Search

Your search keyword '"Kaubisch, Andreas"' showing total 194 results
Start Over Author "Kaubisch, Andreas"
194 results on '"Kaubisch, Andreas"'

4. Safety, Efficacy, and Pharmacokinetics of SHR-A1811, a Human Epidermal Growth Factor Receptor 2–Directed Antibody-Drug Conjugate, in Human Epidermal Growth Factor Receptor 2–Expressing or Mutated Advanced Solid Tumors: A Global Phase I Trial.

Author

Yao, Herui, Yan, Min, Tong, Zhongsheng, Wu, Xinhong, Ryu, Min-Hee, Park, John J., Kim, Jee Hyun, Zhong, Yahua, Zhao, Yiming, Voskoboynik, Mark, Yin, Yongmei, Liu, Kan, Kaubisch, Andreas, Liu, Caigang, Zhang, Jian, Wang, Shouman, Im, Seock-Ah, Ganju, Vinod, Barve, Minal, and Li, Hui

Published
2024
Full Text
View/download PDF

7. Immunotherapy Efficacy in Advanced Hepatocellular Carcinoma in a Diverse and Underserved Population in the United States

Author

Bteich, Fernand, primary, Desai, Kush, additional, Zhang, Chenxin, additional, Kaur, Anahat, additional, Levy, Rachel, additional, Bioh, Lydia, additional, Wang, Aaron, additional, Sultana, Sharmin, additional, Kaubisch, Andreas, additional, Kinkhabwala, Milan, additional, Bellemare, Sarah, additional, Fidvi, Shabnam, additional, Kanmaniraja, Devaraju, additional, Berkenblit, Robert, additional, Moon, Jee-Young, additional, Adedimeji, Adebola, additional, Tow, Clara, additional, and Saenger, Yvonne, additional

Published
2024
Full Text
View/download PDF

8. Effect of Primary Tumor Side on Survival Outcomes in Untreated Patients With Metastatic Colorectal Cancer When Selective Internal Radiation Therapy Is Added to Chemotherapy: Combined Analysis of Two Randomized Controlled Studies

Author

Brown, Michael, Burge, Matthew, Cardaci, Giuseppe, Clarke, Stephen, Eliadis, Paul, Ferguson, Tom, Ganju, Vinod, Gibbs, Peter, van Hazel, Guy, James, Philip, Karapetis, Chris, Liauw, Winston, Marx, Gavin, Matos, Marco, Nott, Louise, Pavlakis, Nick, Powell, Alex, Price, Timothy, Ransom, David, Segelov, Eva, Shannon, Jenny, Singhal, Nimit, Strickland, Andrew, Walpole, Euan, Craninx, Michel, Delaunoit, Thierry, Deleporte, Amélie, Ferrante, Michel, Geboes, Karen, Hendlisz, Alain, Hendrickx, Koen, De Man, Marc, Monsaert, Els, Moons, Veerle, Peeters, Marc, Polus, Marc, Boucher, Eveline, Balosso, Jacques, Chevallier, Patrick, Louafi, Samy, Pracht, Marc, Rebischung, Christine, Smith, Denis, Taieb, Julien, Terrebonne, Eric, Bruch, Harald-Robert, Gehbauer, Gerald, Heinemann, Volker, Helmberger, Thomas, Ko, Yon-Dschun, Kröning, Hendrik, Lammert, Frank, Nusch, Arnd, Pluntke, Stefan, Ridwelski, Karsten, Riera-Knorrenschild, Jorge, Riess, Hanno, Riera, Jorge Ramon, Ricke, Jens, Sauerbruch, Tilmann, Scheidhauer, Klemens, Stötzer, Oliver, Tatsch, Klaus, Vehling-Kaiser, Ursula, Vogl, Thomas, Beny, Alex, Geva, Ravit, Shacham-Shmueli, Einat, Stemmer, Salomon, Tichler, Thomas, Wolf, Ido, Angelelli, Bruna, Martoni, Andrea, Findlay, Michael P.N., Isaacs, Richard, O’Donnell, Anne, Perez, David, Robinson, Bridget A., Rodríguez, Javier, Vera-Garcia, Ruth, Amin, Pradip, Bloomgarden, Daniel, Bui, James, Carlisle, James, Chai, Seungjean, Chen, Yi-Jen, Chuong, Michael, Coveler, Andrew, Facchini, Francis, Frenette, Gary, Frick, Jacob, Garofalo, Michael, George, Benjamin, Gordon, Michael, Gulec, Seza, Hannigan, James, Holtzman, Matthew, Kaubisch, Andreas, Kaiser, Adeel, Kooy, Todd, Limentani, Steven, Margolis, Jeffrey, Martin, Robert, Ozer, Howard, Padia, Siddarth, Rilling, William, Savin, Michael, Schneiderman, Elyse, Seeger, Grant, Sharma, Navesh, Shibata, Stephen, Smith, Randall, Wang, Eric, Whiting, Samuel, Aghmesheh, Morteza, Burge, Mathew, Cooray, Prasad, Feeney, Kynan, Lim, Lionel, Singh, Madhu, Underhill, Craig, Deleporte, Amelie, Durand, Aurelie, Faivre, Sandrine, Ferru, Aurelie, Hammel, Pascal, Bremer, Christoph, De Wit, Maike, Ayala, Hubert, Heching, Norman, Shani, Adi, Granetto, Cristina, Masi, Gianluca, Mosconi, Stefania, Numico, Gianmauro, Trogu, Antonio, Kim, Yeul Hong, Sae-Won, Han, Jackson, Chris, O'Donnell, Anne, Fragoso, Maria, Tan, Iain, Casado, Ana Ruiz, Liang, Jin Tung, Liu, Jin Hwang, Ades, Steven, Auber, Miklos, Boland, Patrick, Bowers, Charles, Crain, Martin, Dowling, Kyran, Iyer, Renuka, Ratner, Lynn, Sanchez, Federico, Stoltzfus, Patricia, Westcott, Mark, Sharma, Navesh K., Findlay, Michael, Robinson, Bridget, Jackson, Christopher, Gebski, Val, Van Buskirk, Mark, and Zhao, Huaqing

