369 results on '"Katsuhiko Kohara"'
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2. Interethnic analyses of blood pressure loci in populations of East Asian and European descent
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Fumihiko Takeuchi, Masato Akiyama, Nana Matoba, Tomohiro Katsuya, Masahiro Nakatochi, Yasuharu Tabara, Akira Narita, Woei-Yuh Saw, Sanghoon Moon, Cassandra N. Spracklen, Jin-Fang Chai, Young-Jin Kim, Liang Zhang, Chaolong Wang, Huaixing Li, Honglan Li, Jer-Yuarn Wu, Rajkumar Dorajoo, Jovia L. Nierenberg, Ya Xing Wang, Jing He, Derrick A. Bennett, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Hiromi Rakugi, Eitaro Nakashima, Masato Isono, Matsuyuki Shirota, Atsushi Hozawa, Sahoko Ichihara, Tatsuaki Matsubara, Ken Yamamoto, Katsuhiko Kohara, Michiya Igase, Sohee Han, Penny Gordon-Larsen, Wei Huang, Nanette R. Lee, Linda S. Adair, Mi Yeong Hwang, Juyoung Lee, Miao Li Chee, Charumathi Sabanayagam, Wanting Zhao, Jianjun Liu, Dermot F. Reilly, Liang Sun, Shaofeng Huo, Todd L. Edwards, Jirong Long, Li-Ching Chang, Chien-Hsiun Chen, Jian-Min Yuan, Woon-Puay Koh, Yechiel Friedlander, Tanika N. Kelly, Wen Bin Wei, Liang Xu, Hui Cai, Yong-Bing Xiang, Kuang Lin, Robert Clarke, Robin G. Walters, Iona Y. Millwood, Liming Li, John C. Chambers, Jaspal S. Kooner, Paul Elliott, Pim van der Harst, The International Genomics of Blood Pressure (iGEN-BP) Consortium, Zhengming Chen, Makoto Sasaki, Xiao-Ou Shu, Jost B. Jonas, Jiang He, Chew-Kiat Heng, Yuan-Tsong Chen, Wei Zheng, Xu Lin, Yik-Ying Teo, E-Shyong Tai, Ching-Yu Cheng, Tien Yin Wong, Xueling Sim, Karen L. Mohlke, Masayuki Yamamoto, Bong-Jo Kim, Tetsuro Miki, Toru Nabika, Mitsuhiro Yokota, Yoichiro Kamatani, Michiaki Kubo, and Norihiro Kato
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Science - Abstract
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and report ancestry-specific BP SNPs and selection signals.
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- 2018
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3. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
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Eleanor Wheeler, Aaron Leong, Ching-Ti Liu, Marie-France Hivert, Rona J Strawbridge, Clara Podmore, Man Li, Jie Yao, Xueling Sim, Jaeyoung Hong, Audrey Y Chu, Weihua Zhang, Xu Wang, Peng Chen, Nisa M Maruthur, Bianca C Porneala, Stephen J Sharp, Yucheng Jia, Edmond K Kabagambe, Li-Ching Chang, Wei-Min Chen, Cathy E Elks, Daniel S Evans, Qiao Fan, Franco Giulianini, Min Jin Go, Jouke-Jan Hottenga, Yao Hu, Anne U Jackson, Stavroula Kanoni, Young Jin Kim, Marcus E Kleber, Claes Ladenvall, Cecile Lecoeur, Sing-Hui Lim, Yingchang Lu, Anubha Mahajan, Carola Marzi, Mike A Nalls, Pau Navarro, Ilja M Nolte, Lynda M Rose, Denis V Rybin, Serena Sanna, Yuan Shi, Daniel O Stram, Fumihiko Takeuchi, Shu Pei Tan, Peter J van der Most, Jana V Van Vliet-Ostaptchouk, Andrew Wong, Loic Yengo, Wanting Zhao, Anuj Goel, Maria Teresa Martinez Larrad, Dörte Radke, Perttu Salo, Toshiko Tanaka, Erik P A van Iperen, Goncalo Abecasis, Saima Afaq, Behrooz Z Alizadeh, Alain G Bertoni, Amelie Bonnefond, Yvonne Böttcher, Erwin P Bottinger, Harry Campbell, Olga D Carlson, Chien-Hsiun Chen, Yoon Shin Cho, W Timothy Garvey, Christian Gieger, Mark O Goodarzi, Harald Grallert, Anders Hamsten, Catharina A Hartman, Christian Herder, Chao Agnes Hsiung, Jie Huang, Michiya Igase, Masato Isono, Tomohiro Katsuya, Chiea-Chuen Khor, Wieland Kiess, Katsuhiko Kohara, Peter Kovacs, Juyoung Lee, Wen-Jane Lee, Benjamin Lehne, Huaixing Li, Jianjun Liu, Stephane Lobbens, Jian'an Luan, Valeriya Lyssenko, Thomas Meitinger, Tetsuro Miki, Iva Miljkovic, Sanghoon Moon, Antonella Mulas, Gabriele Müller, Martina Müller-Nurasyid, Ramaiah Nagaraja, Matthias Nauck, James S Pankow, Ozren Polasek, Inga Prokopenko, Paula S Ramos, Laura Rasmussen-Torvik, Wolfgang Rathmann, Stephen S Rich, Neil R Robertson, Michael Roden, Ronan Roussel, Igor Rudan, Robert A Scott, William R Scott, Bengt Sennblad, David S Siscovick, Konstantin Strauch, Liang Sun, Morris Swertz, Salman M Tajuddin, Kent D Taylor, Yik-Ying Teo, Yih Chung Tham, Anke Tönjes, Nicholas J Wareham, Gonneke Willemsen, Tom Wilsgaard, Aroon D Hingorani, EPIC-CVD Consortium, EPIC-InterAct Consortium, Lifelines Cohort Study, Josephine Egan, Luigi Ferrucci, G Kees Hovingh, Antti Jula, Mika Kivimaki, Meena Kumari, Inger Njølstad, Colin N A Palmer, Manuel Serrano Ríos, Michael Stumvoll, Hugh Watkins, Tin Aung, Matthias Blüher, Michael Boehnke, Dorret I Boomsma, Stefan R Bornstein, John C Chambers, Daniel I Chasman, Yii-Der Ida Chen, Yduan-Tsong Chen, Ching-Yu Cheng, Francesco Cucca, Eco J C de Geus, Panos Deloukas, Michele K Evans, Myriam Fornage, Yechiel Friedlander, Philippe Froguel, Leif Groop, Myron D Gross, Tamara B Harris, Caroline Hayward, Chew-Kiat Heng, Erik Ingelsson, Norihiro Kato, Bong-Jo Kim, Woon-Puay Koh, Jaspal S Kooner, Antje Körner, Diana Kuh, Johanna Kuusisto, Markku Laakso, Xu Lin, Yongmei Liu, Ruth J F Loos, Patrik K E Magnusson, Winfried März, Mark I McCarthy, Albertine J Oldehinkel, Ken K Ong, Nancy L Pedersen, Mark A Pereira, Annette Peters, Paul M Ridker, Charumathi Sabanayagam, Michele Sale, Danish Saleheen, Juha Saltevo, Peter Eh Schwarz, Wayne H H Sheu, Harold Snieder, Timothy D Spector, Yasuharu Tabara, Jaakko Tuomilehto, Rob M van Dam, James G Wilson, James F Wilson, Bruce H R Wolffenbuttel, Tien Yin Wong, Jer-Yuarn Wu, Jian-Min Yuan, Alan B Zonderman, Nicole Soranzo, Xiuqing Guo, David J Roberts, Jose C Florez, Robert Sladek, Josée Dupuis, Andrew P Morris, E-Shyong Tai, Elizabeth Selvin, Jerome I Rotter, Claudia Langenberg, Inês Barroso, and James B Meigs
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Medicine - Abstract
BackgroundGlycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable by their likely biological action as erythrocytic (also associated with erythrocyte traits) or glycemic (associated with other glucose-related traits). In this study, we tested the hypotheses that, in a very large scale GWAS, we would identify more genetic variants associated with HbA1c and that HbA1c variants implicated in erythrocytic biology would affect the diagnostic accuracy of HbA1c. We therefore expanded the number of HbA1c-associated loci and tested the effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes prediction and on prevalent diabetes screening performance. Throughout this multiancestry study, we kept a focus on interancestry differences in HbA1c genetics performance that might influence race-ancestry differences in health outcomes.Methods & findingsUsing genome-wide association meta-analyses in up to 159,940 individuals from 82 cohorts of European, African, East Asian, and South Asian ancestry, we identified 60 common genetic variants associated with HbA1c. We classified variants as implicated in glycemic, erythrocytic, or unclassified biology and tested whether additive genetic scores of erythrocytic variants (GS-E) or glycemic variants (GS-G) were associated with higher T2D incidence in multiethnic longitudinal cohorts (N = 33,241). Nineteen glycemic and 22 erythrocytic variants were associated with HbA1c at genome-wide significance. GS-G was associated with higher T2D risk (incidence OR = 1.05, 95% CI 1.04-1.06, per HbA1c-raising allele, p = 3 × 10-29); whereas GS-E was not (OR = 1.00, 95% CI 0.99-1.01, p = 0.60). In Europeans and Asians, erythrocytic variants in aggregate had only modest effects on the diagnostic accuracy of HbA1c. Yet, in African Americans, the X-linked G6PD G202A variant (T-allele frequency 11%) was associated with an absolute decrease in HbA1c of 0.81%-units (95% CI 0.66-0.96) per allele in hemizygous men, and 0.68%-units (95% CI 0.38-0.97) in homozygous women. The G6PD variant may cause approximately 2% (N = 0.65 million, 95% CI 0.55-0.74) of African American adults with T2D to remain undiagnosed when screened with HbA1c. Limitations include the smaller sample sizes for non-European ancestries and the inability to classify approximately one-third of the variants. Further studies in large multiethnic cohorts with HbA1c, glycemic, and erythrocytic traits are required to better determine the biological action of the unclassified variants.ConclusionsAs G6PD deficiency can be clinically silent until illness strikes, we recommend investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G6PD deficiency is common. Screening with direct glucose measurements, or genetically-informed HbA1c diagnostic thresholds in people with G6PD deficiency, may be required to avoid missed or delayed diagnoses.
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- 2017
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4. Serum uric acid is more strongly associated with impaired fasting glucose in women than in men from a community-dwelling population.
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Ryuichi Kawamoto, Yasuharu Tabara, Katsuhiko Kohara, Tomo Kusunoki, Masanori Abe, and Tetsuro Miki
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Medicine ,Science - Abstract
Serum uric acid (SUA) levels are associated with metabolic syndrome (MetS) and its components such as glucose intolerance and type 2 diabetes. It is unknown whether there are gender-specific differences regarding the relationship between SUA levels, impaired fasting glucose (IFG) and newly detected diabetes. We recruited 1,209 men aged 60±15 (range, 19-89) years and 1,636 women aged 63±12 (range, 19-89) years during their annual health examination from a single community. We investigated the association between SUA levels and six categories according to fasting plasma glucose (FPG) level {normal fasting glucose (NFG),
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- 2013
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5. The Association between Hypertension and Dementia in the Elderly
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Michiya Igase, Katsuhiko Kohara, and Tetsuro Miki
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Hypertension (HT) and dementia are common disorders in the elderly. HT in the elderly is associated with increased occurrence rates of dementia including Alzheimer's disease (AD) and vascular dementia (VaD). In connection to this, some studies have suggested that HT in old age correlates with the pathogenesis of dementia. Since HT is potentially reversible, a number of randomized trials have examined whether antihypertensive treatment may help in preventing dementia occurrence. We review five studies, all using subjects 60 years or older, which investigated different antihypertensive pharmacological treatments. Data from two trials (Syst-Eur, PROGRESS) open the way toward the prevention of dementia (AD or VaD) by antihypertensive treatments. In the Syst-Eur study, with the dihydropyridine calcium antagonists, a reduction in both types of dementia was demonstrated (risk reduction 55%). The PROGRESS study showed that the use of angiotensin-converting enzyme inhibitors (ACEIs), with or without diuretics, resulted in decrease incidence of stroke-related dementia (risk reduction 19%), but dementia without stroke was not reduced. In contrast, the SHEP trial, treatment with a chlorthalidone-based antihypertensive regimen, did not significantly reduced the incidence of dementia. The SCOPE study (candesartan or hydrochlorothiazide versus placebo) and the HYVET-COG study (indapamide or perindopril versus placebo) found no significant difference between the active treatment and placebo group on the incidence of dementia. We found conflicting results regarding treatment benefits in dementia prevention. Recent clinical trials and studies on animal models suggest that blockades of RAS system could have reduced cognitive decline seen in Alzheimer's disease and vascular dementia. Future trials primarily designed to investigate the effects of antihypertensive agents on impaired cognition are needed.
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- 2012
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6. Leptin in sarcopenic visceral obesity: possible link between adipocytes and myocytes.
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Katsuhiko Kohara, Masayuki Ochi, Yasuharu Tabara, Tokihisa Nagai, Michiya Igase, and Tetsuro Miki
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Medicine ,Science - Abstract
The combination of sarcopenia, age-related loss of muscle strength and mass, and obesity has been recognized as a new category of obesity among the elderly. Given that leptin has been hypothesized to be involved in the pathogenesis of sarcopenic obesity, we investigated the relationship between plasma leptin levels and thigh muscle sarcopenia and visceral obesity. Thigh muscle cross-sectional area (CSA) and visceral fat area were measured using computed tomography as indices for muscle mass and visceral fat, respectively, in 782 middle-aged to elderly subjects (303 men and 479 women), participating in a medical check-up program. Visceral obesity was defined as visceral fat area >100 cm², and sarcopenia was defined as < (one standard deviation--mean of thigh muscle CSA/body weight of young subjects [aged
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- 2011
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7. A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population.
