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3. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

Author

Adams, Hadie, Agnoletti, Vanni, Allanson, Judith, Amrein, Krisztina, Andaluz, Norberto, Anke, Audny, Antoni, Anna, van As, Arjan Bastiaan, Audibert, Gérard, Azaševac, Antun, Azouvi, Philippe, Azzolini, Maria Luisa, Baciu, Camelia, Badenes, Rafael, Barlow, Karen M, Bartels, Ronald, Bauerfeind, Ursula, Beauchamp, Miriam, Beer, Darcy, Beer, Ronny, Belda, Francisco Javier, Bellander, Bo-Michael, Bellier, Rémy, Benali, Habib, Benard, Thierry, Beqiri, Valzerda, Beretta, Luigi, Bernard, Francis, Bertolini, Guido, Bilotta, Federico, Blaabjerg, Morten, den Boogert, Hugo, Boutis, Kathy, Bouzat, Pierre, Brooks, Brian, Brorsson, Camilla, Bullinger, Monika, Burns, Emma, Calappi, Emiliana, Cameron, Peter, Carise, Elsa, Castaño-León, Ana M, Causin, Francesco, Chevallard, Giorgio, Chieregato, Arturo, Christie, Brian, Cnossen, Maryse, Coles, Jonathan, Collett, Johnny, Della Corte, Francesco, Craig, William, Csato, Gabor, Csomos, Akos, Curry, Nicola, Dahyot-Fizelier, Claire, Dawes, Helen, DeMatteo, Carol, Depreitere, Bart, Dewey, Deborah, van Dijck, Jeroen, Đilvesi, Đula, Dippel, Diederik, Dizdarevic, Kemal, Donoghue, Emma, Duek, Or, Dulière, Guy-Loup, Dzeko, Adelaida, Eapen, George, Emery, Carolyn A, English, Shane, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feng, Junfeng, Fergusson, Dean, Figaji, Anthony, Fleming, Joanne, Foks, Kelly, Francony, Gilles, Freedman, Stephen, Freo, Ulderico, Frisvold, Shirin K, Gagnon, Isabelle, Galanaud, Damien, Gantner, Dashiell, Giraud, Benoit, Glocker, Ben, Golubovic, Jagoš, Gómez López, Pedro A, Gordon, Wayne A, Gradisek, Primoz, Gravel, Jocelyn, Griesdale, Donald, Grossi, Francesca, Haagsma, Juanita A, Håberg, Asta Kristine, Haitsma, Iain, Van Hecke, Wim, Helbok, Raimund, Helseth, Eirik, van Heugten, Caroline, Hoedemaekers, Cornelia, Höfer, Stefan, Horton, Lindsay, Hui, Jiyuan, Huijben, Jilske Antonia, Hutchinson, Peter J, Jacobs, Bram, van der Jagt, Mathieu, Jankowski, Stefan, Janssens, Koen, Jelaca, Bojan, Jones, Kelly M, Kamnitsas, Konstantinos, Kaps, Rafael, Karan, Mladen, Katila, Ari, Kaukonen, Kirsi-Maija, De Keyser, Véronique, Kivisaari, Riku, Kolias, Angelos G, Kolumbán, Bálint, Kolundžija, Ksenija, Kondziella, Daniel, Koskinen, Lars-Owe, Kovács, Noémi, Kramer, Andreas, Kutsogiannis, Demitri, Kyprianou, Theodoros, Lagares, Alfonso, Lamontagne, François, Latini, Roberto, Lauzier, François, Lazar, Isaac, Ledig, Christian, Lefering, Rolf, Legrand, Valerie, Levi, Leon, Lightfoot, Roger, Lozano, Angels, MacDonald, Stephen, Major, Sebastian, Manara, Alex, Manhes, Pauline, Maréchal, Hugues, Martino, Costanza, Masala, Alessandro, Masson, Serge, Mattern, Julia, McFadyen, Bradford, McMahon, Catherine, Meade, Maureen, Melegh, Béla, Menovsky, Tomas, Moore, Lynne, Morgado Correia, Marta, Morganti-Kossmann, Maria Cristina, Muehlan, Holger, Mukherjee, Pratik, Murray, Lynnette, van der Naalt, Joukje, Negru, Ancuta, Nelson, David, Nieboer, Daan, Noirhomme, Quentin, Nyirádi, József, Oddo, Mauro, Okonkwo, David O, Oldenbeuving, Annemarie W, Ortolano, Fabrizio, Osmond, Martin, Payen, Jean-François, Perlbarg, Vincent, Persona, Paolo, Pichon, Nicolas, Piippo-Karjalainen, Anna, Pili-Floury, Sébastien, Pirinen, Matti, Ple, Horia, Poca, Maria Antonia, Posti, Jussi, Van Praag, Dominique, Ptito, Alain, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Real, Ruben G L, Reed, Nick, Rhodes, Jonathan, Robertson, Claudia, Rocka, Saulius, Røe, Cecilie, Røise, Olav, Roks, Gerwin, Rosand, Jonathan, Rosenfeld, Jeffrey V, Rosenlund, Christina, Rosenthal, Guy, Rossi, Sandra, Rueckert, Daniel, de Ruiter, Godard C W, Sacchi, Marco, Sahakian, Barbara J, Sahuquillo, Juan, Sakowitz, Oliver, Salvato, Gerardo, Sánchez-Porras, Renán, Sándor, János, Sangha, Grinder, Schäfer, Nadine, Schmidt, Silke, Schneider, Kathryn J, Schnyer, David, Schöhl, Herbert, Schoonman, Guus G, Schou, Rico Frederik, Sir, Özcan, Skandsen, Toril, Smeets, Dirk, Sorinola, Abayomi, Stamatakis, Emmanuel, Stevanovic, Ana, Stevens, Robert D, Sundström, Nina, Taccone, Fabio Silvio, Takala, Riikka, Tanskanen, Päivi, Taylor, Mark Steven, Telgmann, Ralph, Temkin, Nancy, Teodorani, Guido, Thomas, Matt, Tolias, Christos M, Trapani, Tony, Turgeon, Alexis, Vajkoczy, Peter, Valadka, Alex B, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, Vargiolu, Alessia, Vega, Emmanuel, Verheyden, Jan, Vik, Anne, Vilcinis, Rimantas, Vleggeert-Lankamp, Carmen, Vogt, Lidia, Volovici, Victor, Voormolen, Daphne C, Vulekovic, Peter, Vande Vyvere, Thijs, Van Waesberghe, Julia, Wessels, Lars, Wildschut, Eno, Williams, Guy, Winkler, Maren K L, Wolf, Stefan, Wood, Gordon, Xirouchaki, Nektaria, Younsi, Alexander, Zaaroor, Menashe, Zelinkova, Veronika, Zemek, Roger, Zumbo, Fabrizio, Maas, Andrew I R, Menon, David K, Adelson, P David, Andelic, Nada, Bell, Michael J, Belli, Antonio, Bragge, Peter, Brazinova, Alexandra, Büki, András, Chesnut, Randall M, Citerio, Giuseppe, Coburn, Mark, Cooper, D Jamie, Crowder, A Tamara, Czeiter, Endre, Czosnyka, Marek, Diaz-Arrastia, Ramon, Dreier, Jens P, Duhaime, Ann-Christine, Ercole, Ari, van Essen, Thomas A, Feigin, Valery L, Gao, Guoyi, Giacino, Joseph, Gonzalez-Lara, Laura E, Gruen, Russell L, Gupta, Deepak, Hartings, Jed A, Hill, Sean, Jiang, Ji-yao, Ketharanathan, Naomi, Kompanje, Erwin J O, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Levin, Harvey, Lingsma, Hester F, Maegele, Marc, Majdan, Marek, Manley, Geoffrey, Marsteller, Jill, Mascia, Luciana, McFadyen, Charles, Mondello, Stefania, Newcombe, Virginia, Palotie, Aarno, Parizel, Paul M, Peul, Wilco, Piercy, James, Polinder, Suzanne, Puybasset, Louis, Rasmussen, Todd E, Rossaint, Rolf, Smielewski, Peter, Söderberg, Jeannette, Stanworth, Simon J, Stein, Murray B, von Steinbüchel, Nicole, Stewart, William, Steyerberg, Ewout W, Stocchetti, Nino, Synnot, Anneliese, Te Ao, Braden, Tenovuo, Olli, Theadom, Alice, Tibboel, Dick, Videtta, Walter, Wang, Kevin K W, Williams, W Huw, Wilson, Lindsay, and Yaffe, Kristine

Published
2017
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5. Ubiquitin C‐terminal hydrolase L1 after out‐of‐hospital cardiac arrest.

