16 results on '"Kavelj, Ivana"'
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2. Stable Gastric Pentadecapeptide BPC 157 Therapy: Effect on Reperfusion Following Maintained Intra-Abdominal Hypertension (Grade III and IV) in Rats
- Author
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Tepes, Marijan, primary, Krezic, Ivan, additional, Vranes, Hrvoje, additional, Smoday, Ivan Maria, additional, Kalogjera, Luka, additional, Zizek, Helena, additional, Vukovic, Vlasta, additional, Oroz, Katarina, additional, Kovac, Katarina Kasnik, additional, Madzar, Zrinko, additional, Rakic, Mislav, additional, Miskic, Blazenka, additional, Sikiric, Suncana, additional, Barisic, Ivan, additional, Strbe, Sanja, additional, Antunovic, Marko, additional, Novosel, Luka, additional, Kavelj, Ivana, additional, Vlainic, Josipa, additional, Dobric, Ivan, additional, Staresinic, Mario, additional, Skrtic, Anita, additional, Seiwerth, Sven, additional, Blagaic, Alenka Boban, additional, and Sikiric, Predrag, additional
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- 2023
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3. Pentadecapeptide BPC 157 as Therapy for Inferior Caval Vein Embolization: Recovery of Sodium Laurate-Post-Embolization Syndrome in Rats
- Author
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Smoday, Ivan Maria, primary, Krezic, Ivan, additional, Kalogjera, Luka, additional, Vukovic, Vlasta, additional, Zizek, Helena, additional, Skoro, Marija, additional, Kovac, Katarina Kasnik, additional, Vranes, Hrvoje, additional, Barisic, Ivan, additional, Sikiric, Suncana, additional, Strbe, Sanja, additional, Tepes, Marijan, additional, Oroz, Katarina, additional, Zubcic, Slavica, additional, Stupnisek, Mirjana, additional, Beketic Oreskovic, Lidija, additional, Kavelj, Ivana, additional, Novosel, Luka, additional, Prenc, Matea, additional, Barsic Ostojic, Sanja, additional, Dobric, Ivan, additional, Sever, Marko, additional, Blagaic, Alenka Boban, additional, Skrtic, Anita, additional, Staresinic, Mario, additional, Sjekavica, Ivica, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional
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- 2023
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4. Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions
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Sikiric, Predrag, primary, Kokot, Antonio, additional, Kralj, Tamara, additional, Zlatar, Mirna, additional, Masnec, Sanja, additional, Lazic, Ratimir, additional, Loncaric, Kristina, additional, Oroz, Katarina, additional, Sablic, Marko, additional, Boljesic, Marta, additional, Antunovic, Marko, additional, Sikiric, Suncana, additional, Strbe, Sanja, additional, Stambolija, Vasilije, additional, Beketic Oreskovic, Lidija, additional, Kavelj, Ivana, additional, Novosel, Luka, additional, Zubcic, Slavica, additional, Krezic, Ivan, additional, Skrtic, Anita, additional, Jurjevic, Ivana, additional, Boban Blagaic, Alenka, additional, Seiwerth, Sven, additional, and Staresinic, Mario, additional
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- 2023
- Full Text
- View/download PDF
5. Antiarrhythmic Sotalol, Occlusion/Occlusion-like Syndrome in Rats, and Stable Gastric Pentadecapeptide BPC 157 Therapy
- Author
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Premuzic Mestrovic, Ivica, primary, Smoday, Ivan Maria, additional, Kalogjera, Luka, additional, Krezic, Ivan, additional, Zizek, Helena, additional, Vranes, Hrvoje, additional, Vukovic, Vlasta, additional, Oroz, Katarina, additional, Skorak, Ivan, additional, Brizic, Ivan, additional, Hriberski, Klaudija, additional, Novosel, Luka, additional, Kavelj, Ivana, additional, Barisic, Ivan, additional, Beketic Oreskovic, Lidija, additional, Zubcic, Slavica, additional, Strbe, Sanja, additional, Mestrovic, Tomislav, additional, Pavic, Predrag, additional, Staresinic, Mario, additional, Skrtic, Anita, additional, Boban Blagaic, Alenka, additional, Seiwerth, Sven, additional, and Sikiric, Predrag, additional
