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2. Eosinophilic asthma

Author

Rupani, Hitasha, primary, Gates, Jessica, additional, Kavanagh, Joanne E., additional, and Jackson, David J., additional

Published
2022
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4. Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lim, Kaiser, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molassoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., and Ireland, Belinda

Published
2020
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5. Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Blackhall, Fiona, Birring, Surinder S., Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lim, Kaiser, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., and Oppenheimer, John J.

Published
2020
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6. Managing Chronic Cough Due to Asthma and NAEB in Adults and Adolescents: CHEST Guideline and Expert Panel Report

Author

Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Bolser, Donald C., Birring, Surinder S., Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Gibson, Peter, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Moore, Abigail, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, Côté, Andreanne, Boulet, Louis-Philippe, Gibson, Peter G., and Brightling, Christopher E.

Published
2020
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7. Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients: CHEST Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Birring, Surinder S., Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Lai, Kefang, Lilly, Craig, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, Ireland, Belinda, and Linder, Jeffrey A.

Published
2020
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9. Chronic Cough and Gastroesophageal Reflux in Children: CHEST Guideline and Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Bolser, Donald C., Birring, Surinder S., Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Gibson, Peter, Harding, Susan M., Gold, Philip, Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Lai, Kefang, Lim, Kaiser, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Metlay, Joshua P., Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Turmel, Julie, Vertigan, Anne E., Weinberger, Miles, Oppenheimer, John J., Kantar, Ahmad, and Rubin, Bruce K.

Published
2019
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11. Clinically Diagnosing Pertussis-associated Cough in Adults and Children: CHEST Guideline and Expert Panel Report

Author

Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Bolser, Donald C., Birring, Surinder S., Blackwell, Fiona, Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Gibson, Peter, Gold, Philip, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Moore, Abigail, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Nguyen, Huong Q., Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, Grant, Cameron C., and Patel, Sheena

Published
2019
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12. Adult Outpatients With Acute Cough Due to Suspected Pneumonia or Influenza: CHEST Guideline and Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Gold, Philip, Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Moore, Abigail, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Nguyen, Huong Q., Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Turmel, Julie, Vertigan, Anne E., Wang, Gang, Weinberger, Miles, Gold, Philip M., Metlay, Joshua P., and Ireland, Belinda

Published
2019
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13. The impact of steroid-sparing biologic therapies on weight loss in obese individuals with severe eosinophilic asthma

Author

Nanzer, Alexandra M, primary, Taylor, Victoria, additional, Hearn, Andrew P, additional, Kavanagh, Joanne E, additional, Patrick, Tanya, additional, Green, Linda, additional, Thomson, Louise, additional, Lam, Jodie, additional, Fernandez, Mariana, additional, Roxas, Cris, additional, d'Ancona, Grainne, additional, Kent, Brian D, additional, Dhariwal, Jaideep, additional, and Jackson, David J, additional

Published
2023
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16. Classification of Cough as a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report

Author

Irwin, Richard S., French, Cynthia L., Chang, Anne B., Altman, Kenneth W., Adams, Todd M., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Brightling, Christopher, Callahan-Lyon, Priscilla, Cowley, Terrie, Ebihara, Satoru, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Gold, Philip, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Madison, Mark J., Malesker, Mark A., Mazzone, Stuart, Molassoitis, Alex, Murad, Hassan M., Narasimhan, Mangala, Nguyen, Huong Q., Newcombe, Peter, Oppenheimer, John, Restrepo, Marcos I., Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Tarlo, Susan M., Turmel, Julie, Vertigan, Anne E., Wang, Gang, and Weinberger, Miles

Published
2018
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17. Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold: CHEST Expert Panel Report

Author

Malesker, Mark A., Callahan-Lyon, Priscilla, Ireland, Belinda, Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Chang, Anne B., Coté, Andréanne, Cowley, Terrie, Davenport, Paul, Ebihara, Satoru, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Gibson, Peter, Gold, Philip, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Madison, Mark J., Mazzone, Stuart, McGarvey, Lorcan, Molassoitis, Alex, Murad, Hassan M., Narasimhan, Mangala, Newcombe, Peter, Nguyen, Huong Q., Oppenheimer, John, Restrepo, Marcos I., Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Smith, Jaclyn, Tarlo, Susan M., Turmel, Julie, Vertigan, Anne E., Wang, Gang, Weinberger, Miles, and Weir, Kelly