Author

Wihersaari, Lauri, Reinikainen, Matti, Tiainen, Marjaana, Bendel, Stepani, Kaukonen, Kirsi‐Maija, Vaahersalo, Jukka, Romppanen, Jarkko, Pettilä, Ville, and Skrifvars, Markus B.

Subjects
CARDIAC arrest, UBIQUITIN, RECEIVER operating characteristic curves, DEUBIQUITINATING enzymes, INTENSIVE care units
Abstract

Background: We studied the prognostic ability of serum ubiquitin C‐terminal hydrolase L1 (UCH‐L1) after out‐of‐hospital cardiac arrest (OHCA), compared to that of neuron‐specific enolase (NSE). Methods: In this post‐hoc analysis of the FINNRESUSCI study, we measured serum concentrations of UCH‐L1 in 249 OHCA patients treated in 21 Finnish intensive care units in 2010–2011. We evaluated the ability of UCH‐L1 to predict unfavourable outcome at 12 months (defined as cerebral performance category 3–5) by assessing the area under the receiver operating characteristic curve (AUROC), in comparison with NSE. Results: The concentrations of UCH‐L1 were higher in patients with unfavourable outcome than for those with favourable outcome: median concentration 10.8 ng/mL (interquartile range, 7.5–18.5 ng/mL) versus 7.8 ng/mL (5.9–11.8 ng/mL) at 24 h (p <.001), and 16.2 ng/mL (12.2–27.7 ng/mL) versus 11.5 ng/mL (9.0–17.2 ng/mL) (p <.001) at 48 h after OHCA. For UCH‐L1 as a 12‐month outcome predictor, the AUROC was 0.66 (95% confidence interval, 0.60–0.73) at 24 h and 0.66 (0.59–0.74) at 48 h. For NSE, the AUROC was 0.66 (0.59–0.73) at 24 h and 0.72 (0.65–0.80) at 48 h. The prognostic ability of UCH‐L1 was not different from that of NSE at 24 h (p =.82) and at 48 h (p =.23). Conclusion: Concentrations of UCH‐L1 in serum were higher in patients with unfavourable outcome than in those with favourable outcome. However, the ability of UCH‐L1 to predict unfavourable outcome after OHCA was only moderate and not superior to that of NSE. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Three-year mortality in 30-day survivors of critical care with acute kidney injury: data from the prospective observational FINNAKI study

Author

Mildh, Henriikka, Pettilä, Ville, Korhonen, Anna-Maija, Karlsson, Sari, Ala-Kokko, Tero, Reinikainen, Matti, Vaara, Suvi T., Laru-Sompa, Raili, Pulkkinen, Anni, Saarelainen, Minna, Reilama, Mikko, Tolmunen, Sinikka, Rantalainen, Ulla, Miettinen, Marja, Suvela, Markku, Pesola, Katrine, Saastamoinen, Pekka, Kauppinen, Sirpa, Pettilä, Ville, Kaukonen, Kirsi-Maija, Nisula, Sara, Vaara, Suvi, Suojaranta-Ylinen, Raili, Mildh, Leena, Haapio, Mikko, Nurminen, Laura, Sutinen, Sari, Pettilä, Leena, Laitinen, Helinä, Syrjä, Heidi, Henttonen, Kirsi, Lappi, Elina, Boman, Hillevi, Varpula, Tero, Porkka, Päivi, Sivula, Mirka, Rahkonen, Mira, Tsurkka, Anne, Nieminen, Taina, Pirttinen, Niina, Alaspää, Ari, Salanto, Ville, Juntunen, Hanna, Sanisalo, Teija, Parviainen, Ilkka, Uusaro, Ari, Ruokonen, Esko, Bendel, Stepani, Rissanen, Niina, Lång, Maarit, Rahikainen, Sari, Rissanen, Saija, Ahonen, Merja, Halonen, Elina, Vaskelainen, Eija, Poukkanen, Meri, Lintula, Esa, Suominen, Sirpa, Heikkinen, Jorma, Lavander, Timo, Heinonen, Kirsi, Juopperi, Anne-Mari, Kaminski, Tadeusz, Gäddnäs, Fiia, Kuusela, Tuija, Roiko, Jane, Karlsson, Sari, Reinikainen, Matti, Surakka, Tero, Jyrkönen, Helena, Eiserbeck, Tanja, Kallinen, Jaana, Ala-Kokko, Tero, Laurila, Jouko, Sälkiö, Sinikka, Lund, Vesa, Tuominen, Päivi, Perkola, Pauliina, Tuominen, Riikka, Hietaranta, Marika, Johansson, Satu, Hovilehto, Seppo, Kirsi, Anne, Tiainen, Pekka, Myllärinen, Tuija, Leino, Pirjo, Toropainen, Anne, Kuitunen, Anne, Tenhunen, Jyrki, Leppänen, Ilona, Levoranta, Markus, Hoppu, Sanna, Sauranen, Jukka, Kukkurainen, Atte, Kortelainen, Samuli, Varila, Simo, Inkinen, Outi, Koivuviita, Niina, Kotamäki, Jutta, Laine, Anu, Koivisto, Simo-Pekka, Hautamäki, Raku, Skinnar, Maria, and the FINNAKI Study Group

Published
2016
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8. Reply to Rhodes et al

Author

Roberts, Jason A., Paul, Sanjoy K., Akova, Murat, Bassetti, Matteo, De Waele, Jan J., Dimopoulos, George, Kaukonen, Kirsi-Maija, Koulenti, Despoina, Martin, Claude, Montravers, Philippe, Rello, Jordi, Rhodes, Andrew, Starr, Therese, Wallis, Steven C., and Lipman, Jeffrey

Published
2014
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11. Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort

Author

Abdul-Aziz, Mohd H., Lipman, Jeffrey, Akova, Murat, Bassetti, Matteo, De Waele, Jan J., Dimopoulos, George, Dulhunty, Joel, Kaukonen, Kirsi-Maija, Koulenti, Despoina, Martin, Claude, Montravers, Philippe, Rello, Jordi, Rhodes, Andrew, Starr, Therese, Wallis, Steven C., Roberts, Jason A., Roberts, Jason A., Lipman, Jeffrey, Starr, Therese, Wallis, Steven C., Paul, Sanjoy, Ribas, Antonio Margarit, De Waele, Jan J., De Crop, Luc, Spapen, Herbert, Wauters, Joost, Dugernier, Thierry, Jorens, Philippe, Dapper, Ilse, De Backer, Daniel, Taccone, Fabio S., Rello, Jordi, Ruano, Laura, Afonso, Elsa, Alvarez-Lerma, Francisco, Gracia-Arnillas, Maria Pilar, Fernández, Francisco, Feijoo, Neus, Bardolet, Neus, Rovira, Assumpta, Garro, Pau, Colon, Diana, Castillo, Carlos, Fernado, Juan, Lopez, Maria Jesus, Fernandez, Jose Luis, Arribas, Ana Maria, Teja, Jose Luis, Ots, Elsa, Montejo, Juan Carlos, Catalan, Mercedes, Prieto, Isidro, Gonzalo, Gloria, Galvan, Beatriz, Blasco, Miguel Angel, Meyer, Estibaliz, Del Nogal, Frutos, Vidaur, Loreto, Sebastian, Rosa, Garde, Pila Marco, del Mar Martin Velasco, Maria, Crespo, Rafael Zaragoza, Esperatti, Mariano, Torres, Antoni, Montravers, Philippe, Baldesi, Olivier, Dupont, Herve, Mahjoub, Yazine, Lasocki, Sigismond, Constantin, Jean Michel, Payen, Jean François, Martin, Claude, Albanese, Jacques, Malledant, Yannick, Pottecher, Julien, Lefrant, Jean-Yves, Jaber, Samir, Joannes-Boyau, Olivier, Orban, Christophe, Ostermann, Marlies, McKenzie, Catherine, Berry, Willaim, Smith, John, Lei, Katie, Rubulotta, Francesca, Gordon, Anthony, Brett, Stephen, Stotz, Martin, Templeton, Maie, Rhodes, Andrew, Ebm, Claudia, Moran, Carl, Kaukonen, Kirsi-Maija, Pettilä, Ville, Dimopoulos, George, Koulenti, Despoina, Xristodoulou, Aglaia, Theodorou, Vassiliki, Kouliatsis, Georgios, Sertaridou, Eleni, Anthopoulos, Georgios, Choutas, George, Rantis, Thanos, Karatzas, Stylianos, Balla, Margarita, Papanikolaou, Metaxia, Myrianthefs, Pavlos, Gavala, Alexandra, Fildisis, Georgios, Koutsoukou, Antonia, Kyriakopoulou, Magdalini, Petrochilou, Kalomoira, Kompoti, Maria, Michalia, Martha, Clouva-Molyvdas, Fillis-Maria, Gkiokas, Georgios, Nikolakopoulos, Fotios, Psychogiou, Vasiliki, Malliotakis, Polychronis, Akoumianaki, Evangelia, Lilitsis, Emmanouil, Koulouras, Vassilios, Nakos, George, Kalogirou, Mihalis, Komnos, Apostolos, Zafeiridis, Tilemachos, Chaintoutis, Christos, Arvaniti, Kostoula, Matamis, Dimitrios, Chaintoutis, Christos, Kydona, Christina, Gritsi-Gerogianni, Nikoleta, Giasnetsova, Tatiana, Giannakou, Maria, Soultati, Ioanna, Chytas, Ilias, Antoniadou, Eleni, Antipa, Elli, Lathyris, Dimitrios, Koukoubani, Triantafyllia, Paraforou, Theoniki, Spiropoulou, Kyriaki, Bekos, Vasileios, Spring, Anna, Kalatzi, Theodora, Nikolaou, Hara, Laskou, Maria, Strouvalis, Ioannis, Aloizos, Stavros, Kapogiannis, Spyridon, Soldatou, Ourania, Bassetti, Matteo, Adembri, Chiara, Villa, Gianluca, Giarratano, Antonio, Raineri, Santi Maurizio, Cortegiani, Andrea, Montalto, Francesca, Strano, Maria Teresa, Ranieri, V. Marco, Sandroni, Claudio, De Pascale, Gennaro, Molin, Alexandre, Pelosi, Paolo, Montagnani, Luca, Urbino, Rosario, Mastromauro, Ilaria, De Rosa, Francesco G., Ranieri, V. Marco, Cardoso, Teresa, Afonso, Susana, Gonçalves-Pereira, João, Baptista, João Pedro, Akova, Murat, and Özveren, Arife

Published
2016
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19. Therapeutic hypothermia after out-of-hospital cardiac arrest in Finnish intensive care units: the FINNRESUSCI study

Author

Vaahersalo, Jukka, Hiltunen, Pamela, Tiainen, Marjaana, Oksanen, Tuomas, Kaukonen, Kirsi-Maija, Kurola, Jouni, and Ruokonen, Esko

Subjects
Medical research -- Health aspects, Medicine, Experimental -- Health aspects, Mortality -- Finland, Hypothermia -- Care and treatment, Cardiac arrest -- Care and treatment, Health care industry
Abstract

Purpose We aimed to evaluate post-resuscitation care, implementation of therapeutic hypothermia (TH) and outcomes of intensive care unit (ICU)-treated out-of-hospital cardiac arrest (OHCA) patients in Finland. Methods We included all adult OHCA patients admitted to 21 ICUs in Finland from March 1, 2010 to February 28, 2011 in this prospective observational study. Patients were followed (mortality and neurological outcome evaluated by Cerebral Performance Categories, CPC) within 1 year after cardiac arrest. Results This study included 548 patients treated after OHCA. Of those, 311 patients (56.8 %) had a shockable initial rhythm (incidence of 7.4/100,000/year) and 237 patients (43.2 %) had a non-shockable rhythm (incidence of 5.6/100,000/year). At ICU admission, 504 (92 %) patients were unconscious. TH was given to 241/281 (85.8 %) unconscious patients resuscitated from shockable rhythms, with unfavourable 1-year neurological outcome (CPC 3-4-5) in 42.0 % with TH versus 77.5 % without TH (p < 0.001). TH was given to 70/223 (31.4 %) unconscious patients resuscitated from non-shockable rhythms, with 1-year CPC of 3-4-5 in 80.6 % (54/70) with TH versus 84.0 % (126/153) without TH (p = 0.56). This lack of difference remained after adjustment for propensity to receive TH in patients with non-shockable rhythms. Conclusions One-year unfavourable neurological outcome of patients with shockable rhythms after TH was lower than in previous randomized controlled trials. However, our results do not support use of TH in patients with non-shockable rhythms., Author(s): Jukka Vaahersalo [sup.1] [sup.11], Pamela Hiltunen [sup.2], Marjaana Tiainen [sup.3], Tuomas Oksanen [sup.1], Kirsi-Maija Kaukonen [sup.1], Jouni Kurola [sup.2], Esko Ruokonen [sup.2], Jyrki Tenhunen [sup.4] [sup.5], Tero Ala-Kokko [sup.6], [...]

Published
2013
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20. Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study

Author

Nisula, Sara, Kaukonen, Kirsi-Maija, Vaara, Suvi T., Korhonen, Anna-Maija, Poukkanen, Meri, Karlsson, Sari, and Haapio, Mikko

Subjects
Chronic kidney failure -- Risk factors -- Patient outcomes, Mortality -- Finland, Diuretics, Health care industry
Abstract

Purpose We aimed to determine the incidence, risk factors and outcome of acute kidney injury (AKI) in Finnish ICUs. Methods This prospective, observational, multi-centre study comprised adult emergency admissions and elective patients whose stay exceeded 24 h during a 5-month period in 17 Finnish ICUs. We defined AKI first by the Acute Kidney Injury Network (AKIN) criteria supplemented with a baseline creatinine and second with the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. We screened the patients' AKI status and risk factors for up to 5 days. Results We included 2,901 patients. The incidence (95 % confidence interval) of AKI was 39.3 % (37.5-41.1 %). The incidence was 17.2 % (15.8-18.6 %) for stage 1, 8.0 % (7.0-9.0 %) for stage 2 and 14.1 % (12.8-15.4 %) for stage 3 AKI. Of the 2,901 patients 296 [10.2 % (9.1-11.3 %)] received renal replacement therapy. We received an identical classification with the new KDIGO criteria. The population-based incidence (95 % CI) of ICU-treated AKI was 746 (717-774) per million population per year (reference population: 3,671,143, i.e. 85 % of the Finnish adult population). In logistic regression, pre-ICU hypovolaemia, diuretics, colloids and chronic kidney disease were independent risk factors for AKI. Hospital mortality (95 % CI) for AKI patients was 25.6 % (23.0-28.2 %) and the 90-day mortality for AKI patients was 33.7 % (30.9-36.5 %). All AKIN stages were independently associated with 90-day mortality. Conclusions The incidence of AKI in the critically ill in Finland was comparable to previous large multi-centre ICU studies. Hospital mortality (26 %) in AKI patients appeared comparable to or lower than in other studies., Author(s): Sara Nisula [sup.1], Kirsi-Maija Kaukonen [sup.1], Suvi T. Vaara [sup.1], Anna-Maija Korhonen [sup.1], Meri Poukkanen [sup.2], Sari Karlsson [sup.3] [sup.4], Mikko Haapio [sup.5], Outi Inkinen [sup.6], Ilkka Parviainen [sup.7], [...]