- Published
- 2023
- Full Text
- View/download PDF
6. Current Role of Magnetic Resonance Imaging in the Screening, Diagnosis, and Treatment of Prostate Cancer
- Author
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Nikles, Sven, Pezelj, Ivan, Tomić, Miroslav, Knežević, Matej, Vrhovec, Borna, Dumbović, Leo, Pirša, Matea, Kavelj, Ivana, Tomašković, Igor, Nikles, Sven, Pezelj, Ivan, Tomić, Miroslav, Knežević, Matej, Vrhovec, Borna, Dumbović, Leo, Pirša, Matea, Kavelj, Ivana, and Tomašković, Igor
- Abstract
Prostate cancer is the most common cancer in men. Diagnosis of prostate cancer poses a significant challenge, due to several different key parameters that need to be evaluated, such as age, history of prostate specific antigen (PSA), clinical examination and more recently magnetic resonance imaging (MRI). The current diagnostic pathway for prostate cancer has resulted in overdiagnosis and overtreatment as well as underdiagnosis and missed diagnoses in many men. Multiparametric MRI (mp-MRI) of the prostate has been identified as a test that could alleviate these diagnostic errors. Before prostate cancer treatment pathological confirmation is mandatory. Prostate biopsy is an invasive procedure with rare but not negligible potential complications. There are several methods of prostate biopsy of which most common are systemic or planar prostate biopsy and cognitive or targeted MRI-guided prostate biopsy. Multiparametric MRI has demonstrated better accuracy and reproducibility in detecting, locating and evaluating prostate cancer and also sparing some men unnecessary biopsies. Recent studies have shown a mpMRI benefit for better procedure planning regarding prostate cancer location, extent of disease and length of the urethra. There are still some challenges ahead, such as ensuring high-quality execution and reporting of mpMRI and ensuring that this diagnostic pathway is cost-effective. According to the latest urological clinical guidelines mpMRI became fundamental tool in management of prostate cancer. The aim of this study is to give a brief insight in use of mpMRI in prostate cancer diagnosis and treatment., Rak prostate najčešći je karcinom u muškaraca. Dijagnoza raka prostate predstavlja značajan izazov zbog nekoliko različitih ključnih parametara koje je potrebno procijeniti, kao što su dob, povijest prostata specifičnog antigena (PSA), klinički pregled i u novije vrijeme multiparametrijski MRI (mp-MRI). Trenutna dijagnostika raka prostate rezultirala je prekomjernom dijagnostikom i liječenjem, kao i poddijagnozom i propuštenom dijagnozom kod mnogih muškaraca. Multiparametrijski MRI prostate identificiran je kao test koji bi mogao ublažiti ove pogreške. Prije liječenja raka prostate obavezna je patološka potvrda. Biopsija prostate je invazivan postupak s rijetkim, ali ne i zanemarivim potencijalnim komplikacijama. Postoji nekoliko metoda biopsije prostate od kojih su najčešće sistemska ili planarna biopsija prostate i kognitivna ili ciljana biopsija prostate vođena MRI-om. Mp-MRI pokazao je bolju točnost i reproducibilnost u otkrivanju, lociranju i procjeni raka prostate, a također je poštedio neke muškarace nepotrebne biopsije. Nedavne studije pokazale su korist mpMRI-e za bolje planiranje zahvata s podacima o lokaciji raka prostate, opsegu bolesti i duljini uretre. Pred nama su još neki izazovi, poput osiguravanja visokokvalitetne izvedbe i izvješćivanja o mpMRI-u te osiguravanja da je ovaj dijagnostički put isplativ. Prema najnovijim urološkim kliničkim smjernicama mpMRI je postao temeljni alat u liječenju raka prostate. Cilj ove studije je dati kratak uvid u upotrebu mpMRI-e u dijagnostici i liječenju raka prostate.
