57,855 results on '"Kaul A"'
Search Results
2. From Attention to Activation: Unravelling the Enigmas of Large Language Models
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Kaul, Prannay, Ma, Chengcheng, Elezi, Ismail, and Deng, Jiankang
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Computer Science - Computation and Language - Abstract
We study two strange phenomena in auto-regressive Transformers: (1) the dominance of the first token in attention heads; (2) the occurrence of large outlier activations in the hidden states. We find that popular large language models, such as Llama attend maximally to the first token in 98% of attention heads, a behaviour we attribute to the softmax function. To mitigate this issue, we propose a reformulation of softmax to softmax-1. Furthermore, we identify adaptive optimisers, e.g. Adam, as the primary contributor to the large outlier activations and introduce OrthoAdam, a novel optimiser that utilises orthogonal matrices to transform gradients, to address this issue. Finally, not only do our methods prevent these phenomena from occurring, but additionally, they enable Transformers to sustain their performance when quantised using basic algorithms, something that standard methods are unable to do. In summary, our methods reduce the attention proportion on the first token from 65% to 3.3%, the activation kurtosis in the hidden states from 1657 to 3.1, and perplexity penalty under 4-bit weight quantisation from 3565 to 0.3., Comment: 10 pages
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- 2024
3. HpEIS: Learning Hand Pose Embeddings for Multimedia Interactive Systems
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Xu, Songpei, Ge, Xuri, Kaul, Chaitanya, and Murray-Smith, Roderick
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Human-Computer Interaction - Abstract
We present a novel Hand-pose Embedding Interactive System (HpEIS) as a virtual sensor, which maps users' flexible hand poses to a two-dimensional visual space using a Variational Autoencoder (VAE) trained on a variety of hand poses. HpEIS enables visually interpretable and guidable support for user explorations in multimedia collections, using only a camera as an external hand pose acquisition device. We identify general usability issues associated with system stability and smoothing requirements through pilot experiments with expert and inexperienced users. We then design stability and smoothing improvements, including hand-pose data augmentation, an anti-jitter regularisation term added to loss function, stabilising post-processing for movement turning points and smoothing post-processing based on One Euro Filters. In target selection experiments (n=12), we evaluate HpEIS by measures of task completion time and the final distance to target points, with and without the gesture guidance window condition. Experimental responses indicate that HpEIS provides users with a learnable, flexible, stable and smooth mid-air hand movement interaction experience., Comment: 6 pages, 8 figures, 3 tables
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- 2024
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4. Upper limb surface electromyography -- geometry, spectral characteristics, temporal evolution, and demographic confounds
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Gowda, Harshavardhana T., Kaul, Neha, Carrasco, Carlos, Battraw, Marcus A., Amer, Safa, Kotwal, Saniya, Lam, Selena, McNaughton, Zachary, Rahimi, Ferdous, Shehabi, Sana, Schofield, Jonathon S., and Miller, Lee M.
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Electrical Engineering and Systems Science - Signal Processing - Abstract
Brain-body-computer interfaces aim to provide a fluid and natural way for humans to interact with technology. Among noninvasive interfaces, surface electromyogram (sEMG) signals have shown particular utility. However, much remains unknown about how sEMG is affected by various physiological and anatomical factors and how these confounds might affect gesture decoding across individuals or groups. In this article, we show that sEMG signals evince non-Euclidean graph data structure that is defined by a set of orthogonal axes and explain the signal distribution shift across individuals. We provide a dataset of upper limb sEMG signals and physiological measures of 91 adults as they perform 10 different hand gestures. Participants were selected to be representative of various age groups (18to 92 years) and BMI (healthy, overweight, and obese). Additional anatomical or physiological measures that might impact sEMG signals were also collected, such as skin hydration and elasticity. The article describes the inherent structure of sEMG data and provides methods to construct differentiable signal features that can be used with machine learning algorithms that use backpropagation. We then analyze how those parameters correlate with various physiological measures to probe if they can induce bias against (or towards) certain population groups. We find that higher frequencies in sEMG, although comprising less power than lower ones, provide better gesture decoding and show less bias with regard to demographic, circumstantial, and physiological confounds (such as age, skin hydration, and skin elasticity)., Comment: 24 pages
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- 2024
5. Counting List Colorings of Unlabeled Graphs
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Kaul, Hemanshu and Mudrock, Jeffrey A.
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Mathematics - Combinatorics ,20B25, 05C15, 05C30, 05A99 - Abstract
The classic enumerative functions for counting colorings of a graph $G$, such as the chromatic polynomial $P(G,k)$, do so under the assumption that the given graph is labeled. In 1985, Hanlon defined and studied the chromatic polynomial for an unlabeled graph $\mathcal{G}$, $P(\mathcal{G}, k)$. Determining $P(\mathcal{G}, k)$ amounts to counting colorings under the action of automorphisms of $\mathcal{G}$. In this paper, we consider the problem of counting list colorings of unlabeled graphs. List coloring of graphs is a widely studied generalization of classic coloring that was introduced by Vizing and by Erd\H{o}s, Rubin, and Taylor in the 1970s. In 1990, Kostochka and Sidorenko introduced the list color function $P_\ell(G,k)$ which is the guaranteed number of list colorings of a labeled graph $G$ over all $k$-list assignments of $G$. In this paper, we extend Hanlon's definition to the list context and define the unlabeled list color function, $P_\ell(\mathcal{G}, k)$, of an unlabeled graph $\mathcal{G}$. In this context, we pursue a fundamental question whose analogues have driven much of the research on counting list colorings and its generalizations: For a given unlabeled graph $\mathcal{G}$, does $P_\ell(\mathcal{G}, k) = P(\mathcal{G}, k)$ when $k$ is large enough? We show the answer to this question is yes for a large class of unlabeled graphs that include point-determining graphs (also known as irreducible graphs and as mating graphs)., Comment: 14 pages
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- 2024
6. 1 year follow Up results of 'ARTIM HF TRIAL' (angiotensin receptor neprilysin inhibitor effect on TEI index & left ventricular mass in heart failure)
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Rajendra Kumar Gokhroo, Kaul Anushri, M.T. Tarik, C. Kailash, N. Rajesh, K. Ashish, G. Manish, and C. Subhash
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LVMASS ,TEI INDEX ,ARNI ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Sacubitril/Valsartan (ARNI) has now class 1 recommendation for treatment of heart failure with reduced ejection fraction (HFrEF). It has been shown to reduce cardiovascular morbidity & mortality in Heart failure with reduced ejection fraction (HFrEF) and significant improvement in all echocardiographic parameters besides TEI index. Tei index is a marker of inflammation, myocardial cell metabolism and its contractile function has not been evaluated as a distinctive entity so we took up this study to evaluate the effects of ARNI on the LV functions using two dimensional (2D)ECHO parameters in Indian population and to assess TEI index for myocardial function. Methods: 256 patients with class II, III or IV HF and EF
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- 2021
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7. Factors Associated with Usage of Oral-PrEP among Female Sex Workers in Nairobi, Kenya, Assessed by Self-Report and a Point-of-Care Urine Tenofovir Immunoassay.