Published
2013
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21. Five-year cost-utility analysis of acute renal replacement therapy: a societal perspective

Author

Laukkanen, Annika, Emaus, Linda, Pettilä, Ville, and Kaukonen, Kirsi-Maija

Subjects
Medical care, Cost of -- Economic aspects -- Analysis -- Social aspects, Medical care -- Quality management, Hospital patients -- Analysis -- Social aspects -- Economic aspects, Health care industry
Abstract

Purpose Assessment of the cost utility (CU) of acute renal replacement therapy (RRT) from a societal perspective during a 5-year follow-up. Methods This was a cross-sectional cohort study in a medical-surgical intensive care unit and an acute RRT unit of 410 consecutive patients treated with acute RRT in Helsinki University Hospital in 2000-2002. Five-year survival and health-related quality of life (HRQoL) were assessed and used to calculate quality-adjusted life years (QALYs) in two ways. They were first calculated for the 5-year follow-up period and, second, estimated for the expected lifetime. HRQoL was assessed by the EuroQol (EQ-5D) in 2003. The cost analysis included hospital costs during index hospitalization along with hospital and societal costs for the following 5 years. The CU ratio was determined as total costs divided by gained QALYs. Results Median survival time for all patients was 0.20 years and the EQ-5D index score was 0.68, 0.18 lower than that of the age- and gender-matched general population. All RRT-treated patients gained 0.10 QALYs/patient and hospital survivors 2.54 QALYs in 5 years. Overall the CU ratio was poor [5 year median 271,116 (29,782-2,177,581) [euro]/QALY]. However, it was acceptable (less than 50,000 [euro]/QALY) in patients who survived for more than a year and did not need chronic RRT. Cost utility decreased with increasing age exceeding 1.0 million [euro]/QALY in the older groups. Conclusions In general, the CU ratio of acute RRT is poor. However, it is acceptable in patients with renal recovery who survive for more than 1 year., Author(s): Annika Laukkanen [sup.1], Linda Emaus [sup.1], Ville Pettilä [sup.1], Kirsi-Maija Kaukonen [sup.1] Author Affiliations: (1) grid.15485.3d, 0000000099505666, Intensive Care Unit, Division of Anaesthesiology and Intensive Care Medicine, Department of [...]

Published
2013
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24. COVID-19-adenovirusvektorirokotteen aiheuttama hyytymishäiriö

Author

Pitkänen, Hanna, Anttila, Veli-Jukka, Forss, Nina, Kaukonen, Kirsi-Maija, Tierala, Ilkka, Lassila, Riitta, HUS Lasten ja nuorten sairaudet, Lastenklinikka, HUS Tulehduskeskus, Neurologian yksikkö, HUS Neurokeskus, Clinicum, HUS Leikkaussalit, teho- ja kivunhoito, Diagnostis-terapeuttinen osasto, HUS Sydän- ja keuhkokeskus, Kardiologian yksikkö, HUS Syöpäkeskus, Sisätautien osasto, and Research Program in Systems Oncology

Subjects
+drug therapy, Blood Platelets, COVID-19 Vaccines, Heparin, +diagnosis, Genetic Vectors, immunoglobulins, Anticoagulants, Immunoglobulins, Intravenous, Fibrinogen, Thrombosis, Blood Coagulation Disorders, Platelet Factor 4, Antibodies, Adenoviridae, +adverse effects, Fibrin Fibrinogen Degradation Products, 3121 Yleislääketiede, sisätaudit ja muut kliiniset lääketieteet, +therapy, +etiology
Abstract

Vertaisarvioitu. COVID-19-infektioiden estämiseen kehitetyt adenovirusvektorirokotteet aiheuttavat erittäin harvinaisena haittavaikutuksena vaikeita hyytymishäiriöitä, joissa kehittyy verihiutaleita aktivoivia vasta-aineita. Tilan kansainvälinen nimitys on vaccine-induced immune thrombotic thrombocytopenia (VITT) tai tromboottinen trombosytopeeninen oireyhtymä (TTS), jolle ominaisia ovat trombosytopenia, positiiviset verihiutaletekijä 4 (PF4) -hepariinivasta-aineet ilman hepariinin käyttöä sekä valtimo- ja laskimotukokset. Hyytymishäiriön nopea diagnosointi on tärkeää, sillä tilaan liittyy jopa 40 %:n kuolleisuus. Hoidon kulmakivet ovat antikoagulaatio muilla kuin hepariinivalmisteilla ja suonensisäisen immunoglobuliinin antaminen trombosyyttiaktivaatiota aiheuttavien vasta-aineiden syrjäyttämiseksi.

Published
2021

25. Additional file 7 of Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation

Author

Turunen, Heidi, Jakob, Stephan M, Ruokonen, Esko, Kaukonen, Kirsi-Maija, Sarapohja, Toni, Apajasalo, Marjo, and Takala, Jukka

Subjects
health care economics and organizations
Abstract

Total intensive care unit (ICU) costs in patients with observed data available from all three time points, without any censoring or data imputations, in the pooled data analysis (S6). Table S5. Total intensive care unit (ICU) costs with dexmedetomidine and current standard care sedatives in the 18 centers whose routine daily ICU cost information the unit cost assumptions in this work were based on (S7).

Published
2021
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28. Additional file 9 of Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation

Author

Turunen, Heidi, Jakob, Stephan M, Ruokonen, Esko, Kaukonen, Kirsi-Maija, Sarapohja, Toni, Apajasalo, Marjo, and Takala, Jukka

Abstract

Total intensive care unit (ICU) cost differences between the study treatment groups in the different sensitivity analyses (S1-S8), based on MIDEX. Table S8. Total ICU cost differences between the study treatment groups in the different sensitivity analyses (S1-S8), based on PRODEX.

Published
2021
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29. Additional file 4 of Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation

Author

Turunen, Heidi, Jakob, Stephan M, Ruokonen, Esko, Kaukonen, Kirsi-Maija, Sarapohja, Toni, Apajasalo, Marjo, and Takala, Jukka

Subjects
health care facilities, manpower, and services
Abstract

Duration of the different intensive care unit (ICU) periods by mechanical ventilation use, and the duration of post-ICU ward stay.

Published
2021
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30. Additional file 8 of Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation

Author

Turunen, Heidi, Jakob, Stephan M, Ruokonen, Esko, Kaukonen, Kirsi-Maija, Sarapohja, Toni, Apajasalo, Marjo, and Takala, Jukka

Subjects
health care economics and organizations
Abstract

Details for Therapeutic Intervention Scoring System (TISS)-based intensive care unit (ICU) cost analyses including sedative costs-pooled data (S8a-b).

Published
2021
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32. Prognostic value of chromogranin A in severe sepsis: data from the FINNSEPSIS study

Author

Røsjø, Helge, Nygård, Ståle, Kaukonen, Kirsi-Maija, Karlsson, Sari, Stridsberg, Mats, Ruokonen, Esko, and Pettilä, Ville

Subjects
Medical research, Medicine, Experimental, Mortality -- Finland, Cardiac patients -- Prognosis, Septic shock -- Prognosis, Health care industry
Abstract

Purpose To assess the prognostic information of chromogranin A (CgA), a marker associated with adrenergic tone and myocardial function, in patients with severe sepsis. Methods CgA levels were measured at the time of study inclusion and 72 h later in 232 patients with severe sepsis recruited from 24 ICUs in Finland (FINNSEPSIS study). Results Sixty-five patients (28 %) died during the index hospitalization. CgA levels at inclusion and after 72 h correlated with several established indices of risk in sepsis. Patients who died during the hospitalization had higher baseline CgA levels than hospital survivors: 14.0 (Q1-3, 7.4-27.4) versus 9.1 (5.9-15.8) nmol/l, P = 0.002, and after 72 h: 16.2 (9.0-31.1) versus 9.8 (6.0-18.0) nmol/l, P = 0.001. Prior cardiovascular disease (P = 0.04) and cardiovascular SOFA levels on day 3 (P = 0.03) were associated with higher CgA levels after 72 h by linear regression. CgA levels on study inclusion and after 72 h were independently associated with hospital mortality by logistic regression: OR (logarithmically transformed CgA levels) 1.95 (95 % CI 1.01-3.77), P = 0.046 and OR 2.03 (95 % CI 1.18-3.49), P = 0.01, respectively. The prognostic accuracy was comparable for CgA measurements and SAPS II score, and the addition of CgA measurements to the SAPS II score improved risk stratification of the patients as assessed by the category-free net reclassification index. A CgA level >6.6 nmol/l on study inclusion was associated with septic shock during the hospitalization. Conclusion CgA levels measured during hospitalization for severe sepsis are associated with cardiovascular dysfunction and may provide additional prognostic information in patients with severe sepsis., Author(s): Helge Røsjø [sup.1] [sup.2], Ståle Nygård [sup.2] [sup.3], Kirsi-Maija Kaukonen [sup.4], Sari Karlsson [sup.5], Mats Stridsberg [sup.6], Esko Ruokonen [sup.7], Ville Pettilä [sup.4], Torbjørn Omland [sup.1] [sup.2] Author Affiliations: [...]

