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Your search keyword '"Kaushik, Akash K."' showing total 18 results
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18 results on '"Kaushik, Akash K."'

1. Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness

Author

Parida, Pravat Kumar, Marquez-Palencia, Mauricio, Nair, Vidhya, Kaushik, Akash K., Kim, Kangsan, Sudderth, Jessica, Quesada-Diaz, Eduardo, Cajigas, Ambar, Vemireddy, Vamsidhara, Gonzalez-Ericsson, Paula I., Sanders, Melinda E., Mobley, Bret C., Huffman, Kenneth, Sahoo, Sunati, Alluri, Prasanna, Lewis, Cheryl, Peng, Yan, Bachoo, Robert M., Arteaga, Carlos L., Hanker, Ariella B., DeBerardinis, Ralph J., and Malladi, Srinivas

Published
2022
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2. A renal cell carcinoma tumorgraft platform to advance precision medicine

Author

Elias, Roy, Tcheuyap, Vanina T., Kaushik, Akash K., Singla, Nirmish, Gao, Ming, Reig Torras, Oscar, Christie, Alana, Mulgaonkar, Aditi, Woolford, Layton, Stevens, Christina, Kettimuthu, Kavitha Priya, Pavia-Jimenez, Andrea, Boroughs, Lindsey K., Joyce, Allison, Dakanali, Marianna, Notgrass, Hollis, Margulis, Vitaly, Cadeddu, Jeffrey A., Pedrosa, Ivan, Williams, Noelle S., Sun, Xiankai, DeBerardinis, Ralph J., Öz, Orhan K., Zhong, Hua, Seshagiri, Somasekar, Modrusan, Zora, Cantarel, Brandi L., Kapur, Payal, and Brugarolas, James

Published
2021
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3. The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer

Author

Kim, Jiyeon, Lee, Hyun Min, Cai, Feng, Ko, Bookyung, Yang, Chendong, Lieu, Elizabeth L., Muhammad, Nefertiti, Rhyne, Shawn, Li, Kailong, Haloul, Mohamed, Gu, Wen, Faubert, Brandon, Kaushik, Akash K., Cai, Ling, Kasiri, Sahba, Marriam, Ummay, Nham, Kien, Girard, Luc, Wang, Hui, Sun, Xiankai, Kim, James, Minna, John D., Unsal-Kacmaz, Keziban, and DeBerardinis, Ralph J.

Published
2020
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6. In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma

Author

Kaushik, Akash K., primary, Tarangelo, Amy, additional, Boroughs, Lindsey K., additional, Ragavan, Mukundan, additional, Zhang, Yuanyuan, additional, Wu, Cheng-Yang, additional, Li, Xiangyi, additional, Ahumada, Kristen, additional, Chiang, Jui-Chung, additional, Tcheuyap, Vanina T., additional, Saatchi, Faeze, additional, Do, Quyen N., additional, Yong, Cissy, additional, Rosales, Tracy, additional, Stevens, Christina, additional, Rao, Aparna D., additional, Faubert, Brandon, additional, Pachnis, Panayotis, additional, Zacharias, Lauren G., additional, Vu, Hieu, additional, Cai, Feng, additional, Mathews, Thomas P., additional, Genovese, Giannicola, additional, Slusher, Barbara S., additional, Kapur, Payal, additional, Sun, Xiankai, additional, Merritt, Matthew, additional, Brugarolas, James, additional, and DeBerardinis, Ralph J., additional

Published
2022
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7. In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors

Author

Pachnis, Panayotis, primary, Wu, Zheng, additional, Faubert, Brandon, additional, Tasdogan, Alpaslan, additional, Gu, Wen, additional, Shelton, Spencer, additional, Solmonson, Ashley, additional, Rao, Aparna D., additional, Kaushik, Akash K., additional, Rogers, Thomas J., additional, Ubellacker, Jessalyn M., additional, LaVigne, Collette A., additional, Yang, Chendong, additional, Ko, Bookyung, additional, Ramesh, Vijayashree, additional, Sudderth, Jessica, additional, Zacharias, Lauren G., additional, Martin-Sandoval, Misty S., additional, Do, Duyen, additional, Mathews, Thomas P., additional, Zhao, Zhiyu, additional, Mishra, Prashant, additional, Morrison, Sean J., additional, and DeBerardinis, Ralph J., additional

Published
2022
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8. Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis

Author

Dasgupta, Subhamoy, Putluri, Nagireddy, Long, Weiwen, Zhang, Bin, Wang, Jianghua, Kaushik, Akash K., Arnold, James M., Bhowmik, Salil K., Stashi, Erin, Brennan, Christine A., Rajapakshe, Kimal, Coarfa, Cristian, Mitsiades, Nicholas, Ittmann, Michael M., Chinnaiyan, Arul M., Sreekumar, Arun, and O'Malley, Bert W.