Published
2017
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20. Global Physiology and Pathophysiology of Cough

Author

McGarvey, Lorcan, primary, Rubin, Bruce K., additional, Ebihara, Satoru, additional, Hegland, Karen, additional, Rivet, Alycia, additional, Irwin, Richard S., additional, Bolser, Donald C., additional, Chang, Anne B., additional, Gibson, Peter G., additional, Mazzone, Stuart B., additional, Altman, Kenneth W., additional, Barker, Alan F., additional, Birring, Surinder S., additional, Blackhall, Fiona, additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Coté, Andréanne, additional, Gibson, Peter, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Hill, Adam T., additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Keogh, Karina A., additional, Lane, Andrew P., additional, Madison, J. Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Newcombe, Peter, additional, Oppenheimer, John, additional, Rubin, Bruce, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, and Vertigan, Anne E., additional

Published
2021
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21. Global Physiology and Pathophysiology of Cough: Part 1: Cough Phenomenology – CHEST Guideline and Expert Panel Report

Author

Lee, Kai K., Davenport, Paul, Smith, Jaclyn A., Irwin, Richard S., McGarvey, Lorcan, Mazzone, Stuart B., Birring, Surinder S., Abu Dabrh, Abd Moain, Altman, Kenneth W., Barker, Alan F., Blackhall, Fiona, Bolser, Donald C., Brightling, Christopher, Chang, Anne B., El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Iyer, Vivek, Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Madison, J. Mark, Malesker, Mark A., Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., other, and, Lee, Kai K., Davenport, Paul, Smith, Jaclyn A., Irwin, Richard S., McGarvey, Lorcan, Mazzone, Stuart B., Birring, Surinder S., Abu Dabrh, Abd Moain, Altman, Kenneth W., Barker, Alan F., Blackhall, Fiona, Bolser, Donald C., Brightling, Christopher, Chang, Anne B., El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Iyer, Vivek, Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Madison, J. Mark, Malesker, Mark A., Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., and other, and

Abstract

The purpose of this state-of-the-art review is to update the American College of Chest Physicians 2006 guideline on global physiology and pathophysiology of cough. A review of the literature was conducted using PubMed and MEDLINE databases from 1951 to 2019 and using prespecified search terms. We describe the basic phenomenology of cough patterns, behaviors, and morphological features. We update the understanding of mechanical and physiological characteristics of cough, adding a contemporary view of the types of cough and their associated behaviors and sensations. New information about acoustic characteristics is presented, and recent insights into cough triggers and the patient cough hypersensitivity phenotype are explored. Lastly, because the clinical assessment of patients largely focuses on the duration rather than morphological features of cough, we review the morphological features of cough that can be measured in the clinic. This is the first of a two-part update to the American College of Chest Physicians 2006 cough guideline; it provides a more global consideration of cough phenomenology, beyond simply the mechanical aspects of a cough. A greater understanding of the typical features of cough, and their variations, may allow a more informed interpretation of cough measurements and the clinical relevance for patients.

Published
2021

22. Real world effectiveness of anti-IL-5/5R therapies is independent of co-eligibility for anti-IgE therapy

Author

Hearn, Andrew P., primary, Hug, Oliver D., additional, Somani, Ziana A., additional, Kavanagh, Joanne, additional, d'Ancona, Grainne, additional, Roxas, Cris, additional, Green, Linda, additional, Thomson, Louise, additional, Fernandes, Mariana, additional, Kent, Brian D., additional, Dhariwal, Jaideep, additional, Nanzer, Alexandra M., additional, and Jackson, David J., additional

Published
2021
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23. Real-World Effectiveness of Benralizumab in Severe Eosinophilic Asthma

Author

Kavanagh, Joanne E., primary, Hearn, Andrew P., additional, Dhariwal, Jaideep, additional, d’Ancona, Gráinne, additional, Douiri, Abdel, additional, Roxas, Cris, additional, Fernandes, Mariana, additional, Green, Linda, additional, Thomson, Louise, additional, Nanzer, Alexandra M., additional, Kent, Brian D., additional, and Jackson, David J., additional

Published
2021
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24. Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients: CHEST Expert Panel Report