Published
2012
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36. Usefulness of neuron specific enolase in prognostication after cardiac arrest : Impact of age and time to ROSC

Author

FINNRESUSCI Study Grp, Wihersaari, Lauri, Tiainen, Marjaana, Skrifvars, Markus B., Bendel, Stepani, Kaukonen, Kirsi-Maija, Vaahersalo, Jukka, Romppanen, Jarkko, Pettilä, Ville, Reinikainen, Matti, HUS Neurocenter, Neurologian yksikkö, Department of Diagnostics and Therapeutics, HUS Emergency Medicine and Services, Anestesiologian yksikkö, and HUS Perioperative, Intensive Care and Pain Medicine

Subjects
medicine.medical_specialty, Resuscitation, Time Factors, THERAPEUTIC HYPOTHERMIA, Enolase, SOCIETY, PROTEIN, 030204 cardiovascular system & hematology, Emergency Nursing, Return of spontaneous circulation, 03 medical and health sciences, 0302 clinical medicine, TARGETED TEMPERATURE MANAGEMENT, NSE, Predictive Value of Tests, Intensive care, Internal medicine, EUROPEAN RESUSCITATION COUNCIL, INJURY, Medicine, Humans, In patient, Neuron specific enolase (NSE), Receiver operating characteristic, business.industry, Age Factors, 030208 emergency & critical care medicine, Recovery of Function, Prognosis, Cardiac arrest, 3126 Surgery, anesthesiology, intensive care, radiology, Confidence interval, 3. Good health, Neurological outcome, Quartile, Phosphopyruvate Hydratase, MARKER, Blood Circulation, Emergency Medicine, Cardiology, OHCA, COMATOSE SURVIVORS, Cardiology and Cardiovascular Medicine, business, Out-of-Hospital Cardiac Arrest, Biomarkers, S-100B
Abstract

Aim of the study We evaluated the impact of patient age and time from collapse to return of spontaneous circulation (ROSC) on the prognostic accuracy of neuron specific enolase (NSE) after out-of-hospital cardiac arrest (OHCA). Methods Using electrochemiluminescence immunoassay, we measured serum concentrations of NSE in 249 patients who were admitted to intensive care units after resuscitation from OHCA. In each quartile according to age and time to ROSC, we evaluated the ability of NSE at 48 h after OHCA to predict poor outcome (Cerebral Performance Category 3–5) at 12 months. Results The outcome at 12 months was poor in 121 (49%) patients. The prognostic performance of NSE was excellent (area under the receiver operating characteristic curve, AUROC, 0.91 [95% confidence interval, 0.81–1.00]) in the youngest quartile (18–56 years), but worsened with increasing age, and was poor (AUROC 0.53 [0.37–0.70]) in the oldest quartile (72 years or more). The prognostic performance of NSE was worthless (AUROC 0.45 [0.30–0.61]) in the quartile with the shortest time to ROSC (1–13 min), but improved with increasing time to ROSC, and was good (AUROC 0.84 [0.74–0.95]) in the quartile with the longest time to ROSC (29 min or over). Conclusion NSE at 48 h after OHCA is a useful predictor of 12-month-prognosis in young patients and in patients with a long time from collapse to ROSC, but not in old patients or patients with a short time to ROSC.

Published
2019

37. Common Inflammation-Related Candidate Gene Variants and Acute Kidney Injury in 2647 Critically Ill Finnish Patients

Author

Vilander, Laura M., Vaara, Suvi T., Kaunisto, Mari A., Pettilä, Ville, FINNAKI Study Grp, Laru-Sompa, Raili, Pulkkinen, Anni, Saarelainen, Minna, Reilama, Mikko, Tolmunen, Sinikka, Rantalainen, Ulla, Miettinen, Marja, Suvela, Markku, Pesola, Katrine, Saastamoinen, Pekka, Kauppinen, Sirpa, Kaukonen, Kirsi-Maija, Korhonen, Anna-Maija, Nisula, Sara, Vaara, Suvi, Suojaranta-Ylinen, Raili, Mildh, Leena, Haapio, Mikko, Nurminen, Laura, Sutinen, Sari, Pettilä, Leena, Laitinen, Helinä, Syrja, Heidi, Henttonen, Kirsi, Lappi, Elina, Boman, Hillevi, Varpula, Tero, Porkka, Päivi, Sivula, Mirka, Rahkonen, Mira, Tsurkka, Anne, Prittinen, Niina, Alaspaa, Ari, Salanto, Ville, Juntunen, Hanna, Sanisalo, Teija, Parviainen, Ilkka, Uusaro, Ari, Ruokonen, Esko, Bendel, Stepani, Rissanen, Niina, Lång, Maarit, Rahikainen, Sari, Rissanen, Saija, Ahonen, Merja, Halonen, Elina, Vaskelainen, Eija, Poukkanen, Meri, Lintula, Esa, Suominen, Sirpa, Heikkinen, Jorma, Lavander, Timo, Heinonen, Kirsi, Juopperi, Anne-Mari, Kaminski, Tadeusz, Gäddnäs, Fiia, Kuusela, Tuija, Roiko, Jane, Karlsson, Sari, Reinikainen, Matti, Surakka, Tero, Jyrkönen, Helena, Eiserbeck, Tanja, Kallinen, Jaana, Lund, Vesa, Tuominen, Päivi, Perkola, Pauliina, Tuominen, Riikka, Hietaranta, Marika, Johansson, Satu, Hovilehto, Seppo, Kirsi, Anne, Tiainen, Pekka, Myllärinen, Tuija, Leino, Pirjo, Toropainen, Anne, Kuitunen, Anne, Leppänen, Ilona, Levoranta, Markus, Hoppu, Sanna, Sauranen, Jukka, Tenhunen, Jyrki, Kukkurainen, Atte, Kortelainen, Samuli, Varila, Simo, Inkinen, Outi, Koivuviita, Niina, Kotamäki, Jutta, Laine, Anu, Ala-Kokko, Tero, Laurila, Jouko J., Sälkiö, Sinikka, Koivisto, Simo-Pekka, Hautamäki, Raku, Skinnar, Maria, Anestesiologian yksikkö, Clinicum, Department of Diagnostics and Therapeutics, University of Helsinki, HUS Perioperative, Intensive Care and Pain Medicine, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Nefrologian yksikkö, Department of Medicine, HUS Abdominal Center, and HYKS erva

Subjects
medicine.medical_specialty, Candidate gene, ADVERSE OUTCOMES, lcsh:Medicine, human genetics, Genome-wide association study, Article, PROMOTER POLYMORPHISM, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Genetic model, Genetic predisposition, medicine, GENOME-WIDE ASSOCIATION, PLASMA-LEVELS, 030304 developmental biology, 0303 health sciences, SEPSIS, business.industry, MORTALITY, lcsh:R, Acute kidney injury, 1184 Genetics, developmental biology, physiology, NECROSIS-FACTOR-ALPHA, General Medicine, Odds ratio, medicine.disease, INTERLEUKIN-10, 3. Good health, acute kidney injury, 030220 oncology & carcinogenesis, 3121 General medicine, internal medicine and other clinical medicine, Cohort, genetic variation, ENDOTHELIAL GROWTH-FACTOR, RISK-FACTORS, business, Kidney disease
Abstract

Acute kidney injury (AKI) is a syndrome with high incidence among the critically ill. Because the clinical variables and currently used biomarkers have failed to predict the individual susceptibility to AKI, candidate gene variants for the trait have been studied. Studies about genetic predisposition to AKI have been mainly underpowered and of moderate quality. We report the association study of 27 genetic variants in a cohort of Finnish critically ill patients, focusing on the replication of associations detected with variants in genes related to inflammation, cell survival, or circulation. In this prospective, observational Finnish Acute Kidney Injury (FINNAKI) study, 2647 patients without chronic kidney disease were genotyped. We defined AKI according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria. We compared severe AKI (Stages 2 and 3, n = 625) to controls (Stage 0, n = 1582). For genotyping we used iPLEXTM Assay (Agena Bioscience). We performed the association analyses with PLINK software, using an additive genetic model in logistic regression. Despite the numerous, although contradictory, studies about association between polymorphisms rs1800629 in TNFA and rs1800896 in IL10 and AKI, we found no association (odds ratios 1.06 (95% CI 0.89–1.28, p = 0.51) and 0.92 (95% CI 0.80–1.05, p = 0.20), respectively). Adjusting for confounders did not change the results. To conclude, we could not confirm the associations reported in previous studies in a cohort of critically ill patients.