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Shah, Pooja, Spinelli, Matthew, Irungu, Erastus, Kabuti, Rhoda, Ngurukiri, Pauline, Babu, Hellen, Kungu, Mary, Champions, The, Nyabuto, Chrispo, Mahero, Anne, Devries, Karen, Kyegombe, Nambusi, Medley, Graham, Gafos, Mitzy, Seeley, Janet, Weiss, Helen, Kaul, Rupert, Gandhi, Monica, Beattie, Tara, and Kimani, Joshua
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Adolescent girls and young women ,Female sex workers ,HIV prevention ,Hierarchical modelling ,Kenya ,PrEP ,Humans ,Female ,Sex Workers ,Kenya ,Pre-Exposure Prophylaxis ,Adult ,HIV Infections ,Tenofovir ,Self Report ,Anti-HIV Agents ,Medication Adherence ,Young Adult ,Adolescent ,Point-of-Care Systems ,Administration ,Oral ,Point-of-Care Testing ,Cross-Sectional Studies ,Social Stigma - Abstract
Pre-exposure prophylaxis (PrEP) is highly effective at reducing HIV acquisition. We aimed to estimate usage of oral-PrEP, and factors associated with adherence among female sex workers (FSWs) in Nairobi, Kenya, using a novel point-of-care urine tenofovir lateral flow assay (LFA). The Maisha Fiti study randomly selected FSWs from Sex Worker Outreach Program clinics in Nairobi. Data were collected from 1003 FSWs from June-October 2019, including surveys on self-reported oral-PrEP adherence. Adherence was also measured using the LFA for HIV-negative FSWs currently taking oral-PrEP. Informed by a social-ecological theoretical framework, we used hierarchical multivariable logistic regression models to estimate associations between individual, interpersonal/community, and structural/institutional-level factors and either self-reported or LFA-assessed adherence. Overall, 746 HIV-negative FSWs aged 18-40 participated in the study, of whom 180 (24.1%) self-reported currently taking oral-PrEP. Of these, 56 (31.1%) were adherent to oral-PrEP as measured by LFA. In the multivariable analyses, associations with currently taking oral-PrEP included having completed secondary education, high alcohol/substance use, feeling empowered to use PrEP, current intimate partner, no recent intimate partner violence, having support from sex worker organisations, experiencing sex work-related stigma, and seeking healthcare services despite stigma. Associations with oral-PrEP LFA-measured adherence measured included having only primary education, experience of childhood emotional violence, belonging to a higher wealth tertile, and being nulliparous. Oral-PrEP adherence, measured by self-report or objectively, is low among FSWs in Nairobi. Programs to improve oral-PrEP usage among FSWs should work to mitigate social and structural barriers and involve collaboration between FSWs, healthcare providers and policymakers.
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- 2024
8. Single-Machine Scheduling to Minimize the Number of Tardy Jobs with Release Dates
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Kaul, Matthias, Mnich, Matthias, and Molter, Hendrik
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Computer Science - Data Structures and Algorithms ,Computer Science - Discrete Mathematics - Abstract
We study the fundamental scheduling problem $1\mid r_j\mid\sum w_j U_j$: schedule a set of $n$ jobs with weights, processing times, release dates, and due dates on a single machine, such that each job starts after its release date and we maximize the weighted number of jobs that complete execution before their due date. Problem $1\mid r_j\mid\sum w_j U_j$ generalizes both Knapsack and Partition, and the simplified setting without release dates was studied by Hermelin et al. [Annals of Operations Research, 2021] from a parameterized complexity viewpoint. Our main contribution is a thorough complexity analysis of $1\mid r_j\mid\sum w_j U_j$ in terms of four key problem parameters: the number $p_\#$ of processing times, the number $w_\#$ of weights, the number $d_\#$ of due dates, and the number $r_\#$ of release dates of the jobs. $1\mid r_j\mid\sum w_j U_j$ is known to be weakly para-NP-hard even if $w_\#+d_\#+r_\#$ is constant, and Heeger and Hermelin [ESA, 2024] recently showed (weak) W[1]-hardness parameterized by $p_\#$ or $w_\#$ even if $r_\#$ is constant. Algorithmically, we show that $1\mid r_j\mid\sum w_j U_j$ is fixed-parameter tractable parameterized by $p_\#$ combined with any two of the remaining three parameters $w_\#$, $d_\#$, and $r_\#$. We further provide pseudo-polynomial XP-time algorithms for parameter $r_\#$ and $d_\#$. To complement these algorithms, we show that $1\mid r_j\mid\sum w_j U_j$ is (strongly) W[1]-hard when parameterized by $d_\#+r_\#$ even if $w_\#$ is constant. Our results provide a nearly complete picture of the complexity of $1\mid r_j\mid\sum w_j U_j$ for $p_\#$, $w_\#$, $d_\#$, and $r_\#$ as parameters, and extend those of Hermelin et al. [Annals of Operations Research, 2021] for the problem $1\mid\mid\sum w_j U_j$ without release dates.
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- 2024
9. On strongly and robustly critical graphs
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Bernshteyn, Anton, Kaul, Hemanshu, Mudrock, Jeffrey A., and Sharma, Gunjan
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Mathematics - Combinatorics - Abstract
In extremal combinatorics, it is common to focus on structures that are minimal with respect to a certain property. In particular, critical and list-critical graphs occupy a prominent place in graph coloring theory. Stiebitz, Tuza, and Voigt introduced strongly critical graphs, i.e., graphs that are $k$-critical yet $L$-colorable with respect to every non-constant assignment $L$ of lists of size $k-1$. Here we strengthen this notion and extend it to the framework of DP-coloring (or correspondence coloring) by defining robustly $k$-critical graphs as those that are not $(k-1)$-DP-colorable, but only due to the fact that $\chi(G) = k$. We then seek general methods for constructing robustly critical graphs. Our main result is that if $G$ is a critical graph (with respect to ordinary coloring), then the join of $G$ with a sufficiently large clique is robustly critical; this is new even for strong criticality., Comment: 15 pages, 2 figures
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- 2024
10. AI-Enabled sensor fusion of time of flight imaging and mmwave for concealed metal detection
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Kaul, Chaitanya, Mitchell, Kevin J., Kassem, Khaled, Tragakis, Athanasios, Kapitany, Valentin, Starshynov, Ilya, Villa, Federica, Murray-Smith, Roderick, and Faccio, Daniele
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Electrical Engineering and Systems Science - Image and Video Processing - Abstract
In the field of detection and ranging, multiple complementary sensing modalities may be used to enrich the information obtained from a dynamic scene. One application of this sensor fusion is in public security and surveillance, whose efficacy and privacy protection measures must be continually evaluated. We present a novel deployment of sensor fusion for the discrete detection of concealed metal objects on persons whilst preserving their privacy. This is achieved by coupling off-the-shelf mmWave radar and depth camera technology with a novel neural network architecture that processes the radar signals using convolutional Long Short-term Memory (LSTM) blocks and the depth signal, using convolutional operations. The combined latent features are then magnified using a deep feature magnification to learn cross-modality dependencies in the data. We further propose a decoder, based on the feature extraction and embedding block, to learn an efficient upsampling of the latent space to learn the location of the concealed object in the spatial domain through radar feature guidance. We demonstrate the detection of presence and inference of 3D location of concealed metal objects with an accuracy of up to 95%, using a technique that is robust to multiple persons. This work provides a demonstration of the potential for cost effective and portable sensor fusion, with strong opportunities for further development.
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- 2024
11. Meta-Analysis with Untrusted Data
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Kaul, Shiva and Gordon, Geoffrey J.
