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1,198 results on '"Kawai, Kazushige"'

7. Risk of gastric adenoma and adenocarcinoma in patients with familial adenomatous polyposis in Japan: a nationwide multicenter study

Author

Sasaki, Kazuhito, Kawai, Kazushige, Nozawa, Hiroaki, Ishihara, Soichiro, Ishida, Hideyuki, Ishibashi, Keiichiro, Mori, Yoshiko, Shichijo, Satoki, Tani, Yasuhiro, Takeuchi, Yoji, Chino, Akiko, Takao, Misato, Fujiyoshi, Kenji, Matsubara, Takaaki, Miyakura, Yasuyuki, Taniguchi, Fumitaka, Yamaguchi, Tatsuro, Tanakaya, Kohji, Tomita, Naohiro, and Ajioka, Yoichi

Published
2024
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11. Preoperative chemoradiotherapy using tegafur/uracil, oral leucovorin, and irinotecan (TEGAFIRI) followed by oxaliplatin-based chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: the study protocol for a phase II trial

Author

Abe, Shinya, Kawai, Kazushige, Nozawa, Hiroaki, Sasaki, Kazuhito, Murono, Koji, Emoto, Shigenobu, Yokoyama, Yuichiro, Matsuzaki, Hiroyuki, Nagai, Yuzo, Yoshioka, Yuichiro, Shinagawa, Takahide, Sonoda, Hirofumi, Yamamoto, Yoko, Oba, Koji, and Ishihara, Soichiro

Published
2023
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23. Identification of lateral pelvic nodes without metastasis in patients with rectal cancer treated with preoperative chemoradiotherapy or chemotherapy based on magnetic resonance imaging.

Author

Hoshino, Nobuaki, Fukui, Yudai, Ueno, Kohei, Hida, Koya, Obama, Kazutaka, Sakamoto, Kazuhiro, Kobayashi, Hirotoshi, Itabashi, Michio, Ishihara, Soichiro, Kawai, Kazushige, and Ajioka, Yoichi

Subjects
MAGNETIC resonance imaging, NEOADJUVANT chemotherapy, RECTAL cancer, CANCER patients, RECTUM, THERAPEUTICS
Abstract

Background: Intensive localized therapy is promising for the treatment of rectal cancer. In Japan, chemoradiotherapy (CRT) and neoadjuvant chemotherapy (NAC) are used as preoperative treatments for this disease. Magnetic resonance imaging (MRI) is used to diagnose lateral pelvic node (LPN) metastases, but the changes in LPN findings on MRI following preoperative treatment are unclear. Furthermore, there may be patients in whom LPN dissection can be omitted after CRT/NAC. Methods: Patients who underwent total mesorectal excision with LPN dissection after CRT/NAC at 13 Japanese Society for Cancer of the Colon and Rectum member institutions between 2017 and 2019 were included. Changes in the short diameter of the LPNs after CRT/NAC and the reduction rate were examined. Results: A total of 101 LPNs were examined in 28 patients who received CRT and 228 in 47 patients who received NAC. Comparison of LPNs before and after CRT/NAC showed that most LPNs shrank after CRT but that the size reduction was variable after NAC. Although some LPNs with a short diameter of <5 mm showed residual metastasis, no metastases were observed in LPNs that were <5 mm in short diameter before and after CRT/NAC and did not shrink after treatment. Conclusion: Although the short diameter of LPNs was significantly reduced by both CRT and NAC, even LPNs with a short diameter of <5 mm could have residual metastases. However, dissection may be omitted for LPNs <5 mm in short diameter that do not shrink after preoperative CRT or NAC. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Therapeutic significance of D3 dissection for low rectal cancer: a comparison of dissections between the lateral pelvic lymph nodes and the lymph nodes along the root of the inferior mesenteric artery in a multicenter retrospective cohort study

Author

Inoue, Hiroaki, Sasaki, Kazuhito, Nozawa, Hiroaki, Kawai, Kazushige, Murono, Koji, Emoto, Shigenobu, Iida, Yuuki, Ishii, Hiroaki, Yokoyama, Yuichiro, Anzai, Hiroyuki, Sonoda, Hirofumi, Ozaki, Kousuke, Yamauchi, Shinichi, Sugihara, Kenichi, and Ishihara, Soichiro

Published
2021
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39. Risk factors and development of machine learning diagnostic models for lateral lymph node metastasis in rectal cancer: multicentre study.

