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7. General Lectures

Author

Yamaoka, Y., Nagai, T., Furuta, K., Inagawa, T., Sugiya, T., Kai, T., Amamoto, H., Okunara, T., Miyoshi, A., Araya, S., Sometani, T., Ogura, T., Yamato, T., Hirata, S., Hashimoto, T., Hamanaka, Y., Shakudo, Y., Ozaki, T., Noda, S., Kobayashi, K., Sasaki, K., Matsuura, R., Ueno, H., Ito, T., Umayahara, A., Koga, Y., Watanabe, K., Nabeya, K., Shimura, I., Ohyama, O., Komatsuzaki, T., Ogoshi, K., Hara, Y., Hiratsuka, H., Kubo, N., Masuda, H., Inoue, S., Arakawa, H., Koizumi, K., Mukozima, K., Inoue, Y., Hosaka, H., Kikuchi, N., Yoshida, H., Sakumoto, I., Inaba, M., Yokoi, Y., Abei, T., Iwama, S., Shirota, A., Miki, M., Ōkawa, K., Onda, M., Yoshioka, M., Shiba, T., Yamashita, K., Moriyama, Y., Adachi, K., Miyashita, M., Henmi, H., Egami, K., Toi, K., Fukiwake, T., Ito, H., Tamesue, N., Ohsato, K., Nagamitsu, S., Nishimura, M., Yamashita, Y., Yao, T., Mizuno, S., Tanabe, M., Yanase, M., Suzuki, K., Suzuki, K., Hayashi, K., Nishitani, T., Katake, K., Iwasa, N., Nishimura, S., Miyoshi, M., Fukumoto, K., Fujii, H., Inatomi, I., Nakajima, H., Hojo, Y., Tosaka, T., Kaneko, H., Yoshikawa, K., Mori, K., Uematsu, T., Takahashi, T., Morikawa, S., Hashi, M., Sakamoto, T., Kimura, A., Sasagawa, T., Maeda, Y., Matsukawa, M., Aizawa, T., Tabata, I., Munakata, A., Toda, S., Tajima, T., Matsunaga, F., Ogata, T., Nakayama, K., Nakayama, T., Minota, S., Otani, A., Takei, S., Tanaka, M., Miki, H., Hojo, K., Hirota, E., Sano, R., Murashima, Y., Okuuti, Y., Miwa, K., Suga, T., Yaosaka, T., Namiki, M., Kawauti, H., Nakagawa, K., Kasukawa, T., Kobayashi, S., Watanabe, H., Yamagata, S., Narasaka, T., Imai, H., Tsuneoka, T., Watanabe, H., Hoshi, K., Nishiyama, S., Hoshi, K., Fushimi, I., Hirai, T., Katsuda, M., Hirose, M., Yokomori, H., Matsumoto, T., Watanabe, N., Matsuura, K., Ishibashi, T., Nakata, S., Takei, C., Asano, H., Miyoshi, H., Hidaka, T., Dodo, H., Kitada, A., Nakamura, T., Sakata, S., Kitamura, S., Nakamua, T., Sakata, S., Kitamura, S., Agata, E., Aikawa, K., Oshima, A., Fujimoto, I., Kobayashi, T., Asakawa, Y., Kusakari, M., Abe, C., Tarumi, S., Yamashita, T., Takasu, S., Komase, Y., Hamada, H., Shoji, F., Saito, S., Takayama, T., Fujita, R., Kumura, F., Umeda, K., Okamoto, S., Nishio, H., Shintani, Y., Saitoh, K., Tatara, T., Iwamiya, K., Tamura, M., Tamura, K., Nakano, A., Tamura, U., Nakajima, T., Ichioka, G., Takeuchi, Y., Ayada, K., Torisu, R., Kamada, H., Matuoka, R., Turuoka, M., Sagara, Y., Nakamura, S., Sakasita, O., Mashimo, N., Sekiguchi, T., Kobayashi, S., Kishimoto, H., Takeuchi, T., Murakami, S., Koga, S., Ueno, M., Nishizawa, M., Nomoto, K., Kariya, A., Hayashi, M., Kobayashi, S., Mizuno, K., Mayama, S., Shinozuka, T., Maruyama, T., Ogiwara, T., Okui, K., Higurashi, K., Ito, T., Miyata, Y., Tamura, T., Ikeda, S., Nakata, J., Oshima, H., Mori, S., Otsuka, Y., Oki, I., Tasaka, S., Yamahatsu, J., Inaba, E., Sanada, K., Oura, T., Kinoshita, T., Akagi, M., Katsuhisa, F., Misumi, A., Urashima, K., Ninomiya, S., Hukami, M., Mori, T., Matsuo, Y., Seki, A., Kitamura, T., Mori, H., Yokota, R., Kawashima, S., Itoshima, T., Shimada, Y., Itoshima, T., Inoue, T., Fukuhara, J., Kubota, M., Ohta, W., Ohta, W., Kagaya, T., Abe, R., Kai, Y., Katono, S., Komatsu, K., Masuda, H., Inoue, S., Arakawa, H., Hamajima, T., Kitamura, T., Nakagawa, F., Tamura, H., Kiyonaga, G., Inui, H., Asai, H., Hayashi, N., Obata, H., Toki, F., Kakae, U., Yamauchi, D., Hisamitsu, T., Aziki, K., Tamiya, M., Watanabe, S., Kurokawa, K., Takemoto, T., Murakami, S., Kessoku, Y., Kuwana, H., Hino, K., Kato, A., Ito, A., Arakawa, Y., Ohono, Y., Hase, M., Ariga, K., Usui, R., Kutsukake, S., Nagamori, S., Nagano, H., Shimano, K., Ohya, T., Kikuchi, S., Ito, M., Hidano, S., Banno, H., Tomura, A., Kato, K., Koyama, T., Komatsu, T., Takei, T., Tomimura, K., Yamauchi, M., Sato, G., Sato, R., Haga, M., Toyokawa, S., Yamamoto, J., Ohtomi, S., Ishibashi, Y., Fukuda, M., Endo, R., Ueno, Y., Hisamitsu, T., Sasaki, T., Kobayashi, C., Kusakari, T., Yajima, T., Maeda, M., Kotoda, K., Okuda, K., Ariga, H., Takazawa, G., Nakamura, Y., Ohbayashi, A., Mitsui, H., Nakata, K., Suematsu, T., Kashiwagi, T., Hayashi, N., Baba, T., Tobimatsu, Y., Kamada, T., Abe, H., Matsuoka, K., Matsushima, S., Kamisaka, Y., Kitsuki, T., Ohnuki, H., Fujii, M., Inoue, R., Yamamoto, T., Wakisaka, G., Nakagawa, S., Nagata, K., Takebayashi, J., Nagashima, H., Tanaka, N., Kanai, K., Oda, T., Katayama, T., Furukawa, Y., Miyasaki, R., Noguchi, M., Hirose, K., Maezawa, H., Kano, H., Hirano, K., Ogino, M., Nishiwaki, K., Aoki, T., Morishita, T., Funatsu, K., Morita, A., Okazaki, I., Matsuzaki, S., Oda, M., Asakura, H., Kamegaya, K., Tsuchiya, M., Sambe, K., Kawakami, H., Kunimasa, T., Aimitsu, A., Yamashita, S., Miyoshi, A., Enzan, H., Ikehara, K., Shiozaki, Y., Sameshima, Y., Mizuno, T., Sasakawa, M., Nagi, S., Nagata, T., Fuwa, H., Tatsumi, K., Komatsu, K., Ozeki, T., Kaneda, M., Otsuki, M., Tadaki, H., Miura, K., Yamagata, S., Iwamura, K., Yamanaka, I., Sugimoto, E., Yamazaki, Y., Shiraishi, I., Yamanaka, T., Koike, H., Shimura, S., Hirayama, Y., Nishikawa, H., Kawamura, T., Kamiyama, Y., Takeda, H., Kamano, Y., Kitamura, O., Yamaoka, Y., Nanbu, H., Ozawa, K., Takasan, H., Honjo, I., Itakura, H., Akanuma, Y., Kagaya, T., Kaito, I., Sato, S., Sahara, H., Arisue, T., Kashimura, K., Motoyama, W., Hayashi, H., Okuyama, S., Ito, S., Inagaki, T., Kato, Y., Kakumu, S., Kurokawa, S., Yamawaki, T., Kusakabe, A., Hara, T., Funayama, A., Takahashi, T., Furuta, S., Omori, A., Hanaoka, S., Nagata, A., Tsukioka, J., Kiyosawa, K., Akahane, Y., Koike, Y., Oda, M., Tanaka, K., Kojima, M., Kawaguchi, Y., Kimura, A., Osamura, H., Kurihara, N., Okabe, K., Fujisawa, K., Takahashi, T., Kitami, N., Namihisa, T., Yamaguchi, K., Hisauchi, T., Nambu, M., Iijima, K., Rin, K., Kuroda, H., Kobayashi, N., Inami, Y., Shiga, K., Kon, T., Yamada, T., Yamada, T., Mizoguchi, Y., Enomoto, T., Monna, T., Yamamoto, S., Morisawa, S., Imoto, S., Uchita, K., Yamasawa, Y., Hiraide, S., Hikita, G., Takatsuki, K., Okimoto, Y., Nakagawa, J., Ito, K., Hirayama, C., Kawasaki, H., Irisa, T., Arimura, K., Amagase, H., Shibasaki, K., Tashiro, S., Ichida, F., Tozawa, T., Ishii, M., Inoue, E., Ikehara, H., Baba, S., Miyaji, Y., Nakajima, K., Shimizu, T., Shimizu, Y., Ohnishi, S., Sasaki, S., Kinami, Y., Mizukami, T., Nishida, Y., Nakagawa, T., Ojima, T., Takeshita, Y., Yamashita, T., Furuto, T., Ono, T., Yamaguchi, K., Mizuno, S., Tsumori, K., Miyagi, K., Suga, Y., Tatsumi, S., Kitano, A., Makiishi, H., Mitani, E., Mohri, S., Kamata, T., Kobayashi, K., Yamamoto, S., Yoshii, T., Takemoto, T., Suzuki, H., Hiratsuka, H., Takada, K., Maruyama, M., Takemoto, T., Suzuki, H., Katsu, K., Nomura, M., Kiyama, T., Hirabayashi, H., Yamashita, H., Masuyama, S., Takehara, Y., Sato, T., Abe, H., Sugiura, M., Shima, F., Ichihara, S., Yamasaki, Z., Fukuzawa, S., Horiguchi, Y., Takeda, T., Nakano, S., Kitamura, K., Miwa, M., Suzuke, T., Okada, K., Nakamura, T., Kikuchi, T., Mishima, K., Mandai, M., Kondo, H., Yamagata, Y., Uchida, Y., Harada, H., Nishizawa, M., Nomoto, K., Kariya, A., Ueno, M., Hayashi, M., Kobayashi, S., Mizuno, K., Shinozuka, T., Maruyama, T., Ogiwara, T., Okui, K., Miyake, N., Okada, M., Takahashi, K., Koizumi, H., Hayashi, T., Maeda, H., Abe, M., Takahashi, I., Matsumoto, M., Unoura, T., Iwasaki, A., Hattori, T., Tanaka, M., Hara, T., Sato, H., Hirashima, T., Shioda, A., Kawamura, I., Muto, M., Tsuchiya, R., Sato, Y., Ozawa, T., Hatano, T., Arae, H., Sekine, T., Tsukamoto, M., Shiratori, T., Asaki, S., Oba, E., Yamagata, H., Kobiyama, M., Hisamichi, S., Kitagawa, M., Kobayashi, N., Kurosawa, T., Tokimatsu, S., Kawasaki, S., Iwasa, A., Nagashima, K., Kodeki, K., Hoshizawa, T., Murakami, H., Yagi, T., Matsuda, T., Iwazaki, T., Suzuki, Y., Taketomi, H., Akaike, Y., Naramoto, J., Tsuru, T., Inoue, M., Nagase, T., Kato, K., and Kohyama, K.