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Statistics - Machine Learning ,Computer Science - Machine Learning ,Statistics - Methodology - Abstract
[See paper for full abstract] Meta-analysis is a crucial tool for answering scientific questions. It is usually conducted on a relatively small amount of ``trusted'' data -- ideally from randomized, controlled trials -- which allow causal effects to be reliably estimated with minimal assumptions. We show how to answer causal questions much more precisely by making two changes. First, we incorporate untrusted data drawn from large observational databases, related scientific literature and practical experience -- without sacrificing rigor or introducing strong assumptions. Second, we train richer models capable of handling heterogeneous trials, addressing a long-standing challenge in meta-analysis. Our approach is based on conformal prediction, which fundamentally produces rigorous prediction intervals, but doesn't handle indirect observations: in meta-analysis, we observe only noisy effects due to the limited number of participants in each trial. To handle noise, we develop a simple, efficient version of fully-conformal kernel ridge regression, based on a novel condition called idiocentricity. We introduce noise-correcting terms in the residuals and analyze their interaction with a ``variance shaving'' technique. In multiple experiments on healthcare datasets, our algorithms deliver tighter, sounder intervals than traditional ones. This paper charts a new course for meta-analysis and evidence-based medicine, where heterogeneity and untrusted data are embraced for more nuanced and precise predictions., Comment: Full-length version of conference submission
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- 2024
12. First-order N\'eel-VBS transition in $S=3/2$ antiferromagnets
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Zhang, Fan, Guo, Wenan, and Kaul, Ribhu K.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Statistical Mechanics - Abstract
We study the transition between N\'eel and columnar valence-bond solid ordering in two-dimensional $S=3/2$ square lattice quantum antiferromagnets with SO(3) symmetry. According to the deconfined criticality scenario, this transition can be direct and continuous like the well-studied $S=1/2$ case. To study the global phase diagram, we work with four multi-spin couplings with full rotational symmetry, that are free of the sign-problem of quantum Monte Carlo. Exploring the phase diagram with quantum Monte Carlo simulations, we find that the phase transition between N\'eel and valence-bond solid is strongly first-order in the parts of the phase diagram that we have accessed., Comment: 11 pages, 16 figures
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- 2024
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13. Semantic Graph Consistency: Going Beyond Patches for Regularizing Self-Supervised Vision Transformers
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Devaguptapu, Chaitanya, Aithal, Sumukh, Ramasubramanian, Shrinivas, Yamada, Moyuru, and Kaul, Manohar
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Self-supervised learning (SSL) with vision transformers (ViTs) has proven effective for representation learning as demonstrated by the impressive performance on various downstream tasks. Despite these successes, existing ViT-based SSL architectures do not fully exploit the ViT backbone, particularly the patch tokens of the ViT. In this paper, we introduce a novel Semantic Graph Consistency (SGC) module to regularize ViT-based SSL methods and leverage patch tokens effectively. We reconceptualize images as graphs, with image patches as nodes and infuse relational inductive biases by explicit message passing using Graph Neural Networks into the SSL framework. Our SGC loss acts as a regularizer, leveraging the underexploited patch tokens of ViTs to construct a graph and enforcing consistency between graph features across multiple views of an image. Extensive experiments on various datasets including ImageNet, RESISC and Food-101 show that our approach significantly improves the quality of learned representations, resulting in a 5-10\% increase in performance when limited labeled data is used for linear evaluation. These experiments coupled with a comprehensive set of ablations demonstrate the promise of our approach in various settings.
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- 2024
14. Is One GPU Enough? Pushing Image Generation at Higher-Resolutions with Foundation Models
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Tragakis, Athanasios, Aversa, Marco, Kaul, Chaitanya, Murray-Smith, Roderick, and Faccio, Daniele
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence - Abstract
In this work, we introduce Pixelsmith, a zero-shot text-to-image generative framework to sample images at higher resolutions with a single GPU. We are the first to show that it is possible to scale the output of a pre-trained diffusion model by a factor of 1000, opening the road for gigapixel image generation at no additional cost. Our cascading method uses the image generated at the lowest resolution as a baseline to sample at higher resolutions. For the guidance, we introduce the Slider, a tunable mechanism that fuses the overall structure contained in the first-generated image with enhanced fine details. At each inference step, we denoise patches rather than the entire latent space, minimizing memory demands such that a single GPU can handle the process, regardless of the image's resolution. Our experimental results show that Pixelsmith not only achieves higher quality and diversity compared to existing techniques, but also reduces sampling time and artifacts. The code for our work is available at https://github.com/Thanos-DB/Pixelsmith.
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- 2024
15. HOLMES: Hyper-Relational Knowledge Graphs for Multi-hop Question Answering using LLMs
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Panda, Pranoy, Agarwal, Ankush, Devaguptapu, Chaitanya, Kaul, Manohar, and P, Prathosh A
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Computer Science - Computation and Language - Abstract
Given unstructured text, Large Language Models (LLMs) are adept at answering simple (single-hop) questions. However, as the complexity of the questions increase, the performance of LLMs degrade. We believe this is due to the overhead associated with understanding the complex question followed by filtering and aggregating unstructured information in the raw text. Recent methods try to reduce this burden by integrating structured knowledge triples into the raw text, aiming to provide a structured overview that simplifies information processing. However, this simplistic approach is query-agnostic and the extracted facts are ambiguous as they lack context. To address these drawbacks and to enable LLMs to answer complex (multi-hop) questions with ease, we propose to use a knowledge graph (KG) that is context-aware and is distilled to contain query-relevant information. The use of our compressed distilled KG as input to the LLM results in our method utilizing up to $67\%$ fewer tokens to represent the query relevant information present in the supporting documents, compared to the state-of-the-art (SoTA) method. Our experiments show consistent improvements over the SoTA across several metrics (EM, F1, BERTScore, and Human Eval) on two popular benchmark datasets (HotpotQA and MuSiQue)., Comment: Accepted at ACL 2024 in the main track
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- 2024
16. Transverse Field $\gamma$-Matrix Spin Chains
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Siew, Rui Xian, Chandrasekharan, Shailesh, and Kaul, Ribhu K.
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Condensed Matter - Strongly Correlated Electrons - Abstract
We introduce a simple lattice spin model that is written in terms of the well-known four-dimensional $\gamma$-matrix representation of the Clifford algebra. The local spins with a four-dimensional Hilbert space transform in a spinorial $(1/2,0) \oplus (0,1/2)$ representation of $SO(4)$, a symmetry of our model. When studied on a chain, and as a function of a transverse field tuning parameter, our model undergoes a quantum phase transition from a valence bond solid phase to a critical phase that is described by an $SU(2)_1$ WZW field theory., Comment: 12 pages, 9 figures; added references for section 2, corrected a typo in appendix D
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- 2024
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17. Green Human Resource Management: An Empirical Study of India
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Arora Mamta and Kaul Arpita
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environment ,green hrm ,questionnaire ,Environmental sciences ,GE1-350 - Abstract
Purpose: The broad over-arching goals of this work were to study the existing constituents of green human resource management (HRM), to understand the green HRM practices being followed by different companies in India (belonging to certain sectors) and to compare the different sectors in terms of adoption of green HRM. Methodology: A questionnaire was meticulously prepared by the authors to collect the data for this study and was sent to various Indian companies belonging to four sectors: IT/IT services, banking/finance, consultancy and engineering/technology. The questionnaire included a carefully selected collection of questions to gain rich insights into different aspects of green HRM implementation. Findings: most of the companies included in this study are following green HRM (though to varying extents). Green recruitment, green training and development & green safety and health management are the most prominent green HRM functions while green performance appraisal is the least popular green HRM function among these organizations. The IT/IT services sector is most actively using green HRM practices while the banking/finance sector is the most reluctant to adopt green HRM. Practical Implications: a rigorous structure for companies to implement green HRM is provided.
