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Background Objective Methods Results Conclusion Glucocerebrosidase 1 (GBA1) mutations are associated with reduced survival in Parkinson's disease but their effect on survival in dementia with Lewy bodies (DLB) is unclear.To assess the impact of GBA1 mutations on survival among Ashkenazi Jews with DLB, while controlling for APOE status.One hundred and forty participants from Tel Aviv Medical Center, Israel were genotyped for GBA1 mutations and APOE polymorphisms. Survival rates and follow‐up cognitive screening scores were analyzed.GBA1 mutation carriers had a two‐fold increased risk of death (HR = 1.999), while APOE status did not independently affect survival. In a subset of patients with available clinical data (N = 63), carriers of the APOE ε4 allele showed faster cognitive deterioration, while GBA1 mutation carriers also declined more rapidly albeit not significantly.Understanding the genetic effects on survival and progression is crucial for patient counseling and inclusion in clinical trials. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

The solution and verification of single-digit multiplication problems vary in speed and accuracy. The current study examines whether the number of different digits in a problem accounts for this variance. In Experiment 1, 41 participants solved all 2–9 multiplication problems. In Experiment 2, 43 participants verified these problems. In Experiment 3, 26 participants solved 10 problems that differed in shared-digit network (SDN) size and matched in problem size. In Experiment 4, 24 participants verified these matched sets. Results show faster and more accurate responses to problems that include fewer different digits relative to problems with more different digits, and faster and more accurate responses to problems whose SDN is small relative to problems whose SDN is large. We thus show that the number of different digits in a problem, including the operands and the solution, determines the speed and accuracy of its solution and verification. This parsimonious account also explains why responses to five and tie problems, which include fewer different digits relative to nonfive and nontie problems, are faster and more accurate than responses to other problems. [ABSTRACT FROM AUTHOR]

Background: Vocabulary scores increase until approximately age 65 years and then remain stable or decrease slightly, unlike scores on tests of other cognitive abilities that decline significantly with age. Aims: To review the findings on ageing‐related changes in vocabulary, and to discuss four methodological issues: research design; test type; measurement; and vocabulary ability as a proxy for general intelligence. Main Contribution: A discussion of cross‐sectional and longitudinal research designs shows that cohort membership accounts for some but not all ageing‐related changes in vocabulary, and that drop‐out and test–retest effects do not alter conclusions regarding these changes. Test type affects age trends in vocabulary, and if researchers use only one test, they should choose a multiple‐choice synonym test. While some authors suggest that vocabulary tests do not measure the same underlying ability in younger and older adults, more research of this suggestion is needed. A brief examination of the use of vocabulary ability as a proxy for general intelligence in healthy ageing and for premorbid abilities in dementia indicates that such practice is often questionable. Conclusions: Vocabulary knowledge increases through the mid‐60s regardless of measurement method. However, there is little information on how word knowledge serves other verbal skills in old age, how and when adults learn new words, or how much exposure is necessary for meanings to remain in storage for a lifetime. Research of these issues may require new methodologies, as well as novel theoretical accounts of ageing‐related effects on vocabulary. WHAT THIS PAPER ADDS: What is already known on this subject: Unlike many cognitive abilities that decline with ageing, vocabulary knowledge continues to increase until approximately age 65, and then remains stable or decreases slightly. These findings have been replicated in different research designs and across languages. What this paper adds to existing knowledge: The article presents a summary of findings on changes in vocabulary across adulthood, and a discussion of four key methodological issues: research design, test type, measurement, and the use of vocabulary ability as a proxy for general intelligence. What are the potential or actual clinical implications of this work?: To better understand changes in vocabulary knowledge across adulthood, clinicians must be aware of methodological considerations that affect the field. Such considerations have direct clinical implications regarding the choice of vocabulary tests and their use as a proxy for other abilities in both healthy older adults and in individuals with dementia. [ABSTRACT FROM AUTHOR]

This research examines anthropomorphism by testing the values that people attribute to electronic devices. We ask four main questions: Do people attribute human values to devices; Do devices differ in their value profiles; What underlies the attribution of values to devices; and Do individual and social differences affect these attributions. In Study 1, participants (N = 265) attributed Schwartz's 10 basic human values to devices, reported their personal value priorities, as well as the frequency and difficulty in using each device. In Study 2, participants (N = 231) attributed values to devices, and responses were analyzed by age. Results show that people attribute human values to electronic devices, and that each device has a unique value profile. Anthropomorphizing devices reflects social consensus as to the symbolic meaning of each device, rather than projection of personal values or frequency of device use. Members of social groups share device values and differ from members of other groups. [ABSTRACT FROM AUTHOR]

Objectives This study aimed to examine which verbal fluency task is most useful in assessing adolescents with reading disorders (RD). Method Eighty-three Hebrew-speaking adolescents (ages 12–15), 42 of them with RD, completed semantic and phonemic fluency tasks, and their scores were converted to standardized scores according to population norms. Results Scores on the semantic task were similar in the RD and the control group, unlike scores on the phonemic task, which were significantly lower in the RD group. The RD group demonstrated higher semantic than phonemic scores, unlike the control group whose standardized scores on both tasks were similar. Phonemic but not semantic fluency scores predicted spelling scores within the RD group. Conclusions Adolescents with RD have no difficulty on a semantic fluency task, but perform below expected age-matched levels on the phonemic fluency task. To document this task-difference, practitioners must administer both fluency tasks when assessing RD. [ABSTRACT FROM AUTHOR]

