Search

Your search keyword '"Katsaras, Dimitrios"' showing total 25 results
Start Over Author "Katsaras, Dimitrios"
25 results on '"Katsaras, Dimitrios"'

1. Prediction of mortality benefit based on periodic repolarisation dynamics in patients undergoing prophylactic implantation of a defibrillator: a prospective, controlled, multicentre cohort study

Author

Merkely, Béla, Perge, Peter, Sallo, Zoltan, Szeplaki, Gabor, Zabel, Markus, Lüthje, Lars, Schlögl, Simon, Haarmann, Helge, Bergau, Leonard, Seegers, Joachim, Hasenfuß, Gerd, Munoz-Exposito, Pascal, Tichelbäcker, Tobias, Kirova, Aleksandra, Friede, Tim, Harden, Markus, Malik, Marek, Hnatkova, Katerina, Vos, Marc, Willich, Stefan N., Reinhold, Thomas, Willems, Rik, Vandenberk, Bert, Klinika, Magdalena, Toplice, Krapinske, Flevari, Panayota, Katsimardos, Andreas, Katsaras, Dimitrios, Hatala, Robert, Svetlosak, Martin, Lubinski, Andrzej, Kuczejko, Tomasz, Hansen, Jim, Sticherling, Christian, Conen, David, Milosrdnice, Sestre, Pavlović, Nikola, Manola, Šime, Vinter, Ozren, Benko, Ivica, Tuinenburg, Anton, Bauer, Axel, Meyer-Zürn, Christine, Eick, Christian, Hastrup, Jesper, Brugada, Josep, Arbelo, Elena, Kaliska, Gabriela, Martinek, Jozef, Dommasch, Michael, Steger, Alexander, Kääb, Stefan, Sinner, Moritz F., Rizas, Konstantinos D., Hamm, Wolfgang, Vdovin, Nikolay, Klemm, Mathias, von Stülpnagel, Lukas, Cygankiewicz, Iwona, Ptaszynski, Pawel, Kaczmarek, Krzysztof, Poddebska, Izabela, Iovev, Svetoslav, Novotný, Tomáš, Kozak, Milan, Huikuri, Heikki, Kenttä, Tuomas, Pelli, Ari, Kasprzak, Jaroslaw D., Qavoq, Dariusz, Brusich, Sandro, Avdovic, Ervin, Klasan, Marina, Galuszka, Jan, Taborsky, Milos, Velchev, Vasil, Dissmann, Rüdiger, Guzik, Przemysław, Bimmel, Dieter, Lieberz, Christiane, Stefanow, Stefan, Rüb, Norman, Wolpert, Christian, Maier, Lars S., Behrens, Steffen, Jurisic, Zrinka, Braunschweig, Frieder, Blaschke, Florian, Pieske, Burkert, Bakotic, Zoran, Anic, Ante, Schwinger, Robert H.G., Platonov, Pyotr, Rizas, Konstantinos D, Lubinski, Andrezej, Flevari, Panagiota, Merkely, Bela, and Schmidt, Georg

Published
2019
Full Text
View/download PDF

2. Box Lesion Isolation of the Left Atrial Posterior Wall with Radiofrequency Ablation Restricted in Predetermined Lines for the Treatment of Persistent Atrial Fibrillation: The Prognostic Role of Acute Interventional Outcome and Trigger Identification

Author

IOANNIDIS, PANAGIOTIS, primary, KATSARAS, DIMITRIOS, additional, ZOGRAFOS, THEODOROS, additional, CHARALAMBOPOULOS, PANAGIOTIS, additional, KOUVELAS, KONSTANTINOS, additional, TSITSINAKIS, GEORGIOS, additional, RAITSOS-EXARCHOPOULOS, IOANNIS, additional, KAPPOU, THEODORA, additional, ZAGORAIOS, ANASTASIOS, additional, GANAS, PANAGIOTIS, additional, VASSILOPOULOS, ALEXANDROS, additional, XYLAKIS, EMMANOUIL, additional, and CHRISTOFORATOU, EVANGELIA, additional