- Published
- 2022
7. Trenutno mjesto magnetske rezonance u probiru, dijagnostici i liječenju raka prostate
- Author
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Nikles, Sven, Pezelj, Ivan, Tomić, Miroslav, Knežević, Matej, Vrhovec, Borna, Dumbović, Leo, Pirša, Matea, Kavelj, Ivana, and Tomašković, Igor
- Subjects
Rak prostate ,mpMRI ,biopsija prostate ,dijagnostika i liječenje raka prostate ,Prostate Cancer ,MpMRI ,Prostate Biopsy ,Prostate Cancer Diagnosis and Treatment - Abstract
Prostate cancer is the most common cancer in men. Diagnosis of prostate cancer poses a significant challenge, due to several different key parameters that need to be evaluated, such as age, history of prostate specific antigen (PSA), clinical examination and more recently magnetic resonance imaging (MRI). The current diagnostic pathway for prostate cancer has resulted in overdiagnosis and overtreatment as well as underdiagnosis and missed diagnoses in many men. Multiparametric MRI (mp-MRI) of the prostate has been identified as a test that could alleviate these diagnostic errors. Before prostate cancer treatment pathological confirmation is mandatory. Prostate biopsy is an invasive procedure with rare but not negligible potential complications. There are several methods of prostate biopsy of which most common are systemic or planar prostate biopsy and cognitive or targeted MRI-guided prostate biopsy. Multiparametric MRI has demonstrated better accuracy and reproducibility in detecting, locating and evaluating prostate cancer and also sparing some men unnecessary biopsies. Recent studies have shown a mpMRI benefit for better procedure planning regarding prostate cancer location, extent of disease and length of the urethra. There are still some challenges ahead, such as ensuring high-quality execution and reporting of mpMRI and ensuring that this diagnostic pathway is cost-effective. According to the latest urological clinical guidelines mpMRI became fundamental tool in management of prostate cancer. The aim of this study is to give a brief insight in use of mpMRI in prostate cancer diagnosis and treatment., Rak prostate najčešći je karcinom u muškaraca. Dijagnoza raka prostate predstavlja značajan izazov zbog nekoliko različitih ključnih parametara koje je potrebno procijeniti, kao što su dob, povijest prostata specifičnog antigena (PSA), klinički pregled i u novije vrijeme multiparametrijski MRI (mp-MRI). Trenutna dijagnostika raka prostate rezultirala je prekomjernom dijagnostikom i liječenjem, kao i poddijagnozom i propuštenom dijagnozom kod mnogih muškaraca. Multiparametrijski MRI prostate identificiran je kao test koji bi mogao ublažiti ove pogreške. Prije liječenja raka prostate obavezna je patološka potvrda. Biopsija prostate je invazivan postupak s rijetkim, ali ne i zanemarivim potencijalnim komplikacijama. Postoji nekoliko metoda biopsije prostate od kojih su najčešće sistemska ili planarna biopsija prostate i kognitivna ili ciljana biopsija prostate vođena MRI-om. Mp-MRI pokazao je bolju točnost i reproducibilnost u otkrivanju, lociranju i procjeni raka prostate, a također je poštedio neke muškarace nepotrebne biopsije. Nedavne studije pokazale su korist mpMRI-e za bolje planiranje zahvata s podacima o lokaciji raka prostate, opsegu bolesti i duljini uretre. Pred nama su još neki izazovi, poput osiguravanja visokokvalitetne izvedbe i izvješćivanja o mpMRI-u te osiguravanja da je ovaj dijagnostički put isplativ. Prema najnovijim urološkim kliničkim smjernicama mpMRI je postao temeljni alat u liječenju raka prostate. Cilj ove studije je dati kratak uvid u upotrebu mpMRI-e u dijagnostici i liječenju raka prostate.