Published
1973
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8. Gamma-aminobutyric acid GABA and cell proliferation, focus on cancer cells

Author

Watanabe, M., Maemura, K., Oki, K., Shiraishi, N., Shibayama, Y., and Katsu, K.

Subjects
6 - Ciencias aplicadas::61 - Medicina [CDU], nervous system, Proliferation, Cancer
Abstract

In addition to its role in the adult mammalian nervous system as an inhibitory neurotransmitter, g-aminobutyric acid (GABA) is involved in the proliferation, differentiation, and migration of several kinds of cells including cancer cells. GABA is synthesized predominantly from glutamate by glutamate decarboxylase and exerts its effects via ionotropic GABAA receptors and/or metabotropic GABAB receptors. In this review, the current state of knowledge regarding the role of the GABAergic system in peripheral nonneuronal cell proliferation is described, and recent advances in elucidation of the mechanisms leading to cell proliferation are discussed.

Published
2006

9. A secreted BMP antagonist, Cer1, fine tunes the spatial organization of the ureteric bud tree during mouse kidney development

Author

Chi, L. (Lijun), Saarela, U. (Ulla), Railo, A. (Antti), Prunskaite-Hyyryläinen, R. (Renata), Skovorodkin, I. (Ilya), Anthony, S. (Shelagh), Katsu, K. (Kenjiro), Liu, Y. (Yu), Shan, J. (Jingdong), Salgueiro, A. M. (Ana Marisa), Belo, J. A. (José António), Davies, J. (Jamie), Yokouchi, Y. (Yuji), Vainio, S. J. (Seppo J.), Chi, L. (Lijun), Saarela, U. (Ulla), Railo, A. (Antti), Prunskaite-Hyyryläinen, R. (Renata), Skovorodkin, I. (Ilya), Anthony, S. (Shelagh), Katsu, K. (Kenjiro), Liu, Y. (Yu), Shan, J. (Jingdong), Salgueiro, A. M. (Ana Marisa), Belo, J. A. (José António), Davies, J. (Jamie), Yokouchi, Y. (Yuji), and Vainio, S. J. (Seppo J.)

Abstract

The epithelial ureteric bud is critical for mammalian kidney development as it generates the ureter and the collecting duct system that induces nephrogenesis in dicrete locations in the kidney mesenchyme during its emergence. We show that a secreted Bmp antagonist Cerberus homologue (Cer1) fine tunes the organization of the ureteric tree during organogenesis in the mouse embryo. Both enhanced ureteric expression of Cer1 and Cer1 knock out enlarge kidney size, and these changes are associated with an altered three-dimensional structure of the ureteric tree as revealed by optical projection tomography. Enhanced Cer1 expression changes the ureteric bud branching programme so that more trifid and lateral branches rather than bifid ones develop, as seen in time-lapse organ culture. These changes may be the reasons for the modified spatial arrangement of the ureteric tree in the kidneys of Cer1+ embryos. Cer1 gain of function is associated with moderately elevated expression of Gdnf and Wnt11, which is also induced in the case of Cer1 deficiency, where Bmp4 expression is reduced, indicating the dependence of Bmp expression on Cer1. Cer1 binds at least Bmp2/4 and antagonizes Bmp signalling in cell culture. In line with this, supplementation of Bmp4 restored the ureteric bud tip number, which was reduced by Cer1+ to bring it closer to the normal, consistent with models suggesting that Bmp signalling inhibits ureteric bud development. Genetic reduction of Wnt11 inhibited the Cer1-stimulated kidney development, but Cer1 did not influence Wnt11 signalling in cell culture, although it did inhibit the Wnt3a-induced canonical Top Flash reporter to some extent. We conclude that Cer1 fine tunes the spatial organization of the ureteric tree by coordinating the activities of the growth-promoting ureteric bud signals Gndf and Wnt11 via Bmp-mediated antagonism and to some degree via the canonical Wnt signalling involved in branching.

Published
2011

10. ChemInform Abstract: Studies on Orally Active Cephalosporins. Part 2. Synthesis and Structure-Activity Relations of New ((E) or (Z) 3-Substituted Carbamoyloxy)-1-propenylcephalosporins.

Author

NEGI, S., primary, SASHO, M., additional, YAMANAKA, M., additional, SUGIYAMA, I., additional, KOMATSU, Y., additional, TSURUOKA, A., additional, KAMADA, A., additional, TSUKADA, I., additional, HIRUMA, R., additional, KATSU, K., additional, and MACHIDA, Y., additional

Published
2010
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15. Evaluation of bubble image by RFA tratment under ultrasonography for HCC and correlation with coagulation area

Author

Fujiwara, S, primary, Miyaji, K, additional, Hongou, Y, additional, Kojima, H, additional, Arisaka, Y, additional, Siozaki, M, additional, Ozawa, M, additional, Hashimoto, K, additional, Fukuda, A, additional, Teramura, K, additional, Yoshimoto, G, additional, Fukui, H, additional, Tanabe, T, additional, Kogita, S, additional, and Katsu, K, additional

Published
2005
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25. K-ras gene mutations and immunohistochemical analysis of P53 protein of depressed and flat elevated minute colonic neoplasms-comparison between pit patterns

Author

Morikawa, H., primary, Hirata, I., additional, Nishikawa, T., additional, Nakagawa, Y., additional, Hamamoto, N., additional, Murano, S., additional, Sasaki, S., additional, Tanaka, M., additional, Katake, Y., additional, Maemura, K., additional, Matsunoto, A., additional, Saito, O., additional, Shimamoto, C., additional, and Katsu, K., additional