Published
2023
Full Text
View/download PDF

4. Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy

Author

Bergau, Leonard, Willems, Rik, Sprenkeler, David J., Fischer, Thomas H., Flevari, Panayota, Hasenfuß, Gerd, Katsaras, Dimitrios, Kirova, Aleksandra, Lehnart, Stephan E., Lüthje, Lars, Röver, Christian, Seegers, Joachim, Sossalla, Samuel, Dunnink, Albert, Sritharan, Rajevaa, Tuinenburg, Anton E., Vandenberk, Bert, Vos, Marc A., Wijers, Sofieke C., Friede, Tim, and Zabel, Markus

Published
2018
Full Text
View/download PDF

8. Clinical effectiveness of primary prevention implantable cardioverter-defibrillators: results of the EU-CERT-ICD controlled multicentre cohort study

Author

Zabel, Markus, Willems, Rik, Lubinski, Andrzej, Bauer, Axel, Brugada, Josep, Conen, David, Flevari, Panagiota, Hasenfuß, Gerd, Svetlosak, Martin, Huikuri, Heikki V, Malik, Marek, Pavlović, Nikola, Schmidt, Georg, Sritharan, Rajevaa, Schlögl, Simon, Szavits-Nossan, Janko, Traykov, Vassil, Tuinenburg, Anton E, Willich, Stefan N, Harden, Markus, Friede, Tim, Svendsen, Jesper Hastrup, Sticherling, Christian, Merkely, Béla, Perge, Peter, Sallo, Zoltan, Szeplaki, Gabor, Szegedi, Nandor, Nagy, Klaudia Vivien, Lüthje, Lars, Sritharan, R, Haarmann, Helge, Bergau, Leonard, Seegers, Joachim, Munoz- Exposito, Pascal, Tichelbäcker, Tobias, Kirova, Aleksandra, Hnatkova, Katerina, Vos, Marc A, Reinhold, Thomas, Vandenberk, Bert, Klinika, Magdalena, Rotkvić, L, Flevari, Panayota, Katsimardos, Andreas, Katsaras, Dimitrios, Hatala, Robert, Kuczejko, Tomasz, Hansen, Jim, Manola, Šime, Vinter, Ozren, Benko, Ivica, Tuinenburg, Anton, Sprenkeler, David, Smoczynska, A, Vos, M A, Meyer-Zürn, Christine, Eick, Christian, Arbelo, Elena, Kaliska, Gabriela, Martinek, Jozef, Dommasch, Michael, Steger, Alexander, Kääb, Stefan, Sinner, Moritz F, Rizas, Konstantinos D, Hamm, Wolfgang, Traykov, V, Cygankiewicz, Iwona, Ptaszyński, Pawel, Kaczmarek, K, Poddebska, I, Iovev, Svetoslav, Novotný, Tomáš, Kozak, Milan, Huikuri, Heikki, Kenttä, Tuomas, Pelli, Ari, Kasprzak, Jaroslaw D, Qavoq, Dariusz, Brusich, Sandro, Avdovic, Ervin, Klasan, Marina, Galuszka, Jan, Taborsky, Milos, Velchev, Vasil, Dissmann, Rüdiger, Shalganov, T, Guzik, P, Krauze, T, Bimmel, Dieter, Lieberz, Christiane, Ludwigsburg, Klinikum, Stefanow, Stefan, Rüb, Norman, Wolpert, Christian, Meier, Lars S, Behrens, Steffen, Jurisic, Zrinka, Braunschweig, Frieder, Blaschke, Florian, Pieske, Burkert, Bakotic, Zoran, Anic, Ante, Weiden, Klinikum, Schwinger, Robert H G, Platonov, Pyotr, Grönefeld, Gerian, Klingenheben, Thomas, and EU-CERT-ICD Study Investigators

Subjects
medicine.medical_specialty, medicine.medical_treatment, Implantable cardioverter-defibrillator, Risk factors, Mortality, Sudden cardiac death, 030204 cardiovascular system & hematology, Ventricular Function, Left, Cohort Studies, EU-CERT-ICD Study Investigators, 03 medical and health sciences, 0302 clinical medicine, Clinical Research, Internal medicine, medicine, Clinical endpoint, Humans, AcademicSubjects/MED00200, Prospective Studies, 030212 general & internal medicine, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine, 1102 Cardiorespiratory Medicine and Haematology, Aged, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, Heart Failure, Ejection fraction, Ischemic cardiomyopathy, business.industry, Hazard ratio, Stroke Volume, 1103 Clinical Sciences, Dilated cardiomyopathy, medicine.disease, Confidence interval, Defibrillators, Implantable, 3. Good health, Europe, Primary Prevention, Death, Sudden, Cardiac, Treatment Outcome, Cardiovascular System & Hematology, Implantable cardioverter-defibrillator, Risk factors, Mortality, Sudden cardiac death, Cardiology and Cardiovascular Medicine, business, Cohort study
Abstract