Published
2018
Full Text
View/download PDF

9. Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial

Author

Alistar, Angela, Asselah, Jamil, Blanc, Jean-Frederic, Borbath, Ivan, Cannon, Timothy, Chung, Ki, Cohn, Allen, Cosgrove, David P, Damjanov, Nevena, Gupta, Mukul, Karino, Yoshivasu, Karwal, Mark, Kaubisch, Andreas, Kelley, Robin, Van Laethem, Jena-Luc, Larson, Timothy, Lee, James, Li, Daneng, Manhas, Atisha, Manji, Gulam Abbas, Numata, Kazushi, Parsons, Benjamin, Paulson, Andrew S., Pinto, Carmine, Ramirez, Robert, Ratnam, Suresh, Rizell, Magnus, Rosmorduc, Olivier, Sada, Yvonne, Sasaki, Yutaka, Stal, Per I, Strasser, Simone, Trojan, Joerg, Vaccaro, Gina, Van Vlierberghe, Hans, Weiss, Alan, Weiss, Karl-Heinz, Yamashita, Tatsuya, Zhu, Andrew X, Finn, Richard S, Edeline, Julien, Cattan, Stephane, Ogasawara, Sadahisa, Palmer, Daniel, Verslype, Chris, Zagonel, Vittorina, Fartoux, Laetitia, Vogel, Arndt, Sarker, Debashis, Verset, Gontran, Chan, Stephen L, Knox, Jennifer, Daniele, Bruno, Webber, Andrea L, Ebbinghaus, Scot W, Ma, Junshui, Siegel, Abby B, Cheng, Ann-Lii, and Kudo, Masatoshi

