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The isotope-production cross sections in p- and d-induced reactions on 93Zr at approximately 50 MeV/nucleon were measured by using the inverse-kinematics method at RIKEN RI Beam Factory. The measured data were compared with the previous experimental 93Zr + p, d at 105 and 209 MeV/nucleon data. This comparison represents that the isotopic distribution of production cross sections at 51 MeV p-induced reaction is appreciably different from those at 105 and 209 MeV. On the other hand, these three data sets show that the shape of isotopic distribution is similar in the case of the d-induced reaction. Also, the measured production cross sections were compared with the theoretical model calculations with Particle and Heavy Ion Transport code System (PHITS) version 3.10 in order to investigate the reproducibility of the models implemented in PHITS. The calculations well reproduced the experimental data even in such low incident energy, while several discrepancies were still seen as in the p- and d-induced reactions at 105 and 209 MeV/nucleon.

Spallation reaction for the long-lived fission product 107Pd has been studied for the purpose of nuclear waste transmutation. The isotopic-distribution cross sections on both proton and deuteron were obtained at 118 MeV/nucleon in inverse kinematics at the RIKEN Radioactive Isotope Beam Factory. A large cross-section difference was found between the proton and deuteron results for the light-mass products. The data were compared with the SPACS semi-empirical parameterization and the PHITS calculations including both the intranuclear cascade and evaporation processes. In addition, the potential of spallation reaction for transmutation of 107Pd is discussed.

Isotopic production cross sections were measured for proton- and deuteron-induced reactions on 93Nb by means of the inverse kinematics method at RIKEN Radioactive Isotope Beam Factory. The measured production cross sections of residual nuclei in the reaction 93Nb + p at 113 MeV/u were compared with previous data measured by the conventional activation method in the proton energy range between 46 and 249 MeV. The present inverse kinematics data of four reaction products (90Mo, 90Nb, 88Y, and 86Y) were in good agreement with the data of activation measurement. Also, the model calculations with PHITS describing the intra-nuclear cascade and evaporation processes generally well reproduced the measured isotopic production cross sections.

Isotopic production cross sections in the proton- and deuteron-induced spallation reactions on 93Zr at an energy of 105 MeV/u were measured in inverse kinematics conditions for the development of realistic nuclear transmutation processes for long-lived fission products (LLFPs) with neutron and light-ion beams. The experimental results were compared to the PHITS calculations describing the intra-nuclear cascade and evaporation processes. Although an overall agreement was obtained, a large overestimation of the production cross sections for the removal of a few nucleons was seen. A clear shell effect associated with the neutron magic number N = 50 was observed in the measured isotopic production yields of Zr and Y isotopes, which can be reproduced reasonably by the PHITS calculation.

Spallation reactions for the long-lived fission products 137Cs, 90Sr and 107Pd have been studied for the purpose of nuclear waste transmutation. The cross sections on the proton- and deuteron-induced spallation were obtained in inverse kinematics at the RIKEN Radioactive Isotope Beam Factory. Both the target and energy dependences of cross sections have been investigated systematically. and the cross-section differences between the proton and deuteron are found to be larger for lighter fragments. The experimental data are compared with the SPACS semi-empirical parameterization and the PHITS calculations including both the intra-nuclear cascade and evaporation processes.

Systematic reviews showed possible esthetic complications with the use of traditional flap designs after guided bone regeneration (GBR) procedures in the esthetic zone and the aim of this case series was to analyze hard and soft tissue changes over 18 months after these procedures. Healthy subjects requiring tooth extraction and single-implant placement in the anterior maxilla were enrolled in the study. Three months after tooth extraction and ridge preservation, a prosthetic-driven implant was placed. The horizontal bone deficiency was treated with a resorbable bone graft substitute (beta tricalcium phosphate [β-TCP]) and a bioresorbable polylactic acid (PLA) membrane. Primary closure was obtained by a novel coronally advanced flap adapted from mucogingival techniques. Final metal-free implant restorations were delivered 4 months after placement. Clinical measurements, pictures, and radiographs were acquired after delivery of the final restoration (T1) and at the 18-month follow-up (T2). Digital impressions were taken at the time of tooth extraction (T-1) and implant insertion (baseline; T0) and at T2. Marginal bone level changes were assessed by radiographic analysis, while soft tissue changes were evaluated with ExoCad software. Student t test for paired data was used to detect differences between the different time points. Twelve subjects (7 men and 5 women; mean age: 63.7 ± 14 years) completed the study and received 15 implants. All implants healed uneventfully and were clinically osseointegrated and stable, showing no sign of infection. No GBR complications were noted. Statistically significant ridge-width changes were observed after extraction (T-1 vs T0 = -1.72 ± 0.30 mm; P = .00001) and after horizontal GBR (T0 vs T2 = 1.41 ± 0.64 mm; P = .00001). Radiographic bone levels after implant placement remained stable T0 to T2 (0.09 ± 0.08 mm). Periodontal parameters never exceeded physiologic levels. It can be concluded that GBR using a bioresorbable PLA membrane and resorbable β-TCP bone graft in conjunction with a coronally advanced flap is a predictable procedure for horizontal bone augmentation with simultaneous implant placement in the esthetic area. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the influence of the height of the antrostomy on dimensional variations of the elevated space after sinus floor elevation. Materials and Methods: Twenty-four healthy volunteers planned for sinus floor elevation were included in the study. An antrostomy of either 4 mm (group A) or 8 mm (group B) in height was prepared in the lateral wall of the sinus. Cone beam computed tomography scans (CBCTs) were taken before surgery (T0) and after 1 week (T1) and 9 months (T2). Dimensional variation analyses were performed. Results: The CBCTs of 10 patients per group were evaluated. After 1 week (T1), the sinus floor was found elevated in the middle region by 12.0 ± 2.3 mm in group A, while in group B, the height was 11.8 ± 2.1 mm. After 9 months (T2), the respective heights were 9.9 ± 2.4 mm and 8.9 ± 2.7 mm, with a reduction of -2.1 ± 2.2 mm in group A and -3.0 ± 2.6 mm in group B. The area in a central position was reduced by 25.5% to 34.2%, showing a slightly higher shrinkage in group B compared with group A. However, no statistically significant differences were found between the two groups. Conclusion: In maxillary sinus floor elevations performed by the lateral approach, the size of the antrostomy did not affect the clinical and radiographic outcomes. [ABSTRACT FROM AUTHOR]