Aims The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter-Defibrillators (EU-CERT-ICD), a prospective investigator-initiated, controlled cohort study, was conducted in 44 centres and 15 European countries. It aimed to assess current clinical effectiveness of primary prevention ICD therapy. Methods and results We recruited 2327 patients with ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and guideline indications for prophylactic ICD implantation. Primary endpoint was all-cause mortality. Clinical characteristics, medications, resting, and 12-lead Holter electrocardiograms (ECGs) were documented at enrolment baseline. Baseline and follow-up (FU) data from 2247 patients were analysable, 1516 patients before first ICD implantation (ICD group) and 731 patients without ICD serving as controls. Multivariable models and propensity scoring for adjustment were used to compare the two groups for mortality. During mean FU of 2.4 ± 1.1 years, 342 deaths occurred (6.3%/years annualized mortality, 5.6%/years in the ICD group vs. 9.2%/years in controls), favouring ICD treatment [unadjusted hazard ratio (HR) 0.682, 95% confidence interval (CI) 0.537–0.865, P = 0.0016]. Multivariable mortality predictors included age, left ventricular ejection fraction (LVEF), New York Heart Association class Conclusion In contemporary ICM/DCM patients (LVEF ≤35%, narrow QRS), primary prophylactic ICD treatment was associated with a 27% lower mortality after adjustment. There appear to be patients with less survival advantage, such as older patients or diabetics.

Published
2020
Full Text
View/download PDF

9. Comparative safety and efficacy of paracetamol versus non‐steroidal anti‐inflammatory agents in neonates with patent ductus arteriosus: A systematic review and meta‐analysis of randomized controlled trials

Author

Katsaras, Dimitrios N., primary, Katsaras, Georgios N., additional, Chatziravdeli, Vasiliki I., additional, Papavasileiou, Garyfalia N., additional, Touloupaki, Maria, additional, Mitsiakos, Georgios, additional, Doxani, Chrysoula, additional, Stefanidis, Ioannis, additional, and Dardiotis, Efthimios, additional

Published
2022
Full Text
View/download PDF

12. Intermittent Loss of Telemetry Data

Author

Katsaras, Dimitrios, primary, Cassidy, Christopher, additional, Lakha, Mohammed, additional, Gordon, Dawn, additional, Goode, Grahame, additional, and Abozguia, Khalid, additional

Published
2021
Full Text
View/download PDF

16. Appropriate Shocks and Mortality in Patients With Versus Without Diabetes With Prophylactic Implantable Cardioverter Defibrillators