Published
2018
Full Text
View/download PDF

13. First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials

Author

Adams, Richard, Bateman, Andrew, Blesing, Claire, Brown, Ewan, Chau, Ian, Cummins, Sebastian, Cunningham, David, Falk, Stephen, Hadaki, Maher, Hall, Marcia, Hickish, Tamas, Hornbuckle, Joanne, Lofts, Fiona, Lowndes, Sarah, Mayer, Astrid, Metcalfe, Matthew, Middleton, Gary, Mills, Jamie, Montazeri, Amir, Muirhead, Rebecca, Polychronis, Andreas, Purcell, Colin, Ross, Paul, Sharma, Ricky A, Sherwin, Liz, Smith, David, Soomal, Rubin, Swinson, Daniel, Walther, Axel, Wasan, Harpreet, Weaver, Andrew, Wilson, Charles, Wilson, Greg, Amin, Pradip, Angelelli, Bruna, Balosso, Jacques, Beny, Alex, Bloomgarden, Daniel, Boucher, Evelyn, Brown, Michael, Bruch, Harald-Robert, Bui, James, Burge, Matthew, Cardaci, Giuseppe, Carlisle, James, Chai, Seungjean, Chen, Yi-Jen, Chevallier, Patrick, Chuong, Michael, Clarke, Stephen, Coveler, Andrew, Craninx, Michael, Delanoit, Thierry, Deleporte, Amélie, Eliadis, Paul, Facchini, Francis, Ferguson, Thomas, Ferrante, Michel, Findlay, Michael, Frenette, Gary, Frick, Jacob, Ganju, Vinod, Garofalo, Michael, Geboes, Karen, Gehbauer, Gerald, George, Benjamin, Geva, Ravit, Gibbs, Peter, Gordon, Michael, Gregory, Kate, Gulec, Seza, Hannigan, James, van Hazel, Guy, Heching, Norman, Heinemann, Volker, Helmberger, Thomas, Hendlisz, Alain, Hendrickx, Koen, Holtzman, Matthew, Isaacs, Richard, Jackson, Christopher, James, Philip, Kaiser, Adeel, Karapetis, Chris, Kaubisch, Andreas, Ko, Yon-Dschun, Kröning, Hendrik, Lammert, Frank, Liauw, Winston, Limentani, Steven, Louafi, Samy, de Man, Marc, Margolis, Jeffrey, Martin, Robert, Martoni, Andrea, Marx, Gavin, Matos, Marco, Monsaert, Els, Moons, Veerle, Nott, Louise, Nusch, Arnd, O'Donnell, Anne, Ozer, Howard, Padia, Siddarth, Pavlakis, Nick, Peeters, Marc, Perez, David, Pluntke, Stefan, Polus, Marc, Powell, Alex, Pracht, Marc, Price, Timothy, Ransom, David, Rebischung, Christine, Ricke, Jens, Ridwelski, Karsten, Riera-Knorrenschild, Jorge, Riess, Hanno, Rilling, William, Robinson, Bridget, Rodríguez, Javier, Sanchez, Federico, Sauerbruch, Tilmann, Savin, Michael, Scheidhauer, Klemens, Schneiderman, Elyse, Seeger, Grant, Segelov, Eva, Schmueli, Einat Shaham, Shani, Adi, Shannon, Jenny, Sharma, Navesh, Shibata, Stephen, Singhal, Nimit, Smith, Denis, Smith, Randall, Stemmer, Salomon, Stötzer, Oliver, Strickland, Andrew, Taieb, Julien, Tatsch, Klaus, Terrebonne, Eric, Tichler, Thomas, Vehling-Kaiser, Ursula, Vera-Garcia, Ruth, Vogl, Thomas, Walpole, Euan, Wang, Eric, Whiting, Samuel, Wolf, Ido, Ades, Steven, Aghmesheh, Morteza, Auber, Miklos, Ayala, Hubert, Boland, Patrick, Bouche, Eveline, Bowers, Charles, Bremer, Christoph, Burge, Mathew, Casado, Ana Ruiz, Cooray, Prasad, Crain, Martin, De Wit, Maike, Dowling, Kyran, Durand, Aurelie, Faivre, Sandrine, Feeney, Kynan, Ferguson, Tom, Ferru, Aurelie, Fragoso, Maria, Granetto, Cristina, Hammel, Pascal, Issacs, Richard, Iyer, Renuka, Kim, Yeul Hong, Liang, Jin Tung, Lim, Lionel, Liu, Jin Hwang, Masi, Gianluca, Mosconi, Stefania, Numico, Gianmauro, Ratner, Lynn, Sae-Won, Han, Singh, Madhu, Stoltzfus, Patricia, Tan, Iain, Trogu, Antonio, Underhill, Craig, Westcott, Mark, Wasan, Harpreet S, Sharma, Navesh K, Francis, Anne, Moschandreas, Joanna, Virdee, Pradeep S, Dutton, Peter, Love, Sharon, Gebski, Val, and Gray, Alastair