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- 2020
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18. Vaginal fungi are associated with treatment-induced shifts in the vaginal microbiota and with a distinct genital immune profile.
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Armstrong, Eric, Hemmerling, Anke, Miller, Steve, Huibner, Sanja, Kulikova, Maria, Liu, Rachel, Crawford, Emily, Castañeda, Gloria, Coburn, Bryan, Cohen, Craig, and Kaul, Rupert
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Candida ,fungi ,genital immunology ,inflammation ,vaginal microbiome ,Female ,Humans ,Vagina ,Vaginosis ,Bacterial ,Metronidazole ,Microbiota ,Adult ,Candida albicans ,Lactobacillus crispatus ,Interleukin-17 ,Young Adult ,Fungi ,Lactobacillus ,Cytokines ,Probiotics ,Bacteria - Abstract
Vaginal colonization by fungi may elicit genital inflammation and enhance the risk of adverse reproductive health outcomes, such as HIV acquisition. Cross-sectional studies have linked fungi with an absence of bacterial vaginosis (BV), but it is unclear whether shifts in vaginal bacteria alter the abundance of vaginal fungi. Vaginal swabs collected following topical metronidazole treatment for BV during the phase 2b, placebo-controlled trial of LACTIN-V, a Lactobacillus crispatus-based live biotherapeutic, were assayed with semi-quantitative PCR for the relative quantitation of fungi and key bacterial species and multiplex immunoassay for immune factors. Vaginal fungi increased immediately following metronidazole treatment for BV (adjusted P = 0.0006), with most of this increase attributable to Candida albicans. Vaginal fungi were independently linked to elevated levels of the proinflammatory cytokine interleukin (IL) 17A, although this association did not remain significant after correcting for multiple comparisons. Fungal relative abundance by semi-quantitative PCR returned to baseline levels within 1 month of metronidazole treatment and was not affected by LACTIN-V or placebo administration. Fungal abundance was positively associated with Lactobacillus species, negatively associated with BV-associated bacteria, and positively associated with a variety of proinflammatory cytokines and chemokines, including IL-17A, during and after study product administration. Antibiotic treatment for BV resulted in a transient expanded abundance of vaginal fungi in a subset of women which was unaffected by subsequent administration of LACTIN-V. Vaginal fungi were positively associated with Lactobacillus species and IL-17A and negatively associated with BV-associated bacteria; these associations were most pronounced in the longer-term outcomes.IMPORTANCEVaginal colonization by fungi can enhance the risk of adverse reproductive health outcomes and HIV acquisition, potentially by eliciting genital mucosal inflammation. We show that standard antibiotic treatment for bacterial vaginosis (BV) results in a transient increase in the absolute abundance of vaginal fungi, most of which was identified as Candida albicans. Vaginal fungi were positively associated with proinflammatory immune factors and negatively associated with BV-associated bacteria. These findings improve our understanding of how shifts in the bacterial composition of the vaginal microbiota may enhance proliferation by proinflammatory vaginal fungi, which may have important implications for risk of adverse reproductive health outcomes among women.
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- 2024
19. House dust metagenome and pulmonary function in a US farming population.
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Lee, Mikyeong, Kaul, Abhishek, Ward, James, Zhu, Qiyun, Richards, Marie, Wang, Ziyue, González, Antonio, Parks, Christine, Beane Freeman, Laura, Umbach, David, Motsinger-Reif, Alison, Knight, Rob, and London, Stephanie
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Metagenome ,Microbiome ,Microbiota ,Respiratory function tests ,Spirometry ,Whole genome sequencing ,Dust ,Humans ,Metagenome ,Female ,Male ,United States ,Microbiota ,Middle Aged ,Lung ,Adult ,Bacteria ,Forced Expiratory Volume ,Agriculture ,Respiratory Function Tests ,Vital Capacity ,Metagenomics - Abstract
BACKGROUND: Chronic exposure to microorganisms inside homes can impact respiratory health. Few studies have used advanced sequencing methods to examine adult respiratory outcomes, especially continuous measures. We aimed to identify metagenomic profiles in house dust related to the quantitative traits of pulmonary function and airway inflammation in adults. Microbial communities, 1264 species (389 genera), in vacuumed bedroom dust from 779 homes in a US cohort were characterized by whole metagenome shotgun sequencing. We examined two overall microbial diversity measures: richness (the number of individual microbial species) and Shannon index (reflecting both richness and relative abundance). To identify specific differentially abundant genera, we applied the Lasso estimator with high-dimensional inference methods, a novel framework for analyzing microbiome data in relation to continuous traits after accounting for all taxa examined together. RESULTS: Pulmonary function measures (forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio) were not associated with overall dust microbial diversity. However, many individual microbial genera were differentially abundant (p-value < 0.05 controlling for all other microbial taxa examined) in relation to FEV1, FVC, or FEV1/FVC. Similarly, fractional exhaled nitric oxide (FeNO), a marker of airway inflammation, was unrelated to overall microbial diversity but associated with differential abundance for many individual genera. Several genera, including Limosilactobacillus, were associated with a pulmonary function measure and FeNO, while others, including Moraxella to FEV1/FVC and Stenotrophomonas to FeNO, were associated with a single trait. CONCLUSIONS: Using state-of-the-art metagenomic sequencing, we identified specific microorganisms in indoor dust related to pulmonary function and airway inflammation. Some were previously associated with respiratory conditions; others were novel, suggesting specific environmental microbial components contribute to various respiratory outcomes. The methods used are applicable to studying microbiome in relation to other continuous outcomes. Video Abstract.
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- 2024
20. Vaginal Lactobacillus crispatus persistence following application of a live biotherapeutic product: colonization phenotypes and genital immune impact.
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Armstrong, Eric, Hemmerling, Anke, Miller, Steve, Huibner, Sanja, Kulikova, Maria, Crawford, Emily, Castañeda, Gloria, Coburn, Bryan, Cohen, Craig, and Kaul, Rupert
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Humans ,Female ,Vaginosis ,Bacterial ,Vagina ,Lactobacillus crispatus ,Adult ,Probiotics ,Administration ,Intravaginal ,Microbiota ,Young Adult ,Phenotype - Abstract
BACKGROUND: Bacterial vaginosis (BV) increases HIV acquisition risk, potentially by eliciting genital inflammation. After BV treatment, the vaginal administration of LACTIN-V, a live biotherapeutic containing the Lactobacillus crispatus strain CTV-05, reduced BV recurrence and vaginal inflammation; however, 3 months after product cessation, CTV-05 colonization was only sustained in 48% of participants. RESULTS: This nested sub-study in 32 participants receiving LACTIN-V finds that 72% (23/32) demonstrate clinically relevant colonization (CTV-05 absolute abundance > 106 CFU/mL) during at least one visit while 28% (9/32) of women demonstrate colonization resistance, even during product administration. Immediately prior to LACTIN-V administration, the colonization-resistant group exhibited elevated vaginal microbiota diversity. During LACTIN-V administration, colonization resistance was associated with elevated vaginal markers of epithelial disruption and reduced chemokines, possibly due to elevated absolute abundance of BV-associated species and reduced L. crispatus. Colonization permissive women were stratified into sustained and transient colonization groups (31% and 41% of participants, respectively) based on CTV-05 colonization after cessation of product administration. These groups also exhibited distinct genital immune profiles during LACTIN-V administration. CONCLUSIONS: The genital immune impact of LACTIN-V may be contingent on the CTV-05 colonization phenotype, which is in turn partially dependent on the success of BV clearance prior to LACTIN-V administration.