Author

Junttila, M. Juhani, Pelli, Ari, Kenttä, Tuomas V., Friede, Tim, Willems, Rik, Bergau, Leonard, Malik, Marek, Vandenberk, Bert, Vos, Marc A., Schmidt, Georg, Merkely, Bela, Lubinski, Andrzej, Svetlosak, Martin, Braunschweig, Frieder, Harden, Markus, Zabel, Markus, Huikuri, Heikki V., Sticherling, Christian, Seegers, Joachim, Hasenfuß, Gerd, Munoz-Exposito, Pascal, Tichelbäcker, Tobias, Kirova, Aleksandra, Schlögl, Simon, Sritharan, Rajevaa, Jörß, Katharina, Macken, Jessica, Misdaq, Misbah, Rudolph, Kornelia, Bauer, Axel, Meyer-Zürn, Christine, Eick, Christian, rechts der Isar, Klinikum, Schmidt, Goerg, Müller, Alexander, Dommasch, Michael, Sinnecker, Daniel, Kääb, Stefan, Sinner, Moritz F., Dissmann, Rüdiger, Burmester, Ute, Behrens, Steffen, Gregor, Martina, Stefanow, Stefan, Rüb, Norman, Wolpert, Christian, Bimmel, Dieter, Lieberz, Christiane, Maier, Lars S., Schwinger, Robert H.G., Blaschke, Florian, Pieske, Burkert, Grönefeld, Gerian, Klein, Gunnar, Gardiwal, Ajmal, Szeplaki, Gabor, Perge, Peter, Szavits Nossan, Janko, Rotkvić, Luka, Pavlovic, Nikola, Manola, Sime, Vinter, Ozren, Benko, Ivica, Brusic, Sandro, Avdovic, Ervin, Klasan, Marina, Bakotic, Zoran, Anic, Ante, Jurisic, Zrinka, Kowalczyk, Emilia, Kucejko, Tomasz, Czechowska, Agnieszka, Wybor, Katarina, Cygankiewicz, Iwona, Ptaszyński, Pawel, Kasprzak, Jaroslaw, Qavoq, Dariusz, Guzik, Przemyslaw, Krauze, Tomasz, Sterlinski, Maciej, Hatala, Robert, Kaliska, Gabriela, Martinek, Jozef, Hastrup Svendsen, Jesper, Thamsborg, Karen, Hansen, Jim, Schloett-Hyldelund, Ida-Maria, Laage-Petersen, Julie, van Soest, Sofie, Flevari, Panayota, Katsaras, Dimitrios, Katsimardos, Andreas, Leftheriotis, Dionyssios, Papangelopoulou, Konstantinia, Varlamos, Charalambos, Traykov, Vassil, Velchev, Vasil, Iovev, Svetoslav, Shalganov, Tchavdar, Conen, David, Giesebart, Sarah, Novotny, Tomas, Kozak, Milan, Taborsky, Milos, Galuszka, Jan, Tuinenburg, Anton E., Wijers, Sofieke, Dunnink, Albert, Sprenkeler, David, Brugada, Josep, Arbelo, Elena, Trucco, Emilce, Vidorreta, Silvia, Kenttä, Tuomas, Huikuri, Pirkko, Koski, Päivi, Karlsson, Helena, Ersgaard, David, Platonov, Pyotr, Klingenheben, Thomas, and EU-CERT-ICD Investigators

Subjects
Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Ventricular Function, Left, DISEASE, Sudden cardiac death, Endocrinology, 0302 clinical medicine, Tachycardia, Medicine, FIBROSIS, Advanced and Specialised Nursing, 030212 general & internal medicine, Registries, 11 Medical and Health Sciences, RISK, Electroshock, OUTCOMES, Incidence (epidemiology), Incidence, Hazard ratio, ASSOCIATION, Middle Aged, Implantable cardioverter-defibrillator, 3. Good health, Defibrillators, Implantable, Diabetes and Metabolism, Primary Prevention, PRESERVED EJECTION FRACTION, Cardiology, Female, VENTRICULAR-FIBRILLATION, Life Sciences & Biomedicine, medicine.medical_specialty, 030209 endocrinology & metabolism, Lower risk, Sudden death, 03 medical and health sciences, Endocrinology & Metabolism, Diabetes mellitus, Internal medicine, Journal Article, Internal Medicine, Diabetes Mellitus, Humans, Aged, Retrospective Studies, Advanced and Specialized Nursing, Science & Technology, business.industry, Retrospective cohort study, medicine.disease, Death, Sudden, Cardiac, MYOCARDIAL-INFARCTION, ICD sudden death cardiomyopathy, business, SUDDEN CARDIAC DEATH, Diabetic Angiopathies, Follow-Up Studies
Abstract

OBJECTIVE Diabetes increases the risk of all-cause mortality and sudden cardiac death (SCD). The exact mechanisms leading to sudden death in diabetes are not well known. We compared the incidence of appropriate shocks and mortality in patients with versus without diabetes with a prophylactic implantable cardioverter defibrillator (ICD) included in the retrospective EU-CERT-ICD registry. RESEARCH DESIGN AND METHODS AND RESULTS A total of 3,535 patients from 12 European EU-CERT-ICD centers with a mean age of 63.7 ± 11.2 years (82% males) at the time of ICD implantation were included in the analysis. A total of 995 patients (28%) had a history of diabetes. All patients had an ICD implanted for primary SCD prevention. End points were appropriate shock and all-cause mortality. Mean follow-up time was 3.2 ± 2.3 years. Diabetes was associated with a lower risk of appropriate shocks (adjusted hazard ratio [HR] 0.77 [95% CI 0.62–0.96], P = 0.02). However, patients with diabetes had significantly higher mortality (adjusted HR 1.30 [95% CI 1.11–1.53], P = 0.001). CONCLUSIONS All-cause mortality is higher in patients with diabetes than in patients without diabetes with primary prophylactic ICDs. Subsequently, patients with diabetes have a lower incidence of appropriate ICD shocks, indicating that the excess mortality might not be caused primarily by ventricular tachyarrhythmias. These findings suggest a limitation of the potential of prophylactic ICD therapy to improve survival in patients with diabetes with impaired left ventricular function.