Published
2017
Full Text
View/download PDF

15. A phase II study of bevacizumab and temsirolimus in advanced extra-pancreatic neuroendocrine tumors

Author

Abuzakhm, Sonia M, primary, Sukrithan, Vineeth, additional, Fruth, Briant, additional, Qin, Rui, additional, Strosberg, Jonathan, additional, Hobday, Timothy J, additional, Semrad, Thomas, additional, Reidy-Lagunes, Diane, additional, Kindler, Hedy Lee, additional, Kim, George P, additional, Knox, Jennifer J, additional, Kaubisch, Andreas, additional, Villalona-Calero, Miguel, additional, Chen, Helen, additional, Erlichman, Charles, additional, and Shah, Manisha H, additional

Published
2023
Full Text
View/download PDF

17. Outcomes of Helicobacter pylori (HP) infection in esophageal cancer (EC): A 5-year nationwide analysis.

Author

Vikash, Sindhu, primary, Vikash, Fnu, additional, Mehta, Ansh, additional, Bteich, Fernand, additional, Al Hamed, Rama, additional, Neupane, Karun, additional, Bazarbachi, Abdul-Hamid, additional, Hammami, M Bakri, additional, Esagian, Stepan M., additional, Narvel, Hiba, additional, Atalla, Eleftheria, additional, Vegivinti, Charan Thej Reddy, additional, Gor, Rajvi, additional, Shah, Nishi, additional, Shastri, Aditi, additional, Steidl, Ulrich G, additional, Verma, Amit, additional, Sica, Alejandro R., additional, Kaubisch, Andreas, additional, and Goel, Sanjay, additional

Published
2023
Full Text
View/download PDF

19. 932 Immunotherapy efficacy and tolerability in advanced hepatocellular carcinoma (HCC) in a diverse and underserved population in the United States – Importance of baseline liver function and screening

Author

Bteich, Fernand, primary, Desai, Kush, additional, Zhang, Chenxin, additional, Mcguckin, Charlotte, additional, Yan, John, additional, Sultana, Sharmin, additional, Leung, Lawrence, additional, Kaubisch, Andreas, additional, Kinkhabwala, Milan, additional, Bellemare, Sarah, additional, Adedimeji, Adebola, additional, Tow, Clara, additional, and Saenger, Yvonne, additional

Published
2022
Full Text
View/download PDF

24. Supplemental Material - Induction Chemotherapy With FOLFIRINOX Followed by Chemoradiation With Gemcitabine in Patients With Borderline-Resectable Pancreatic Ductal Adenocarcinoma

Author

Acuna-Villaorduna, Ana, Shankar, Viswanathan, Wysota, Michael, Jirgal, Amanda, Kabarriti, Rafi, Bellemare, Sarah, Goldman, Inessa, Kaubisch, Andreas, Aparo, Santiago, Goel, Sanjay, and Chuy, Jennifer

Subjects
FOS: Clinical medicine, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental Material for Induction Chemotherapy With FOLFIRINOX Followed by Chemoradiation With Gemcitabine in Patients With Borderline-Resectable Pancreatic Ductal Adenocarcinoma by Ana Acuna-Villaorduna, Viswanathan Shankar, Michael Wysota, Amanda Jirgal, Rafi Kabarriti, Sarah Bellemare, Inessa Goldman, Andreas Kaubisch, Santiago Aparo, Sanjay Goel and Jennifer Chuy in Cancer Control

Published
2022
Full Text
View/download PDF

26. Hepatocellular Carcinoma in HIV-Infected Patients: Clinical Presentation and Outcomes in a Racially Diverse Urban Population.