Author

Smith, Maeve P., Lown, Mark, Singh, Sonal, Ireland, Belinda, Hill, Adam T., Linder, Jeffrey A., Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Birring, Surinder S., Bolser, Donald C., Boulet, Louis Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Kahrilas, Peter J., Kavanagh, Joanne, Lai, Kefang, Lilly, Craig, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Smith, Jaclyn, Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, other, and, Smith, Maeve P., Lown, Mark, Singh, Sonal, Ireland, Belinda, Hill, Adam T., Linder, Jeffrey A., Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Birring, Surinder S., Bolser, Donald C., Boulet, Louis Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Kahrilas, Peter J., Kavanagh, Joanne, Lai, Kefang, Lilly, Craig, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Smith, Jaclyn, Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, and other, and

Abstract

Background: Evidence for the diagnosis and management of cough due to acute bronchitis in immunocompetent adult outpatients was reviewed as an update to the 2006 “Chronic Cough Due to Acute Bronchitis: American College of Chest Physicians (ACCP) Evidence-Based Clinical Practice Guidelines.” Methods: Acute bronchitis was defined as an acute lower respiratory tract infection manifested predominantly by cough with or without sputum production, lasting no more than 3 weeks with no clinical or any recent radiographic evidence to suggest an alternative explanation. Two clinical population, intervention, comparison, outcome questions were addressed by systematic review in July 2017: (1) the role of investigations beyond the clinical assessment of patients presenting with suspected acute bronchitis, and (2) the efficacy and safety of prescribing medication for cough in acute bronchitis. An updated search was undertaken in May 2018. Results: No eligible studies relevant to the first question were identified. For the second question, only one relevant study met eligibility criteria. This study found no difference in number of days with cough between patients treated with an antibiotic or an oral nonsteroidal antiinflammatory agent compared with placebo. Clinical suggestions and research recommendations were made based on the consensus opinion of the CHEST Expert Cough Panel. Conclusions: The panelists suggested that no routine investigations be ordered and no routine medications be prescribed in immunocompetent adult outpatients first presenting with cough due to suspected acute bronchitis, until such investigations and treatments have been shown to be safe and effective at making cough less severe or resolve sooner. If the cough due to suspected acute bronchitis persists or worsens, a reassessment and consideration of targeted investigations should be considered.

Published
2020

25. Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report

Author

Malesker, Mark A., Callahan-Lyon, Priscilla, Madison, J. Mark, Ireland, Belinda, Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis Philippe, Braman, Sidney S., Brightling, Christopher, Chang, Anne B., Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lim, Kaiser, Lown, Mark, Mazzone, Stuart, McGarvey, Lorcan, Molassoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Malesker, Mark A., Callahan-Lyon, Priscilla, Madison, J. Mark, Ireland, Belinda, Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis Philippe, Braman, Sidney S., Brightling, Christopher, Chang, Anne B., Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lim, Kaiser, Lown, Mark, Mazzone, Stuart, McGarvey, Lorcan, Molassoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., and Vertigan, Anne E.

Abstract

Background: Chronic cough due to chronic bronchitis (CB) causes significant impairment in quality of life, and effective treatment strategies are needed. We conducted a systematic review on the management of chronic cough due to CB to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline on this topic. Methods: This systematic review asked three questions: (1) What are the clinical features of the history that suggest a patient's cough-phlegm syndrome is due to CB? (2) Can treatment of stable CB improve or eliminate chronic cough? (3) Can therapy that targets chronic cough due to CB prevent or reduce the occurrence of acute CB exacerbations? Studies of adult patients with CB were included and assessed for relevance and quality. Based on the systematic review, guideline suggestions were developed and voted on by using the CHEST organization methodology. Results: The search strategy used an assortment of descriptors and assessments to identify studies of chronic cough due to CB. Conclusions: The evidence supporting the management of chronic cough due to CB is limited overall and of low quality. This article provides guidance on treatment by presenting suggestions based on the best currently available evidence and identifies gaps in our knowledge and areas for future research.

Published
2020

26. Managing Chronic Cough Due to Asthma and NAEB in Adults and Adolescents: CHEST Expert Panel Report

Author

Côté, Andreanne, Russell, Richard J., Boulet, Louis Philippe, Gibson, Peter G., Lai, Kefang, Irwin, Richard S., Brightling, Christopher, Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Bolser, Donald C., Birring, Surinder S., Braman, Sidney S., Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kahrilas, Peter J., Kavanagh, Joanne, Lane, Andrew P., Lilly, Craig, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Moore, Abigail, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, other, and, Côté, Andreanne, Russell, Richard J., Boulet, Louis Philippe, Gibson, Peter G., Lai, Kefang, Irwin, Richard S., Brightling, Christopher, Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Bolser, Donald C., Birring, Surinder S., Braman, Sidney S., Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kahrilas, Peter J., Kavanagh, Joanne, Lane, Andrew P., Lilly, Craig, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Moore, Abigail, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, and other, and