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Hiroshi Onuma, Yasuharu Tabara, Ryoichi Kawamura, Takashi Tanaka, Jun Ohashi, Wataru Nishida, Yasunori Takata, Masaaki Ochi, Kazuya Yamada, Ryuichi Kawamoto, Katsuhiko Kohara, Tetsuro Miki, Hideichi Makino, and Haruhiko Osawa
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Medicine ,Science - Abstract
Insulin resistance is a feature of type 2 diabetes. Resistin, secreted from adipocytes, causes insulin resistance in mice. We previously reported that the G/G genotype of single nucleotide polymorphism (SNP) at -420 (rs1862513) in the human resistin gene (RETN) increased susceptibility to type 2 diabetes by enhancing its promoter activity. Plasma resistin was highest in Japanese subjects with G/G genotype, followed by C/G, and C/C. In this study, we cross-sectionally analyzed plasma resistin and SNPs in the RETN region in 2,019 community-dwelling Japanese subjects. Plasma resistin was associated with SNP-638 (rs34861192), SNP-537 (rs34124816), SNP-420, SNP-358 (rs3219175), SNP+299 (rs3745367), and SNP+1263 (rs3745369) (P
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- 2010
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8. Correction: A at Single Nucleotide Polymorphism-358 Is Required for G at -420 to Confer the Highest Plasma Resistin in the General Japanese Population.
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Hiroshi Onuma, Yasuharu Tabara, Ryoichi Kawamura, Takashi Tanaka, Jun Ohashi, Wataru Nishida, Yasunori Takata, Masaaki Ochi, Kazuya Yamada, Ryuichi Kawamoto, Katsuhiko Kohara, Tetsuro Miki, Hideichi Makino, and Haruhiko Osawa
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Medicine ,Science - Published
- 2010
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9. Frequency, Intensity, and Partner of Exercise Habit Is Inversely Associated with Functional Dyspepsia in Young Japanese Population
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Yuka Saeki, Yasunori Yamamoto, Katsunori Kusumoto, Katsutoshi Okada, Shinya Furukawa, Junichi Watanabe, Yoichi Hiasa, Katsuhiko Kohara, Aki Kato, Yoshio Ikeda, Naofumi Yamamoto, Syuichi Saheki, and Eiji Takeshita
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medicine.medical_specialty ,Inverse Association ,Physiology ,Habits ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Quality of life ,Surveys and Questionnaires ,Internal medicine ,Prevalence ,medicine ,Humans ,Dyspepsia ,business.industry ,Gastroenterology ,Odds ratio ,Confidence interval ,Intensity (physics) ,030220 oncology & carcinogenesis ,Cohort ,Quality of Life ,Exercise intensity ,Etiology ,030211 gastroenterology & hepatology ,business - Abstract
Functional dyspepsia (FD) has a high prevalence worldwide and reduces patients’ quality of life. The etiology of FD is likely multifactorial. Although two studies showed an inverse association between exercise habits and FD, evidence regarding the association between exercise habits and FD remains scarce. This study aimed to investigate the association between exercise habits and FD among the young Japanese population, taking the presence or absence of an exercise partner as an additional variable. The study subjects consisted of 8923 Japanese university students. The definition of FD was based on the Rome III criteria. Information on exercise frequency, exercise intensity, and exercise partners was obtained from a self-administered questionnaire. The prevalence of FD was 1.9% in this cohort. Low, moderate, and high frequency of exercise was independently inversely associated with FD (adjusted odds ratio [OR] was low: OR 0.69 [95% confidence interval (CI) 0.47–0.997], moderate: OR 0.53 [95% CI 0.34–0.81] and high: OR 0.53 [95% CI 0.30–0.88], p for trend p = 0.002). Moderate and high intensity of exercise was independently inversely associated with FD (moderate: OR 0.56 [95% CI 0.36–0.84] and high: OR 0.49 [95% CI 0.30–0.76], p for trend p = 0.001). Exercise with groups and with friends was independently inversely associated with FD whereas the association between exercising alone and FD was not significant (groups: OR 0.28 [95% CI 0.14–0.50] and friends: OR 0.44 [95% CI 0.24–0.74]). Among the young Japanese population, frequency and intensity of exercise may be independently inversely associated with FD. Additionally, exercise with groups and with friends but not by oneself was inversely associated with exercise and FD, respectively.
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- 2021
10. Creatinine-to-cystatin C ratio as a marker of skeletal muscle mass in older adults: J-SHIPP study
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Yasuharu Tabara, Katsuhiko Kohara, Michiya Igase, Yasumasa Ohyagi, and Yoko Okada
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Male ,0301 basic medicine ,Aging ,Sarcopenia ,medicine.medical_specialty ,Community resident ,030209 endocrinology & metabolism ,Critical Care and Intensive Care Medicine ,Muscle mass ,Gastroenterology ,03 medical and health sciences ,Low muscle mass ,chemistry.chemical_compound ,0302 clinical medicine ,Japan ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Muscle Strength ,Cystatin C ,Muscle, Skeletal ,Aged ,Creatinine ,Muscle Weakness ,030109 nutrition & dietetics ,Nutrition and Dietetics ,biology ,business.industry ,Age Factors ,Middle Aged ,medicine.disease ,Skeletal muscle mass ,Cross-Sectional Studies ,Quartile ,chemistry ,Body Composition ,biology.protein ,Female ,Tomography, X-Ray Computed ,business ,Biomarkers - Abstract
Summary Background Sarcopenia increases mortality risk in older adults. Loss of skeletal muscle mass is a cardinal feature of sarcopenia. The creatinine-to-cystatin C ratio (CCR) has been suggested as a marker of muscle mass. The present study investigated the usefulness of CCR in discriminating the risk of low muscle mass and weak muscle strength in an elderly population. Methods The present cross-sectional study included 1,329 apparently healthy community residents aged 60 years or older. The cross-sectional area (CSA) of muscle in the mid-thigh was measured using computed tomography. Clinical data recorded at routine medical check-ups were obtained from each participant's medical record. Results Mean muscle CSA was 109 ± 24 cm2. CCR by quartiles according to sex was strongly associated with muscle CSA (Q1: 104 ± 22, Q2: 108 ± 24, Q3: 110 ± 23, and Q4: 114 ± 25 cm2, F = 10.38, P Conclusion CCR was a simple marker of low muscle mass and weak muscle strength in older community-dwelling adults.
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- 2020
11. Association between menstrual pain and functional dyspepsia in a Japanese young population
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Yasunori Yamamoto, Shinya Furukawa, Junichi Watanabe, Teruki Miyake, Aki Kato, Katsunori Kusumoto, Eiji Takeshita, Yoshio Ikeda, Naofumi Yamamoto, Katsuhiko Kohara, Syuichi Saheki, Yuka Saeki, and Yoichi Hiasa
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Dysmenorrhea ,Japan ,Endocrine and Autonomic Systems ,Physiology ,Gastroenterology ,Quality of Life ,Humans ,Female ,Dyspepsia ,Postprandial Period ,Abdominal Pain - Abstract
Functional dyspepsia (FD) is a very common disease worldwide. Dysmenorrhea impairs quality of life among females of reproductive age. Although dysmenorrhea is associated with irritable bowel syndrome (IBS), no study has yet evaluated the association between dysmenorrhea and FD.This study's subjects consisted of 4693 female Japanese university students. We defined FD according to the Rome III criteria. Subjects completed a self-reported questionnaire regarding menstrual irregularity, menstrual pain, and medication for menstrual pain. Age, body mass index, drinking, smoking, exercise habit, anemia, and first-year student status were selected as potential confounding factors.The prevalence of FD, epigastric pain syndrome (EPS), and postprandial distress syndrome (PDS) was 2.5%, 0.6%, and 2.1%, respectively. Heavy menstrual pain was independently positively associated with FD and PDS but not EPS (adjusted ORs: FD, 3.18 [95% CI: 1.60-6.89] and PDS, 2.93 [95% CI: 1.56-7.93] for heavy menstrual pain, p for trend = 0.001 and 0.004, respectively). Using medication for menstrual pain often was independently positively associated with FD, EPS, and PDS, respectively, (adjusted ORs: FD, 2.41 [95% CI: 1.50-3.83], EPS, 2.93 [95% CI: 1.04-7.93], PDS, 2.44 [95% CI: 1.46-4.01]). Irregular menstrual cycle was not associated with FD or with subtype of FD.Among the young female Japanese population, menstrual pain might be independently positively associated with FD and PDS but not EPS. The use of medication for menstrual pain might be independently positively associated with FD including subtype of FD.
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- 2021
12. Association Between Eating Behavior, Frequency of Meals, and Functional Dyspepsia in Young Japanese Population
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Yasunori Yamamoto, Shinya Furukawa, Junichi Watanabe, Aki Kato, Katsunori Kusumoto, Teruki Miyake, Eiji Takeshita, Yoshio Ikeda, Naofumi Yamamoto, Katsuhiko Kohara, Syuichi Saheki, Yuka Saeki, and Yoichi Hiasa
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Gastroenterology ,Neurology (clinical) - Abstract
Functional dyspepsia (FD) may be a common digestive disease worldwide and reduces the quality of life of patients. However, only a few studies have investigated the association between eating behavior and FD. The purpose of this cross-sectional study is to examine the association between eating behavior and prevalence of FD in a young Japanese cohort.In this study, we enrolled 8923 Japanese university students. FD is diagnosed based on the Rome III criteria. Eating habits and frequency of meals were investigated using a self-administered questionnaire.The FD subjects had a younger mean age, a lower body mass index, and a lower proportion of men compared to the non-FD subjects. An independent positive association between skipping breakfast and/or lunch and FD was found (adjusted ORs were 1.60 [95% CI, 1.10-2.32] for breakfast and 2.52 [95% CI, 1.04-5.18] for lunch). Skipping dinner, extra meals (snacks) or midnight snacks was not associated with FD. The prevalence of FD in subjects eating 1, 2, and 3 meals per day was 4.8%, 2.2%, and 1.7%, respectively. The frequency of meals was independently inversely associated with prevalence of FD (adjusted ORs were 1 per day: 2.72 [95% CI, 1.19-5.42], and 2 per day: 1.69 [95% CI, 1.16-2.43],In the young Japanese people, the frequency of meals may be independently inversely associated with prevalence of FD. In particular, skipping breakfast and/or lunch was associated with the prevalence of FD.
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- 2021
13. Positive Association Between Sleep Disturbance and Prevalence of Functional Dyspepsia in Japanese Young People
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Katsuhiko Kohara, Yasunori Yamamoto, Junichi Watanabe, Teruki Miyake, Yoichi Hiasa, Yuka Saeki, Katsunori Kusumoto, Eiji Takeshita, Yoshio Ikeda, Syuichi Saheki, Aki Kato, Shinya Furukawa, Naofumi Yamamoto, and Katsutoshi Okada
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Sleep Wake Disorders ,medicine.medical_specialty ,Difficulty Falling Asleep ,Adolescent ,Physiology ,Disorders of Excessive Somnolence ,Nocturnal ,Japan ,Internal medicine ,medicine ,Prevalence ,Humans ,Dyspepsia ,Association (psychology) ,Slow-wave sleep ,Sleep disorder ,business.industry ,Gastroenterology ,Syndrome ,medicine.disease ,Postprandial Period ,Sleep in non-human animals ,Abdominal Pain ,Distress ,Postprandial ,Gastritis ,business ,Sleep - Abstract
Evidence regarding the association between sleep disturbance and functional dyspepsia (FD) remains limited in the young population. This study aimed to investigate the association between sleep disturbance and FD including subgroups among Japanese young people. Study subjects were 8923 university students. FD was defined according to the Rome III criteria. Subjects with FD were further categorized as having postprandial distress syndrome (PDS) or epigastric pain syndrome (EPS). Subjects completed a self-reported questionnaire assessing self-reported sleep duration, sleep disturbance, difficulty falling asleep, deep sleep disorder, nocturnal awakening, early awakening, and daytime sleepiness. The prevalence of FD was 1.9%. After adjustment, all types of sleep disturbances were independently positively associated with FD (total sleep disturbance: OR 4.11 [95% CI: 2.89–5.78], difficulty falling asleep: OR 3.97 [95% CI: 2.53–6.01], deep sleep disorder: OR 4.85 [95% CI: 3.06–7.40], nocturnal awakening: OR 4.35 [95% CI: 1.90–8.67], early awakening: OR 4.50 [95% CI: 1.97–8.97], and daytime sleepiness: OR 2.83 [95% CI: 1.25–5.56]). While nocturnal awakening and daytime sleepiness were not associated with EPS, the other types of sleep disturbance were independently positively associated with EPS and PDS. No association between self-reported sleep duration and FD was found. Sleep disturbance may be independently positively associated with the prevalence of FD among Japanese young people. Nocturnal awakening and daytime sleepiness were not associated with EPS; the other types of sleep disturbance were independently positively associated with EPS and PDS.