Author

D'Aiello, Angelica, Rahman, Numa, Patrik Brodin, N., Dave, Manish, Jasra, Sakshi, Kaubisch, Andreas, Kabarriti, Rafi, and Chuy, Jennifer

Abstract

Purpose: As life expectancy for HIV patients improve, hepatocellular carcinoma (HCC) has become a non-AIDS defining illness with a high impact on morbidity and mortality of HIV-infected individuals. We sought to compare outcomes in HIV- versus non-HIV-infected patients treated for HCC at a multiethnic academic medical health system. Methods: A retrospective chart review of patients diagnosed with HCC from 1/1/2005 to 12/31/2016 was performed. Differences in characteristics among HIV and non-HIV subjects were assessed. Associations between HIV status, viral load, CD4 count, and overall survival (OS) were also assessed. Results: We identified 915 subjects (842 non-HIV and 73 with HIV). HIV-infected subjects were younger, predominantly male non-Hispanic Blacks, and more likely to have HBV and HCV co-infection, and alcohol use at diagnosis compared to non-HIV counterparts. Stage, MELD score, Child–Pugh, and ECOG performance status were similar. HIV-positive patients received systemic therapy at significantly higher rates and liver transplantation for HCC at significantly lower rates than those without HIV. The actuarial 3- and 5-year overall survival (OS) for all patients was 48.3% and 39.4%. For HIV-infected subjects, 3- and 5-year OS was significantly worse at 36.8% and 28.3% compared to 49.3% and 40.4%, respectively, for non-HIV subjects (log rank p = 0.033). Conclusions: HIV-infected HCC patients have lower survival rates compared to those without HIV. Despite younger age and similar stage, MELD, and ECOG at diagnosis, HIV portends worse outcomes in patients with HCC. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

27. Induction Chemotherapy With FOLFIRINOX Followed by Chemoradiation With Gemcitabine in Patients With Borderline-Resectable Pancreatic Ductal Adenocarcinoma

Author

Acuna-Villaorduna, Ana, primary, Shankar, Viswanathan, additional, Wysota, Michael, additional, Jirgal, Amanda, additional, Kabarriti, Rafi, additional, Bellemare, Sarah, additional, Goldman, Inessa, additional, Kaubisch, Andreas, additional, Aparo, Santiago, additional, Goel, Sanjay, additional, and Chuy, Jennifer, additional

Published
2022
Full Text
View/download PDF

28. Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

Author

Wang, Hongwei, Venkatesh, Madhukumar, Li, Hao, Goetz, Regina, Mukherjee, Subhajit, Biswas, Arunima, Zhu, Liang, Kaubisch, Andreas, Wang, Lei, Pullman, James, Whitney, Kathleen, Kuro-o, Makoto, Roig, Andres I., Shay, Jerry W., Mohammadi, Moosa, and Mani, Sridhar

Subjects
Drug therapy, Physiological aspects, Research, Health aspects, Cell receptors -- Physiological aspects -- Research, Colon cancer -- Health aspects -- Drug therapy -- Research, Fibroblast growth factors -- Physiological aspects -- Research, Chemotherapy -- Health aspects, Cancer -- Chemotherapy
Abstract

Introduction Decades of clinical research in patients with solid tumors have demonstrated that complete and durable tumor regressions are rare. Indeed the clinical experience with chemotherapy for most solid tumor [...], The nuclear receptor pregnane X receptor (PXR) is activated by a range of xenochemicals, including chemotherapeutic drugs, and has been suggested to play a role in the development of tumor cell resistance to anticancer drugs. PXR also has been implicated as a regulator of the growth and apoptosis of colon tumors. Here, we have used a xenograft model of colon cancer to define a molecular mechanism that might underlie PXR-driven colon tumor growth and malignancy. Activation of PXR was found to be sufficient to enhance the neoplastic characteristics, including cell growth, invasion, and metastasis, of both human colon tumor cell lines and primary human colon cancer tissue xenografted into immunodeficient mice. Furthermore, we were able to show that this PXR-mediated phenotype required FGF19 signaling. PXR bound to the FGF19 promoter in both human colon tumor cells and 'normal' intestinal crypt cells. However, while both cell types proliferated in response to PXR ligands, the FGF19 promoter was activated by PXR only in cancer cells. Taken together, these data indicate that colon cancer growth in the presence of a specific PXR ligand results from tumor-specific induction of FGF19. These observations may lead to improved therapeutic regimens for colon carcinomas

Published
2011
Full Text
View/download PDF

35. Association of Addition of Ablative Therapy Following Transarterial Chemoembolization With Survival Rates in Patients With Hepatocellular Carcinoma