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- 2024
21. THRONE: An Object-based Hallucination Benchmark for the Free-form Generations of Large Vision-Language Models
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Kaul, Prannay, Li, Zhizhong, Yang, Hao, Dukler, Yonatan, Swaminathan, Ashwin, Taylor, C. J., and Soatto, Stefano
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Mitigating hallucinations in large vision-language models (LVLMs) remains an open problem. Recent benchmarks do not address hallucinations in open-ended free-form responses, which we term "Type I hallucinations". Instead, they focus on hallucinations responding to very specific question formats -- typically a multiple-choice response regarding a particular object or attribute -- which we term "Type II hallucinations". Additionally, such benchmarks often require external API calls to models which are subject to change. In practice, we observe that a reduction in Type II hallucinations does not lead to a reduction in Type I hallucinations but rather that the two forms of hallucinations are often anti-correlated. To address this, we propose THRONE, a novel object-based automatic framework for quantitatively evaluating Type I hallucinations in LVLM free-form outputs. We use public language models (LMs) to identify hallucinations in LVLM responses and compute informative metrics. By evaluating a large selection of recent LVLMs using public datasets, we show that an improvement in existing metrics do not lead to a reduction in Type I hallucinations, and that established benchmarks for measuring Type I hallucinations are incomplete. Finally, we provide a simple and effective data augmentation method to reduce Type I and Type II hallucinations as a strong baseline., Comment: In CVPR 2024
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- 2024
22. Generative Active Learning for the Search of Small-molecule Protein Binders
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Korablyov, Maksym, Liu, Cheng-Hao, Jain, Moksh, van der Sloot, Almer M., Jolicoeur, Eric, Ruediger, Edward, Nica, Andrei Cristian, Bengio, Emmanuel, Lapchevskyi, Kostiantyn, St-Cyr, Daniel, Schuetz, Doris Alexandra, Butoi, Victor Ion, Rector-Brooks, Jarrid, Blackburn, Simon, Feng, Leo, Nekoei, Hadi, Gottipati, SaiKrishna, Vijayan, Priyesh, Gupta, Prateek, Rampášek, Ladislav, Avancha, Sasikanth, Bacon, Pierre-Luc, Hamilton, William L., Paige, Brooks, Misra, Sanchit, Jastrzebski, Stanislaw Kamil, Kaul, Bharat, Precup, Doina, Hernández-Lobato, José Miguel, Segler, Marwin, Bronstein, Michael, Marinier, Anne, Tyers, Mike, and Bengio, Yoshua
- Subjects
Quantitative Biology - Biomolecules ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Despite substantial progress in machine learning for scientific discovery in recent years, truly de novo design of small molecules which exhibit a property of interest remains a significant challenge. We introduce LambdaZero, a generative active learning approach to search for synthesizable molecules. Powered by deep reinforcement learning, LambdaZero learns to search over the vast space of molecules to discover candidates with a desired property. We apply LambdaZero with molecular docking to design novel small molecules that inhibit the enzyme soluble Epoxide Hydrolase 2 (sEH), while enforcing constraints on synthesizability and drug-likeliness. LambdaZero provides an exponential speedup in terms of the number of calls to the expensive molecular docking oracle, and LambdaZero de novo designed molecules reach docking scores that would otherwise require the virtual screening of a hundred billion molecules. Importantly, LambdaZero discovers novel scaffolds of synthesizable, drug-like inhibitors for sEH. In in vitro experimental validation, a series of ligands from a generated quinazoline-based scaffold were synthesized, and the lead inhibitor N-(4,6-di(pyrrolidin-1-yl)quinazolin-2-yl)-N-methylbenzamide (UM0152893) displayed sub-micromolar enzyme inhibition of sEH.
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- 2024
23. Federated Learning and Differential Privacy Techniques on Multi-hospital Population-scale Electrocardiogram Data
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Agrawal, Vikhyat, Kalmady, Sunil Vasu, Malipeddi, Venkataseetharam Manoj, Manthena, Manisimha Varma, Sun, Weijie, Islam, Saiful, Hindle, Abram, Kaul, Padma, and Greiner, Russell
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Electrical Engineering and Systems Science - Signal Processing ,Computer Science - Cryptography and Security ,Computer Science - Machine Learning - Abstract
This research paper explores ways to apply Federated Learning (FL) and Differential Privacy (DP) techniques to population-scale Electrocardiogram (ECG) data. The study learns a multi-label ECG classification model using FL and DP based on 1,565,849 ECG tracings from 7 hospitals in Alberta, Canada. The FL approach allowed collaborative model training without sharing raw data between hospitals while building robust ECG classification models for diagnosing various cardiac conditions. These accurate ECG classification models can facilitate the diagnoses while preserving patient confidentiality using FL and DP techniques. Our results show that the performance achieved using our implementation of the FL approach is comparable to that of the pooled approach, where the model is trained over the aggregating data from all hospitals. Furthermore, our findings suggest that hospitals with limited ECGs for training can benefit from adopting the FL model compared to single-site training. In addition, this study showcases the trade-off between model performance and data privacy by employing DP during model training. Our code is available at https://github.com/vikhyatt/Hospital-FL-DP., Comment: Accepted for ICMHI 2024
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- 2024
24. GLFNET: Global-Local (frequency) Filter Networks for efficient medical image segmentation
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Tragakis, Athanasios, Liu, Qianying, Kaul, Chaitanya, Roy, Swalpa Kumar, Dai, Hang, Deligianni, Fani, Murray-Smith, Roderick, and Faccio, Daniele
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence - Abstract
We propose a novel transformer-style architecture called Global-Local Filter Network (GLFNet) for medical image segmentation and demonstrate its state-of-the-art performance. We replace the self-attention mechanism with a combination of global-local filter blocks to optimize model efficiency. The global filters extract features from the whole feature map whereas the local filters are being adaptively created as 4x4 patches of the same feature map and add restricted scale information. In particular, the feature extraction takes place in the frequency domain rather than the commonly used spatial (image) domain to facilitate faster computations. The fusion of information from both spatial and frequency spaces creates an efficient model with regards to complexity, required data and performance. We test GLFNet on three benchmark datasets achieving state-of-the-art performance on all of them while being almost twice as efficient in terms of GFLOP operations.