Published
2020

18. Prediction of mortality benefit based on periodic repolarisation dynamics in patients undergoing prophylactic implantation of a defibrillator: a prospective, controlled, multicentre cohort study

Author

Bauer, Axel, primary, Klemm, Mathias, additional, Rizas, Konstantinos D, additional, Hamm, Wolfgang, additional, von Stülpnagel, Lukas, additional, Dommasch, Michael, additional, Steger, Alexander, additional, Lubinski, Andrezej, additional, Flevari, Panagiota, additional, Harden, Markus, additional, Friede, Tim, additional, Kääb, Stefan, additional, Merkely, Bela, additional, Sticherling, Christian, additional, Willems, Rik, additional, Huikuri, Heikki, additional, Malik, Marek, additional, Schmidt, Georg, additional, Zabel, Markus, additional, Merkely, Béla, additional, Perge, Peter, additional, Sallo, Zoltan, additional, Szeplaki, Gabor, additional, Lüthje, Lars, additional, Schlögl, Simon, additional, Haarmann, Helge, additional, Bergau, Leonard, additional, Seegers, Joachim, additional, Hasenfuß, Gerd, additional, Munoz-Exposito, Pascal, additional, Tichelbäcker, Tobias, additional, Kirova, Aleksandra, additional, Hnatkova, Katerina, additional, Vos, Marc, additional, Willich, Stefan N., additional, Reinhold, Thomas, additional, Vandenberk, Bert, additional, Klinika, Magdalena, additional, Toplice, Krapinske, additional, Flevari, Panayota, additional, Katsimardos, Andreas, additional, Katsaras, Dimitrios, additional, Hatala, Robert, additional, Svetlosak, Martin, additional, Lubinski, Andrzej, additional, Kuczejko, Tomasz, additional, Hansen, Jim, additional, Conen, David, additional, Milosrdnice, Sestre, additional, Pavlović, Nikola, additional, Manola, Šime, additional, Vinter, Ozren, additional, Benko, Ivica, additional, Tuinenburg, Anton, additional, Bauer, Axel, additional, Meyer-Zürn, Christine, additional, Eick, Christian, additional, Hastrup, Jesper, additional, Brugada, Josep, additional, Arbelo, Elena, additional, Kaliska, Gabriela, additional, Martinek, Jozef, additional, Sinner, Moritz F., additional, Rizas, Konstantinos D., additional, Vdovin, Nikolay, additional, Cygankiewicz, Iwona, additional, Ptaszynski, Pawel, additional, Kaczmarek, Krzysztof, additional, Poddebska, Izabela, additional, Iovev, Svetoslav, additional, Novotný, Tomáš, additional, Kozak, Milan, additional, Kenttä, Tuomas, additional, Pelli, Ari, additional, Kasprzak, Jaroslaw D., additional, Qavoq, Dariusz, additional, Brusich, Sandro, additional, Avdovic, Ervin, additional, Klasan, Marina, additional, Galuszka, Jan, additional, Taborsky, Milos, additional, Velchev, Vasil, additional, Dissmann, Rüdiger, additional, Guzik, Przemysław, additional, Bimmel, Dieter, additional, Lieberz, Christiane, additional, Stefanow, Stefan, additional, Rüb, Norman, additional, Wolpert, Christian, additional, Maier, Lars S., additional, Behrens, Steffen, additional, Jurisic, Zrinka, additional, Braunschweig, Frieder, additional, Blaschke, Florian, additional, Pieske, Burkert, additional, Bakotic, Zoran, additional, Anic, Ante, additional, Schwinger, Robert H.G., additional, and Platonov, Pyotr, additional

