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Your search keyword '"Kaufmann, Josefin E."' showing total 5 results
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5 results on '"Kaufmann, Josefin E."'

1. Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study

Author

Yaghi, Shadi, Shu, Liqi, Mandel, Daniel, Leon Guerrero, Christopher R., Henninger, Nils, Muppa, Jayachandra, Affan, Muhammad, Ul Haq Lodhi, Omair, Heldner, Mirjam R., Antonenko, Kateryna, Seiffge, David, Arnold, Marcel, Salehi Omran, Setareh, Crandall, Ross, Lester, Evan, Lopez Mena, Diego, Arauz, Antonio, Nehme, Ahmad, Boulanger, Marion, Touze, Emmanuel, Sousa, Joao Andre, Sargento-Freitas, Joao, Barata, Vasco, Castro-Chaves, Paulo, Brito, Maria Teresa, Khan, Muhib, Mallick, Dania, Rothstein, Aaron, Khazaal, Ossama, Kaufmann, Josefin E., Engelter, Stefan T., Traenka, Christopher, Aguiar de Sousa, Diana, Soares, Mafalda, Rosa, Sara, Zhou, Lily W., Gandhi, Preet, Field, Thalia S., Mancini, Steven, Metanis, Issa, Leker, Ronen R., Pan, Kelly, Dantu, Vishnu, Baumgartner, Karl, Burton, Tina, Von Rennenberg, Regina, Nolte, Christian H., Choi, Richard, MacDonald, Jason, Bavarsad Shahripour, Reza, Guo, Xiaofan, Ghannam, Malik, Almajali, Mohammad, Samaniego, Edgar A., Sanchez, Sebastian, Rioux, Bastien, Zine-Eddine, Faycal, Poppe, Alexandre, Fonseca, Ana Catarina, Baptista, Maria Fortuna, Cruz, Diana, Romoli, Michele, De Marco, Giovanna, Longoni, Marco, Keser, Zafer, Griffin, Kim, Kuohn, Lindsey, Frontera, Jennifer, Amar, Jordan, Giles, James, Zedde, Marialuisa, Pascarella, Rosario, Grisendi, Ilaria, Nzwalo, Hipolito, Liebeskind, David S., Molaie, Amir, Cavalier, Annie, Kam, Wayneho, Mac Grory, Brian, Al Kasab, Sami, Anadani, Mohammad, Kicielinski, Kimberly, Eltatawy, Ali, Chervak, Lina, Chulluncuy-Rivas, Roberto, Aziz, Yasmin, Bakradze, Ekaterina, Tran, Thanh Lam, Rodrigo-Gisbert, Marc, Requena, Manuel, Saleh Velez, Faddi, Ortiz Gracia, Jorge, Mudassani, Varsha, de Havenon, Adam, Vishnu, Venugopalan Y., Yaddanapudi, Sridhara, Adams, Latasha, Browngoehl, Abigail, Ranasinghe, Tamra, Dunston, Randy, Lynch, Zachary, Penckofer, Mary, Siegler, James, Mayer, Silvia, Willey, Joshua, Zubair, Adeel, Cheng, Yee Kuang, Sharma, Richa, Marto, João Pedro, Mendes Ferreira, Vítor, Klein, Piers, Nguyen, Thanh N., Asad, Syed Daniyal, Sarwat, Zoha, Balabhadra, Anvesh, Patel, Shivam, Secchi, Thais, Martins, Sheila, Mantovani, Gabriel, Kim, Young Dae, Krishnaiah, Balaji, Elangovan, Cheran, Lingam, Sivani, Quereshi, Abid, Fridman, Sebastian, Alvarado, Alonso, Khasiyev, Farid, Linares, Guillermo, Mannino, Marina, Terruso, Valeria, Vassilopoulou, Sofia, Tentolouris, Vasilis, Martinez-Marino, Manuel, Carrasco Wall, Victor, Indraswari, Fransisca, El Jamal, Sleiman, Liu, Shilin, Alvi, Muhammad, Ali, Farman, Sarvath, Mohammed, Morsi, Rami Z., Kass-Hout, Tareq, Shi, Feina, Zhang, Jinhua, Sokhi, Dilraj, Said, Jamil, Simpkins, Alexis N., Gomez, Roberto, Sen, Shayak, Ghani, Mohammad, Elnazeir, Marwa, Xiao, Han, Kala, Narendra, Khan, Farhan, Stretz, Christoph, Mohammadzadeh, Nahid, Goldstein, Eric, and Furie, Karen

Published
2024
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2. Enhancement of STroke REhabilitation with Levodopa (ESTREL): Rationale and design of a randomized placebo-controlled, double blind superiority trial

Author

Zietz, Annaelle, primary, Kaufmann, Josefin E, additional, Wiesner, Karin, additional, Fischer, Sandro Kevin, additional, Wiegert, Martina, additional, Verhagen-Kamerbeek, Wilma DJ, additional, Rottenberger, Yannik, additional, Schwarz, Anne, additional, Peters, Nils, additional, Gensicke, Henrik, additional, Medlin, Friedrich, additional, Möller, Jens Carsten, additional, Bujan, Bartosz, additional, Bonati, Leo H, additional, Arnold, Marcel, additional, Schaedelin, Sabine, additional, Müri, René M., additional, Hemkens, Lars G, additional, Michel, Patrik, additional, Lyrer, Philippe A, additional, Held, Jeremia P, additional, Ford, Gary A, additional, Luft, Andreas R, additional, Traenka, Christopher, additional, and Engelter, Stefan T, additional

Published
2024
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3. Antithrombotic Treatment for Cervical Artery Dissection: A Systematic Review and Individual Patient Data Meta-Analysis.

