Search

Your search keyword '"Kattula, Deepthi"' showing total 43 results
Start Over Author "Kattula, Deepthi"
43 results on '"Kattula, Deepthi"'

3. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

Author

Aboderin, Aaron Oladipo, Al-Abri, Seif Salem, Awang Jalil, Nordiah, Benzonana, Nur, Bhattacharya, Sanjay, Brink, Adrian John, Burkert, Francesco Robert, Cars, Otto, Cornaglia, Giuseppe, Dyar, Oliver James, Friedrich, Alex W, Gales, Ana C, Gandra, Sumanth, Giske, Christian Georg, Goff, Debra A, Goossens, Herman, Gottlieb, Thomas, Guzman Blanco, Manuel, Hryniewicz, Waleria, Kattula, Deepthi, Jinks, Timothy, Kanj, Souha S, Kerr, Lawrence, Kieny, Marie-Paule, Kim, Yang Soo, Kozlov, Roman S, Labarca, Jaime, Laxminarayan, Ramanan, Leder, Karin, Leibovici, Leonard, Levy-Hara, Gabriel, Littman, Jasper, Malhotra-Kumar, Surbhi, Manchanda, Vikas, Moja, Lorenzo, Ndoye, Babacar, Pan, Angelo, Paterson, David L, Paul, Mical, Qiu, Haibo, Ramon-Pardo, Pilar, Rodríguez-Baño, Jesús, Sanguinetti, Maurizio, Sengupta, Sharmila, Sharland, Mike, Si-Mehand, Massinissa, Silver, Lynn L, Song, Wonkeung, Steinbakk, Martin, Thomsen, Jens, Thwaites, Guy E, van der Meer, Jos WM, Van Kinh, Nguyen, Vega, Silvio, Villegas, Maria Virginia, Wechsler-Fördös, Agnes, Wertheim, Heiman Frank Louis, Wesangula, Evelyn, Woodford, Neil, Yilmaz, Fidan O, Zorzet, Anna, Tacconelli, Evelina, Carrara, Elena, Savoldi, Alessia, Harbarth, Stephan, Mendelson, Marc, Monnet, Dominique L, Pulcini, Céline, Kahlmeter, Gunnar, Kluytmans, Jan, Carmeli, Yehuda, Ouellette, Marc, Outterson, Kevin, Patel, Jean, Cavaleri, Marco, Cox, Edward M, Houchens, Chris R, Grayson, M Lindsay, Hansen, Paul, Singh, Nalini, Theuretzbacher, Ursula, and Magrini, Nicola

Published
2018
Full Text
View/download PDF

4. Natural History of Cryptosporidiosis in a Birth Cohort in Southern India

Author

Kattula, Deepthi, Jeyavelu, Nithya, Prabhakaran, Ashok D., Premkumar, Prasanna S., Velusamy, Vasanthakumar, Venugopal, Srinivasan, Geetha, Jayanthi C., Lazarus, Robin P., Das, Princey, Nithyanandhan, Karthick, Gunasekaran, Chandrabose, Muliyil, Jayaprakash, Sarkar, Rajiv, Wanke, Christine, Ajjampur, Sitara Swarna Rao, Babji, Sudhir, Naumova, Elena N., Ward, Honorine D., and Kang, Gagandeep

Published
2017

10. Novel management of internal root resorption with vertical root fracture using mineral trioxide aggregate - A case report.

Author

Karumaran, Chellaswamy Savarimalai, Ramachandran, Anil Kumar, Chandrasekaran, Nirmala, Manuel, Corrine Esther, and Kattula, Deepthi

Abstract

Introduction: This case report presents the diagnosis and management of extensive internal root resorption (IRR) in a 17-year-old male patient, with a 9-year-old history of trauma.Method: The affected tooth 21 was associated with vertical root fracture (VRF) and incomplete apex closure with a substantial loss of tooth structure, including dentin and cementum. Encouraged by a healthy periodontal condition, the choice was made to use mineral trioxide aggregate (MTA) to reconstruct and reinforce the resorptive defect and the fractured segment. A composite veneer was placed to enhance the aesthetics.Result: A follow-up of the patient after 2 years revealed healing with a resolution of the lesion.Conclusion: This case report highlights the use of MTA as a lone-standing filling material for the treatment of IRR with VRF in a non-vital immature tooth. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