Published
2019
Full Text
View/download PDF

19. Data on differential multivariable risk prediction of appropriate shock vs. competing mortality

Author

Bergau, Leonard, primary, Willems, Rik, additional, Sprenkeler, David J., additional, Fischer, Thomas H., additional, Flevari, Panayota, additional, Hasenfuß, Gerd, additional, Katsaras, Dimitrios, additional, Kirova, Aleksandra, additional, Lehnart, Stephan E., additional, Lüthje, Lars, additional, Röver, Christian, additional, Seegers, Joachim, additional, Sossalla, Samuel, additional, Dunnink, Albert, additional, Sritharan, Rajevaa, additional, Tuinenburg, Anton E., additional, Vandenberk, Bert, additional, Vos, Marc A., additional, Wijers, Sofieke C., additional, Friede, Tim, additional, and Zabel, Markus, additional

Published
2018
Full Text
View/download PDF

20. Sphenopalatine ganglion block: an external gate to modulate cardiac autonomic tone and suppress premature ventricular beats?

Author

Katsaras, Dimitrios N., primary, Arvaniti, Chrysa K., additional, Flevari, Panayota G., additional, Giannopoulos, Georgios V., additional, Batistaki, Chrysanthi Z., additional, Stassinos, Vassilios E., additional, Kostopanagiotou, Georgia G., additional, Deftereos, Spyridon G., additional, Iliodromitis, Efstathios K., additional, and Leftheriotis, Dionyssios I., additional

Published
2018
Full Text
View/download PDF

21. Data on differential multivariable risk prediction of appropriate shock vs. competing mortality

Author

Bergau, Leonard, Willems, Rik, Sprenkeler, David J., Fischer, Thomas H., Flevari, Panayota, Hasenfuß, Gerd, Katsaras, Dimitrios, Kirova, Aleksandra, Lehnart, Stephan E., Lüthje, Lars, Röver, Christian, Seegers, Joachim, Sossalla, Samuel, Dunnink, Albert, Sritharan, Rajevaa, Tuinenburg, Anton E., Vandenberk, Bert, Vos, Marc A., Wijers, Sofieke C., Friede, Tim, Zabel, Markus, Bergau, Leonard, Willems, Rik, Sprenkeler, David J., Fischer, Thomas H., Flevari, Panayota, Hasenfuß, Gerd, Katsaras, Dimitrios, Kirova, Aleksandra, Lehnart, Stephan E., Lüthje, Lars, Röver, Christian, Seegers, Joachim, Sossalla, Samuel, Dunnink, Albert, Sritharan, Rajevaa, Tuinenburg, Anton E., Vandenberk, Bert, Vos, Marc A., Wijers, Sofieke C., Friede, Tim, and Zabel, Markus

Published
2018

22. Data on differential multivariable risk prediction of appropriate shock vs. competing mortality

Author

Medische Fysiologie, UMC Utrecht, Cardiologie, Circulatory Health, Team Medisch, Bergau, Leonard, Willems, Rik, Sprenkeler, David J., Fischer, Thomas H., Flevari, Panayota, Hasenfuß, Gerd, Katsaras, Dimitrios, Kirova, Aleksandra, Lehnart, Stephan E., Lüthje, Lars, Röver, Christian, Seegers, Joachim, Sossalla, Samuel, Dunnink, Albert, Sritharan, Rajevaa, Tuinenburg, Anton E., Vandenberk, Bert, Vos, Marc A., Wijers, Sofieke C., Friede, Tim, Zabel, Markus, Medische Fysiologie, UMC Utrecht, Cardiologie, Circulatory Health, Team Medisch, Bergau, Leonard, Willems, Rik, Sprenkeler, David J., Fischer, Thomas H., Flevari, Panayota, Hasenfuß, Gerd, Katsaras, Dimitrios, Kirova, Aleksandra, Lehnart, Stephan E., Lüthje, Lars, Röver, Christian, Seegers, Joachim, Sossalla, Samuel, Dunnink, Albert, Sritharan, Rajevaa, Tuinenburg, Anton E., Vandenberk, Bert, Vos, Marc A., Wijers, Sofieke C., Friede, Tim, and Zabel, Markus

Published
2018

24. A systematic review and meta-analysis of interventional studies of bisphosphonates and denosumab in multiple myeloma and future perspectives.