Author

English, Keara, primary, Brodin, N. Patrik, additional, Shankar, Viswanathan, additional, Zhu, Shaoyu, additional, Ohri, Nitin, additional, Golowa, Yosef S., additional, Cynamon, Jacob, additional, Bellemare, Sarah, additional, Kaubisch, Andreas, additional, Kinkhabwala, Milan, additional, Kalnicki, Shalom, additional, Garg, Madhur K., additional, Guha, Chandan, additional, and Kabarriti, Rafi, additional

Published
2020
Full Text
View/download PDF

40. Assessment of Treatment With Sorafenib Plus Doxorubicin vs Sorafenib Alone in Patients With Advanced Hepatocellular Carcinoma

Author

Abou-Alfa, Ghassan K., primary, Shi, Qian, additional, Knox, Jennifer J., additional, Kaubisch, Andreas, additional, Niedzwiecki, Donna, additional, Posey, James, additional, Tan, Benjamin R., additional, Kavan, Petr, additional, Goel, Rakesh, additional, Lammers, Philip E., additional, Bekaii-Saab, Tanios S., additional, Tam, Vincent C., additional, Rajdev, Lakshmi, additional, Kelley, Robin K., additional, El Dika, Imane, additional, Zemla, Tyler, additional, Potaracke, Ryan I., additional, Balletti, Jennifer, additional, El-Khoueiry, Anthony B., additional, Harding, James J., additional, Suga, Jennifer M., additional, Schwartz, Lawrence H., additional, Goldberg, Richard M., additional, Bertagnolli, Monica M., additional, Meyerhardt, Jeffrey, additional, O’Reilly, Eileen M., additional, and Venook, Alan P., additional

Published
2019
Full Text
View/download PDF

42. Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin

Author

Rao, Devika, primary, Mallick, Atrayee Basu, additional, Augustine, Titto, additional, Daroqui, Cecilia, additional, Jiffry, Jeeshan, additional, Merla, Amartej, additional, Chaudhary, Imran, additional, Seetharam, Raviraja, additional, Sood, Arjun, additional, Gajavelli, Srikanth, additional, Aparo, Santiago, additional, Rajdev, Lakshmi, additional, Kaubisch, Andreas, additional, Chuy, Jennifer, additional, Negassa, Abdissa, additional, Mariadason, John M., additional, Maitra, Radhashree, additional, and Goel, Sanjay, additional

Published
2019
Full Text
View/download PDF

43. Abstract 4932: Excision repair cross-complementing group-1 (ERCC1) induction and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin

Author

Rao, Devika, primary, Mallick, Atrayee Basu, additional, Augustine, Titto, additional, Daroqui, Cecilia, additional, Jiffry, Jeeshan, additional, Merla, Amartej, additional, Chaudhary, Imran, additional, Seetharaman, Raviraja, additional, Sood, Arjun, additional, Gajavelli, Srikanth, additional, Aparo, Santiago, additional, Rajdev, Lakshmi, additional, Kaubisch, Andreas, additional, Chuy, Jennifer, additional, Maitra, Radhashree, additional, and Goel, Sanjay, additional

Published
2019
Full Text
View/download PDF

46. Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin.

Author

Rao, Devika, Mallick, Atrayee Basu, Augustine, Titto, Daroqui, Cecilia, Jiffry, Jeeshan, Merla, Amartej, Chaudhary, Imran, Seetharam, Raviraja, Sood, Arjun, Gajavelli, Srikanth, Aparo, Santiago, Rajdev, Lakshmi, Kaubisch, Andreas, Chuy, Jennifer, Negassa, Abdissa, Mariadason, John M., Maitra, Radhashree, Goel, Sanjay, Rao, Devika, Mallick, Atrayee Basu, Augustine, Titto, Daroqui, Cecilia, Jiffry, Jeeshan, Merla, Amartej, Chaudhary, Imran, Seetharam, Raviraja, Sood, Arjun, Gajavelli, Srikanth, Aparo, Santiago, Rajdev, Lakshmi, Kaubisch, Andreas, Chuy, Jennifer, Negassa, Abdissa, Mariadason, John M., Maitra, Radhashree, and Goel, Sanjay