Abstract

Background: Asthma and non-asthmatic eosinophilic bronchitis (NAEB) are among the commonest causes of chronic cough in adults. We sought to determine the role of non-invasive measurements of airway inflammation, including induced sputum and fractional exhaled nitric oxide, in the evaluation of cough associated with asthma, and what the best treatment is for cough due to asthma or NAEB. Methods: We undertook three systematic reviews of randomized controlled trials and observational trials of adults and adolescents > 12 years of age with a chronic cough due to asthma or NAEB. Eligible studies were identified in MEDLINE, CENTRAL, and SCOPUS and assessed for relevance and quality. Guidelines were developed and voted upon using CHEST guideline methodology. Results: Of the citations reviewed, 3/1,175, 53/656, and 6/134 were identified as being eligible for inclusion in the three systematic reviews, respectively. In contrast to established guidelines for asthma therapies in general and the inclusion in some guidelines for a role of biomarkers of airway inflammation to guide treatment in severe disease, the evidence of specific benefit related to the use of non-invasive biomarkers in patients with chronic cough due to asthma was weak. The best therapeutic option for cough in asthma or NAEB is inhaled corticosteroids followed by leukotriene receptor antagonism. Conclusions: This guideline offers recommendations on the role of non-invasive measurements of airway inflammation and treatment for cough due to asthma or NAEB based on the available literature, and identifies gaps in knowledge and areas for future research.

Published
2020

27. Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report

Author

Chang, Anne B., Oppenheimer, John, Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Blackhall, Fiona, Birring, Surinder S., Bolser, Donald C., Boulet, Louis Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lim, Kaiser, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., other, and, Chang, Anne B., Oppenheimer, John, Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Blackhall, Fiona, Birring, Surinder S., Bolser, Donald C., Boulet, Louis Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lim, Kaiser, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., and other, and

Abstract

Background: Cough is one of the most common presenting symptoms to general practitioners. The objective of this article is to collate the pediatric components of the CHEST chronic cough guidelines that have recently updated the 2006 guidelines to assist general and specialist medical practitioners in the evaluation and management of children who present with chronic cough. Methods: We reviewed all current CHEST Expert Cough Panel's statements and extracted recommendations and suggestions relating to children aged ≤ 14 years with chronic cough (> 4 weeks duration). Additionally, we undertook systematic reviews to update other sections we considered relevant and important. Results: The eight recent CHEST guidelines relevant to children, based on systematic reviews, reported some high-quality evidence in the management of chronic cough in children (eg, use of algorithms and management of wet/productive cough using appropriate antibiotics). However, much evidence is still inadequate, particularly in the management of non-specific cough in the community. Conclusions: The recommendations and suggestions related to the management of chronic cough in the pediatric age group have been based upon high-quality systematic reviews and are summarized in this article. Compared to the 2006 Cough Guidelines, there is now high-quality evidence for some aspects of the management of chronic cough in children. However, further studies particularly in primary health care are required.

Published
2020

28. Adherence to inhaled corticosteroids and clinical outcomes following a year of benralizumab therapy for severe eosinophilic asthma

Author

d'Ancona, Grainne, primary, Kavanagh, Joanne E., additional, Dhariwal, Jaideep, additional, Hearn, Andrew P., additional, Roxas, Cris, additional, Fernandes, Mariana, additional, Green, Linda, additional, Thomson, Louise, additional, Nanzer, Alexandra M., additional, Jackson, David J., additional, and Kent, Brian D., additional

Published
2021
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29. Global Physiology and Pathophysiology of Cough

Author

Lee, Kai K., primary, Davenport, Paul W., additional, Smith, Jaclyn A., additional, Irwin, Richard S., additional, McGarvey, Lorcan, additional, Mazzone, Stuart B., additional, Birring, Surinder S., additional, Abu Dabrh, AbdMoain, additional, Altman, Kenneth W., additional, Barker, Alan F., additional, Blackhall, Fiona, additional, Bolser, Donald C., additional, Brightling, Christopher, additional, Chang, Anne B., additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Hill, AdamT., additional, Iyer, Vivek, additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Keogh, Karina A., additional, Lai, Kefang, additional, Lane, AndrewP., additional, Lim, Kaiser, additional, Madison, J. Mark, additional, Malesker, MarkA., additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Newcombe, Peter, additional, Oppenheimer, John, additional, Rubin, Bruce, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, and Vertigan, Anne E., additional