Two research cruises that deployed submersible surveys were undertaken along the Tenryu Submarine Canyon to directly observe the structural architecture of the eastern Nankai Accretionary Prism off the coast of southern Japan. The surveys have demonstrated that the accreted sediments are strongly deformed turbidite sequences that occur in repeated thrust-anticline structures. From the leading edge of the prism near the trench toward the are, the following deformation zones have been identified within the prism: Frontal Thrust zone, Prism Toe zone, Imbricate Thrust zone, and Tokai Thrust zone (or out-of-sequence thrust or OOST zone). The Frontal Thrust zone is characterized by debris deposits within the hanging wall that have an age of 0-0.43 Ma, as determined from radiolarian biostratigraphy. The Prism Toe zone is characterized by unconsolidated turbidite sequences that are 1.98-3.4 Ma; these sequences are cut by normal and thrust faults. The Imbricate Thrust zone includes consolidated muddy layers and unconsolidated sandy layers that contain numerous fracture cleavages. The OOST zone consists of highly deformed consolidated sediments, ranging in age from 0.18 to 1.03 Ma. From the Prism Toe zone to the Imbricate Thrust zone, the uniaxial compressive strength increases gradually from 0.53.0 to 1.0-6.0 MPa, while the anisotropy of magnetic susceptibility changes from oblate to prolate shapes, and porosity decreases from 40%-50% to 30%-50%. These data indicate that the eastern Nankai Accretionary Prism appears to have been deformed toward the Imbricate Thrust zone just south of the OOST. Stable isotope analyses of calcite veins and calcite cement of the sandstone samples from the Tokai Thrust zone have shown that fluid temperatures for calcite precipitation were 24-63 [degrees]C in the OOST zone. The occurrence of highly deformed and consolidated rocks within the Nankai Accretionary Prism likely resulted from tectonic transportation of deeply buried rocks along major out-of-sequence thrust faults, such as the Tokai OOST. We infer therefore that out-of-sequence thrust faults play a major role in transporting deeply buried, deformed rocks in accretionary prisms to the shallower depths and even to the seafloor during ongoing subduction.

Aim: The aim of the present study was to evaluate dimensional variations of augmented sinus volumes after sinus floor elevation using a lateral approach placing the antrostomy close to the sinus floor or more cranially to it., Methods: Twenty-four healthy volunteers in need of sinus floor elevation were included in the study. The lateral approach was adopted placing the antrostomy randomly either close to the level of the sinus floor (group A) or approximately 3-4 mm cranially (group B). Cone-beam computed tomography (CBCT) was done before surgery (T0) and after 1 week (T1) and 9 months (T2), and analyses on dimensional variations were performed., Results: CBCT of 10 patients per group were analyzed. At T1, the sinus floor was found to be elevated by 9.8 ± 2.1 mm in group A and 10.9 ± 1.9 mm in group B. At T2, shrinkage of 2.0 ± 1.7 mm in group A and 1.4 ± 2.5 mm in group B was observed. The area was reduced approximately 18-24% between T1 and T2. The sinus mucosa width increased by 4.3-5 mm between T0 and T1, and regained the original dimensions at T2., Conclusions: The more cranial the antrostomy, the greater the augmentation height after 9 months., (© 2018 John Wiley & Sons Australia, Ltd.)

Apoptosis and angiogenesis are critical biologic processes that are altered during carcinogenesis. Both apoptosis and angiogenesis may play an important role in pancreatic carcinogenesis. Despite numerous advances in the diagnosis and treatment of pancreatic cancer, its prognosis remains dismal and a new therapeutic approach is much needed. Recent research has revealed that apoptosis and angiogenesis are closely interrelated. Several reports show that a tumor suppresser gene that is expressed in pancreatic carcinoma and related to malignant potential can induce apoptosis and also inhibit angiogenesis. At present, it is generally accepted that tumor growth in cancers, including pancreatic cancer, depends on angiogenesis. We have identified 2 new angiogenesis inhibitors from a conditioned medium of human pancreatic carcinoma cell line (BxPC-3): antiangiogenic antithrombin III (aaAT-III) and vitamin D binding protein-macrophage activating factor (DBP-maf). These molecules were able to regress tumors in severe combined immunodeficiency disease (SCID) mice, demonstrating potent inhibition of endothelial cell proliferation. Moreover, the angiogenesis inhibitors induced tumor dormancy in the animal model. These results suggest that antiangiogenic therapy using angiogenesis inhibitors may become a new strategy for treatment of pancreatic cancer in the near future.