12. Identifying thresholds for classifying moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR

Author

Levecke, Bruno, primary, Cools, Piet, additional, Albonico, Marco, additional, Ame, Shaali, additional, Angebault, Cécile, additional, Ayana, Mio, additional, Behnke, Jerzy M., additional, Bethony, Jeffrey M., additional, Cringoli, Giuseppe, additional, Dana, Daniel, additional, Guillard, Bertrand, additional, Viet Hoa, Nguyen Thi, additional, Kang, Gagandeep, additional, Kattula, Deepthi, additional, Keiser, Jennifer, additional, Kotze, Andrew C., additional, Matoso, Leonardo F., additional, Maurelli, Maria P., additional, McCarthy, James S., additional, Mekonnen, Zeleke, additional, Mirams, Greg, additional, Montresor, Antonio, additional, Oliveira, Rodrigo Corrêa, additional, Periago, Maria V., additional, Pinto, Simone A., additional, Rinaldi, Laura, additional, Sayasone, Somphou, additional, Sumo, Laurentine, additional, Tchuem-Tchuenté, Louis-Albert, additional, Cam Thach, Dang Thi, additional, Thomas, Eurion, additional, Zeynudin, Ahmed, additional, Verweij, Jaco J., additional, Vlaminck, Johnny, additional, and Vercruysse, Jozef, additional

Published
2020
Full Text
View/download PDF

15. Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR.

Author

Levecke, Bruno, Cools, Piet, Albonico, Marco, Ame, Shaali, Angebault, Cécile, Ayana, Mio, Behnke, Jerzy M., Bethony, Jeffrey M., Cringoli, Giuseppe, Dana, Daniel, Guillard, Bertrand, Viet Hoa, Nguyen Thi, Kang, Gagandeep, Kattula, Deepthi, Keiser, Jennifer, Kotze, Andrew C., Matoso, Leonardo F., Maurelli, Maria P., McCarthy, James S., and Mekonnen, Zeleke

Subjects
HELMINTHIASIS, HOOKWORM disease, WORM eggs, ASCARIS lumbricoides, KEY performance indicators (Management), INTESTINAL infections
Abstract

World Health Organization (WHO) has defined moderate-to-heavy intensity (M&HI) infections with soil-transmitted helminths (Ascaris lumbricoides, Trichuris trichiura and the two hookworms, Ancylostoma duodenale and Necator americanus) based on specific values of eggs per gram of stool, as measured by the Kato-Katz method. There are a variety of novel microscopy and DNA-based methods but it remains unclear whether applying current WHO thresholds on to these methods allows for a reliable classification of M&HI infections. We evaluated both WHO and method-specific thresholds for classifying the M&HI infections for novel microscopic (FECPAKG2, McMaster and Mini-FLOTAC) and DNA-based (qPCR) diagnostic methods. For this, we determined method-specific thresholds that best classified M&HI infections (defined by Kato-Katz and WHO thresholds; reference method) in two multi-country drug efficacy studies. Subsequently, we verified whether applying these method-specific thresholds improved the agreement in classifying M&HI infections compared to the reference method. When we applied the WHO thresholds, the new microscopic methods mainly misclassified M&HI as low intensity, and to a lesser extent low intensity infection as M&HI. For FECPAKG2, applying the method-specific thresholds significantly improved the agreement for Ascaris (moderate → substantial), Trichuris and hookworms (fair → moderate). For Mini-FLOTAC, a significantly improved agreement was observed for hookworms only (fair → moderate). For the other STHs, the agreement was almost perfect and remained unchanged. For McMaster, the method-specific thresholds revealed a fair to a substantial agreement but did not significantly improve the agreement. For qPCR, the method-specific thresholds based on genome equivalents per ml of DNA moderately agreed with the reference method for hookworms and Trichuris infections. For Ascaris, there was a substantial agreement. We defined method-specific thresholds that improved the classification of M&HI infections. Validation studies are required before they can be recommended for general use in assessing M&HI infections in programmatic settings. Author summary: The prevalence of moderate-to-heavy intensity (M&HI) infections is a key indicator for measuring the success of large-scale deworming programs for intestinal worms because they account for the majority of the worm attributable morbidity. Currently, intestinal worm infections are classified as M&HI when the number of worm eggs that are microscopically detected in stool using a standard diagnostic method exceeds a threshold set by the World Health Organization. Over the years, a variety of new promising diagnostic methods have been introduced for the diagnosis of intestinal worms. Although they have some important advantages over the current standard method, it is not clear whether they can reliably classify M&HI infections. This is because their test results either systematically indicate lower egg counts or are expressed in a unit other than eggs per gram of stool (e.g, concentration of worm DNA), warranting the need for method-specific thresholds. We defined method-specific thresholds and verified whether they increased the correct classification of M&HI infections. Overall, our results indicate that method-specific thresholds improved the classification of M&HI infections, but that further validation is required before they can be recommended for evaluating the occurrence M&HI infections in large-scale deworming programs. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

16. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

Author

Tacconelli, Evelina, primary, Carrara, Elena, additional, Savoldi, Alessia, additional, Harbarth, Stephan, additional, Mendelson, Marc, additional, Monnet, Dominique L, additional, Pulcini, Céline, additional, Kahlmeter, Gunnar, additional, Kluytmans, Jan, additional, Carmeli, Yehuda, additional, Ouellette, Marc, additional, Outterson, Kevin, additional, Patel, Jean, additional, Cavaleri, Marco, additional, Cox, Edward M, additional, Houchens, Chris R, additional, Grayson, M Lindsay, additional, Hansen, Paul, additional, Singh, Nalini, additional, Theuretzbacher, Ursula, additional, Magrini, Nicola, additional, Aboderin, Aaron Oladipo, additional, Al-Abri, Seif Salem, additional, Awang Jalil, Nordiah, additional, Benzonana, Nur, additional, Bhattacharya, Sanjay, additional, Brink, Adrian John, additional, Burkert, Francesco Robert, additional, Cars, Otto, additional, Cornaglia, Giuseppe, additional, Dyar, Oliver James, additional, Friedrich, Alex W, additional, Gales, Ana C, additional, Gandra, Sumanth, additional, Giske, Christian Georg, additional, Goff, Debra A, additional, Goossens, Herman, additional, Gottlieb, Thomas, additional, Guzman Blanco, Manuel, additional, Hryniewicz, Waleria, additional, Kattula, Deepthi, additional, Jinks, Timothy, additional, Kanj, Souha S, additional, Kerr, Lawrence, additional, Kieny, Marie-Paule, additional, Kim, Yang Soo, additional, Kozlov, Roman S, additional, Labarca, Jaime, additional, Laxminarayan, Ramanan, additional, Leder, Karin, additional, Leibovici, Leonard, additional, Levy-Hara, Gabriel, additional, Littman, Jasper, additional, Malhotra-Kumar, Surbhi, additional, Manchanda, Vikas, additional, Moja, Lorenzo, additional, Ndoye, Babacar, additional, Pan, Angelo, additional, Paterson, David L, additional, Paul, Mical, additional, Qiu, Haibo, additional, Ramon-Pardo, Pilar, additional, Rodríguez-Baño, Jesús, additional, Sanguinetti, Maurizio, additional, Sengupta, Sharmila, additional, Sharland, Mike, additional, Si-Mehand, Massinissa, additional, Silver, Lynn L, additional, Song, Wonkeung, additional, Steinbakk, Martin, additional, Thomsen, Jens, additional, Thwaites, Guy E, additional, van der Meer, Jos WM, additional, Van Kinh, Nguyen, additional, Vega, Silvio, additional, Villegas, Maria Virginia, additional, Wechsler-Fördös, Agnes, additional, Wertheim, Heiman Frank Louis, additional, Wesangula, Evelyn, additional, Woodford, Neil, additional, Yilmaz, Fidan O, additional, and Zorzet, Anna, additional

Published
2018
Full Text
View/download PDF

17. Quantifying tap-to-household water quality deterioration in urban communities in Vellore, India: The impact of spatial assumptions

Author

Alarcon Falconi, Tania M., primary, Kulinkina, Alexandra V., additional, Mohan, Venkata Raghava, additional, Francis, Mark R., additional, Kattula, Deepthi, additional, Sarkar, Rajiv, additional, Ward, Honorine, additional, Kang, Gagandeep, additional, Balraj, Vinohar, additional, and Naumova, Elena N., additional