Subjects
Development and progression, Research, Patient outcomes, Cancer research, Prostate cancer -- Patient outcomes -- Development and progression, Cancer metastasis -- Research, Oncology, Experimental, Metastasis -- Research, Cancer -- Research
Abstract

Introduction Tumors scavenge various nutrients for carbon and nitrogen sources required for the synthesis of biomolecules to support the growth and replication of their rapidly dividing cells. Nutrient availability plays [...], Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival and supports the anabolic and energetic demands of these rapidly dividing cells. The underlying regulators of the tumor metabolic program are not completely understood; however, these factors have potential as cancer therapy targets. Here, we determined that upregulation of the oncogenic transcriptional coregulator steroid receptor coactivator 2 (SRC-2), also known as NCOA2, drives glutamine-dependent de novo lipogenesis, which supports tumor cell survival and eventual metastasis. SRC-2 was highly elevated in a variety of tumors, especially in prostate cancer, in which SRC-2 was amplified and overexpressed in 37% of the metastatic tumors evaluated. In prostate cancer cells, SRC-2 stimulated reductive carboxylation of a- ketoglutarate to generate citrate via retrograde TCA cycling, promoting lipogenesis and reprogramming of glutamine metabolism. Glutamine-mediated nutrient signaling activated SRC-2 via mTORC1-dependent phosphorylation, which then triggered downstream transcriptional responses by coactivating SREBP-1, which subsequently enhanced lipogenic enzyme expression. Metabolic profiling of human prostate tumors identified a massive increase in the SRC-2-driven metabolic signature in metastatic tumors compared with that seen in localized tumors, further implicating SRC-2 as a prominent metabolic coordinator of cancer metastasis. Moreover, SRC-2 inhibition in murine models severely attenuated the survival, growth, and metastasis of prostate cancer. Together, these results suggest that the SRC-2 pathway has potential as a therapeutic target for prostate cancer.

Published
2015
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9. Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28) Promotes Tumor Progression and Is Elevated in African American Prostate Cancer Patients

Author

Ravindran, Anindita, primary, Krieger, Kimiko L., additional, Kaushik, Akash K., additional, Hovington, Hélène, additional, Mehdi, Sadia, additional, Piyarathna, Danthasinghe Waduge Badrajee, additional, Putluri, Vasanta, additional, Basil, Paul, additional, Rasaily, Uttam, additional, Gu, Franklin, additional, Dang, Truong, additional, Choi, Jong Min, additional, Sonavane, Rajni, additional, Jung, Sung Yun, additional, Wang, Lisha, additional, Mehra, Rohit, additional, Weigel, Nancy L., additional, Putluri, Nagireddy, additional, Rowley, David R., additional, Palapattu, Ganesh S., additional, Guillemette, Chantal, additional, Lacombe, Louis, additional, Lévesque, Éric, additional, and Sreekumar, Arun, additional

Published
2022
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11. Abstract 245: Glutamine fuels the TCA cycle in VHL and FH mutant renal cell carcinoma

Author

Kaushik, Akash K., primary, Yong, Cissy, additional, Ragavan, Mukundan, additional, Stevens, Christina, additional, Woolford, Layton, additional, Rao, Aparna, additional, Faubert, Brandon, additional, Pachnis, Panayotis, additional, Zacharias, Lauren, additional, Vu, Hieu, additional, Merritt, Matthew, additional, Brugarolas, James, additional, and DeBerardinis, Ralph J., additional

Published
2020
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12. The hexosamine biosynthesis pathway is a targetable liability in lung cancers with concurrent KRAS and LKB1 mutations

Author

Kim, Jiyeon, primary, Cai, Feng, additional, Ko, Bookyung, additional, Yang, Chendong, additional, Lee, Hyun Min, additional, Muhammad, Nefertiti, additional, Li, Kailong, additional, Haloul, Mohamed, additional, Gu, Wen, additional, Faubert, Brandon, additional, Kaushik, Akash K., additional, Cai, Ling, additional, Kasiri, Sahba, additional, Marriam, Ummay, additional, Nham, Kien, additional, Girard, Luc, additional, Wang, Hui, additional, Sun, Xiankai, additional, Kim, James, additional, Minna, John D., additional, Unsal-Kacmaz, Keziban, additional, and DeBerardinis, Ralph J., additional

Published
2020
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13. Abstract 1056: Inhibition of hexose monophosphate pathway promotes castration resistant prostate cancer

Author

Kaushik, Akash K., primary, Shojaie, Ali, additional, Panzitt, Katrin, additional, Sonavane, Rajni, additional, Venghatakrishnan, Harene, additional, Manikkam, Mohan, additional, Zaslavsky, Alexander, additional, Putluri, Vasanta, additional, Vasu, Vihas, additional, Zhang, Yiqing, additional, Khan, Ayesha, additional, Lloyd, Stacy, additional, Szafran, Adam, additional, Dasgupta, Subhamoy, additional, Bader, David, additional, Stossi, Fabio, additional, Li, Hangwen, additional, Samanta, Susmita, additional, Cao, Xuhong, additional, Tsouko, Efrosini, additional, Huang, Shixia, additional, Frigo, Daniel, additional, Chan, Lawrence, additional, Edwards, Dean, additional, Kaipparettu, Benny, additional, Mitsiades, Nicholas, additional, Weigel, Nancy, additional, Mancini, Michael, additional, Ittmann, Michael, additional, Chinnaiyan, Arul, additional, Putluri, Nagireddy, additional, Palapattu, Ganesh, additional, Michailidis, George, additional, and Sreekumar, Arun, additional

