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742 results on '"Kaur, Charanjit"'

37. Immersing into the lives of Punjabi women: Personal narratives on alcohol consumption.

Author

Kaur, Charanjit, Kaur, Ashwinder, and Kaur, Parveenpal

Subjects
*SOCIAL norms, *ALCOHOL drinking, *DOUBLE standard, *EVIDENCE gaps, *MINORITY women
Abstract

Historically, alcohol has been seen as a male-dominated activity, leading to societal expectations for women to avoid excessive drinking due to their role in reproduction. This creates a repressive double standard, controlled through societal norms and family influence. Focusing on Punjabi Sikh women in Malaysia, this study is vital as it uncovers their experiences with alcohol, filling a gap in research on ethnic minority women. Through interviews, it explores diverse interpretations of religious and cultural norms, indicating that many women feel a sense of freedom and exhibit no reservations in their alcohol consumption, challenging conventional expectations. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Targeting Peroxisome Proliferator-Activated Receptor-β/δ, Reactive Oxygen Species and Redox Signaling with Phytocompounds for Cancer Therapy.

Author

Kaur, Charanjit, Sahu, Sanjeev Kumar, Bansal, Keshav, DeLiberto, Lindsay K., Zhang, Jie, Tewari, Devesh, and Bishayee, Anupam

Subjects
*REACTIVE oxygen species, *TREATMENT effectiveness, *CANCER cells, *OXIDATIVE stress, *CARCINOGENESIS
Abstract

Significance: Peroxisome proliferator-activated receptors (PPARs) have a moderately preserved amino-terminal domain, an extremely preserved DNA-binding domain, an integral hinge region, and a distinct ligand-binding domain that are frequently encountered with the other nuclear receptors. PPAR-β/δ is among the three nuclear receptor superfamily members in the PPAR group. Recent Advances: Emerging studies provide an insight on natural compounds that have gained increasing attention as potential anticancer agents due to their ability to target multiple pathways involved in cancer development and progression. Critical Issues: Modulation of PPAR-β/δ activity has been suggested as a potential therapeutic strategy for cancer management. This review focuses on the ability of bioactive phytocompounds to impact reactive oxygen species (ROS) and redox signaling by targeting PPAR-β/δ for cancer therapy. The rise of ROS in cancer cells may play an important part in the initiation and progression of cancer. However, excessive levels of ROS stress can also be toxic to the cells and cancer cells with increased oxidative stress are likely to be more vulnerable to damage by further ROS insults induced by exogenous agents, such as phytocompounds and therapeutic agents. Therefore, redox modulation is a way to selectively kill cancer cells without causing significant toxicity to normal cells. However, use of antioxidants together with cancer drugs may risk the effect of treatment as both act through opposite mechanisms. Future Directions: It is advisable to employ more thorough and detailed methodologies to undertake mechanistic explorations of numerous phytocompounds. Moreover, conducting additional clinical studies is recommended to establish optimal dosages, efficacy, and the impact of different phytochemicals on PPAR-β/δ. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Cover Image

Author

Lim, Rayne R., primary, Mahaling, Binapani, additional, Tan, Alison, additional, Mehta, Milan, additional, Kaur, Charanjit, additional, Hunziker, Walter, additional, Kim, Judy E., additional, Barathi, Veluchamy A., additional, Ghosh, Arkasubhra, additional, and Chaurasia, Shyam S., additional

Published
2024
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46. Study of baryon number and lepton flavour violation in the new minimal supersymmetric SO(10)GUT

Author

Kaur, Charanjit

Subjects
High Energy Physics - Phenomenology
Abstract

We study the so-called new minimal supersymmetric SO(10) GUT(NMSGUT) where explicit spontaneous symmetry breaking allows determination of superheavy spectrum and thus threshold corrections to the effective MSSM couplings. This provides a generic mechanism to resolve the long standing super fast proton decay in Susy GUTs. We estimate lepton flavor violation associated with realistic charged fermion and (Type I seesaw) neutrino fit and show compatibility with baryon number and lepton flavour violation limits. We improve NMSGUT fits by including important loop corrections to sparticle spectra. Our fits use 5 GUT compatible soft supersymmetry breaking parameters of the Supergravity with Non-Universal Higgs Masses(SUGRY-NUHM) type. We calculate the full two loop NMSGUT gauge-Yukawa beta functions to study feasibility of the NUHM parameters via strong renormalization of SO(10) Higgs soft masses. Focus on MSSM Higgs allows formulation of a "Yukawonification" strategy for gauged flavour unification., Comment: Ph.D. Thesis, 196 pages and 11 figures

Published
2015

50. Mogul in a Baby

Author

Kandachar, Pranav S, primary, Varughese, Nithil A, additional, Kaur, Charanjit, additional, Al Farqani, Abdulla MS, additional, and Al Lawati, Ala, additional

Published
2023
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