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5. Precise healing of oral and maxillofacial wounds: tissue engineering strategies and their associated mechanisms

Author

Qingtong Zhao, Changyun Leng, Manting Lau, Kawai Choi, Ruimin Wang, Yuyu Zeng, Taiying Chen, Canyu Zhang, and Zejian Li

Subjects
wound healing, tissue engineering, hydrogel, nanofibers, tissue repair, Biotechnology, TP248.13-248.65
Abstract

Precise healing of wounds in the oral and maxillofacial regions is usually achieved by targeting the entire healing process. The rich blood circulation in the oral and maxillofacial regions promotes the rapid healing of wounds through the action of various growth factors. Correspondingly, their tissue engineering can aid in preventing wound infections, accelerate angiogenesis, and enhance the proliferation and migration of tissue cells during wound healing. Recent years, have witnessed an increase in the number of researchers focusing on tissue engineering, particularly for precise wound healing. In this context, hydrogels, which possess a soft viscoelastic nature and demonstrate exceptional biocompatibility and biodegradability, have emerged as the current research hotspot. Additionally, nanofibers, films, and foam sponges have been explored as some of the most viable materials for wound healing, with noted advantages and drawbacks. Accordingly, future research is highly likely to explore the application of these materials harboring enhanced mechanical properties, reduced susceptibility to external mechanical disturbances, and commendable water absorption and non-expansion attributes, for superior wound healing.

Published
2024
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10. Magnetoliposomes as model for signal transmission

Author

Barreto, G. R., primary, Kawai, C., additional, Tofanello, A., additional, Neves, A. A. R., additional, Araujo-Chaves, J. C., additional, Belleti, E., additional, Lanfredi, A. J. C., additional, Crespilho, F. N., additional, and Nantes-Cardoso, I. L., additional

Published
2019
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13. Deverbální jmenné predikáty v konstrukcích se slovesem dělat v češtině z mezijazykové perspektivy

Author

Melissa Shih-hui Lin, Karel Šebesta, Kawai Chui, and Hsiang-lin Yeh

Subjects
do-construction, light verb, czech, chinese, russian, Philology. Linguistics, P1-1091
Abstract

This study introduces a cross-linguistic investigation of Do-constructions in Chinese, Russian and Czech, focusing especially on Do-construction strategies in Czech. The DO-construction in this study refers to a predicate-argument structure comprising the light verb ‘to do’, and a predicate deverbal noun, which is a noun derived from a verb or verbal phrase. Chinese, Russian and Czech align in manifesting a cross-language functional construal where predication rests upon the semantic content of the accusative argument denoting action events that are of interest in communication. A corpus analysis of the linguistic properties of the constructions across speaking and writing attested that Do-constructions in Chinese are more productive than those of Russian and Czech. However, the corpus data also show that the light uses of the Czech verb ‘to do’ are predominant compared with its full uses. Therefore, this study further focuses on one of the light uses of the Czech verb ‘to do’, which is with predicate deverbal nouns.

Published
2023
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27. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Fibrinolytic Therapy Trialists' (FTT) Collaborative Group

Author

APPLEBY, P, BAIGENT, C, COLLINS, R, FLATHER, M, PARISH, S, PETO, R, BELL, P, HALLS, H, MEAD, G, DIAZ, R, PAOLASSO, E, PAVIOTTI, C, ROMERO, G, CAMPBELL, T, OROURKE, M, THOMPSON, P, LESAFFRE, E, VANDEWERF, F, VERSTRAETE, M, ARMSTRONG, P, CAIRNS, J, MORAN, C, TURPIE, A, YUSUF, S, GRANDE, P, HEIKKILA, J, KALA, R, BASSAND, J, BOISSEL, J, BROCHIER, M, LEIZOROVICZ, A, BRUGGEMANN, T, KARSCH, K, KASPER, W, LAMMERTS, D, NEUHAUS, K, MEYER, J, SCHRODER, R, VONESSEN, R, SARAN, R, ARDISSINO, D, BONADUCE, D, BRUNELLI, C, CERNIGLIARO, C, FORESTI, A, FRANZOSI, M, GUIDUCCI, D, MAGGIONI, A, MAGNANI, B, MATTIOLI, G, ROSSI, P, SAONTRO, E, TOGNONI, G, VISANI, L, ZENNARO, R, KANEMOTO, N, KAWAI, C, ARNOLD, A, BAR, F, SIMOONS, M, VERHEUGT, F, VERMEER, F, WHITE, H, SEABRAGOMES, R, FIGUERAS, J, LOPEZSENDON, J, GRIP, L, HERLITZ, J, KARLSSON, J, WALLENTIN, L, MONNIER, P, ADAMS, P, BEEN, M, CHAMBERLAIN, D, DEBONO, D, DOLL, R, DUFF, D, FOX, K, SREEHARAN, N, HILLIS, W, JULIAN, D, MALCOLM, A, MURRAY, R, PATTERSON, D, POCOCK, S, REID, D, SANDERCOCK, P, SIGWART, U, SKELDING, J, SKENE, A, SLEIGHT, P, TIMMIS, A, WARLOW, C, WILCOX, R, ALLEN, A, ANDERSON, J, BRAUNWALD, E, CALIFF, R, GOLD, H, GRANETT, J, GRAINGER, C, GUERCI, A, HENNEKENS, C, HONAN, M, KENNEDY, J, KNATTERUD, G, LEE, K, LEIMBERGER, J, LENERT, L, LITTLEJOHN, J, MAYNARD, C, NICKLAS, J, OHMAN, M, OLSON, H, PASSAMANI, E, RYAN, T, SELKER, H, STUMP, D, TOPOL, E, WEAVER, W, WILLIAMS, D, and WOODLIEF, L