Author

Kaufmann, Josefin E., Harshfield, Eric L., Gensicke, Henrik, Wegener, Susanne, Michel, Patrik, Kägi, Georg, Nedeltchev, Krassen, Kellert, Lars, Rosenbaum, Sverre, Nolte, Christian H., Christensen, Hanne, Arnold, Marcel, Lyrer, Philippe, Levi, Christopher, Bath, Philip M., Engelter, Stefan T., Traenka, Christopher, and Markus, Hugh S.

Published
2024
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4. Toward Individual Treatment in Cervical Artery Dissection: Subgroup Analysis of the TREAT‐CAD Randomized Trial.

Author

Kaufmann, Josefin E., Gensicke, Henrik, Schaedelin, Sabine, Luft, Andreas R., Goeggel‐Simonetti, Barbara, Fischer, Urs, Michel, Patrik, Strambo, Davide, Kägi, Georg, Vehoff, Jochen, Nedeltchev, Krassen, Kahles, Timo, Kellert, Lars, Rosenbaum, Sverre, von Rennenberg, Regina, Riegler, Christoph, Seiffge, David, Sarikaya, Hakan, Zietz, Annaelle, and Wischmann, Johannes

Subjects
*MAGNETIC resonance imaging, *RANDOMIZED controlled trials, *SUBGROUP analysis (Experimental design), *CEREBRAL ischemia, *TREATMENT delay (Medicine)
Abstract

Objective: Uncertainty remains regarding antithrombotic treatment in cervical artery dissection. This analysis aimed to explore whether certain patient profiles influence the effects of different types of antithrombotic treatment. Methods: This was a post hoc exploratory analysis based on the per‐protocol dataset from TREAT‐CAD (NCT02046460), a randomized controlled trial comparing aspirin to anticoagulation in patients with cervical artery dissection. We explored the potential effects of distinct patient profiles on outcomes in participants treated with either aspirin or anticoagulation. Profiles included (1) presenting with ischemia (no/yes), (2) occlusion of the dissected artery (no/yes), (3) early versus delayed treatment start (median), and (4) intracranial extension of the dissection (no/yes). Outcomes included clinical (stroke, major hemorrhage, death) and magnetic resonance imaging outcomes (new ischemic or hemorrhagic brain lesions) and were assessed for each subgroup in separate logistic models without adjustment for multiple testing. Results: All 173 (100%) per‐protocol participants were eligible for the analyses. Participants without occlusion had decreased odds of events when treated with anticoagulation (odds ratio [OR] = 0.28, 95% confidence interval [CI] = 0.07–0.86). This effect was more pronounced in participants presenting with cerebral ischemia (n = 118; OR = 0.16, 95% CI = 0.04–0.55). In the latter, those with early treatment (OR = 0.26, 95% CI = 0.07–0.85) or without intracranial extension of the dissection (OR = 0.34, 95% CI = 0.11–0.97) had decreased odds of events when treated with anticoagulation. Interpretation: Anticoagulation might be preferable in patients with cervical artery dissection presenting with ischemia and no occlusion or no intracranial extension of the dissection. These findings need confirmation. ANN NEUROL 2024;95:886–897 [ABSTRACT FROM AUTHOR]

Published
2024
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5. Atherosclerosis in patients with cervical artery dissection

Author

Brunner, Eveline, Kaufmann, Josefin E, Fischer, Sandro, Gensicke, Henrik, Zietz, Annaelle, Polymeris, Alexandros A, Altersberger, Valerian L, Lyrer, Philippe A, Traenka, Christopher, and Engelter, Stefan T

Abstract

Introduction: Cervical artery dissection (CeAD) is considered a non-atherosclerotic arteriopathy, but atherosclerosis of the cervical arteries may co-exist. We explored the frequency and clinical importance of co-existent atherosclerosis in patients with CeAD.Patients and methods: Single-center exploratory study from the Stroke Center Basel, Switzerland. We re-reviewed duplex ultrasound images at (i) baseline and (ii) last follow-up visit for the presence versus absence of the following atherosclerotic manifestations in the carotid arteries: (i) abnormal carotid intima-media thickness, (ii) plaques, and (iii) atherosclerotic stenosis. We investigated whether CeAD patients with versus without co-existing atherosclerosis differ regarding (a) recurrence of CeAD and (b) occurrence of vascular events (myocardial infarction, peripheral artery disease, or ischemic stroke) using logistic regression with adjustment for age and follow-up time.Results: Among 294 CeAD patients (median age 46 [IQR 37–53], 41.8% women), 35 (12%) had any atherosclerotic signs at baseline. Among 196 patients with available follow-up, another 21/196 (11%) patients developed atherosclerosis during a median follow-up of 55.7 months. Patients with atherosclerosis had decreased odds of recurrent CeADs when compared to patients without atherosclerosis (OR 0.03, 95% CI = 0.00-0.30). During follow-up, 6 (15%) vascular events occurred among 40 CeAD patients with atherosclerosis and 13 (8.5%) among 153 patients without atherosclerosis (OR 1.38, 95% CI = 0.39-4.55, data for 3 patients were missing).Discussion and conclusion: Signs of atherosclerosis in the carotid artery were detectable in 12% of CeAD patient at baseline. Additionally, 11% of CeAD patients developed new signs of atherosclerosis within the following 5 years. The presence of atherosclerosis may suggest a lower risk for recurrent CeAD. Whether it might indicate an increased risk for late clinical vascular events deserves further studies.

Published
2024
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