Published
2021
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31. Response

Author

Kavanagh, Joanne E., primary and Jackson, David J., additional

Published
2020
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32. Life-Threatening and Non-Life-Threatening Complications Associated With Coughing

Author

Irwin, Richard S., primary, Dudiki, Natasha, additional, French, Cynthia L., additional, Abu Dabrh, Abd Moain, additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Barker, Alan F., additional, Birring, Surinder S., additional, Bolser, Donald C., additional, Boulet, Louis-Philippe, additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Canning, Brendan, additional, Chang, Anne B., additional, Cowley, Terrie, additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Hill, Adam T., additional, Irwin, Richard S., additional, Iyer, Vivek, additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Keogh, Karina A., additional, Lai, Kefang, additional, Lane, Andrew P., additional, Lim, Kaiser, additional, Madison, J. Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Molasoitis, Alex, additional, Moore, Abigail, additional, Murad, M. Hassan, additional, Newcombe, Peter, additional, Oppenheimer, John, additional, Rubin, Bruce, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Jaclyn, additional, Tarlo, Susan M., additional, and Vertigan, Anne E., additional

Published
2020
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33. Steroid-sparing effects of benralizumab in patients with eosinophilic granulomatosis with polyangiitis

Author

Nanzer, Alexandra M., primary, Dhariwal, Jaideep, additional, Kavanagh, Joanne, additional, Hearn, Andrew, additional, Fernandes, Mariana, additional, Thomson, Louise, additional, Roxas, Cris, additional, Green, Linda, additional, D'Ancona, Grainne, additional, Agarwal, Sangita, additional, Kent, Brian D., additional, and Jackson, David J., additional

Published
2020
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34. Super-responder analysis and real-world one year effectiveness of benralizumab in severe eosinophilic asthma

Author

Kavanagh, Joanne, primary, Roxas, Cris, additional, Green, Linda, additional, Fernandes, Mariana, additional, Thomson, Louise, additional, Payne, Victoria, additional, Hearn, Andrew, additional, Kent, Brian D, additional, D'Ancona, Grainne, additional, Dhariwal, Jaideep, additional, Nanzer, Alexandra M A, additional, and Jackson, David J, additional

Published
2020
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35. Determining early response to anti-IL5/IL5R monoclonal antibodies in severe eosinophilic asthma

Author

Kavanagh, Joanne, primary, Roxas, Cris, additional, Green, Linda, additional, Fernandes, Mariana, additional, Thomson, Louise, additional, Payne, Victoria, additional, Hearn, Andrew, additional, Kent, Brian D, additional, D'Ancona, Grainne, additional, Dhairwal, Jaideep, additional, Nanzer, Alexandra M, additional, and Jackson, David J, additional

Published
2020
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36. Relationship between baseline fraction of exhaled nitric oxide (FeNO) and response to anti-IL-5/5R therapies in severe eosinophilic asthma (SEA)

Author

Kavanagh, Joanne, primary, Hearn, Andrew, additional, Roxas, Cris, additional, Green, Linda, additional, Fernandes, Marianna, additional, Thomson, Louise, additional, Payne, Victoria, additional, D'Ancona, Grainne, additional, Kent, Brian, additional, Dhariwal, Jaideep, additional, Nanzer-Kelly, Alexandra, additional, and Jackson, David, additional

Published
2020
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37. Chronic Cough Due to Stable Chronic Bronchitis

Author

Malesker, Mark A., primary, Callahan-Lyon, Priscilla, additional, Madison, J. Mark, additional, Ireland, Belinda, additional, Irwin, Richard S., additional, Adams, Todd M., additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Barker, Alan F., additional, Birring, Surinder S., additional, Blackhall, Fiona, additional, Bolser, Donald C., additional, Boulet, Louis-Philippe, additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Chang, Anne B., additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Gibson, Peter, additional, Grant, Cameron, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Hill, Adam T., additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Keogh, Karina A., additional, Lai, Kefang, additional, Lane, Andrew P., additional, Lilly, Craig, additional, Lim, Kaiser, additional, Lown, Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Molassoitis, Alex, additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Oppenheimer, John, additional, Rosen, Mark, additional, Rubin, Bruce, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, and Vertigan, Anne E., additional