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- 2024
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25. MR Imaging in Covid-19-Associated Invasive Fungal Sinusitis
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Pabbisetti, Divya, Gudipati, Anantaram, Kaul, Subhash, and Nalla, Sahithi
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Sinusitis -- Diagnosis -- Care and treatment ,Magnetic resonance imaging -- Evaluation - Abstract
Background and Aim: We witnessed a sharp peak in the incidence of invasive fungal sinusitis, particularly mucormycosis, in patients with history of coronavirus disease 2019 (COVID-19) infection in India. Rhino-orbito-cerebral mucormycosis (ROCM) is a fulminant rapidly progressive disease. Early diagnosis significantly improves patient survival and outcomes. Hence, neuroimaging plays a very important role. We studied the magnetic resonance (MR) imaging manifestations of invasive fungal sinusitis and established an imaging protocol, which helps in early diagnosis of the disease per se as well as its complications. We evaluated the differences between COVID-19-associated and non-COVID-19-associated ROCM. Materials and Methods: We retrospectively analyzed the MR imaging manifestations of 91 histopathologically proven cases of post-COVID-19-invasive fungal sinusitis. Results: We observed stage I disease limited to sinuses in 25.2%, stage II disease with intraorbital spread in 23%, and stage III disease with intracranial spread in 51.6% of our patients. Dural involvement was the commonest and earliest sign of stage III disease. Direct parenchymal invasion from the adjacent paranasal sinuses was the commonest pattern of cerebral involvement, involving basifrontal lobe (14.2%) followed by anteromedial temporal lobe (5.4%). We observed orbital and intracranial complications including subperiosteal orbital abscess (1%), cavernous sinus involvement (29.6%), angioinvasion (15.3%), perineural spread (9.8%), and osteomyelitis of skull base and craniofacial bones (45%). Contrary to non-COVID-19-associated ROCM, we did not observe any case with superior ophthalmic vein/dural venous sinus thrombosis or basilar artery angioinvasion in our study. Conclusions: In our study, stage III disease was most commonly due to direct parenchymal invasion into frontal and temporal lobes from the adjacent frontal and sphenoid sinuses, respectively. The commonest vascular complications in our study were cavernous sinus involvement followed by angioinvasion into the cavernous ICA leading to watershed infarcts. Keywords: Angioinvasion, invasive fungal sinusitis, perineural spread, rhino-orbito-cerebral mucormycosis (ROCM), Author(s): Divya Pabbisetti (corresponding author) [1]; Anantaram Gudipati [1]; Subhash Kaul [1]; Sahithi Nalla [1] Key Message: This is an observational study about the pattern of disease involvement in COVID-19-associated [...]
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- 2024
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26. Impact of preoperative back pain severity on PROMIS outcomes following minimally invasive lumbar decompression
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Anwar, Fatima N., Roca, Andrea M., Khosla, Ishan, Loya, Alexandra C., Medakkar, Srinath S., Kaul, Aayush, Wolf, Jacob C., Federico, Vincent P., Sayari, Arash J., Lopez, Gregory D., and Singh, Kern
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- 2024
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27. A Novel Approach for Better Career Counselling Utilizing Machine Learning Techniques
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Bandhu, Kailash Chandra, Litoriya, Ratnesh, Khatri, Mihir, Kaul, Milind, and Soni, Prakhar
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- 2024
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28. Seroprotection achieved with standard four-dose schedule of hepatitis B vaccine in people with chronic kidney disease: A real-life data
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Singh, Surender, Mishra, Ajay Kumar, Yachha, Monika, Singh, Thakur Prashant, Katiyar, Harshita, Kaul, Anupma, Dhiman, Radha Krishna, Bhadauria, Dharmendra Singh, and Goel, Amit
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- 2024
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29. Efficient classification of remote sensing images using DF-DNLSTM: a deep feature densenet bidirectional long short term memory model
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Kumari, Monika and Kaul, Ajay
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- 2024
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30. Prediction of the free vibration characteristics of liquid-storage elevated tanks using finite element techniques
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Kaul, Mitresh and Nallasivam, K.
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- 2024
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31. Implantable Devices in Otolaryngology: Pediatric Application of Active Bone Conduction Devices
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Gaffney, Patrick J., Ahmad, Jumah G., Gong, Shaina W., and Kaul, Vivian F.
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- 2024
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32. Improvement of Stress Corrosion Cracking Resistance of Shear Cut 304L Stainless Steel through Laser Shock Peening
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Gupta, R. K., Rai, A. K., Nagpure, D. C., Biswal, R., Ganesh, P., Rai, S. K., Ranganathan, K., Bindra, K. S., and Kaul, R.
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- 2024
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33. Antistress and Antiaging Potentials of Alpha-Lipoic Acid: Insights from Cell Culture–Based Experiments
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Wadhwa, Renu, Hegde, Mangala, Zhang, Huayue, Kaul, Ashish, Wang, Jia, Ishida, Yoshiyuki, Terao, Keiji, Kunnumakkara, Ajaikumar B., and Kaul, Sunil C.
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- 2024
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34. Counting Packings of List-colorings of Graphs
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Kaul, Hemanshu and Mudrock, Jeffrey A.
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Mathematics - Combinatorics ,05C15, 05C30 - Abstract
Given a list assignment for a graph, list packing asks for the existence of multiple pairwise disjoint list colorings of the graph. Several papers have recently appeared that study the existence of such a packing of list colorings. Formally, a proper $L$-packing of a graph $G$ of size $k$ is a set of $k$ pairwise disjoint proper $L$-colorings of $G$ where $L$ is a list assignment of colors to the vertices of $G$. In this paper, we initiate the study of counting such packings of list colorings of a graph. We define $P_\ell^\star(G,q,k)$ as the guaranteed number of proper $L$-packings of $G$ of size $k$ over all list assignments $L$ that assign $q$ colors to each vertex of $G$, and we let $P^\star(G,q,k)$ be its classical coloring counterpart. We let $P_\ell^\star(G,q)= P_\ell^\star(G,q,q)$ so that $P_\ell^\star(G,q)$ is the enumerative function for the previously studied list packing number $\chi_\ell^\star(G)$. Note that the chromatic polynomial of $G$, $P(G,q)$, is $P^\star(G,q,1)$, and the list color function of $G$, $P_\ell(G,q)$, is $P_\ell^\star(G,q,1)$. Inspired by the well-known behavior of the list color function and the chromatic polynomial, we make progress towards the question of whether $P_{\ell}^\star(G,q,k) = P^\star(G,q,k)$ when $q$ is large enough. Our result generalizes the recent theorem of Dong and Zhang (2023), which improved results going back to Donner (1992), about when the list color function equals the chromatic polynomial. Further, we use a polynomial method to generalize bounds on the list packing number, $\chi_\ell^\star(G)$, of sparse graphs to exponential lower bounds (in the number of vertices of $G$) on the corresponding list packing functions, $P_\ell^\star(G,q)$., Comment: 12 pages
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- 2024
35. Phase diagram of a square lattice model of XY Spins with direction-dependent interactions
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Zhang, Fan, Guo, Wenan, and Kaul, Ribhu K.