Author

Chatziravdeli V, Katsaras GN, Katsaras D, Doxani C, Stefanidis I, and Zintzaras E

Subjects
Humans, Denosumab therapeutic use, Zoledronic Acid, Clodronic Acid therapeutic use, Diphosphonates therapeutic use, Multiple Myeloma drug therapy
Abstract

Bisphosphonates (BPs) and denosumab (DENOS), due to their ability to inhibit osteoclast activity, are used to prevent skeletal complications in multiple myeloma (MM) patients. The NCBI PubMed, Web of Science, Scopus and ClinicalTrials.gov databases, were systematically searched for interventional studies, assessing the use of BP and DENOS in MM patients. Overall survival, disease progression, skeletal-related events, bone pain, osteonecrosis of the jaw (ONJ) and renal toxicity were the outcomes of interest. A total of 993 studies were retrieved and 43 were used for qualitative synthesis. Clodronate (CLOD) and zoledronic acid (ZOL) were effective in reducing skeletal complications compared to placebo. Results are mixed regarding the efficacy of pamidronate in reducing skeletal related events. ONJ rates were higher for ZOL, but under 5%, with CLOD having the safest profile. DENOS demonstrated non-inferiority to ZOL, in improving overall survival [pooled Hazard Ratio(HR) 1.02(95% CI 0.72,1.44)], progression free survival [pooled HR 0.92(95% CI 0.76,1.11)] and in reducing skeletal related events [pooled HR 1.03(95% CI 0.92,1.16)], with similar rates of ONJ and better safety profile regarding renal toxicity. Denosumab has comparable efficacy and safety with ZOL and may even replace BPs in the future, in the management of myeloma bone disease., Competing Interests: The authors have no conflict of interest.

Published
2022

25. Fluoxetine vs. placebo for the treatment of recurrent vasovagal syncope with anxiety sensitivity.

Author

Flevari P, Leftheriotis D, Repasos E, Katsaras D, Katsimardos A, and Lekakis J

Subjects
Adult, Anti-Anxiety Agents adverse effects, Anxiety diagnosis, Anxiety physiopathology, Anxiety psychology, Cardiovascular Agents adverse effects, Female, Fluoxetine adverse effects, Greece, Humans, Male, Personality, Prospective Studies, Recurrence, Selective Serotonin Reuptake Inhibitors adverse effects, Surveys and Questionnaires, Syncope, Vasovagal diagnosis, Syncope, Vasovagal physiopathology, Syncope, Vasovagal psychology, Time Factors, Treatment Outcome, Anti-Anxiety Agents therapeutic use, Anxiety drug therapy, Cardiovascular Agents therapeutic use, Fluoxetine therapeutic use, Selective Serotonin Reuptake Inhibitors therapeutic use, Syncope, Vasovagal drug therapy
Abstract

Aims: The optimal medical therapy of patients with vasovagal syncope (VVS) remains controversial. Fluoxetine is effective against anxiety and panic disorders, while its use has shown promising results for VVS. Anxiety sensitivity is a personality trait observed in a considerable proportion of patients with VVS, associated with predisposition to anxiety and panic disorders. Our aim was to examine whether fluoxetine exerts beneficial effects regarding VVS prevention in the subset of patients with anxiety sensitivity., Methods and Results: We assessed 106 patients with typical history of recurrent VVS, without other comorbidities, and a diagnostic, positive head-up tilt test. A psychiatric examination ruled out clinical psychiatric disease. Their psychological, stress-related profile was assessed by the Anxiety Sensitivity Index (ASI) questionnaire, a 16-item questionnaire, assessing fear of anxiety-related sensations, previously studied in VVS. Patients scoring positive for ASI (n = 60, 57% of the population) were randomized in a 2:1 fashion to receive either 10-40 mg fluoxetine daily (n = 40) or placebo (n = 20), and were followed-up for 1 year. A significant difference was observed between patients receiving fluoxetine and those with placebo, regarding the distribution of syncope-free time during the study (P < 0.05). A significant difference was also observed between the two groups regarding presyncopal events and the total number of patients who experienced syncope or presyncope during follow-up., Conclusion: Sensitivity to anxiety is a common personality trait in recurrent VVS. Fluoxetine is superior to placebo against syncope in these patients. This drug may be a first-line pharmacological treatment for this difficult-to-treat group., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.)

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results