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- 2021
14. Hyperglycemia in non‐obese patients with type 2 diabetes is associated with low muscle mass: The Multicenter Study for Clarifying Evidence for Sarcopenia in Patients with Diabetes Mellitus
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Tadao Tsuboyama, Kazunori Ikebe, Haruhiko Osawa, Eri Kiyoshige, Fumihiko Matsuda, Hiroshi Ikegami, Katsuhiko Kohara, Hiroshi Onuma, Yasuyuki Gondo, Yukako Makutani, Yasunori Takata, Tome Ikezoe, Mai Kabayama, Noriaki Ichihashi, Tomohiro Katsuya, Yoshihisa Hiromine, Kei Kamide, Masahiro Fukuda, Ken Sugimoto, Yasuharu Tabara, and Hiromi Rakugi
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Adult ,Male ,medicine.medical_specialty ,Sarcopenia ,Endocrinology, Diabetes and Metabolism ,Population ,Type 2 diabetes ,Diseases of the endocrine glands. Clinical endocrinology ,Body Mass Index ,chemistry.chemical_compound ,Skeletal muscle mass ,Japan ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Mass index ,education ,Glycemic ,Aged ,Aged, 80 and over ,Glycated Hemoglobin ,education.field_of_study ,business.industry ,Incidence ,General Medicine ,Odds ratio ,Articles ,Middle Aged ,medicine.disease ,RC648-665 ,Prognosis ,Clinical Science and Care ,Cross-Sectional Studies ,chemistry ,Diabetes Mellitus, Type 2 ,Hyperglycemia ,Body Composition ,Original Article ,Female ,Glycated hemoglobin ,business ,Biomarkers ,Follow-Up Studies - Abstract
Aims/Introduction Hyperglycemia is a risk factor for sarcopenia when comparing individuals with and without diabetes. However, no studies have investigated whether the findings could be extrapolated to patients with diabetes with relatively higher glycemic levels. Here, we aimed to clarify whether glycemic control was associated with sarcopenia in patients with type 2 diabetes. Materials and Methods Study participants consisted of patients with type 2 diabetes (n = 746, the average age was 69.9 years) and an older general population (n = 2,067, the average age was 68.2 years). Sarcopenia was defined as weak grip strength or slow usual gait speed and low skeletal mass index. Results Among patients with type 2 diabetes, 52 were diagnosed as having sarcopenia. The frequency of sarcopenia increased linearly with glycated hemoglobin (HbA1c) level, particularly in lean individuals (HbA1c
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- 2019
15. Steno-Stiffness Approach for Cardiovascular Disease Risk Assessment in Primary Prevention
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Mitsuru Ohishi, Tetsuo Shoji, Toshiharu Ninomiya, Toshiaki Ohkuma, Chisa Mastumoto, Yoshikuni Kita, Toyoshi Inoguchi, Yasutaka Maeda, Hirotaka Watada, Masanori Munakata, Michinari Nakamura, Takayoshi Ohkubo, Motoyuki Nakamura, Akira Yamashina, Kazuomi Kario, Norihisa Ito, Hirofumi Tomiyama, Katsuhiko Kohara, Satoshi Hoshide, Yasuharu Tabara, Victor Aboyans, Charalambos Vlachopoulos, Tohoku University [Sendai], Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), and Grelier, Elisabeth
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medicine.medical_specialty ,business.industry ,MEDLINE ,Stiffness ,030204 cardiovascular system & hematology ,Risk Assessment ,3. Good health ,Primary Prevention ,03 medical and health sciences ,Vascular Stiffness ,0302 clinical medicine ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Cardiovascular Diseases ,Risk Factors ,Primary prevention ,Internal Medicine ,medicine ,Disease risk ,Humans ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,030212 general & internal medicine ,medicine.symptom ,Intensive care medicine ,business ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2019
16. Distribution of cerebral microbleeds in the East and West
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David J. Werring, Yunyun Xiong, Sudha Seshadri, Yuki Takashima, Philip A. Wolf, Vincent Mok, Yusuke Yakushiji, Lenore J. Launer, Sarah R. Preis, Hideo Hara, Jose R. Romero, Toshio Imaizumi, Yoshito Tsushima, Alexa S. Beiser, Mark A. van Buchem, Duncan Wilson, Thanh G. Phan, Zhaolu Wang, Gareth Ambler, Charles DeCarli, Velandai Srikanth, Katsuhiko Kohara, Ding Ding, Villi Gudnason, Hyung-Min Kwon, Shuhei Yamaguchi, and Andreas Charidimou
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Male ,Distribution (number theory) ,Clinical Sciences ,Population ,Logistic regression ,Article ,Odds ,Clinical Research ,Humans ,Medicine ,education ,Cerebral Hemorrhage ,Aged ,education.field_of_study ,Neurology & Neurosurgery ,business.industry ,Individual participant data ,Neurosciences ,Correction ,Odds ratio ,Middle Aged ,Confidence interval ,Brain Disorders ,Stroke ,Geography ,Meta-analysis ,Female ,Cognitive Sciences ,Neurology (clinical) ,Medium Risk ,business ,Cartography ,Demography - Abstract
ObjectiveWe investigated differences in the anatomical distribution of cerebral microbleeds (CMBs) on MRI, hypothesized to indicate the type of underlying cerebral small vessel disease (SVD), between Eastern and Western general populations.MethodsWe analyzed data from 11 studies identified by a PubMed search between 1996 and April 2014 according to the Preferred Reporting Items for a Systematic Review and Meta-analysis of Individual Participant Data. Study quality measures indicated low or medium risk of bias. We included stroke-free participants from populations aged between 55 and 75 years, categorized by geographic location (Eastern or Western). We categorized CMB distribution (strictly lobar, deep and/or infratentorial [D/I], or mixed [i.e., CMBs located in both lobar and D/I regions]). We tested the hypothesis that Eastern and Western populations have different anatomical distributions of CMBs using multivariable mixed effects logistic regression analyses adjusted for age, sex, and hypertension and clustering by institution.ResultsAmong 8,595 stroke-free individuals (mean age [SD] 66.7 [5.6] years; 48% male; 42% from a Western population), 624 (7.3%) had CMBs (strictly lobar in 3.1%; D/I or mixed in 4.2%). In multivariable mixed effects models, Eastern populations had higher odds of D/I or mixed CMBs (adjusted odds ratio 2.78, 95% confidence interval [CI] 1.77–4.35) compared to Western populations. Eastern populations had a higher number of D/I or mixed CMBs (adjusted prevalence ratio 2.83, 95% CI 1.27–6.31).ConclusionsEastern and Western general populations have different anatomical distributions of CMBs, suggesting differences in the spectrum of predominant underlying SVDs, with potential implications for SVD diagnosis and treatment.
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- 2019
17. Association Between Body Mass Index and Functional Dyspepsia in Young Japanese People
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Yasunori Yamamoto, Shinya Furukawa, Junichi Watanabe, Aki Kato, Katsunori Kusumoto, Eiji Takeshita, Yoshio Ikeda, Naofumi Yamamoto, Katsuhiko Kohara, Yuka Saeki, and Yoichi Hiasa
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Gastroenterology ,Neurology (clinical) - Abstract
Evidence regarding the association between body mass index (BMI) and functional dyspepsia (FD) in the Asian population is limited. Further, no study has evaluated this issue in young people in Asian and Western populations. Thus, we aim to investigate this issue among young Japanese people.The study subjects comprised of 8923 Japanese university students. BMI was divided into 4 categories (quartiles) on the basis of the study subjects' distribution (lowest, low, moderate, and high [reference]). The definition of lean, normal, overweight, and obese was BMI18.5 kg/mThe prevalence of FD was 1.9% in this cohort. The lowest BMI was independently associated with FD after adjustment (adjusted odds ratio [OR], 2.88; 95% confidence interval [CI], 1.46-3.67); P for trend = 0.001). The lowest BMI was independently associated with FD in women but not in men (OR, 2.94; 95% CI, 1.59-5.77; P for trend = 0.001). Leanness was independently associated with FD in total and in women but not in men (total: adjusted OR, 2.01; 95% CI, 1.40-2.86) and women (OR, 2.19; 95% CI, 1.35-3.45). However, interaction analysis showed no significant difference for sex.Among young Japanese people, BMI may be independently inversely associated with FD. Leanness may be an independent associated factor for FD in the young Japanese women.
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- 2021
18. Association Between Eating Behavior, Frequency of Meals, and Functional Dyspepsia in Young Japanese Population.
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Yasunori Yamamoto, Shinya Furukawa, Junichi Watanabe, Aki Kato, Katsunori Kusumoto, Teruki Miyake, Eiji Takeshita, Yoshio Ikeda, Naofumi Yamamoto, Katsuhiko Kohara, Syuichi Saheki, Yuka Saeki, and Yoichi Hiasa
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FOOD habits ,JAPANESE people ,JAPANESE students ,INDIGESTION ,MEALS - Abstract
Background/Aims Functional dyspepsia (FD) may be a common digestive disease worldwide and reduces the quality of life of patients. However, only a few studies have investigated the association between eating behavior and FD. The purpose of this cross-sectional study is to examine the association between eating behavior and prevalence of FD in a young Japanese cohort. Methods In this study, we enrolled 8923 Japanese university students. FD is diagnosed based on the Rome III criteria. Eating habits and frequency of meals were investigated using a self-administered questionnaire. Results The FD subjects had a younger mean age, a lower body mass index, and a lower proportion of men compared to the non-FD subjects. An independent positive association between skipping breakfast and/or lunch and FD was found (adjusted ORs were 1.60 [95% CI, 1.10-2.32] for breakfast and 2.52 [95% CI, 1.04-5.18] for lunch). Skipping dinner, extra meals (snacks) or midnight snacks was not associated with FD. The prevalence of FD in subjects eating 1, 2, and 3 meals per day was 4.8%, 2.2%, and 1.7%, respectively. The frequency of meals was independently inversely associated with prevalence of FD (adjusted ORs were 1 per day: 2.72 [95% CI, 1.19-5.42], and 2 per day: 1.69 [95% CI, 1.16-2.43], P for trend = 0.001). Conclusions In the young Japanese people, the frequency of meals may be independently inversely associated with prevalence of FD. In particular, skipping breakfast and/or lunch was associated with the prevalence of FD. [ABSTRACT FROM AUTHOR]
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- 2022
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19. Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
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Anubha Mahajan, Cassandra N Spracklen, Weihua Zhang, Maggie CY Ng, Lauren E Petty, Hidetoshi Kitajima, Grace Z Yu, Sina Rüeger, Leo Speidel, Young Jin Kim, Momoko Horikoshi, Josep M Mercader, Daniel Taliun, Sanghoon Moon, Soo-Heon Kwak, Neil R Robertson, Nigel W Rayner, Marie Loh, Bong-Jo Kim, Joshua Chiou, Irene Miguel-Escalada, Pietro della Briotta Parolo, Kuang Lin, Fiona Bragg, Michael H Preuss, Fumihiko Takeuchi, Jana Nano, Xiuqing Guo, Amel Lamri, Masahiro Nakatochi, Robert A Scott, Jung-Jin Lee, Alicia Huerta-Chagoya, Mariaelisa Graff, Jin-Fang Chai, Esteban J Parra, Jie Yao, Lawrence F Bielak, Yasuharu Tabara, Yang Hai, Valgerdur Steinthorsdottir, James P Cook, Mart Kals, Niels Grarup, Ellen M Schmidt, Ian Pan, Tamar Sofer, Matthias Wuttke, Chloe Sarnowski, Christian Gieger, Darryl Nousome, Stella Trompet, Jirong Long, Meng Sun, Lin Tong, Wei-Min Chen, Meraj Ahmad, Raymond Noordam, Victor JY Lim, Claudia HT Tam, Yoonjung Yoonie Joo, Chien-Hsiun Chen, Laura M Raffield, Cécile Lecoeur, Nisa M Maruthur, Bram Peter Prins, Aude Nicolas, Lisa R Yanek, Guanjie Chen, Richard A Jensen, Salman Tajuddin, Edmond Kabagambe, Ping An, Anny H Xiang, Hyeok Sun Choi, Brian E Cade, Jingyi Tan, Fernando Abaitua, Linda S Adair, Adebowale Adeyemo, Carlos A Aguilar-Salinas, Masato Akiyama, Sonia S Anand, Alain Bertoni, Zheng Bian, Jette Bork-Jensen, Ivan Brandslund, Jennifer A Brody, Chad M Brummett, Thomas A Buchanan, Mickaël Canouil, Juliana CN Chan, Li-Ching Chang, Miao-Li Chee, Ji Chen, Shyh-Huei Chen, Yuan-Tsong Chen, Zhengming Chen, Lee-Ming Chuang, Mary Cushman, Swapan K Das, H. Janaka de Silva, George Dedoussis, Latchezar Dimitrov, Ayo P Doumatey, Shufa Du, Qing Duan, Kai-Uwe Eckardt, Leslie S Emery, Daniel S Evans, Michele K Evans, Krista Fischer, James S Floyd, Ian Ford, Myriam Fornage, Oscar H Franco, Timothy M Frayling, Barry I Freedman, Christian Fuchsberger, Pauline Genter, Hertzel C Gerstein, Vilmantas Giedraitis, Clicerio González-Villalpando, Maria Elena González-Villalpando, Mark O Goodarzi, Penny Gordon-Larsen, David Gorkin, Myron Gross, Yu Guo, Sophie Hackinger, Sohee Han, Andrew T Hattersley, Christian Herder, Annie-Green Howard, Willa Hsueh, Mengna Huang, Wei Huang, Yi-Jen Hung, Mi Yeong Hwang, Chii-Min Hwu, Sahoko Ichihara, Mohammad Arfan Ikram, Martin Ingelsson, Md. Tariqul Islam, Masato Isono, Hye-Mi Jang, Farzana Jasmine, Guozhi Jiang, Jost B Jonas, Marit E Jørgensen, Torben Jørgensen, Yoichiro Kamatani, Fouad R Kandeel, Anuradhani Kasturiratne, Tomohiro Katsuya, Varinderpal Kaur, Takahisa Kawaguchi, Jacob M Keaton, Abel N Kho, Chiea-Chuen Khor, Muhammad G Kibriya, Duk-Hwan Kim, Katsuhiko Kohara, Jennifer Kriebel, Florian Kronenberg, Johanna Kuusisto, Kristi Läll, Leslie A Lange, Myung-Shik Lee, Nanette R Lee, Aaron Leong, Liming Li, Yun Li, Ruifang Li-Gao, Symen Ligthart, Cecilia M Lindgren, Allan Linneberg, Ching-Ti Liu, Jianjun Liu, Adam E Locke, Tin Louie, Jian’an Luan, Andrea O Luk, Xi Luo, Jun Lv, Valeriya Lyssenko, Vasiliki Mamakou, K Radha Mani, Thomas Meitinger, Andres Metspalu, Andrew D Morris, Girish N. Nadkarni, Jerry L Nadler, Michael A Nalls, Uma Nayak, Ioanna Ntalla, Yukinori Okada, Lorena Orozco, Sanjay R Patel, Mark A Pereira, Annette Peters, Fraser J Pirie, Bianca Porneala, Gauri Prasad, Sebastian Preissl, Laura J Rasmussen-Torvik, Alexander P Reiner, Michael Roden, Rebecca Rohde, Katheryn Roll, Charumathi Sabanayagam, Maike Sander, Kevin Sandow, Naveed Sattar, Sebastian Schönherr, Claudia Schurmann, Mohammad Shahriar, Jinxiu Shi, Dong Mun Shin, Daniel Shriner, Jennifer A Smith, Wing Yee So, Alena Stančáková, Adrienne M Stilp, Konstantin Strauch, Ken Suzuki, Atsushi Takahashi, Kent D Taylor, Barbara Thorand, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Brian Tomlinson, Jason M Torres, Fuu-Jen Tsai, Jaakko Tuomilehto, Teresa Tusie-Luna, Miriam S Udler, Adan Valladares-Salgado, Rob M van Dam, Jan B van Klinken, Rohit Varma, Marijana Vujkovic, Niels Wacher-Rodarte, Ellie Wheeler, Eric A Whitsel, Ananda R Wickremasinghe, Konstantin Willems van Dijk, Daniel R Witte, Chittaranjan S Yajnik, Ken Yamamoto, Toshimasa Yamauchi, Loïc Yengo, Kyungheon Yoon, Canqing Yu, Jian-Min Yuan, Salim Yusuf, Liang Zhang, Wei Zheng, null FinnGen, Leslie J Raffel, Michiya Igase, Eli Ipp, Susan Redline, Yoon Shin Cho, Lars Lind, Michael A Province, Craig L Hanis, Patricia A Peyser, Erik Ingelsson, Alan B Zonderman, Bruce M Psaty, Ya-Xing Wang, Charles N Rotimi, Diane M Becker, Fumihiko Matsuda, Yongmei Liu, Eleftheria Zeggini, Mitsuhiro Yokota, Stephen S Rich, Charles Kooperberg, James S Pankow, James C Engert, Yii-Der Ida Chen, Philippe Froguel, James G Wilson, Wayne HH Sheu, Sharon LR Kardia, Jer-Yuarn Wu, M Geoffrey Hayes, Ronald CW Ma, Tien-Yin Wong, Leif Groop, Dennis O Mook-Kanamori, Giriraj R Chandak, Francis S Collins, Dwaipayan Bharadwaj, Guillaume Paré, Michèle M Sale, Habibul Ahsan, Ayesha A Motala, Xiao-Ou Shu, Kyong-Soo Park, J Wouter Jukema, Miguel Cruz, Roberta McKean-Cowdin, Harald Grallert, Ching-Yu Cheng, Erwin P Bottinger, Abbas Dehghan, E-Shyong Tai, Josee Dupuis, Norihiro Kato, Markku Laakso, Anna Köttgen, Woon-Puay Koh, Colin NA Palmer, Simin Liu, Goncalo Abecasis, Jaspal S Kooner, Ruth JF Loos, Kari E North, Christopher A Haiman, Jose C Florez, Danish Saleheen, Torben Hansen, Oluf Pedersen, Reedik Mägi, Claudia Langenberg, Nicholas J Wareham, Shiro Maeda, Takashi Kadowaki, Juyoung Lee, Iona Y Millwood, Robin G Walters, Kari Stefansson, Simon R Myers, Jorge Ferrer, Kyle J Gaulton, James B Meigs, Karen L Mohlke, Anna L Gloyn, Donald W Bowden, Jennifer E Below, John C Chambers, Xueling Sim, Michael Boehnke, Jerome I Rotter, Mark I McCarthy, and Andrew P Morris
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0303 health sciences ,Transferability ,Translation (biology) ,Type 2 diabetes ,Biology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Evolutionary biology ,Global health ,medicine ,Genetic risk ,Gene ,030217 neurology & neurosurgery ,030304 developmental biology ,Genetic association - Abstract
We assembled an ancestrally diverse collection of genome-wide association studies of type 2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). We identified 277 loci at genome-wide significance (p-8), including 237 attaining a more stringent trans-ancestry threshold (p-9), which were delineated to 338 distinct association signals. Trans-ancestry meta-regression offered substantial enhancements to fine-mapping, with 58.6% of associations more precisely localised due to population diversity, and 54.4% of signals resolved to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying foundations for functional investigations. Trans-ancestry genetic risk scores enhanced transferability across diverse populations, providing a step towards more effective clinical translation to improve global health.