Abstract

Background: ERCC1, a component of nucleotide excision repair pathway, is known to repair DNA breaks induced by platinum drugs. We sought to ascertain if ERCC1 expression dynamics and a single nucleotide polymorphism (SNP) rs11615 are biomarkers of sensitivity to oxaliplatin therapy in patients with colorectal cancer (CRC). Methods: Western blot and qPCR for ERCC1 expression was performed from PBMCs isolated from patients receiving oxaliplatin-based therapy at specified timepoints. DNA was also isolated from 59 biorepository specimens for SNP analysis. Clinical benefit was determined using progression free survival (PFS) for metastatic CRC. Results: ERCC1 was induced in PBMC in response to oxaliplatin in 13/25 patients with mCRC (52%). Median PFS with ERCC1 induction was 190d compared to 237d in non-induced patients (HR 2.35, CI 1.005-5.479; p=0.0182). Conclusions: ERCC1 was induced in a sub-population of patients undergoing oxaliplatin treatment, which was associated with poorer outcome, suggesting this could serve as a marker of oxaliplatin response. C/C or C/T genotype in ERCC1 rs11615 locus decreased benefit from oxaliplatin.

Published
2019

47. Radiation Recall Dermatitis in Patients Treated with Sorafenib

Author

Mehta, Keyur, Kaubisch, Andreas, Tang, Justin, Pirlamarla, Aneesh, and Kalnicki, Shalom

Subjects
Article Subject
Abstract

Introduction. Radiation recall dermatitis (RRD) is a phenomenon that occurs in previously irradiated areas shortly after administration of a chemotherapeutic agent. As the use of sorafenib expands, the incidence of radiation recall dermatitis induced by sorafenib will likely increase. Here, we report on a patient who developed RRD and describe his clinical characteristics along with a review of the literature. Case Presentation. Our patient was treated with palliative radiation therapy (RT) to a painful metastatic hepatocellular carcinoma lesion in the right forearm. He completed his radiation course with grade 1 dermatitis, which had resolved by the time he was started on sorafenib 400 mg twice daily 7 days afterwards. On the 21st day after RT, he presented with desquamation and erythema in the previously irradiated area of the right forearm, consistent with RRD. The sorafenib was discontinued and his symptoms subsequently resolved with conservative topical management. Conclusions. Although the pathophysiologic mechanism of sorafenib-related radiation recall dermatitis remains to be investigated, practitioners should be aware of its presence and management in order to improve clinical outcomes.

Published
2018
Full Text
View/download PDF

48. Excision repair cross-complementing group-1 (ERCC1) gene induction in peripheral blood mononuclear cells as a marker of outcome in patients with colorectal cancer treated with oxaliplatin.

Author

Rao, Devika, primary, Basu Mallick, Atrayee, additional, Merla, Amartej, additional, Jiffry, Jeeshan, additional, Chaudhary, Imran, additional, Augustine, Titto A, additional, Rajdev, Lakshmi, additional, Kaubisch, Andreas, additional, Maitra, Radhashree, additional, and Goel, Sanjay, additional

Published
2019
Full Text
View/download PDF

49. Effect of Primary Tumor Side on Survival Outcomes in Untreated Patients With Metastatic Colorectal Cancer When Selective Internal Radiation Therapy Is Added to Chemotherapy: Combined Analysis of Two Randomized Controlled Studies