Published
2019

40. Urine NGAL as a biomarker for septic AKI: a critical appraisal of clinical utility—data from the observational FINNAKI study.

Author

Törnblom, Sanna, Nisula, Sara, Petäjä, Liisa, Vaara, Suvi T., Haapio, Mikko, Pesonen, Eero, Pettilä, Ville, the FINNAKI study group, Laru-Sompa, Raili, Pulkkinen, Anni, Saarelainen, Minna, Reilama, Mikko, Tolmunen, Sinikka, Rantalainen, Ulla, Miettinen, Marja, Suvela, Markku, Pesola, Katrine, Saastamoinen, Pekka, Kauppinen, Sirpa, and Kaukonen, Kirsi-Maija

Subjects
RECEIVER operating characteristic curves, INTENSIVE care patients, ACUTE kidney failure, URINE
Abstract

Background: Neutrophil gelatinase-associated lipocalin (NGAL) is released from kidney tubular cells under stress as well as from neutrophils during inflammation. It has been suggested as a biomarker for acute kidney injury (AKI) in critically ill patients with sepsis. To evaluate clinical usefulness of urine NGAL (uNGAL), we post-hoc applied recently introduced statistical methods to a sub-cohort of septic patients from the prospective observational Finnish Acute Kidney Injury (FINNAKI) study. Accordingly, in 484 adult intensive care unit patients with sepsis by Sepsis-3 criteria, we calculated areas under the receiver operating characteristic curves (AUCs) for the first available uNGAL to assess discrimination for four outcomes: AKI defined by Kidney Disease: Improving Global Outcomes (KDIGO) criteria, severe (KDIGO 2–3) AKI, and renal replacement therapy (RRT) during the first 3 days of intensive care, and mortality at day 90. We constructed clinical prediction models for the outcomes and used risk assessment plots and decision curve analysis with predefined threshold probabilities to test whether adding uNGAL to the models improved reclassification or decision making in clinical practice. Results: Incidences of AKI, severe AKI, RRT, and mortality were 44.8% (217/484), 27.7% (134/484), 9.5% (46/484), and 28.1% (136/484). Corresponding AUCs for uNGAL were 0.690, 0.728, 0.769, and 0.600. Adding uNGAL to the clinical prediction models improved discrimination of AKI, severe AKI, and RRT. However, the net benefits for the new models were only 1.4% (severe AKI and RRT) to 2.5% (AKI), and the number of patients needed to be tested per one extra true-positive varied from 40 (AKI) to 74 (RRT) at the predefined threshold probabilities. Conclusions: The results of the recommended new statistical methods do not support the use of uNGAL in critically ill septic patients to predict AKI or clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Time course of signaling profiles of blood leukocytes in acute pancreatitis and sepsis.

Author

Turunen, Antti, Kuuliala, Antti, Penttilä, Anne, Kaukonen, Kirsi-Maija, Mustonen, Harri, Pettilä, Ville, Puolakkainen, Pauli, Kylänpää, Leena, and Kuuliala, Krista

Subjects
SEPSIS, LEUCOCYTES, PANCREATITIS, PHOSPHORYLATION, CELLULAR signal transduction, LIPOPOLYSACCHARIDES, FLOW cytometry, HLA-B27 antigen, ENDOSCOPIC retrograde cholangiopancreatography, TIME, CASE-control method, DNA-binding proteins, CARRIER proteins, MONOCYTES
Abstract

Activation of intracellular signaling pathways in circulating leukocytes represents an early step in systemic immune-inflammatory response occurring e.g. in acute pancreatitis (AP) and sepsis. Previously, we found aberrations in the phosphorylation of leukocyte signaling proteins in patients with sepsis or AP (measured <48 h from hospital admission) resembling each other and associating with AP severity. Of these patients, those with sepsis or severe AP complicated by persistent organ dysfunction (OD+, n = 17) and patients with moderately severe AP (OD-, n = 6) were followed up in this study by measuring the phosphorylations at two additional time points (2-4 and 5-8 days after the initial sample) using phosphospecific whole blood flow cytometry. Twenty-eighty healthy subjects served as controls (HC). Constitutive STAT3 phosphorylation (pSTAT3) declined in monocytes and neutrophils of OD-/OD + and in lymphocytes of OD + and remained higher in OD- than HC. Monocytes of OD-/OD + showed low pSTAT3 and pSTAT1 levels in response to IL-6 through follow-up. Monocyte pNF-κB levels in response to TNF, LPS and E. coli in OD+, to E. coli in OD-, and lymphocyte pNF-κB levels in response to TNF in OD- increased during follow-up but remained lower than in HC, and neutrophil pNF-κB levels in response to TNF declined in OD-. Phorbol myristate acetate + Ca2+ ionophore-stimulated pERK1/2 decreased in neutrophils of OD-/OD+. To conclude, in patients with moderately severe or severe AP or sepsis, improvement and molecular events contributing to OD can be assessed at the level of blood leukocyte signaling. [ABSTRACT FROM AUTHOR]

Published
2020
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42. Erratum to: Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study

Author

Nisula, Sara, Kaukonen, Kirsi-Maija, Vaara, Suvi T., Korhonen, Anna-Maija, Poukkanen, Meri, Karlsson, Sari, Haapio, Mikko, Inkinen, Outi, Parviainen, Ilkka, Suojaranta-Ylinen, Raili, Laurila, Jouko J., Tenhunen, Jyrki, Reinikainen, Matti, Ala-Kokko, Tero, Ruokonen, Esko, Kuitunen, Anne, Pettilä, Ville, and The FINNAKI Study Group

Published
2013
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43. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

