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8. Abstracts

Author

MATSUZAKI, Toshiyuki, primary, SUZUKI, Takeshi, additional, TAKATA, Kuniaki, additional, HASHIGUCHI, Shin, additional, HIRATA, Masazumi, additional, MURATA, Hiroaki, additional, TAKESHITA, Hideyuki, additional, KUSUZAKI, Katsuyuki, additional, KONISHI, Eiichi, additional, HIRASAWA, Yasusuke, additional, ASHIHARA, Tsukasa, additional, Suginoshita, T., additional, Kusuzaki, K., additional, Hashiguchi, S., additional, Hirata, M., additional, Fukuroku, J., additional, Urata, Y., additional, Hirasawa, Y., additional, Ashihara, T., additional, KAWAI, Kanji, additional, UEDA, Kazushige, additional, OCHIAI, Toshiya, additional, OGINO, Atsuhiro, additional, ITOI, Hirosumi, additional, YAMAGISHI, Hisakazu, additional, URATA, Yoji, additional, OKA, Takahiro, additional, YAMAASHI, Toshiaki, additional, AKITA, Masahiko, additional, TANOOKA, Ken, additional, SETSU, Kojun, additional, Maezawa, Yasuhisa, additional, Baba, Hisatoshi, additional, Furusawa, Nobuaki, additional, Uchida, Kenzou, additional, Imura, Shinichi, additional, TAMADA, Yoshitaka, additional, HAYASHI, Seiji, additional, IIJIMA, Norio, additional, IKE, Hiromi, additional, ISHIHARA, Akihiko, additional, TANAKA, Masaki, additional, SUWA, Fumihiko, additional, IBATA, Yasuhiko, additional, Kimura, Masaru, additional, SUGA, Hiroyasu, additional, MIYOSI, Norio, additional, NAKAGAWA, Takao, additional, FUKUDA, Masaru, additional, Zinchuk, Vadim S., additional, Okada, Teruhiko, additional, Kobayashi, Toshihiro, additional, Saz, Eva Garcia del, additional, Seguchi, Harumichi, additional, Zhang, Youyun, additional, Dai, Jibin, additional, Zhou, Xinhua, additional, Dong, Fong, additional, HEMMI, Akihiro, additional, KOMIYAMA, Akira, additional, OHNO, Shinichi, additional, KATOH, Ryohei, additional, Takeshita, Hideyuki, additional, Kusuzaki, Katsuyuki, additional, Tsuji, Yoshiro, additional, Hirata, Masazumi, additional, Hashiguchi, Shin, additional, Hirasawa, Yasusuke, additional, Ashihara, Tsukasa, additional, MORIKAWA, Shigeru, additional, TORII, Ikuko, additional, NAGASAKI, Makoto, additional, MISHIMA, Satoko, additional, Mizoguchi, Akira, additional, Ide, Chizuka, additional, NAITO, Ichiro, additional, INOUE, Satoko, additional, SENO, Satimaru, additional, WATANABE, Jun, additional, KONDO, Kazumasa, additional, Mino, Kazuto, additional, KANAMURA, Shinsuke, additional, CHIDA, Kohsuke, additional, GOTO, Tetusya, additional, TANAKA, Teruo, additional, TAKAMI, Shigeru, additional, ODA, Tatsuroh, additional, NISHIYAMA, Fumiaki, additional, Wakayama, Tomohiko, additional, Iseki, Shoichi, additional, KHALED, AHMED, additional, NORIKI, S., additional, MAEGAWA, H., additional, FUKUDA, M., additional, Jiang, Mingsen, additional, Yu, Zujiang, additional, Yang, Mingyi, additional, Dong, Huifen, additional, UENO, Masaki, additional, FUTAESAKU, Yutaka, additional, KOZUKA, Yoshimichi, additional, YANO, Misai, additional, ONO, Michiko, additional, SUMI, Yawara, additional, Itoh, Masanori