Published
1998
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30. Immunohistochemical analysis of P53 protein, and RCK/P54 protein in colonic invasive cancers

Author

Nakagawa, Y., primary, Morikawa, H., additional, Hirata, I., additional, Nishikawa, T., additional, Hamamoto, N., additional, Murano, S., additional, Toshina, K., additional, Sasaki, S., additional, Tanaka, M., additional, Katake, Y., additional, Maemura, K., additional, Matsunoto, A., additional, Saito, O., additional, Shimamoto, C., additional, and Katsu, K., additional

Published
1998
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36. ChemInform Abstract: Studies on Orally Active Cephalosporins. Part 1. Synthesis and Structure‐Activity Relationships of New 3‐Substituted Carbamoyloxymethyl Cephalosporins.

Author

NEGI, S., primary, YAMANAKA, M., additional, SUGIYAMA, I., additional, KOMATSU, Y., additional, SASHO, M., additional, TSURUOKA, A., additional, KAMADA, A., additional, TSUKADA, I., additional, HIRUMA, R., additional, KATSU, K., additional, and MACHIDA, Y., additional

Published
1995
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47. Novel Rana keratin genes and their expression during larval to adult epidermal conversion in bullfrog tadpoles.

Author

Suzuki, K., Sato, K., Katsu, K., Hayashita, H., Bach Kristensen, D., and Yoshizato, K.

Subjects
TADPOLES, BULLFROG, KERATIN, METAMORPHOSIS, THYROID hormones, DEVELOPMENTAL biology, GENETICS
Abstract

Abstract The conversion of the larval to adult epidermis during metamorphosis of tadpoles of bullfrog, Rana catesbeiana, was investigated utilizing newly cloned Rana keratin cDNAs as probes. Rana larval keratin (RLK) cDNA (rlk) was cloned using highly specific antisera against Xenopus larval keratin (XLK). Tail skin proteins of bullfrog tadpoles were separated by 2-dimensional gel electrophoresis and subjected to Western blot analysis with anti-XLK antisera. The Rana antigen detected by this method was sequenced and identified as a type II keratin. We cloned rlk from tadpole skin by PCR utilizing primers designed from these peptide sequences of RLK. RLK predicted by nucleotide sequences of rlk was a 549 amino acid -long type II keratin. Subtractive cloning between the body and the tail skin of bullfrog tadpole yielded a cDNA (rak) of Rana adult keratin (RAK). RAK was a 433 amino acid-long type I keratin. We also cloned a Rana keratin 8 (RK8) cDNA (rk8) from bullfrog tadpole epidermis. RK8 was 502 amino acid-long and homologous to cytokeratin 8. Northern blot analyses and in situ hybridization experiments showed that rlk was actively expressed through prometamorphosis in larva-specific epidermal cells called skein cells and became completely inactive at the climax stage of metamorphosis and in the adult skin. RAK mRNA was expressed in basal cells of the tadpole epidermis and germinative cells in the adult epidermis. The expression of rlk and rak was down- and up-regulated by thyroid hormone (TH), respectively. In contrast, there was no change in the expression of RK8 during spontaneous and TH-induced metamorphosis. RK8 mRNA was exclusively expressed in apical cells of the larval epidermis. These patterns of keratin gene expression indicated that the expression of keratin genes is differently regulated by TH depending on the type of larval epidermal cells. The present study demonstrated the usefulness of these genes for the study of molecular mechanism of... [ABSTRACT FROM AUTHOR]

Published
2001
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48. Enprostil, a Prostaglandin-E2 Analogue, Inhibits Interleukin-8 Production of Human Colonic Epithelial Cell Lines.

Author

Toshina, K., Hirata, I., Maemura, K., Sasaki, S., Murano, M., Nitta, M., Yamauchi, H., Nishikawa, T., Hamamoto, N., and Katsu, K.

