1. Target validation of G-protein coupled receptors
- Author
-
Alan Wise, Katy L. Gearing, and Stephen Rees
- Subjects
Pharmacology ,Orphan receptor ,Orphan Drug Production ,G protein ,Drug discovery ,business.industry ,Receptors, Drug ,Gene Expression ,Computational biology ,Biology ,Models, Biological ,GTP-Binding Proteins ,Drug Discovery ,Animals ,Humans ,Computer Simulation ,Pharmaceutical sciences ,Receptor ,business ,Pharmaceutical industry ,G protein-coupled receptor - Abstract
G-protein coupled receptors (GPCRs) represent possibly the most important target class of proteins for drug discovery. Over 30% of clinically marketed drugs are active at this receptor family. These drugs exhibit their activity at
- Published
- 2002