T., additional, YOSHIDA, Minoru, additional, Ito, Atsuko, additional, Hayashi, Michiko, additional, Hoshida, Minako, additional, Ito, Kinji, additional, NAKAZATO, Kyoumi, additional, SUZUKI, Keiji, additional, NAKAJIMA, Katuyuki, additional, SAGA, Tsuyoshi, additional, YOSHIZUKA, Mitsuaki, additional, Nemoto, Norimichi, additional, Lu, Wei, additional, Nakamura, Hitomi, additional, Hayakawa, Satoshi, additional, Chishima, Fuminao, additional, WATANABA, Akio, additional, KAWAOI, Akira, additional, KRIA, Lidia, additional, OHIRA, Akihiro, additional, AMEMIYA, Tsugio, additional, KARAYA, Kazuhiro, additional, KONDO, Takashi, additional, UMEMURA, Shinobu, additional, YASUDA, Masanori, additional, ITOH, Johbu, additional, TAKEKOSHI, Susumu, additional, OSAMURA, Yoshiyuki, additional, WATANABE, Keiichi, additional, SASAKI, Yukihiro, additional, AHMED, Helen, additional, TAKEUCHI, Takumi, additional, UEKI, Tetsuo, additional, KAJIWARA, Takahiro, additional, MORIYAMA, Nobuo, additional, KAWABE, Kazuki, additional, YOKOI, Hiromichi, additional, YAMAMA, Yoshihiro, additional, TSURUO, Yoshihiro, additional, ISHIMURA, Kazunori, additional, Kato, Yoichiro, additional, Yamamoto, Tomoko, additional, Kobayashi, Makio, additional, KOMIYAMA, Shin-ichi, additional, AOKI, Daisuke, additional, TOMINAGA, Eiichiro, additional, SUSUMU, Nobuyuki, additional, UDAGAWA, Yasuhiro, additional, NOZAWA, Shiro, additional, MURATA, Hideaki, additional, URATA, Youzi, additional, Ito, Toshihisa, additional, HORITA, Kohjiro, additional, IMAMURA, Yoshiaki, additional, NORIKI, Sakon, additional, NAKAGAWARA, Gizo, additional, Mo, Yiqun, additional, Zhang, Qunwei, additional, Yamaguchi, Akio, additional, Horita, Kohjiro, additional, Zheng, Shu, additional, Leng, Chong-Guang, additional, Ueda, Hideho, additional, Fujii, Yasuhisa, additional, Terada, Nobuo, additional, Baba, Takeshi, additional, Yamazaki, S., additional, Kameyama, S., additional, Fukasawa, R., additional, Moriyama, N., additional, Kawabe, K., additional, KOBAYASHI, Yasuhiro, additional, KAWAKAMI, Hayato, additional, YOSHINO, Yoshikazu, additional, HIRANO, Hiroshi, additional, AKIMOTO, Yoshihiro, additional, KREPPEL, Lisa K., additional, HART, Gerald W., additional, KAWASHIMA, Kenji, additional, NAKAZATO, Kyomi, additional, HIRAISHI, Katsuya, additional, UEHARA, Katsuaki, additional, SHIMADA, Junichi, additional, FUSHIKI, Shinji, additional, Susumu, Nobuyuki, additional, ARAI, Ryohachi, additional, SAKAI, Kazuyoshi, additional, NAGATSU, Ikuko, additional, Shin, Bo-Chul, additional, ASAKAWA, Yoshihiro, additional, KOMURO, Masato, additional, Zhou, Lanxian, additional, Yuan, Hua, additional, Hu, Jialuo, additional, Huang, Wenduo, additional, Wang, Xiaoyun, additional, MIYAMOTO, Yohei, additional, SHIMBO, Mari, additional, TAHARA, Shigeyuki, additional, SUGIYAMA, Makoto, additional, TAKUMI, Ichiro, additional, SANNO, Naoko, additional, TERAMOTO, Akira, additional, MATSUDA, Minoru, additional, FUKUSHIMA, Hisaki, additional, TANAKA, Ryota, additional, SANTO, Ikuya, additional, HANAOKA, Tateo, additional, GOYA, Tomoyuki, additional, KUDO, Akihiko, additional, and Kudo, Akihiko, additional