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- 2020
20. Creatinine to Cystatin C Ratio as a Marker of Bone Property in Older Adults: The J-SHIPP Study
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Michiya Igase, Yasumasa Ohyagi, Yoko Okada, Yasuharu Tabara, and Katsuhiko Kohara
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Male ,medicine.medical_specialty ,030309 nutrition & dietetics ,Population ,Medicine (miscellaneous) ,Renal function ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Bone Density ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Cystatin C ,education ,Aged ,Bone mineral ,0303 health sciences ,education.field_of_study ,Creatinine ,Nutrition and Dietetics ,biology ,business.industry ,Skeletal muscle ,medicine.disease ,medicine.anatomical_structure ,Endocrinology ,Cross-Sectional Studies ,Quartile ,chemistry ,Sarcopenia ,biology.protein ,Female ,Geriatrics and Gerontology ,business - Abstract
To clarify whether serum creatinine to cystatin C ratio (CCR), a marker of muscle mass and muscle function may be used as a simple marker of bone property. A cross-sectional analysis. A general population-based observation study. Participants: 1,606 middle-aged to elderly (≥50 years, mean age: 66.9 ± 7.5 years old) men (n = 642) and post-menopausal women (n = 964). Speed of sound (SOS) at the calcaneal bone was used as a surrogate marker of bone mineral density. The cross-sectional area of the muscle at the mid-thigh was measured using computed tomography. There was significant linear correlation between the quartiles of CCR and SOS (Q1: 1,495 ± 25, Q2: 1,499 ± 24, Q3: 1,507 ± 26, Q4: 1,511 ± 25 m/sec; P < 0.001) even in a sex-separated analysis. This association was independent of major covariates (Q1: β = −0.126, P < 0.001; Q2: β = −0.096, P = 0.001; Q3: β = −0.022; P = 0.412, Q4: reference) and the mid-thigh muscle mass, while creatinine alone or eGFR did not show clear association with SOS. The CCR may be used as a simple marker of bone property independently of muscle mass in a general population with preserved renal function.
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- 2020
21. High central blood pressure is associated with incident cardiovascular events in treated hypertensives: the ABC-J II Study
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Kenji Takazawa, Yoshitaka Hirooka, Sadayoshi Ito, Yuhei Kawano, Kazuyuki Shimada, Hiromichi Suzuki, Yuko Ohta, Yasuaki Dohi, Akira Yamashina, Hiroshi Miyashita, Takayoshi Ohkubo, Junichiro Hashimoto, Yasuharu Tabara, Kenji Sunagawa, Kazuo Eguchi, Kazuomi Kario, Hirofumi Tomiyama, Katsuhiko Kohara, Yutaka Imai, and Tsuneo Takenaka
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Male ,medicine.medical_specialty ,Physiology ,Myocardial Infarction ,Blood Pressure ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Myocardial infarction ,Stroke ,Antihypertensive Agents ,Aged ,business.industry ,Proportional hazards model ,Incidence ,Hazard ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Aortic Dissection ,Death, Sudden, Cardiac ,Hypertension ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Body mass index ,Cohort study - Abstract
It is not established whether central blood pressure (BP) evaluated by a radial pulse wave analysis is useful to predict cardiovascular prognoses. We tested the hypothesis that central BP predicts future cardiovascular events in treated hypertensive subjects. We conducted a multicenter, observational cohort study of 3566 hypertensives being treated with antihypertensive medications at 27 institutions in Japan. We performed the radial pulse wave analyses using applanation tonometry in all subjects. The primary outcome was the incidence of any of the following: stroke, myocardial infarction (MI), sudden cardiac death, and acute aortic dissection. The mean age of the subjects was 66.0 ± 10.9 years, and 50.6% were male. The mean brachial SBP and central SBP were 138 ± 18 mm Hg and 128 ± 19 mm Hg, respectively. When the central SBP was divided into quintiles, the number of events was least in the 2nd quintile, and we set it as the reference. In the Cox regression analysis adjusting for age, sex, body mass index, creatinine, diabetes, use of β-blocker, and history of MI/stroke, the patients in the 3rd (hazard ratio (HR) 3.55, 95% confidence interval 1.29-9.78, p = 0.014), 4th (HR 4.12, 95% CI 1.53-11.10, p = 0.005), and 5th quintiles (HR 2.87, 95% CI 1.01-8.18, p = 0.048) had a significantly higher incidence of cardiovascular events compared to the 2nd quintile. The results were essentially unchanged when brachial DBP was additionally adjusted. In conclusion, in treated hypertensives, high central SBP was associated with worse cardiovascular outcomes.
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- 2018
22. Simultaneously Measured Interarm Blood Pressure Difference and Stroke
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Toshiharu Ninomiya, Hirofumi Tomiyama, Yasutaka Maeda, Katsuhiko Kohara, Motoyuki Nakamura, Toshiaki Ohkuma, Hirotaka Watada, Mitsuru Ohishi, Norihisa Ito, Akira Yamashina, Kazuomi Kario, Tetsuo Shoji, Masanori Munakata, Chisa Mastumoto, Michinari Nakamura, Charalambos Vlachopoulos, Yoshikuni Kita, Satoshi Hoshide, Yasuharu Tabara, Takayoshi Ohkubo, and Toyoshi Inoguchi
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medicine.medical_specialty ,business.industry ,Individual participant data ,Blood Pressure ,Blood Pressure Determination ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Blood pressure ,Physical medicine and rehabilitation ,medicine.anatomical_structure ,Risk Factors ,Meta-analysis ,Primary prevention ,Hypertension ,Internal Medicine ,medicine ,Humans ,Ankle Brachial Index ,030212 general & internal medicine ,Ankle ,Risk assessment ,business ,Stroke - Abstract
We conducted individual participant data meta-analysis to examine the validity of interarm blood pressure difference in simultaneous measurement as a marker to identify subjects with ankle-brachial pressure index 5 mm Hg as being associated with a significant odds ratio for the presence of ankle-brachial pressure index P 15 mm Hg was associated with a significant Cox stratified adjusted hazard ratio for subsequent stroke (hazard ratio, 2.42; 95% confidence interval, 1.27–4.60; P
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- 2018
23. Correlation between the 24-h urinary angiotensinogen or aldosterone level and muscle mass: Japan shimanami health promoting program study
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Michiya Igase, Kana Tsukuda, Masaki Mogi, Masatsugu Horiuchi, Katsuhiko Kohara, and Yasuharu Tabara
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Male ,Sarcopenia ,medicine.medical_specialty ,Physiology ,Urinary system ,Angiotensinogen ,Health Promotion ,Urine ,030204 cardiovascular system & hematology ,Healthy Aging ,Renin-Angiotensin System ,Excretion ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Japan ,Risk Factors ,Internal medicine ,Hand strength ,Electric Impedance ,Internal Medicine ,medicine ,Humans ,Muscle, Skeletal ,Aldosterone ,Aged ,Aged, 80 and over ,Anatomy, Cross-Sectional ,Hand Strength ,business.industry ,Confounding ,Middle Aged ,medicine.disease ,Endocrinology ,chemistry ,Arterial stiffness ,Female ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Abstract
Our previous report indicated that sarcopenia is associated with arterial stiffness and cardiovascular death. The renin-angiotensin system (RAS) plays an important role in cardiovascular disease and its activation may be correlated with sarcopenia according to basic research. However, few clinical studies have assessed the correlation between skeletal muscle loss and RAS component concentrations in healthy subjects. The purpose of this study was to investigate the relationships between the excretion of angiotensinogen (AGT) and aldosterone (Ald) in 24-h urine samples and clinical and sarcopenic indices. A total of 344 people participated in a voluntary medical check-up program, "Anti-Aging Doc", and underwent measurement of their sarcopenia-related indices. Urine samples were collected for 24-h within 8 weeks after a medical check-up using a partition cup and a proportional sampling method. Urine AGT and Ald levels were evaluated by enzyme-linked immunosorbent assay (ELISA). After compensating for possible confounding parameters, including baPWV, the 24-h urinary excretion of AGT was independently and negatively associated with the thigh muscle cross-sectional area. On the other hand, urinary Ald excretion was not associated with sarcopenia-related indices after compensation, even though it showed a modest but significantly positive association with sarcopenic indices in single regression analysis. Urinary AGT was related to sarcopenic indices and may be involved in the pathogenesis of sarcopenia. On the other hand, urinary Ald was not related to sarcopenic indices when considering other risk factors.
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- 2018
24. Association Between Body Mass Index and Functional Dyspepsia in Young Japanese People.
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Yasunori Yamamoto, Shinya Furukawa, Junichi Watanabe, Aki Kato, Katsunori Kusumoto, Eiji Takeshita, Yoshio Ikeda, Naofumi Yamamoto, Katsuhiko Kohara, Yuka Saeki, and Yoichi Hiasa
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YOUNG adults ,JAPANESE people ,BODY mass index ,JAPANESE women ,JAPANESE students - Abstract
Background/Aims Evidence regarding the association between body mass index (BMI) and functional dyspepsia (FD) in the Asian population is limited. Further, no study has evaluated this issue in young people in Asian and Western populations. Thus, we aim to investigate this issue among young Japanese people. Methods The study subjects comprised of 8923 Japanese university students. BMI was divided into 4 categories (quartiles) on the basis of the study subjects' distribution (lowest, low, moderate, and high [reference]). The definition of lean, normal, overweight, and obese was BMI < 18.5 kg/m2, 18.5 = BMI < 25 kg/m2 (reference), 25 kg/m2 = BMI < 30 kg/m2, and 30 kg/m2 = BMI, respectively. The definition of FD was based on the Rome III criteria. Results The prevalence of FD was 1.9% in this cohort. The lowest BMI was independently associated with FD after adjustment (adjusted odds ratio [OR], 2.88; 95% confidence interval [CI], 1.46-3.67); P for trend = 0.001). The lowest BMI was independently associated with FD in women but not in men (OR, 2.94; 95% CI, 1.59-5.77; P for trend = 0.001). Leanness was independently associated with FD in total and in women but not in men (total: adjusted OR, 2.01; 95% CI, 1.40-2.86) and women (OR, 2.19; 95% CI, 1.35-3.45). However, interaction analysis showed no significant difference for sex. Conclusions Among young Japanese people, BMI may be independently inversely associated with FD. Leanness may be an independent associated factor for FD in the young Japanese women. [ABSTRACT FROM AUTHOR]
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- 2022
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25. Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease
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Toshiaki Ohkuma, Toshiharu Ninomiya, Hirofumi Tomiyama, Kazuomi Kario, Satoshi Hoshide, Yoshikuni Kita, Toyoshi Inoguchi, Yasutaka Maeda, Katsuhiko Kohara, Yasuharu Tabara, Motoyuki Nakamura, Takayoshi Ohkubo, Hirotaka Watada, Masanori Munakata, Mitsuru Ohishi, Norihisa Ito, Michinari Nakamura, Tetsuo Shoji, Charalambos Vlachopoulos, Akira Yamashina, Masahide Nagano, Ogata Yukiyo, Tomoyuki Kabutoya, Kei Asayama, Naoyuki Takashima, Tanvir Turin Chowdhury, Kayo Mitsuki-Shinohara, and Takeshi Yamashita
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Male ,medicine.medical_specialty ,Brachial Artery ,Pulse Wave Analysis ,Disease ,030204 cardiovascular system & hematology ,Risk Assessment ,Cohort Studies ,03 medical and health sciences ,Age Distribution ,Vascular Stiffness ,0302 clinical medicine ,Physical medicine and rehabilitation ,Internal Medicine ,medicine ,Humans ,Ankle Brachial Index ,Prospective Studies ,030212 general & internal medicine ,Sex Distribution ,Prospective cohort study ,Aged ,Proportional Hazards Models ,business.industry ,Proportional hazards model ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Cardiovascular Diseases ,Meta-analysis ,Arterial stiffness ,Female ,Risk assessment ,business ,Cohort study - Abstract
An individual participant data meta-analysis was conducted in the data of 14 673 Japanese participants without a history of cardiovascular disease (CVD) to examine the association of the brachial-ankle pulse wave velocity (baPWV) with the risk of development of CVD. During the average 6.4-year follow-up period, 687 participants died and 735 developed cardiovascular events. A higher baPWV was significantly associated with a higher risk of CVD, even after adjustments for conventional risk factors ( P for trend P P P P
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- 2017
26. Muscle mass decline, arterial stiffness, white matter hyperintensity, and cognitive impairment: Japan Shimanami Health Promoting Program study
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Tokihisa Nagai, Katsuhiko Kohara, Michiya Igase, Maya Ohara, Yasuharu Tabara, Yoko Okada, and Masayuki Ochi
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medicine.medical_specialty ,business.industry ,Cognition ,030204 cardiovascular system & hematology ,medicine.disease ,Muscle mass ,Hyperintensity ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Sarcopenia ,Internal medicine ,medicine ,Arterial stiffness ,Cardiology ,Physical therapy ,Dementia ,Orthopedics and Sports Medicine ,business ,Cognitive impairment ,Pulse wave velocity ,030217 neurology & neurosurgery - Abstract
Background There is a close association between frailty and cognitive impairment. However, the underlying contribution of sarcopenia to the development of cognitive impairment is unclear. We investigated the possible association between muscle mass decline and cognitive impairment in a cross-sectional study of 1518 subjects aged 55 years or above. We also evaluated arterial stiffness and white matter hyperintensities (WMHs) as possible underlying mechanisms for this association. Methods Two sarcopenic indices were measured: thigh muscle cross-sectional area (CSA; calculated by computed tomography) and skeletal muscle mass (bioelectric impedance). Muscle mass decline was defined as either the bottom 10% or 20% of participants for each sex. Cognitive function was assessed using the Touch Panel-type Dementia Assessment Scale, and brachial–ankle pulse wave velocity was measured as an index of arterial stiffness. Results Both sarcopenic indices were modestly but significantly associated with brachial–ankle pulse wave velocity in male and female subjects. The presence of WMHs was significantly associated with low thigh muscle CSA in men and with low skeletal muscle mass in women. The Touch Panel-type Dementia Assessment Scale score was modestly but significantly and positively associated with thigh muscle CSA in men and skeletal muscle mass in women. Muscle mass decline in the bottom 10% of participants on both sarcopenic indices was significantly and independently related to cognitive impairment in women. Conclusions Lower sarcopenic indices are significantly related to lower cognitive scores. Arterial stiffness and WMHs could account, at least in part, for this association.