Abstract

Large randomised trials have demonstrated that fibrinolytic therapy can reduce mortality in patients with suspected acute myocardial infarction (AMI). The indications for, and contraindications to, this treatment in some categories of patient are disputed, examples being late presentation, elderly patients, and those in cardiogenic shock. This overview aims to help resolve some of the remaining uncertainties. From all trials of fibrinolytic therapy versus control that randomised more than 1000 patients with suspected AMI, information was sought and checked on deaths during the first 5 weeks and on major adverse events occurring during hospitalisation. The nine trials included 58,600 patients, among whom 6177 (10.5%) deaths, 564 (1.0%) strokes, and 436 (0.7%) major non-cerebral bleeds were reported. Fibrinolytic therapy was associated with an excess of deaths during days 0-1 (especially among patients presenting more than 12 h after symptom onset, and in the elderly) but this was outweighed by a much larger benefit during days 2-35. This "early hazard" should not obscure the very clear overall survival advantage that is produced by fibrinolytic therapy. Benefit was observed among patients presenting with ST elevation or bundle-branch block (BBB)--irrespective of age, sex, blood pressure, heart rate, or previous history of myocardial infarction or diabetes--and was greater the earlier treatment began. Among the 45,000 patients presenting with ST elevation or BBB the relation between benefit and delay from symptom onset indicated highly significant absolute mortality reductions of about 30 per 1000 for those presenting within 0-6 h and of about 20 per 1000 for those presenting 7-12 h from onset, and a statistically uncertain benefit of about 10 per 1000 for those presenting at 13-18 h (with more randomised evidence needed in this latter group to assess reliably the net effects of treatment). Fibrinolytic therapy was associated with about 4 extra strokes per 1000 during days 0-1: of these, 2 were associated with early death and so were already accounted for in the overall mortality reduction, 1 was moderately or severely disabling, and 1 was not. This overview indicates that fibrinolytic therapy is beneficial in a much wider range of patients than is currently given such treatment routinely.

Published
1994

28. Crystallization and preliminary X-ray analysis of Ca2+-free primary Ca2+-sensor of Na+/Ca2+exchanger

Author

Tomoo, K., primary, Mima, M., additional, Kawai, C., additional, Paku, K., additional, Ishida, T., additional, Sugiyama, S., additional, Matsumura, H., additional, Kitatani, T., additional, Yoshikawa, H.Y., additional, Maki, S., additional, Adachi, H., additional, Takano, K., additional, Murakami, S., additional, Inoue, T., additional, Mori, Y., additional, and Yamano, A., additional

Published
2008
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29. Pathogenic role of polyclonal and polymeric IgA in a murine model of mesangial proliferative glomerulonephritis with IgA deposition

Author

Muso, E, Yoshida, H, Takeuchi, E, Shimada, T, Yashiro, M, Sugiyama, T, and Kawai, C

Subjects
Molecular Weight, Disease Models, Animal, Mice, Mice, Inbred BALB C, Glomerulonephritis, Polymers, Kidney Glomerulus, Animals, Female, Research Article, Glomerular Mesangium, Immunoglobulin A
Abstract

Molecular size and charge distribution of IgA of sera and glomerular eluates were investigated in ddY mice, spontaneously developing mesangial proliferative glomerulonephritis (GN) with IgA deposition after 40 weeks of age. Serum IgA levels were increased in aged ddY mice more than 40 weeks old with a significant increase (P less than 0.01) at the age of 60 weeks, comparing with those of BALB/c mice. The isoelectric focusing (IEF) spectrotype of pooled serum IgA in 60-week-old mice ranged from 4.2 to 5.5, being similar to those in younger ddY (16 weeks old) and control BALB/c mice (12 weeks old) without enhanced expression of specific IgA peaks. However, IgA in the glomerular eluate from the 60-week-old mice showed limited anionic spectrotypes from pH 4.2 to 4.8. HPLC of IgA in pooled sera and glomerular eluates of 16-, 40- and 60-week-old ddY mice, revealed markedly increased ratios of the dimeric IgA (dIgA) and polymeric IgA (pIgA) in the total IgA with age. In the contrast to serum profiles, monomeric IgA (mIgA) was always detected as the smallest peak of the IgA fractions in glomerular eluates. Furthermore, aged mice with severe GN showed a higher percentage of dIgA and pIgA in total IgA (80%) in the sera than that of the mice with mild GN (64%). HPLC analysis under acid condition of glomerular IgA from 40-week-old ddY mice showed a similar pattern of dIgA and pIgA peaks in neutral buffer without the appearance of mIgA. These findings suggest that there is a selective mechanism for glomerular accumulation of more acid IgA among the polyclonally expanded IgA in old ddY mice, and that the polymeric form of IgA plays a pathogenic role in the development of mesangial proliferative GN in these mice.

Published
1991

35. 901-2 Randomized, Double-Blind Multicenter Trial of a Novel Modified t-PA, E6010 by i.v. Bolus Injection in Treatment of Acute Myocardial Infarction (AMI) – Comparison with Native t-PA

Author

Kawai, C., primary, Hosoda, S., additional, Yui, Y., additional, Kimata, S., additional, Kanmatsuse, K., additional, Suzuki, S., additional, Motomiya, T., additional, Yabe, Y., additional, Takatsu, F., additional, Kodama, K., additional, Minamlno, R., additional, Sato, H., additional, Nobuyoshi, M., additional, and Nakashima, M., additional

Published
1995
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