Published
1998
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9. The Relationship between Numerical Aberrations of Chromosome 17 and Nuclear DNA Content in Colorectal Carcinoma Detected by Fluorescent In Situ Hybridization (FISH) and Cytofluorometry Using Auto-scanning Stage.

Author

Kawai, Kanji, primary, Hamada, Shinshichi, additional, Yamagishi, Hisakazu, additional, Itoi, Hirosumi, additional, Ochiai, Toshiya, additional, Ogino, Atsuhiro, additional, Konishi, Eiichi, additional, Urata, Yoji, additional, Oka, Takahiro, additional, and Ashihara, Tsukasa, additional

Published
1997
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10. Carcinoid Tumor of the Cecum with Expression of p53 Gene Product.

Author

Umeda, Tomoko, primary, Inaba, Saishiro, additional, Kondo, Yuji, additional, Tsuchiya, Kuniyuki, additional, Kawai, Kanji, additional, Ogino, Atsuhiro, additional, Katano, Tomoko, additional, Ueda, Yasuaki, additional, Kushima, Ryouji, additional, Hattori, Takanori, additional, and Kodama, Masashi, additional

Published
1995
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12. CLINICAL STUDY OF EARLY GASTRIC CANCER WITH LYMPH NODE METASTASIS

Author

KOBAYASHI, Masao, primary, YAMAGISHI, Hisakazu, additional, SONOYAMA, Teruhisa, additional, OMORI, Kouji, additional, UEKI, Takanori, additional, KOBAYASHI, Yoshinori, additional, TANIOKA, Yasuhiko, additional, TANIMUKAI, Shigeatsu, additional, KAWAI, Kanji, additional, MORITA, Shuuji, additional, FUJIWARA, Ikuya, additional, and OKA, Takahiro, additional

Published
1993
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17. Estimation of the Amount of Amorphous Materials for Characterizing Andosols

Author

Kawai, Kanji

Abstract

An estimation method of amorphous inorganic materials in soils for characterizing andosols and tentative criteria for classification of andosols was proposed. Organic matter‐free fine earth is treated with 0.2Noxalic acid solution at 40°C for 6 hours under about 10,000 lux by a fluorescent lamp. The amounts of extracted silica, aluminum, and iron are highly correlated with values determined by the alternate dissolution method using hydrochloric acid and sodium hydroxide solutions. Andepts have more than 50% of amorphous inorganic materials in the clay fraction as determined by the pipette method after treated by ultrasonic vibration. The soils, derived from volcanic ash and/or volcanic ash influenced or redeposited, containing < 50% of amorphous inorganic materials in the clay fraction and < 20% on an ovendry basis, are included in Andeptic subgroups.

Published
1977
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21. [A Case of Locally Advanced Adenosquamous Carcinoma of the Pancreas Accompanied by Hepatic Metastasis Treated by Resection of the Primary Lesion as Palliative Care].

Author

Kawai K, Okamura H, Fujiwara A, Yoshii K, and Sagara Y

Subjects
Humans, Male, Middle Aged, Pancreas, Carcinoma, Adenosquamous secondary, Carcinoma, Adenosquamous therapy, Liver Neoplasms secondary, Liver Neoplasms surgery, Palliative Care, Pancreatic Neoplasms
Abstract

A 61-year-old man presented to our hospital with appetite loss. Gastroscopy revealed a tumor on the upper body of the stomach. Persistent bleeding was observed from the tumor; therefore, the patient was immediately hospitalized. An abdominal CT scan revealed that the tumor arose from the pancreas and invaded the spleen, stomach, and transverse colon. Furthermore, a hepatic tumor was observed at the posterior segment and blood tests showed increased CA19-9 level. Therefore, the tumor was diagnosed as pancreatic cancer with invasion of the adjacent organs and hepatic metastasis. Although the tumor was classified as unresectable for the distant metastasis, resection of the primary lesion was performed to control the bleeding and obstruction at the invasion sites. The pathological diagnosis of the tumor was adenosquamous carcinoma. The patient subsequently underwent chemotherapy and was discharged from the hospital on postoperative day 34. The patient was able to spend time at home and was treated at an outpatient clinic until postoperative day 110, when his generalcondition deteriorated. In this case, resection of the primary lesion was ineffectual for a life prognosis but was beneficial for palliative care.

Published
2019

22. [A Case of Solitary Lymph Node Recurrence Accompanied by Metachronous Multiple Lesion after Definitive Chemoradiotherapy for Esophageal Cancer].

Author

Kawai K, Fujiwara A, Okamura H, Watanabe K, and Sagara Y

Subjects
Carcinoma, Squamous Cell secondary, Esophageal Neoplasms pathology, Esophagectomy, Humans, Laparoscopy, Lymph Node Excision, Lymphatic Metastasis, Male, Middle Aged, Carcinoma, Squamous Cell therapy, Chemoradiotherapy, Esophageal Neoplasms therapy
Abstract

A 53-year-old man was diagnosed with squamous cell carcinoma of the upper thoracic esophagus in cT3N1M0, cStage III (UICC 6th edition). The patient underwent definitive chemoradiotherapy(dCRT)and achieved a complete response in May 2008. Five and a half years after dCRT, swelling of the cardiac lymph node was detected on CT. Frequent check-up was performed in the subsequent 1 year and 10 months, during which the recurrent lesion was revealed as solitarybyPET -CT. No signs of recurrence were detected at the site of the primarylesion byendoscopic examination; however, another superficial cancer was found at a different site. Endoscopic submucosal dissection was performed for the esophageal lesion, and laparoscopic lymphadenectomy was applied to the cardiac lymph node. We herein report a case of a male patient who underwent minimal invasive locoregional treatments for both metachronous multiple lesions and solitaryly mph node recurrence after dCRT.

Published
2017

23. Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from nonmetastatic breast tumors as revealed by labeling with green fluorescent protein.