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Condensed Matter - Statistical Mechanics ,Condensed Matter - Strongly Correlated Electrons - Abstract
We study a generalization of the well-known classical two-dimensional square lattice compass model of XY spins (sometimes referred to as the 90$^\circ$ compass model), which interpolates between the XY model and the compass model. Our model possesses the combined $C_4$ lattice and spin rotation symmetry of the compass model but is free of its fine-tuned subsystem symmetries. Using both field theoretic arguments and Monte Carlo simulations, we find that our model possesses a line of critical points with continuously varying exponents of the Ashkin-Teller type terminating at the four-state Potts point. Further, our Monte Carlo study uncovers that beyond the four-state Potts point, the line of phase transition is connected to the lattice-nematic Ising phase transition in the square lattice compass model through a region of first-order transitions., Comment: 13 pages, 15figures
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- 2024
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36. Demonstrating Mobile Manipulation in the Wild: A Metrics-Driven Approach
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Bajracharya, Max, Borders, James, Cheng, Richard, Helmick, Dan, Kaul, Lukas, Kruse, Dan, Leichty, John, Ma, Jeremy, Matl, Carolyn, Michel, Frank, Papazov, Chavdar, Petersen, Josh, Shankar, Krishna, and Tjersland, Mark
- Subjects
Computer Science - Robotics - Abstract
We present our general-purpose mobile manipulation system consisting of a custom robot platform and key algorithms spanning perception and planning. To extensively test the system in the wild and benchmark its performance, we choose a grocery shopping scenario in an actual, unmodified grocery store. We derive key performance metrics from detailed robot log data collected during six week-long field tests, spread across 18 months. These objective metrics, gained from complex yet repeatable tests, drive the direction of our research efforts and let us continuously improve our system's performance. We find that thorough end-to-end system-level testing of a complex mobile manipulation system can serve as a reality-check for state-of-the-art methods in robotics. This effectively grounds robotics research efforts in real world needs and challenges, which we deem highly useful for the advancement of the field. To this end, we share our key insights and takeaways to inspire and accelerate similar system-level research projects., Comment: Presented at RSS 2023 [Best Demo Paper Award]
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- 2024
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37. Interferon-β deficiency alters brain response to chronic HIV-1 envelope protein exposure in a transgenic model of NeuroHIV
- Author
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Singh, Hina, Koury, Jeffrey, Maung, Ricky, Roberts, Amanda J, and Kaul, Marcus
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Biomedical and Clinical Sciences ,Biological Psychology ,Immunology ,Medical Microbiology ,Psychology ,Genetics ,Sexually Transmitted Infections ,Behavioral and Social Science ,Brain Disorders ,Basic Behavioral and Social Science ,Acquired Cognitive Impairment ,Neurodegenerative ,Mental Health ,Women's Health ,Infectious Diseases ,Neurosciences ,HIV/AIDS ,Underpinning research ,1.1 Normal biological development and functioning ,Mental health ,Neurological ,Animals ,Female ,Male ,Mice ,Brain ,HIV Infections ,HIV-1 ,Interferon-beta ,Mice ,Transgenic ,Interferon beta ,IFN beta knockout ,HIVgp120-transgenic ,HIV associated neurocognitive disorder ,Behavior deficits ,P38 MAPK ,ERK1/2 signaling ,Sexual dimorphism ,IFNβ knockout ,Neurology & Neurosurgery ,Biological psychology - Abstract
Human immunodeficiency virus-1 (HIV-1) infects the central nervous system (CNS) and causes HIV-associated neurocognitive disorders (HAND) in about half of the population living with the virus despite combination anti-retroviral therapy (cART). HIV-1 activates the innate immune system, including the production of type 1 interferons (IFNs) α and β. Transgenic mice expressing HIV-1 envelope glycoprotein gp120 (HIVgp120tg) in the CNS develop memory impairment and share key neuropathological features and differential CNS gene expression with HIV patients, including the induction of IFN-stimulated genes (ISG). Here we show that knocking out IFNβ (IFNβKO) in HIVgp120tg and non-tg control mice impairs recognition and spatial memory, but does not affect anxiety-like behavior, locomotion, or vision. The neuropathology of HIVgp120tg mice is only moderately affected by the KO of IFNβ but in a sex-dependent fashion. Notably, in cerebral cortex of IFNβKO animals presynaptic terminals are reduced in males while neuronal dendrites are reduced in females. The IFNβKO results in the hippocampal CA1 region of both male and female HIVgp120tg mice in an ameliorated loss of neuronal presynaptic terminals but no protection of neuronal dendrites. Only female IFNβ-deficient HIVgp120tg mice display diminished microglial activation in cortex and hippocampus and increased astrocytosis in hippocampus compared to their IFNβ-expressing counterparts. RNA expression for some immune genes and ISGs is also affected in a sex-dependent way. The IFNβKO abrogates or diminishes the induction of MX1, DDX58, IRF7 and IRF9 in HIVgp120tg brains of both sexes. Expression analysis of neurotransmission related genes reveals an influence of IFNβ on multiple components with more pronounced changes in IFNβKO females. In contrast, the effects of IFNβKO on MAPK activities are independent of sex with pronounced reduction of active ERK1/2 but also of active p38 in the HIVgp120tg brain. In summary, our findings show that the absence of IFNβ impairs memory dependent behavior and modulates neuropathology in HIVgp120tg brains, indicating that its absence may facilitate development of HAND. Moreover, our data suggests that endogenous IFNβ plays a vital role in maintaining neuronal homeostasis and memory function.
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- 2024
38. A critical role for Macrophage-derived Cysteinyl-Leukotrienes in HIV-1 induced neuronal injury
- Author
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Yuan, Nina Y, Medders, Kathryn E, Sanchez, Ana B, Shah, Rohan, de Rozieres, Cyrus M, Ojeda-Juárez, Daniel, Maung, Ricky, Williams, Roy, Gelman, Benjamin B, Baaten, Bas J, Roberts, Amanda J, and Kaul, Marcus
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Immunology ,Acquired Cognitive Impairment ,Sexually Transmitted Infections ,Infectious Diseases ,Neurodegenerative ,Neurosciences ,HIV/AIDS ,Brain Disorders ,2.1 Biological and endogenous factors ,Aetiology ,Infection ,Neurological ,Mice ,Humans ,Animals ,HIV-1 ,Macrophages ,Leukotrienes ,Neurons ,p38 Mitogen-Activated Protein Kinases ,Mice ,Transgenic ,HIV Infections ,Cysteine ,HIV ,Neurotoxicity ,Cysteinyl leukotrienes ,Knockout ,HIVgp120-transgenic ,HIV associated neurocognitive disorder ,Behavior deficits ,P38 MAPK ,ERK1/2 signaling ,Psychology ,Neurology & Neurosurgery ,Biological psychology - Abstract
Macrophages (MΦ) infected with human immunodeficiency virus (HIV)-1 or activated by its envelope protein gp120 exert neurotoxicity. We found previously that signaling via p38 mitogen-activated protein kinase (p38 MAPK) is essential to the neurotoxicity of HIVgp120-stimulated MΦ. However, the associated downstream pathways remained elusive. Here we show that cysteinyl-leukotrienes (CysLT) released by HIV-infected or HIVgp120 stimulated MΦ downstream of p38 MAPK critically contribute to neurotoxicity. SiRNA-mediated or pharmacological inhibition of p38 MAPK deprives MΦ of CysLT synthase (LTC4S) and, pharmacological inhibition of the cysteinyl-leukotriene receptor 1 (CYSLTR1) protects cerebrocortical neurons against toxicity of both gp120-stimulated and HIV-infected MΦ. Components of the CysLT pathway are differentially regulated in brains of HIV-infected individuals and a transgenic mouse model of NeuroHIV (HIVgp120tg). Moreover, genetic ablation of LTC4S or CysLTR1 prevents neuronal damage and impairment of spatial memory in HIVgp120tg mice. Altogether, our findings suggest a novel critical role for cysteinyl-leukotrienes in HIV-associated brain injury.