Published
2017
Full Text
View/download PDF

18. Natural History of Cryptosporidiosis in a Birth Cohort in Southern India

Author

Kattula, Deepthi, primary, Jeyavelu, Nithya, primary, Prabhakaran, Ashok D, primary, Premkumar, Prasanna S, primary, Velusamy, Vasanthakumar, primary, Venugopal, Srinivasan, primary, Geetha, Jayanthi C, primary, Lazarus, Robin P, primary, Das, Princey, primary, Nithyanandhan, Karthick, primary, Gunasekaran, Chandrabose, primary, Muliyil, Jayaprakash, primary, Sarkar, Rajiv, primary, Wanke, Christine, primary, Ajjampur, Sitara Swarna Rao, primary, Babji, Sudhir, primary, Naumova, Elena N, primary, Ward, Honorine D, primary, and Kang, Gagandeep, primary

Published
2016
Full Text
View/download PDF

20. Prevalence & risk factors for soil transmitted helminth infection among school children in south India

Author

Kattula, Deepthi, Sarkar, Rajiv, Ajjampur, Sitara Swarna Rao, Minz, Shantidani, Levecke, Bruno, Muliyil, Jayaprakash, and Kang, Gagandeep

Subjects
Male, UPPER EGYPT, lcsh:R, school children, Helminthiasis, lcsh:Medicine, India, risk factor analysis, CHEMOTHERAPY, EFFICACY, soil, transmitted helminths, Soil, Helminths, Prevalence, Medicine and Health Sciences, Animals, Humans, Original Article, Female, HEALTH, India - risk factor analysis - school children - soil-transmitted helminths, soil-transmitted helminths, INTESTINAL PARASITIC INFECTIONS, BEHAVIOR
Abstract

Background & objectives: Soil-transmitted helminths (STH) are a major public health problem in tropical and sub-tropical countries, affecting the physical growth and cognitive development in school-age children. This study was aimed to assess the prevalence and risk factors of STH infection among school children aged 6 -14 yr in Vellore and Thiruvanamalai districts in south India. Methods: Children aged 6-14 yr, going to government and government aided schools (n=33, randomly selected) in Vellore and Thiruvanamalai districts were screened to estimate the prevalence of STH, and a case control study was done on a subset to assess the risk factors for the infection. Results: The prevalence of STH was 7.8 per cent, varying widely in schools from 0 to 20.4 per cent, in 3706 screened children. Hookworm (8.4%) rates were high in rural areas, while Ascaris (3.3%) and Trichuris (2.2%) were more prevalent among urban children. Consumption of deworming tablets (OR=0.25, P < 0.01) offered protection, while residing in a field hut (OR=6.73, P=0.02) and unhygienic practices like open air defaecation (OR=5.37, P < 0.01), keeping untrimmed nails (OR=2.53, P=0.01) or eating food fallen on the ground (OR=2.52, P=0.01) were important risk factors for STH infection. Interpretation & conclusions: Our study indicated that school children with specific risk factors in the studied area were vulnerable subpopulation with elevated risk of STH infection. Identifying risk factors and dynamics of transmission in vulnerable groups can help to plan for effective prevention strategies.

Published
2014

24. Longitudinal Analysis of the Intestinal Microbiota in Persistently Stunted Young Children in South India

Author

Dinh, Duy M., primary, Ramadass, Balamurugan, additional, Kattula, Deepthi, additional, Sarkar, Rajiv, additional, Braunstein, Philip, additional, Tai, Albert, additional, Wanke, Christine A., additional, Hassoun, Soha, additional, Kane, Anne V., additional, Naumova, Elena N., additional, Kang, Gagandeep, additional, and Ward, Honorine D., additional

Published
2016
Full Text
View/download PDF

27. Reduction in diarrhoeal rates through interventions that prevent unnecessary antibiotic exposure early in life in an observational birth cohort

Author

Rogawski, Elizabeth T, primary, Meshnick, Steven R, additional, Becker-Dreps, Sylvia, additional, Adair, Linda S, additional, Sandler, Robert S, additional, Sarkar, Rajiv, additional, Kattula, Deepthi, additional, Ward, Honorine D, additional, Kang, Gagandeep, additional, and Westreich, Daniel J, additional

Published
2015
Full Text
View/download PDF

31. Risk Factors for Cryptosporidiosis Among Children in a Semi Urban Slum in Southern India: A Nested Case-Control Study

Author

Sarkar, Rajiv, primary, Kattula, Deepthi, additional, Jayavelu, Nithya, additional, Balraj, Vinohar, additional, Ajjampur, Sitara S. R., additional, Prabakaran, Ashok D., additional, Kang, Gagandeep, additional, Muliyil, Jayaprakash, additional, Francis, Mark R., additional, Naumova, Elena N., additional, and Ward, Honorine D., additional