Subjects
COLITIS treatment, COLON cancer, CELL lines
Abstract

We previously reported that intracolonic administration of enprostil, a prostaglandin-E2 (PGE2) analogue, had therapeutic effects on acute colitis induced in rodents by dextran sulfate sodium (DSS). In addition, production of growth-regulated gene product/cytokine-induced neutrophil chemoattractant-1 [GRO/CINC-1; an interleukin(IL)-8 like cytokine] was suppressed in the inflamed tissues. In the present study we used a human colon cancer cell line (HT-29) to investigate enprostil effects on the IL-8 production of intestinal epithelial cells stimulated by various stimulants. In a MTT assay, concentrations of enprostil >10-5M had cytotoxitic effects on HT-29 cells. Furthermore, 10-6 M enprostil suppressed IL-8 production in HT-29 cells, SW620 and CaCo2 stimulated with interleukin-1β (IL-1β) or lipopolysaccharide (LPS), but did not suppress this response when cells were stimulated with tumour necrosis factor (TNF)-α. These results suggest that enprostil affects a point in the pathway between the IL-1 receptor or LPS receptor and nuclear factor-κB(NF-κB), without affecting the pathway between the TNF receptor and NF-κB, with the latter factor being required for the IL-8 gene transcription. The therapeutic effect of exogenous enprostil on DSS colitis may involve the inhibition of IL-8 production in colonic epithelial cells stimulated by IL-1β or LPS. [ABSTRACT FROM AUTHOR]

Published
2000
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49. Acquired ileal diverticulum: an unusual bleeding source.

Author

Matsumoto, Akio, Saitoh, Osamu, Matsumoto, Hisashi, Yamauchi, Hiroaki, Inoue, Toshihiro, Katoh, Hitoshi, Masumoto, Hirofumi, Morikawa, Hiroshi, Hirata, Ichiro, Katsu, Ken-ichi, Matsumoto, A, Saitoh, O, Matsumoto, H, Yamauchi, H, Inoue, T, Katoh, H, Masumoto, H, Morikawa, H, Hirata, I, and Katsu, K

Subjects
DIVERTICULITIS, GASTROINTESTINAL hemorrhage, ANGIOGRAPHY
Abstract

Acquired ileal diverticulum is an uncommon condition and diagnosis is often difficult when bleeding occurs from this source. Here we describe two cases of ileal diverticulum with massive bleeding. Both patients presented with anal bleeding, but upper and lower gastrointestinal endoscopy did not reveal the source. Selective visceral angiography finally detected bleeding lesions in the terminal ileum. Surgical resection was performed in both patients, confirming that the bleeding arose from diverticula less than 1 cm in size. In patients with obscure gastrointestinal bleeding, an ileal diverticulum should be considered, and selective visceral angiography should be performed for precise diagnosis. [ABSTRACT FROM AUTHOR]

Published
2000
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50. Effect of upper gastrointestinal endoscopy on circulation in the elderly.

Author

Shimamoto, Chikao, Hirata, Ichiro, Katsu, Ken-ichi, Shimamoto, C, Hirata, I, and Katsu, K

Subjects
GASTROINTESTINAL system, ENDOSCOPY, OLDER people, ATRIAL natriuretic peptides, CARDIAC arrest, CARDIAC arrest prevention, ADRENALINE, AGING, BLOOD pressure, CARDIOVASCULAR system physiology, HEART beat, HEMODYNAMICS, MYOSIN, NORADRENALINE, PARASYMPATHOMIMETIC agents, PEPTIDE hormones, SHOCK (Pathology), TROPONIN, ENDOSCOPIC gastrointestinal surgery, PREVENTION
Abstract

Background: Upper gastrointestinal endoscopy in the elderly is increasingly becoming more common, despite the possibility that a minimal load on the circulation can cause serious complications such as shock and cardiac arrest.Objective: The effects of endoscopy on the heart and the possibility of predicting circulatory accidents were studied using natriuretic peptide levels.Methods: The patients were randomly chosen according to their age and divided into an elderly group (over 60 years of age, 64 patients) and a young group (under 30 years of age, 20 patients). The patients in the elderly group were further subdivided into two groups based on the presence or absence of circulatory complications (46 patients with circulatory complications and 18 without complications). The load on the heart was evaluated by measuring human atrial natriuretic peptide (hANP) and human brain natriuretic peptide (hBNP) which are secreted by the myocardial cells in response to cardiac load. Specimens were obtained before and after endoscopy.Results: The hANP level was significantly higher after endoscopy in the elderly group, regardless of the presence or absence of circulatory complications. No significant difference was observed in the hBNP level. No significant increase in hANP or hBNP levels was observed after endoscopy in the young group.Conclusions: These observations suggest an increased atrial load during endoscopy in the elderly. The increase in pulse rate during endoscopy is one possible cause of atrial load. Therefore, the risk of circulatory system damage must be recognized when endoscopy is performed in the elderly. The measurement of plasma hANP and hBNP levels may provide effective indices for evaluating cardiac load during endoscopy. [ABSTRACT FROM AUTHOR]

Published
1999
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