Author

Kasai, Shunsuke, Shiomi, Akio, Shimizu, Hideyuki, Aoba, Monami, Kinugasa, Yusuke, Miura, Takuya, Uehara, Kay, Watanabe, Jun, Kawai, Kazushige, and Ajioka, Yoichi

Subjects
MACHINE learning, LYMPHATIC metastasis, RECEIVER operating characteristic curves, MAGNETIC resonance imaging, LYMPHADENECTOMY
Abstract

Background The diagnostic criteria for lateral lymph node metastasis in rectal cancer have not been established. This research aimed to investigate the risk factors for lateral lymph node metastasis and develop machine learning models combining these risk factors to improve the diagnostic performance of standard imaging. Method This multicentre prospective study included patients who underwent lateral lymph node dissection without preoperative treatment for rectal cancer between 2017 and 2019 in 15 Japanese institutions. First, preoperative clinicopathological factors and magnetic resonance imaging findings were evaluated using multivariable analyses for their correlation with lateral lymph node metastasis. Next, machine learning diagnostic models for lateral lymph node metastasis were developed combining these risk factors. The models were tested in a training set and in an internal validation cohort and their diagnostic performance was tested using receiver operating characteristic curve analyses. Results Of 212 rectal cancers, 122 patients were selected, including 232 lateral pelvic sides, 30 sides of which had pathological lateral lymph node metastasis. Multivariable analysis revealed that poorly differentiated/mucinous adenocarcinoma, extramural vascular invasion, tumour deposit and a short-axis diameter of lateral lymph node ≥ 6.0 mm were independent risk factors for lateral lymph node metastasis. Patients were randomly divided into a training cohort (139 sides) and a test cohort (93 sides) and machine learning models were computed on the basis of a combination of significant features (including: histological type, extramural vascular invasion, tumour deposit, short- and long-axis diameter of lateral lymph node, body mass index, serum carcinoembryonic antigen level, cT, cN, cM, irregular border and mixed signal intensity). The top three models with the highest sensitivity in the training cohort were as follows: support vector machine (sensitivity, 1.000; specificity, 0.773), light gradient boosting machine (sensitivity, 0.950; specificity, 0.918) and ensemble learning (sensitivity, 0.950; specificity, 0.917). The diagnostic performances of these models in the test cohort were as follows: support vector machine (sensitivity, 0.750; specificity, 0.667), light gradient boosting machine (sensitivity, 0.500; specificity, 0.852) and ensemble learning (sensitivity, 0.667; specificity, 0.864). Conclusion Machine learning models combining multiple risk factors can contribute to improving diagnostic performance of lateral lymph node metastasis. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Short‐ and long‐term outcomes of surgical treatment for inguinal lymph node metastasis in rectal and anal canal adenocarcinoma.

Author

Ito, Sono, Tsukamoto, Shunsuke, Kagawa, Hiroyasu, Kanemitsu, Yukihide, Hiro, Junichiro, Kawai, Kazushige, Nozawa, Hiroaki, Takii, Yasumasa, Yamaguchi, Tomohiro, Akagi, Yoshito, Suto, Takeshi, Hirano, Yasumitsu, Ozawa, Heita, Komori, Koji, Ohue, Masayuki, Toiyama, Yuji, Shinji, Seiichi, Minami, Kazuhito, Shimizu, Tomoharu, and Sakamoto, Kazuhiro

Subjects
LYMPHADENECTOMY, ANUS, LYMPHATIC metastasis, RECTAL cancer, PROGNOSIS, COLON cancer
Abstract

Aim: The significance of lymphadenectomy and its indications in patients with inguinal lymph node metastasis (ILNM) of anorectal adenocarcinoma is unclear. This study aimed to clarify the surgical outcomes and prognostic factors of inguinal lymphadenectomy for ILNM. Method: This study included patients who underwent surgical resection for ILNM of rectal or anal canal adenocarcinoma with pathologically positive metastases between 1997 and 2011 at 20 participating centres in the Study Group for Inguinal Lymph Node Metastasis from Colorectal Cancer organized by the Japanese Society for Cancer of the Colon and Rectum. Clinicopathological characteristics and short‐ and long‐term postoperative outcomes were retrospectively analysed. Results: In total, 107 patients were included. The primary tumour was in the rectum in 57 patients (53.3%) and in the anal canal in 50 (46.7%). The median number of ILNMs was 2.34. Postoperative complications of Clavien–Dindo Grade III or higher were observed in five patients. The 5‐year overall survival rate was 38.8%. Multivariate analysis identified undifferentiated histological type (P < 0.001), pathological venous invasion (P = 0.01) and pathological primary tumour depth T0–2 (P = 0.01) as independent prognostic factors for poor overall survival. Conclusion: The 5‐year overall survival after inguinal lymph node dissection was acceptable, and it warrants consideration in more patients. Further larger‐scale studies are needed in order to clarify the surgical indications. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Colorectal Cancer

Author

Kawai, Kazushige, Otani, Kensuke, Kaneko, Manabu, Murono, Koji, Sasaki, Kazuhito, Watanabe, Toshiaki, and Natsugoe, Shoji, editor

Published
2019
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48. 直腸神経内分泌腫瘍に対する内視鏡治療後の長期予後

Author

Shimizuguchi, Ryoko, primary, Koizumi, Koichi, additional, Horiguchi, Sinichiro, additional, Takao, Akinari, additional, Shibata, Satomi, additional, Natsume, Soichiro, additional, Takao, Misato, additional, Nakano, Daisuke, additional, Yamaguchi, Tatsuro, additional, Kawai, Kazushige, additional, and Iizuka, Toshiro, additional

Published
2024
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