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Background of Study: 1-methyl-4 phenyl-pyridinium (MPTP), a neurotoxin inhibits mitochondrial membrane complex mechanism, causes Parkinson’s diseases. MPTP has the ability to generate more debris, neuronal death. The main aim of the study to determine the neuroprotective effects of gingerols against MPTP (neurotoxin) result s cell death (programmed) SKN-SH cells. Gingerol is an active compound of ginger, which possesses a wide range of pharmacological properties, including potent antioxidant anti-inflammatory and anti-apoptotic. Materials and Methods: Analyzing the following parameters such as MTT assay for cell death and cell viability, mitochondrial membrane potential (ATP), increased/decreased level of reactive oxygen species (ROS) generation, TBRAS levels, and biochemical activities were estimated. The gingerol was treated with (neuroblastoma) cell line to know the loss of mitochondrial membrane potential, increased ROS generations, and other cellular reaction. Results: Data revealed that gingerol has the neuroprotective effect against MPTP due to its antioxidant properties, level of mitochondria function was maintained, anti-inflammatory, and antiapoptotic properties in the cell line also studied. [ABSTRACT FROM AUTHOR]

Background of the Study: Parkinson's disease (PD) is one of the neurodegenerative disorders due to the loss of dopaminergic neurons in the substantia nigra and reduction in the striatum dopamine. Objective: The purpose of the study deals with neuroprotective effects of gingerol, against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mice model of PD. Materials and Methods: A combination of behavioral task using graphical representation and biochemical parameters was tested using standard molecular tools method. Results: Gingerol activity shows the increase the level of dopamine and its metabolites enhanced the behavior activity of the animal models. Conclusion: This present is need to understand the neuroprotective and antioxidant properties while devolping the new experimental modalities for parkinsiom. [ABSTRACT FROM AUTHOR]

Background. The hepatic injury due to oxidative stress was ameliorated through administration of an aqueous extract of Eclipta alba leaves and suggested that wedelolactone and demethylwedelolactone were the possible components of Eclipta alba behind the protective effect on liver as well as against liver disorders. Objective. To study the hepato-protective effects of Eclipta alba on high fatty diet treated experimental models. Materials and Methods. A total of 30 adult albino rats of Wistar strain weighing 165-215 grams, from the animal house of the Basaveshwara Medical College, Hospital and Research Centre, Chitradurga, were used for the present study: group 1 included animals fed with normal diet (control); group 2, animals treated with hyperlipidemic diet for eight weeks; group 3, animals treated with hyperlipidemic diet for eight weeks, followed by one week post treatment of Eclipta alba with normal diet; group 4, animals treated with hyperlipidemic diet for eight weeks, followed by two weeks post-treatment of Eclipta alba with normal diet; and group 5, animals treated with hyperlipidemic diet for eight weeks, followed by three weeks post-treatment of Eclipta alba with normal diet. Results. In animals with high fat diet (30%), we observed the deposition of fat in the form of fat lobules in and around the hepatocytes, mononuclear infiltration in the liver parenchyma, dilation of blood vessels, necrotic foci and damaged hepatocytes. Conclusion. The components of Eclipta alba like wedelolactone, demethylwedelolactone and saponins reduced fat deposition, mononuclear infiltration, and necrotic foci, and stimulated hepatocyte regeneration in the liver. [ABSTRACT FROM AUTHOR]

The present study deals with the gas chromatography-mass spectrometry (GC-MS) analysis of one ayurvedic formulation Drakshadi Lehyam, which is prescribed for liver-related diseases. Materials and Methods: The medicine was procured from the standard ayurvedic vendor and subjected to GC-MS analysis following standard protocol. Results: It was observed that some important medicinal molecules such as cyclohexanamine, N-3-butenyl-N-methyl-, cyclopentane, 1-acetyl-1, 2-epoxy-, 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl-, benzoic acid, heptane diamide, N,N’-di-benzoyloxy-, p-hydrazinobenzamidoxime, hexanediamide, N,N’-di-benzoyloxy-, Benzoic acid, ethyl ester, coumarin, 2-Amino-4-tert-butylphenol, cyclopentan-1-al, 4-isopropylidene-2-methyl-, 1-Adamantanamine, N,N-dimethyl-, Tetradecanoic acid, 1,1-Diphenyl-4-phenylthiobut-3-en-1-ol, 1H-2-Indenone,2,4,5,6,7,7a-hexahydro-3-(1-methylethyl)-7a-methyl, n-Hexadecanoic acid, 1-Heptatriacotanol, cis-13-Octadecenoic acid, Octadecanoic acid, benzoic acid, 3,4,5-trimethoxy-2-nitro-, methyl ester, 3-(3-Hydroxy-4-methoxyphenyl)-l-alanine, and hexadecanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester were present, which are indicative of the medicinal role of Drakshadi Lehyam. Conclusions: The medicinal roles of the majority of the molecules do represent the medicinal properties of Drakshadi Lehyam as a potent liver tonic. [ABSTRACT FROM AUTHOR]

Objective: The present study deals with the Gas chromatography-mass spectrometry (GC-MS) analysis of one ayurvedic Rasayana formulation, “Brahma Rasayanam,” which is a health rejuvenating tonic prescribed in Ayurveda. Materials and Methods: Brahma Rasayanam was procured from ayurvedic vendor at Chennai and subjected to GC-MS procedure by following standard protocol. Results: The GC-MS profile indicated the presence of some very important biomolecules such as 5-Hydroxymethylfurfural, 2H-Pyran-2-one, tetrahydro-6-nonyl-, n-hexadecanoic acid, tetradecanoic acid, and n-decanoic acid. Conclusion: The medicinal roles of the molecules represent that of Brahma Rasayanam itself, further work to standardize the medicine is warranted. [ABSTRACT FROM AUTHOR]

Introduction: This study aims to know the types of biomolecules present in Eladi Kera Thailam and to correlate their possible medicinal roles supporting Eladi Kera Thailam’s role as medicine. Methods: Eladi Kera Thailam was bought from a standard Ayurvedic vendor at Chennai and subjected to gas chromatography/mass spectrometry (GC/MS) analysis by standard procedures. The medicinal roles of the biomolecules indicated in the GC/MS profile were screened for their various medicinal roles using Dr. Duke’s phytochemical and ethnobotanical data and other data. Results: The presence of some important biomolecules such as dodecanoic acid, 2,3-dihydroxypropyl ester, dodecanoic acid, 2-hydroxy-1-(hydroxymethyl) ethyl ester, octadecanoic acid, 2,3-dihydroxypropyl ester, and dodecanoic acid, 1,2,3-propanetriyl ester does have medicinal roles which contribute to Eladi Kera Thailam as a medicine for skin ailments. Conclusions: The GC/MS profile indicated the presence of some important biomolecules which have medicinal properties contributing to the role of Eladi Kera Thailam as a skin cure medicine. The study is a step in the direction of understanding the molecular mechanism of contemporary and alternative medicines. [ABSTRACT FROM AUTHOR]