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18 results on '"Katz, Wendy S."'

2. An obligatory role for neurotensin in high-fat-diet-induced obesity

Author

Li, Jing, Song, Jun, Zaytseva, Yekaterina Y., Liu, Yajuan, Rychahou, Piotr, Jiang, Kai, Starr, Marlene E., Kim, Ji Tae, Harris, Jennifer W., Yiannikouris, Frederique B., Katz, Wendy S., Nilsson, Peter M., Orho-Melander, Marju, Chen, Jing, Zhu, Haining, Fahrenholz, Timothy, Higashi, Richard M., Gao, Tianyan, Morris, Andrew J., Cassis, Lisa A., Fan, Teresa W.-M., Weiss, Heidi L., Dobner, Paul R., Melander, Olle, Jia, Jianhang, and Evers, B. Mark

Subjects
Ketogenic diet -- Health aspects, Obesity -- Physiological aspects, Neurotensin -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Obesity and its associated comorbidities (for example, diabetes mellitus and hepatic steatosis) contribute to approximately 2.5 million deaths annually (1) and are among the most prevalent and challenging conditions confronting [...]

Published
2016

4. Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity

Author

Araujo, Nathalia, primary, Sledziona, James, additional, Noothi, Sunil K., additional, Burikhanov, Ravshan, additional, Hebbar, Nikhil, additional, Ganguly, Saptadwipa, additional, Shrestha-Bhattarai, Tripti, additional, Zhu, Beibei, additional, Katz, Wendy S., additional, Zhang, Yi, additional, Taylor, Barry S., additional, Liu, Jinze, additional, Chen, Li, additional, Weiss, Heidi L., additional, He, Daheng, additional, Wang, Chi, additional, Morris, Andrew J., additional, Cassis, Lisa A., additional, Nikolova-Karakashian, Mariana, additional, Nagareddy, Prabhakar R., additional, Melander, Olle, additional, Evers, B. Mark, additional, Kern, Philip A., additional, and Rangnekar, Vivek M., additional

Published
2022
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6. Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates

Author

Katz, Wendy S., Hill, Russel J., Clandinin, Thomas R., and Sternberg, Paul W.

Subjects
Caenorhabditis elegans -- Research, Vulva -- Research, Biological sciences
Abstract

The epidermal growth factor-like domain of the LIN-3 protein can stimulate a 1 degree fate and a lower dose of LIN-3 stimulates a 2 degree fate. A big amount of LIN-3 can also stimulate neighbouring vulval precursor cells to attain 1 degree fates. Thus, a high degree of LIN-3 can overrule the lateral signaling that usually precludes creation of adjacent 1 degree fates. It is proposed that the unchangeable pattern of vulval cell fates is produced by a graded distribution of LIN-3 that advances various vulval fates according to local concentration and by a lateral signal strengthening the primary bias.

Published
1995

8. C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/frizzled in Wnt signaling

Author

Oz, Helieh S., Inoue, Takao, Gharib, Shahla, Deshpande, Rashmi, Wiland, Debra, Katz, Wendy S., and Sternberg, Paul W.

Subjects
Cell aggregation -- Research, Genetic regulation -- Research, Biological sciences
Abstract

Wnt proteins are intercellular signals that regulate various aspects of animal development. It is studied that two independent Wnt signaling pathways, one employing a Ryk receptor and the other Frizzled receptor, function in parallel to regulate cell fate patterning in the C. elegans vulva.

Published
2004

9. Increasing Adipocyte Lipoprotein Lipase Improves Glucose Metabolism in High Fat Diet-induced Obesity

Author

Walton, R. Grace, primary, Zhu, Beibei, additional, Unal, Resat, additional, Spencer, Michael, additional, Sunkara, Manjula, additional, Morris, Andrew J., additional, Charnigo, Richard, additional, Katz, Wendy S., additional, Daugherty, Alan, additional, Howatt, Deborah A., additional, Kern, Philip A., additional, and Finlin, Brian S., additional

Published
2015
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11. A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog

Author

Katz, Wendy S., Lesa, Giovanni M., Yannoukakos, Drakoulis, Clandinin, Thomas R., Schlessinger, Joseph, and Sternberg, Paul W.

Subjects
Caltech Library Services
Abstract

The let-23 gene encodes a Caenorhabditis elegans homolog of the epidermal growth factor receptor (EGFR) necessary for vulval development. We have characterized a mutation of let-23 that activates the receptor and downstream signal transduction, leading to excess vulval differentiation. This mutation alters a conserved cysteine residue in the extracellular domain and is the first such point mutation in the EGFR subfamily of tyrosine kinases. Mutation of a different cysteine in the same subdomain causes a strong loss-of- function phenotype, suggesting that cysteines in this region are important for function and nonequivalent. Vulval precursor cells can generate either of two subsets of vulval cells (distinct fates) in response to sa62 activity. The fates produced depended on the copy number of the mutation, suggesting that quantitative differences in receptor activity influence the decision between these two fates.

Published
1996

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