- Published
- 2022
8. MRI maze solving of perianal fistulas for beginners
- Author
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Kavelj, Ivana
- Subjects
Inflammation ,Complications ,Fistula ,Colon ,GI Tract ,MR ,Abscess ,Gastrointestinal tract ,Not applicable ,Abdomen ,Performed at one institution ,Diagnostic procedure ,Structured reporting ,MR-Diffusion/Perfusion - Abstract
Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References, Learning objectives: 1. to repeat anal canal anatomy in details, 2. to get familiar with perianal fistula classifications, complexity, complications and its implication for therapy through pictorial MR review, 3. to accentuate mandatory findings that surgeon expect us...
- Published
- 2020
- Full Text
- View/download PDF
9. COVID–19 u Bosni i Hercegovini
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Kavelj, Ivana
- Subjects
COVID-19 ,BIH ,prevalencija - Abstract
Cilj istraživanja: Glavni cilj ovog istraživanja je bio opisati osnovne osobine COVID-19 i prikazati njegovu pojavnost u Federaciji Bosne i Hercegovine. Metode: Rad je napisan kao deskriptivna studija, koja obuhvaća razdoblje od 21. 02. 2020. god do 01. 07. 2020. godine. Pregledom publikacija Zavoda za javno zdravstvo Federacije BiH prikupili su se podatci vezani za praćenja COVID-19 u Federaciji BiH. Rezultati: Od 21. 02. 2020. godine do 01. 07. 2020. godine napravljena su 62643 testa na Covid-19 u Federaciji Bosne i Hercegovine, a potvrđeno je 2901 testova. Ukupno je izliječeno 1272 osobe, a umrlih od COVID-19 bilo je 68 osoba. Od 21. 02. 2020. godine do 01. 07. 2020. godine najveći broj pozitivnih osoba na Covid- 19, njih 816 (28%), zabilježeno je u Tuzlanskom kantonu. Kanton Sarajevo zabilježio je 711 (25%) pozitivnih osoba na COVID-19, a Zeničko- dobojski kanton 536 (18%) osoba pozitivnih na COVID-19. U Bosansko-podriskom zabilježen je najmanji broj osoba pozitivnih na COVID-19, njih 44 (2%). Pregledom pozitivnih osoba na COVID-19 zabilježeno je 1430 (49, 29%) muškaraca i 1471 (50, 71%) žena. Primjenom Hi-kvadrat testa nije utvrđena statistički značajna razlika u odnosu na spol ispitanika (χ2= 0.579, p>0, 05). Najveći broj pozitivnih na COVID-19 bio je dobne skupine od 20 do 44 godine. Primjenom Hi-kvadrat testa utvrđena je statistički značajna razlika u odnosu na dob ispitanika (χ2=2114.32, p
- Published
- 2020
10. MRI of uterine fibroids: what interventional radiologist expect us to report before and after uterine fibroid embolization
- Author
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Kavelj, Ivana
- Subjects
Complications ,genetic structures ,MR-Angiography ,education ,Pathology ,Tissue characterisation ,Embolisation ,Interventional vascular ,MR ,MR-Diffusion/Perfusion ,Pelvis ,Genital / Reproductive system female - Abstract
Learning objectives Background Findings and procedure details Conclusion Personal information References, Learning objectives: To explain algorithm of uterine fibroid (UF) diagnostic assessment and follow-up management after embolization. To illustrate diversity of MRI characteristics of uterine fibroids. To demonstrate pictorial examples of UF before and after embolization...
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- 2019
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- View/download PDF
11. How can we improve prostate cancer detection on MRI – technical, clinical and imaging considerations
- Author
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Kavelj, Ivana
- Subjects
Genital / Reproductive system male ,MR physics ,genetic structures ,Oncology ,Neoplasia ,Biopsy ,education ,MR ,Imaging sequences ,Artifacts ,MR-Diffusion/Perfusion ,Structured reporting ,Cancer - Abstract
Learning objectives Background Findings and procedure details Conclusion Personal information References, Learning objectives: To explain significance of prostate MRI and reporting according to PI-RADS v2 system. To describe technical requirements needed to obtain best image quality. To demonstrate MRI analysis in context of clinical data and show some pictorial examples of...