Author

Maas, Andrew I R, primary, Menon, David K, additional, Adelson, P David, additional, Andelic, Nada, additional, Bell, Michael J, additional, Belli, Antonio, additional, Bragge, Peter, additional, Brazinova, Alexandra, additional, Büki, András, additional, Chesnut, Randall M, additional, Citerio, Giuseppe, additional, Coburn, Mark, additional, Cooper, D Jamie, additional, Crowder, A Tamara, additional, Czeiter, Endre, additional, Czosnyka, Marek, additional, Diaz-Arrastia, Ramon, additional, Dreier, Jens P, additional, Duhaime, Ann-Christine, additional, Ercole, Ari, additional, van Essen, Thomas A, additional, Feigin, Valery L, additional, Gao, Guoyi, additional, Giacino, Joseph, additional, Gonzalez-Lara, Laura E, additional, Gruen, Russell L, additional, Gupta, Deepak, additional, Hartings, Jed A, additional, Hill, Sean, additional, Jiang, Ji-yao, additional, Ketharanathan, Naomi, additional, Kompanje, Erwin J O, additional, Lanyon, Linda, additional, Laureys, Steven, additional, Lecky, Fiona, additional, Levin, Harvey, additional, Lingsma, Hester F, additional, Maegele, Marc, additional, Majdan, Marek, additional, Manley, Geoffrey, additional, Marsteller, Jill, additional, Mascia, Luciana, additional, McFadyen, Charles, additional, Mondello, Stefania, additional, Newcombe, Virginia, additional, Palotie, Aarno, additional, Parizel, Paul M, additional, Peul, Wilco, additional, Piercy, James, additional, Polinder, Suzanne, additional, Puybasset, Louis, additional, Rasmussen, Todd E, additional, Rossaint, Rolf, additional, Smielewski, Peter, additional, Söderberg, Jeannette, additional, Stanworth, Simon J, additional, Stein, Murray B, additional, von Steinbüchel, Nicole, additional, Stewart, William, additional, Steyerberg, Ewout W, additional, Stocchetti, Nino, additional, Synnot, Anneliese, additional, Te Ao, Braden, additional, Tenovuo, Olli, additional, Theadom, Alice, additional, Tibboel, Dick, additional, Videtta, Walter, additional, Wang, Kevin K W, additional, Williams, W Huw, additional, Wilson, Lindsay, additional, Yaffe, Kristine, additional, Adams, Hadie, additional, Agnoletti, Vanni, additional, Allanson, Judith, additional, Amrein, Krisztina, additional, Andaluz, Norberto, additional, Anke, Audny, additional, Antoni, Anna, additional, van As, Arjan Bastiaan, additional, Audibert, Gérard, additional, Azaševac, Antun, additional, Azouvi, Philippe, additional, Azzolini, Maria Luisa, additional, Baciu, Camelia, additional, Badenes, Rafael, additional, Barlow, Karen M, additional, Bartels, Ronald, additional, Bauerfeind, Ursula, additional, Beauchamp, Miriam, additional, Beer, Darcy, additional, Beer, Ronny, additional, Belda, Francisco Javier, additional, Bellander, Bo-Michael, additional, Bellier, Rémy, additional, Benali, Habib, additional, Benard, Thierry, additional, Beqiri, Valzerda, additional, Beretta, Luigi, additional, Bernard, Francis, additional, Bertolini, Guido, additional, Bilotta, Federico, additional, Blaabjerg, Morten, additional, den Boogert, Hugo, additional, Boutis, Kathy, additional, Bouzat, Pierre, additional, Brooks, Brian, additional, Brorsson, Camilla, additional, Bullinger, Monika, additional, Burns, Emma, additional, Calappi, Emiliana, additional, Cameron, Peter, additional, Carise, Elsa, additional, Castaño-León, Ana M, additional, Causin, Francesco, additional, Chevallard, Giorgio, additional, Chieregato, Arturo, additional, Christie, Brian, additional, Cnossen, Maryse, additional, Coles, Jonathan, additional, Collett, Johnny, additional, Della Corte, Francesco, additional, Craig, William, additional, Csato, Gabor, additional, Csomos, Akos, additional, Curry, Nicola, additional, Dahyot-Fizelier, Claire, additional, Dawes, Helen, additional, DeMatteo, Carol, additional, Depreitere, Bart, additional, Dewey, Deborah, additional, van Dijck, Jeroen, additional, Đilvesi, Đula, additional, Dippel, Diederik, additional, Dizdarevic, Kemal, additional, Donoghue, Emma, additional, Duek, Or, additional, Dulière, Guy-Loup, additional, Dzeko, Adelaida, additional, Eapen, George, additional, Emery, Carolyn A, additional, English, Shane, additional, Esser, Patrick, additional, Ezer, Erzsébet, additional, Fabricius, Martin, additional, Feng, Junfeng, additional, Fergusson, Dean, additional, Figaji, Anthony, additional, Fleming, Joanne, additional, Foks, Kelly, additional, Francony, Gilles, additional, Freedman, Stephen, additional, Freo, Ulderico, additional, Frisvold, Shirin K, additional, Gagnon, Isabelle, additional, Galanaud, Damien, additional, Gantner, Dashiell, additional, Giraud, Benoit, additional, Glocker, Ben, additional, Golubovic, Jagoš, additional, Gómez López, Pedro A, additional, Gordon, Wayne A, additional, Gradisek, Primoz, additional, Gravel, Jocelyn, additional, Griesdale, Donald, additional, Grossi, Francesca, additional, Haagsma, Juanita A, additional, Håberg, Asta Kristine, additional, Haitsma, Iain, additional, Van Hecke, Wim, additional, Helbok, Raimund, additional, Helseth, Eirik, additional, van Heugten, Caroline, additional, Hoedemaekers, Cornelia, additional, Höfer, Stefan, additional, Horton, Lindsay, additional, Hui, Jiyuan, additional, Huijben, Jilske Antonia, additional, Hutchinson, Peter J, additional, Jacobs, Bram, additional, van der Jagt, Mathieu, additional, Jankowski, Stefan, additional, Janssens, Koen, additional, Jelaca, Bojan, additional, Jones, Kelly M, additional, Kamnitsas, Konstantinos, additional, Kaps, Rafael, additional, Karan, Mladen, additional, Katila, Ari, additional, Kaukonen, Kirsi-Maija, additional, De Keyser, Véronique, additional, Kivisaari, Riku, additional, Kolias, Angelos G, additional, Kolumbán, Bálint, additional, Kolundžija, Ksenija, additional, Kondziella, Daniel, additional, Koskinen, Lars-Owe, additional, Kovács, Noémi, additional, Kramer, Andreas, additional, Kutsogiannis, Demitri, additional, Kyprianou, Theodoros, additional, Lagares, Alfonso, additional, Lamontagne, François, additional, Latini, Roberto, additional, Lauzier, François, additional, Lazar, Isaac, additional, Ledig, Christian, additional, Lefering, Rolf, additional, Legrand, Valerie, additional, Levi, Leon, additional, Lightfoot, Roger, additional, Lozano, Angels, additional, MacDonald, Stephen, additional, Major, Sebastian, additional, Manara, Alex, additional, Manhes, Pauline, additional, Maréchal, Hugues, additional, Martino, Costanza, additional, Masala, Alessandro, additional, Masson, Serge, additional, Mattern, Julia, additional, McFadyen, Bradford, additional, McMahon, Catherine, additional, Meade, Maureen, additional, Melegh, Béla, additional, Menovsky, Tomas, additional, Moore, Lynne, additional, Morgado Correia, Marta, additional, Morganti-Kossmann, Maria Cristina, additional, Muehlan, Holger, additional, Mukherjee, Pratik, additional, Murray, Lynnette, additional, van der Naalt, Joukje, additional, Negru, Ancuta, additional, Nelson, David, additional, Nieboer, Daan, additional, Noirhomme, Quentin, additional, Nyirádi, József, additional, Oddo, Mauro, additional, Okonkwo, David O, additional, Oldenbeuving, Annemarie W, additional, Ortolano, Fabrizio, additional, Osmond, Martin, additional, Payen, Jean-François, additional, Perlbarg, Vincent, additional, Persona, Paolo, additional, Pichon, Nicolas, additional, Piippo-Karjalainen, Anna, additional, Pili-Floury, Sébastien, additional, Pirinen, Matti, additional, Ple, Horia, additional, Poca, Maria Antonia, additional, Posti, Jussi, additional, Van Praag, Dominique, additional, Ptito, Alain, additional, Radoi, Andreea, additional, Ragauskas, Arminas, additional, Raj, Rahul, additional, Real, Ruben G L, additional, Reed, Nick, additional, Rhodes, Jonathan, additional, Robertson, Claudia, additional, Rocka, Saulius, additional, Røe, Cecilie, additional, Røise, Olav, additional, Roks, Gerwin, additional, Rosand, Jonathan, additional, Rosenfeld, Jeffrey V, additional, Rosenlund, Christina, additional, Rosenthal, Guy, additional, Rossi, Sandra, additional, Rueckert, Daniel, additional, de Ruiter, Godard C W, additional, Sacchi, Marco, additional, Sahakian, Barbara J, additional, Sahuquillo, Juan, additional, Sakowitz, Oliver, additional, Salvato, Gerardo, additional, Sánchez-Porras, Renán, additional, Sándor, János, additional, Sangha, Grinder, additional, Schäfer, Nadine, additional, Schmidt, Silke, additional, Schneider, Kathryn J, additional, Schnyer, David, additional, Schöhl, Herbert, additional, Schoonman, Guus G, additional, Schou, Rico Frederik, additional, Sir, Özcan, additional, Skandsen, Toril, additional, Smeets, Dirk, additional, Sorinola, Abayomi, additional, Stamatakis, Emmanuel, additional, Stevanovic, Ana, additional, Stevens, Robert D, additional, Sundström, Nina, additional, Taccone, Fabio Silvio, additional, Takala, Riikka, additional, Tanskanen, Päivi, additional, Taylor, Mark Steven, additional, Telgmann, Ralph, additional, Temkin, Nancy, additional, Teodorani, Guido, additional, Thomas, Matt, additional, Tolias, Christos M, additional, Trapani, Tony, additional, Turgeon, Alexis, additional, Vajkoczy, Peter, additional, Valadka, Alex B, additional, Valeinis, Egils, additional, Vallance, Shirley, additional, Vámos, Zoltán, additional, Vargiolu, Alessia, additional, Vega, Emmanuel, additional, Verheyden, Jan, additional, Vik, Anne, additional, Vilcinis, Rimantas, additional, Vleggeert-Lankamp, Carmen, additional, Vogt, Lidia, additional, Volovici, Victor, additional, Voormolen, Daphne C, additional, Vulekovic, Peter, additional, Vande Vyvere, Thijs, additional, Van Waesberghe, Julia, additional, Wessels, Lars, additional, Wildschut, Eno, additional, Williams, Guy, additional, Winkler, Maren K L, additional, Wolf, Stefan, additional, Wood, Gordon, additional, Xirouchaki, Nektaria, additional, Younsi, Alexander, additional, Zaaroor, Menashe, additional, Zelinkova, Veronika, additional, Zemek, Roger, additional, and Zumbo, Fabrizio, additional

Published
2017
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44. Age of red cells for transfusion and outcomes in critically ill adults

Author

Cooper, D James, McQuilten, Zoe K., Nichol, Alistair, Ady, Bridget, Aubron, Cecile, Bailey, Michael, Bellomo, Rinaldo, Gantner, Dashiell, Irving, David O., Kaukonen, Kirsi-Maija, McArthur, Colin, Murray, Lynne, Pettilä, Vukke, French, Craig, TRANSFUSE Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group, Orford, Neil R., Cooper, D James, McQuilten, Zoe K., Nichol, Alistair, Ady, Bridget, Aubron, Cecile, Bailey, Michael, Bellomo, Rinaldo, Gantner, Dashiell, Irving, David O., Kaukonen, Kirsi-Maija, McArthur, Colin, Murray, Lynne, Pettilä, Vukke, French, Craig, TRANSFUSE Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group, and Orford, Neil R.

