1. Effect of extracorporeal granulocytapheresis (G-1) on antigen-induced arthritis in rabbits
- Author
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Masakazu Adachi, Nobuhito Kashiwagi, Tatuo Ide, Hiromu Shibusawa, Reiji Kasukawa, Tetuzou Agishi, Shinichi Yoshino, Katuya Hiraishi, and Shoshirou Asakura
- Subjects
medicine.medical_specialty ,biology ,medicine.diagnostic_test ,business.industry ,Arthritis ,medicine.disease ,Extracorporeal ,Flow cytometry ,Ovalbumin ,Immune system ,Antigen induced arthritis ,Endocrinology ,Internal medicine ,Immunology ,medicine ,biology.protein ,Distribution (pharmacology) ,business ,Whole blood - Abstract
To investigate the role of granulocytes in arthritis, extracorporporeal granulocytapherersis (G-1) was performed using the column containing cellulose acetate beads in rabbits with immune arthritis.After injection of ovalbumin into the knee joints of ovalbumin-sensitized animals to induce joint swelling, markedly increased number of granulocytes in peripheral blood and granulocytes accumulation into the arthritic joint were shown. Approximately 18% of granulocytes in whole blood were removed by G-1. Effect of G-1 on granulocytes was investigated by flow cytometry. G-1 treated granulocytes showed a significant decrease in active oxygen production (p
- Published
- 1994
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