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- 2019
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12. Buried bumper syndrome: where did that PEG tube go?!
- Author
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Kavelj, Ivana
- Subjects
Inflammation ,Complications ,genetic structures ,education ,Localisation ,Stomach (incl. Oesophagus) ,Gastrointestinal tract ,Contrast agent-oral ,Fluoroscopy ,Abdomen ,Obstruction / Occlusion ,Swallowing disorders ,CT ,Conventional radiography - Abstract
Learning objectives Background Findings and procedure details Conclusion Personal information References, Learning objectives: to get familiar with indications and procedure of percutaneous endoscopic gastrostomy (PEG) tube placement, to present possible procedure-related early and delayed complications that may occur accentuating imaging characteristics and to introduce...
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- 2018
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13. Percutaneous transthoracic CT guided biopsies – what have we found
- Author
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Kavelj, Ivana
- Subjects
genetic structures ,Oncology ,Epidemiology ,CT-High Resolution ,Biopsy ,PET-CT ,Tissue characterisation ,Thorax ,Localisation ,Diagnostic procedure ,Interventional non-vascular ,Cancer ,Percutaneous - Abstract
Aims and objectives Methods and materials Results Conclusion Personal information References, Aims and objectives: CT is superior radiological method for needle guidance/surveillance in order to achieve sufficient tissue specimens of thoracic lesions. Our aim was to present variety of patohistological diagnoses established after CT guided biopsies performed...
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- 2018
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14. Pancreatic Insulinoma - 'the little troublemaker' in diagnostic imaging
- Author
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Kavelj, Ivana, Bušić-Pavlek, Iva, Marinkić, Maja, Krpan, Tomislav, and Brnić, Zoran
- Subjects
Neoplasia, eLearning, Education, Diagnostic procedure, Ultrasound, MR, CT, Pancreas, Oncology, Abdomen ,genetic structures ,Neoplasia ,Oncology ,education ,Ultrasound ,Abdomen ,eLearning ,MR ,Diagnostic procedure ,Pancreas ,Education ,CT - Abstract
Learning objectives Background Findings and procedure details Conclusion Personal information References, Learning objectives: The purpose of our educational exhibit is to: explain the main characteristics of pancreatic insulinoma and its potential complications; give an overview of the imaging methods available for localization of insulinomas; describe main imaging...
- Published
- 2016
15. Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect.
- Author
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Kalogjera L, Krezic I, Smoday IM, Vranes H, Zizek H, Yago H, Oroz K, Vukovic V, Kavelj I, Novosel L, Zubcic S, Barisic I, Beketic Oreskovic L, Strbe S, Sever M, Sjekavica I, Skrtic A, Boban Blagaic A, Seiwerth S, and Sikiric P
- Subjects
- Rats, Animals, Rats, Wistar, Syndrome, Peptide Fragments pharmacology, Peptide Fragments therapeutic use, Hemorrhage, Stomach Diseases drug therapy, Stomach Diseases etiology, Anti-Ulcer Agents therapeutic use
- Abstract
Background: Using rat stomach perforation as a prototypic direct lesion applied in cytoprotection research, we focused on the first demonstration of the severe occlusion/ occlusion-like syndrome induced by stomach perforation. The revealed stomach-induced occlusion/occlusion-like syndrome corresponds to the previously described occlusion/occlusion-like syndromes in rats suffering multicausal pathology and shared severe vascular and multiorgan failure. This general point was particularly reviewed. As in all the described occlusion/occlusion-like syndromes with permanent occlusion of major vessels, peripheral and central, and other similar noxious procedures that severely affect endothelium function, the stable gastric pentadecapeptide BPC 157 was resolving therapy., Aim: To reveal the stomach perforation-induced general occlusion/occlusion-like syndrome and BPC 157 therapy effect., Methods: The procedure included deeply anesthetized rats, complete calvariectomy, laparotomy at 15 min thereafter, and stomach perforation to rapidly