Published
2020
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38. Managing Chronic Cough Due to Asthma and NAEB in Adults and Adolescents

Author

Côté, Andreanne, primary, Russell, Richard J., additional, Boulet, Louis-Philippe, additional, Gibson, Peter G., additional, Lai, Kefang, additional, Irwin, Richard S., additional, Brightling, Christopher E., additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Barker, Alan F., additional, Blackhall, Fiona, additional, Bolser, Donald C., additional, Birring, Surinder S., additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Callahan-Lyon, Priscilla, additional, Chang, Anne B., additional, Cowley, Terrie, additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Gibson, Peter, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Hill, Adam T., additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Lane, Andrew P., additional, Lilly, Craig, additional, Lown, Mark, additional, Madison, J. Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Molasoitis, Alex, additional, Moore, Abigail, additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Oppenheimer, John, additional, Rosen, Mark, additional, Rubin, Bruce, additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Jaclyn, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, Vertigan, Anne E., additional, and Weinberger, Miles, additional

Published
2020
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39. Managing Chronic Cough as a Symptom in Children and Management Algorithms

Author

Chang, Anne B., primary, Oppenheimer, John J., additional, Irwin, Richard S., additional, Adams, Todd M., additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Blackhall, Fiona, additional, Birring, Surinder S., additional, Bolser, Donald C., additional, Boulet, Louis-Philippe, additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Callahan-Lyon, Priscilla, additional, Chang, Anne B., additional, Cowley, Terrie, additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Hill, Adam T., additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Keogh, Karina A., additional, Lai, Kefang, additional, Lane, Andrew P., additional, Lilly, Craig, additional, Lim, Kaiser, additional, Lown, Mark, additional, Madison, J. Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Molasoitis, Alex, additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Oppenheimer, John, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, and Vertigan, Anne E., additional

Published
2020
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40. Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients

Author

Smith, Maeve P., primary, Lown, Mark, additional, Singh, Sonal, additional, Ireland, Belinda, additional, Hill, Adam T., additional, Linder, Jeffrey A., additional, Irwin, Richard S., additional, Adams, Todd M., additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Barker, Alan F., additional, Blackhall, Fiona, additional, Birring, Surinder S., additional, Bolser, Donald C., additional, Boulet, Louis-Philippe, additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Callahan-Lyon, Priscilla, additional, Chang, Anne B., additional, Cowley, Terrie, additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Lai, Kefang, additional, Lilly, Craig, additional, Madison, J. Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Molasoitis, Alex, additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Newcombe, Peter, additional, Oppenheimer, John, additional, Rosen, Mark, additional, Rubin, Bruce, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Smith, Jaclyn, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, Vertigan, Anne E., additional, and Weinberger, Miles, additional

Published
2020
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43. Chronic cough and gastroesophageal reflux in children: Chest guideline and expert panel report

Author

Chang, Anne B., Oppenheimer, John, Kahrilas, Peter J., Kantar, Ahmad, Rubin, Bruce, Weinberger, Miles, Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Bolser, Donald C., Birring, Surinder S., Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Gibson, Peter, Harding, Susan M., Gold, Philip, Harnden, Anthony, Hill, Adam T., Kavanagh, Joanne, Lai, Kefang, Lim, Kaiser, Mark Madison, J., Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Metlay, Joshua P., Molasoitis, Alex, Hassan Murad, M., Narasimhan, Mangala, Newcombe, Peter, Rosen, Mark, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Turmel, Julie, Vertigan, Anne E., other, and, Chang, Anne B., Oppenheimer, John, Kahrilas, Peter J., Kantar, Ahmad, Rubin, Bruce, Weinberger, Miles, Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Bolser, Donald C., Birring, Surinder S., Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Gibson, Peter, Harding, Susan M., Gold, Philip, Harnden, Anthony, Hill, Adam T., Kavanagh, Joanne, Lai, Kefang, Lim, Kaiser, Mark Madison, J., Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Metlay, Joshua P., Molasoitis, Alex, Hassan Murad, M., Narasimhan, Mangala, Newcombe, Peter, Rosen, Mark, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Turmel, Julie, Vertigan, Anne E., and other, and