Author

Gibbs, Peter, primary, Heinemann, Volker, additional, Sharma, Navesh K., additional, Taieb, Julien, additional, Ricke, Jens, additional, Peeters, Marc, additional, Findlay, Michael, additional, Robinson, Bridget, additional, Jackson, Christopher, additional, Strickland, Andrew, additional, Gebski, Val, additional, Van Buskirk, Mark, additional, Zhao, Huaqing, additional, van Hazel, Guy, additional, Brown, Michael, additional, Burge, Matthew, additional, Cardaci, Giuseppe, additional, Clarke, Stephen, additional, Eliadis, Paul, additional, Ferguson, Tom, additional, Ganju, Vinod, additional, Gibbs, Peter, additional, James, Philip, additional, Karapetis, Chris, additional, Liauw, Winston, additional, Marx, Gavin, additional, Matos, Marco, additional, Nott, Louise, additional, Pavlakis, Nick, additional, Powell, Alex, additional, Price, Timothy, additional, Ransom, David, additional, Segelov, Eva, additional, Shannon, Jenny, additional, Singhal, Nimit, additional, Walpole, Euan, additional, Craninx, Michel, additional, Delaunoit, Thierry, additional, Deleporte, Amélie, additional, Ferrante, Michel, additional, Geboes, Karen, additional, Hendlisz, Alain, additional, Hendrickx, Koen, additional, De Man, Marc, additional, Monsaert, Els, additional, Moons, Veerle, additional, Polus, Marc, additional, Boucher, Eveline, additional, Balosso, Jacques, additional, Chevallier, Patrick, additional, Louafi, Samy, additional, Pracht, Marc, additional, Rebischung, Christine, additional, Smith, Denis, additional, Terrebonne, Eric, additional, Bruch, Harald-Robert, additional, Gehbauer, Gerald, additional, Helmberger, Thomas, additional, Ko, Yon-Dschun, additional, Kröning, Hendrik, additional, Lammert, Frank, additional, Nusch, Arnd, additional, Pluntke, Stefan, additional, Ridwelski, Karsten, additional, Riera-Knorrenschild, Jorge, additional, Riess, Hanno, additional, Riera, Jorge Ramon, additional, Sauerbruch, Tilmann, additional, Scheidhauer, Klemens, additional, Stötzer, Oliver, additional, Tatsch, Klaus, additional, Vehling-Kaiser, Ursula, additional, Vogl, Thomas, additional, Beny, Alex, additional, Geva, Ravit, additional, Shacham-Shmueli, Einat, additional, Stemmer, Salomon, additional, Tichler, Thomas, additional, Wolf, Ido, additional, Angelelli, Bruna, additional, Martoni, Andrea, additional, Findlay, Michael P.N., additional, Isaacs, Richard, additional, O’Donnell, Anne, additional, Perez, David, additional, Robinson, Bridget A., additional, Rodríguez, Javier, additional, Vera-Garcia, Ruth, additional, Amin, Pradip, additional, Bloomgarden, Daniel, additional, Bui, James, additional, Carlisle, James, additional, Chai, Seungjean, additional, Chen, Yi-Jen, additional, Chuong, Michael, additional, Coveler, Andrew, additional, Facchini, Francis, additional, Frenette, Gary, additional, Frick, Jacob, additional, Garofalo, Michael, additional, George, Benjamin, additional, Gordon, Michael, additional, Gulec, Seza, additional, Hannigan, James, additional, Holtzman, Matthew, additional, Kaubisch, Andreas, additional, Kaiser, Adeel, additional, Kooy, Todd, additional, Limentani, Steven, additional, Margolis, Jeffrey, additional, Martin, Robert, additional, Ozer, Howard, additional, Padia, Siddarth, additional, Rilling, William, additional, Savin, Michael, additional, Schneiderman, Elyse, additional, Seeger, Grant, additional, Sharma, Navesh, additional, Shibata, Stephen, additional, Smith, Randall, additional, Wang, Eric, additional, Whiting, Samuel, additional, Aghmesheh, Morteza, additional, Burge, Mathew, additional, Cooray, Prasad, additional, Feeney, Kynan, additional, Lim, Lionel, additional, Singh, Madhu, additional, Underhill, Craig, additional, Deleporte, Amelie, additional, Durand, Aurelie, additional, Faivre, Sandrine, additional, Ferru, Aurelie, additional, Hammel, Pascal, additional, Bremer, Christoph, additional, De Wit, Maike, additional, Ayala, Hubert, additional, Heching, Norman, additional, Shani, Adi, additional, Granetto, Cristina, additional, Masi, Gianluca, additional, Mosconi, Stefania, additional, Numico, Gianmauro, additional, Trogu, Antonio, additional, Kim, Yeul Hong, additional, Sae-Won, Han, additional, Jackson, Chris, additional, O'Donnell, Anne, additional, Fragoso, Maria, additional, Tan, Iain, additional, Casado, Ana Ruiz, additional, Liang, Jin Tung, additional, Liu, Jin Hwang, additional, Ades, Steven, additional, Auber, Miklos, additional, Boland, Patrick, additional, Bowers, Charles, additional, Crain, Martin, additional, Dowling, Kyran, additional, Iyer, Renuka, additional, Ratner, Lynn, additional, Sanchez, Federico, additional, Stoltzfus, Patricia, additional, and Westcott, Mark, additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results