induce vascular and multiorgan failure occlusion/occlusion-like syndrome. At 5 min post-perforation time, rats received therapy [BPC 157 (10 µg or 10 ng/kg) or saline (5 mL/kg, 1 mL/rat) (controls)] into the perforated defect in the stomach). Sacrifice was at 15 min or 60 min post-perforation time. Assessment (gross and microscopy; volume) included: Brain swelling, peripheral vessels (azygos vein, superior mesenteric vein, portal vein, inferior caval vein) and heart, other organs lesions ( i.e., stomach, defect closing or widening); superior sagittal sinus, and peripherally the portal vein, inferior caval vein, and abdominal aorta blood pressures and clots; electrocardiograms; and bleeding time from the perforation(s)., Results: BPC 157 beneficial effects accord with those noted before in the healing of the perforated defect (raised vessel presentation; less bleeding, defect contraction) and occlusion/occlusion-like syndromes counteraction. BPC 157 therapy (into the perforated defect), induced immediate shrinking and contraction of the whole stomach (unlike considerable enlargement by saline application). Accordingly, BPC 157 therapy induced direct blood delivery via the azygos vein, and attenuated/eliminated the intracranial (superior sagittal sinus), portal and caval hypertension, and aortal hypotension. Thrombosis, peripherally (inferior caval vein, portal vein, abdominal aorta) and centrally (superior sagittal sinus) BPC 157 therapy markedly reduced/annihilated. Severe lesions in the brain (swelling, hemorrhage), heart (congestion and arrhythmias), lung (hemorrhage and congestion), and marked congestion in the liver, kidney, and gastrointestinal tract were markedly reduced., Conclusion: We revealed stomach perforation as a severe occlusion/occlusion-like syndrome, peripherally and centrally, and rapid counteraction by BPC 157 therapy. Thereby, further BPC 157 therapy may be warranted., Competing Interests: Conflict-of-interest statement: Authors declare no conflict of interest., (©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
16. CURRENT ROLE OF MAGNETIC RESONANCE IMAGING IN THE SCREENING, DIAGNOSIS, AND TREATMENT OF PROSTATE CANCER.
- Author
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Nikles S, Pezelj I, Tomić M, Knežević M, Vrhovec B, Dumbović L, Pirša M, Kavelj I, and Tomašković I
- Subjects
- Male, Humans, Reproducibility of Results, Magnetic Resonance Imaging methods, Prostate-Specific Antigen, Image-Guided Biopsy methods, Early Detection of Cancer methods, Prostatic Neoplasms diagnostic imaging, Prostatic Neoplasms therapy
- Abstract
Prostate cancer is the most common cancer in men. Diagnosis of prostate cancer poses a significant challenge, due to several different key parameters that need to be evaluated, such as age, history of prostate specific antigen (PSA), clinical examination and more recently magnetic resonance imaging (MRI). The current diagnostic pathway for prostate cancer has resulted in overdiagnosis and overtreatment as well as underdiagnosis and missed diagnoses in many men. Multiparametric MRI (mp-MRI) of the prostate has been identified as a test that could alleviate these diagnostic errors. Before prostate cancer treatment pathological confirmation is mandatory. Prostate biopsy is an invasive procedure with rare but not negligible potential complications. There are several methods of prostate biopsy of which most common are systemic or planar prostate biopsy and cognitive or targeted MRI-guided prostate biopsy. Multiparametric MRI has demonstrated better accuracy and reproducibility in detecting, locating and evaluating prostate cancer and also sparing some men unnecessary biopsies. Recent studies have shown a mpMRI benefit for better procedure planning regarding prostate cancer location, extent of disease and length of the urethra. There are still some challenges ahead, such as ensuring high-quality execution and reporting of mpMRI and ensuring that this diagnostic pathway is cost-effective. According to the latest urological clinical guidelines mpMRI became fundamental tool in management of prostate cancer. The aim of this study is to give a brief insight in use of mpMRI in prostate cancer diagnosis and treatment.
- Published
- 2022
- Full Text
- View/download PDF
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