Published
2014
Full Text
View/download PDF

37. Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic

Author

Vercruysse, Jozef, primary, Behnke, Jerzy M., additional, Albonico, Marco, additional, Ame, Shaali Makame, additional, Angebault, Cécile, additional, Bethony, Jeffrey M., additional, Engels, Dirk, additional, Guillard, Bertrand, additional, Hoa, Nguyen Thi Viet, additional, Kang, Gagandeep, additional, Kattula, Deepthi, additional, Kotze, Andrew C., additional, McCarthy, James S., additional, Mekonnen, Zeleke, additional, Montresor, Antonio, additional, Periago, Maria Victoria, additional, Sumo, Laurentine, additional, Tchuem Tchuenté, Louis-Albert, additional, Thach, Dang Thi Cam, additional, Zeynudin, Ahmed, additional, and Levecke, Bruno, additional

Published
2011
Full Text
View/download PDF

38. 8The first 1000 days of life: prenatal and postnatal risk factors for morbidity and growth in a birth cohort in southern India.

Author

Kattula, Deepthi, Sarkar, Rajiv, Sivarathinaswamy, Prabhu, Velusamy, Vasanthakumar, Venugopal, Srinivasan, Naumova, Elena N., Muliyil, Jayaprakash, Ward, Honorine, and Kang, Gagandeep

Abstract

Objective: To estimate the burden and assess prenatal and postnatal determinants of illnesses experienced by children residing in a semiurban slum, during the first 1000 days of life. Design: Community-based birth cohort Setting: Southern India Participants: Four hundred and ninety-seven children of 561 pregnant women recruited and followed for 2 years with surveillance and anthropometry. Main outcome measure: Incidence rates of illness; rates of clinic visits and hospitalisations; factors associated with low birth weight, various illnesses and growth. Results: Data on 10 377.7 child-months of follow-up estimated an average rate of 14.8 illnesses/child-year. Gastrointestinal and respiratory illnesses were 20.6% and 47.8% of the total disease burden, respectively. The hospitalisation rate reduced from 46/100 childyears during infancy to 19/100 child-years in the second year. Anaemia during pregnancy (OR=2.3, 95% CI=1.08 to 5.18), less than four antenatal visits (OR=6.8, 95% CI=2.1 to 22.5) and preterm birth (OR=3.3, 95% CI=1.1 to 9.7) were independent prenatal risk factors for low birth weight. Female gender (HR=0.88, 95% CI=0.79 to 0.99) and 6 months of exclusive breast feeding (HR=0.76, 95% CI=0.66 to 0.88) offered protection against all morbidity. Average monthly height and weight gain were lower in female child and children exclusively breast fed for 6 months. Conclusions: The high morbidity in Indian slum children in the first 1000 days of life was mainly due to prenatal factors and gastrointestinal and respiratory illness. Policymakers need disease prevalence and pathways to target high-risk groups with appropriate interventions in the community. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

39. Identification of Ancylostoma ceylanicum in children from a tribal community in Tamil Nadu, India using a semi-nested PCR-RFLP tool.

Author

Geldhof, Peter, Vercruysse, Jozef, Levecke, Bruno, George, Santosh, Kaliappan, Saravanakumar Puthupalayam, Kattula, Deepthi, Roy, Sheela, and Kang, Gagandeep

Subjects
ANCYLOSTOMA, NEMATODE infections, NECATOR americanus, ANCYLOSTOMA duodenale, ZOONOSES, GASTROINTESTINAL system
Abstract

Background: It is generally assumed that hookworm infections in humans are caused by Necator americanus and Ancylostoma duodenale. However, previous studies have also reported the presence of the animal hookworm A. ceylanicum in human stools. Methods: We determined hookworm infections in children in a tribal community in Tamil Nadu, India, using a semi-nested PCR-RFLP approach. Results: The results indicate that human species account for a majority of the hookworm infections (N. americanus 39/41 [95%]; A. duodenale 6/41 [15%]), whereas the animal hookworm A. ceylanicum only accounts for a minority of the infections (5%; 2/41). Conclusions: The results emphasize the need to consider zoonotic ancylostomiasis while developing strategies to control hookworm infections. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