The current study compared the assessment of memory with a translated story recall test and its original published norms and an equivalent local test with local norms. Analyses used data from 232 individuals with memory complaints who underwent neuropsychological evaluation at an outpatient memory clinic. One group of participants completed a translated test (N = 126) and another group completed a local test (N = 106). Additionally, participants completed tasks of word list recall, picture naming, and verbal fluency, all having local norms. The results showed that raw scores on the delayed story recall test, and on all other cognitive tasks, did not differ across groups, and the cross-task correlations were significant and similar in size in both groups. Yet, there was an interaction between group and standardized tests scores, whereby the standardized scores on the translated story recall test were equivalent to population mean, whereas all other scores fell below the mean. Conversion of raw scores to the original norms indicated that the performance of individuals with memory complaints was intact, while conversion of scores on a local test to local norms revealed the expected memory impairment. The findings highlight the importance of using local tests and local norms in the assessment of memory. [ABSTRACT FROM AUTHOR]

Older adults consistently report young subjective age and provide high ratings of their subjective health. The current research examined which social comparisons older adults make when they assess their subjective age and health, as well as the effects of experimentally manipulated social comparisons on these assessments. In Study 1, 146 participants (aged 60 and over) reported to whom they compared themselves when assessing their subjective age or health. In Study 2, 100 participants (aged 60 and over) reported their subjective age and health after receiving feedback that compared them to younger adults or to their peers. Study 1 shows that participants compared themselves primarily to their peer group. Yet, individuals who selected a younger comparison group when assessing subjective age reported a younger subjective age, better self-rated health and more positive expectations regarding ageing relative to those who selected their peers as a comparison group. No equivalent differences emerged in any of the measures when participants were divided by their selection of comparison group after providing their self-rated health ratings. In Study 2, feedback that emphasised the performance of younger people led to reports of younger subjective age relative to feedback that emphasised peer performance, with no equivalent difference for self-rated health. These findings help explain why older adults feel younger and healthier than they actually are. We suggest that older adults use social comparisons as a strategy that protects them from the negative effects of ageing on self-perception. [ABSTRACT FROM AUTHOR]

Previous research has assumed that all types of semantic knowledge are similarly affected by aging. We investigate whether knowledge of vocabulary and math concepts show comparable lifetime change. A sample of 252 participants aged 17–91 completed two multiple-choice tasks that examined knowledge of infrequent word meanings and knowledge of basic math concepts. Up to age 64, vocabulary scores improved, whereas math scores remained stable. After that age, vocabulary scores remained stable, while math scores declined. We suggest that the fact that the learning and use of infrequent vocabulary are incidental, incremental, and contextual contributes to maintenance of word knowledge into old age. In contrast, learning of basic math concepts occurs relatively early in life in an intentional manner, and both learning and use of these concepts involve constrained contexts. Thus, the nature of the acquisition and use of semantic knowledge across the lifespan affects its fate in old age. [ABSTRACT FROM AUTHOR]

Objectives This study examined the longitudinal relationships between subjective age (SA) and future functional status in later life, via depressive symptoms. Additionally, we assessed the role of subjective nearness to death (SNtD) as a potential moderator within these pathways. Methods Older adults (average age 81.14 years at T1) were interviewed once a year for 3 consecutive years (N = 224 at T1, N = 178 at T2, and N = 164 at T3). Participants reported their SA, SNtD, depressive symptoms, and functional status. Additionally, grip strength was employed as an objective measure of functional status. Results Data analysis revealed distinct pathways leading from T1 SA to T3 functional status through T2 depressive symptoms. Moreover, T1 SNtD was found to significantly moderate most of these indirect pathways, so that the mediation model of T1 SA–T2 depressive symptoms–T3 functional status was mostly significant among those who felt closer to death. Discussion The findings contribute to our understanding of the underlying mechanism through which SA predicts long-term functioning sequelae by underscoring the indirect effect of depressive symptoms. They further indicate the importance of gauging the effects of SNtD on these longitudinal relationships. Present results may further contribute to establishing an integrative model for predicting long-term functional outcomes based on older adults' earlier subjective views of aging. [ABSTRACT FROM AUTHOR]

Objectives: The aim of this study was to examine whether the discrepancy between participant and informant estimation of memory decline can predict MCI prognosis.Methods: Analyses involved data from individuals with MCI enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) who filled the Everyday Cognition questionnaire. Participants who underestimated (N = 112) and overestimated (N = 157) their memory decline were compared on memory tasks, brain volume, and cerebrospinal markers, at study entry and after 24 months.Results: Individuals who underestimated their memory decline performed more poorly on memory tests, had smaller hippocampus volume, and greater Alzheimer's disease pathology than did individuals who overestimated their cognitive decline. Longitudinal comparisons demonstrated that individuals who underestimated their decline deteriorated more significantly in memory and in brain measures.Conclusions: Underestimation of memory decline should raise clinicians' suspicion of the existence of AD pathology in individuals with MCI. [ABSTRACT FROM AUTHOR]