survived for >3 months after surgery, but continuous menstruation did not resume, although temporary menstruation occurred (cases 1 and 2). All animals were euthanized due to irreversible rejection and no uterine blood flow (cases 1, 2 and 4) and post-transplant lymphoproliferative disorder (case 3). Donor-specific antibodies against MHC class I and II were detected in cases 1, 2 and 4, but not in case 3. Peripheral lymphocyte counts tended to elevate for CD3+, CD20+ and NK cells in conjunction with uterine rejection, and all animals had elevated stimulation indexes of mixed lymphocyte reaction after surgery. Establishment of allogeneic UTx in cynomolgus macaque requires further exploration of immunosuppression, but the clinicopathological features of uterine rejection are useful for development of human UTx. [ABSTRACT FROM AUTHOR]

Published
2019
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22. Duration of Vascular Endothelial Growth Factor Suppression after Intravitreal Injection of Faricimab in Macaque Eyes.

Author

Matsumoto R, Obata S, Kakinoki M, Sawada O, Kawamoto I, Murase M, and Ohji M

Abstract

Purpose: To evaluate the duration of vascular endothelial growth factor (VEGF) suppression in the aqueous humor of macaque eyes after intravitreal faricimab (IVF) injection. Methods: Faricimab (6 mg/50 µL) was injected into the vitreous cavity of the right eye of 6 macaques. Aqueous humor samples (150 μL) were collected from both eyes immediately before injection and on days 1, 3, 7, 14, 21, 28, 42, 56, 84, and 112 after injection. The VEGF concentrations in the aqueous humor were measured using an enzyme-linked immunosorbent assay. Results: The VEGF was undetectable until 4 weeks after IVF injection in 4 eyes and until 6 weeks in the remaining 2 eyes. The mean duration of complete VEGF suppression was 4.7 weeks (range, 4-6 weeks). The VEGF concentration did not decrease in the aqueous humor of the non-injected fellow eyes. Conclusions: Faricimab effectively suppressed the VEGF concentrations in the aqueous humor of macaques for an average of 4.7 weeks after a single intravitreal injection. It did not reduce the VEGF concentrations in the aqueous humor of the fellow eyes.

Published
2024
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