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- 2017
27. Cross-sectional study of equol producer status and cognitive impairment in older adults
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Yasumasa Ohyagi, Yasuharu Tabara, Katsuhiko Kohara, Michiya Igase, and Keiji Igase
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Creatinine ,Univariate analysis ,business.industry ,Cross-sectional study ,food and beverages ,Physiology ,Renal function ,General Medicine ,Odds ratio ,Equol ,medicine.disease ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,chemistry ,Medicine ,Dementia ,030212 general & internal medicine ,Risk factor ,business ,030217 neurology & neurosurgery - Abstract
AIM It is well known that consumption of isoflavones reduces the risk of cardiovascular disease. However, the effectiveness of isoflavones in preventing dementia is controversial. A number of intervention studies have produced conflicting results. One possible reason is that the ability to produce equol, a metabolite of a soy isoflavone, differs greatly in individuals. In addition to existing data, we sought to confirm whether an apparent beneficial effect in cognitive function is observed after soy consumption in equol producers compared with non-producers. METHODS The present study was a cross-sectional, observational study of 152 (male/female = 61/91, mean age 69.2 ± 9.2 years) individuals. Participants were divided into two groups according to equol production status, which was determined using urine samples collected after a soy challenge test. Cognitive function was assessed using two computer-based questionnaires (touch panel-type dementia assessment scale [TDAS] and mild cognitive impairment [MCI] screen). RESULTS Overall, 60 (40%) of 152 participants were equol producers. Both TDAS and prevalence of MCI were significantly higher in the equol producer group than in the non-producer group. In univariate analyses, TDAS significantly correlated with age, serum creatinine, estimated glomerular filtration rate and low-density lipoprotein cholesterol. In multiple regression analysis using TDAS as a dependent variable, equol producer (β = 0.236, P = 0.005) was selected as an independent variable. In addition, multiple logistic regression analysis to assess the presence of MCI showed that being an equol producer was an independent risk factor for MCI (odds ratio 3.961). CONCLUSIONS Compared with equol non-producers, equol producers showed an apparent beneficial effect in cognitive function after soy intake. Geriatr Gerontol Int 2017; 17: 2103-2108.
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- 2017
28. Dual Effects of a RETN Single Nucleotide Polymorphism (SNP) at –420 on Plasma Resistin: Genotype and DNA Methylation
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Wataru Nishida, Masaaki Ochi, Haruhiko Osawa, Jun Ohashi, Ryoichi Kawamura, Hiroshi Onuma, Yasumasa Ohyagi, Tatsuya Nishimiya, Yasuharu Tabara, Tetsuro Miki, Katsuhiko Kohara, Yasunori Takata, and Ryuichi Kawamoto
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Genotype ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Bisulfite sequencing ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,Biochemistry ,Monocytes ,Body Mass Index ,Cell Line ,Epigenesis, Genetic ,03 medical and health sciences ,Endocrinology ,Asian People ,Japan ,Internal medicine ,medicine ,Humans ,Resistin ,RNA, Messenger ,Epigenetics ,Aged ,Biochemistry (medical) ,Methylation ,DNA Methylation ,Middle Aged ,Molecular biology ,C-Reactive Protein ,030104 developmental biology ,Diabetes Mellitus, Type 2 ,CpG site ,DNA methylation ,CpG Islands ,Female - Abstract
We previously reported that single nucleotide polymorphism (SNP)-420 CG (rs1862513) in the promoter region of RETN was associated with type 2 diabetes. Plasma resistin was tightly correlated with SNP-420 genotypes. SNP-420 is a CpG-SNP affecting the sequence of cytosine-phosphate-guanine dinucleotides.To examine whether methylation at SNP-420 affects plasma resistin, we analyzed plasma resistin and methylation at RETN SNP-420.Genomic DNA was extracted from peripheral white blood cells in 2078 Japanese subjects. Quantification of the methylation was performed by pyrosequencing after DNA bisulfite conversion.Methylation at SNP-420 was highest in the C/C genotype (36.9 ± 5.7%), followed by C/G (21.4 ± 3.5%) and G/G (2.9 ± 1.4%; P0.001). When assessed in each genotype, methylation at SNP-420 was inversely associated with plasma resistin in the C/C (β = -0.134, P0.001) or C/G (β = -0.227, P0.001) genotype. In THP-1 human monocytes intrinsically having the C/C genotype, a demethylating reagent, 5-aza-dC, decreased the methylation at SNP-420 and increased RETN messenger RNA. SNP+1263 (rs3745369), located in the 3' untranslated region of RETN, was also associated with methylation at SNP-420. In addition, highly sensitive C-reactive protein was inversely associated with methylation at SNP-420 in the C/C genotype, whereas body mass index was positively associated.Plasma resistin was inversely associated with the extent of methylation at SNP-420 mainly dependent on the SNP-420 genotype. The association can also be explained partially independent of SNP-420 genotypes. SNP-420 could have dual, genetic and epigenetic effects on plasma resistin.
- Published
- 2016
29. Mendelian randomization analysis in three Japanese populations supports a causal role of alcohol consumption in lowering low-density lipid cholesterol levels and particle numbers
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Masaki Sumi, Akira Fujiyoshi, Takashi Hisamatsu, Yasuharu Tabara, Katsuyuki Miura, Naoyuki Takashima, Maryam Zaid, Katsuhiko Kohara, Tetsuro Miki, and Hirotsugu Ueshima
- Subjects
Adult ,Male ,medicine.medical_specialty ,Alcohol Drinking ,Genotype ,Lipoproteins ,Alcohol ,030204 cardiovascular system & hematology ,Biology ,Lipoprotein particle ,Cohort Studies ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Asian People ,Japan ,Internal medicine ,Cholesterylester transfer protein ,medicine ,Humans ,030212 general & internal medicine ,Particle Size ,Ethanol metabolism ,Alleles ,Aged ,ALDH2 ,Genetics ,Cholesterol ,Aldehyde Dehydrogenase, Mitochondrial ,Homozygote ,Mendelian Randomization Analysis ,Cholesterol, LDL ,Middle Aged ,Atherosclerosis ,Cholesterol Ester Transfer Proteins ,Lipoproteins, LDL ,Endocrinology ,chemistry ,biology.protein ,Female ,lipids (amino acids, peptides, and proteins) ,Lipoproteins, HDL ,Cardiology and Cardiovascular Medicine ,Lipoprotein - Abstract
While alcohol consumption is known to increase plasma high-density lipoprotein (HDL) cholesterol levels, its relationship with low-density lipoprotein (LDL) cholesterol levels is unclear. Aldehyde dehydrogenase 2 (ALDH2) is a rate-controlling enzyme in alcohol metabolism, but a large number of Japanese people have the inactive allele. Here, we conducted a Mendelian randomization analysis using the ALDH2 genotype to clarify a causal role of alcohol on circulating cholesterol levels and lipoprotein particle numbers.This study was conducted in three independent general Japanese populations (men, n = 2289; women, n = 1940; mean age 63.3 ± 11.2 years). Alcohol consumption was assessed using a questionnaire. Lipoprotein particle numbers were determined by nuclear magnetic resonance spectroscopy.Alcohol consumption increased linearly in proportion to the number of subjects carrying the enzymatically active *1 allele in men (p 0.001). The *1 allele was also positively associated with HDL cholesterol level (adjusted mean ± standard error, *1*1: 60 ± 0.5, *1*2: 56 ± 0.6, *2*2: 55 ± 1.3 mg/dl, p 0.001) and inversely associated with LDL cholesterol level (116 ± 0.9, 124 ± 1.1, 130 ± 2.6 mg/dl, p 0.001). The *1 allele was also positively associated with HDL particle numbers (per-allele: 2.60 ± 0.32 μmol/l, p 0.001) and inversely associated with LDL particle numbers (-67.8 ± 19.6 nmol/l, p = 0.001). Additional Mendelian randomization analysis failed to clarify the involvement of cholesteryl ester transfer protein in alcohol-related changes in lipoprotein cholesterol levels. No significant association was observed in women, presumably due to their small amount of alcohol intake.Alcohol consumption has a causal role in not only increasing HDL cholesterol levels but also decreasing LDL cholesterol levels and particle numbers.
