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A novel series of transition metal complexes have been synthesized from the reaction of 5-((3-(methylthio)-5-(pyridin-4-yl)-4 H -1,2,4-triazol-4-ylamino)methyl)quinolin-8-ol with transition metal salts. The structures of these compounds have been elucidated by elemental and spectral analysis. Furthermore, compounds were screened for in vitro antimicrobial activity against the representative panel of two Gram-positive and two Gram-negative bacteria and two strains of fungus. The various compounds show potent inhibitory action against test organisms.

New ligands 5-((4-(3-(pyridine-4-yl)-7H-[1,2,4]triazolo[3,4-b] [1, 3,4]thiadiazine-6-yl)phenylamino)methyl)quinolin-8-ol (L1) and 5-((3-(pyridine-4-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-6- ylamino)methyl)quinolin-8-ol (L2) have been synthesized. The obtained ligands were characterized by 1H NMR, 13C NMR, and IR spectroscopic techniques, and reacted with transition metal salts to afford metal containing heterochelates. The structures of the synthesized heterochelates were characterized using elemental analyses, infrared spectra, electronic spectra, magnetic measurements, FAB mass spectrum, and thermo gravimetric analyses. The kinetic parameters, such as order of reaction (n) and the energy of activation (Ea), are reported using the Freeman–Carroll method. Ligands and heterochelates were also screened for their in vitro antibacterial activity.

A new ligand, 5-{[5-(pyridine-4-yl)-1,3,4-oxadiazole-2-ylthio]methyl}quinoline-8-ol (K), was synthesized by base-catalysed reaction of 5-chloromethyl-8-hydroxy quinoline (CMQ) and 5-(pyridine-4-yl)-1,3,4-oxadiazole-2-thiol. The obtained ligand K was characterized by 1H NMR, 13C NMR and IR spectroscopic techniques and reacted with transition metal salts to afford metal-containing heterochelates. The structures of the synthesized heterochelates were characterized using elemental analyses, infrared spectra, electronic spectra, magnetic measurements, FAB mass spectrum and thermogravimetric analyses. The kinetic parameters such as order of reaction (n) and the energy of activation (Ea) are reported using the Freeman–Carroll method. The pre-exponential factor (A), the activation entropy (ΔS#), the activation enthalpy (ΔH#) and the free energy of activation (ΔG#) were calculated. Heterochelates were also screened for their in vitro antibacterial activity against a range of Gram-positive (Bacillus substilis, Staphylococcus aureus) and Gram-negative (Escherichia coli, Serratiamarcescens) organisms. Copyright © 2010 John Wiley & Sons, Ltd.