Published
2016
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14. Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer

Author

Kaushik, Akash K., primary, Shojaie, Ali, additional, Panzitt, Katrin, additional, Sonavane, Rajni, additional, Venghatakrishnan, Harene, additional, Manikkam, Mohan, additional, Zaslavsky, Alexander, additional, Putluri, Vasanta, additional, Vasu, Vihas T., additional, Zhang, Yiqing, additional, Khan, Ayesha S., additional, Lloyd, Stacy, additional, Szafran, Adam T., additional, Dasgupta, Subhamoy, additional, Bader, David A., additional, Stossi, Fabio, additional, Li, Hangwen, additional, Samanta, Susmita, additional, Cao, Xuhong, additional, Tsouko, Efrosini, additional, Huang, Shixia, additional, Frigo, Daniel E., additional, Chan, Lawrence, additional, Edwards, Dean P., additional, Kaipparettu, Benny A., additional, Mitsiades, Nicholas, additional, Weigel, Nancy L., additional, Mancini, Michael, additional, McGuire, Sean E., additional, Mehra, Rohit, additional, Ittmann, Michael M., additional, Chinnaiyan, Arul M., additional, Putluri, Nagireddy, additional, Palapattu, Ganesh S., additional, Michailidis, George, additional, and Sreekumar, Arun, additional

Published
2016
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16. Metabolomic Profiling Identifies Biochemical Pathways Associated with Castration-Resistant Prostate Cancer

Author

Kaushik, Akash K., primary, Vareed, Shaiju K., additional, Basu, Sumanta, additional, Putluri, Vasanta, additional, Putluri, Nagireddy, additional, Panzitt, Katrin, additional, Brennan, Christine A., additional, Chinnaiyan, Arul M., additional, Vergara, Ismael A., additional, Erho, Nicholas, additional, Weigel, Nancy L., additional, Mitsiades, Nicholas, additional, Shojaie, Ali, additional, Palapattu, Ganesh, additional, Michailidis, George, additional, and Sreekumar, Arun, additional

Published
2013
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18. In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma

Author

Akash K. Kaushik, Amy Tarangelo, Lindsey K. Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina T. Tcheuyap, Faeze Saatchi, Quyen N. Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D. Rao, Brandon Faubert, Panayotis Pachnis, Lauren G. Zacharias, Hieu Vu, Feng Cai, Thomas P. Mathews, Giannicola Genovese, Barbara S. Slusher, Payal Kapur, Xiankai Sun, Matthew Merritt, James Brugarolas, Ralph J. DeBerardinis, Kaushik, Akash K [0000-0002-8200-2370], Tarangelo, Amy [0000-0002-0571-3582], Ragavan, Mukundan [0000-0001-8678-4229], Li, Xiangyi [0000-0002-6157-8047], Chiang, Jui-Chung [0000-0001-9979-8347], Tcheuyap, Vanina T [0000-0002-6817-9241], Saatchi, Faeze [0000-0001-9151-7133], Do, Quyen N [0000-0001-9511-7866], Yong, Cissy [0000-0002-8697-1494], Rosales, Tracy [0000-0002-7285-2427], Rao, Aparna D [0000-0002-6394-0011], Faubert, Brandon [0000-0002-2886-886X], Pachnis, Panayotis [0000-0002-3019-7874], Mathews, Thomas P [0000-0002-9355-8243], Slusher, Barbara S [0000-0001-9814-4157], Sun, Xiankai [0000-0002-5140-6110], Merritt, Matthew [0000-0003-4617-9651], Brugarolas, James [0000-0002-8575-499X], DeBerardinis, Ralph J [0000-0002-2705-7432], and Apollo - University of Cambridge Repository

Subjects
Mice, Multidisciplinary, Glutaminase, Glutamine, Humans, Animals, Carcinoma, Renal Cell, Kidney Neoplasms, Isocitrate Dehydrogenase
Abstract

Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts (tumorgrafts) from diverse subtypes of RCC. Tumorgrafts from VHL -mutant clear cell RCC (ccRCC) retained metabolic features of human ccRCC and engaged in oxidative and reductive glutamine metabolism. Genetic silencing of isocitrate dehydrogenase-1 or isocitrate dehydrogenase-2 impaired reductive labeling of tricarboxylic acid (TCA) cycle intermediates in vivo and suppressed growth of tumors generated from tumorgraft-derived cells. Glutaminase inhibition reduced the contribution of glutamine to the TCA cycle and resulted in modest suppression of tumorgraft growth. Infusions with [amide- 15 N]glutamine revealed persistent amidotransferase activity during glutaminase inhibition, and blocking these activities with the amidotransferase inhibitor JHU-083 also reduced tumor growth in both immunocompromised and immunocompetent mice. We conclude that ccRCC tumorgrafts catabolize glutamine via multiple pathways, perhaps explaining why it has been challenging to achieve therapeutic responses in patients by inhibiting glutaminase.

Published
2022

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