Author

Goodison S, Kawai K, Hihara J, Jiang P, Yang M, Urquidi V, Hoffman RM, and Tarin D

Subjects
Animals, Breast Neoplasms metabolism, Cell Division, Cell Line, Cell Line, Tumor, Cell Survival, Female, Green Fluorescent Proteins, Humans, Luminescent Proteins metabolism, Mice, Mice, Nude, Neoplasm Metastasis, Phenotype, Retroviridae genetics, Time Factors, Breast Neoplasms pathology, Luminescent Proteins pharmacology, Microscopy, Fluorescence methods
Abstract

This study used an isogenic pair of metastatic (M4A4) and nonmetastatic (NM2C5), green fluorescent protein-labeled human breast cancer cell lines derived from the same patient and inoculated into the mammary glands of nude mice to investigate the dissemination patterns and fate of cells that escaped spontaneously from the resulting tumors. After tumors appeared, fluorescing single tumor cells were regularly seen in the lungs, even in animals inoculated with NM2C5, which fails to form secondary tumors in other organs. The sensitivity of the technique confirmed the continuing presence of scattered NM2C5 cells after primary tumor resection, although they formed no metastases by 6 months. These self-disseminated human tumor cells were retrievable from the tissues and were still viable and malignant, manifested by indefinite proliferation in vitro and green fluorescence and local tumorigenicity in vivo. Therefore, these scattered tumor cells were still immortal but rendered indefinitely quiescent by the microenvironmental conditions in the lung tissue. This is the first unequivocal demonstration of spontaneous distant dissemination of human cancer cells by undisturbed nonmetastatic tumors and comprises a valuable system for the analysis of tumor dormancy. In contrast, although many of the cells disseminating from M4A4 tumors grew into fluorescing metastases in the lungs, others remained solitary and quiescent. Therefore, even in a clonally derived cell population with metastatic properties, many cells do not, or cannot, mobilize the organ-specific growth properties needed to generate metastases. This experimental approach, by using self-disseminating, green fluorescent protein-labeled, sister cell lines of opposing metastatic phenotypes, opens new avenues for investigating topics of clinical relevance, including tumor cell dormancy, anatomical distribution of metastases, and host factors influencing the metastatic process.

Published
2003

24. Contrasting expression of thrombospondin-1 and osteopontin correlates with absence or presence of metastatic phenotype in an isogenic model of spontaneous human breast cancer metastasis.

Author

Urquidi V, Sloan D, Kawai K, Agarwal D, Woodman AC, Tarin D, and Goodison S

Subjects
Animals, Biomarkers, Tumor, Breast Neoplasms metabolism, Breast Neoplasms pathology, Cell Division, Cell Survival, DNA Primers chemistry, Disease Progression, Female, Humans, Hyaluronan Receptors metabolism, Immunoenzyme Techniques, Karyotyping, Lung Neoplasms metabolism, Lung Neoplasms secondary, Mice, Mice, Nude, Neoplasm Proteins metabolism, Neoplasm Transplantation, Osteopontin, Phenotype, Prognosis, Reverse Transcriptase Polymerase Chain Reaction, Sialoglycoproteins metabolism, Thrombospondin 1 metabolism, Breast Neoplasms genetics, Gene Expression Regulation, Neoplastic genetics, Lung Neoplasms genetics, Neoplasm Proteins genetics, Sialoglycoproteins genetics, Thrombospondin 1 genetics
Abstract

Knowledge of the molecular mechanisms involved in metastatic spread is needed to facilitate advances in prognostic evaluation for individual patients and in the design of therapeutic interventions to inhibit the process. In an effort to establish a methodological framework for analysis of molecules and mechanisms involved in this complex multistep process, we have developed a well defined experimental system, in which the role of candidate genes can be screened and tested. By serial dilution cloning of the MDA-MB-435 breast tumor cell line and screening by orthotopic implantation into the mammary fat pad of athymic mice, we have derived a pair of breast tumor cell lines (M-4A4 and NM-2C5) that originate from the same breast tumor but have diametrically opposite metastatic capabilities. In 74% of inoculated athymic mice, clone M-4A4 metastasized consistently to the lungs, mimicking a major dissemination route of human breast cancer. Conversely, although equally tumorigenic, clone NM-2C5 did not metastasize to any distal site. We have confirmed that the cell lines originate from a single genetic source by spectral karyotyping and evaluated the expression of a number of proteins previously implicated in cellular transformation and metastasis. The ability of M-4A4 to metastasize was not associated with increased angiogenesis, as measured by immunohistochemical microvessel density analysis. However, RNA and protein analyses revealed that two secreted proteins were differentially expressed: osteopontin expression was increased approximately 30-fold in clone M-4A4 and thrombospondin-1 expression was increased approximately 15-fold in clone NM-2C5. These cell lines constitute a stable and accessible model for the identification of genes involved in the multistep process of breast tumor metastasis. Manipulation of candidate genes in these cells will permit evaluation of their functional significance in the geometric progression of breast cancer.

Published
2002

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