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- 2024
39. Physical science research needed to evaluate the viability and risks of marine cloud brightening.
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Feingold, Graham, Ghate, Virendra, Russell, Lynn, Blossey, Peter, Cantrell, Will, Christensen, Matthew, Diamond, Michael, Gettelman, Andrew, Glassmeier, Franziska, Gryspeerdt, Edward, Haywood, James, Hoffmann, Fabian, Kaul, Colleen, Lebsock, Matthew, McComiskey, Allison, McCoy, Daniel, Ming, Yi, Mülmenstädt, Johannes, Possner, Anna, Prabhakaran, Prasanth, Quinn, Patricia, Schmidt, K, Shaw, Raymond, Singer, Clare, Sorooshian, Armin, Toll, Velle, Wan, Jessica, Wood, Robert, Yang, Fan, Zhang, Jianhao, and Zheng, Xue
- Abstract
Marine cloud brightening (MCB) is the deliberate injection of aerosol particles into shallow marine clouds to increase their reflection of solar radiation and reduce the amount of energy absorbed by the climate system. From the physical science perspective, the consensus of a broad international group of scientists is that the viability of MCB will ultimately depend on whether observations and models can robustly assess the scale-up of local-to-global brightening in todays climate and identify strategies that will ensure an equitable geographical distribution of the benefits and risks associated with projected regional changes in temperature and precipitation. To address the physical science knowledge gaps required to assess the societal implications of MCB, we propose a substantial and targeted program of research-field and laboratory experiments, monitoring, and numerical modeling across a range of scales.
- Published
- 2024
40. A Polynomial Method for Counting Colorings of Sparse Graphs
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Dahlberg, Samantha L., Kaul, Hemanshu, and Mudrock, Jeffrey A.
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Mathematics - Combinatorics ,05C15, 12E10, 05C25, 05C30, 05C31, 05A99 - Abstract
The notion of $S$-labeling of graphs, where $S$ is a subset of a symmetric group, was introduced in 2019 by Jin, Wong, and Zhu. This notion provides the framework for a common generalization of various well studied notions of graph coloring, including classical coloring, signed $k$-coloring, signed $\mathbb{Z}_k$-coloring, DP (or correspondence) coloring, group coloring, and coloring of gained graphs. In this paper, we present a unified and simple polynomial method for giving exponential lower bounds on the number of colorings of an $S$-labeled graph for all such $S$. This algebraic technique allows us to prove new lower bounds on the number of colorings of any $S$-labeling of graphs satisfying certain sparsity conditions. We also investigate how the structure of $S$ can be exploited to improve the applicability of these bounds. Our results give new lower bounds on the number of DP-colorings, and consequently the number of all types of colorings listed above. This includes the chromatic polynomial and the number of list colorings of families of planar graphs, and the number of colorings of signed graphs. These enumerative bounds improve previously known results or are the first such known results., Comment: 25 pages, 2 figures
- Published
- 2023
41. Pressure-Induced Negative-Positive Magnetoresistance Crossover Near Metal-Insulator Transition in La_{0.8}Ag_{0.1}MnO_{3}
- Author
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Gamzatov, A. G., Arslanov, T. R., Kaul, A. R., and Alisultanov, Z. Z.
- Subjects
Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Materials Science - Abstract
We investigated the effect of high pressure on the field dependences of magnetoresistance (MR) in La_{0.8}Ag_{0.1}MnO_{3} near the metal-insulator transition temperature. Our results showed that an increase in pressure results in a decrease in the magnitude of negative MR. At pressures $P\geqslant5.6$ GPa and magnetic fields up to 4 kOe, we observed a positive MR. However, with a further increase in magnetic field (>4 kOe), the MR again became negative. Therefore, we discovered a "negative-positive" MR crossover induced by high pressure near the transition temperature. We supported our experimental findings with a qualitative theoretical interpretation using the electron-hole model of MR. This theory explains observed the MR sign change.
- Published
- 2023
42. Thoracoabdominal Flap Closure for Large Post Pectoralis Major Myocutaneous Flap Donor Site in Advanced Oral Cancer: An Innovative Approach in Resource Constraint Setting
- Author
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Kaul, Pallvi, Tiwari, Ajeet Ramamani, Kumar, Rahul, Sadhu, Sanjay, Govil, Nishith, and Garg, Pankaj Kumar
- Published
- 2024
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43. Daughter of the Chenab : Krishna Sobti
- Author
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Cour, Ajeet and Kaul, Ranjana
- Published
- 2024
44. Multi-product dynamic advertisement planning in a segmented market
- Author
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Aggarwal Sugandha, Gupta Anshu, Kaul Arshia, Krishnamoorthy Mohan, and Jha P.C.
- Subjects
media planning ,segmented market ,multiple products ,cross-product effect ,retention factor ,dynamic model ,Management information systems ,T58.6-58.62 - Abstract
In this paper, a dynamic multi-objective linear integer programming model is proposed to optimally distribute a firm’s advertising budget among multiple products and media in a segmented market. To make the media plan responsive to the changes in the market, the distribution is carried out dynamically by dividing the planning horizon into smaller periods. The model incorporates the effect of the previous period advertising reach on the current period (taken through retention factor), and it also considers cross-product effect of simultaneously advertising different products. An application of the model is presented for an insurance firm that markets five different products, using goal programming approach.
- Published
- 2017
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45. Assessment of artificial intelligence-based digital learning systems in higher education amid the pandemic using analytic hierarchy
- Author
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Singh, Vikrant Vikram, Kumar, Nishant, Singh, Shailender, Kaul, Meenakshi, Gupta, Aditya Kumar, and Kapur, P. K.
- Published
- 2024
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46. Nanoformulation of dasatinib cannot overcome therapy resistance of pancreatic cancer cells with low LYN kinase expression
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Kaul, Marilyn, Sanin, Ahmed Y., Shi, Wenjie, Janiak, Christoph, and Kahlert, Ulf D.
- Published
- 2024
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47. Prevalence and risk of sexual violence victimization among mental health service users: a systematic review and meta-analyses
- Author
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Kaul, Anjuli, Connell-Jones, Laura, Paphitis, Sharli Anne, and Oram, Sian
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- 2024
- Full Text
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48. Myocardial strain assessment in the human fetus by cardiac MRI using Doppler ultrasound gating and feature tracking
- Author
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Dargahpour Barough, Maryam, Tavares de Sousa, Manuela, Hergert, Bettina, Fischer, Roland, Huber, Lukas, Seliger, Jan Moritz, Kaul, Michael Gerhard, Adam, Gerhard, Herrmann, Jochen, Bannas, Peter, and Schoennagel, Bjoern P.
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- 2024
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49. Annual and seasonal assessment of spatiotemporal variation in PM2.5 and gaseous air pollutants in Bengaluru, India
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Suthar, Gourav, Singhal, Rajat Prakash, Khandelwal, Sumit, Kaul, Nivedita, Parmar, Vinod, and Singh, Abhay Pratap
- Published
- 2024
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50. Assessment of Chemotherapy Knowledge and Practices Among Breast Surgeons in India: Identifying Gaps and Areas for Improvement
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Jakhetiya, Ashish, Kaul, Priyanka, Meena, Jitendra Kumar, Yadav, Ajay Kumar, Tiwari, Ajeet Ramamani, Kumar, Rahul, and Garg, Pankaj Kumar
- Published
- 2024
- Full Text
- View/download PDF
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