Abstract

BACKGROUND: Whether gastroesophageal reflux (GER) or GER disease (GERD) causes chronic cough in children is controversial. Using the Population, Intervention, Comparison, Outcome (PICO) format, we undertook four systematic reviews. For children with chronic cough (> 4-weeks duration) and without underlying lung disease: (1) who do not have gastrointestinal GER symptoms, should empirical treatment for GERD be used? (2) with gastrointestinal GER symptoms, does treatment for GERD resolve the cough? (3) with or without gastrointestinal GER symptoms, what GER-based therapies should be used and for how long? (4) if GERD is suspected as the cause, what investigations and diagnostic criteria best determine GERD as the cause of the cough? METHODS: We used the CHEST Expert Cough Panel's protocol and American College of Chest Physicians (CHEST) methodological guidelines and GRADE (Grading of Recommendations Assessment, Development and Evaluation) framework. Delphi methodology was used to obtain consensus. RESULTS: Few randomized controlled trials addressed the first two questions and none addressed the other two. The single meta-analysis (two randomized controlled trials) showed no significant difference between the groups (any intervention for GERD vs placebo for cough resolution; OR, 1.14; 95% CI, 0.45-2.93; P ¼.78). Proton pump inhibitors (vs placebo) caused increased serious adverse events. Qualitative data from existing CHEST cough systematic reviews were consistent with two international GERD guidelines. CONCLUSIONS: The panelists endorsed that: (1) treatment(s) for GERD should not be used when there are no clinical features of GERD; and (2) pediatric GERD guidelines should be used to guide treatment and investigations.

Published
2019

44. Benralizumab after sub‐optimal response to mepolizumab in severe eosinophilic asthma.

Author

Kavanagh, Joanne E., Hearn, Andrew P., d'Ancona, Grainne, Dhariwal, Jaideep, Roxas, Cris, Green, Linda, Thomson, Louise, Fernandes, Mariana, Kent, Brian D., Nanzer, Alexandra M., and Jackson, David J.

Subjects
*ASTHMA, *ANTIBODY-dependent cell cytotoxicity
Abstract

Mepolizumab and benralizumab are monoclonal antibodies (mAb) directed against anti-IL-5 and anti-IL5R, respectively, and their use reduces exacerbation rate and maintenance oral corticosteroid (mOCS) requirements in severe eosinophilic asthma (SEA).1-4 We recently reported that a minority of patients treated with mepolizumab experience a sub-optimal response including those with a higher baseline ACQ and mOCS requirement.1 It remains unclear if such patients may improve following a switch to benralizumab which provides a more complete depletion of airway eosinophils.5,6 We retrospectively assessed patients with SEA treated at our specialist centre, who were switched from mepolizumab to benralizumab following a sub-optimal response defined as failing to achieve either: >=50% reduction in mOCS dose; >=50% reduction in annualized exacerbation rate (AER);and an ongoing requirement of >=7.5 mg prednisolone/day or an AER of >=3. In essence this notion is no different from the reality that within severe eosinophilic asthma, some patients require low dose maintenance oral steroids, whilst others require a higher dose to adequately suppress their airways inflammation. Our results appear to support this possibility and suggest that a more profound depletion in airway eosinophilia as occurs with benralizumab may offer additional clinical benefit in patients with particularly severe eosinophilic asthma. Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone-dependent severe asthma. [Extracted from the article]

Published
2021
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45. Treatment of Interstitial Lung Disease Associated Cough

Author

Birring, Surinder S., primary, Kavanagh, Joanne E., additional, Irwin, Richard S., additional, Keogh, Karina A., additional, Lim, Kaiser G., additional, Ryu, Jay H., additional, Adams, Todd M., additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Barker, Alan F., additional, Birring, Surinder S., additional, Blackhall, Fiona, additional, Boulet, Louis-Philippe, additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Callahan-Lyon, Priscilla, additional, Chang, Anne B., additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Harding, Susan M., additional, Gold, Philip, additional, Harnden, Anthony, additional, Hill, Adam T., additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Lai, Kefang, additional, Lane, Andrew P., additional, Lim, Kaiser, additional, Madison, J. Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Molasoitis, Alex, additional, Moore, Abigail, additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Nguyen, Huong Q., additional, Newcombe, Peter, additional, Oppenheimer, John, additional, Restrepo, Marcos I., additional, Rosen, Mark, additional, Rubin, Bruce, additional, Singh, Sonal, additional, Smith, Jaclyn, additional, Tarlo, Susan M., additional, Turmel, Julie, additional, Vertigan, Anne E., additional, Wang, Gang, additional, and Weinberger, Miles, additional

Published
2018
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46. Treatment of Interstitial Lung Disease associated cough:CHEST guideline and expert panel report

Author

Birring, Surinder S., Kavanagh, Joanne E., Irwin, Richard S., Keogh, Karina, Lim, Kaiser G., and Ryu, Jay H.