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- 2016
30. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
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Tatsuo Shimosawa, Katsuyuki Miura, Hisashi Kai, Shuji Arima, Shigeyuki Saitoh, Takafumi Okura, Takanari Kitazono, Satoshi Hoshide, Kiyoshi Matsumura, Kei Kamide, Hirotaka Shibata, Yoshinari Uehara, Yuhei Kawano, Takeshi Horio, Masashi Mukoyama, Yoshitaka Hirooka, Toru Kikuchi, Yoshihiko Kanno, Masataka Kudo, Sadayoshi Ito, Yasuaki Dohi, Hisatomi Arima, Shori Takahashi, Hiromi Rakugi, Toshihiko Ishimitsu, Hideo Matsuura, Yusuke Ohya, Kei Asayama, Shinichiro Ueda, Hiromichi Suzuki, Hirofumi Tomiyama, Katsuhiko Kohara, Satoshi Umemura, Nobuhito Hirawa, Kouichi Tamura, Takuya Tsuchihashi, Shunya Ikeda, Takayoshi Ohkubo, Masaaki Ito, Hidenori Urata, Hiroo Kumagai, Naoki Kashihara, Satoko Nakamura, Kazuo Kitamura, and Yoshio Iwashima
- Subjects
Physiology ,business.industry ,Disease Management ,Blood Pressure Determination ,Japan ,Hypertension ,Internal Medicine ,Public Health Practice ,Medicine ,Humans ,Cardiology and Cardiovascular Medicine ,business ,Life Style ,Antihypertensive Agents - Published
- 2019
31. Identification of type 2 diabetes loci in 433,540 East Asian individuals
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Chien-Hsiun Chen, Anna L. Gloyn, Atsushi Takahashi, Sohee Han, Ken Suzuki, Mark A Pereira, Shi Jinxiu, Fiona Bragg, Yii-Der Ida Chen, Robin G. Walters, Takashi Kadowaki, Charumathi Sabanayagam, Annie-Green Howard, Mark I. McCarthy, Zheng Bian, Zhengming Chen, E-Shyong Tai, Chii-Min Hwu, Cassandra N. Spracklen, Yuan-Tsong Chen, Linda S. Adair, Momoko Horikoshi, Guozhi Jiang, Ching-Yu Cheng, Mi Yeong Hwang, Andrew P. Morris, Karen L. Mohlke, John C. Chambers, Jian-Min Yuan, Woon-Puay Koh, Hyeok Sun Choi, Ju Young Lee, Bong-Jo Kim, Masato Akiyama, Sahoko Ichihara, Xueling Sim, Norihiro Kato, Kuang Lin, Jirong Long, Xiuqing Guo, Fumihiko Takeuchi, Penny Gordon-Larsen, Hannah J Perrin, Young Jin Kim, Lee-Ming Chuang, Weihua Zhang, Rob M. van Dam, Andrea O.Y. Luk, Masahiro Nakatochi, Yukinori Okada, Katsuhiko Kohara, Yoichiro Kamatani, Jerome I. Rotter, Iona Y Millwood, Jer-Yuarn Wu, Canqing Yu, Wayne Huey-Herng Sheu, Shiro Maeda, Jost B. Jonas, Yasuharu Tabara, Mitsuhiro Yokota, Li-Ching Chang, Toshimasa Yamauchi, Shufa Du, Yu Guo, Yoon Shin Cho, Yi-Jen Hung, Jie Yao, Soo Heon Kwak, Hye-Mi Jang, Maggie C.Y. Ng, Xiao-Ou Shu, Myung-Shik Lee, Kyungheon Yoon, Sarah M Brotman, Sanghoon Moon, Tien Yin Wong, Martijn van de Bunt, Michiya Igase, Claudia H. T. Tam, Fumihiko Matsuda, Wei Zheng, Liang Zhang, Yong-Bing Xiang, Victor Jun Yu Lim, Ronald Cw Ma, Liming Li, Tomohiro Katsuya, Jianjun Liu, Jun Lv, Jennifer E. Below, Anubha Mahajan, Kyong-Soo Park, Masato Isono, Wing-Yee So, Nanette R. Lee, Brian Tomlinson, Juliana C.N. Chan, Lauren E. Petty, Chiea Chuen Khor, Miao-Li Chee, Ken Yamamoto, Wei Huang, Michael Boehnke, Jin-Fang Chai, Donald W. Bowden, Apoorva K Iyengar, Dong Mun Shin, Myron D. Gross, Takahisa Kawaguchi, Ya Xing Wang, and Fuu Jen Tsai
- Subjects
Ankyrins ,Male ,0301 basic medicine ,Transcription, Genetic ,endocrine system diseases ,Nerve Tissue Proteins ,030209 endocrinology & metabolism ,Locus (genetics) ,Genome-wide association study ,Type 2 diabetes ,Biology ,Article ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,ANK1 ,medicine ,Humans ,Genetic Predisposition to Disease ,RNA, Messenger ,Allele ,Eye Proteins ,Gene ,Alleles ,030304 developmental biology ,ALDH2 ,Genetic association ,2. Zero hunger ,Homeodomain Proteins ,Genetics ,0303 health sciences ,Multidisciplinary ,Asia, Eastern ,Aldehyde Dehydrogenase, Mitochondrial ,Case-control study ,nutritional and metabolic diseases ,medicine.disease ,Europe ,030104 developmental biology ,Diabetes Mellitus, Type 2 ,Case-Control Studies ,Meta-analysis ,Expression quantitative trait loci ,Female ,Body mass index ,030217 neurology & neurosurgery ,Genome-Wide Association Study ,Transcription Factors - Abstract
SUMMARYMeta-analyses of genome-wide association studies (GWAS) have identified >240 loci associated with type 2 diabetes (T2D), however most loci have been identified in analyses of European-ancestry individuals. To examine T2D risk in East Asian individuals, we meta-analyzed GWAS data in 77,418 cases and 356,122 controls. In the main analysis, we identified 298 distinct association signals at 178 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 56 loci newly implicated in T2D predisposition. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. New associations include signals in/near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that affect muscle and adipose differentiation. At another locus, eQTLs at two overlapping T2D signals act through two genes, NKX6-3 and ANK1, in different tissues. Association studies in diverse populations identify additional loci and elucidate disease genes, biology, and pathways.Type 2 diabetes (T2D) is a common metabolic disease primarily caused by insufficient insulin production and/or secretion by the pancreatic β cells and insulin resistance in peripheral tissues1. Most genetic loci associated with T2D have been identified in populations of European (EUR) ancestry, including a recent meta-analysis of genome-wide association studies (GWAS) of nearly 900,000 individuals of European ancestry that identified >240 loci influencing the risk of T2D2. Differences in allele frequency between ancestries affect the power to detect associations within a population, particularly among variants rare or monomorphic in one population but more frequent in another3,4. Although smaller than studies in European populations, a recent T2D meta-analysis in almost 200,000 Japanese individuals identified 28 additional loci4. The relative contributions of different pathways to the pathophysiology of T2D may also differ between ancestry groups. For example, in East Asian (EAS) populations, T2D prevalence is greater than in European populations among people of similar body mass index (BMI) or waist circumference5. We performed the largest meta-analysis of East Asian individuals to identify new genetic associations and provide insight into T2D pathogenesis.
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- 2019
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32. Association of office-based frailty score with hypertensive end organ damage in the J-SHIPP cross-sectional study
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Yoko Okada, Michiya Igase, Maya Ohara, Tokihisa Nagai, Yasuharu Tabara, Masayuki Ochi, and Katsuhiko Kohara
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Male ,Sarcopenia ,medicine.medical_specialty ,End organ damage ,Cross-sectional study ,Frail Elderly ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Natriuretic Peptide, Brain ,Odds Ratio ,medicine ,Humans ,Ankle Brachial Index ,030212 general & internal medicine ,Risk factor ,Muscle, Skeletal ,Geriatric Assessment ,Aged ,Aged, 80 and over ,Office based ,Hand Strength ,business.industry ,Odds ratio ,Middle Aged ,medicine.disease ,White Matter ,Cross-Sectional Studies ,Hypertension ,Physical therapy ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Frailty, a geriatric syndrome reflecting a state of reduced physiological reserve and increased vulnerability, is an independent risk factor for cardiovascular morbidity and mortality. However, the relationship between frailty and hypertensive end-organ damage is not fully established.We performed a cross-sectional study to investigate the association between frailty and end-organ damage in 1125 apparently healthy middle-aged to elderly subjects. We performed a simple frailty (SF) score that was easily obtainable in the office, in combination with low hand grip power and short one-leg standing (OLS) time. The association between SF score and hypertensive end-organ damage and other frailty-related parameters was evaluated. Odds ratio of SF score 1 to score 0 for the presence of hypertension was 1.9 [1.4-2.5, p.0001] and that of SF score 2 was 3.3 [2.1-5.3, p.0001]. SF score was also significantly associated with brachial-ankle pulse wave velocity (baPWV) and central pulse pressure (PP2). SF score was significantly associated with higher frailty index calculated from 21 parameters, lower cognitive test score, % vital capacity, skeletal muscle mass, and thigh muscle cross-sectional area. SF score was positively associated with stage of brain white matter hyperintenisty, plasma levels of B-type natriuretic peptide, and urinary protein excretion, even after correction for confounding parameters including baPWV and PP2.These findings indicate that frailty is significantly associated with end-organ damage in elderly subjects. SF score may be a useful clinical tool to identify frail subjects and advanced end-organ damage in elderly subjects.
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- 2016
33. Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women
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Takeaki Katoh, Ryuichi Kawamoto, Katsuhiko Kohara, Daisuke Ninomiya, Teru Kumagi, and Masanori Abe
- Subjects
Rural Population ,Aging ,medicine.medical_specialty ,030209 endocrinology & metabolism ,Walking ,030204 cardiovascular system & hematology ,Bioinformatics ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,Insulin resistance ,Exercise program ,Japan ,Internal medicine ,Bayesian multivariate linear regression ,medicine ,Humans ,Triglycerides ,Aged ,Postmenopausal women ,Triglyceride ,business.industry ,Serum uric acid ,General Medicine ,Middle Aged ,medicine.disease ,Exercise Therapy ,Uric Acid ,Rural village ,chemistry ,Female ,Independent Living ,Insulin Resistance ,business ,Training program - Abstract
Serum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated.The present study included 100 postmenopausal women (mean ± standard deviation, 68 ± 7 years) from a rural village in Japan. The Nordic walking program of 120 min per week was performed for 12 weeks. Before and after the intervention, SUA, TG, various relevant factors and homeostasis model assessment of insulin resistance (HOMA-IR) were measured.Multivariate linear regression analysis showed that baseline TG and γ-glutamyltransferase (GGT) were significantly associated with baseline HOMA-IR. After the 12-week training program, changes in TG, SUA and GGT were significantly associated with changes in HOMA-IR. In addition to their direct associations, we observed a synergistic association between changes in TG and SUA and changes in HOMA-IR. Participants were divided into three groups (tertiles) according to changes in TG and SUA. The tertiles of changes in SUA correlated significantly with changes in HOMA-IR in participants in the tertile with the greatest decrease in TG (r = 0.525, p = 0.001), but not in the other two tertiles of change in TG (r = 0.049, p = 0.699). There was a significant interaction between SUA and TG for changes in HOMA-IR (β = 0.281, p = 0.005). These results suggest that changes in TG and SUA are synergistic factors associated with changes in insulin resistance after a 12-week walking exercise program in community-dwelling older women.
- Published
- 2016
34. Relationship between sleep-disordered breathing and central systolic blood pressure in a community-based population: the Toon Health Study
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Kiyohide Tomooka, Katsuhiko Kohara, Koutatsu Maruyama, Ai Ikeda, Kenta Igami, Yasuharu Tabara, Isao Saito, and Takeshi Tanigawa
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Adult ,Male ,medicine.medical_specialty ,Physiology ,Polysomnography ,Population ,Blood Pressure ,030204 cardiovascular system & hematology ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Sleep Apnea Syndromes ,Japan ,Internal medicine ,Ideal weight ,Respiratory disturbance index ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,education ,Aged ,Community based ,education.field_of_study ,business.industry ,Confounding ,Blood Pressure Determination ,Middle Aged ,Health Surveys ,Blood pressure ,Cross-Sectional Studies ,Cardiology ,Breathing ,Sleep disordered breathing ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Sleep-disordered breathing (SDB) is linked with brachial blood pressure. Although central systolic blood pressure (cSBP) is a better predictor of cardiovascular diseases than is brachial blood pressure, the association between SDB and cSBP is not fully understood. This cross-sectional study included 1484 participants without cardiovascular diseases who were enrolled in the Toon Health Study between 2009 and 2012. The respiratory disturbance index (RDI) was estimated with a one-night sleep test using an airflow monitor. Participants were grouped into three categories according to RDI level: mild (
- Published
- 2018
35. Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis
- Author
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Yasutaka Maeda, Toshiharu Ninomiya, Mitsuru Ohishi, Motoyuki Nakamura, Toshiaki Ohkuma, Tetsuo Shoji, Toyoshi Inoguchi, Norihisa Ito, Yoshikuni Kita, Masanori Munakata, Akira Yamashina, Victor Aboyans, Kazuomi Kario, Takayoshi Ohkubo, Michinari Nakamura, Hirotaka Watada, Charalambos Vlachopoulos, Hirofumi Tomiyama, Katsuhiko Kohara, Satoshi Hoshide, Yasuharu Tabara, Tohoku University [Sendai], Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), and Grelier, Elisabeth
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Disease ,030204 cardiovascular system & hematology ,Risk Assessment ,Ankle–brachial index ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Predictive Value of Tests ,Internal medicine ,Cause of Death ,Oscillometry ,Individual participant data meta-analysis ,medicine ,Humans ,Ankle Brachial Index ,030212 general & internal medicine ,cardiovascular diseases ,Aged ,Framingham Risk Score ,business.industry ,Mortality, Premature ,Individual participant data ,Hazard ratio ,Middle Aged ,Prognosis ,Confidence interval ,3. Good health ,Plethysmography ,body regions ,medicine.anatomical_structure ,Risk factors ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Cardiovascular Diseases ,Meta-analysis ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Ankle ,Cardiology and Cardiovascular Medicine ,business ,human activities - Abstract
International audience; BACKGROUND AND AIMS:The ankle-brachial index (ABI) is a predictor of cardiovascular disease (CVD) and premature death. However, few studies on this marker are available in the general Asian populations. This study aimed to investigate the association between ABI measured with oscillometry and the risk of these outcomes.METHODS:We conducted an individual participant data meta-analysis in 10,679 community-dwelling Japanese individuals without a history of CVD. The primary outcome was a composite of CVD events and all-cause mortality.RESULTS:During an average of 7.8 years of follow-up, 720 participants experienced the primary outcome. The multivariable-adjusted hazard ratios (HRs) of the primary outcome significantly increased with a lower ABI. The HRs were 1.07 (95% confidence interval [CI] 0.91-1.27) for ABI of 1.00-1.09, HR 1.37 (95% CI 1.04-1.81) for ABI of 0.91-0.99, and HR 1.60 (95% CI 1.06-2.41) for ABI of ≤0.90, compared with ABI of 1.10-1.19. Furthermore, a high ABI (≥1.30) was associated with a greater risk of outcome (HR 2.42 [95% CI 1.14-5.13]). Similar tendencies were observed for CVD events alone and all-cause mortality alone. Addition of ABI to a model with the Framingham risk score marginally improved the c-statistics (p = 0.08) and integrated discrimination improvement (p < 0.05) for the primary outcome.CONCLUSIONS:The present study suggests that lower and higher ABI are significantly associated with an increased risk of CVD and all-cause mortality in the Japanese population. The ABI, which is easily measured by oscillometry, may be incorporated into daily clinical practice to identify high-risk populations.
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- 2018
36. Habitual hot water bathing protects cardiovascular function in middle-aged to elderly Japanese subjects
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Yasumasa Ohyagi, Masayuki Ochi, Tokihisa Nagai, Maya Ohara, Katsuhiko Kohara, Michiya Igase, Yasuharu Tabara, and Yoko Okada
- Subjects
Male ,medicine.medical_specialty ,Hot Temperature ,Time Factors ,Bathing ,medicine.drug_class ,lcsh:Medicine ,Hemodynamics ,Pulse Wave Analysis ,030204 cardiovascular system & hematology ,Carotid Intima-Media Thickness ,Article ,Habits ,03 medical and health sciences ,Sauna bathing ,0302 clinical medicine ,Japan ,Internal medicine ,Natriuretic peptide ,medicine ,Humans ,Longitudinal Studies ,cardiovascular diseases ,lcsh:Science ,Pulse wave velocity ,Aged ,Multidisciplinary ,business.industry ,lcsh:R ,Baths ,Middle Aged ,Stepwise regression ,Atherosclerosis ,Pulse pressure ,cardiovascular system ,Cardiology ,Female ,lcsh:Q ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Favorable effects of sauna bathing on cardiovascular disease have been demonstrated. Hot water bathing is an alternative, and could also have similar effects. Information pertaining to hot water bathing frequency and water temperature was obtained from 873 subjects. Carotid mean and max intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) were measured as indices of atherosclerosis. Central haemodynamics were evaluated using radial pulse waveform analyses. Plasma levels of B-type natriuretic peptide (BNP) were measured as an index for cardiac loading. The mean duration of a single hot bath was 12.4 ± 9.9 min. Subject bathing in hot water ≥5 times per week had significantly lower baPWV, central pulse pressure (PP), and BNP after correcting for possible confounding parameters. Stepwise regression analyses revealed that hot water temperature was negatively associated with baPWV, while bathing frequency was negatively related to central PP and BNP. A longitudinal follow-up in 164 subjects showed that hot water bathing ≥5 times per week was associated with significantly lower increase in BNP over time, while the temperature of the water tended to be related to lower increases in carotid max IMT and baPWV. Hot water bathing showed a favorable effect on atherosclerotic and central haemodynamic parameters.