41. The Effect of Early Life Antibiotic Exposures on Diarrheal Rates Among Young Children in Vellore, India

Author

Meshnick, Steven R., Sandler, Robert S., Kattula, Deepthi, Sarkar, Rajiv, Westreich, Daniel, Adair, Linda S., Ward, Honorine D., Kang, Gagandeep, Rogawski, Elizabeth T., and Becker-Dreps, Sylvia

Subjects
stomatognathic diseases, fluids and secretions, digestive system, 3. Good health
Abstract

Antibiotic treatment of childhood illnesses is common in India. In addition to contributing to antimicrobial resistance, antibiotics might result in increased susceptibility to diarrhea through interactions with the gastrointestinal microbiota. Breast milk, which enriches the microbiota early in life, may increase the resilience of the microbiota against perturbations by antibiotics.

42. Identification of Ancylostoma ceylanicum in children from a tribal community in Tamil Nadu, India using a semi-nested PCR-RFLP tool.

Author

George S, Kaliappan SP, Kattula D, Roy S, Geldhof P, Kang G, Vercruysse J, and Levecke B

Subjects
Ancylostoma genetics, Ancylostoma pathogenicity, Ancylostomiasis epidemiology, Ancylostomiasis prevention & control, Animals, Child, Child, Preschool, Disease Reservoirs, Dogs, Humans, India epidemiology, Molecular Sequence Data, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Species Specificity, Zoonoses epidemiology, Zoonoses parasitology, Ancylostoma isolation & purification, Ancylostomiasis diagnosis, Feces parasitology
Abstract

Background: It is generally assumed that hookworm infections in humans are caused by Necator americanus and Ancylostoma duodenale. However, previous studies have also reported the presence of the animal hookworm A. ceylanicum in human stools., Methods: We determined hookworm infections in children in a tribal community in Tamil Nadu, India, using a semi-nested PCR-RFLP approach., Results: The results indicate that human species account for a majority of the hookworm infections (N. americanus 39/41 [95%]; A. duodenale 6/41 [15%]), whereas the animal hookworm A. ceylanicum only accounts for a minority of the infections (5%; 2/41)., Conclusions: The results emphasize the need to consider zoonotic ancylostomiasis while developing strategies to control hookworm infections., (© The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2015
Full Text
View/download PDF

43. The first 1000 days of life: prenatal and postnatal risk factors for morbidity and growth in a birth cohort in southern India.

Author

Kattula D, Sarkar R, Sivarathinaswamy P, Velusamy V, Venugopal S, Naumova EN, Muliyil J, Ward H, and Kang G

Subjects
Adolescent, Adult, Child, Preschool, Female, Follow-Up Studies, Humans, India, Infant, Infant, Newborn, Male, Poverty Areas, Pregnancy, Risk Factors, Young Adult, Cost of Illness, Growth
Abstract

Objective: To estimate the burden and assess prenatal and postnatal determinants of illnesses experienced by children residing in a semiurban slum, during the first 1000 days of life., Design: Community-based birth cohort, Setting: Southern India, Participants: Four hundred and ninety-seven children of 561 pregnant women recruited and followed for 2 years with surveillance and anthropometry., Main Outcome Measure: Incidence rates of illness; rates of clinic visits and hospitalisations; factors associated with low birth weight, various illnesses and growth., Results: Data on 10 377.7 child-months of follow-up estimated an average rate of 14.8 illnesses/child-year. Gastrointestinal and respiratory illnesses were 20.6% and 47.8% of the total disease burden, respectively. The hospitalisation rate reduced from 46/100 child-years during infancy to 19/100 child-years in the second year. Anaemia during pregnancy (OR=2.3, 95% CI=1.08 to 5.18), less than four antenatal visits (OR=6.8, 95% CI=2.1 to 22.5) and preterm birth (OR=3.3, 95% CI=1.1 to 9.7) were independent prenatal risk factors for low birth weight. Female gender (HR=0.88, 95% CI=0.79 to 0.99) and 6 months of exclusive breast feeding (HR=0.76, 95% CI=0.66 to 0.88) offered protection against all morbidity. Average monthly height and weight gain were lower in female child and children exclusively breast fed for 6 months., Conclusions: The high morbidity in Indian slum children in the first 1000 days of life was mainly due to prenatal factors and gastrointestinal and respiratory illness. Policymakers need disease prevalence and pathways to target high-risk groups with appropriate interventions in the community., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results