Published
2017

47. Association of oliguria with the development of acute kidney injury in the critically ill

Author

Vaara, Suvi T., primary, Parviainen, Ilkka, additional, Pettilä, Ville, additional, Nisula, Sara, additional, Inkinen, Outi, additional, Uusaro, Ari, additional, Laru-Sompa, Raili, additional, Pulkkinen, Anni, additional, Saarelainen, Minna, additional, Reilama, Mikko, additional, Tolmunen, Sinikka, additional, Rantalainen, Ulla, additional, Suvela, Markku, additional, Pesola, Katrine, additional, Saastamoinen, Pekka, additional, Kaukonen, Kirsi-Maija, additional, Korhonen, Anna-Maija, additional, Vaara, Suvi, additional, Suojaranta-Ylinen, Raili, additional, Mildh, Leena, additional, Haapio, Mikko, additional, Nurminen, Laura, additional, Sutinen, Sari, additional, Pettilä, Leena, additional, Laitinen, Helinä, additional, Syrjä, Heidi, additional, Henttonen, Kirsi, additional, Lappi, Elina, additional, Varpula, Tero, additional, Porkka, Päivi, additional, Sivula, Mirka, additional, Rahkonen, Mira, additional, Tsurkka, Anne, additional, Nieminen, Taina, additional, Alaspää, Ari, additional, Salanto, Ville, additional, Juntunen, Hanna, additional, Ruokonen, Esko, additional, Bendel, Stepani, additional, Rissanen, Niina, additional, Lång, Maarit, additional, Rahikainen, Sari, additional, Rissanen, Saija, additional, Ahonen, Merja, additional, Halonen, Elina, additional, Poukkanen, Meri, additional, Lintula, Esa, additional, Heikkinen, Jorma, additional, Lavander, Timo, additional, Heinonen, Kirsi, additional, Kaminski, Tadeusz, additional, Gäddnäs, Fiia, additional, Kuusela, Tuija, additional, Karlsson, Sari, additional, Reinikainen, Matti, additional, Surakka, Tero, additional, Jyrkönen, Helena, additional, Eiserbeck, Tanja, additional, Ala-Kokko, Tero, additional, Laurila, Jouko, additional, Lund, Vesa, additional, Tuominen, Päivi, additional, Perkola, Pauliina, additional, Tuominen, Riikka, additional, Hietaranta, Marika, additional, Hovilehto, Seppo, additional, Kirsi, Anne, additional, Tiainen, Pekka, additional, Myllärinen, Tuija, additional, Leino, Pirjo, additional, Kuitunen, Anne, additional, Tenhu-nen, Jyrki, additional, Leppänen, Ilona, additional, Levoranta, Markus, additional, Hoppu, Sanna, additional, Sauranen, Jukka, additional, Kukkurainen, Atte, additional, Kortelainen, Samuli, additional, Koivuviita, Niina, additional, Kotamäki, Jutta, additional, Koivisto, Simo-Pekka, additional, Hautamäki, Raku, additional, and Skinnar, Maria, additional

Published
2016
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48. Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort

Author

Abdul-Aziz, Mohd H., primary, Lipman, Jeffrey, additional, Akova, Murat, additional, Bassetti, Matteo, additional, De Waele, Jan J., additional, Dimopoulos, George, additional, Dulhunty, Joel, additional, Kaukonen, Kirsi-Maija, additional, Koulenti, Despoina, additional, Martin, Claude, additional, Montravers, Philippe, additional, Rello, Jordi, additional, Rhodes, Andrew, additional, Starr, Therese, additional, Wallis, Steven C., additional, and Roberts, Jason A., additional

Published
2015
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50. Predictive value of urine interleukin-18 in the evolution and outcome of acute kidney injury in critically ill adult patients

Author

Nisula, S., primary, Yang, R., additional, Poukkanen, M., additional, Vaara, S.T., additional, Kaukonen, K.M., additional, Tallgren, M., additional, Haapio, M., additional, Tenhunen, J., additional, Korhonen, A.M., additional, Pettilä, V., additional, Laru-Sompa, Raili, additional, Pulkkinen, Anni, additional, Saarelainen, Minna, additional, Reilama, Mikko, additional, Tolmunen, Sinikka, additional, Rantalainen, Ulla, additional, Miettinen, Marja, additional, Suvela, Markku, additional, Pesola, Katrine, additional, Saastamoinen, Pekka, additional, Kauppinen, Sirpa, additional, Pettilä, Ville, additional, Kaukonen, Kirsi-Maija, additional, Korhonen, Anna-Maija, additional, Nisula, Sara, additional, Vaara, Suvi, additional, Suojaranta-Ylinen, Raili, additional, Mildh, Leena, additional, Haapio, Mikko, additional, Nurminen, Laura, additional, Sutinen, Sari, additional, Pettilä, Leena, additional, Laitinen, Helinä, additional, Syrjä, Heidi, additional, Henttonen, Kirsi, additional, Lappi, Elina, additional, Boman, Hillevi, additional, Varpula, Tero, additional, Porkka, Päivi, additional, Mira Rahkonen, Mirka Sivula, additional, Tsurkka, Anne, additional, Nieminen, Taina, additional, Prittinen, Niina, additional, Alaspää, Ari, additional, Salanto, Ville, additional, Juntunen, Hanna, additional, Sanisalo, Teija, additional, Parviainen, Ilkka, additional, Uusaro, Ari, additional, Ruokonen, Esko, additional, Bendel, Stepani, additional, Rissanen, Niina, additional, Lång, Maarit, additional, Rahikainen, Sari, additional, Rissanen, Saija, additional, Ahonen, Merja, additional, Halonen, Elina, additional, Vaskelainen, Eija, additional, Poukkanen, Meri, additional, Lintula, Esa, additional, Suominen, Sirpa, additional, Heikkinen, Jorma, additional, Lavander, Timo, additional, Heinonen, Kirsi, additional, Juopperi, Anne-Mari, additional, Kaminski, Tadeusz, additional, Gäddnäs, Fiia, additional, Kuusela, Tuija, additional, Roiko, Jane, additional, Karlsson, Sari, additional, Reinikainen, Matti, additional, Surakka, Tero, additional, Jyrkönen, Helena, additional, Eiserbeck, Tanja, additional, Kallinen, Jaana, additional, Lund, Vesa, additional, Tuominen, Päivi, additional, Perkola, Pauliina, additional, Tuominen, Riikka, additional, Hietaranta, Marika, additional, Johansson, Satu, additional, Hovilehto, Seppo, additional, Kirsi, Anne, additional, Tiainen, Pekka, additional, Myllärinen, Tuija, additional, Leino, Pirjo, additional, Toropainen, Anne, additional, Kuitunen, Anne, additional, Leppänen, Ilona, additional, Levoranta, Markus, additional, Hoppu, Sanna, additional, Sauranen, Jukka, additional, Tenhunen, Jyrki, additional, Kukkurainen, Atte, additional, Kortelainen, Samuli, additional, Varila, Simo, additional, Inkinen, Outi, additional, Koivuviita, Niina, additional, Kotamäki, Jutta, additional, Laine, Anu, additional, Ala-Kokko, Tero, additional, Laurila, Jouko, additional, Sälkiö, Sinikka, additional, Koivisto, Simo-Pekka, additional, Hautamäki, Raku, additional, and Skinnar, Maria, additional

Published
2015
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