- Published
- 2018
37. A double-blind, placebo-controlled, randomised clinical study of the effect of pork collagen peptide supplementation on atherosclerosis in healthy older individuals
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Naoki Inoue, Michiya Igase, Yoko Okada, Yasumasa Ohyagi, Keiji Igase, Masayuki Ochi, Hiromasa Miura, Katsuhiko Kohara, and Tatsuhiko Kutsuna
- Subjects
medicine.medical_specialty ,Pork Collagen ,Peptide ,030204 cardiovascular system & hematology ,Placebo ,Applied Microbiology and Biotechnology ,Biochemistry ,Placebo group ,Gastroenterology ,Analytical Chemistry ,Double blind ,Clinical study ,03 medical and health sciences ,0404 agricultural biotechnology ,0302 clinical medicine ,Internal medicine ,medicine ,Ingestion ,Molecular Biology ,chemistry.chemical_classification ,business.industry ,Organic Chemistry ,04 agricultural and veterinary sciences ,General Medicine ,040401 food science ,chemistry ,business ,Biotechnology - Abstract
We examined whether baPWV could be affected by pork collagen peptide (CP) ingestion. Seventy subjects were randomized into two groups (2.5 g/day CP and 2.5 g/day placebo). A significant reduction in baPWV was observed in the CP group compared to the placebo group. This study demonstrated that pork CP may contribute to the prevention of atherosclerosis in elderly.
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- 2018
38. Interethnic analyses of blood pressure loci in populations of East Asian and European descent
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Xiang Y-B., Charumathi Sabanayagam, Sohee Han, Jirong Long, Dermot F. Reilly, Jiang He, Iona Y Millwood, Masayuki Yamamoto, Zhengming Chen, Yaning Wang, Shu X-O., Derrick A Bennett, Huaixing Li, Karen L. Mohlke, Hiromi Rakugi, Jb Jonas, Sanghoon Moon, Nana Matoba, Xueling Sim, Jovia L. Nierenberg, Norihiro Kato, Juyoung Lee, Eitaro Nakashima, Makoto Hirata, Tatsuaki Matsubara, Kuang Lin, Nanette R. Lee, Liang Zhang, Xiaozhen Lin, Lei Xu, Wei Huang, Koichi Matsuda, Saw W-Y., Michiaki Kubo, Wei Zheng, Katsuhiko Kohara, Atsushi Takahashi, Rajkumar Dorajoo, Lanlan Li, Motohide Isono, Le Sun, Cassandra N. Spracklen, Toru Nabika, W Bin Wei, Chen C-H., Atsushi Hozawa, Masahiro Nakatochi, John C. Chambers, Chaolong Wang, Heng C-K., Jianjun Liu, Wu J-Y., Cheng C-Y., Jaspal S. Kooner, Chen Y-T., Tien Yin Wong, Chai J-F., Koh W-P., Tetsuro Miki, S Huo, Chang L-C., Kim Y-J., Michiya Igase, Linda S. Adair, Yuan J-M., Yasuharu Tabara, Penny Gordon-Larsen, Yechiel Friedlander, Masato Akiyama, Sahoko Ichihara, Robert Clarke, Tai E-S., Todd L. Edwards, Tanika N. Kelly, Teo Y-Y., Miao-Li Chee, Paul Elliott, Ken Yamamoto, Yukihide Momozawa, Weijie Zhao, Yoichiro Kamatani, Matsuyuki Shirota, Kim B-J., Tomohiro Katsuya, Akira Narita, Mi Yeong Hwang, Hui Cai, Mitsuhiro Yokota, Fumihiko Takeuchi, P. van der Harst, Robin G. Walters, Makoto Sasaki, Graduate School, Center of Experimental and Molecular Medicine, CCA - Imaging and biomarkers, CCA - Cancer biology and immunology, AII - Cancer immunology, AGEM - Re-generation and cancer of the digestive system, Epidemiology and Data Science, AGEM - Endocrinology, metabolism and nutrition, AGEM - Inborn errors of metabolism, Laboratory for Experimental Clinical Chemistry, APH - Personalized Medicine, APH - Methodology, Medical Research Council (MRC), National Institute for Health Research, Imperial College Healthcare NHS Trust- BRC Funding, UK DRI Ltd, RS: GROW - R1 - Prevention, Toxicogenomics, and Cardiovascular Centre (CVC)
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Male ,0301 basic medicine ,Linkage disequilibrium ,LINKAGE DISEQUILIBRIUM ,General Physics and Astronomy ,Blood Pressure ,Genome-wide association study ,Disease ,lcsh:Science ,Genetics ,International Genomics of Blood Pressure (iGEN-BP) Consortium ,ARCHITECTURE ,Multidisciplinary ,Natural selection ,Continental Population Groups ,HERITABILITY ,3. Good health ,Multidisciplinary Sciences ,Europe ,CARDIOVASCULAR-DISEASE ,RARE VARIANTS ,Science & Technology - Other Topics ,Female ,Medical Genetics ,FUNCTIONAL ANNOTATION ,Asian Continental Ancestry Group ,Science ,European Continental Ancestry Group ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,Article ,White People ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Asian People ,MD Multidisciplinary ,Humans ,GENOME-WIDE ASSOCIATION ,COMMON ,METAANALYSIS ,Medicinsk genetik ,Science & Technology ,Racial Groups ,General Chemistry ,Heritability ,BODY-MASS INDEX ,030104 developmental biology ,Blood pressure ,Genetic Loci ,lcsh:Q ,Selective sweep ,Genome-Wide Association Study - Abstract
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP., Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and report ancestry-specific BP SNPs and selection signals.
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- 2018
39. Determinants of change in insulin resistance response to Nordic walking in community-dwelling elderly women
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Tetsuro Miki, Katsuhiko Kohara, Ryuichi Kawamoto, and Takeaki Katoh
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medicine.medical_specialty ,business.industry ,Walk distance ,Elevated ggt ,medicine.disease ,Walking distance ,Insulin resistance ,Elderly persons ,elderly persons ,Functional abilities ,insulin resistance ,Physical therapy ,Medicine ,6-minute walking distance ,Geriatrics and Gerontology ,Training program ,business ,Nordic walking - Abstract
IntroductionNordic walking, characterized by the use of two walking poles, is becoming increasingly popular. The aim of this study was to analyze the effects produced by a 12-week Nordic walking training program on functional abilities and metabolic profiles, specifically walk distance and insulin resistance, among elderly women.MethodsThe present study included 74 women (68 ± 7 years). The Nordic walking training program of 120 minutes per week was performed for 12 weeks. Before and at the end of the 12-week intervention, 6-minute walking distance (6MWD) and the homeostasis of the model assessment of insulin resistance (HOMA-IR) were measured.Results and conclusionsAfter the 12-week Nordic walking training program, 6MWD increased significantly (p
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- 2015
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40. Diabetic mice exhibited a peculiar alteration in body composition with exaggerated ectopic fat deposition after muscle injury due to anomalous cell differentiation
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Hui-Yu Bai, Xiao-Li Wang, Harumi Kan-no, Bao-Shuai Shan, Hirotomo Nakaoka, Toshiyuki Chisaka, Kana Tsukuda, Katsuhiko Kohara, Tetsuro Miki, Masatsugu Horiuchi, Masaki Mogi, Jun Iwanami, and Masayoshi Kukida
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0301 basic medicine ,medicine.medical_specialty ,business.industry ,medicine.disease ,MyoD ,03 medical and health sciences ,030104 developmental biology ,Endocrinology ,Cardiotoxin ,Physiology (medical) ,Internal medicine ,Diabetes mellitus ,Enhancer binding ,medicine ,Orthopedics and Sports Medicine ,Sarcopenic obesity ,Intramuscular fat ,Progenitor cell ,Receptor ,business - Abstract
Background Sarcopenic obesity, age-related muscle loss, which is compensated by an increase in fat mass, impairs quality of life in elderly people. Although the increase in intramuscular fat is associated with decreased insulin sensitivity and increased metabolic risk factors, the origin of diabetes-associated intramuscular fat has not been elucidated. Here, we investigated intramuscular fat deposition using a muscle injury model in type 2 diabetic mice. Methods Male 8-week-old C57BL/6 and 8-week-old and 26-week-old KKAy underwent intramuscular injection of cardiotoxin (Ctx) (100 μL/10 μM) into the tibialis anterior (TA) muscles. After 2 weeks, the muscles were removed and evaluated. Results KKAy exhibited impaired muscle regeneration and ectopic fat deposition. Such impairment was more marked in older KKAy. These changes were also observed in another diabetic mouse model, db/db and diet-induced obese mice but not in streptozocin-induced diabetic mice. Deposited fat was platelet-derived growth factor (PDGF) receptor alpha positive and its cytoskeleton was stained with Masson's trichrome, indicating it to be of fibro-adipocyte progenitor cell origin. Expression of a myogenic marker, myoD, was lower and that of PDGF receptor alpha and CCAAT/enhancer binding protein (CEBP) alpha was higher in Ctx-injured TA of KKAy compared with that of C57BL/6. Peroxisome proliferator-activated receptor γ (PPARγ) was highly expressed in fat-forming lesions in older KKAy. Treatment with all-trans retinoic acid prevented the formation of intramuscular fat; however, treatment with GW9662, a PPARγ antagonist, increased the fibrotic change in muscle. Conclusions Diabetic mice showed impaired muscle regeneration with fat deposition, suggesting that diabetes may enhance sarcopenic obesity through a mechanism involving anomalous fibro-adipocyte progenitor cell differentiation.
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- 2015
41. Facial pigmentation as a biomarker of carotid atherosclerosis in middle-aged to elderly healthy Japanese subjects
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K. Sayama, Tetsuro Miki, Katsuhiko Kohara, S. Miyawaki, Tomoko Kido, Michiya Igase, and Yasuharu Tabara
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Adult ,Carotid Artery Diseases ,0301 basic medicine ,Carotid atherosclerosis ,medicine.medical_specialty ,Pathology ,Skin Pigmentation ,Dermatology ,030204 cardiovascular system & hematology ,Carotid imt ,Sensitivity and Specificity ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Reference Values ,Internal medicine ,Image Interpretation, Computer-Assisted ,Computer software ,Photography ,Prevalence ,medicine ,Humans ,cardiovascular diseases ,Pulse wave velocity ,Aged ,Skin ,Aged, 80 and over ,business.industry ,Mortality rate ,Reproducibility of Results ,Chronological age ,Middle Aged ,030104 developmental biology ,Face ,Skin color ,cardiovascular system ,Cardiology ,Biomarker (medicine) ,Colorimetry ,Female ,business ,Biomarkers - Abstract
Background/purpose Perceived age may be a better predictor of mortality rate than chronological age. We have demonstrated that perceived age was a significant biomarker for carotid atherosclerosis in Japanese. However, it remains to be determined which skin parameter is associated with atherosclerosis. The purpose of this study is to analyze the relationship between 10 facial skin-aging parameters and atherosclerosis in 169 middle-aged to elderly Japanese women who participated. Methods Facial photographs were taken under a shadowless lamp from three directions using a high-resolution digital camera. The digital images of each subject were analyzed using computer software and various parameters of skin aging such as pigmentation, wrinkles, and skin color were quantified. Carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) were measured as indices for atherosclerosis. Results Facial pigmentation showed a significant correlation with carotid IMT, even after correction for age (r = 0.13, P = 0.03), and with visceral fat area. Stepwise regression analysis indicated that facial pigmentation was associated with carotid IMT via visceral fat area. Conclusion Facial pigmentation may be a useful biomarker for carotid atherosclerosis in Japanese women.
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- 2015
42. Portable indices for sarcopenia are associated with pressure wave reflection and central pulse pressure
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Katsuhiko Kohara, Tetsuro Miki, Yasuharu Tabara, Maya Ohara, and Michiya Igase
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Male ,Sarcopenia ,Pulse Wave Analysis ,Physiology ,Blood Pressure ,Intra-Abdominal Fat ,Grip strength ,Vascular Stiffness ,Hand strength ,Electric Impedance ,Internal Medicine ,Humans ,Medicine ,Ankle Brachial Index ,Muscle, Skeletal ,Aged ,Hand Strength ,business.industry ,Middle Aged ,musculoskeletal system ,medicine.disease ,Pulse pressure ,Radiography ,body regions ,Cross-Sectional Studies ,Blood pressure ,Thigh ,Obesity, Abdominal ,Arterial stiffness ,Reflection (physics) ,Female ,Cardiology and Cardiovascular Medicine ,business ,human activities ,Biomedical engineering - Abstract
We recently reported that thigh muscle sarcopenia measured by computed tomography is related to arterial stiffness, pressure wave reflection, and central pulse pressure (PP). However, it remains to be determined whether more straightforward and simple techniques such as hand grip strength and the bio-impedance method are also useful for the clinical evaluation of sarcopenia.A total of 1593 middle-aged to older patients participated in this cross-sectional study. Brachial-to-ankle pulse wave velocity (baPWV) was measured as an index of arterial stiffness. Second PP (PP2) at the second peak of radial SBP was used to estimate central PP. Radial augmentation index was calculated as PP2/PP. Thigh muscle cross-sectional area and abdominal visceral fat area were quantified by computed tomography. Patients were classified as sarcopenic if their hand grip strength or skeletal muscle mass (measured by bioelectrical impedance) was more than 1 SD lower than the mean of those in a reference group aged below 50 years, or in the lowest 20% of the studied population. Visceral obesity was defined as visceral fat area greater than 100 cm.Antidyslipidemia drug and antidiabetic drug were significantly associated with lower hand grip strength. Both sarcopenic indices were significantly and independently associated with baPWV, radial augmentation index, and PP2. Sarcopenia defined by either criterion was significantly associated with higher baPWV, radial augmentation index, and PP2. Visceral obesity was significantly associated only with baPWV.These findings indicate the clinical usefulness of noninvasive methods for assessment of sarcopenia, which is a risk factor for cardiovascular disease.