Subjects
interstitial lung disease, refractory, unexplained, treatment, chronic cough, scleroderma, sarcoidosis, respiratory system, respiratory tract diseases
Abstract

Background Chronic cough in interstitial lung disease (ILD) causes significant impairment in quality of life. Effective treatment approaches are needed for cough associated with ILD. Methods This systematic review asked: Is there evidence of clinically relevant treatment effects for therapies for cough in ILD? Studies of adults aged > 18 years with a chronic cough > 8 weeks duration were included and assessed for relevance and quality. Based on the systematic review, guideline suggestions were developed and voted on by using CHEST guideline methodology. Results Eight Randomized Controlled Trials (RCT) and 2 case series (>10 patients) were included that reported data on patients with Idiopathic Pulmonary fibrosis (IPF), Sarcoidosis and Scleroderma-related ILD who received a variety of interventions. Study quality was high in all 8 RCTs. Inhaled corticosteroids were not supported for cough associated with Sarcoidosis. Cyclophosphamide and Mycophenolate were not supported for solely treating cough associated with scleroderma associated ILD. A recommendation for thalidomide to treat cough associated with IPF did not pass the panel vote. In view of the paucity of antitussive treatment options for refractory cough in ILD, the guideline panel suggested that the CHEST unexplained cough guideline be followed, by considering options such as the neuromodulator gabapentin and speech pathology management. Opiates were also suggested for patients with cough refractory to alternative therapies. Conclusions The evidence supporting the management of chronic cough in ILD is limited. This guideline presents suggestions for managing and treating cough on the best available evidence but future research is clearly needed.

Published
2018

49. Chronic Cough and Gastroesophageal Reflux in Children

Author

Chang, Anne B., primary, Oppenheimer, John J., additional, Kahrilas, Peter J., additional, Kantar, Ahmad, additional, Rubin, Bruce K., additional, Weinberger, Miles, additional, Irwin, Richard S., additional, Adams, Todd M., additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Barker, Alan F., additional, Bolser, Donald C., additional, Birring, Surinder S., additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Callahan-Lyon, Priscilla, additional, Chang, Anne B., additional, Cowley, Terrie, additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Gibson, Peter, additional, Harding, Susan M., additional, Gold, Philip, additional, Harnden, Anthony, additional, Hill, Adam T., additional, Kavanagh, Joanne, additional, Lai, Kefang, additional, Lim, Kaiser, additional, Madison, J. Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Metlay, Joshua P., additional, Molasoitis, Alex, additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Newcombe, Peter, additional, Oppenheimer, John, additional, Rosen, Mark, additional, Rubin, Bruce, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Jaclyn, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, Turmel, Julie, additional, and Vertigan, Anne E., additional

Published
2019
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50. Response

Author

Hill, Adam T., primary, Gold, Philip M., additional, El Solh, Ali A., additional, Metlay, Joshua P., additional, Ireland, Belinda, additional, Irwin, Richard S., additional, Adams, Todd M., additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Barker, Alan F., additional, Birring, Surinder S., additional, Blackhall, Fiona, additional, Bolser, Donald C., additional, Boulet, Louis-Philippe, additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Callahan-Lyon, Priscilla, additional, Chang, Anne B., additional, Cowley, Terrie, additional, Davenport, Paul, additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Gibson, Peter, additional, Gold, Philip, additional, Grant, Cameron, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Hill, Adam T., additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Keogh, Karina A., additional, Lai, Kefang, additional, Lane, Andrew P., additional, Lim, Kaiser, additional, Madison, J. Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Molasoitis, Alex, additional, Moore, Abigail, additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Newcombe, Peter, additional, Nguyen, Huong Q., additional, Oppenheimer, John, additional, Rosen, Mark, additional, Rubin, Bruce, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Jaclyn, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, Turmel, Julie, additional, Vertigan, Anne E., additional, Wang, Gang, additional, and Weinberger, Miles, additional

Published
2019
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