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25. Plasma fibrin clots of pulmonary embolism patients present increased amounts of factor XIII and alpha2-antiplasmin at 3 months' anticoagulation since the acute phase

Author

Ząbczyk, Michał, Natorska, Joanna, Bagoly, Zsuzsa, Sarkady, F., Barath, Barbara, Katona, Eva, Bryk, Agata, Zeitl, K., Wisniewski, Jacek, and Undas, Anetta

Subjects
circulatory and respiratory physiology
Abstract

Fibrin cross-linking by coagulation factor (F)XIII leads to clot stabilization. Reduced plasma FXIII levels have been reported in acute pulmonary embolism (PE) patients. We investigated the impact of anticoagulant therapy on clot-bound amounts of FXIII and alpha 2-antiplasmin and their associations with fibrin clot properties in patients with PE. Clots generated from plasma of 18 acute symptomatic patients on admission and after a 3-month treatment with rivaroxaban were assessed off anticoagulation using mass spectrometry. Plasma FXIII and alpha 2-antiplasmin activity were determined at the 2 time points along with thrombin generation markers, plasma fibrin clot permeability (K-s), and clot lysis time (CLT). Following anticoagulant therapy, clot-bound FXIII increased from 2.97 (interquartile range, 1.98 - 4.08) to 4.66 (3.5 - 6.9) mg/g protein and alpha 2-antiplasmin from 9.4 (7.2 - 10.6) to 11 (9.5 - 14) mg/g protein (both p < 0.0001). The two parameters showed positive correlation at baseline only (r = 0.63, p = 0.0056). Similarly to clot-bound amounts, plasma FXIII (+25.8%) and alpha 2-antiplasmin activity (+12%) increased at 3 months. Plasma FXIII activity on admission, but not after 3 months since the index PE, was associated with amounts of clot-bound FXIII (r = 0.35, p = 0.043) and alpha 2-antiplasmin (r = 0.47, p = 0.048). At baseline, clot-bound FXIII correlated with plasma F1+2 prothrombin fragments levels (r = 0.51, p = 0.03), while clot-bound alpha 2-antiplasmin correlated with CLT (r = 0.43, p = 0.036). At 3 months associations of clot-bound FXIII and alpha 2-antiplasmin were abolished. This study assessed for the first time changes in the fibrin clot composition following acute PE, suggesting an increase of clot-bound and plasma FXIII and alpha 2-antiplasmin levels after 3 months.

Published
2020

28. Relationship between photosynthetic electron transport and pH gradient across the thylakoid membrane in intact leaves

Author

Schonknecht, Gerald, Neimanis, Spidola, Katona, Eva, Gerst, Ulvi, and Heber, Ulrich

Subjects
Leaves -- Physiological aspects, Photosynthesis -- Regulation, Electron transport -- Research, Spinach -- Physiological aspects, Science and technology
Abstract

A study was conducted to test the hypothesis that the light-dependent pH gradient regulates electron transport during photosynthesis in plants. Thylakoid membranes from intact leaves of spinach were isolated and the ATP hydrolysis activity was measured. The stoichiometry of the reaction was measured by calculating carbon dioxide uptake rate. The equation for calculating light-dependent pH gradient is provided.

Published
1995

35. Dietary self-efficacy: determinant of compliance behaviours and biochemical outcomes in haemodialysis patients

Author

Zrinyi, Miklos, Juhasz, Maria, Balla, Jozsef, Katona, Eva, Ben, Thomas, Kakuk, Gyorgy, Pall, Denes, Zrinyi, Miklos, Juhasz, Maria, Balla, Jozsef, Katona, Eva, Ben, Thomas, Kakuk, Gyorgy, and Pall, Denes

Abstract

Background. Despite the diversity of proposed theories, researchers are still unable to fully explain dietary compliance behaviours of dialysis patients. Dietary self-efficacy, a concept less studied in dialysis, has been linked to positive compliance outcomes in the chronic illness literature. Therefore, the aim of the present research was to determine how dietary self-efficacy is related to selected biochemical markers and self-reported behavioural outcomes in haemodialysis patients. Methods. 107 subjects participated in a cross-sectional study. Four questionnaires assessed dietary self-efficacy, compliance attitudes and behaviours, and staff-patient relationships. Laboratory outcomes were retrospectively obtained from patients' medical records and averaged for the previous 6 months. Results. Of the behavioural measures, only dietary self-efficacy was associated with laboratory outcomes. Dietary self-efficacy was also positively related to staff-patient relationships and to patients' self-reported assessment of compliance behaviours. Women had greater dietary self-efficacy than men. The number of family members living with the respondent was inversely related to dietary self-efficacy. Conclusions. Results indicated that dietary self-efficacy determined both behaviours and laboratory outcomes. Patients with greater dietary self-efficacy had lower serum potassium and weight gain, showed favourable compliance attitudes and behaviours toward prescribed regimens and fostered better relationships with staff. Based on these findings we recommend an experimental approach to clarify whether maximizing dietary self-efficacy efforts is without psychological burden to patients and whether the positive effect of increased dietary self-efficacy is maintained in long-term dialysis patients

Published
2017

38. Modification of tooth development by heat shock protein 60

Author

Papp, Tamas, primary, Polyak, Angela, additional, Papp, Krisztina, additional, Meszar, Zoltan, additional, Zakany, Roza, additional, Meszar-Katona, Eva, additional, Tünde, Palne Terdik, additional, Ham, Chang Hwa, additional, and Felszeghy, Szabolcs, additional

Published
2016
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43. Epigallocatechin 3-O-gallate Induces 67 kDa Laminin Receptor-Mediated Cell Death Accompanied by Downregulation of ErbB Proteins and Altered Lipid Raft Clustering in Mammary and Epidermoid Carcinoma Cells

Author

Mocanu, Maria-Magdalena, primary, Ganea, Constanţa, additional, Georgescu, Laura, additional, Váradi, Tímea, additional, Shrestha, Dilip, additional, Baran, Irina, additional, Katona, Eva, additional, Nagy, Peter, additional, and Szöllősi, János, additional

Published
2014
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