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- 2015
43. Association between Serum Bilirubin and Estimated Glomerular Filtration Rate among Diabetic Patients
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Ryuichi Kawamoto, Takeaki Katoh, Tetsuro Miki, and Katsuhiko Kohara
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medicine.medical_specialty ,Article Subject ,business.industry ,Increased serum bilirubin ,Renal function ,Odds ratio ,Gastroenterology ,Confidence interval ,Serum bilirubin ,Medical department ,Endocrinology ,Quartile ,Internal medicine ,medicine ,business ,Antidiabetic agents ,Research Article - Abstract
The subjects comprised 230 men aged 77 ± 10 (range: 50–100) years and 279 women aged 81 ± 10 (50–101) years that visited the medical department. We examined the relationship between increased serum bilirubin and renal function evaluated by estimated glomerular filtration rate (eGFR) using CKD-EPI equations modified by a Japanese coefficient. Compared with the fourth quartile in serum bilirubin (1.01–1.97 mg/dL), the nonadjusted, age and gender-adjusted, and multivariate-adjusted odds ratios{95% confidence interval (CI)}of eGFR 2for the first quartile in serum bilirubin (0.13–0.50 mg/dL) were 2.08 (1.25–3.44), 1.82 (1.07–3.09), and 1.53 (0.83–2.81), respectively. Moreover, compared with the fourth quartile, nonadjusted, age and gender-adjusted, and multivariate-adjusted odds ratios (95% CI) of eGFR 2for the first quartile were 3.50 (1.95–6.23), 3.12 (1.72–5.65), and 3.53 (1.71–7.26), respectively. The data were further stratified by gender, age, medication (antihypertensive, antidyslipidemic, and antidiabetic agents), and prevalence of cardiovascular disease (CVD). The standardized coefficients for eGFR were significant in all the subgroups other than the prevalence of CVD, and there were significant interactions between the two groups regarding CVD. Our data demonstrated an independent positive association between serum bilirubin and eGFR among diabetic patients.
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- 2015
44. A case of ischemic stroke after recurrent transient ischemic attacks due to essential thrombocythemia with JAK2 mutation
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Takeaki Kato, Takaaki Hato, Tokihisa Nagai, Hirofumi Ochi, Yoko Okada, Taiji Yamashita, Masayuki Ochi, Katsuhiko Kohara, and Michiya Igase
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medicine.medical_specialty ,Essential thrombocythemia ,medicine.drug_class ,business.industry ,Jak2 mutation ,Anticoagulant ,medicine.disease ,Thrombosis ,Internal medicine ,Ischemic stroke ,medicine ,Cardiology ,Transient (computer programming) ,business - Published
- 2015
45. Mechanical Stresses, Arterial Stiffness, and Brain Small Vessel Diseases
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Yoko Okada, Yasuharu Tabara, Tokihisa Nagai, Michiya Igase, Tetsuro Miki, Katsuhiko Kohara, and Masayuki Ochi
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Male ,medicine.medical_specialty ,Hemodynamics ,Health Promotion ,Pulse Wave Analysis ,Vascular Stiffness ,Japan ,Risk Factors ,medicine.artery ,Internal medicine ,medicine ,Shear stress ,Humans ,Prospective Studies ,Common carotid artery ,Systole ,Pulse wave velocity ,Aged ,Aged, 80 and over ,Advanced and Specialized Nursing ,business.industry ,Brain ,Stiffness ,Middle Aged ,medicine.disease ,Cerebrovascular Disorders ,Cross-Sectional Studies ,Blood pressure ,Cerebrovascular Circulation ,Arterial stiffness ,Cardiology ,Female ,Stress, Mechanical ,Neurology (clinical) ,Radiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background and Purpose— Arterial stiffness, a risk factor of brain small vessel diseases (SVD), causes hemodynamic changes. Mechanical stresses, circumferential wall tension (WT), and shear stress (SS) may change with arterial stiffness and be related to SVD. We investigated the associations between mechanical stresses and arterial stiffness and SVD. Methods— A total of 1296 subjects without apparent cardiovascular diseases were recruited. Brachial-to-ankle pulse wave velocity (baPWV) was measured as an arterial stiffness index. Silent lacunar infarction and deep subcortical white matter hyperintensity were evaluated as SVD indices. Circumferential WT and SS at peak systole and end diastole were measured at the common carotid artery. Second peak of systolic blood pressure was obtained from the radial waveform and used as a central systolic blood pressure substitute. Results— baPWV was associated positively with WT ( P P =0.0007) even after correction for confounding parameters including baPWV. SVD was associated with significantly higher WT ( P P P =0.0017) and end diastolic WT (odds ratio, 1.60; P =0.0038) were related to presence of silent lacunar infarction, whereas peak systolic (odds ratio, 0.95; P =0.014) and end diastolic SS (odds ratio, 0.94; P =0.014) were associated with presence of deep subcortical white matter hyperintensity grade >3. Regression lines between blood pressure and WT were significantly steeper in subjects with SVD than without SVD (β=0.02; P Conclusions— These findings indicate that SVD is phenotype-specifically associated with alterations in WT and SS independently of arterial stiffness.
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- 2014
46. Proposed Cutoff Value of Brachial-Ankle Pulse Wave Velocity for the Management of Hypertension
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Michinari Nakamura, Motoyuki Nakamura, Hirofumi Tomiyama, Katsuhiko Kohara, Hirotaka Watada, Yasutaka Maeda, Norihisa Ito, Toshiharu Ninomiya, Tetsuo Shoji, Yoshikuni Kita, Takayoshi Ohkubo, Mitsuru Ohishi, Toyoshi Inoguchi, Satoshi Hoshide, Yasuharu Tabara, Charalambos Vlachopoulos, Kazuomi Kario, Toshiaki Ohkuma, Masanori Munakata, and Akira Yamashina
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Male ,medicine.medical_specialty ,030204 cardiovascular system & hematology ,Pulse Wave Analysis ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,medicine ,Ankle pulse ,Cutoff ,Humans ,Ankle Brachial Index ,cardiovascular diseases ,030212 general & internal medicine ,Pulse wave velocity ,business.industry ,Hazard ratio ,Wave velocity ,Curve analysis ,Disease Management ,General Medicine ,Middle Aged ,medicine.disease ,ROC Curve ,Cardiovascular Diseases ,Predictive value of tests ,Hypertension ,Arterial stiffness ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background The optimal cutoff values of the brachial-ankle pulse wave velocity (baPWV) for predicting cardiovascular disease (CVD) were examined in patients with hypertension.Methods and Results:A total of 7,656 participants were followed prospectively. The hazard ratio for the development of CVD increased significantly as the baPWV increased, independent of conventional risk factors. The receiver-operating characteristic curve analysis showed that the optimal cutoff values for predicting CVD was 18.3 m/s. This cutoff value significantly predicted THE incidence of CVD. Conclusions The present analysis suggests that the optimal cutoff value for CVD in patients with hypertension is 18.3 m/s.
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- 2017
47. Office-based simple frailty score and central blood pressure predict mild cognitive impairment in an apparently healthy Japanese population: J-SHIPP study
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Tokihisa Nagai, Yasumasa Ohyagi, Yasuharu Tabara, Masayuki Ochi, Katsuhiko Kohara, Yoko Okada, Maya Ohara, and Michiya Igase
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Male ,medicine.medical_specialty ,Cross-sectional study ,Population ,Blood Pressure ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,Grip strength ,0302 clinical medicine ,Japan ,Internal medicine ,mental disorders ,Odds Ratio ,Humans ,Medicine ,Dementia ,Cognitive Dysfunction ,education ,Geriatric Assessment ,Aged ,Aged, 80 and over ,education.field_of_study ,Multidisciplinary ,Frailty ,business.industry ,Body Weight ,Brain ,Odds ratio ,Middle Aged ,Stepwise regression ,medicine.disease ,Magnetic Resonance Imaging ,Healthy Volunteers ,Confidence interval ,Cross-Sectional Studies ,Blood pressure ,Physical therapy ,Female ,business ,030217 neurology & neurosurgery - Abstract
Frailty is associated with cognitive impairment and can be used to identify people at high risk for dementia. We developed a simple frailty (SF) score using a combination of low hand grip strength (
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- 2017
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48. Change in arterial stiffness associated with monthly bisphosphonate treatment in women with postmenopausal osteoporosis
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Masayuki Ochi, Tetsuro Miki, Yasuharu Tabara, Rie Takita, Yoko Okada, Katsuhiko Kohara, Maya Ohara, and Michiya Igase
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medicine.medical_specialty ,Brachial Artery ,Osteoporosis ,Administration, Oral ,Drug Administration Schedule ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Humans ,Ankle Brachial Index ,Prospective Studies ,Prospective cohort study ,Pulse wave velocity ,Osteoporosis, Postmenopausal ,Aged ,Bone mineral ,Alendronate ,Bone Density Conservation Agents ,Diphosphonates ,business.industry ,Incidence (epidemiology) ,Imidazoles ,Obstetrics and Gynecology ,Bone fracture ,Atherosclerosis ,medicine.disease ,Treatment Outcome ,Pulsatile Flow ,Arterial stiffness ,Female ,business - Abstract
Objective Osteoporosis and atherosclerosis are the two most common diseases in postmenopausal women. In most cases, they are simultaneously present in the same individual and commonly lead to bone fracture or cardiovascular disease (CVD). Bisphosphonates (BPs) are frequently used in the treatment of osteoporosis and have the ability to increase lumbar spine bone mineral density (L-BMD). BPs may also protect against CVD. A single monthly 50-mg dose of minodronate (monthly minodronate) is now common practice and is highly anticipated to reduce the incidence of both bone fracture and CVD. A useful approach to independently predicting CVD is brachial-ankle pulse wave velocity (baPWV). Here, we directly compared the effects of monthly minodronate with those of a standard single weekly 35-mg dose of alendronate (weekly alendronate) on L-BMD and baPWV in postmenopausal women with osteoporosis across a 12-month period. Methods Thirty-eight postmenopausal women with osteoporosis were randomized into two treatment groups (group 1, weekly alendronate, n = 19; group 2, monthly minodronate, n = 19). L-BMD and baPWV were assessed at baseline and 12-month follow-up. Results At the end of the 12-month period, increases in L-BMD were similar between group 1 (7.6%) and group 2 (8.5%), but baPWV was significantly reduced in group 2 compared with group 1. The change in baPWV during the study period showed a significant negative correlation with the change in L-BMD. Conclusions Changes in L-BMD in the monthly minodronate and weekly alendronate groups are generally comparable. Good control of changes in L-BMD in the postmenopausal phase might be associated with regression of CVD. Monthly minodronate is a promising new BP and potential first-line drug for the treatment of osteoporosis in postmenopausal women.
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- 2014
49. Clinical characteristics of high plasma adiponectin and high plasma leptin as risk factors for arterial stiffness and related end-organ damage
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Taiji Yamashita, Michiya Igase, Yasuharu Tabara, Tetsuro Miki, Maya Ohara, Tokihisa Nagai, Katsuhiko Kohara, Masayuki Ochi, Takeaki Kato, and Yoko Okada
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Leptin ,Male ,Sarcopenia ,medicine.medical_specialty ,End organ damage ,Population ,Intra-Abdominal Fat ,Vascular Stiffness ,Risk Factors ,Internal medicine ,medicine ,Albuminuria ,Humans ,Ankle Brachial Index ,education ,Pulse wave velocity ,Aged ,education.field_of_study ,Adiponectin ,business.industry ,Middle Aged ,medicine.disease ,Obesity ,Endocrinology ,Body Composition ,Arterial stiffness ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Blood Flow Velocity ,hormones, hormone substitutes, and hormone antagonists - Abstract
Objective The relationship between plasma levels of adiponectin and cardiovascular events is inconclusive. We evaluated the clinical characteristics of people with high plasma adiponectin and high plasma leptin levels. Methods Thousand seven hundred participants recruited from visitors to the Anti-Aging Doc were divided into four groups by combining the bipartiles of plasma adiponectin and leptin levels in men and women separately: AL, high adiponectin and high leptin; Al, high adiponectin and low leptin; al, low adiponectin and low leptin; aL, low adiponectin and high leptin. Body composition, including visceral fat area and thigh muscle cross-sectional area (CSA), brachial-ankle pulse wave velocity (baPWV), periventricular hyperintensity, and urinary albumin excretion, were determined. Results Twenty percent of the studied population fell within the AL group. This group had a significantly higher visceral fat area than the Al group. Thigh muscle CSA was lowest in the AL group among groups. baPWV, brain white matter lesions, and albuminuria findings in the AL group were significantly higher than those of the Al group. Multiple and logistic regression analyses with confounding parameters further confirmed that plasma adiponectin was not an independent determinant for brain and renal small vessel-related disease. Conclusion These findings suggest that the plasma level of adiponectin alone is not enough for the risk stratification of cardiovascular disease. Leptin resistance associated with skeletal muscle loss in addition to obesity may need to be addressed to identify high risk people with high plasma adiponectin levels.
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- 2014
50. Effect of weight loss on central systolic blood pressure in elderly community-dwelling persons
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Tomo Kusunoki, Masanori Abe, Tateaki Katoh, Ryuichi Kawamoto, Katsuhiko Kohara, Teru Kumagi, Tetsuro Miki, and Nobuyuki Ohtsuka
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Male ,medicine.medical_specialty ,Mean arterial pressure ,Physiology ,Blood Pressure ,Pulse Wave Analysis ,Body size ,Vascular Stiffness ,Heart Rate ,Risk Factors ,Weight loss ,Internal medicine ,Weight Loss ,Heart rate ,Internal Medicine ,medicine ,Body Size ,Humans ,Arterial Pressure ,Exercise physiology ,Exercise ,Aged ,business.industry ,Confounding ,Hemodynamics ,Peripheral ,Blood pressure ,Cardiology ,Physical therapy ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Central blood pressure (BP) has been shown to strongly associate with cardiovascular disease and outcome. Recent studies have demonstrated a relationship between changes in body size by exercise training and peripheral BP; however, the effect on changes in central BP is unknown. The aim of this study was to assess whether changes in body size are independently related to changes in central BP in the elderly. The subjects were 11 men (mean age, 68±6 years) and 84 women (68±7 years) from a rural village. Before and at the end of the 12-week training program, metabolic variables, and first peak radial systolic BP (SBP1) and second peak radial SBP (SBP2) as estimates of central SBP, were obtained. Radial augmentation index (AI) was calculated as follows: ((SBP2-diastolic BP (DBP))/(SBP1-DBP)) × 100 (%) and we used AI corrected at heart rate 75 per min (AI@75). After the 12-week training program, weight loss correlated strongly with reduction in brachial mean arterial pressure (MAP), radial SBP1, SBP2 and AI@75. After adjusting for confounding factors, weight loss was significantly and independently associated with each reduction in brachial MAP (β=0.34, P=0.001), radial SBP1 (β=0.31, P=0.002), SBP2 (β=0.37, P
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- 2014
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